                         SEQUENCE LISTING

<110>  Immutep S.A.
 
<120>  Anti-LAG-3 Antibodies

<130>  P/73968.WO01

<150>  GB 1515572.4
<151>  2015-09-02

<150>  GB 1612437.2
<151>  2016-07-18

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Balb/c mouse

<400>  1

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly 
1               5                   10  


<210>  2
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  2

Ile Trp Trp Asp Asp Ile Lys 
1               5           


<210>  3
<211>  15
<212>  PRT
<213>  Balb/c mouse

<400>  3

Ala Arg Ile Val Glu Gly Ser Tyr Ser Ser Ser Tyr Phe Asp Val 
1               5                   10                  15  


<210>  4
<211>  6
<212>  PRT
<213>  Balb/c mouse

<400>  4

Gln Asp Val Ile Phe Asp 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Balb/c mouse

<400>  5

Ser Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Balb/c mouse

<400>  6

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  123
<212>  PRT
<213>  Balb/c mouse

<400>  7

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Leu Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Thr His Ile Trp Trp Asp Asp Ile Lys Arg Tyr Asn Pro Asp 
    50                  55                  60                  


Leu Arg Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Ile 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Glu Gly Ser Tyr Ser Ser Ser Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  107
<212>  PRT
<213>  Balb/c mouse

<400>  8

Asp Ile Val Met Thr Gln Pro His Lys Phe Met Ser Thr Ser Val Glu 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Phe Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Val Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  370
<212>  DNA
<213>  Balb/c mouse

<400>  9
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtctagg ctggattcgt      120

cagccatcag ggaagggtct ggagtggctg acacacattt ggtgggatga tatcaagcgc      180

tataacccag acctgaggag ccgactgact atctccaagg atacctccag cagccagatt      240

ttcctcaaga tcgccagtgt ggacactgca gatactgcca catattactg tgctcgaata      300

gtggagggtt catacagtag tagttacttc gatgtctggg gcgcagggac cacggtcacc      360

gtctcctcag                                                             370


<210>  10
<211>  322
<212>  DNA
<213>  Balb/c mouse

<400>  10
gacattgtga tgacccagcc tcacaaattc atgtccacat cagtggaaga cagggtcacc       60

atcacctgca aggccagtca ggatgtgatt tttgatgtag cctggtatca acagaaacca      120

ggacaatctc ctaaattact gatttactcg gcatcctccc gggtcagtgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagtag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcagcaa cactatagta ctccgtacac gttcggaggg      300

gggaccacgc tggaaataaa ac                                               322


<210>  11
<211>  10
<212>  PRT
<213>  Balb/c mouse

<400>  11

Gly Phe Ser Leu Asn Thr Ser Gly Met Gly 
1               5                   10  


<210>  12
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  12

Ile Trp Trp Asp Asp Val Lys 
1               5           


<210>  13
<211>  15
<212>  PRT
<213>  Balb/c mouse

<400>  13

Ala Arg Ile Glu Gly Asp Thr Tyr Tyr Asp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  14
<211>  6
<212>  PRT
<213>  Balb/c mouse

<400>  14

Gln Asp Val Ser Ile Ala 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  Balb/c mouse

<400>  15

Ser Ala Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Balb/c mouse

<400>  16

Gln Gln His Tyr Ser Ile Pro Trp Thr 
1               5                   


<210>  17
<211>  123
<212>  PRT
<213>  Balb/c mouse

<400>  17

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Thr His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Glu Gly Asp Thr Tyr Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  18
<211>  107
<212>  PRT
<213>  Balb/c mouse

<400>  18

Asp Ile Val Met Thr Gln Ser His Lys Leu Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Gly Leu Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  370
<212>  DNA
<213>  Balb/c mouse

<400>  19
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgaac acttctggta tgggtgtagg ctggattcgt      120

cagccatcag ggaagggtct ggagtggctg acacacattt ggtgggatga tgtcaagcgc      180

tataatccag ccctgaagag ccgactgact atctccaagg atacctccag cagccaggta      240

ttcctcaaga tcgccagtgt ggacactgca gatactgcca catactactg tgctcgaata      300

gagggggata cttactacga ctattacttt gactactggg gccaaggcgt cactctcaca      360

gtctcctcag                                                             370


<210>  20
<211>  322
<212>  DNA
<213>  Balb/c mouse

<400>  20
gacattgtga tgacccagtc tcacaaactc atgtccacat cagttggaga cgggctcagc       60

atcacctgca aggccagtca ggatgtgagc attgctgtag tctggtatca acagaaacca      120

ggacaatctc ctaaactgct gatttactcg gcatccttcc ggtacactgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcagcaa cattatagta ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa ac                                               322


<210>  21
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  21

Thr Ser Gly Met Gly Leu Gly 
1               5           


<210>  22
<211>  16
<212>  PRT
<213>  Balb/c mouse

<400>  22

His Ile Trp Trp Asp Asp Ile Lys Arg Tyr Asn Pro Asp Leu Arg Ser 
1               5                   10                  15      


<210>  23
<211>  13
<212>  PRT
<213>  Balb/c mouse

<400>  23

Ile Val Glu Gly Ser Tyr Ser Ser Ser Tyr Phe Asp Val 
1               5                   10              


<210>  24
<211>  11
<212>  PRT
<213>  Balb/c mouse

<400>  24

Lys Ala Ser Gln Asp Val Ile Phe Asp Val Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  25

Ser Ala Ser Ser Arg Val Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Balb/c mouse

<400>  26

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  27
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro 
    50                  55                  60                  


Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg Val Pro Val Arg 
            180                 185                 190         


Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln 
        195                 200                 205             


Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr Arg Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Thr 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln Glu Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Val 
            340                 345                 350         


Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser 
                405                 410                 415     


Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His Leu Leu Leu Phe Leu 
            420                 425                 430         


Thr Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr Gly Ala Phe Gly 
        435                 440                 445             


Phe His Leu Trp Arg Arg Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu 
    450                 455                 460                 


Glu Gln Gly Ile His Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu 
465                 470                 475                 480 


Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
                485                 490                 495     


Pro Glu Pro Glu Gln Leu 
            500         


<210>  28
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro 
    50                  55                  60                  


Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu 
    130                 135                 140                 


Gly Gln Ala Ser Met 
145                 


<210>  29
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu 
1               5                   10                  15      


Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe 
            20                  25                  30          


Arg Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His 
        35                  40                  45              


His Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp 
    50                  55                  60                  


Ser Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val 
65                  70                  75                  80  


Ser Ile Met Tyr Asn Leu Thr Val Leu Gly 
                85                  90  


<210>  30
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain of mouse monoclonal antibody 13E2, and a human IgG4 Fc 
       portion with an S228P mutation

<400>  30

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Leu Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Thr His Ile Trp Trp Asp Asp Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Asp Leu Arg Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Ser Gln Ile Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Val Glu Gly Ser Tyr Ser Ser Ser Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys 
465                 


<210>  31
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  31

Thr Ser Gly Met Gly Val Gly 
1               5           


<210>  32
<211>  16
<212>  PRT
<213>  Balb/c mouse

<400>  32

His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  33
<211>  13
<212>  PRT
<213>  Balb/c mouse

<400>  33

Ile Glu Gly Asp Thr Tyr Tyr Asp Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  34
<211>  11
<212>  PRT
<213>  Balb/c mouse

<400>  34

Lys Ala Ser Gln Asp Val Ser Ile Ala Val Val 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Balb/c mouse

<400>  35

Ser Ala Ser Phe Arg Tyr Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Balb/c mouse

<400>  36

Gln Gln His Tyr Ser Ile Pro Trp Thr 
1               5                   


<210>  37
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain of monoclonal antibody 13E2, and a wild-type human Ig 
       kappa (IgK) chain C portion

<400>  37

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Pro His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Glu Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ile Phe Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Val Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  38
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  39
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg 
1               5                   10                  15      


Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr Arg Ser Phe 
            20                  25                  30          


Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp Leu Leu Val 
        35                  40                  45              


Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln 
    50                  55                  60                  


Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln Glu Gln Gln 
65                  70                  75                  80  


Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
                85                  90      


<210>  40
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His 
1               5                   10                  15      


Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr 
            20                  25                  30  


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Hemagglutinin epitope tag

<400>  41

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  42
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  FLAG epitope tag

<400>  42

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  c-myc epitope tag

<400>  43

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  44
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  His5 affinity domain

<400>  44

His His His His His 
1               5   


<210>  45
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  HisX6 affinity domain

<400>  45

His His His His His His 
1               5       


<210>  46
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  c-myc affinity domain

<400>  46

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  StrepTag affinity domain

<400>  47

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  48
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity domain

<400>  48

Arg Tyr Ile Arg Ser 
1               5   


<210>  49
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity domain

<400>  49

Phe His His Thr 
1               


<210>  50
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity domain

<400>  50

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  51
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  51

Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
1               5                   10                  15      


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
            20                  25                  30          


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
        35                  40                  45              


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
    50                  55                  60                  


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
65                  70                  75                  80  


Pro Gly 
        


<210>  52
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  52

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  53

Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  54
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  54

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ile Leu Asn 
1               5                   10                  15      


Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  55
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  55

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  56
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  56

Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser 
            20                  25  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  57

Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  58
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  58

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr 
1               5                   10                  15      


Met Ala Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  59
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  59

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  60
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  60

Gln Ile Thr Leu Lys Glu Thr Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  61

Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Val Thr 
1               5                   10                  


<210>  62
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  62

Arg Val Thr Ile Arg Lys Asp Thr Ser Lys Asn Gln Val Ala Leu Thr 
1               5                   10                  15      


Met Thr Asn Met Asp Pro Leu Asp Thr Gly Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  63
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  63

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  64

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  65
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  65

Trp Ile Arg Gln Pro Pro Gly Lys Thr Leu Glu Trp Leu Thr 
1               5                   10                  


<210>  66
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  66

Arg Leu Ser Ile Thr Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr 
1               5                   10                  15      


Met Thr Asn Met Asp Pro Leu Asp Thr Gly Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  67

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  68
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  69
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  69

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  70
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  70

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  71
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  71

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  72
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  73
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  73

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Phe 
1               5                   10                  15  


<210>  74
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  74

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Leu Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  75
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  75

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  76
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  76

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  77
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  77

Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  78
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  78

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  79
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  79

Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys 
1               5                   10  


<210>  80
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  81
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  81

Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  82
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  82

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asp Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  83
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized framework sequence

<400>  83

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  84
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain amino acid sequences of humanized 13E2 monoclonal 
       antibody

<400>  84

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys 
            20                  25                  30          


Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Leu Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Thr Leu Glu Trp Leu Thr His Ile Trp Trp Asp Asp Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Asp Leu Arg Ser Arg Leu Ser Ile Thr Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Leu Asp Thr Gly 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Val Glu Gly Ser Tyr Ser Ser Ser Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys 
465                 


<210>  85
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain amino acid sequence of humanized 13E2 monoclonal 
       antibody

<400>  85

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ile Phe Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Val Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


