                         SEQUENCE LISTING

<110>  UTI Limited Partnership
 
<120>  MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9 
       EXPRESSION (PCSK9)

<130>  A8136974WO

<140>  N/A
<141>  2016-08-29

<150>  62/211,190
<151>  2015-08-28

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant HSP25 peptide

<400>  1

Cys Ala Thr Ala Thr Gly Cys Ala Thr Cys Ala Cys Cys Ala Thr Cys 
1               5                   10                  15      


Ala Thr Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Thr Gly Ala 
            20                  25                  30          


Thr Gly Ala Cys Gly Ala Cys Gly Ala Cys Ala Ala Gly Ala Cys Cys 
        35                  40                  45              


Gly Ala Gly Cys Gly Cys Cys Gly Cys Gly Thr Gly Cys Cys Cys Thr 
    50                  55                  60                  


Thr Cys Thr Cys Gly Cys Thr Gly Cys Thr Gly Cys Gly Gly Ala Gly 
65                  70                  75                  80  


Cys Cys Cys Gly Ala Gly Cys Thr Gly Gly Gly Ala Ala Cys Cys Ala 
                85                  90                  95      


Thr Thr Cys Cys Gly Gly Gly Ala Cys Thr Gly Gly Thr Ala Cys Cys 
            100                 105                 110         


Cys Thr Gly Cys Ala Cys Ala Cys Ala Gly Cys Cys Gly Cys Cys Thr 
        115                 120                 125             


Cys Thr Thr Cys Gly Ala Thr Cys Ala Ala Gly Cys Thr Thr Thr Cys 
    130                 135                 140                 


Gly Gly Gly Gly Thr Gly Cys Cys Cys Cys Gly Gly Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Cys Gly Ala Thr Gly Ala Gly Thr Gly Gly Thr Cys Gly Cys Ala 
                165                 170                 175     


Gly Thr Gly Gly Thr Thr Cys Ala Gly Cys Gly Cys Cys Gly Cys Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Gly Cys Cys Cys Gly Gly Ala Thr Ala Cys Gly 
        195                 200                 205             


Thr Gly Cys Gly Cys Cys Cys Gly Cys Thr Gly Cys Cys Cys Gly Cys 
    210                 215                 220                 


Cys Gly Cys Gly Ala Cys Cys Gly Cys Cys Gly Ala Gly Gly Gly Cys 
225                 230                 235                 240 


Cys Cys Cys Gly Cys Gly Gly Cys Gly Gly Thr Gly Ala Cys Cys Cys 
                245                 250                 255     


Thr Gly Gly Cys Cys Gly Cys Ala Cys Cys Ala Gly Cys Cys Thr Thr 
            260                 265                 270         


Cys Ala Gly Cys Cys Gly Ala Gly Cys Gly Cys Thr Cys Ala Ala Cys 
        275                 280                 285             


Cys Gly Ala Cys Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Gly 
    290                 295                 300                 


Gly Gly Gly Thr Cys Thr Cys Gly Gly Ala Gly Ala Thr Cys Cys Gly 
305                 310                 315                 320 


Ala Cys Ala Gly Ala Cys Gly Gly Cys Thr Gly Ala Thr Cys Gly Cys 
                325                 330                 335     


Thr Gly Gly Cys Gly Cys Gly Thr Gly Thr Cys Cys Cys Thr Gly Gly 
            340                 345                 350         


Ala Cys Gly Thr Cys Ala Ala Cys Cys Ala Cys Thr Thr Cys Gly Cys 
        355                 360                 365             


Thr Cys Cys Gly Gly Ala Gly Gly Ala Gly Cys Thr Cys Ala Cys Ala 
    370                 375                 380                 


Gly Thr Gly Ala Ala Gly Ala Cys Cys Ala Ala Gly Gly Ala Ala Gly 
385                 390                 395                 400 


Gly Cys Gly Thr Gly Gly Thr Gly Gly Ala Gly Ala Thr Cys Ala Cys 
                405                 410                 415     


Thr Gly Gly Cys Ala Ala Gly Cys Ala Cys Gly Ala Ala Gly Ala Ala 
            420                 425                 430         


Ala Gly Gly Cys Ala Gly Gly Ala Cys Gly Ala Ala Cys Ala Thr Gly 
        435                 440                 445             


Gly Cys Thr Ala Cys Ala Thr Cys Thr Cys Thr Cys Gly Gly Thr Gly 
    450                 455                 460                 


Cys Thr Thr Cys Ala Cys Cys Cys Gly Gly Ala Ala Ala Thr Ala Cys 
465                 470                 475                 480 


Ala Cys Gly Cys Thr Cys Cys Cys Thr Cys Cys Ala Gly Gly Thr Gly 
                485                 490                 495     


Thr Gly Gly Ala Cys Cys Cys Cys Ala Cys Cys Cys Thr Ala Gly Thr 
            500                 505                 510         


Gly Thr Cys Cys Thr Cys Thr Thr Cys Cys Cys Thr Ala Thr Cys Cys 
        515                 520                 525             


Cys Cys Thr Gly Ala Gly Gly Gly Cys Ala Cys Ala Cys Thr Thr Ala 
    530                 535                 540                 


Cys Cys Gly Thr Gly Gly Ala Gly Gly Cys Thr Cys Cys Gly Thr Thr 
545                 550                 555                 560 


Gly Cys Cys Cys Ala Ala Ala Gly Cys Ala Gly Thr Cys Ala Cys Gly 
                565                 570                 575     


Cys Ala Gly Thr Cys Ala Gly Cys Gly Gly Ala Gly Ala Thr Cys Ala 
            580                 585                 590         


Cys Cys Ala Thr Thr Cys Cys Gly Gly Thr Thr Ala Cys Thr Thr Thr 
        595                 600                 605             


Cys Gly Ala Gly Gly Cys Cys Cys Gly Cys Gly Cys Cys Cys Ala Ala 
    610                 615                 620                 


Ala Thr Thr Gly Gly Gly Gly Gly Cys Cys Cys Ala Gly Ala Ala Gly 
625                 630                 635                 640 


Cys Thr Gly Gly Gly Ala Ala Gly Thr Cys Thr Gly Ala Ala Cys Ala 
                645                 650                 655     


Gly Thr Cys Thr Gly Gly Ala Gly Cys Cys Ala Ala Gly Thr Ala Gly 
            660                 665                 670         


Gly Ala Ala Thr Thr Cys 
        675             


<210>  2
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant HSP27 peptide

<400>  2

Cys Ala Thr Ala Thr Gly Cys Ala Thr Cys Ala Cys Cys Ala Thr Cys 
1               5                   10                  15      


Ala Thr Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Thr Gly Ala 
            20                  25                  30          


Thr Gly Ala Cys Gly Ala Cys Gly Ala Cys Ala Ala Gly Ala Cys Cys 
        35                  40                  45              


Gly Ala Gly Cys Gly Cys Cys Gly Cys Gly Thr Cys Cys Cys Cys Thr 
    50                  55                  60                  


Thr Cys Thr Cys Gly Cys Thr Cys Cys Thr Gly Cys Gly Gly Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Cys Ala Gly Cys Thr Gly Gly Gly Ala Cys Cys Cys Cys 
                85                  90                  95      


Thr Thr Cys Cys Gly Cys Gly Ala Cys Thr Gly Gly Thr Ala Cys Cys 
            100                 105                 110         


Cys Gly Cys Ala Thr Ala Gly Cys Cys Gly Cys Cys Thr Cys Thr Thr 
        115                 120                 125             


Cys Gly Ala Cys Cys Ala Gly Gly Cys Cys Thr Thr Cys Gly Gly Gly 
    130                 135                 140                 


Cys Thr Gly Cys Cys Cys Cys Gly Gly Cys Thr Gly Cys Cys Gly Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Gly Thr Gly Gly Thr Cys Gly Cys Ala Gly Thr Gly 
                165                 170                 175     


Gly Thr Thr Ala Gly Gly Cys Gly Gly Cys Ala Gly Cys Ala Gly Cys 
            180                 185                 190         


Thr Gly Gly Cys Cys Ala Gly Gly Cys Thr Ala Cys Gly Thr Gly Cys 
        195                 200                 205             


Gly Cys Cys Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Gly Cys 
    210                 215                 220                 


Cys Gly Cys Cys Ala Thr Cys Gly Ala Gly Ala Gly Cys Cys Cys Cys 
225                 230                 235                 240 


Gly Cys Ala Gly Thr Gly Gly Cys Cys Gly Cys Gly Cys Cys Cys Gly 
                245                 250                 255     


Cys Cys Thr Ala Cys Ala Gly Cys Cys Gly Cys Gly Cys Gly Cys Thr 
            260                 265                 270         


Cys Ala Gly Cys Cys Gly Gly Cys Ala Ala Cys Thr Cys Ala Gly Cys 
        275                 280                 285             


Ala Gly Cys Gly Gly Gly Gly Thr Cys Thr Cys Gly Gly Ala Gly Ala 
    290                 295                 300                 


Thr Cys Cys Gly Gly Cys Ala Cys Ala Cys Thr Gly Cys Gly Gly Ala 
305                 310                 315                 320 


Cys Cys Gly Cys Thr Gly Gly Cys Gly Cys Gly Thr Gly Thr Cys Cys 
                325                 330                 335     


Cys Thr Gly Gly Ala Thr Gly Thr Cys Ala Ala Cys Cys Ala Cys Thr 
            340                 345                 350         


Thr Cys Gly Cys Cys Cys Cys Gly Gly Ala Cys Gly Ala Gly Cys Thr 
        355                 360                 365             


Gly Ala Cys Gly Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly 
    370                 375                 380                 


Gly Ala Thr Gly Gly Cys Gly Thr Gly Gly Thr Gly Gly Ala Gly Ala 
385                 390                 395                 400 


Thr Cys Ala Cys Cys Gly Gly Cys Ala Ala Gly Cys Ala Cys Gly Ala 
                405                 410                 415     


Gly Gly Ala Gly Cys Gly Gly Cys Ala Gly Gly Ala Cys Gly Ala Gly 
            420                 425                 430         


Cys Ala Thr Gly Gly Cys Thr Ala Cys Ala Thr Cys Thr Cys Cys Cys 
        435                 440                 445             


Gly Gly Thr Gly Cys Thr Thr Cys Ala Cys Gly Cys Gly Gly Ala Ala 
    450                 455                 460                 


Ala Thr Ala Cys Ala Cys Gly Cys Thr Gly Cys Cys Cys Cys Cys Cys 
465                 470                 475                 480 


Gly Gly Thr Gly Thr Gly Gly Ala Cys Cys Cys Cys Ala Cys Cys Cys 
                485                 490                 495     


Ala Ala Gly Thr Thr Thr Cys Cys Thr Cys Cys Thr Cys Cys Cys Thr 
            500                 505                 510         


Gly Thr Cys Cys Cys Cys Thr Gly Ala Gly Gly Gly Cys Ala Cys Ala 
        515                 520                 525             


Cys Thr Gly Ala Cys Cys Gly Thr Gly Gly Ala Gly Gly Cys Cys Cys 
    530                 535                 540                 


Cys Cys Ala Thr Gly Cys Cys Cys Ala Ala Gly Cys Thr Ala Gly Cys 
545                 550                 555                 560 


Cys Ala Cys Gly Cys Ala Gly Thr Cys Cys Ala Ala Cys Gly Ala Gly 
                565                 570                 575     


Ala Thr Cys Ala Cys Cys Ala Thr Cys Cys Cys Ala Gly Thr Cys Ala 
            580                 585                 590         


Cys Cys Thr Thr Cys Gly Ala Gly Thr Cys Gly Cys Gly Gly Gly Cys 
        595                 600                 605             


Cys Cys Ala Gly Cys Thr Thr Gly Gly Gly Gly Gly Cys Cys Cys Ala 
    610                 615                 620                 


Gly Ala Ala Gly Cys Thr Gly Cys Ala Ala Ala Ala Thr Cys Cys Gly 
625                 630                 635                 640 


Ala Thr Gly Ala Gly Ala Cys Thr Gly Cys Cys Gly Cys Cys Ala Ala 
                645                 650                 655     


Gly Thr Ala Ala Gly Ala Ala Thr Thr Cys 
            660                 665     


<210>  3
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3

Met His His His His His His His His Asp Asp Asp Asp Lys Met Thr 
1               5                   10                  15      


Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Ser Pro Ser Trp Glu Pro 
            20                  25                  30          


Phe Arg Asp Trp Tyr Pro Ala His Ser Arg Leu Phe Asp Gln Ala Phe 
        35                  40                  45              


Gly Val Pro Arg Leu Pro Asp Glu Trp Ser Gln Trp Phe Ser Ala Ala 
    50                  55                  60                  


Gly Trp Pro Gly Tyr Val Arg Pro Leu Pro Ala Ala Thr Ala Glu Gly 
65                  70                  75                  80  


Pro Ala Ala Val Thr Leu Ala Ala Pro Ala Phe Ser Arg Ala Leu Asn 
                85                  90                  95      


Arg Gln Leu Ser Ser Gly Val Ser Glu Ile Arg Gln Thr Ala Asp Arg 
            100                 105                 110         


Trp Arg Val Ser Leu Asp Val Asn His Phe Ala Pro Glu Glu Leu Thr 
        115                 120                 125             


Val Lys Thr Lys Glu Gly Val Val Glu Ile Thr Gly Lys His Glu Glu 
    130                 135                 140                 


Arg Gln Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr 
145                 150                 155                 160 


Thr Leu Pro Pro Gly Val Asp Pro Thr Leu Val Ser Ser Ser Leu Ser 
                165                 170                 175     


Pro Glu Gly Thr Leu Thr Val Glu Ala Pro Leu Pro Lys Ala Val Thr 
            180                 185                 190         


Gln Ser Ala Glu Ile Thr Ile Pro Val Thr Phe Glu Ala Arg Ala Gln 
        195                 200                 205             


Ile Gly Gly Pro Glu Ala Gly Lys Ser Glu Gln Ser Gly Ala Lys 
    210                 215                 220             


<210>  4
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His His His His His His His His Asp Asp Asp Asp Lys Met Thr 
1               5                   10                  15      


Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp Asp Pro 
            20                  25                  30          


Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala Phe Gly 
        35                  40                  45              


Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly Ser Ser 
    50                  55                  60                  


Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu Ser Pro 
65                  70                  75                  80  


Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln Leu Ser 
                85                  90                  95      


Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg Val Ser 
            100                 105                 110         


Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys Thr Lys 
        115                 120                 125             


Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln Asp Glu 
    130                 135                 140                 


His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu Gly Thr 
                165                 170                 175     


Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser Asn Glu 
            180                 185                 190         


Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly Gly Pro 
        195                 200                 205             


Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
    210                 215                 


<210>  5
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant truncated form of HSP27 protein consisting of the 
       biologically inactive C-terminus

<400>  5

Met His His His His His His His His Asp Asp Asp Asp Lys Gly Gly 
1               5                   10                  15      


Asp Arg Trp Arg Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu 
            20                  25                  30          


Leu Thr Val Lys Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His 
        35                  40                  45              


Glu Glu Arg Gln Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg 
    50                  55                  60                  


Lys Tyr Thr Leu Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Glu Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu 
                85                  90                  95      


Ser Thr Gln Ser Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg 
            100                 105                 110         


Ala Gln Leu Gly Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala 
        115                 120                 125             


Lys 
    


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signature peptide for HSP27

<400>  6

Leu Phe Asp Gln Ala Phe Gly Leu Pro Arg 
1               5                   10  


