                         SEQUENCE LISTING

<110>  IST Austria (Institute of Science and Technology Austria)
       CeMM - Forschungszentrum fr Molekulare Medizin GmbH
 
<120>  ROS1 POSITIVE CANCER TREATMENT

<130>  IT002P

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  1

His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val 
1               5                   10                  15      


Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala 
            20                  25                  30          


Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr 
        35                  40                  45              


Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr 
    50                  55                  60                  


Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly 
65                  70                  75                  80  


Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala 
                85                  90                  95      


Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe 
            100                 105                 110         


Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu 
        115                 120                 125             


Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu 
    130                 135                 140                 


Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg 
145                 150                 155                 160 


Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp 
                165                 170                 175     


Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His 
            180                 185                 190         


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys 
        195                 200                 205             


Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala 
    210                 215                 220                 


Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe 
                245                 250                 255     


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile 
            260                 265                 270         


Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val 
        275                 280                 285             


Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys 
    290                 295                 300                 


Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro 
305                 310                 315                 320 


Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe 
                325                 330                 335     


Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn 
            340                 345                 350         


Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val 
        355                 360                 365             


Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr 
    370                 375                 380                 


Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly 
385                 390                 395                 400 


Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu 
                405                 410                 415     


Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp 
            420                 425                 430         


Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu 
        435                 440                 445             


Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser 
    450                 455                 460                 


Asp 
465 


<210>  2
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  2

His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val 
1               5                   10                  15      


Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala 
            20                  25                  30          


Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr 
        35                  40                  45              


Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr 
    50                  55                  60                  


Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly 
65                  70                  75                  80  


Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala 
                85                  90                  95      


Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe 
            100                 105                 110         


Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu 
        115                 120                 125             


Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu 
    130                 135                 140                 


Glu Leu Met Glu Gly Arg Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg 
145                 150                 155                 160 


Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp 
                165                 170                 175     


Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His 
            180                 185                 190         


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys 
        195                 200                 205             


Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala 
    210                 215                 220                 


Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe 
                245                 250                 255     


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile 
            260                 265                 270         


Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val 
        275                 280                 285             


Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys 
    290                 295                 300                 


Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro 
305                 310                 315                 320 


Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe 
                325                 330                 335     


Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn 
            340                 345                 350         


Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val 
        355                 360                 365             


Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr 
    370                 375                 380                 


Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly 
385                 390                 395                 400 


Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu 
                405                 410                 415     


Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp 
            420                 425                 430         


Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu 
        435                 440                 445             


Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser 
    450                 455                 460                 


Asp 
465 


<210>  3
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  3
gatcgctctt cagaccatag aagattaaag aatcaaaaaa g                           41


<210>  4
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  4
gatcgctctt ccaggatcag acccatctcc atatccactg                             40


<210>  5
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Olegonucleotide

<400>  5
aataagtaag aaggtctctt ccctccatca gttccag                                37


<210>  6
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Olegonucleotide

<400>  6
ctggaactga tggagggaag agaccttctt acttatt                                37


<210>  7
<211>  1273
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys 
        115                 120                 125             


Met Ala Gly Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu 
    130                 135                 140                 


Leu Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser 
145                 150                 155                 160 


Ser Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser Ser Leu Leu 
                165                 170                 175     


Thr Val Arg Ala Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr 
            180                 185                 190         


Ser Ile Thr Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser 
        195                 200                 205             


Glu Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn 
    210                 215                 220                 


Trp Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr 
225                 230                 235                 240 


Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn 
                245                 250                 255     


Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr 
            260                 265                 270         


Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala Met 
        275                 280                 285             


Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile Trp Cys Lys 
    290                 295                 300                 


Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr Val Pro Ser Thr Ala 
305                 310                 315                 320 


Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr Asp Gly Ile Gln Asn Trp 
                325                 330                 335     


Thr Met Lys Asn Val Thr Tyr Lys Glu Asn Ile Ala Lys Cys Gln His 
            340                 345                 350         


Ile Phe Val Asn Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu 
        355                 360                 365             


Leu Ile Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val 
    370                 375                 380                 


Lys Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys 
385                 390                 395                 400 


Lys Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly 
                405                 410                 415     


Tyr Leu Ala Ile Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser 
            420                 425                 430         


Ser Ser Val Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val 
        435                 440                 445             


Ile Thr Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly 
    450                 455                 460                 


Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala 
465                 470                 475                 480 


Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile 
                485                 490                 495     


Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile 
            500                 505                 510         


Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp Phe 
        515                 520                 525             


Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro Leu Thr Val 
    530                 535                 540                 


Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu Val Gly Val Gly Val 
545                 550                 555                 560 


Pro Val Val Phe Ile Ile Ile Leu Val Leu Cys Leu Arg Leu Leu Gln 
                565                 570                 575     


Ser Arg Cys Pro Arg Val Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe 
            580                 585                 590         


Leu Pro Leu Trp Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser 
        595                 600                 605             


Lys Phe Thr Gly Cys Phe Gln Met Arg Cys Cys Cys Cys Cys Arg Val 
    610                 615                 620                 


Cys Cys Arg Ala Cys Cys Leu Leu Cys Gly Cys Pro Lys Cys Cys Arg 
625                 630                 635                 640 


Cys Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp 
                645                 650                 655     


Val Pro Val Lys Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg 
            660                 665                 670         


Glu Ala Gln Ala Gly Val Pro Asn Lys Pro Gly Ile Pro Lys Leu Leu 
        675                 680                 685             


Glu Gly Ser Lys Asn Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn Gly 
    690                 695                 700                 


Cys Arg Ile Thr Tyr Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser Asn 
705                 710                 715                 720 


Asn Leu Gln Asn Gln Asn Leu Arg Trp Lys Met Thr Phe Asn Gly Ser 
                725                 730                 735     


Cys Ser Ser Val Cys Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile Phe 
            740                 745                 750         


Gln Phe Arg Val Val Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr Ser 
        755                 760                 765             


Gly Ile Ser Glu Asn Ile Ile Leu Val Gly Asp Asp Phe Trp Ile Pro 
    770                 775                 780                 


Glu Thr Ser Phe Ile Leu Thr Ile Ile Val Gly Ile Phe Leu Val Val 
785                 790                 795                 800 


Thr Ile Pro Leu Thr Phe Val Trp His Arg Arg Leu Lys Asn Gln Lys 
                805                 810                 815     


Ser Ala Lys Glu Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu 
            820                 825                 830         


Ala Glu Leu Arg Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys 
        835                 840                 845             


Tyr Ala Ile His Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro 
    850                 855                 860                 


Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly 
865                 870                 875                 880 


Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val 
                885                 890                 895     


Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser 
            900                 905                 910         


Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser 
        915                 920                 925             


Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu 
    930                 935                 940                 


Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu 
945                 950                 955                 960 


Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu 
                965                 970                 975     


Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly 
            980                 985                 990         


Cys Val Tyr Leu Glu Arg Met His  Phe Ile His Arg Asp  Leu Ala Ala 
        995                 1000                 1005             


Arg Asn  Cys Leu Val Ser Val  Lys Asp Tyr Thr Ser  Pro Arg Ile 
    1010                 1015                 1020             


Val Lys  Ile Gly Asp Phe Gly  Leu Ala Arg Asp Ile  Tyr Lys Asn 
    1025                 1030                 1035             


Asp Tyr  Tyr Arg Lys Arg Gly  Glu Gly Leu Leu Pro  Val Arg Trp 
    1040                 1045                 1050             


Met Ala  Pro Glu Ser Leu Met  Asp Gly Ile Phe Thr  Thr Gln Ser 
    1055                 1060                 1065             


Asp Val  Trp Ser Phe Gly Ile  Leu Ile Trp Glu Ile  Leu Thr Leu 
    1070                 1075                 1080             


Gly His  Gln Pro Tyr Pro Ala  His Ser Asn Leu Asp  Val Leu Asn 
    1085                 1090                 1095             


Tyr Val  Gln Thr Gly Gly Arg  Leu Glu Pro Pro Arg  Asn Cys Pro 
    1100                 1105                 1110             


Asp Asp  Leu Trp Asn Leu Met  Thr Gln Cys Trp Ala  Gln Glu Pro 
    1115                 1120                 1125             


Asp Gln  Arg Pro Thr Phe His  Arg Ile Gln Asp Gln  Leu Gln Leu 
    1130                 1135                 1140             


Phe Arg  Asn Phe Phe Leu Asn  Ser Ile Tyr Lys Ser  Arg Asp Glu 
    1145                 1150                 1155             


Ala Asn  Asn Ser Gly Val Ile  Asn Glu Ser Phe Glu  Gly Glu Asp 
    1160                 1165                 1170             


Gly Asp  Val Ile Cys Leu Asn  Ser Asp Asp Ile Met  Pro Val Ala 
    1175                 1180                 1185             


Leu Met  Glu Thr Lys Asn Arg  Glu Gly Leu Asn Tyr  Met Val Leu 
    1190                 1195                 1200             


Ala Thr  Glu Cys Gly Gln Gly  Glu Glu Lys Ser Glu  Gly Pro Leu 
    1205                 1210                 1215             


Gly Ser  Gln Glu Ser Glu Ser  Cys Gly Leu Arg Lys  Glu Glu Lys 
    1220                 1225                 1230             


Glu Pro  His Ala Asp Lys Asp  Phe Cys Gln Glu Lys  Gln Val Ala 
    1235                 1240                 1245             


Tyr Cys  Pro Ser Gly Lys Pro  Glu Gly Leu Asn Tyr  Ala Cys Leu 
    1250                 1255                 1260             


Thr His  Ser Gly Tyr Gly Asp  Gly Ser Asp 
    1265                 1270             


<210>  8
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Ala Gly 
        115                 120                 125             


Val Pro Asn Lys Pro Gly Ile Pro Lys Leu Leu Glu Gly Ser Lys Asn 
    130                 135                 140                 


Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn Gly Cys Arg Ile Thr Tyr 
145                 150                 155                 160 


Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser Asn Asn Leu Gln Asn Gln 
                165                 170                 175     


Asn Leu Arg Trp Lys Met Thr Phe Asn Gly Ser Cys Ser Ser Val Cys 
            180                 185                 190         


Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile Phe Gln Phe Arg Val Val 
        195                 200                 205             


Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr Ser Gly Ile Ser Glu Asn 
    210                 215                 220                 


Ile Ile Leu Val Gly Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile 
225                 230                 235                 240 


Leu Thr Ile Ile Val Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr 
                245                 250                 255     


Phe Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly 
            260                 265                 270         


Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly 
        275                 280                 285             


Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr 
    290                 295                 300                 


Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu 
305                 310                 315                 320 


Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val 
                325                 330                 335     


Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile 
            340                 345                 350         


Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys 
        355                 360                 365             


Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro 
    370                 375                 380                 


Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr 
385                 390                 395                 400 


Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg 
                405                 410                 415     


Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp 
            420                 425                 430         


Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu 
        435                 440                 445             


Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    450                 455                 460                 


Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe 
465                 470                 475                 480 


Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly 
                485                 490                 495     


Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp 
            500                 505                 510         


Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile 
        515                 520                 525             


Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn 
    530                 535                 540                 


Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro 
545                 550                 555                 560 


Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala 
                565                 570                 575     


Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu 
            580                 585                 590         


Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp 
        595                 600                 605             


Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp 
    610                 615                 620                 


Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu 
625                 630                 635                 640 


Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr 
                645                 650                 655     


Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln 
            660                 665                 670         


Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala 
        675                 680                 685             


Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly 
    690                 695                 700                 


Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly 
705                 710                 715                 720 


Asp Gly Ser Asp 
                


<210>  9
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Ala Gly Val Pro Asn Lys Pro Gly Ile Pro Lys Leu Leu Glu Gly Ser 
    210                 215                 220                 


Lys Asn Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn Gly Cys Arg Ile 
225                 230                 235                 240 


Thr Tyr Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser Asn Asn Leu Gln 
                245                 250                 255     


Asn Gln Asn Leu Arg Trp Lys Met Thr Phe Asn Gly Ser Cys Ser Ser 
            260                 265                 270         


Val Cys Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile Phe Gln Phe Arg 
        275                 280                 285             


Val Val Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr Ser Gly Ile Ser 
    290                 295                 300                 


Glu Asn Ile Ile Leu Val Gly Asp Asp Phe Trp Ile Pro Glu Thr Ser 
305                 310                 315                 320 


Phe Ile Leu Thr Ile Ile Val Gly Ile Phe Leu Val Val Thr Ile Pro 
                325                 330                 335     


Leu Thr Phe Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys 
            340                 345                 350         


Glu Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu 
        355                 360                 365             


Arg Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile 
    370                 375                 380                 


His Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro 
385                 390                 395                 400 


Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly 
                405                 410                 415     


Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly 
            420                 425                 430         


Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln 
        435                 440                 445             


Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn 
    450                 455                 460                 


His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro 
465                 470                 475                 480 


Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr 
                485                 490                 495     


Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu 
            500                 505                 510         


Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr 
        515                 520                 525             


Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
    530                 535                 540                 


Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly 
545                 550                 555                 560 


Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys 
                565                 570                 575     


Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu 
            580                 585                 590         


Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile 
        595                 600                 605             


Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His 
    610                 615                 620                 


Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu 
625                 630                 635                 640 


Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys 
                645                 650                 655     


Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp 
            660                 665                 670         


Gln Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser 
        675                 680                 685             


Arg Asp Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly 
    690                 695                 700                 


Glu Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val 
705                 710                 715                 720 


Ala Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu 
                725                 730                 735     


Ala Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly 
            740                 745                 750         


Ser Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro 
        755                 760                 765             


His Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro 
    770                 775                 780                 


Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly 
785                 790                 795                 800 


Tyr Gly Asp Gly Ser Asp 
                805     


<210>  10
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  10

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu Thr Ile Ile Val 
    210                 215                 220                 


Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr Phe Val Trp His Arg 
225                 230                 235                 240 


Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile 
                245                 250                 255     


Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val 
            260                 265                 270         


Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu 
        275                 280                 285             


Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg 
    290                 295                 300                 


Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala 
305                 310                 315                 320 


Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys 
                325                 330                 335     


Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys 
            340                 345                 350         


Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln 
        355                 360                 365             


Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu 
    370                 375                 380                 


Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala 
385                 390                 395                 400 


Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys 
                405                 410                 415     


Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile 
            420                 425                 430         


His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr 
        435                 440                 445             


Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp 
    450                 455                 460                 


Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro 
465                 470                 475                 480 


Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr 
                485                 490                 495     


Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr 
            500                 505                 510         


Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn 
        515                 520                 525             


Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp 
    530                 535                 540                 


Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln 
545                 550                 555                 560 


Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn 
                565                 570                 575     


Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser 
            580                 585                 590         


Gly Val Ile Asn Glu Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys 
        595                 600                 605             


Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn 
    610                 615                 620                 


Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly 
625                 630                 635                 640 


Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys 
                645                 650                 655     


Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys 
            660                 665                 670         


Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu 
        675                 680                 685             


Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
    690                 695                 700             


<210>  11
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Asp Asp Phe Trp Ile 
        355                 360                 365             


Pro Glu Thr Ser Phe Ile Leu Thr Ile Ile Val Gly Ile Phe Leu Val 
    370                 375                 380                 


Val Thr Ile Pro Leu Thr Phe Val Trp His Arg Arg Leu Lys Asn Gln 
385                 390                 395                 400 


Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu 
                405                 410                 415     


Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala 
            420                 425                 430         


Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu 
        435                 440                 445             


Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser 
    450                 455                 460                 


Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly 
465                 470                 475                 480 


Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly 
                485                 490                 495     


Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met 
            500                 505                 510         


Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu 
        515                 520                 525             


Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp 
    530                 535                 540                 


Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro 
545                 550                 555                 560 


Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys 
                565                 570                 575     


Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala 
            580                 585                 590         


Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile 
        595                 600                 605             


Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp 
    610                 615                 620                 


Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala 
625                 630                 635                 640 


Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp 
                645                 650                 655     


Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro 
            660                 665                 670         


Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly 
        675                 680                 685             


Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu 
    690                 695                 700                 


Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His 
705                 710                 715                 720 


Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser 
                725                 730                 735     


Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser Gly Val Ile Asn Glu 
            740                 745                 750         


Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp 
        755                 760                 765             


Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn 
    770                 775                 780                 


Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu 
785                 790                 795                 800 


Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu 
                805                 810                 815     


Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val 
            820                 825                 830         


Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu 
        835                 840                 845             


Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
    850                 855             


<210>  12
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg 
            180                 185                 190         


Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu 
        195                 200                 205             


Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala 
225                 230                 235                 240 


Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp 
                245                 250                 255     


Leu Glu Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu 
            260                 265                 270         


Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg 
        275                 280                 285             


Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His 
    290                 295                 300                 


Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg 
305                 310                 315                 320 


Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu 
                325                 330                 335     


Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu 
            340                 345                 350         


Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu 
        355                 360                 365             


Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His 
    370                 375                 380                 


Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln 
385                 390                 395                 400 


Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu 
                405                 410                 415     


Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val 
            420                 425                 430         


Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu 
        435                 440                 445             


Glu Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
    450                 455                 460                 


Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp 
465                 470                 475                 480 


Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg 
                485                 490                 495     


Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met 
            500                 505                 510         


Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu 
        515                 520                 525             


Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser 
    530                 535                 540                 


Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro 
545                 550                 555                 560 


Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp 
                565                 570                 575     


Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln 
            580                 585                 590         


Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg 
        595                 600                 605             


Asp Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe Glu Gly Glu 
    610                 615                 620                 


Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala 
625                 630                 635                 640 


Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala 
                645                 650                 655     


Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser 
            660                 665                 670         


Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His 
        675                 680                 685             


Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser 
    690                 695                 700                 


Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr 
705                 710                 715                 720 


Gly Asp Gly Ser Asp 
                725 


<210>  13
<211>  1365
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Ala Pro Ser Leu Arg Ala Arg Ala Ala Gly Leu Gly Leu Leu 
1               5                   10                  15      


Leu Cys Ala Val Leu Gly Arg Ala Gly Arg Ser Asp Ser Gly Gly Arg 
            20                  25                  30          


Gly Glu Leu Gly Gln Pro Ser Gly Val Ala Ala Glu Arg Pro Cys Pro 
        35                  40                  45              


Thr Thr Cys Arg Cys Leu Gly Asp Leu Leu Asp Cys Ser Arg Lys Arg 
    50                  55                  60                  


Leu Ala Arg Leu Pro Glu Pro Leu Pro Ser Trp Val Ala Arg Leu Asp 
65                  70                  75                  80  


Leu Ser His Asn Arg Leu Ser Phe Ile Lys Ala Ser Ser Met Ser His 
                85                  90                  95      


Leu Gln Ser Leu Arg Glu Val Lys Leu Asn Asn Asn Glu Leu Glu Thr 
            100                 105                 110         


Ile Pro Asn Leu Gly Pro Val Ser Ala Asn Ile Thr Leu Leu Ser Leu 
        115                 120                 125             


Ala Gly Asn Arg Ile Val Glu Ile Leu Pro Glu His Leu Lys Glu Phe 
    130                 135                 140                 


Gln Ser Leu Glu Thr Leu Asp Leu Ser Ser Asn Asn Ile Ser Glu Leu 
145                 150                 155                 160 


Gln Thr Ala Phe Pro Ala Leu Gln Leu Lys Tyr Leu Tyr Leu Asn Ser 
                165                 170                 175     


Asn Arg Val Thr Ser Met Glu Pro Gly Tyr Phe Asp Asn Leu Ala Asn 
            180                 185                 190         


Thr Leu Leu Val Leu Lys Leu Asn Arg Asn Arg Ile Ser Ala Ile Pro 
        195                 200                 205             


Pro Lys Met Phe Lys Leu Pro Gln Leu Gln His Leu Glu Leu Asn Arg 
    210                 215                 220                 


Asn Lys Ile Lys Asn Val Asp Gly Leu Thr Phe Gln Gly Leu Gly Ala 
225                 230                 235                 240 


Leu Lys Ser Leu Lys Met Gln Arg Asn Gly Val Thr Lys Leu Met Asp 
                245                 250                 255     


Gly Ala Phe Trp Gly Leu Ser Asn Met Glu Ile Leu Gln Leu Asp His 
            260                 265                 270         


Asn Asn Leu Thr Glu Ile Thr Lys Gly Trp Leu Tyr Gly Leu Leu Met 
        275                 280                 285             


Leu Gln Glu Leu His Leu Ser Gln Asn Ala Ile Asn Arg Ile Ser Pro 
    290                 295                 300                 


Asp Ala Trp Glu Phe Cys Gln Lys Leu Ser Glu Leu Asp Leu Thr Phe 
305                 310                 315                 320 


Asn His Leu Ser Arg Leu Asp Asp Ser Ser Phe Leu Gly Leu Ser Leu 
                325                 330                 335     


Leu Asn Thr Leu His Ile Gly Asn Asn Arg Val Ser Tyr Ile Ala Asp 
            340                 345                 350         


Cys Ala Phe Arg Gly Leu Ser Ser Leu Lys Thr Leu Asp Leu Lys Asn 
        355                 360                 365             


Asn Glu Ile Ser Trp Thr Ile Glu Asp Met Asn Gly Ala Phe Ser Gly 
    370                 375                 380                 


Leu Asp Lys Leu Arg Arg Leu Ile Leu Gln Gly Asn Arg Ile Arg Ser 
385                 390                 395                 400 


Ile Thr Lys Lys Ala Phe Thr Gly Leu Asp Ala Leu Glu His Leu Asp 
                405                 410                 415     


Leu Ser Asp Asn Ala Ile Met Ser Leu Gln Gly Asn Ala Phe Ser Gln 
            420                 425                 430         


Met Lys Lys Leu Gln Gln Leu His Leu Asn Thr Ser Ser Leu Leu Cys 
        435                 440                 445             


Asp Cys Gln Leu Lys Trp Leu Pro Gln Trp Val Ala Glu Asn Asn Phe 
    450                 455                 460                 


Gln Ser Phe Val Asn Ala Ser Cys Ala His Pro Gln Leu Leu Lys Gly 
465                 470                 475                 480 


Arg Ser Ile Phe Ala Val Ser Pro Asp Gly Phe Val Cys Asp Asp Phe 
                485                 490                 495     


Pro Lys Pro Gln Ile Thr Val Gln Pro Glu Thr Gln Ser Ala Ile Lys 
            500                 505                 510         


Gly Ser Asn Leu Ser Phe Ile Cys Ser Ala Ala Ser Ser Ser Asp Ser 
        515                 520                 525             


Pro Met Thr Phe Ala Trp Lys Lys Asp Asn Glu Leu Leu His Asp Ala 
    530                 535                 540                 


Glu Met Glu Asn Tyr Ala His Leu Arg Ala Gln Gly Gly Glu Val Met 
545                 550                 555                 560 


Glu Tyr Thr Thr Ile Leu Arg Leu Arg Glu Val Glu Phe Ala Ser Glu 
                565                 570                 575     


Gly Lys Tyr Gln Cys Val Ile Ser Asn His Phe Gly Ser Ser Tyr Ser 
            580                 585                 590         


Val Lys Ala Lys Leu Thr Val Asn Met Leu Pro Ser Phe Thr Lys Thr 
        595                 600                 605             


Pro Met Asp Leu Thr Ile Arg Ala Gly Ala Met Ala Arg Leu Glu Cys 
    610                 615                 620                 


Ala Ala Val Gly His Pro Ala Pro Gln Ile Ala Trp Gln Lys Asp Gly 
625                 630                 635                 640 


Gly Thr Asp Phe Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro 
                645                 650                 655     


Glu Asp Asp Val Phe Phe Ile Val Asp Val Lys Ile Glu Asp Ile Gly 
            660                 665                 670         


Val Tyr Ser Cys Thr Ala Gln Asn Ser Ala Gly Ser Ile Ser Ala Asn 
        675                 680                 685             


Ala Thr Leu Thr Val Leu Glu Thr Pro Ser Phe Leu Arg Pro Leu Leu 
    690                 695                 700                 


Asp Arg Thr Val Thr Lys Gly Glu Thr Ala Val Leu Gln Cys Ile Ala 
705                 710                 715                 720 


Gly Gly Ser Pro Pro Pro Lys Leu Asn Trp Thr Lys Asp Asp Ser Pro 
                725                 730                 735     


Leu Val Val Thr Glu Arg His Phe Phe Ala Ala Gly Asn Gln Leu Leu 
            740                 745                 750         


Ile Ile Val Asp Ser Asp Val Ser Asp Ala Gly Lys Tyr Thr Cys Glu 
        755                 760                 765             


Met Ser Asn Thr Leu Gly Thr Glu Arg Gly Asn Val Arg Leu Ser Val 
    770                 775                 780                 


Ile Pro Thr Pro Thr Cys Asp Ser Pro Gln Met Thr Ala Pro Ser Leu 
785                 790                 795                 800 


Asp Asp Asp Gly Trp Ala Thr Val Gly Val Val Ile Ile Ala Val Val 
                805                 810                 815     


Cys Cys Val Val Gly Thr Ser Leu Val Trp Val Val Ile Ile Tyr His 
            820                 825                 830         


Thr Arg Arg Arg Asn Glu Asp Cys Ser Ile Thr Asn Thr Asp Glu Thr 
        835                 840                 845             


Asn Leu Pro Ala Asp Ile Pro Ser Tyr Leu Ser Ser Gln Gly Thr Leu 
    850                 855                 860                 


Ala Asp Arg Gln Asp Gly Tyr Val Ser Ser Glu Ser Gly Ser His His 
865                 870                 875                 880 


Gln Phe Val Thr Ser Ser Gly Ala Gly Phe Phe Leu Pro Gln His Asp 
                885                 890                 895     


Ser Ser Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu 
            900                 905                 910         


Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg 
        915                 920                 925             


Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His 
    930                 935                 940                 


Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg 
945                 950                 955                 960 


Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu 
                965                 970                 975     


Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu 
            980                 985                 990         


Ile Lys Val Ala Val Lys Thr Leu  Lys Lys Gly Ser Thr  Asp Gln Glu 
        995                 1000                 1005             


Lys Ile  Glu Phe Leu Lys Glu  Ala His Leu Met Ser  Lys Phe Asn 
    1010                 1015                 1020             


His Pro  Asn Ile Leu Lys Gln  Leu Gly Val Cys Leu  Leu Asn Glu 
    1025                 1030                 1035             


Pro Gln  Tyr Ile Ile Leu Glu  Leu Met Glu Gly Gly  Asp Leu Leu 
    1040                 1045                 1050             


Thr Tyr  Leu Arg Lys Ala Arg  Met Ala Thr Phe Tyr  Gly Pro Leu 
    1055                 1060                 1065             


Leu Thr  Leu Val Asp Leu Val  Asp Leu Cys Val Asp  Ile Ser Lys 
    1070                 1075                 1080             


Gly Cys  Val Tyr Leu Glu Arg  Met His Phe Ile His  Arg Asp Leu 
    1085                 1090                 1095             


Ala Ala  Arg Asn Cys Leu Val  Ser Val Lys Asp Tyr  Thr Ser Pro 
    1100                 1105                 1110             


Arg Ile  Val Lys Ile Gly Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr 
    1115                 1120                 1125             


Lys Asn  Asp Tyr Tyr Arg Lys  Arg Gly Glu Gly Leu  Leu Pro Val 
    1130                 1135                 1140             


Arg Trp  Met Ala Pro Glu Ser  Leu Met Asp Gly Ile  Phe Thr Thr 
    1145                 1150                 1155             


Gln Ser  Asp Val Trp Ser Phe  Gly Ile Leu Ile Trp  Glu Ile Leu 
    1160                 1165                 1170             


Thr Leu  Gly His Gln Pro Tyr  Pro Ala His Ser Asn  Leu Asp Val 
    1175                 1180                 1185             


Leu Asn  Tyr Val Gln Thr Gly  Gly Arg Leu Glu Pro  Pro Arg Asn 
    1190                 1195                 1200             


Cys Pro  Asp Asp Leu Trp Asn  Leu Met Thr Gln Cys  Trp Ala Gln 
    1205                 1210                 1215             


Glu Pro  Asp Gln Arg Pro Thr  Phe His Arg Ile Gln  Asp Gln Leu 
    1220                 1225                 1230             


Gln Leu  Phe Arg Asn Phe Phe  Leu Asn Ser Ile Tyr  Lys Ser Arg 
    1235                 1240                 1245             


Asp Glu  Ala Asn Asn Ser Gly  Val Ile Asn Glu Ser  Phe Glu Gly 
    1250                 1255                 1260             


Glu Asp  Gly Asp Val Ile Cys  Leu Asn Ser Asp Asp  Ile Met Pro 
    1265                 1270                 1275             


Val Ala  Leu Met Glu Thr Lys  Asn Arg Glu Gly Leu  Asn Tyr Met 
    1280                 1285                 1290             


Val Leu  Ala Thr Glu Cys Gly  Gln Gly Glu Glu Lys  Ser Glu Gly 
    1295                 1300                 1305             


Pro Leu  Gly Ser Gln Glu Ser  Glu Ser Cys Gly Leu  Arg Lys Glu 
    1310                 1315                 1320             


Glu Lys  Glu Pro His Ala Asp  Lys Asp Phe Cys Gln  Glu Lys Gln 
    1325                 1330                 1335             


Val Ala  Tyr Cys Pro Ser Gly  Lys Pro Glu Gly Leu  Asn Tyr Ala 
    1340                 1345                 1350             


Cys Leu  Thr His Ser Gly Tyr  Gly Asp Gly Ser Asp  
    1355                 1360                 1365 


<210>  14
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Asp Asp Phe Trp Ile Pro Glu Thr Ser Phe Ile Leu 
145                 150                 155                 160 


Thr Ile Ile Val Gly Ile Phe Leu Val Val Thr Ile Pro Leu Thr Phe 
                165                 170                 175     


Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser Ala Lys Glu Gly Val 
            180                 185                 190         


Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala Glu Leu Arg Gly Leu 
        195                 200                 205             


Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr Ala Ile His Thr Leu 
    210                 215                 220                 


Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala Phe Pro Arg Glu Lys 
225                 230                 235                 240 


Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala Phe Gly Glu Val Tyr 
                245                 250                 255     


Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly Ser Gly Glu Ile Lys 
            260                 265                 270         


Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr Asp Gln Glu Lys Ile 
        275                 280                 285             


Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys Phe Asn His Pro Asn 
    290                 295                 300                 


Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn Glu Pro Gln Tyr Ile 
305                 310                 315                 320 


Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu Thr Tyr Leu Arg Lys 
                325                 330                 335     


Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu Thr Leu Val Asp Leu 
            340                 345                 350         


Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys Val Tyr Leu Glu Arg 
        355                 360                 365             


Met His Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Ser 
    370                 375                 380                 


Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys Ile Gly Asp Phe Gly 
385                 390                 395                 400 


Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr Arg Lys Arg Gly Glu 
                405                 410                 415     


Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu Ser Leu Met Asp Gly 
            420                 425                 430         


Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Ile Trp 
        435                 440                 445             


Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro Ala His Ser Asn Leu 
    450                 455                 460                 


Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg Leu Glu Pro Pro Arg 
465                 470                 475                 480 


Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr Gln Cys Trp Ala Gln 
                485                 490                 495     


Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile Gln Asp Gln Leu Gln 
            500                 505                 510         


Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr Lys Ser Arg Asp Glu 
        515                 520                 525             


Ala Asn Asn Ser Gly Val Ile Lys Glu Ser Phe Glu Gly Glu Asp Gly 
    530                 535                 540                 


Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met Pro Val Ala Leu Met 
545                 550                 555                 560 


Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met Val Leu Ala Thr Glu 
                565                 570                 575     


Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro Leu Gly Ser Gln Glu 
            580                 585                 590         


Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys Glu Pro His Ala Asp 
        595                 600                 605             


Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr Cys Pro Ser Gly Lys 
    610                 615                 620                 


Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His Ser Gly Tyr Gly Asp 
625                 630                 635                 640 


Gly Ser Asp 
            


<210>  15
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Gly Val Pro Asn Lys Pro Gly Ile Pro Lys Leu 
145                 150                 155                 160 


Leu Glu Gly Ser Lys Asn Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn 
                165                 170                 175     


Gly Cys Arg Ile Thr Tyr Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser 
            180                 185                 190         


Asn Asn Leu Gln Asn Gln Asn Leu Arg Trp Lys Met Thr Phe Asn Gly 
        195                 200                 205             


Ser Cys Ser Ser Val Cys Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile 
    210                 215                 220                 


Phe Gln Phe Arg Val Val Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr 
225                 230                 235                 240 


Ser Gly Ile Ser Glu Asn Ile Ile Leu Val Gly Asp Asp Phe Trp Ile 
                245                 250                 255     


Pro Glu Thr Ser Phe Ile Leu Thr Ile Ile Val Gly Ile Phe Leu Val 
            260                 265                 270         


Val Thr Ile Pro Leu Thr Phe Val Trp His Arg Arg Leu Lys Asn Gln 
        275                 280                 285             


Lys Ser Ala Lys Glu Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu 
    290                 295                 300                 


Leu Ala Glu Leu Arg Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala 
305                 310                 315                 320 


Cys Tyr Ala Ile His Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu 
                325                 330                 335     


Pro Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser 
            340                 345                 350         


Gly Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly 
        355                 360                 365             


Val Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly 
    370                 375                 380                 


Ser Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met 
385                 390                 395                 400 


Ser Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu 
                405                 410                 415     


Leu Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp 
            420                 425                 430         


Leu Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro 
        435                 440                 445             


Leu Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys 
    450                 455                 460                 


Gly Cys Val Tyr Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala 
465                 470                 475                 480 


Ala Arg Asn Cys Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile 
                485                 490                 495     


Val Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp 
            500                 505                 510         


Tyr Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala 
        515                 520                 525             


Pro Glu Ser Leu Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp 
    530                 535                 540                 


Ser Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro 
545                 550                 555                 560 


Tyr Pro Ala His Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly 
                565                 570                 575     


Gly Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu 
            580                 585                 590         


Met Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His 
        595                 600                 605             


Arg Ile Gln Asp Gln Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser 
    610                 615                 620                 


Ile Tyr Lys Ser Arg Asp Glu Ala Asn Asn Ser Gly Val Ile Lys Glu 
625                 630                 635                 640 


Ser Phe Glu Gly Glu Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp 
                645                 650                 655     


Ile Met Pro Val Ala Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn 
            660                 665                 670         


Tyr Met Val Leu Ala Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu 
        675                 680                 685             


Gly Pro Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu 
    690                 695                 700                 


Glu Lys Glu Pro His Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val 
705                 710                 715                 720 


Ala Tyr Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu 
                725                 730                 735     


Thr His Ser Gly Tyr Gly Asp Gly Ser Asp 
            740                 745     


<210>  16
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Leu Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Ala Gly Val Pro Asn Lys Pro Gly Ile Pro Lys Leu Leu Glu 
65                  70                  75                  80  


Gly Ser Lys Asn Ser Ile Gln Trp Glu Lys Ala Glu Asp Asn Gly Cys 
                85                  90                  95      


Arg Ile Thr Tyr Tyr Ile Leu Glu Ile Arg Lys Ser Thr Ser Asn Asn 
            100                 105                 110         


Leu Gln Asn Gln Asn Leu Arg Trp Lys Met Thr Phe Asn Gly Ser Cys 
        115                 120                 125             


Ser Ser Val Cys Thr Trp Lys Ser Lys Asn Leu Lys Gly Ile Phe Gln 
    130                 135                 140                 


Phe Arg Val Val Ala Ala Asn Asn Leu Gly Phe Gly Glu Tyr Ser Gly 
145                 150                 155                 160 


Ile Ser Glu Asn Ile Ile Leu Val Gly Asp Asp Phe Trp Ile Pro Glu 
                165                 170                 175     


Thr Ser Phe Ile Leu Thr Ile Ile Val Gly Ile Phe Leu Val Val Thr 
            180                 185                 190         


Ile Pro Leu Thr Phe Val Trp His Arg Arg Leu Lys Asn Gln Lys Ser 
        195                 200                 205             


Ala Lys Glu Gly Val Thr Val Leu Ile Asn Glu Asp Lys Glu Leu Ala 
    210                 215                 220                 


Glu Leu Arg Gly Leu Ala Ala Gly Val Gly Leu Ala Asn Ala Cys Tyr 
225                 230                 235                 240 


Ala Ile His Thr Leu Pro Thr Gln Glu Glu Ile Glu Asn Leu Pro Ala 
                245                 250                 255     


Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly Ala 
            260                 265                 270         


Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val Gly 
        275                 280                 285             


Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser Thr 
    290                 295                 300                 


Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser Lys 
305                 310                 315                 320 


Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu Asn 
                325                 330                 335     


Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu Leu 
            340                 345                 350         


Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu Leu 
        355                 360                 365             


Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly Cys 
    370                 375                 380                 


Val Tyr Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala Ala Arg 
385                 390                 395                 400 


Asn Cys Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val Lys 
                405                 410                 415     


Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr Tyr 
            420                 425                 430         


Arg Lys Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro Glu 
        435                 440                 445             


Ser Leu Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser Phe 
    450                 455                 460                 


Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr Pro 
465                 470                 475                 480 


Ala His Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly Arg 
                485                 490                 495     


Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met Thr 
            500                 505                 510         


Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg Ile 
        515                 520                 525             


Gln Asp Gln Leu Gln Leu Phe Arg Asn Phe Phe Leu Asn Ser Ile Tyr 
    530                 535                 540                 


Lys Ser Arg Asp Glu Ala Asn Asn Ser Gly Val Ile Asn Glu Ser Phe 
545                 550                 555                 560 


Glu Gly Glu Asp Gly Asp Val Ile Cys Leu Asn Ser Asp Asp Ile Met 
                565                 570                 575     


Pro Val Ala Leu Met Glu Thr Lys Asn Arg Glu Gly Leu Asn Tyr Met 
            580                 585                 590         


Val Leu Ala Thr Glu Cys Gly Gln Gly Glu Glu Lys Ser Glu Gly Pro 
        595                 600                 605             


Leu Gly Ser Gln Glu Ser Glu Ser Cys Gly Leu Arg Lys Glu Glu Lys 
    610                 615                 620                 


Glu Pro His Ala Asp Lys Asp Phe Cys Gln Glu Lys Gln Val Ala Tyr 
625                 630                 635                 640 


Cys Pro Ser Gly Lys Pro Glu Gly Leu Asn Tyr Ala Cys Leu Thr His 
                645                 650                 655     


Ser Gly Tyr Gly Asp Gly Ser Asp 
            660                 


