                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       University of Rijeka Faculty of Medicine
 
<120>  ANTIBODIES SPECIFIC TO HUMAN T-CELL IMMUNOGLOBULIN AND ITIM 
       DOMAIN (TIGIT)

<130>  YISSUM/0124 PCT

<150>  62/213140
<151>  2015-09-02

<150>  62/314427
<151>  2016-03-29

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  3

Lys Gly Pro Tyr Tyr Thr Lys Asn Glu Asp Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Ala Ser Glu His Ile Tyr Tyr Ser Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Asn Ala Asn Ser Leu Glu Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Gln Ala Tyr Asp Val Pro Arg Thr 
1               5                   


<210>  7
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Gly Pro Tyr Tyr Thr Lys Asn Glu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ile Leu Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Tyr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  


Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser 
        115     


<210>  9
<211>  360
<212>  DNA
<213>  Mus Musculus

<400>  9
caggtgcagc tgcaggagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca agctatggta taagctgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatccca gaagtggtaa tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggagctca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaaaggga      300

ccctactata ctaagaacga ggactactgg ggccaaggca ccattctcac agtctcctca      360


<210>  10
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  10
gacatccaga tgactcagtc tccagcctcc ctggctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gcacatttac tacagtttag catggtatca gcagaagcaa      120

gggaaatctc ctcagctcct gatctataat gcaaacagct tggaagatgg tgtcccatcg      180

aggttcagtg gcagtggatc tgggacacaa tattctatga agatcaacag catgcagcct      240

gaagataccg caacttattt ctgtaaacag gcttatgacg ttcctcggac cttcggtgga      300

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatcc                   348


<210>  11
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  11

Thr Ser Tyr Gly Ile Ser 
1               5       


<210>  12
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  12

Ile Tyr Cys Ile His 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  13

Glu Ile Ser Pro Ser Asn Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  14
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  14

Ser Asp Gly Tyr Asp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Asn 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  16

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Leu Gln Tyr Ala Ser Tyr Pro Arg Thr 
1               5                   


<210>  18
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  18

Gln Val Gln Leu Leu Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Cys Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Pro Ser Asn Gly Arg Thr Ile Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Cys Cys 
                85                  90                  95      


Ala Ile Ser Asp Gly Tyr Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  20
caggtccaac tgctgcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc atctactgta tacactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attagtccta gcaacggtcg tactatctac      180

aatgagaagt tcaagaacaa ggccacactg actatagaca aatcctccac cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attgctgtgc aatatcggat      300

ggttacgacg gatactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  21
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  21
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa actggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag acttgagtct      240

gaagattttg cagactatta ctgtctacaa tatgctagtt atcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


