                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  DISCOVERY OF ENZYMES FROM THE ALPHA-KETO ACID DECARBOXYLASE 
       FAMILY

<130>  081906-219110PC-1021502

<140>  PCT/US16/049210
<141>  2016-08-29

<150>  US 62/211,439
<151>  2015-08-28

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  1

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  2
<211>  536
<212>  PRT
<213>  Streptomyces sp. C

<400>  2

Met Arg Thr Val Arg Glu Ser Ala Leu Asp Val Leu Arg Ala Arg Gly 
1               5                   10                  15      


Met Thr Thr Val Phe Gly Asn Pro Gly Ser Thr Glu Leu Pro Met Leu 
            20                  25                  30          


Lys Gln Phe Pro Asp Asp Phe Arg Tyr Val Leu Gly Leu Gln Glu Ala 
        35                  40                  45              


Val Val Val Gly Met Ala Asp Gly Phe Ala Leu Ala Ser Gly Thr Thr 
    50                  55                  60                  


Gly Leu Val Asn Leu His Thr Gly Pro Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  


Ala Ile Leu Asn Ala Arg Ala Asn Arg Thr Pro Met Val Val Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Ala Met Leu Thr Met Glu Ala Leu Leu Thr Asn 
            100                 105                 110         


Pro Gln Ser Thr Leu Leu Pro Gln Pro Ala Val Lys Trp Ala Tyr Glu 
        115                 120                 125             


Pro Pro Arg Ala Ala Asp Val Ala Pro Ala Leu Ala Arg Ala Val Gln 
    130                 135                 140                 


Val Ala Glu Thr Pro Pro Gln Gly Pro Val Phe Val Ser Leu Pro Met 
145                 150                 155                 160 


Asp Asp Phe Asp Val Val Leu Gly Glu Asp Glu Asp Arg Ala Ala Gln 
                165                 170                 175     


Arg Ala Ala Ala Arg Thr Val Thr His Ala Ala Ala Pro Ser Ala Glu 
            180                 185                 190         


Val Val Arg Arg Leu Ala Ala Arg Leu Ser Gly Ala Arg Ser Ala Val 
        195                 200                 205             


Leu Val Ala Gly Asn Asp Val Asp Ala Ser Gly Ala Trp Asp Ala Val 
    210                 215                 220                 


Val Glu Leu Ala Glu Arg Thr Gly Leu Pro Val Trp Ser Ala Pro Thr 
225                 230                 235                 240 


Glu Gly Arg Val Ala Phe Pro Lys Ser His Pro Gln Tyr Arg Gly Met 
                245                 250                 255     


Leu Pro Pro Ala Ile Ala Pro Leu Ser Arg Cys Leu Glu Gly His Asp 
            260                 265                 270         


Leu Val Leu Val Ile Gly Ala Pro Val Phe Cys Tyr Tyr Pro Tyr Val 
        275                 280                 285             


Pro Gly Ala His Leu Pro Glu Asn Thr Glu Leu Val His Leu Thr Arg 
    290                 295                 300                 


Asp Ala Asp Glu Ala Ala Arg Ala Pro Val Gly Asp Ala Val Val Ala 
305                 310                 315                 320 


Asp Leu Ala Leu Thr Val Arg Ala Leu Leu Ala Glu Leu Pro Ala Arg 
                325                 330                 335     


Glu Ala Ala Ala Pro Ala Ala Arg Thr Ala Arg Ala Glu Ser Thr Ala 
            340                 345                 350         


Glu Val Asp Gly Val Leu Thr Pro Leu Ala Ala Met Thr Ala Ile Ala 
        355                 360                 365             


Gln Gly Ala Pro Ala Asn Thr Leu Trp Val Asn Glu Ser Pro Ser Asn 
    370                 375                 380                 


Leu Gly Gln Phe His Asp Ala Thr Arg Ile Asp Thr Pro Gly Ser Phe 
385                 390                 395                 400 


Leu Phe Thr Ala Gly Gly Gly Leu Gly Phe Gly Leu Ala Ala Ala Val 
                405                 410                 415     


Gly Ala Gln Leu Gly Ala Pro Asp Arg Pro Val Val Cys Val Ile Gly 
            420                 425                 430         


Asp Gly Ser Thr His Tyr Ala Val Gln Ala Leu Trp Thr Ala Ala Ala 
        435                 440                 445             


Tyr Lys Val Pro Val Thr Phe Val Val Leu Ser Asn Gln Arg Tyr Ala 
    450                 455                 460                 


Ile Leu Gln Trp Phe Ala Gln Val Glu Gly Ala Gln Gly Ala Pro Gly 
465                 470                 475                 480 


Leu Asp Ile Pro Gly Leu Asp Ile Ala Ala Val Ala Thr Gly Tyr Gly 
                485                 490                 495     


Val Arg Ala His Arg Ala Thr Gly Phe Gly Glu Leu Ser Lys Leu Val 
            500                 505                 510         


Arg Glu Ser Ala Leu Gln Gln Asp Gly Pro Val Leu Ile Asp Val Pro 
        515                 520                 525             


Val Thr Thr Glu Leu Pro Thr Leu 
    530                 535     


<210>  3
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein KIVD_VLV

<400>  3

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Val Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Leu Gly Lys Leu Val Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  4
<211>  570
<212>  PRT
<213>  Schizosaccaromyces pombe

<400>  4

Met Ser Ser Glu Lys Val Leu Val Gly Glu Tyr Leu Phe Thr Arg Leu 
1               5                   10                  15      


Leu Gln Leu Gly Ile Lys Ser Ile Leu Gly Val Pro Gly Asp Phe Asn 
            20                  25                  30          


Leu Ala Leu Leu Asp Leu Ile Glu Lys Val Gly Asp Glu Thr Phe Arg 
        35                  40                  45              


Trp Val Gly Asn Glu Asn Glu Leu Asn Gly Ala Tyr Ala Ala Asp Ala 
    50                  55                  60                  


Tyr Ala Arg Val Lys Gly Ile Ser Ala Ile Val Thr Thr Phe Gly Val 
65                  70                  75                  80  


Gly Glu Leu Ser Ala Leu Asn Gly Phe Ala Gly Ala Tyr Ser Glu Arg 
                85                  90                  95      


Ile Pro Val Val His Ile Val Gly Val Pro Asn Thr Lys Ala Gln Ala 
            100                 105                 110         


Thr Arg Pro Leu Leu His His Thr Leu Gly Asn Gly Asp Phe Lys Val 
        115                 120                 125             


Phe Gln Arg Met Ser Ser Glu Leu Ser Ala Asp Val Ala Phe Leu Asp 
    130                 135                 140                 


Ser Gly Asp Ser Ala Gly Arg Leu Ile Asp Asn Leu Leu Glu Thr Cys 
145                 150                 155                 160 


Val Arg Thr Ser Arg Pro Val Tyr Leu Ala Val Pro Ser Asp Ala Gly 
                165                 170                 175     


Tyr Phe Tyr Thr Asp Ala Ser Pro Leu Lys Thr Pro Leu Val Phe Pro 
            180                 185                 190         


Val Pro Glu Asn Asn Lys Glu Ile Glu His Glu Val Val Ser Glu Ile 
        195                 200                 205             


Leu Glu Leu Ile Glu Lys Ser Lys Asn Pro Ser Ile Leu Val Asp Ala 
    210                 215                 220                 


Cys Val Ser Arg Phe His Ile Gln Gln Glu Thr Gln Asp Phe Ile Asp 
225                 230                 235                 240 


Ala Thr His Phe Pro Thr Tyr Val Thr Pro Met Gly Lys Thr Ala Ile 
                245                 250                 255     


Asn Glu Ser Ser Pro Tyr Phe Asp Gly Val Tyr Ile Gly Ser Leu Thr 
            260                 265                 270         


Glu Pro Ser Ile Lys Glu Arg Ala Glu Ser Thr Asp Leu Leu Leu Ile 
        275                 280                 285             


Ile Gly Gly Leu Arg Ser Asp Phe Asn Ser Gly Thr Phe Thr Tyr Ala 
    290                 295                 300                 


Thr Pro Ala Ser Gln Thr Ile Glu Phe His Ser Asp Tyr Thr Lys Ile 
305                 310                 315                 320 


Arg Ser Gly Val Tyr Glu Gly Ile Ser Met Lys His Leu Leu Pro Lys 
                325                 330                 335     


Leu Thr Ala Ala Ile Asp Lys Lys Ser Val Gln Ala Lys Ala Arg Pro 
            340                 345                 350         


Val His Phe Glu Pro Pro Lys Ala Val Ala Ala Glu Gly Tyr Ala Glu 
        355                 360                 365             


Gly Thr Ile Thr His Lys Trp Phe Trp Pro Thr Phe Ala Ser Phe Leu 
    370                 375                 380                 


Arg Glu Ser Asp Val Val Thr Thr Glu Thr Gly Thr Ser Asn Phe Gly 
385                 390                 395                 400 


Ile Leu Asp Cys Ile Phe Pro Lys Gly Cys Gln Asn Leu Ser Gln Val 
                405                 410                 415     


Leu Trp Gly Ser Ile Gly Trp Ser Val Gly Ala Met Phe Gly Ala Thr 
            420                 425                 430         


Leu Gly Ile Lys Asp Ser Asp Ala Pro His Arg Arg Ser Ile Leu Ile 
        435                 440                 445             


Val Gly Asp Gly Ser Leu His Leu Thr Val Gln Glu Ile Ser Ala Thr 
    450                 455                 460                 


Ile Arg Asn Gly Leu Thr Pro Ile Ile Phe Val Ile Asn Asn Lys Gly 
465                 470                 475                 480 


Tyr Thr Ile Glu Arg Leu Ile His Gly Leu His Ala Val Tyr Asn Asp 
                485                 490                 495     


Ile Asn Thr Glu Trp Asp Tyr Gln Asn Leu Leu Lys Gly Tyr Gly Ala 
            500                 505                 510         


Lys Asn Ser Arg Ser Tyr Asn Ile His Ser Glu Lys Glu Leu Leu Asp 
        515                 520                 525             


Leu Phe Lys Asp Glu Glu Phe Gly Lys Ala Asp Val Ile Gln Leu Val 
    530                 535                 540                 


Glu Val His Met Pro Val Leu Asp Ala Pro Arg Val Leu Ile Glu Gln 
545                 550                 555                 560 


Ala Lys Leu Thr Ala Ser Leu Asn Lys Gln 
                565                 570 


<210>  5
<211>  574
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  5

Met Glu Leu Leu Ser Gly Gly Glu Met Leu Val Arg Ala Leu Ala Asp 
1               5                   10                  15      


Glu Gly Val Glu His Val Phe Gly Tyr Pro Gly Gly Ala Val Leu His 
            20                  25                  30          


Ile Tyr Asp Ala Leu Phe Gln Gln Asp Lys Ile Asn His Tyr Leu Val 
        35                  40                  45              


Arg His Glu Gln Ala Ala Gly His Met Ala Asp Ala Tyr Ser Arg Ala 
    50                  55                  60                  


Thr Gly Lys Thr Gly Val Val Leu Val Thr Ser Gly Pro Gly Ala Thr 
65                  70                  75                  80  


Asn Thr Val Thr Pro Ile Ala Thr Ala Tyr Met Asp Ser Ile Pro Met 
                85                  90                  95      


Val Ile Leu Ser Gly Gln Val Ala Ser His Leu Ile Gly Glu Asp Ala 
            100                 105                 110         


Phe Gln Glu Thr Asp Met Val Gly Ile Ser Arg Pro Ile Val Lys His 
        115                 120                 125             


Ser Phe Gln Val Arg His Ala Ser Glu Ile Pro Ala Ile Ile Lys Lys 
    130                 135                 140                 


Ala Phe Tyr Ile Ala Ala Ser Gly Arg Pro Gly Pro Val Val Val Asp 
145                 150                 155                 160 


Ile Pro Lys Asp Ala Thr Asn Pro Ala Glu Lys Phe Ala Tyr Glu Tyr 
                165                 170                 175     


Pro Glu Lys Val Lys Met Arg Ser Tyr Gln Pro Pro Ser Arg Gly His 
            180                 185                 190         


Ser Gly Gln Ile Arg Lys Ala Ile Asp Glu Leu Leu Ser Ala Lys Arg 
        195                 200                 205             


Pro Val Ile Tyr Thr Gly Gly Gly Val Val Gln Gly Asn Ala Ser Ala 
    210                 215                 220                 


Leu Leu Thr Glu Leu Ala His Leu Leu Gly Tyr Pro Val Thr Asn Thr 
225                 230                 235                 240 


Leu Met Gly Leu Gly Gly Phe Pro Gly Asp Asp Pro Gln Phe Val Gly 
                245                 250                 255     


Met Leu Gly Met His Gly Thr Tyr Glu Ala Asn Met Ala Met His Asn 
            260                 265                 270         


Ala Asp Val Ile Leu Ala Ile Gly Ala Arg Phe Asp Asp Arg Val Thr 
        275                 280                 285             


Asn Asn Pro Ala Lys Phe Cys Val Asn Ala Lys Val Ile His Ile Asp 
    290                 295                 300                 


Ile Asp Pro Ala Ser Ile Ser Lys Thr Ile Met Ala His Ile Pro Ile 
305                 310                 315                 320 


Val Gly Ala Val Glu Pro Val Leu Gln Glu Met Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Leu Asn Val Ser Lys Pro Asn Pro Glu Ala Ile Ala Ala Trp Trp 
            340                 345                 350         


Asp Gln Ile Asn Glu Trp Arg Lys Val His Gly Leu Lys Phe Glu Thr 
        355                 360                 365             


Pro Thr Asp Gly Thr Met Lys Pro Gln Gln Val Val Glu Ala Leu Tyr 
    370                 375                 380                 


Lys Ala Thr Asn Gly Asp Ala Ile Ile Thr Ser Asp Val Gly Gln His 
385                 390                 395                 400 


Gln Met Phe Gly Ala Leu Tyr Tyr Lys Tyr Lys Arg Pro Arg Gln Trp 
                405                 410                 415     


Ile Asn Ser Gly Gly Leu Gly Thr Met Gly Val Gly Leu Pro Tyr Ala 
            420                 425                 430         


Met Ala Ala Lys Leu Ala Phe Pro Asp Gln Gln Val Val Cys Ile Thr 
        435                 440                 445             


Gly Glu Ala Ser Ile Gln Met Cys Ile Gln Glu Leu Ser Thr Cys Lys 
    450                 455                 460                 


Gln Tyr Gly Met Asn Val Lys Ile Leu Cys Leu Asn Asn Arg Ala Leu 
465                 470                 475                 480 


Gly Met Val Lys Gln Trp Gln Asp Met Asn Tyr Glu Gly Arg His Ser 
                485                 490                 495     


Ser Ser Tyr Val Glu Ser Leu Pro Asp Phe Gly Lys Leu Met Glu Ala 
            500                 505                 510         


Tyr Gly His Val Gly Ile Gln Ile Asp His Ala Asp Glu Leu Glu Ser 
        515                 520                 525             


Lys Leu Ala Glu Ala Met Ala Ile Asn Asp Lys Cys Val Phe Ile Asn 
    530                 535                 540                 


Val Met Val Asp Arg Thr Glu His Val Tyr Pro Met Leu Ile Ala Gly 
545                 550                 555                 560 


Gln Ser Met Lys Asp Met Trp Leu Gly Lys Gly Glu Arg Thr 
                565                 570                 


<210>  6
<211>  538
<212>  PRT
<213>  Comamonas testosteroni

<400>  6

Met Pro Ala Asn Thr Ala Pro Asn Ala Gln Ala Ala Glu Val Phe Thr 
1               5                   10                  15      


Val Arg His Ala Val Ile Asn Met Leu Arg Glu Leu Gly Met Thr Arg 
            20                  25                  30          


Ile Phe Gly Asn Pro Gly Ser Thr Glu Leu Pro Leu Phe Arg Asp Tyr 
        35                  40                  45              


Pro Glu Asp Phe Ser Tyr Ile Leu Gly Leu Gln Glu Thr Val Val Val 
    50                  55                  60                  


Gly Met Ala Asp Gly Tyr Ala Gln Ala Thr Arg Asn Ala Ser Phe Val 
65                  70                  75                  80  


Asn Leu His Ser Ala Ala Gly Val Gly His Ala Met Ala Asn Ile Phe 
                85                  90                  95      


Thr Ala Phe Lys Asn Arg Thr Pro Met Val Ile Thr Ala Gly Gln Gln 
            100                 105                 110         


Thr Arg Ser Leu Leu Gln Phe Asp Pro Phe Leu His Ser Asn Gln Ala 
        115                 120                 125             


Ala Glu Leu Pro Lys Pro Tyr Val Lys Trp Ser Cys Glu Pro Ala Arg 
    130                 135                 140                 


Ala Glu Asp Val Pro Gln Ala Leu Ala Arg Ala Tyr Tyr Ile Ala Met 
145                 150                 155                 160 


Gln Glu Pro Arg Gly Pro Val Phe Val Ser Ile Pro Ala Asp Asp Trp 
                165                 170                 175     


Asp Val Pro Cys Glu Pro Ile Thr Leu Arg Lys Val Gly Phe Glu Thr 
            180                 185                 190         


Arg Pro Asp Pro Arg Leu Leu Asp Ser Ile Gly Gln Ala Leu Glu Gly 
        195                 200                 205             


Ala Arg Ala Pro Ala Phe Val Val Gly Ala Ala Val Asp Arg Ser Gln 
    210                 215                 220                 


Ala Phe Glu Ala Val Gln Ala Leu Ala Glu Arg His Gln Ala Arg Val 
225                 230                 235                 240 


Tyr Val Ala Pro Met Ser Gly Arg Cys Gly Phe Pro Glu Asp His Ala 
                245                 250                 255     


Leu Phe Gly Gly Phe Leu Pro Ala Met Arg Glu Arg Ile Val Asp Arg 
            260                 265                 270         


Leu Ser Gly His Asp Val Val Phe Val Ile Gly Ala Pro Ala Phe Thr 
        275                 280                 285             


Tyr His Val Glu Gly His Gly Pro Phe Ile Ala Glu Gly Thr Gln Leu 
    290                 295                 300                 


Phe Gln Leu Ile Glu Asp Pro Ala Ile Ala Ala Trp Ala Pro Val Gly 
305                 310                 315                 320 


Asp Ala Ala Val Gly Asn Ile Arg Met Gly Val Gln Glu Leu Leu Ala 
                325                 330                 335     


Arg Pro Leu Thr His Pro Arg Pro Ala Leu Gln Pro Arg Pro Ala Ile 
            340                 345                 350         


Pro Ala Pro Ala Ala Pro Glu Pro Gly Arg Leu Met Thr Asp Ala Phe 
        355                 360                 365             


Leu Met His Thr Leu Ala Gln Val Arg Ser Arg Asp Ser Ile Ile Val 
    370                 375                 380                 


Glu Glu Ala Pro Gly Ser Arg Ser Ile Ile Gln Ala His Leu Pro Ile 
385                 390                 395                 400 


Tyr Ala Ala Glu Thr Phe Phe Thr Met Cys Ser Gly Gly Leu Gly His 
                405                 410                 415     


Ser Leu Pro Ala Ser Val Gly Ile Ala Leu Ala Arg Pro Asp Lys Lys 
            420                 425                 430         


Val Ile Gly Val Ile Gly Asp Gly Ser Ala Met Tyr Ala Ile Gln Ala 
        435                 440                 445             


Leu Trp Ser Ala Ala His Leu Lys Leu Pro Val Thr Tyr Ile Ile Val 
    450                 455                 460                 


Lys Asn Arg Arg Tyr Ala Ala Leu Gln Asp Phe Ser Arg Val Phe Gly 
465                 470                 475                 480 


Tyr Arg Glu Gly Glu Lys Val Glu Gly Thr Asp Leu Pro Asp Ile Asp 
                485                 490                 495     


Phe Val Ala Leu Ala Lys Gly Gln Gly Cys Asp Gly Val Arg Val Thr 
            500                 505                 510         


Asp Ala Ala Gln Leu Ser Gln Val Leu Arg Asp Ala Leu Arg Ser Pro 
        515                 520                 525             


Arg Ala Thr Leu Val Glu Val Glu Val Ala 
    530                 535             


<210>  7
<211>  548
<212>  PRT
<213>  Enterococcus moraviensis

<400>  7

Met Tyr Thr Val Ala Asp Tyr Leu Leu Asp Arg Leu Lys Glu Leu Gly 
1               5                   10                  15      


Ile Asp Glu Val Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp His Ile Thr Ala Arg Lys Asp Leu Glu Trp Ile Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ala Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Gly 
    50                  55                  60                  


Ile Ser Ala Leu Val Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Ser Ile Pro Val Ile Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Thr Thr Val Gln Gln Asn Lys Lys Leu Val His 
            100                 105                 110         


His Thr Leu Gly Asp Gly Asp Phe Leu Arg Phe Glu Arg Ile His Glu 
        115                 120                 125             


Glu Val Ser Ala Ala Ile Ala His Leu Ser Thr Glu Asn Ala Pro Ser 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Thr Val Ala Met Thr Glu Lys Arg Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Ile Asp Ile Ala Glu Met Lys Ala Ser Ala Pro 
                165                 170                 175     


Thr Thr Pro Leu Asn His Thr Thr Asp Gln Leu Thr Thr Val Glu Thr 
            180                 185                 190         


Ala Ile Leu Thr Lys Val Glu Asp Ala Leu Lys Gln Ser Lys Asn Pro 
        195                 200                 205             


Val Val Ile Ala Gly His Glu Ile Leu Ser Tyr His Ile Glu Asn Gln 
    210                 215                 220                 


Leu Glu Gln Phe Ile Gln Lys Phe Asn Leu Pro Ile Thr Val Leu Pro 
225                 230                 235                 240 


Phe Gly Lys Gly Ala Phe Asn Glu Glu Asp Ala His Tyr Leu Gly Thr 
                245                 250                 255     


Tyr Thr Gly Ser Thr Thr Asp Glu Ser Met Lys Asn Arg Val Asp His 
            260                 265                 270         


Ala Asp Leu Val Leu Leu Leu Gly Ala Lys Leu Thr Asp Ser Ala Thr 
        275                 280                 285             


Ser Gly Phe Ser Phe Gly Phe Thr Glu Lys Gln Met Ile Ser Ile Gly 
    290                 295                 300                 


Ser Thr Glu Val Leu Phe Tyr Gly Glu Lys Gln Glu Thr Val Gln Leu 
305                 310                 315                 320 


Asp Arg Phe Val Ser Ala Leu Ser Thr Leu Ser Phe Ser Arg Phe Thr 
                325                 330                 335     


Asp Glu Met Pro Ser Val Lys Arg Leu Ala Thr Pro Lys Val Arg Asp 
            340                 345                 350         


Glu Lys Leu Thr Gln Lys Gln Phe Trp Gln Met Val Glu Ser Phe Leu 
        355                 360                 365             


Leu Gln Gly Asp Thr Val Val Gly Glu Gln Gly Thr Ser Phe Phe Gly 
    370                 375                 380                 


Leu Thr Asn Val Pro Leu Lys Lys Asp Met His Phe Ile Gly Gln Pro 
385                 390                 395                 400 


Leu Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ser Ala Leu Gly Ser Gln 
                405                 410                 415     


Ile Ala Asn Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser 
            420                 425                 430         


Leu Gln Leu Thr Val Gln Glu Leu Gly Thr Ala Ile Arg Glu Lys Leu 
        435                 440                 445             


Thr Pro Ile Val Phe Val Ile Asn Asn Asn Gly Tyr Thr Val Glu Arg 
    450                 455                 460                 


Glu Ile His Gly Ala Thr Glu Gln Tyr Asn Asp Ile Pro Met Trp Asp 
465                 470                 475                 480 


Tyr Gln Lys Leu Pro Phe Val Phe Gly Gly Thr Asp Gln Thr Val Ala 
                485                 490                 495     


Thr Tyr Lys Val Ser Thr Glu Ile Glu Leu Asp Asn Ala Met Thr Arg 
            500                 505                 510         


Ala Arg Thr Asp Val Asp Arg Leu Gln Trp Ile Glu Val Val Met Asp 
        515                 520                 525             


Gln Asn Asp Ala Pro Val Leu Leu Lys Lys Leu Ala Lys Ile Phe Ala 
    530                 535                 540                 


Lys Gln Asn Ser 
545             


<210>  8
<211>  559
<212>  PRT
<213>  Streptomyces sp. HmicA12

<400>  8

Met Val Ser Arg Pro Ala Arg Val Ala Ile Leu Glu Gln Leu Arg Ala 
1               5                   10                  15      


Asp Gly Val Arg Tyr Met Phe Gly Asn Pro Gly Thr Val Glu Gln Gly 
            20                  25                  30          


Phe Leu Asp Glu Leu Arg Asn Phe Pro Asp Ile Glu Tyr Ile Leu Ala 
        35                  40                  45              


Leu Gln Glu Ala Gly Val Val Gly Leu Ala Asp Gly Tyr Ala Arg Ala 
    50                  55                  60                  


Thr Arg Thr Pro Ala Val Leu Gln Leu His Thr Gly Val Gly Val Gly 
65                  70                  75                  80  


Asn Ala Val Gly Met Leu Tyr Gln Ala Lys Arg Gly His Ala Pro Leu 
                85                  90                  95      


Val Ala Ile Ala Gly Glu Ala Gly Leu Arg Tyr Asp Ala Met Glu Ala 
            100                 105                 110         


Gln Met Ala Val Asp Leu Val Ala Met Ala Glu Pro Val Thr Lys Trp 
        115                 120                 125             


Ala Thr Arg Val Val Asp Pro Glu Ser Thr Leu Arg Val Leu Arg Arg 
    130                 135                 140                 


Ala Met Lys Val Ala Ala Thr Pro Pro Tyr Gly Pro Val Leu Val Val 
145                 150                 155                 160 


Leu Pro Ala Asp Val Met Asp Arg Asp Thr Ser Glu Ala Ala Val Pro 
                165                 170                 175     


Thr Ser Tyr Val Asp Phe Ala Ala Thr Pro Asp Pro Gln Val Leu Asp 
            180                 185                 190         


Arg Ala Ala Glu Leu Leu Ala Gly Ala Glu Arg Pro Ile Val Ile Ala 
        195                 200                 205             


Gly Asp Gly Val His Phe Ala Gly Ala Gln Glu Glu Leu Gly Arg Leu 
    210                 215                 220                 


Ala Gln Thr Trp Gly Ala Glu Val Trp Gly Ala Asp Trp Ala Glu Val 
225                 230                 235                 240 


Asn Leu Ser Val Glu His Pro Ala Tyr Ala Gly Gln Leu Gly His Met 
                245                 250                 255     


Phe Gly Asp Ser Ser Arg Arg Val Thr Gly Ala Ala Asp Ala Val Leu 
            260                 265                 270         


Leu Val Gly Thr Tyr Ala Leu Pro Glu Val Tyr Pro Ala Leu Asp Gly 
        275                 280                 285             


Val Phe Ala Asp Gly Ala Pro Val Val His Ile Asp Leu Asp Thr Asp 
    290                 295                 300                 


Ala Ile Ala Lys Asn Phe Pro Val Asp Leu Gly Leu Ala Ala Asp Pro 
305                 310                 315                 320 


Arg Arg Ala Leu Asp Gly Leu Ala Arg Ala Leu Glu Arg Arg Met Ser 
                325                 330                 335     


Pro Glu Ser Arg Ala Arg Ala Gly Glu Trp Phe Thr Gly Arg Ser Ala 
            340                 345                 350         


Gln Arg Ser Tyr Glu Ile Ala Ala Ala Arg Glu Gln Asp Glu Ala Ala 
        355                 360                 365             


Leu Ala Pro Asp Ala Leu Pro Val Thr Ala Phe Leu Gln Glu Leu Ala 
    370                 375                 380                 


Arg Gln Leu Pro Glu Asp Ala Val Val Phe Asp Glu Ala Leu Thr Ala 
385                 390                 395                 400 


Ser Pro Asp Val Thr Arg His Leu Pro Pro Thr Arg Pro Gly His Trp 
                405                 410                 415     


His Gln Thr Arg Gly Gly Ser Leu Gly Val Gly Ile Pro Gly Ala Ile 
            420                 425                 430         


Ala Ala Gln Leu Ala His Pro Asp Arg Thr Val Val Gly Phe Thr Gly 
        435                 440                 445             


Asp Gly Gly Ser Leu Tyr Thr Ile Gln Ala Leu Trp Thr Ala Ala Arg 
    450                 455                 460                 


Tyr Asp Ile Gly Ala Thr Phe Val Ile Cys Asn Asn Ser Ser Tyr Lys 
465                 470                 475                 480 


Leu Leu Glu Leu Asn Ile Glu Glu Tyr Trp Lys Ser Val Asp Val Ala 
                485                 490                 495     


Ala His Glu Gln Pro Glu Met Phe Asp Leu Ala Arg Pro Ala Ile Asp 
            500                 505                 510         


Phe Val Ala Leu Ser Arg Ser Leu Gly Val Pro Ala Val Arg Val Glu 
        515                 520                 525             


Lys Pro Asp Gln Ala Lys Ala Ala Val Glu Gln Ala Leu Gly Thr Pro 
    530                 535                 540                 


Gly Pro Phe Leu Ile Asp Leu Val Thr Gly Arg Gly Arg Glu Asp 
545                 550                 555                 


<210>  9
<211>  536
<212>  PRT
<213>  Amycolatopsis alba

<400>  9

Met Asn Val Ala Glu Leu Val Gly Arg Thr Leu Ala Glu Leu Gly Val 
1               5                   10                  15      


Gly Ala Ala Phe Gly Val Val Gly Ser Gly Asn Phe Val Val Thr Asn 
            20                  25                  30          


Gly Leu Arg Ala Gly Gly Val Arg Phe Val Ala Ala Arg His Glu Gly 
        35                  40                  45              


Gly Ala Ala Ser Met Ala Asp Ala Tyr Ala Arg Met Ser Gly Arg Val 
    50                  55                  60                  


Ser Val Leu Ser Leu His Gln Gly Cys Gly Leu Thr Asn Ala Leu Thr 
65                  70                  75                  80  


Gly Ile Thr Glu Ala Ala Lys Ser Arg Thr Pro Met Ile Val Leu Thr 
                85                  90                  95      


Gly Asp Thr Ala Ala Ser Ala Val Leu Ser Asn Phe Arg Ile Gly Gln 
            100                 105                 110         


Asp Ala Leu Ala Thr Ala Val Gly Ala Val Pro Glu Arg Val His Ser 
        115                 120                 125             


Ala Pro Thr Ala Val Ala Asp Thr Val Arg Ala Tyr Arg Thr Ala Val 
    130                 135                 140                 


Gln Gln Arg Arg Thr Val Leu Leu Asn Leu Pro Leu Asp Val Gln Ala 
145                 150                 155                 160 


Gln Glu Ala Pro Glu Ala Val Glu Ile Pro Lys Val Arg Gly Pro Ala 
                165                 170                 175     


Pro Ile Arg Pro Asp Ala Gly Met Val Ala Lys Leu Ala Asp Leu Leu 
            180                 185                 190         


Ala Glu Ala Arg Arg Pro Val Phe Ile Ala Gly Arg Gly Ala Arg Ala 
        195                 200                 205             


Ser Ala Val Pro Leu Arg Glu Leu Ala Glu Ile Ser Gly Ala Leu Leu 
    210                 215                 220                 


Ala Thr Ser Ala Val Ala His Gly Leu Phe His Asp Asp Pro Phe Ser 
225                 230                 235                 240 


Leu Gly Ile Ser Gly Gly Phe Ser Ser Pro Arg Thr Ala Asp Leu Ile 
                245                 250                 255     


Val Asp Ala Asp Leu Val Ile Gly Trp Gly Cys Ala Leu Asn Met Trp 
            260                 265                 270         


Thr Thr Arg His Gly Thr Leu Leu Gly Pro Ala Ala Arg Leu Val Gln 
        275                 280                 285             


Val Asp Val Glu Gln Ala Ala Leu Gly Ala His Arg Pro Ile Asp Leu 
    290                 295                 300                 


Gly Val Val Gly Asp Val Ala Gly Thr Ala Val Asp Val His Ala Glu 
305                 310                 315                 320 


Leu Asp Lys Arg Gly His Gln Arg Ser Arg Glu Ala Pro Thr Gly Thr 
                325                 330                 335     


Arg Trp Asn Asp Val Pro Tyr Asn Asp Leu Ser Gly Asp Gly Arg Ile 
            340                 345                 350         


Asp Pro Arg Thr Leu Ser Arg Arg Leu Asp Glu Ile Leu Pro Ala Glu 
        355                 360                 365             


Arg Met Val Ser Ile Asp Ser Gly Asn Phe Met Gly Tyr Pro Ser Ala 
    370                 375                 380                 


Tyr Leu Ser Val Pro Asp Glu Asn Gly Phe Cys Phe Thr Gln Ala Phe 
385                 390                 395                 400 


Gln Ser Ile Gly Leu Gly Leu Gly Thr Ala Ile Gly Ala Ala Leu Ala 
                405                 410                 415     


Arg Pro Asp Arg Leu Pro Val Leu Gly Val Gly Asp Gly Gly Phe His 
            420                 425                 430         


Met Ala Val Ser Glu Leu Glu Thr Ala Val Arg Leu Arg Ile Pro Leu 
        435                 440                 445             


Val Ile Val Val Tyr Asn Asp Ala Ala Tyr Gly Ala Glu Ile His His 
    450                 455                 460                 


Phe Gly Asp Ala Asp Met Thr Thr Val Arg Phe Pro Asp Thr Asp Ile 
465                 470                 475                 480 


Ala Ala Ile Gly Arg Gly Phe Gly Cys Asp Gly Val Thr Val Arg Ser 
                485                 490                 495     


Val Gly Asp Leu Ala Ala Val Lys Glu Trp Leu Gly Gly Pro Arg Asp 
            500                 505                 510         


Ala Pro Leu Val Ile Asp Ala Lys Ile Ala Asp Asp Gly Gly Ser Trp 
        515                 520                 525             


Trp Leu Ala Glu Ala Phe Arg His 
    530                 535     


<210>  10
<211>  584
<212>  PRT
<213>  Actinoplanes missouriensis

<400>  10

Met Ile Asp Leu Asp Gly Thr Val Thr Val Ala Glu Tyr Leu Gly Leu 
1               5                   10                  15      


Arg Leu Arg His Ala Gly Val Glu His Leu Phe Gly Val Pro Gly Asp 
            20                  25                  30          


Phe Asn Leu Asn Leu Leu Asp Gly Leu Ala Phe Val Glu Gly Leu Arg 
        35                  40                  45              


Trp Val Gly Ser Pro Asn Glu Leu Gly Ala Gly Tyr Ala Ala Asp Ala 
    50                  55                  60                  


Tyr Ala Arg Arg Arg Gly Leu Ser Ala Leu Phe Thr Thr Tyr Gly Val 
65                  70                  75                  80  


Gly Glu Leu Ser Ala Ile Asn Ala Val Ala Gly Ser Ala Ala Glu Asp 
                85                  90                  95      


Ser Pro Val Val His Val Val Gly Ser Pro Arg Thr Thr Thr Val Ala 
            100                 105                 110         


Gly Gly Ala Leu Val His His Thr Ile Ala Asp Gly Asp Phe Arg His 
        115                 120                 125             


Phe Ala Arg Ala Tyr Ala Glu Val Thr Val Ala Gln Ala Met Val Thr 
    130                 135                 140                 


Ala Thr Asp Ala Gly Ala Gln Ile Asp Arg Val Leu Leu Ala Ala Leu 
145                 150                 155                 160 


Thr His Arg Lys Pro Val Tyr Leu Ser Ile Pro Gln Asp Leu Ala Leu 
                165                 170                 175     


His Arg Ile Pro Ala Ala Pro Leu Arg Glu Pro Leu Thr Pro Ala Ser 
            180                 185                 190         


Asp Pro Ala Ala Val Glu Arg Phe Arg Thr Ala Val Arg Asp Leu Leu 
        195                 200                 205             


Thr Pro Ala Val Arg Pro Ile Met Leu Val Gly Gln Leu Val Ser Arg 
    210                 215                 220                 


Tyr Gly Leu Ser Thr Leu Val Thr Asp Met Thr Thr Arg Ser Gly Ile 
225                 230                 235                 240 


Pro Val Ala Ala Gln Leu Ser Ala Lys Gly Val Ile Asp Glu Ser Val 
                245                 250                 255     


Glu Gly Asn Leu Gly Leu Tyr Ala Gly Ser Met Leu Asp Gly Pro Ala 
            260                 265                 270         


Ala Ser Leu Ile Asp Ser Ala Asp Val Val Leu His Leu Gly Thr Ala 
        275                 280                 285             


Leu Thr Ala Glu Leu Thr Gly Phe Phe Thr His Arg Arg Pro Asp Ala 
    290                 295                 300                 


Arg Thr Val Gln Leu Leu Ser Thr Ala Ala Leu Val Gly Thr Thr Arg 
305                 310                 315                 320 


Phe Asp Asn Val Leu Phe Pro Asp Ala Met Thr Thr Leu Ala Glu Val 
                325                 330                 335     


Leu Thr Thr Phe Pro Ala Pro Ala Arg Leu Ala Ala Pro Thr Thr Arg 
            340                 345                 350         


Ala Glu Pro Thr Gly Leu Ala Ala Ser Ile Thr Pro Pro Ala Pro Ser 
        355                 360                 365             


Ala Val Asp Leu Thr Ala Ser Thr Ala Thr Asp Leu Thr Ala Pro Thr 
    370                 375                 380                 


Ala Gly Asp Ile Ser Glu Met Ser Arg Val Leu Thr Gln Asp Ala Phe 
385                 390                 395                 400 


Trp Ala Gly Met Gln Ala Trp Leu Pro Ala Gly His Ala Leu Val Ala 
                405                 410                 415     


Asp Thr Gly Thr Ser Tyr Trp Gly Ala Leu Ala Leu Arg Leu Pro Gly 
            420                 425                 430         


Asp Thr Val Phe Leu Gly Gln Pro Ile Trp Asn Ser Ile Gly Trp Ala 
        435                 440                 445             


Leu Pro Ala Val Leu Gly Gln Gly Leu Ala Asp Pro Asp Arg Arg Pro 
    450                 455                 460                 


Val Leu Val Ile Gly Asp Gly Ala Ala Gln Met Thr Ile Gln Glu Leu 
465                 470                 475                 480 


Ser Thr Ile Val Ala Ala Gly Leu Arg Pro Ile Ile Leu Leu Leu Asn 
                485                 490                 495     


Asn Arg Gly Tyr Thr Ile Glu Arg Ala Leu Gln Ser Pro Asn Ala Gly 
            500                 505                 510         


Tyr Asn Asp Val Ala Asp Trp Asn Trp Arg Ala Val Val Ala Ala Phe 
        515                 520                 525             


Ala Gly Pro Asp Thr Asp Tyr His His Ala Ala Thr Gly Thr Glu Leu 
    530                 535                 540                 


Ala Lys Ala Leu Thr Ala Ala Ser Glu Ser Asn Arg Pro Val Phe Ile 
545                 550                 555                 560 


Glu Val Glu Leu Asp Ala Phe Asp Thr Pro Pro Leu Leu Arg Arg Leu 
                565                 570                 575     


Ala Glu Arg Ala Thr Ala Pro Ser 
            580                 


<210>  11
<211>  546
<212>  PRT
<213>  Staphylococcus aureus

<400>  11

Met Lys Gln Arg Ile Gly Ala Tyr Leu Ile Asp Ala Ile His Arg Ala 
1               5                   10                  15      


Gly Val Asp Lys Ile Phe Gly Val Pro Gly Asp Phe Asn Leu Ala Phe 
            20                  25                  30          


Leu Asp Asp Ile Ile Ser Asn Pro Asn Val Asp Trp Val Gly Asn Thr 
        35                  40                  45              


Asn Glu Leu Asn Ala Ser Tyr Ala Ala Asp Gly Tyr Ala Arg Leu Asn 
    50                  55                  60                  


Gly Leu Ala Ala Leu Val Thr Thr Phe Gly Val Gly Glu Leu Ser Ala 
65                  70                  75                  80  


Val Asn Gly Ile Ala Gly Ser Tyr Ala Glu Arg Ile Pro Val Ile Ala 
                85                  90                  95      


Ile Thr Gly Ala Pro Thr Arg Ala Val Glu His Ala Gly Lys Tyr Val 
            100                 105                 110         


His His Ser Leu Gly Glu Gly Thr Phe Asp Asp Tyr Arg Lys Met Phe 
        115                 120                 125             


Ala His Ile Thr Val Ala Gln Gly Tyr Ile Thr Pro Glu Asn Ala Thr 
    130                 135                 140                 


Thr Glu Ile Pro Arg Leu Ile Asn Thr Ala Ile Ala Glu Arg Arg Pro 
145                 150                 155                 160 


Val His Leu His Leu Pro Ile Asp Val Ala Ile Ser Glu Ile Glu Ile 
                165                 170                 175     


Pro Thr Pro Phe Glu Val Thr Ala Ala Lys Asp Thr Asp Ala Ser Thr 
            180                 185                 190         


Tyr Ile Glu Leu Leu Thr Ser Lys Leu His Gln Ser Lys Gln Pro Ile 
        195                 200                 205             


Ile Ile Thr Gly His Glu Ile Asn Ser Phe His Leu His Gln Glu Leu 
    210                 215                 220                 


Glu Asp Phe Val Asn Gln Thr Gln Ile Pro Val Ala Gln Leu Ser Leu 
225                 230                 235                 240 


Gly Lys Gly Ala Phe Asn Glu Glu Asn Pro Tyr Tyr Met Gly Ile Tyr 
                245                 250                 255     


Asp Gly Lys Ile Ala Glu Asp Lys Ile Arg Asp Tyr Val Asp Asn Ser 
            260                 265                 270         


Asp Leu Ile Leu Asn Ile Gly Ala Lys Leu Thr Asp Ser Ala Thr Ala 
        275                 280                 285             


Gly Phe Ser Tyr Gln Phe Asn Ile Asp Asp Val Val Met Leu Asn His 
    290                 295                 300                 


His Asn Ile Lys Ile Asp Asp Val Thr Asn Asp Glu Ile Ser Leu Pro 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Leu Ser Asn Ile Ser His Thr Asn Asn Ala Thr 
                325                 330                 335     


Phe Pro Ala Tyr His Arg Pro Thr Ser Pro Asp Tyr Thr Val Gly Thr 
            340                 345                 350         


Glu Pro Leu Thr Gln Gln Thr Tyr Phe Lys Met Met Gln Asn Phe Leu 
        355                 360                 365             


Lys Pro Asn Asp Val Ile Ile Ala Asp Gln Gly Thr Ser Phe Phe Gly 
    370                 375                 380                 


Ala Tyr Asp Leu Ala Leu Tyr Lys Asn Asn Thr Phe Ile Gly Gln Pro 
385                 390                 395                 400 


Leu Trp Gly Ser Ile Gly Tyr Thr Leu Pro Ala Thr Leu Gly Ser Gln 
                405                 410                 415     


Leu Ala Asp Lys Asp Arg Arg Asn Leu Leu Leu Ile Gly Asp Gly Ser 
            420                 425                 430         


Leu Gln Leu Thr Val Gln Ala Ile Ser Thr Met Ile Arg Gln His Ile 
        435                 440                 445             


Lys Pro Val Leu Phe Val Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg 
    450                 455                 460                 


Leu Ile His Gly Met Tyr Glu Pro Tyr Asn Glu Ile His Met Trp Asp 
465                 470                 475                 480 


Tyr Lys Ala Leu Pro Ala Val Phe Gly Gly Lys Asn Val Glu Ile His 
                485                 490                 495     


Asp Val Glu Ser Ser Lys Asp Leu Gln Asp Thr Phe Asn Ala Ile Asn 
            500                 505                 510         


Gly His Pro Asp Val Met His Phe Val Glu Val Lys Met Ser Val Glu 
        515                 520                 525             


Asp Ala Pro Lys Lys Leu Ile Asp Ile Ala Lys Ala Phe Ser Gln Gln 
    530                 535                 540                 


Asn Lys 
545     


<210>  12
<211>  528
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  12

Met Lys Thr Val His Ser Ala Ser Tyr Glu Ile Leu Arg Arg His Gly 
1               5                   10                  15      


Leu Thr Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Gly Leu His Glu Gly 
        35                  40                  45              


Ala Val Val Gly Met Ala Asp Gly Phe Ala Leu Ala Ser Gly Arg Pro 
    50                  55                  60                  


Ala Phe Val Asn Leu His Ala Ala Ala Gly Thr Gly Asn Gly Met Gly 
65                  70                  75                  80  


Ala Leu Thr Asn Ala Trp Tyr Ser His Ser Pro Leu Val Ile Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Ser Met Ile Gly Val Glu Ala Met Leu Ala Asn 
            100                 105                 110         


Val Asp Ala Gly Gln Leu Pro Lys Pro Leu Val Lys Trp Ser His Glu 
        115                 120                 125             


Pro Ala Cys Ala Gln Asp Val Pro Arg Ala Leu Ser Gln Ala Ile Gln 
    130                 135                 140                 


Thr Ala Ser Leu Pro Pro Arg Ala Pro Val Tyr Leu Ser Ile Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Ala Gln Pro Ala Pro Ala Gly Val Glu His Leu Ala Ala 
                165                 170                 175     


Arg Gln Val Ser Gly Ala Ala Leu Pro Ala Pro Ala Leu Leu Ala Glu 
            180                 185                 190         


Leu Gly Glu Arg Leu Ser Arg Ser Arg Asn Pro Val Leu Val Leu Gly 
        195                 200                 205             


Pro Asp Val Asp Gly Ala Asn Ala Asn Gly Leu Ala Val Glu Leu Ala 
    210                 215                 220                 


Glu Lys Leu Arg Met Pro Ala Trp Gly Ala Pro Ser Ala Ser Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Ala Cys Phe Arg Gly Val Leu Pro Ala Ala 
                245                 250                 255     


Ile Ala Gly Ile Ser Arg Leu Leu Asp Gly His Asp Leu Ile Leu Val 
            260                 265                 270         


Val Gly Ala Pro Val Phe Arg Tyr His Gln Phe Ala Pro Gly Asp Tyr 
        275                 280                 285             


Leu Pro Ala Gly Ala Glu Leu Val Gln Val Thr Cys Asp Pro Gly Glu 
    290                 295                 300                 


Ala Ala Arg Ala Pro Met Gly Asp Ala Leu Val Gly Asp Ile Ala Leu 
305                 310                 315                 320 


Thr Leu Glu Ala Leu Leu Glu Gln Val Arg Pro Ser Ala Arg Pro Leu 
                325                 330                 335     


Pro Glu Ala Leu Pro Arg Pro Pro Ala Leu Ala Glu Glu Gly Gly Pro 
            340                 345                 350         


Leu Arg Pro Glu Thr Val Phe Asp Val Ile Asp Ala Leu Ala Pro Arg 
        355                 360                 365             


Asp Ala Ile Phe Val Lys Glu Ser Thr Ser Thr Val Thr Ala Phe Trp 
    370                 375                 380                 


Gln Arg Val Glu Met Arg Glu Pro Gly Ser Tyr Phe Phe Pro Ala Ala 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Gly Leu Pro Ala Ala Val Gly Ala Gln Leu Ala 
                405                 410                 415     


Gln Pro Arg Arg Gln Val Ile Gly Ile Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Gly Ile Thr Ala Leu Trp Ser Ala Ala Gln Tyr Arg Val Pro Ala 
        435                 440                 445             


Val Phe Ile Ile Leu Lys Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 


Ala Gly Val Leu Glu Val Pro Asp Ala Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Leu Asp Phe Cys Ala Ile Ala Arg Gly Tyr Gly Val Glu Ala Leu His 
                485                 490                 495     


Ala Ala Thr Arg Glu Glu Leu Glu Gly Ala Leu Lys His Ala Leu Ala 
            500                 505                 510         


Ala Asp Arg Pro Val Leu Ile Glu Val Pro Thr Gln Thr Ile Glu Pro 
        515                 520                 525             


<210>  13
<211>  548
<212>  PRT
<213>  Carnobacterium maltaromaticum

<400>  13

Met Tyr Thr Val Gly Asn Tyr Leu Leu Asp Arg Leu Thr Glu Leu Gly 
1               5                   10                  15      


Ile Arg Asp Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Lys Phe Leu 
            20                  25                  30          


Asp His Val Met Thr His Lys Glu Leu Asn Trp Ile Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Thr Lys Gly 
    50                  55                  60                  


Ile Ala Ala Leu Val Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ala 
65                  70                  75                  80  


Asn Gly Thr Ala Gly Ser Tyr Ala Glu Lys Val Pro Val Val Gln Ile 
                85                  90                  95      


Val Gly Thr Pro Thr Thr Ala Val Gln Asn Ser His Lys Leu Val His 
            100                 105                 110         


His Thr Leu Gly Asp Gly Arg Phe Asp His Phe Glu Lys Met Gln Thr 
        115                 120                 125             


Glu Ile Asn Gly Ala Ile Ala His Leu Thr Ala Asp Asn Ala Leu Ala 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Arg Ile Ala Val Thr Glu Arg Cys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Ala Ile Asp Val Ala Glu Val Val Ala Glu Lys Pro 
                165                 170                 175     


Leu Lys Pro Leu Met Glu Glu Ser Lys Lys Val Glu Glu Glu Thr Thr 
            180                 185                 190         


Leu Val Leu Asn Lys Ile Glu Lys Ala Leu Gln Asp Ser Lys Asn Pro 
        195                 200                 205             


Val Val Leu Ile Gly Asn Glu Ile Ala Ser Phe His Leu Glu Ser Ala 
    210                 215                 220                 


Leu Ala Asp Phe Val Lys Lys Phe Asn Leu Pro Val Thr Val Leu Pro 
225                 230                 235                 240 


Phe Gly Lys Gly Gly Phe Asp Glu Glu Asp Ala His Phe Ile Gly Val 
                245                 250                 255     


Tyr Thr Gly Ala Pro Thr Ala Glu Ser Ile Lys Glu Arg Val Glu Lys 
            260                 265                 270         


Ala Asp Leu Ile Leu Ile Ile Gly Ala Lys Leu Thr Asp Ser Ala Thr 
        275                 280                 285             


Ala Gly Phe Ser Tyr Asp Phe Glu Asp Arg Gln Val Ile Ser Val Gly 
    290                 295                 300                 


Ser Asp Glu Val Ser Phe Tyr Gly Glu Ile Met Lys Pro Val Ala Phe 
305                 310                 315                 320 


Ala Gln Phe Val Asn Gly Leu Asn Ser Leu Asn Tyr Leu Gly Tyr Thr 
                325                 330                 335     


Gly Glu Ile Lys Gln Val Glu Arg Val Ala Asp Ile Glu Ala Lys Ala 
            340                 345                 350         


Ser Asn Leu Thr Gln Asn Asn Phe Trp Lys Phe Val Glu Lys Tyr Leu 
        355                 360                 365             


Ser Asn Gly Asp Thr Leu Val Ala Glu Gln Gly Thr Ser Phe Phe Gly 
    370                 375                 380                 


Ala Ser Leu Val Pro Leu Lys Ser Lys Met Lys Phe Ile Gly Gln Pro 
385                 390                 395                 400 


Leu Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Met Leu Gly Ser Gln 
                405                 410                 415     


Ile Ala Asn Pro Ala Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser 
            420                 425                 430         


Leu Gln Leu Thr Ile Gln Glu Leu Gly Met Thr Phe Arg Glu Lys Leu 
        435                 440                 445             


Thr Pro Ile Val Phe Val Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg 
    450                 455                 460                 


Glu Ile His Gly Pro Asn Glu Leu Tyr Asn Asp Ile Pro Met Trp Asp 
465                 470                 475                 480 


Tyr Gln Asn Leu Pro Tyr Val Phe Gly Gly Asn Lys Gly Asn Val Ala 
                485                 490                 495     


Thr Tyr Lys Val Thr Thr Glu Glu Glu Leu Val Ala Ala Met Ser Gln 
            500                 505                 510         


Ala Arg Gln Asp Thr Thr Arg Leu Gln Trp Ile Glu Val Val Met Gly 
        515                 520                 525             


Lys Gln Asp Ser Pro Asp Leu Leu Val Gln Leu Gly Lys Val Phe Ala 
    530                 535                 540                 


Lys Gln Asn Ser 
545             


<210>  14
<211>  529
<212>  PRT
<213>  Klebsiella sp. 1_1_55

<400>  14

Met Lys Thr Ile His Ser Ala Ala Tyr Ala Leu Leu Arg Arg His Gly 
1               5                   10                  15      


Met Thr Thr Ile Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Lys Ser Phe Pro Glu Asp Phe Gln Tyr Val Leu Gly Leu His Glu Gly 
        35                  40                  45              


Ala Val Val Gly Met Ala Asp Gly Tyr Ala Leu Ala Ser Gly Lys Pro 
    50                  55                  60                  


Ala Phe Val Asn Leu His Ala Ala Ala Gly Thr Gly Asn Gly Met Gly 
65                  70                  75                  80  


Ala Leu Thr Asn Ser Trp Tyr Ser His Ser Pro Leu Val Ile Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Pro Met Ile Gly Val Glu Ala Met Leu Ala Asn 
            100                 105                 110         


Val Asp Ala Thr Gln Leu Pro Lys Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             


Pro Ala Asn Ala Gln Asp Val Pro Arg Ala Leu Ser Gln Ala Ile His 
    130                 135                 140                 


Tyr Ala Asn Thr Thr Pro Lys Ala Pro Val Tyr Leu Ser Ile Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Asp Gln Pro Ser Gly Pro Gly Val Glu His Leu Ile Glu 
                165                 170                 175     


Arg Asp Val Gln Thr Ala Gly Thr Pro Asp Ala Arg Gln Leu Gln Val 
            180                 185                 190         


Leu Val Gln Gln Val Gln Asp Ala Arg Asn Pro Val Leu Val Leu Gly 
        195                 200                 205             


Pro Asp Val Asp Ala Thr Leu Ser Asn Asp His Ala Val Ala Leu Ala 
    210                 215                 220                 


Asp Lys Leu Arg Met Pro Val Trp Ile Ala Pro Ser Ala Ser Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Pro Ser Phe Arg Gly Val Leu Pro Ala Ala 
                245                 250                 255     


Ile Ala Gly Ile Ser Lys Thr Leu Gln Gly His Asp Leu Ile Ile Val 
            260                 265                 270         


Val Gly Ala Pro Val Phe Arg Tyr His Gln Phe Ala Pro Gly Asp Tyr 
        275                 280                 285             


Leu Pro Val Gly Ala Gln Leu Leu His Ile Thr Ser Asp Pro Leu Glu 
    290                 295                 300                 


Ala Thr Arg Ala Pro Met Gly His Ala Leu Val Gly Asp Ile Arg Glu 
305                 310                 315                 320 


Thr Leu Arg Val Leu Ala Glu Glu Val Val Gln Gln Ser Arg Pro Tyr 
                325                 330                 335     


Pro Glu Ala Leu Ala Ala Pro Glu Cys Val Thr Asp Glu Pro His His 
            340                 345                 350         


Leu His Pro Glu Thr Leu Phe Asp Val Leu Asp Ala Val Ala Pro His 
        355                 360                 365             


Asp Ala Ile Tyr Val Lys Glu Ser Thr Ser Thr Thr Thr Ala Phe Trp 
    370                 375                 380                 


Gln Arg Met Asn Leu Arg His Pro Gly Ser Tyr Tyr Phe Pro Ala Ala 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Gly Leu Pro Ala Ala Val Gly Val Gln Leu Ala 
                405                 410                 415     


Gln Pro Gln Arg Arg Val Val Ala Leu Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Gly Ile Thr Ala Leu Trp Thr Ala Ala Gln Tyr Arg Ile Pro Val 
        435                 440                 445             


Val Phe Ile Ile Leu Lys Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 


Ala Gly Val Leu Lys Ala Glu Asp Ser Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Leu Asp Phe Cys Ala Ile Ala Lys Gly Tyr Gly Val Lys Ala Val His 
                485                 490                 495     


Thr Asp Thr Arg Asp Ser Phe Glu Ala Ala Leu Arg Thr Ala Leu Asp 
            500                 505                 510         


Ala Asn Glu Pro Thr Val Ile Glu Val Pro Thr Leu Thr Ile Gln Pro 
        515                 520                 525             


His 
    


<210>  15
<211>  564
<212>  PRT
<213>  Klebsiella sp. 1_1_55

<400>  15

Met Ser Asn Ala Ile Thr Lys Val Gln Asn Ala Asn Ala Arg Arg Gly 
1               5                   10                  15      


Gly Asp Val Leu Leu Glu Val Leu Glu Ser Glu Gly Val Glu Tyr Val 
            20                  25                  30          


Phe Gly Asn Pro Gly Thr Thr Glu Leu Pro Phe Met Asp Ala Leu Leu 
        35                  40                  45              


Arg Lys Pro Ser Ile Gln Tyr Val Leu Ala Leu Gln Glu Ala Ser Ala 
    50                  55                  60                  


Val Ala Met Ala Asp Gly Tyr Ala Gln Ala Ala Lys Lys Pro Gly Phe 
65                  70                  75                  80  


Leu Asn Leu His Thr Ala Gly Gly Leu Gly His Gly Met Gly Asn Leu 
                85                  90                  95      


Leu Asn Ala Lys Cys Ser Gln Thr Pro Leu Val Val Thr Ala Gly Gln 
            100                 105                 110         


Gln Asp Ser Arg His Thr Thr Thr Asp Pro Leu Leu Leu Gly Asp Leu 
        115                 120                 125             


Val Gly Met Gly Lys Thr Phe Ala Lys Trp Ser Gln Glu Val Thr His 
    130                 135                 140                 


Val Asp Gln Leu Pro Val Leu Val Arg Arg Ala Phe His Asp Ser Asp 
145                 150                 155                 160 


Ala Ala Pro Lys Gly Ser Val Phe Leu Ser Leu Pro Met Asp Val Met 
                165                 170                 175     


Glu Ala Met Ser Ala Ile Gly Ile Gly Ala Pro Ser Thr Ile Asp Arg 
            180                 185                 190         


Asn Ala Val Ala Gly Ser Leu Pro Leu Leu Ala Ser Lys Leu Ala Ala 
        195                 200                 205             


Phe Thr Pro Gly Asn Val Ala Leu Ile Ala Gly Asp Glu Ile Tyr Gln 
    210                 215                 220                 


Ser Glu Ala Ala Asn Glu Val Val Ala Leu Ala Glu Met Leu Ala Ala 
225                 230                 235                 240 


Asp Val Tyr Gly Ser Thr Trp Pro Asn Arg Ile Pro Tyr Pro Thr Ala 
                245                 250                 255     


His Pro Leu Trp Arg Gly Asn Leu Ser Thr Lys Ala Thr Glu Ile Asn 
            260                 265                 270         


Arg Ala Leu Ser Gln Tyr Asp Ala Ile Phe Ala Leu Gly Gly Lys Ser 
        275                 280                 285             


Leu Ile Thr Ile Leu Tyr Thr Glu Gly Gln Ala Val Pro Glu Gln Cys 
    290                 295                 300                 


Lys Val Phe Gln Leu Ser Ala Asp Ala Gly Asp Leu Gly Arg Thr Tyr 
305                 310                 315                 320 


Ser Ser Glu Leu Ser Val Val Gly Asp Ile Lys Ser Ser Leu Lys Val 
                325                 330                 335     


Leu Leu Pro Glu Leu Glu Lys Ala Thr Ala Asn His Arg Arg Asp Tyr 
            340                 345                 350         


Gln Arg Arg Phe Glu Lys Ala Ile Asn Glu Phe Lys Leu Ser Lys Glu 
        355                 360                 365             


Ser Leu Leu Gly Gln Val Gln Glu Gln Gln Ser Ala Thr Val Ile Thr 
    370                 375                 380                 


Pro Leu Val Ala Ala Phe Glu Ala Ala Arg Ala Ile Gly Pro Asp Val 
385                 390                 395                 400 


Ala Ile Val Asp Glu Ala Ile Ala Thr Ser Gly Ser Leu Arg Lys Ser 
                405                 410                 415     


Leu Asn Ser His Arg Ala Asp Gln Tyr Ala Phe Leu Arg Gly Gly Gly 
            420                 425                 430         


Leu Gly Trp Gly Met Pro Ala Ala Val Gly Tyr Ser Leu Gly Leu Gly 
        435                 440                 445             


Lys Ala Pro Val Val Cys Phe Val Gly Asp Gly Ala Ala Met Tyr Ser 
    450                 455                 460                 


Pro Gln Ala Leu Trp Thr Ala Ala His Glu Lys Leu Pro Val Thr Phe 
465                 470                 475                 480 


Ile Val Met Asn Asn Thr Glu Tyr Asn Val Leu Lys Asn Phe Met Arg 
                485                 490                 495     


Ser Gln Ala Asp Tyr Thr Ser Ala Gln Thr Asp Arg Phe Ile Ala Met 
            500                 505                 510         


Asp Leu Val Asn Pro Ser Val Asp Tyr Gln Ala Leu Gly Ala Ser Met 
        515                 520                 525             


Gly Leu Glu Thr Arg Lys Val Ile Arg Ala Gly Asp Ile Ala Pro Ala 
    530                 535                 540                 


Val Glu Ala Ala Leu Ala Ser Gly Lys Pro Asn Val Ile Glu Ile Ile 
545                 550                 555                 560 


Ile Ser Lys Ser 
                


<210>  16
<211>  566
<212>  PRT
<213>  Burkholderia sp. Ch1-1

<400>  16

Met Thr Ser Arg Ser Ser Phe Ser Pro Pro Ser Ala Ser Glu Gln Arg 
1               5                   10                  15      


Gly Ala Asp Ile Phe Ala Glu Val Leu Gln Cys Glu Gly Val Arg Tyr 
            20                  25                  30          


Ile Phe Gly Asn Pro Gly Thr Thr Glu Leu Pro Leu Leu Asp Ala Leu 
        35                  40                  45              


Thr Asp Ile Thr Gly Ile His Tyr Val Leu Gly Leu His Glu Ala Ser 
    50                  55                  60                  


Val Val Ala Met Ala Asp Gly Tyr Ala Gln Ala Ser Gly Lys Pro Gly 
65                  70                  75                  80  


Phe Val Asn Leu His Thr Ala Gly Gly Leu Gly Asn Ala Met Gly Ala 
                85                  90                  95      


Ile Leu Asn Ala Lys Met Ala Asn Thr Pro Leu Val Val Thr Ala Gly 
            100                 105                 110         


Gln Gln Asp Thr Arg His Gly Val Thr Asp Pro Leu Leu His Gly Asp 
        115                 120                 125             


Leu Thr Gly Ile Ala Arg Pro Asn Val Lys Trp Ala Glu Glu Ile His 
    130                 135                 140                 


His Pro Glu His Ile Pro Met Leu Leu Arg Arg Ala Leu Gln Asp Cys 
145                 150                 155                 160 


Arg Thr Gly Pro Ala Gly Pro Val Phe Leu Ser Leu Pro Ile Asp Thr 
                165                 170                 175     


Met Glu Arg Cys Thr Ser Val Gly Ala Gly Glu Ala Ser Arg Ile Glu 
            180                 185                 190         


Arg Ala Ser Val Ala Asn Met Leu His Ala Leu Ala Thr Ala Leu Ala 
        195                 200                 205             


Glu Val Thr Ala Gly His Ile Ala Leu Val Ala Gly Glu Glu Val Phe 
    210                 215                 220                 


Thr Ala Asn Ala Ser Val Glu Ala Val Ala Leu Ala Glu Ala Leu Gly 
225                 230                 235                 240 


Ala Pro Val Phe Gly Ala Ser Trp Pro Gly His Ile Pro Phe Pro Thr 
                245                 250                 255     


Ala His Pro Gln Trp Gln Gly Thr Leu Pro Pro Lys Ala Ser Asp Ile 
            260                 265                 270         


Arg Glu Thr Leu Gly Pro Phe Asp Ala Val Leu Ile Leu Gly Gly His 
        275                 280                 285             


Ser Leu Ile Ser Tyr Pro Tyr Ser Glu Gly Pro Ala Ile Pro Pro His 
    290                 295                 300                 


Cys Arg Leu Phe Gln Leu Thr Gly Asp Gly His Gln Ile Gly Arg Val 
305                 310                 315                 320 


His Glu Thr Thr Leu Gly Leu Val Gly Asp Leu Gln Leu Ser Leu Arg 
                325                 330                 335     


Ala Leu Leu Pro Leu Leu Ala Arg Lys Leu Gln Pro Gln Asn Gly Ala 
            340                 345                 350         


Val Ala Arg Leu Arg Gln Val Ala Thr Leu Lys Arg Asp Ala Arg Arg 
        355                 360                 365             


Thr Glu Ala Ala Glu Arg Ser Ala Arg Glu Phe Asp Ala Ser Ala Thr 
    370                 375                 380                 


Thr Pro Phe Val Ala Ala Phe Glu Thr Ile Arg Ala Ile Gly Pro Asp 
385                 390                 395                 400 


Val Pro Ile Val Asp Glu Ala Pro Val Thr Ile Pro His Val Arg Ala 
                405                 410                 415     


Cys Leu Asp Ser Ala Ser Ala Arg Gln Tyr Leu Phe Thr Arg Ser Ala 
            420                 425                 430         


Ile Leu Gly Trp Gly Met Pro Ala Ala Val Gly Val Ser Leu Gly Leu 
        435                 440                 445             


Asp Arg Ser Pro Val Val Cys Leu Val Gly Asp Gly Ser Ala Met Tyr 
    450                 455                 460                 


Ser Pro Gln Ala Leu Trp Thr Ala Ala His Glu Arg Leu Pro Val Thr 
465                 470                 475                 480 


Phe Val Val Phe Asn Asn Gly Glu Tyr Asn Ile Leu Lys Asn Tyr Ala 
                485                 490                 495     


Arg Ala Gln Thr Asn Tyr Arg Ser Ala Arg Ala Asn Arg Phe Ile Gly 
            500                 505                 510         


Leu Asp Ile Ser Asp Pro Ala Ile Asp Phe Pro Ala Leu Ala Ser Ser 
        515                 520                 525             


Leu Gly Val Pro Ala Arg Arg Val Glu Arg Ala Gly Asp Ile Ala Ile 
    530                 535                 540                 


Ala Val Glu Asp Gly Ile Arg Ser Gly Arg Pro Asn Leu Ile Asp Val 
545                 550                 555                 560 


Leu Ile Ser Ser Ser Ser 
                565     


<210>  17
<211>  562
<212>  PRT
<213>  Granulicella mallensis

<400>  17

Met Asn Ile Ala Tyr Glu Thr Arg Glu Asn Lys Val Ala Ser Gly Arg 
1               5                   10                  15      


Glu Cys Leu Leu Glu Ile Leu Arg Asp Glu Gly Val Thr His Val Phe 
            20                  25                  30          


Gly Asn Pro Gly Thr Thr Glu Leu Ala Leu Ile Asp Ala Leu Ala Gly 
        35                  40                  45              


Asp Asp Asp Phe His Phe Ile Leu Gly Leu Gln Glu Ala Ala Val Val 
    50                  55                  60                  


Gly Met Ala Asp Gly Tyr Ala Gln Ala Thr Gly Arg Pro Ser Phe Val 
65                  70                  75                  80  


Asn Leu His Thr Thr Ala Gly Leu Gly Asn Gly Met Gly Asn Leu Thr 
                85                  90                  95      


Asn Ala Phe Ala Thr Asn Val Pro Met Val Val Thr Ala Gly Gln Gln 
            100                 105                 110         


Asp Ile Arg His Leu Ala Tyr Asp Pro Leu Leu Ser Gly Asp Leu Val 
        115                 120                 125             


Gly Leu Ala Arg Ala Thr Val Lys Trp Ala His Glu Val Arg Ser Leu 
    130                 135                 140                 


Gln Glu Leu Pro Ile Ile Leu Arg Arg Ala Phe Arg Asp Ala Asn Thr 
145                 150                 155                 160 


Glu Pro Arg Gly Pro Val Phe Val Ser Leu Pro Met Asn Ile Ile Asp 
                165                 170                 175     


Glu Ile Gly Thr Val Ser Ile Pro Pro Arg Ser Thr Ile Val Gln Ala 
            180                 185                 190         


Glu Ser Gly Asp Ile Ser Gln Leu Val Arg Leu Leu Val Glu Ser Ala 
        195                 200                 205             


Gly Asn Leu Cys Leu Val Val Gly Asp Glu Val Gly Arg Tyr Gly Ala 
    210                 215                 220                 


Thr Glu Ala Ala Val Arg Val Ala Glu Leu Leu Gly Ala Pro Val Tyr 
225                 230                 235                 240 


Gly Ser Pro Phe His Ser Asn Val Pro Phe Pro Thr Asp His Pro Leu 
                245                 250                 255     


Trp Arg Phe Thr Leu Pro Pro Asn Thr Gly Glu Met Arg Lys Val Leu 
            260                 265                 270         


Gly Gly Tyr Asp Arg Ile Leu Leu Ile Gly Asp Arg Ala Phe Met Ser 
        275                 280                 285             


Tyr Thr Tyr Ser Asp Glu Leu Pro Leu Ser Pro Lys Thr Gln Leu Leu 
    290                 295                 300                 


Gln Ile Ala Val Asp Arg His Ser Leu Gly Arg Cys His Ala Val Glu 
305                 310                 315                 320 


Leu Gly Leu Tyr Gly Asp Pro Leu Ser Leu Leu Ala Ala Val Gly Asp 
                325                 330                 335     


Ala Leu Ser Gln Glu Arg Ala Leu Ala Pro Ser Arg Asp Ser Arg Leu 
            340                 345                 350         


Ala Ile Ala Arg Asp Trp Arg Ala Ser Trp Glu Gln Asp Leu Lys Asp 
        355                 360                 365             


Glu Cys Glu Arg Leu Ala Pro Ser Arg Pro Leu Tyr Pro Leu Val Ala 
    370                 375                 380                 


Ala Asp Ala Val Leu Arg Gly Val Pro Pro Gly Thr Val Ile Val Asp 
385                 390                 395                 400 


Glu Cys Leu Ala Thr Asn Lys Tyr Val Arg Gln Leu Tyr Pro Val Arg 
                405                 410                 415     


Lys Pro Gly Glu Tyr Tyr Tyr Phe Arg Gly Ala Gly Leu Gly Trp Gly 
            420                 425                 430         


Met Pro Ala Ala Val Gly Val Ser Leu Gly Leu Glu Arg Gln Gln Arg 
        435                 440                 445             


Val Val Cys Leu Leu Gly Asp Gly Ala Ala Met Tyr Ser Pro Gln Ala 
    450                 455                 460                 


Leu Trp Ser Ala Ala His Glu Ser Leu Pro Ile Thr Phe Val Val Phe 
465                 470                 475                 480 


Asn Asn Ser Glu Tyr Asn Ile Leu Lys Asn Phe Met Arg Ser Arg Pro 
                485                 490                 495     


Gly Tyr Asn Ala Gln Ser Gly Arg Phe Val Gly Met Glu Ile Asn Gln 
            500                 505                 510         


Pro Ser Ile Asp Phe Cys Ala Leu Ala Arg Ser Met Gly Val Asp Ala 
        515                 520                 525             


Val Arg Leu Thr Glu Pro Asp Asp Ile Thr Ala Tyr Met Ile Ala Ala 
    530                 535                 540                 


Gly Asp Arg Glu Gly Pro Ser Leu Leu Glu Ile Pro Ile Ala Ala Thr 
545                 550                 555                 560 


Ala Ser 
        


<210>  18
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic enzyme comprising 2-ketoacid decarboxylase activity


<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (538)..(538)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (542)..(542)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Xaa Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Xaa Gly Lys Leu Xaa Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  19
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant of GEO175

<400>  19

Met Arg Thr Val Arg Glu Ser Ala Leu Asp Val Leu Arg Ala Arg Gly 
1               5                   10                  15      


Met Thr Thr Val Phe Gly Asn Pro Gly Ser Thr Glu Leu Pro Met Leu 
            20                  25                  30          


Lys Gln Phe Pro Asp Asp Phe Arg Tyr Val Leu Gly Leu Gln Glu Ala 
        35                  40                  45              


Val Val Val Gly Met Ala Asp Gly Phe Ala Leu Ala Ser Gly Thr Thr 
    50                  55                  60                  


Gly Leu Val Asn Leu His Thr Gly Pro Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  


Ala Ile Leu Asn Ala Arg Ala Asn Arg Thr Pro Met Val Val Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Ala Met Leu Thr Met Glu Ala Leu Leu Thr Asn 
            100                 105                 110         


Pro Gln Ser Thr Leu Leu Pro Gln Pro Ala Val Lys Trp Ala Tyr Glu 
        115                 120                 125             


Pro Pro Arg Ala Ala Asp Val Ala Pro Ala Leu Ala Arg Ala Val Gln 
    130                 135                 140                 


Val Ala Glu Thr Pro Pro Gln Gly Pro Val Phe Val Ser Leu Pro Met 
145                 150                 155                 160 


Asp Asp Phe Asp Val Val Leu Gly Glu Asp Glu Asp Arg Ala Ala Gln 
                165                 170                 175     


Arg Ala Ala Ala Arg Thr Val Thr His Ala Ala Ala Pro Ser Ala Glu 
            180                 185                 190         


Val Val Arg Arg Leu Ala Ala Arg Leu Ser Gly Ala Arg Ser Ala Val 
        195                 200                 205             


Leu Val Ala Gly Asn Asp Val Asp Ala Ser Gly Ala Trp Asp Ala Val 
    210                 215                 220                 


Val Glu Leu Ala Glu Arg Thr Gly Leu Pro Val Trp Ser Ala Pro Ser 
225                 230                 235                 240 


Glu Gly Arg Val Ala Phe Pro Lys Ser His Pro Gln Tyr Arg Gly Met 
                245                 250                 255     


Leu Pro Pro Ala Ile Ala Pro Leu Ser Arg Cys Leu Glu Gly His Asp 
            260                 265                 270         


Leu Val Leu Val Ile Gly Ala Pro Val Phe Cys Tyr Tyr Pro Tyr Val 
        275                 280                 285             


Pro Gly Ala His Leu Pro Glu Asn Thr Glu Leu Val His Leu Thr Arg 
    290                 295                 300                 


Asp Ala Asp Glu Ala Ala Arg Ala Pro Val Gly Asp Ala Val Val Ala 
305                 310                 315                 320 


Asp Leu Ala Leu Thr Val Arg Ala Leu Leu Ala Glu Leu Pro Ala Arg 
                325                 330                 335     


Glu Ala Ala Ala Pro Ala Ala Arg Thr Ala Arg Ala Glu Ser Thr Ala 
            340                 345                 350         


Glu Val Asp Gly Val Leu Thr Pro Leu Ala Ala Met Thr Ala Ile Ala 
        355                 360                 365             


Gln Gly Ala Pro Ala Asn Thr Thr Trp Val Asn Glu Ser Pro Ser Asn 
    370                 375                 380                 


Leu Gly Gln Phe His Asp Ala Thr Arg Ile Asp Thr Pro Gly Ser Phe 
385                 390                 395                 400 


Leu Phe Thr Ala Gly Gly Gly Leu Gly Phe Gly Leu Ala Ala Ala Val 
                405                 410                 415     


Gly Ala Gln Leu Gly Ala Pro Asp Arg Pro Val Val Cys Val Ile Gly 
            420                 425                 430         


Asp Gly Ser Thr His Tyr Ala Val Gln Ala Leu Trp Thr Ala Ala Ala 
        435                 440                 445             


Tyr Lys Val Pro Val Thr Phe Val Val Leu Ser Asn Gln Arg Tyr Ala 
    450                 455                 460                 


Ile Leu Gln Trp Phe Ala Gln Val Glu Gly Ala Gln Gly Ala Pro Gly 
465                 470                 475                 480 


Leu Asp Ile Pro Gly Leu Asp Ile Ala Ala Val Ala Thr Gly Tyr Gly 
                485                 490                 495     


Val Arg Ala His Arg Ala Thr Gly Phe Gly Glu Leu Ser Lys Leu Val 
            500                 505                 510         


Arg Glu Ser Ala Leu Gln Gln Asp Gly Pro Val Leu Ile Asp Val Pro 
        515                 520                 525             


Val Thr Thr Glu Leu Pro Thr Leu 
    530                 535     


<210>  20
<211>  542
<212>  PRT
<213>  Pseudomonas putida

<400>  20

Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      


Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              


Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  


Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  


Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      


Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Leu Leu Thr Asn 
            100                 105                 110         


Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             


Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 


Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     


Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         


Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             


Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 


Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     


Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         


Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             


Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 


Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 


Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     


Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         


Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             


Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 


Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     


Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             


Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 


Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     


Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         


Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             


Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
    530                 535                 540         


<210>  21
<211>  572
<212>  PRT
<213>  Acetobacter pasteurianus

<400>  21

Met Thr Tyr Thr Val Gly Met Tyr Leu Ala Glu Arg Leu Val Gln Ile 
1               5                   10                  15      


Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu 
            20                  25                  30          


Leu Asp Gln Leu Leu Leu Asn Lys Asp Met Lys Gln Ile Tyr Cys Cys 
        35                  40                  45              


Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ser Asn 
    50                  55                  60                  


Gly Ala Ala Ala Ala Val Val Thr Phe Ser Val Gly Ala Ile Ser Ala 
65                  70                  75                  80  


Met Asn Ala Leu Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu 
                85                  90                  95      


Ile Ser Gly Ala Pro Asn Ser Asn Asp Gln Gly Thr Gly His Ile Leu 
            100                 105                 110         


His His Thr Ile Gly Lys Thr Asp Tyr Ser Tyr Gln Leu Glu Met Ala 
        115                 120                 125             


Arg Gln Val Thr Cys Ala Ala Glu Ser Ile Thr Asp Ala His Ser Ala 
    130                 135                 140                 


Pro Ala Lys Ile Asp His Val Ile Arg Thr Ala Leu Arg Glu Arg Lys 
145                 150                 155                 160 


Pro Ala Tyr Leu Asp Ile Ala Cys Asn Ile Ala Ser Glu Pro Cys Val 
                165                 170                 175     


Arg Pro Gly Pro Val Ser Ser Leu Leu Ser Glu Pro Glu Ile Asp His 
            180                 185                 190         


Thr Ser Leu Lys Ala Ala Val Asp Ala Thr Val Ala Leu Leu Glu Lys 
        195                 200                 205             


Ser Ala Ser Pro Val Met Leu Leu Gly Ser Lys Leu Arg Ala Ala Asn 
    210                 215                 220                 


Ala Leu Ala Ala Thr Glu Thr Leu Ala Asp Lys Leu Gln Cys Ala Val 
225                 230                 235                 240 


Thr Ile Met Ala Ala Ala Lys Gly Phe Phe Pro Glu Asp His Ala Gly 
                245                 250                 255     


Phe Arg Gly Leu Tyr Trp Gly Glu Val Ser Asn Pro Gly Val Gln Glu 
            260                 265                 270         


Leu Val Glu Thr Ser Asp Ala Leu Leu Cys Ile Ala Pro Val Phe Asn 
        275                 280                 285             


Asp Tyr Ser Thr Val Gly Trp Ser Ala Trp Pro Lys Gly Pro Asn Val 
    290                 295                 300                 


Ile Leu Ala Glu Pro Asp Arg Val Thr Val Asp Gly Arg Ala Tyr Asp 
305                 310                 315                 320 


Gly Phe Thr Leu Arg Ala Phe Leu Gln Ala Leu Ala Glu Lys Ala Pro 
                325                 330                 335     


Ala Arg Pro Ala Ser Ala Gln Lys Ser Ser Val Pro Thr Cys Ser Leu 
            340                 345                 350         


Thr Ala Thr Ser Asp Glu Ala Gly Leu Thr Asn Asp Glu Ile Val Arg 
        355                 360                 365             


His Ile Asn Ala Leu Leu Thr Ser Asn Thr Thr Leu Val Ala Glu Thr 
    370                 375                 380                 


Gly Asp Ser Trp Phe Asn Ala Met Arg Met Thr Leu Pro Arg Gly Ala 
385                 390                 395                 400 


Arg Val Glu Leu Glu Met Gln Trp Gly His Ile Gly Trp Ser Val Pro 
                405                 410                 415     


Ser Ala Phe Gly Asn Ala Met Gly Ser Gln Asp Arg Gln His Val Val 
            420                 425                 430         


Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln Glu Val Ala Gln 
        435                 440                 445             


Met Val Arg Tyr Glu Leu Pro Val Ile Ile Phe Leu Ile Asn Asn Arg 
    450                 455                 460                 


Gly Tyr Val Ile Glu Ile Ala Ile His Asp Gly Pro Tyr Asn Tyr Ile 
465                 470                 475                 480 


Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe Asn Ala Gly Glu 
                485                 490                 495     


Gly His Gly Leu Gly Leu Lys Ala Thr Thr Pro Lys Glu Leu Thr Glu 
            500                 505                 510         


Ala Ile Ala Arg Ala Lys Ala Asn Thr Arg Gly Pro Thr Leu Ile Glu 
        515                 520                 525             


Cys Gln Ile Asp Arg Thr Asp Cys Thr Asp Met Leu Val Gln Trp Gly 
    530                 535                 540                 


Arg Lys Val Ala Ser Thr Asn Ala Arg Lys Thr Thr Leu Ala Gly Ser 
545                 550                 555                 560 


Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
                565                 570         


<210>  22
<211>  582
<212>  PRT
<213>  Zymomonas mobilis

<400>  22

Met Ser Tyr Thr Val Gly Thr Tyr Leu Ala Glu Arg Leu Val Gln Ile 
1               5                   10                  15      


Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu 
            20                  25                  30          


Leu Asp Asn Leu Leu Leu Asn Lys Asn Met Glu Gln Val Tyr Cys Cys 
        35                  40                  45              


Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ala Lys 
    50                  55                  60                  


Gly Ala Ala Ala Ala Val Val Thr Tyr Ser Val Gly Ala Leu Ser Ala 
65                  70                  75                  80  


Phe Asp Ala Ile Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu 
                85                  90                  95      


Ile Ser Gly Ala Pro Asn Asn Asn Asp His Ala Ala Gly His Val Leu 
            100                 105                 110         


His His Ala Leu Gly Lys Thr Asp Tyr His Tyr Gln Leu Glu Met Ala 
        115                 120                 125             


Lys Asn Ile Thr Ala Ala Ala Glu Ala Ile Tyr Thr Pro Glu Glu Ala 
    130                 135                 140                 


Pro Ala Lys Ile Asp His Val Ile Lys Thr Ala Leu Arg Glu Lys Lys 
145                 150                 155                 160 


Pro Val Tyr Leu Glu Ile Ala Cys Asn Ile Ala Ser Met Pro Cys Ala 
                165                 170                 175     


Ala Pro Gly Pro Ala Ser Ala Leu Phe Asn Asp Glu Ala Ser Asp Glu 
            180                 185                 190         


Ala Ser Leu Asn Ala Ala Val Asp Glu Thr Leu Lys Phe Ile Ala Asn 
        195                 200                 205             


Arg Asp Lys Val Ala Val Leu Val Gly Ser Lys Leu Arg Ala Ala Gly 
    210                 215                 220                 


Ala Glu Glu Ala Ala Val Lys Phe Thr Asp Ala Leu Gly Gly Ala Val 
225                 230                 235                 240 


Ala Thr Met Ala Ala Ala Lys Ser Phe Phe Pro Glu Glu Asn Ala Leu 
                245                 250                 255     


Tyr Ile Gly Thr Ser Trp Gly Glu Val Ser Tyr Pro Gly Val Glu Lys 
            260                 265                 270         


Thr Met Lys Glu Ala Asp Ala Val Ile Ala Leu Ala Pro Val Phe Asn 
        275                 280                 285             


Asp Tyr Ser Thr Thr Gly Trp Thr Asp Ile Pro Asp Pro Lys Lys Leu 
    290                 295                 300                 


Val Leu Ala Glu Pro Arg Ser Val Val Val Asn Gly Ile Arg Phe Pro 
305                 310                 315                 320 


Ser Val His Leu Lys Asp Tyr Leu Thr Arg Leu Ala Gln Lys Val Ser 
                325                 330                 335     


Lys Lys Thr Gly Ser Leu Asp Phe Phe Lys Ser Leu Asn Ala Gly Glu 
            340                 345                 350         


Leu Lys Lys Ala Ala Pro Ala Asp Pro Ser Ala Pro Leu Val Asn Ala 
        355                 360                 365             


Glu Ile Ala Arg Gln Val Glu Ala Leu Leu Thr Pro Asn Thr Thr Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Asp Ser Trp Phe Asn Ala Gln Arg Met Lys Leu 
385                 390                 395                 400 


Pro Asn Gly Ala Arg Val Glu Tyr Glu Met Gln Trp Gly His Ile Gly 
                405                 410                 415     


Trp Ser Val Pro Ala Ala Phe Gly Tyr Ala Val Gly Ala Pro Glu Arg 
            420                 425                 430         


Arg Asn Ile Leu Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln 
        435                 440                 445             


Glu Val Ala Gln Met Val Arg Leu Lys Leu Pro Val Ile Ile Phe Leu 
    450                 455                 460                 


Ile Asn Asn Tyr Gly Tyr Thr Ile Glu Val Met Ile His Asp Gly Pro 
465                 470                 475                 480 


Tyr Asn Asn Ile Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe 
                485                 490                 495     


Asn Gly Asn Gly Gly Tyr Asp Ser Gly Ala Ala Lys Gly Leu Lys Ala 
            500                 505                 510         


Lys Thr Gly Gly Glu Leu Ala Glu Ala Ile Lys Val Ala Leu Ala Asn 
        515                 520                 525             


Thr Asp Gly Pro Thr Leu Ile Glu Cys Phe Ile Gly Arg Glu Asp Cys 
    530                 535                 540                 


Thr Glu Glu Leu Val Lys Trp Gly Lys Arg Val Ala Ala Ala Asn Ser 
545                 550                 555                 560 


Arg Lys Pro Val Asn Lys Val Val Gly Ser Thr Glu Asn Leu Tyr Phe 
                565                 570                 575     


Gln Ser Gly Ala Leu Glu 
            580         


<210>  23
<211>  591
<212>  PRT
<213>  Rheinheimera sp. A13L

<400>  23

Met Ser Ser Ile Asn Ser Phe Thr Val Ala Asp Tyr Leu Leu Thr Arg 
1               5                   10                  15      


Leu His Gln Leu Gly Leu Arg Lys Val Phe Gln Val Pro Gly Asp Tyr 
            20                  25                  30          


Val Ala Asn Phe Met Asp Ala Leu Glu Gln Phe Asn Gly Ile Glu Ala 
        35                  40                  45              


Val Gly Asp Leu Thr Glu Leu Gly Ala Gly Tyr Ala Ala Asp Gly Tyr 
    50                  55                  60                  


Ala Arg Leu Thr Gly Ile Gly Ala Val Ser Val Gln Phe Gly Val Gly 
65                  70                  75                  80  


Thr Phe Ser Val Leu Asn Ala Ile Ala Gly Ser Tyr Val Glu Arg Asn 
                85                  90                  95      


Pro Val Val Val Ile Thr Ala Ser Pro Ser Thr Gly Asn Arg Lys Thr 
            100                 105                 110         


Ile Lys Glu Thr Gly Val Leu Phe His His Ser Thr Gly Asp Leu Leu 
        115                 120                 125             


Ala Asp Ser Lys Val Phe Ala Asn Val Thr Val Ala Ala Glu Val Leu 
    130                 135                 140                 


Ser Asp Pro Ser Asp Ala Arg Gln Lys Ile Asp Lys Ala Leu Thr Leu 
145                 150                 155                 160 


Ala Ile Thr Phe Arg Arg Pro Ile Tyr Leu Glu Ala Trp Gln Asp Val 
                165                 170                 175     


Trp Gly Leu Ala Cys Glu Lys Pro Glu Gly Glu Leu Lys Ala Leu Pro 
            180                 185                 190         


Leu Ile Ser Glu Glu Gly Ala Leu Lys Ala Met Leu Ala Asp Ser Leu 
        195                 200                 205             


Lys Leu Leu Asn Ser Ala Arg Gln Pro Leu Val Leu Leu Gly Val Glu 
    210                 215                 220                 


Ile Asn Arg Phe Gly Leu Gln Asp Ala Val Leu Asp Leu Leu Lys Ala 
225                 230                 235                 240 


Ser Gly Leu Pro Tyr Ser Thr Thr Ser Leu Ala Lys Thr Val Ile Ser 
                245                 250                 255     


Glu Asn Glu Gly Ile Phe Val Gly Thr Tyr Ala Asp Gly Ala Ser Phe 
            260                 265                 270         


Pro Ala Thr Val Glu Tyr Ile Glu Lys Ala Asp Cys Val Leu Ala Leu 
        275                 280                 285             


Gly Val Ile Phe Thr Asp Asp Tyr Leu Thr Met Leu Ser Lys Gln Phe 
    290                 295                 300                 


Asp Gln Met Ile Val Val Asn Asn Asp Glu Thr Ser Arg Leu Gly His 
305                 310                 315                 320 


Ala Tyr Tyr His Gln Leu Tyr Leu Ala Asp Phe Ile Leu Gln Leu Thr 
                325                 330                 335     


Asp Glu Ile Lys Lys Ser Ser Leu Tyr Pro Arg Gln Asn Ser Ala Leu 
            340                 345                 350         


Pro Leu Leu Pro Pro Gln Pro Gln Ile Thr Pro Ala Leu Leu Gln Gln 
        355                 360                 365             


Gln Leu Ser Tyr Gln Asn Phe Phe Asp Leu Phe Tyr Gly Tyr Leu Leu 
    370                 375                 380                 


Gln His Gln Leu Gln Asp Asn Ile Ser Leu Ile Leu Gly Glu Ser Ser 
385                 390                 395                 400 


Ser Leu Tyr Met Ser Ala Arg Leu Tyr Gly Leu Pro Gln Asp Ser Phe 
                405                 410                 415     


Ile Ala Asp Ala Ala Trp Gly Ser Leu Gly His Glu Thr Gly Cys Val 
            420                 425                 430         


Thr Gly Ile Ala Tyr Ala Ser Asp Lys Arg Ala Met Ala Ile Ala Gly 
        435                 440                 445             


Asp Gly Gly Phe Met Met Met Cys Gln Cys Leu Ser Thr Ile Ser Arg 
    450                 455                 460                 


His Gln Leu Asn Ser Val Val Phe Val Ile Ser Asn Lys Val Tyr Ala 
465                 470                 475                 480 


Ile Glu Gln Ser Phe Val Asp Ile Cys Ala Phe Ala Lys Gly Gly His 
                485                 490                 495     


Phe Ala Pro Phe Asp Leu Leu Pro Thr Trp Asp Tyr Leu Ser Leu Ala 
            500                 505                 510         


Lys Ala Phe Ser Val Glu Gly Tyr Arg Val Gln Asn Gly Glu Glu Leu 
        515                 520                 525             


Leu Gln Ala Leu Glu His Ile Met Thr Gln Lys Asp Lys Pro Ala Leu 
    530                 535                 540                 


Val Glu Val Val Ile Gln Ser Gln Asp Leu Ala Pro Ala Met Ala Gly 
545                 550                 555                 560 


Leu Val Lys Ser Ile Thr Gly His Thr Val Glu Gln Cys Ala Ile Pro 
                565                 570                 575     


Thr Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
            580                 585                 590     


<210>  24
<211>  543
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  24

Met Thr Thr Val His Ala Ala Ala Tyr Glu Leu Leu Arg Ser Asn Arg 
1               5                   10                  15      


Leu Thr Thr Ile Phe Gly Asn Pro Gly Asp Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Asp Ala Met Pro Ala Asp Phe Arg Tyr Ile Leu Gly Leu His Glu Gly 
        35                  40                  45              


Val Val Val Gly Met Ala Asp Gly Phe Ala Gln Ala Ser Gly Gln Ala 
    50                  55                  60                  


Ala Phe Val Asn Leu His Ala Ala Ser Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  


Ala Leu Thr Asn Ala Trp Tyr Ser His Thr Pro Leu Val Ile Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Pro Met Ile Gly Leu Glu Ala Met Leu Ser Asn 
            100                 105                 110         


Val Asp Ala Ala Ser Leu Pro Arg Pro Leu Val Lys Trp Ser Ala Glu 
        115                 120                 125             


Pro Ala Gln Ala Pro Asp Val Pro Arg Ala Leu Ser Gln Ala Ile His 
    130                 135                 140                 


Thr Ala Thr Ser Asp Pro Lys Gly Pro Val Tyr Leu Ser Ile Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Asn Gln Asp Thr Gly Asn Leu Ser Glu His Leu Ser Ser 
                165                 170                 175     


Arg Ser Val Ser Arg Ala Gly Asn Pro Ser Ala Glu Gln Leu Asp Asp 
            180                 185                 190         


Ile Leu Ser Ala Leu Arg Glu Ala Ala Asn Pro Ala Leu Val Phe Gly 
        195                 200                 205             


Pro Asp Val Asp Ala Ala Arg Ala Asn His His Ala Val Arg Leu Ala 
    210                 215                 220                 


Glu Lys Leu Ala Ala Pro Val Trp Ile Ala Pro Ala Ala Pro Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Pro Asn Phe Arg Gly Val Leu Pro Ala Ser 
                245                 250                 255     


Ile Ala Gly Ile Ser Ala Leu Leu Asn Gly His Asp Leu Ile Val Val 
            260                 265                 270         


Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Gln Pro Gly Ser Tyr 
        275                 280                 285             


Leu Pro Glu Asn Ser Arg Leu Ile His Ile Thr Cys Asp Ala Gly Glu 
    290                 295                 300                 


Ala Ala Arg Ala Pro Met Gly Asp Ala Leu Val Ala Asp Ile Gly Gln 
305                 310                 315                 320 


Thr Leu Arg Ala Leu Ala Asp Ile Ile Pro Gln Ser Lys Arg Pro Pro 
                325                 330                 335     


Leu Arg Pro Arg Val Ile Pro Pro Val Pro Asp Ser Gln Asp Asp Leu 
            340                 345                 350         


Leu Ala Pro Asp Ala Val Phe Glu Val Met Asn Glu Val Ala Pro Glu 
        355                 360                 365             


Asp Val Val Tyr Val Asn Glu Ser Val Ser Thr Val Thr Ala Leu Trp 
    370                 375                 380                 


Glu Arg Val Glu Leu Lys His Pro Gly Ser Tyr Tyr Phe Pro Ala Ser 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Gly Met Pro Ala Ala Val Gly Val Gln Leu Ala 
                405                 410                 415     


Asn Asp Arg Arg Arg Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Gly Ile Thr Ala Leu Trp Thr Ala Ala Gln Glu Lys Ile Pro Val 
        435                 440                 445             


Val Phe Ile Ile Leu Asn Asn Gly Thr Tyr Gly Ala Leu Arg Ala Phe 
    450                 455                 460                 


Ala Lys Leu Leu Asn Ala Glu Asn Ala Ala Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Ile Cys Phe Cys Ala Ile Ala Glu Gly Tyr Gly Val Glu Ala His Arg 
                485                 490                 495     


Ile Thr Ser Leu Glu Asn Phe Lys Asp Lys Leu Ser Ala Ala Leu Gln 
            500                 505                 510         


Ser Asp Thr Pro Thr Leu Leu Glu Val Pro Thr Ser Thr Thr Ser Pro 
        515                 520                 525             


Phe Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
    530                 535                 540             


<210>  25
<211>  543
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  25

Met Lys Thr Ile His Ser Ala Ala Tyr Ala Leu Leu Arg Arg His Gly 
1               5                   10                  15      


Met Thr Thr Ile Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Lys Ser Phe Pro Glu Asp Phe Gln Tyr Val Leu Gly Leu His Glu Gly 
        35                  40                  45              


Ala Val Val Gly Met Ala Asp Gly Tyr Ala Leu Ala Ser Gly Lys Pro 
    50                  55                  60                  


Ala Phe Val Asn Leu His Ala Ala Ala Gly Thr Gly Asn Gly Met Gly 
65                  70                  75                  80  


Ala Leu Thr Asn Ser Trp Tyr Ser His Ser Pro Leu Val Ile Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Pro Met Ile Gly Val Glu Ala Met Leu Ala Asn 
            100                 105                 110         


Val Asp Ala Thr Gln Leu Pro Lys Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             


Pro Ala Asn Ala Gln Asp Val Pro Arg Ala Leu Ser Gln Ala Ile His 
    130                 135                 140                 


Tyr Ala Asn Thr Thr Pro Lys Ala Pro Val Tyr Leu Ser Ile Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Asp Gln Pro Ser Gly Pro Gly Val Glu His Leu Ile Glu 
                165                 170                 175     


Arg Asp Val Gln Thr Ala Gly Thr Pro Asp Ala Arg Gln Leu Gln Val 
            180                 185                 190         


Leu Val Gln Gln Val Gln Asp Ala Arg Asn Pro Val Leu Val Leu Gly 
        195                 200                 205             


Pro Asp Val Asp Ala Thr Leu Ser Asn Asp His Ala Val Ala Leu Ala 
    210                 215                 220                 


Asp Lys Leu Arg Met Pro Val Trp Ile Ala Pro Ala Ala Ser Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Pro Ser Phe Arg Gly Val Leu Pro Ala Ala 
                245                 250                 255     


Ile Ala Gly Ile Ser Lys Thr Leu Gln Gly His Asp Leu Ile Ile Val 
            260                 265                 270         


Val Gly Ala Pro Val Phe Arg Tyr Leu Gln Phe Ala Pro Gly Asp Tyr 
        275                 280                 285             


Leu Pro Val Gly Ala Gln Leu Leu His Ile Thr Ser Asp Pro Leu Glu 
    290                 295                 300                 


Ala Thr Arg Ala Pro Met Gly His Ala Leu Val Gly Asp Ile Arg Glu 
305                 310                 315                 320 


Thr Leu Arg Val Leu Ala Glu Glu Val Val Gln Gln Ser Arg Pro Tyr 
                325                 330                 335     


Pro Glu Ala Leu Ala Ala Pro Glu Cys Val Thr Asp Glu Pro His His 
            340                 345                 350         


Leu His Pro Glu Thr Leu Phe Asp Val Leu Asp Ala Val Ala Pro His 
        355                 360                 365             


Asp Ala Ile Tyr Val Lys Glu Ser Thr Ser Thr Val Thr Ala Phe Trp 
    370                 375                 380                 


Gln Arg Met Asn Leu Arg His Pro Gly Ser Tyr Tyr Phe Pro Ala Ala 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Gly Leu Pro Ala Ala Val Gly Val Gln Leu Ala 
                405                 410                 415     


Gln Pro Gln Arg Arg Val Val Ala Leu Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Gly Ile Thr Ala Leu Trp Thr Ala Ala Gln Tyr Arg Ile Pro Val 
        435                 440                 445             


Val Phe Ile Ile Leu Lys Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 


Ala Gly Val Leu Lys Ala Glu Asp Ser Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Leu Asp Phe Cys Ala Ile Ala Lys Gly Tyr Gly Val Lys Ala Val His 
                485                 490                 495     


Thr Asp Thr Arg Asp Ser Phe Glu Ala Ala Leu Arg Thr Ala Leu Asp 
            500                 505                 510         


Ala Asn Glu Pro Thr Val Ile Glu Val Pro Thr Leu Thr Ile Gln Pro 
        515                 520                 525             


His Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
    530                 535                 540             


<210>  26
<211>  566
<212>  PRT
<213>  Enterobacter cloacae

<400>  26

Met Arg Thr Pro Tyr Cys Val Ala Asp Tyr Leu Leu Asp Arg Leu Thr 
1               5                   10                  15      


Asp Cys Gly Ala Asp His Leu Phe Gly Val Pro Gly Asp Tyr Asn Leu 
            20                  25                  30          


Gln Phe Leu Asp His Val Ile Asp Ser Pro Asp Ile Cys Trp Val Gly 
        35                  40                  45              


Cys Ala Asn Glu Leu Asn Ala Ser Tyr Ala Ala Asp Gly Tyr Ala Arg 
    50                  55                  60                  


Cys Lys Gly Phe Ala Ala Leu Leu Thr Thr Phe Gly Val Gly Glu Leu 
65                  70                  75                  80  


Ser Ala Met Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Pro Val 
                85                  90                  95      


Leu His Ile Val Gly Ala Pro Gly Thr Ala Ala Gln Gln Arg Gly Glu 
            100                 105                 110         


Leu Leu His His Thr Leu Gly Asp Gly Glu Phe Arg His Phe Tyr His 
        115                 120                 125             


Met Ser Glu Pro Ile Thr Val Ala Gln Ala Val Leu Thr Glu Gln Asn 
    130                 135                 140                 


Ala Cys Tyr Glu Ile Asp Arg Val Leu Thr Thr Met Leu Arg Glu Arg 
145                 150                 155                 160 


Arg Pro Gly Tyr Leu Met Leu Pro Ala Asp Val Ala Lys Lys Ala Ala 
                165                 170                 175     


Thr Pro Pro Val Asn Ala Leu Thr His Lys Gln Ala His Ala Asp Ser 
            180                 185                 190         


Ala Cys Leu Lys Ala Phe Arg Asp Ala Ala Glu Asn Lys Leu Ala Met 
        195                 200                 205             


Ser Lys Arg Thr Ala Leu Leu Ala Asp Phe Leu Val Leu Arg His Gly 
    210                 215                 220                 


Leu Lys His Ala Leu Gln Lys Trp Val Lys Glu Val Pro Met Ala His 
225                 230                 235                 240 


Ala Thr Met Leu Met Gly Lys Gly Ile Phe Asp Glu Arg Gln Ala Gly 
                245                 250                 255     


Phe Tyr Gly Thr Tyr Ser Gly Ser Ala Ser Thr Gly Ala Val Lys Glu 
            260                 265                 270         


Ala Ile Glu Gly Ala Asp Thr Val Leu Cys Val Gly Thr Arg Phe Thr 
        275                 280                 285             


Asp Thr Leu Thr Ala Gly Phe Thr His Gln Leu Thr Pro Ala Gln Thr 
    290                 295                 300                 


Ile Glu Val Gln Pro His Ala Ala Arg Val Gly Asp Val Trp Phe Thr 
305                 310                 315                 320 


Gly Ile Pro Met Asn Gln Ala Ile Glu Thr Leu Val Glu Leu Cys Lys 
                325                 330                 335     


Gln His Val His Ala Gly Leu Met Ser Ser Ser Ser Gly Ala Ile Pro 
            340                 345                 350         


Phe Pro Gln Pro Asp Gly Ser Leu Thr Gln Glu Asn Phe Trp Arg Thr 
        355                 360                 365             


Leu Gln Thr Phe Ile Arg Pro Gly Asp Ile Ile Leu Ala Asp Gln Gly 
    370                 375                 380                 


Thr Ser Ala Phe Gly Ala Ile Asp Leu Arg Leu Pro Ala Asp Val Asn 
385                 390                 395                 400 


Phe Ile Val Gln Pro Leu Trp Gly Ser Ile Gly Tyr Thr Leu Ala Ala 
                405                 410                 415     


Ala Phe Gly Ala Gln Thr Ala Cys Pro Asn Arg Arg Val Ile Val Leu 
            420                 425                 430         


Thr Gly Asp Gly Ala Ala Gln Leu Thr Ile Gln Glu Leu Gly Ser Met 
        435                 440                 445             


Leu Arg Asp Lys Gln His Pro Ile Ile Leu Val Leu Asn Asn Glu Gly 
    450                 455                 460                 


Tyr Thr Val Glu Arg Ala Ile His Gly Ala Glu Gln Arg Tyr Asn Asp 
465                 470                 475                 480 


Ile Ala Leu Trp Asn Trp Thr His Ile Pro Gln Ala Leu Ser Leu Asp 
                485                 490                 495     


Pro Gln Ser Glu Cys Trp Arg Val Ser Glu Ala Glu Gln Leu Ala Asp 
            500                 505                 510         


Val Leu Glu Lys Val Ala His His Glu Arg Leu Ser Leu Ile Glu Val 
        515                 520                 525             


Met Leu Pro Lys Ala Asp Ile Pro Pro Leu Leu Gly Ala Leu Thr Lys 
    530                 535                 540                 


Ala Leu Glu Ala Cys Asn Asn Ala Gly Ser Thr Glu Asn Leu Tyr Phe 
545                 550                 555                 560 


Gln Ser Gly Ala Leu Glu 
                565     


<210>  27
<211>  531
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  27

Met Gly Ala His Tyr Pro Met Ser Gly Glu Ser Thr Val His Asp Val 
1               5                   10                  15      


Thr Tyr Gln Leu Leu Arg Ser Leu Gly Ile Thr Thr Val Phe Gly Asn 
            20                  25                  30          


Pro Gly Ser Thr Glu Gln Thr Phe Leu Gln Asp Phe Pro Ser Asp Phe 
        35                  40                  45              


Thr Tyr Val Leu Gly Leu Gln Glu Ala Ser Val Met Ala Met Ala Asp 
    50                  55                  60                  


Ala Phe Ala Gln Val Thr Arg Arg Pro Ala Leu Val Asn Leu His Ser 
65                  70                  75                  80  


Ser Ala Gly Val Gly His Ser Ile Gly Asn Leu Val Ser Ala Phe Asp 
                85                  90                  95      


Ala His Thr Pro Leu Ile Val Thr Ala Gly Gln Gln His Arg Glu Met 
            100                 105                 110         


Val Ile Gly Glu Pro Ala Leu Ser Asn Arg Glu Ala Thr Asn Leu Pro 
        115                 120                 125             


Arg Pro Trp Val Lys Trp Ser Tyr Glu Pro Ala Arg Ala Gln Asp Val 
    130                 135                 140                 


Pro Glu Ala Phe Met Arg Ala Cys Ala Ile Ala Thr Gln Pro Pro Ala 
145                 150                 155                 160 


Gly Pro Val Phe Leu Ser Ile Pro Leu Asp Asp Trp Asn Ala Pro Met 
                165                 170                 175     


Thr Gly Pro Ala Val Val Arg Ser Val Ser Thr Val Cys Ala Pro Glu 
            180                 185                 190         


Thr Glu Arg Leu Arg Gly Phe Ala Arg Arg Ile Arg Ala Ser Gln Arg 
        195                 200                 205             


Pro Val Leu Val Phe Gly Pro Glu Val Asp Arg Ser Gly Gly Trp His 
    210                 215                 220                 


Ala Ala Ile Ala Leu Ala Glu Asn Leu Gly Val Pro Val Phe Gly Ala 
225                 230                 235                 240 


Ala Gly Pro Asp Arg Val Ser Phe Pro Glu Asp His Pro Leu Phe Gln 
                245                 250                 255     


Gly Arg Leu Gly Met Ser Gln Lys Ser Val Ser Asp Arg Leu Thr Gly 
            260                 265                 270         


Tyr Asp Leu Val Val Val Ile Gly Ala Ala Val Phe Arg Tyr Tyr Pro 
        275                 280                 285             


His Val Pro Gly Asp Ile Leu Pro Ala Gly Thr Glu Leu Leu His Ile 
    290                 295                 300                 


Thr Gly Asp Pro Ala Val Ala Gly Ala Ala Arg Val Gly Asp Ser Val 
305                 310                 315                 320 


Leu Gly Asp Ala Arg Leu Ala Ile Glu Leu Leu Thr Glu Leu Leu Asp 
                325                 330                 335     


Ala Glu Ala Ala His Ser Pro Arg Arg Pro Gln His Gln His Pro His 
            340                 345                 350         


Pro Gln Pro Gln His Val Glu His Val Gln His Gln Gln Pro Pro Gln 
        355                 360                 365             


Thr Arg Phe Gln Ala Arg Ala Gln Pro Arg Pro Pro Arg His Ala Pro 
    370                 375                 380                 


Asp Arg Pro Glu Thr Ala Gly Gly Pro Leu Cys Ala Asp Glu Val His 
385                 390                 395                 400 


Ala Val Ile Asn Ala Ser Arg Pro Arg Asn Ala Ala Leu Val Tyr Glu 
                405                 410                 415     


Ser Thr Ser Thr Ile Gly Glu Gln Val Glu Trp Leu Pro Val Ile Glu 
            420                 425                 430         


Pro Ala Ser Phe Phe Ala Asn Ala Ser Gly Gly Leu Gly Trp Ala Val 
        435                 440                 445             


Pro Ala Ala Val Gly Val Ala Leu Gly Asp Arg Asp Arg Gly Val His 
    450                 455                 460                 


Arg Pro Val Ile Gly Ile Ile Gly Asp Gly Ala Phe Gln Tyr Ser Val 
465                 470                 475                 480 


Gln Ala Leu Trp Thr Ala Thr Gln His Ser Leu Pro Ile Val Phe Val 
                485                 490                 495     


Val Leu Arg His Glu Tyr Ser Ile Leu Lys Ser Phe Ala Glu Leu Glu 
            500                 505                 510         


Arg Thr Ala Gly Val Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly 
        515                 520                 525             


Ala Leu Glu 
    530     


<210>  28
<211>  550
<212>  PRT
<213>  Streptomyces sp. C

<400>  28

Met Arg Thr Val Arg Glu Ser Ala Leu Asp Val Leu Arg Ala Arg Gly 
1               5                   10                  15      


Met Thr Thr Val Phe Gly Asn Pro Gly Ser Thr Glu Leu Pro Met Leu 
            20                  25                  30          


Lys Gln Phe Pro Asp Asp Phe Arg Tyr Val Leu Gly Leu Gln Glu Ala 
        35                  40                  45              


Val Val Val Gly Met Ala Asp Gly Phe Ala Leu Ala Ser Gly Thr Thr 
    50                  55                  60                  


Gly Leu Val Asn Leu His Thr Gly Pro Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  


Ala Ile Leu Asn Ala Arg Ala Asn Arg Thr Pro Met Val Val Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Ala Met Leu Thr Met Glu Ala Leu Leu Thr Asn 
            100                 105                 110         


Pro Gln Ser Thr Leu Leu Pro Gln Pro Ala Val Lys Trp Ala Tyr Glu 
        115                 120                 125             


Pro Pro Arg Ala Ala Asp Val Ala Pro Ala Leu Ala Arg Ala Val Gln 
    130                 135                 140                 


Val Ala Glu Thr Pro Pro Gln Gly Pro Val Phe Val Ser Leu Pro Met 
145                 150                 155                 160 


Asp Asp Phe Asp Val Val Leu Gly Glu Asp Glu Asp Arg Ala Ala Gln 
                165                 170                 175     


Arg Ala Ala Ala Arg Thr Val Thr His Ala Ala Ala Pro Ser Ala Glu 
            180                 185                 190         


Val Val Arg Arg Leu Ala Ala Arg Leu Ser Gly Ala Arg Ser Ala Val 
        195                 200                 205             


Leu Val Ala Gly Asn Asp Val Asp Ala Ser Gly Ala Trp Asp Ala Val 
    210                 215                 220                 


Val Glu Leu Ala Glu Arg Thr Gly Leu Pro Val Trp Ser Ala Pro Thr 
225                 230                 235                 240 


Glu Gly Arg Val Ala Phe Pro Lys Ser His Pro Gln Tyr Arg Gly Met 
                245                 250                 255     


Leu Pro Pro Ala Ile Ala Pro Leu Ser Arg Cys Leu Glu Gly His Asp 
            260                 265                 270         


Leu Val Leu Val Ile Gly Ala Pro Val Phe Cys Tyr Tyr Pro Tyr Val 
        275                 280                 285             


Pro Gly Ala His Leu Pro Glu Asn Thr Glu Leu Val His Leu Thr Arg 
    290                 295                 300                 


Asp Ala Asp Glu Ala Ala Arg Ala Pro Val Gly Asp Ala Val Val Ala 
305                 310                 315                 320 


Asp Leu Ala Leu Thr Val Arg Ala Leu Leu Ala Glu Leu Pro Ala Arg 
                325                 330                 335     


Glu Ala Ala Ala Pro Ala Ala Arg Thr Ala Arg Ala Glu Ser Thr Ala 
            340                 345                 350         


Glu Val Asp Gly Val Leu Thr Pro Leu Ala Ala Met Thr Ala Ile Ala 
        355                 360                 365             


Gln Gly Ala Pro Ala Asn Thr Leu Trp Val Asn Glu Ser Pro Ser Asn 
    370                 375                 380                 


Leu Gly Gln Phe His Asp Ala Thr Arg Ile Asp Thr Pro Gly Ser Phe 
385                 390                 395                 400 


Leu Phe Thr Ala Gly Gly Gly Leu Gly Phe Gly Leu Ala Ala Ala Val 
                405                 410                 415     


Gly Ala Gln Leu Gly Ala Pro Asp Arg Pro Val Val Cys Val Ile Gly 
            420                 425                 430         


Asp Gly Ser Thr His Tyr Ala Val Gln Ala Leu Trp Thr Ala Ala Ala 
        435                 440                 445             


Tyr Lys Val Pro Val Thr Phe Val Val Leu Ser Asn Gln Arg Tyr Ala 
    450                 455                 460                 


Ile Leu Gln Trp Phe Ala Gln Val Glu Gly Ala Gln Gly Ala Pro Gly 
465                 470                 475                 480 


Leu Asp Ile Pro Gly Leu Asp Ile Ala Ala Val Ala Thr Gly Tyr Gly 
                485                 490                 495     


Val Arg Ala His Arg Ala Thr Gly Phe Gly Glu Leu Ser Lys Leu Val 
            500                 505                 510         


Arg Glu Ser Ala Leu Gln Gln Asp Gly Pro Val Leu Ile Asp Val Pro 
        515                 520                 525             


Val Thr Thr Glu Leu Pro Thr Leu Gly Ser Thr Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Ser Gly Ala Leu Glu 
545                 550 


<210>  29
<211>  548
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  29

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  30
<211>  542
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  30

Met Lys Thr Val His Gly Ala Thr Tyr Asp Ile Leu Arg Gln His Gly 
1               5                   10                  15      


Leu Thr Thr Ile Phe Gly Asn Pro Gly Asp Asn Glu Leu Pro Phe Leu 
            20                  25                  30          


Lys Gly Phe Pro Glu Asp Phe Arg Tyr Ile Leu Gly Leu His Glu Gly 
        35                  40                  45              


Ala Val Val Gly Met Ala Asp Gly Tyr Ala Leu Ala Ser Gly Gln Pro 
    50                  55                  60                  


Thr Phe Val Asn Leu His Ala Ala Ala Gly Thr Gly Asn Gly Met Gly 
65                  70                  75                  80  


Ala Leu Thr Asn Ala Trp Tyr Ser His Ser Pro Leu Val Ile Thr Ala 
                85                  90                  95      


Gly Gln Gln Val Arg Ser Met Ile Gly Val Glu Ala Met Leu Ala Asn 
            100                 105                 110         


Val Asp Ala Ala Gln Leu Pro Lys Pro Leu Val Lys Trp Ser His Glu 
        115                 120                 125             


Pro Ala Thr Ala Gln Asp Val Pro Arg Ala Leu Ser Gln Ala Ile His 
    130                 135                 140                 


Thr Ala Asn Leu Pro Pro Arg Gly Pro Val Tyr Val Ser Ile Pro Tyr 
145                 150                 155                 160 


Asp Asp Trp Ala Cys Glu Ala Pro Ser Gly Val Glu His Leu Ala Arg 
                165                 170                 175     


Arg Gln Val Ser Ser Ala Gly Leu Pro Ser Pro Ala Gln Leu Gln His 
            180                 185                 190         


Leu Cys Glu Arg Leu Ala Ala Ala Arg Asn Pro Val Leu Val Leu Gly 
        195                 200                 205             


Pro Asp Val Asp Gly Ser Ala Ala Asn Gly Leu Ala Val Gln Leu Ala 
    210                 215                 220                 


Glu Lys Leu Arg Met Pro Ala Trp Val Ala Pro Ser Ala Ser Arg Cys 
225                 230                 235                 240 


Pro Phe Pro Thr Arg His Ala Cys Phe Arg Gly Val Leu Pro Ala Ala 
                245                 250                 255     


Ile Ala Gly Ile Ser His Asn Leu Ala Gly His Asp Leu Ile Leu Val 
            260                 265                 270         


Val Gly Ala Pro Val Phe Arg Tyr His Gln Phe Ala Pro Gly Asn Tyr 
        275                 280                 285             


Leu Pro Ala Gly Cys Glu Leu Leu His Leu Thr Cys Asp Pro Gly Glu 
    290                 295                 300                 


Ala Ala Arg Ala Pro Met Gly Asp Ala Leu Val Gly Asp Ile Ala Leu 
305                 310                 315                 320 


Thr Leu Glu Ala Val Leu Asp Gly Val Pro Gln Ser Val Arg Gln Met 
                325                 330                 335     


Pro Thr Ala Leu Pro Ala Ala Glu Pro Val Ala Asp Asp Gly Gly Leu 
            340                 345                 350         


Leu Arg Pro Glu Thr Val Phe Asp Leu Leu Asn Ala Leu Ala Pro Lys 
        355                 360                 365             


Asp Ala Ile Tyr Val Lys Glu Ser Thr Ser Thr Val Gly Ala Phe Trp 
    370                 375                 380                 


Arg Arg Val Glu Met Arg Glu Pro Gly Ser Tyr Phe Phe Pro Ala Ala 
385                 390                 395                 400 


Gly Gly Leu Gly Phe Gly Leu Pro Ala Ala Val Gly Val Gln Leu Ala 
                405                 410                 415     


Ser Pro Gly Arg Gln Val Ile Gly Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         


Tyr Gly Ile Thr Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Val 
        435                 440                 445             


Val Phe Ile Ile Leu Lys Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 


Ala Asp Val Leu Asp Val Asn Asp Ala Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 


Leu Asp Phe Cys Ala Ile Ala Arg Gly Tyr Gly Val Gln Ala Val His 
                485                 490                 495     


Ala Ala Thr Gly Ser Ala Phe Ala Gln Ala Leu Arg Glu Ala Leu Glu 
            500                 505                 510         


Ser Asp Arg Pro Val Leu Ile Glu Val Pro Thr Gln Thr Ile Glu Pro 
        515                 520                 525             


Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
    530                 535                 540         


<210>  31
<211>  546
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  31

Met Ala Arg Phe Gly Val Arg Lys Ala Phe Gly Val Val Gly Ser Gly 
1               5                   10                  15      


Asn Phe His Phe Thr Asn Gly Leu Ile Gln Gly Gly Ala Glu Phe Val 
            20                  25                  30          


Ala Ala Arg His Glu Gly Gly Ala Thr Thr Met Ala Asp Ala Tyr Ala 
        35                  40                  45              


Arg Cys Ser Gly Glu Val Ala Ala Val Ser Val His Gln Gly Cys Gly 
    50                  55                  60                  


Leu Gly Asn Ala Thr Thr Gly Ile Gly Glu Ala Ala Lys Ser Arg Thr 
65                  70                  75                  80  


Pro Leu Val Val Val Thr Ala Glu Ala Thr Asp Pro Leu Ser Asn Phe 
                85                  90                  95      


His Ile Asp Gln Asp Ala Leu Ala Arg Ser Val Gly Ala Ser Ser Ile 
            100                 105                 110         


Leu Val Arg Ser Ala Lys Thr Ala Leu Ala Asp Val Arg Arg Ala Phe 
        115                 120                 125             


Thr Gln Ala Arg Gln Asp Arg Arg Thr Val Leu Leu Arg Leu Pro Leu 
    130                 135                 140                 


Glu Val Gln Ala Glu Pro Phe Asp Glu Ser Leu Leu Glu Gly Leu Thr 
145                 150                 155                 160 


Ala Ile Glu Ala Leu Pro Gln Pro Arg Ala Ala Glu Ala Glu Val Gln 
                165                 170                 175     


Ala Leu Ala Ser Ile Leu Gln Arg Ala Glu Arg Pro Val Phe Leu Cys 
            180                 185                 190         


Gly Arg Gly Ser Arg Ala Ala Arg Ala Glu Leu Val Ala Leu Ala Asp 
        195                 200                 205             


Arg Cys Gly Ala Leu Leu Ala Glu Gly Ala Val Ala Lys Gly Leu Phe 
    210                 215                 220                 


Ala Gly Glu Pro Trp Ala Ile Gly Val Ser Gly Gly Phe Ser Ser Pro 
225                 230                 235                 240 


Leu Thr Thr Glu Leu Ile Gln Gly Ala Asp Val Val Val Gly Trp Gly 
                245                 250                 255     


Ser Ala Leu Asn Asp Trp Thr Thr Ala His Gly Arg Leu Leu Ser Pro 
            260                 265                 270         


Glu Thr Thr Leu Val Gln Val Asp Leu Glu Ser Ala Ala Leu Gly Arg 
        275                 280                 285             


Asn Arg Pro Val Asp Leu Gly Ile Val Gly Asp Val Gly Gly Thr Ala 
    290                 295                 300                 


Leu Ala Val Ala Glu Leu Leu Glu Val His Asn Gly Tyr Arg Ser Ala 
305                 310                 315                 320 


Glu Leu Lys Thr Arg Ile Ala Arg Glu Ile Arg Trp Arg Asp Asn Glu 
                325                 330                 335     


Tyr Asp Asp Val Ser Thr Gly Glu Val Ile Asp Pro Arg Thr Leu Ser 
            340                 345                 350         


Ala Ala Leu Asp Glu Leu Leu Pro Ala Asn Arg Val Val Gly Val Asp 
        355                 360                 365             


Ser Gly Asn Phe Met Gly Tyr Pro Thr Met Tyr Leu Asp Val Pro Asp 
    370                 375                 380                 


Glu Asn Gly Phe Cys Phe Thr Gln Ala Phe Ala Ser Ile Gly Leu Gly 
385                 390                 395                 400 


Leu Ala Thr Ala Ile Gly Thr Ala Leu Ala Arg Pro Asp Arg Phe Pro 
                405                 410                 415     


Val Ala Ala Cys Gly Asp Gly Gly Phe Leu Met Ser Ile Ala Glu Leu 
            420                 425                 430         


Glu Thr Val Val Arg Leu Lys Leu Pro Met Leu Ile Val Val Tyr Asn 
        435                 440                 445             


Asp His Ala Tyr Gly Ala Glu Val Tyr Phe Phe Glu Pro Gly Gly His 
    450                 455                 460                 


Pro Ala Asp Thr Val Thr Phe Pro Asp Thr Asp Leu Ala Ala Ile Ala 
465                 470                 475                 480 


Arg Gly Tyr Gly Cys Asp Ala Val Thr Val Arg Thr Lys Glu Asp Leu 
                485                 490                 495     


Ala Glu Val Ala Thr Arg Val Ala Ala Gly Leu Asp Arg Pro Leu Val 
            500                 505                 510         


Val Asp Ala Lys Ile Ala Gly Phe Ser Ala Trp Trp Leu Gln Ala Ala 
        515                 520                 525             


Met Thr His His Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser Gly Ala 
    530                 535                 540                 


Leu Glu 
545     


<210>  32
<211>  580
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  32

Met Thr Ser Arg Ser Ser Phe Ser Pro Pro Ser Ala Ser Glu Gln Arg 
1               5                   10                  15      


Gly Ala Asp Ile Phe Ala Glu Val Leu Gln Cys Glu Gly Val Arg Tyr 
            20                  25                  30          


Ile Phe Gly Asn Pro Gly Thr Thr Glu Leu Pro Leu Leu Asp Ala Leu 
        35                  40                  45              


Thr Asp Ile Thr Gly Ile His Tyr Val Leu Gly Leu His Glu Ala Ser 
    50                  55                  60                  


Val Val Ala Met Ala Asp Gly Tyr Ala Gln Ala Ser Gly Lys Pro Gly 
65                  70                  75                  80  


Phe Val Asn Leu His Thr Ala Gly Gly Leu Gly Asn Ala Met Gly Ala 
                85                  90                  95      


Ile Leu Asn Ala Lys Met Ala Asn Thr Pro Leu Val Val Thr Ala Gly 
            100                 105                 110         


Gln Gln Asp Thr Arg His Gly Val Thr Asp Pro Leu Leu His Gly Asp 
        115                 120                 125             


Leu Thr Gly Ile Ala Arg Pro Asn Val Lys Trp Ala Glu Glu Ile His 
    130                 135                 140                 


His Pro Glu His Ile Pro Met Leu Leu Arg Arg Ala Leu Gln Asp Cys 
145                 150                 155                 160 


Arg Thr Gly Pro Ala Gly Pro Val Phe Leu Ser Leu Pro Ile Asp Thr 
                165                 170                 175     


Met Glu Arg Cys Thr Ser Val Gly Ala Gly Glu Ala Ser Arg Ile Glu 
            180                 185                 190         


Arg Ala Ser Val Ala Asn Met Leu His Ala Leu Ala Thr Ala Leu Ala 
        195                 200                 205             


Glu Val Thr Ala Gly His Ile Ala Leu Val Ala Gly Glu Glu Val Phe 
    210                 215                 220                 


Thr Ala Asn Ala Ser Val Glu Ala Val Ala Leu Ala Glu Ala Leu Gly 
225                 230                 235                 240 


Ala Pro Val Phe Gly Ala Ser Trp Pro Gly His Ile Pro Phe Pro Thr 
                245                 250                 255     


Ala His Pro Gln Trp Gln Gly Thr Leu Pro Pro Lys Ala Ser Asp Ile 
            260                 265                 270         


Arg Glu Thr Leu Gly Pro Phe Asp Ala Val Leu Ile Leu Gly Gly His 
        275                 280                 285             


Ser Leu Ile Ser Tyr Pro Tyr Ser Glu Gly Pro Ala Ile Pro Pro His 
    290                 295                 300                 


Cys Arg Leu Phe Gln Leu Thr Gly Asp Gly His Gln Ile Gly Arg Val 
305                 310                 315                 320 


His Glu Thr Thr Leu Gly Leu Val Gly Asp Leu Gln Leu Ser Leu Arg 
                325                 330                 335     


Ala Leu Leu Pro Leu Leu Ala Arg Lys Leu Gln Pro Gln Asn Gly Ala 
            340                 345                 350         


Val Ala Arg Leu Arg Gln Val Ala Thr Leu Lys Arg Asp Ala Arg Arg 
        355                 360                 365             


Thr Glu Ala Ala Glu Arg Ser Ala Arg Glu Phe Asp Ala Ser Ala Thr 
    370                 375                 380                 


Thr Pro Phe Val Ala Ala Phe Glu Thr Ile Arg Ala Ile Gly Pro Asp 
385                 390                 395                 400 


Val Pro Ile Val Asp Glu Ala Pro Val Thr Ile Pro His Val Arg Ala 
                405                 410                 415     


Cys Leu Asp Ser Ala Ser Ala Arg Gln Tyr Leu Phe Thr Arg Ser Ala 
            420                 425                 430         


Ile Leu Gly Trp Gly Met Pro Ala Ala Val Gly Val Ser Leu Gly Leu 
        435                 440                 445             


Asp Arg Ser Pro Val Val Cys Leu Val Gly Asp Gly Ser Ala Met Tyr 
    450                 455                 460                 


Ser Pro Gln Ala Leu Trp Thr Ala Ala His Glu Arg Leu Pro Val Thr 
465                 470                 475                 480 


Phe Val Val Phe Asn Asn Gly Glu Tyr Asn Ala Leu Lys Asn Phe Ala 
                485                 490                 495     


Arg Ala Gln Thr Asn Tyr Arg Ser Ala Arg Ala Asn Arg Phe Ile Gly 
            500                 505                 510         


Leu Asp Ile Ser Asp Pro Ala Ile Asp Phe Pro Ala Leu Ala Ser Ser 
        515                 520                 525             


Leu Gly Val Pro Ala Arg Arg Val Glu Arg Ala Gly Asp Ile Ala Ile 
    530                 535                 540                 


Ala Val Glu Asp Gly Ile Arg Ser Gly Arg Pro Asn Leu Ile Asp Val 
545                 550                 555                 560 


Leu Ile Ser Ser Ser Ser Gly Ser Thr Glu Asn Leu Tyr Phe Gln Ser 
                565                 570                 575     


Gly Ala Leu Glu 
            580 


<210>  33
<211>  552
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  33

Met Leu Arg Thr Ala Gly Glu Glu Ser Gly Val Lys Val Arg Asp Ala 
1               5                   10                  15      


Phe Phe Glu Val Leu Arg Ser His Gly Ile Thr Thr Val Phe Gly Asn 
            20                  25                  30          


Pro Gly Ser Asn Glu Leu Pro Leu Leu Arg Asp Phe Pro Asp Asp Phe 
        35                  40                  45              


Arg Tyr Val Leu Ala Leu His Glu Gly Ala Ala Ile Ala Met Ala Asp 
    50                  55                  60                  


Gly Tyr Ala Leu Ala Thr Gly Arg Pro Ser Leu Val Asn Leu His Ala 
65                  70                  75                  80  


Ala Ala Gly Thr Gly Asn Ala Met Gly Asn Leu Thr Asn Thr Gln Ser 
                85                  90                  95      


Gly His Val Pro Val Val Val Thr Ser Gly Gln Gln Ala Arg Arg Tyr 
            100                 105                 110         


Thr Ala Leu Asn Ala Leu Leu Thr Asn Val Asp Ala Thr Ala Leu Ala 
        115                 120                 125             


Glu Pro Leu Val Lys Trp Ser Cys Glu Pro Leu Arg Pro Glu Asp Val 
    130                 135                 140                 


Pro Gln Ala Leu Ser Gln Gly Ile Leu Leu Ala Gly Ser Ala Pro Ala 
145                 150                 155                 160 


Gly Pro Val Tyr Leu Ser Leu Pro Leu Asp Asp Trp Asp His Gln Ala 
                165                 170                 175     


Asp Pro Gly Ala Leu Lys His Leu Lys Ala Arg Thr Val Gln Gly Asp 
            180                 185                 190         


Pro Val Val Ser Glu Pro Ala Leu Asp Leu Leu Arg Arg Arg Leu Thr 
        195                 200                 205             


Gly Ala Ala Asn Pro Val Met Val Val Gly Pro Gly Ile Asp Asp Ala 
    210                 215                 220                 


Thr Gly Trp Asp Gly Ala Cys Arg Leu Ala Asp Arg Leu Ala Leu Pro 
225                 230                 235                 240 


Val Phe Val Ala Pro Ser Pro Ser Arg Cys Pro Phe Pro Thr Arg His 
                245                 250                 255     


Pro Gly Tyr Arg Gly Val Leu Pro Ser Asp Ile Pro Ala Val Ala Arg 
            260                 265                 270         


His Phe Asp Gly His Asp Leu Val Val Ala Phe Gly Ala Ala Ile Phe 
        275                 280                 285             


Arg Tyr Phe Ala Phe Glu Glu Gly Asp Tyr Leu Pro Pro Gly Thr Glu 
    290                 295                 300                 


Leu Trp Ala Val Thr Ser Asp Pro Asp Glu Ala Thr Arg Ala Pro Phe 
305                 310                 315                 320 


Gly Arg Ile Leu Val Gly Asn Pro Ser Asp Ala Leu Ala Arg Leu Thr 
                325                 330                 335     


Glu Thr Val Pro Ala Arg His Arg Pro Pro Pro Pro Pro Leu Glu Arg 
            340                 345                 350         


Thr Ser Arg Leu Asn Glu Ala Gly Pro Ala Phe Ser Ala Glu Ala Ile 
        355                 360                 365             


Val Asp Ala Leu Asp Ala Ala Lys Asp Glu Ser Thr Val Leu Ala His 
    370                 375                 380                 


Glu Trp Thr Ser Val Leu Thr Thr Trp Asp Arg Phe Asp Ile Ser Arg 
385                 390                 395                 400 


Pro Gly Ser Leu Tyr Phe Pro Ala Ser Gly Gly Leu Gly Trp Gly Leu 
                405                 410                 415     


Pro Ala Ala Ile Gly Leu Gln Leu Gly Asp Pro Ser Arg Arg Val Leu 
            420                 425                 430         


Ala Met Leu Gly Asp Gly Ala Leu His Tyr Thr Val Ser Ala Leu Trp 
        435                 440                 445             


Thr Ala Ala Arg Tyr Arg Val Pro Val Val Phe Val Val Ala Arg Asn 
    450                 455                 460                 


Gly Glu Tyr Gly Ala Leu Lys Lys Phe Thr Gln Ala Met Gln Ala Pro 
465                 470                 475                 480 


Gly Val Pro Gly Leu Glu Leu Pro Gly Ile Asp Ile Thr Gly Ile Ala 
                485                 490                 495     


Ser Ala Tyr Gly Ile Ser Ala Thr Arg Ile Asp Thr Leu Asp Ala Leu 
            500                 505                 510         


Thr Ala Ala Val Thr Ala Ala Leu Ala Thr Asp Glu Pro His Leu Ile 
        515                 520                 525             


Glu Val Pro Gln Gln Pro Leu Thr Ala Ser Gly Ser Thr Glu Asn Leu 
    530                 535                 540                 


Tyr Phe Gln Ser Gly Ala Leu Glu 
545                 550         


<210>  34
<211>  603
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  34

Met Ala Pro Tyr Arg Ala Pro His Arg Ser Pro His Ser Tyr Phe Thr 
1               5                   10                  15      


Met Lys Gly His Glu Ala Ile Leu Arg Gln Phe Leu Ala Asn Gly Met 
            20                  25                  30          


Asp His Met Phe Gly Thr Pro Gly Asp Val Glu Gln Gly Phe Leu Asp 
        35                  40                  45              


Ala Leu Ala Asp Val Pro Glu Met Lys Tyr Ile Leu Thr Leu Gln Glu 
    50                  55                  60                  


Ser Ile Ala Val Leu Cys Ala Asp Gly Tyr Ala Arg Ala Arg Leu Lys 
65                  70                  75                  80  


Pro Ala Leu Val Gln Ile His Ser Ser Pro Gly Leu Gly Asn Ala Ile 
                85                  90                  95      


Gly Asn Leu Tyr Gln Ala Met Arg Gly Gln Ala Pro Leu Val Val Ile 
            100                 105                 110         


Gly Gly Asp Ala Gly Ile Lys Tyr Gln Ala Met Asp Ala Gln Met Ala 
        115                 120                 125             


Ala Asp Leu Val Ala Met Ala Glu Pro Val Thr Lys Trp Ser Ala Met 
    130                 135                 140                 


Val Gln His Pro Ser Ser Leu Leu Arg Met Val Arg Arg Ala Ile Lys 
145                 150                 155                 160 


Val Ala Ala Thr Pro Pro Cys Gly Pro Val Tyr Leu Cys Leu Pro Glu 
                165                 170                 175     


Asp Ile Leu Asp Ala Glu Ile Thr Glu Lys Ile Ile Pro Ala His Ile 
            180                 185                 190         


Pro Ser Leu Glu Thr Cys Pro Gly Ser Leu Asp Leu Asp Arg Met Val 
        195                 200                 205             


Ser Ala Ile Gln Ser Ala Gln Asn Pro Ile Ile Leu Val Gly Asp Gly 
    210                 215                 220                 


Val Ala Trp Thr Gly Gly Val Glu Lys Ile Val Asp Leu Ala Glu Thr 
225                 230                 235                 240 


Leu Gly Ala Lys Val Tyr Ser Ala Asp Gly Gly Glu Ile Asn Phe Pro 
                245                 250                 255     


Asp Asp His Leu Leu Asn Tyr Gly Ser Thr Gly Ala Met Phe Gly Asp 
            260                 265                 270         


Gln Ser Leu Pro Ile Met Gln Ser Cys Asp Leu Cys Leu Thr Leu Gly 
        275                 280                 285             


Cys Tyr Leu Leu Pro Glu Val Phe Pro His Leu Gly Asp Ile Phe Asn 
    290                 295                 300                 


Glu Asp Ala Thr Ile Ile His Val Asp Thr Asn Val Asp Asn Ile Ala 
305                 310                 315                 320 


Lys Asn His Arg Val Asp Ile Ser Tyr Val Ala Glu Pro His Ser Val 
                325                 330                 335     


Val Thr Gly Leu Leu Pro Ile Leu Lys Ser Leu Ser Ser Ser Trp His 
            340                 345                 350         


Asn Ala Ala Gln Gln Arg Arg Ser Lys Leu Glu Ser Glu Ser Pro Val 
        355                 360                 365             


Val His Asn Asn Val Asp Gln Asn Tyr Gln Val Glu Pro Pro Tyr Pro 
    370                 375                 380                 


Ser Glu Ala Tyr Asp Gly Ile Asn Arg Ser Met Arg Ser Gly Tyr Phe 
385                 390                 395                 400 


Ile Lys Thr Leu Ala Asp Lys Leu Pro Lys Glu Thr Ile Ile Phe Asp 
                405                 410                 415     


Glu Ala Leu Thr Asn Ser Pro Pro Val Asn Arg Tyr Leu Pro Gly Gln 
            420                 425                 430         


Lys Pro Gly Asp Arg Met Leu Thr Arg Gly Gly Ser Leu Gly Thr Gly 
        435                 440                 445             


Phe Pro Gly Ala Ile Gly Ala Lys Ile Ala Tyr Pro Asp Arg Cys Val 
    450                 455                 460                 


Ile Gly Phe Ser Gly Asp Gly Gly Ser Met Tyr Thr Ile Gln Cys Leu 
465                 470                 475                 480 


Trp Thr Ala Val Arg His Asn Val Ala Ala Lys Phe Ile Val Cys Gln 
                485                 490                 495     


Asn Arg Ser Tyr Lys Leu Leu Gln Ser Asn Ile Ser Lys Phe Trp Gln 
            500                 505                 510         


Glu Arg Gly Ile Glu Gly Arg Glu Phe Pro Val Pro Phe Asp Leu Ser 
        515                 520                 525             


Lys Pro Glu Ile Cys Phe Ser Val Ile Ala Asn Ser Phe Gly Val Ser 
    530                 535                 540                 


Gly Glu Arg Val Val Arg Pro Asp Gln Val Gly Glu Ala Ile Asp Arg 
545                 550                 555                 560 


Met Leu Asn His Asp Gly Pro Tyr Leu Ile Asn Leu Val Leu Asp Gly 
                565                 570                 575     


Asp Ile Arg Pro Asp Leu Ile Gly Val Arg Cys Gly Gln Gly Ser Thr 
            580                 585                 590         


Glu Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu 
        595                 600             


<210>  35
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutants of KIVD


<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  Xaa is Ala, Asp, Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (286)..(286)
<223>  Xaa is Phe, Met, Ser, Thr, Trp or Tyr

<400>  35

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Xaa Xaa Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  36
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutants of KIVD


<220>
<221>  MISC_FEATURE
<222>  (377)..(377)
<223>  Xaa is Ala, Phe, Met, Trp, Gln, Ile, Leu or Arg

<220>
<221>  MISC_FEATURE
<222>  (381)..(381)
<223>  Xaa is Ala, Leu, Phe, Ser, or Val

<220>
<221>  MISC_FEATURE
<222>  (382)..(382)
<223>  Xaa is Ala, Phe, Met, Trp, Ile, or Leu

<400>  36

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Xaa Gly Thr Ser Xaa Xaa Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  37
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutants of KIVD


<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa is Ala, Ile, Leu, Met, Thr, Val, or Ser

<400>  37

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Xaa Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  38
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutants of KIVD


<220>
<221>  MISC_FEATURE
<222>  (461)..(461)
<223>  Xaa is Ala, Met, Trp, Thr, or Val

<220>
<221>  MISC_FEATURE
<222>  (465)..(465)
<223>  Xaa is Ile or Val

<400>  38

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Xaa Glu Arg Glu 
    450                 455                 460                 


Xaa His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  39
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutants of KIVD


<220>
<221>  MISC_FEATURE
<222>  (538)..(538)
<223>  Xaa is Ala, His, Leu, Met, Val, or Thr

<220>
<221>  MISC_FEATURE
<222>  (542)..(542)
<223>  Xaa is Ala, Phe, His, Ile, Met, Thr, Val, Trp, Tyr, or Leu

<400>  39

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Xaa Gly Lys Leu Xaa Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  40
<211>  570
<212>  PRT
<213>  Lactococcus lactis

<400>  40

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Met Tyr Thr Val Gly Asp Tyr Leu Leu 
            20                  25                  30          


Asp Arg Leu His Glu Leu Gly Ile Glu Glu Ile Phe Gly Val Pro Gly 
        35                  40                  45              


Asp Tyr Asn Leu Gln Phe Leu Asp Gln Ile Ile Ser Arg Glu Asp Met 
    50                  55                  60                  


Lys Trp Ile Gly Asn Ala Asn Glu Leu Asn Ala Ser Tyr Met Ala Asp 
65                  70                  75                  80  


Gly Tyr Ala Arg Thr Lys Lys Ala Ala Ala Phe Leu Thr Thr Phe Gly 
                85                  90                  95      


Val Gly Glu Leu Ser Ala Ile Asn Gly Leu Ala Gly Ser Tyr Ala Glu 
            100                 105                 110         


Asn Leu Pro Val Val Glu Ile Val Gly Ser Pro Thr Ser Lys Val Gln 
        115                 120                 125             


Asn Asp Gly Lys Phe Val His His Thr Leu Ala Asp Gly Asp Phe Lys 
    130                 135                 140                 


His Phe Met Lys Met His Glu Pro Val Thr Ala Ala Arg Thr Leu Leu 
145                 150                 155                 160 


Thr Ala Glu Asn Ala Thr Tyr Glu Ile Asp Arg Val Leu Ser Gln Leu 
                165                 170                 175     


Leu Lys Glu Arg Lys Pro Val Tyr Ile Asn Leu Pro Val Asp Val Ala 
            180                 185                 190         


Ala Ala Lys Ala Glu Lys Pro Ala Leu Ser Leu Glu Lys Glu Ser Ser 
        195                 200                 205             


Thr Thr Asn Thr Thr Glu Gln Val Ile Leu Ser Lys Ile Glu Glu Ser 
    210                 215                 220                 


Leu Lys Asn Ala Gln Lys Pro Val Val Ile Ala Gly His Glu Val Ile 
225                 230                 235                 240 


Ser Phe Gly Leu Glu Lys Thr Val Thr Gln Phe Val Ser Glu Thr Lys 
                245                 250                 255     


Leu Pro Ile Thr Thr Leu Asn Phe Gly Lys Ser Ala Val Asp Glu Ser 
            260                 265                 270         


Leu Pro Ser Phe Leu Gly Ile Tyr Asn Gly Lys Leu Ser Glu Ile Ser 
        275                 280                 285             


Leu Lys Asn Phe Val Glu Ser Ala Asp Phe Ile Leu Met Leu Gly Val 
    290                 295                 300                 


Lys Leu Thr Asp Ser Ser Thr Gly Ala Phe Thr His His Leu Asp Glu 
305                 310                 315                 320 


Asn Lys Met Ile Ser Leu Asn Ile Asp Glu Gly Ile Ile Phe Asn Lys 
                325                 330                 335     


Val Val Glu Asp Phe Asp Phe Arg Ala Val Val Ser Ser Leu Ser Glu 
            340                 345                 350         


Leu Lys Gly Ile Glu Tyr Glu Gly Gln Tyr Ile Asp Lys Gln Tyr Glu 
        355                 360                 365             


Glu Phe Ile Pro Ser Ser Ala Pro Leu Ser Gln Asp Arg Leu Trp Gln 
    370                 375                 380                 


Ala Val Glu Ser Leu Thr Gln Ser Asn Glu Thr Ile Val Ala Glu Gln 
385                 390                 395                 400 


Gly Thr Ser Phe Phe Gly Ala Ser Thr Ile Phe Leu Lys Ser Asn Ser 
                405                 410                 415     


Arg Phe Ile Gly Gln Pro Leu Trp Gly Ser Ile Gly Tyr Thr Phe Pro 
            420                 425                 430         


Ala Ala Leu Gly Ser Gln Ile Ala Asp Lys Glu Ser Arg His Leu Leu 
        435                 440                 445             


Phe Ile Gly Asp Gly Ser Leu Gln Leu Thr Val Gln Glu Leu Gly Leu 
    450                 455                 460                 


Ser Ile Arg Glu Lys Leu Asn Pro Ile Cys Phe Ile Ile Asn Asn Asp 
465                 470                 475                 480 


Gly Tyr Thr Val Glu Arg Glu Ile His Gly Pro Thr Gln Ser Tyr Asn 
                485                 490                 495     


Asp Ile Pro Met Trp Asn Tyr Ser Lys Leu Pro Glu Thr Phe Gly Ala 
            500                 505                 510         


Thr Glu Asp Arg Val Val Ser Lys Ile Val Arg Thr Glu Asn Glu Phe 
        515                 520                 525             


Val Ser Val Met Lys Glu Ala Gln Ala Asp Val Asn Arg Met Tyr Trp 
    530                 535                 540                 


Ile Glu Leu Val Leu Glu Lys Glu Asp Ala Pro Lys Leu Leu Lys Lys 
545                 550                 555                 560 


Met Gly Lys Leu Phe Ala Glu Gln Asn Lys 
                565                 570 


