                         SEQUENCE LISTING

<110>  Raskatov, Jevgenij A.
 
<120>  Chiral Conversion of Amyloid Proteins Associated with Diseases

<130>  482.44-1PCT

<150>  US 62/210,757
<151>  2015-08-27

<150>  US 62/365,841
<151>  2016-07-22

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu 
    


<210>  2
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  3
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  4
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


<210>  5
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  6
<211>  3145
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala 
                85                  90                  95      


Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile 
            100                 105                 110         


Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly 
        115                 120                 125             


Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp 
    130                 135                 140                 


Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu 
145                 150                 155                 160 


Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile 
                165                 170                 175     


Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe 
            180                 185                 190         


Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu 
        195                 200                 205             


Val Asn Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu 
    210                 215                 220                 


Ser Val Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser 
225                 230                 235                 240 


Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala 
                245                 250                 255     


Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala 
            260                 265                 270         


Ala Gly Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr 
        275                 280                 285             


Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val 
    290                 295                 300                 


Glu Asp Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu 
305                 310                 315                 320 


Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu 
                325                 330                 335     


Lys Gly Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser 
            340                 345                 350         


Ala Glu Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln 
        355                 360                 365             


His Gln Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln 
    370                 375                 380                 


Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val 
385                 390                 395                 400 


Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg 
                405                 410                 415     


Ser Arg Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser 
            420                 425                 430         


Cys Ser Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly 
        435                 440                 445             


Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser 
    450                 455                 460                 


Ser Ser Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile 
                485                 490                 495     


Ile Thr Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val 
            500                 505                 510         


Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu 
        515                 520                 525             


Glu Asp Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser 
    530                 535                 540                 


Asp Pro Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile 
545                 550                 555                 560 


Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr 
                565                 570                 575     


Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr 
            580                 585                 590         


Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr 
        595                 600                 605             


Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met 
    610                 615                 620                 


Ala Leu Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln 
625                 630                 635                 640 


Pro Ser Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr 
                645                 650                 655     


Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile 
            660                 665                 670         


Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg 
        675                 680                 685             


Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val 
    690                 695                 700                 


Pro Asp Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys 
705                 710                 715                 720 


Val Gly Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu 
                725                 730                 735     


Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val 
            740                 745                 750         


Ser Asp Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly 
        755                 760                 765             


Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg 
    770                 775                 780                 


Ser Arg Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr 
785                 790                 795                 800 


Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr 
                805                 810                 815     


Leu Lys Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val 
            820                 825                 830         


Arg Asn Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly 
        835                 840                 845             


Leu Gln Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp 
    850                 855                 860                 


Leu Val Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg 
865                 870                 875                 880 


Leu Val Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala 
                885                 890                 895     


His His Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn 
            900                 905                 910         


Val Val Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val 
        915                 920                 925             


Ala Ala Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys 
    930                 935                 940                 


Asp Gln Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser 
945                 950                 955                 960 


Ser Val Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His 
                965                 970                 975     


Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu 
            980                 985                 990         


Pro Ser Ile Thr Asp Val Thr Met  Glu Asn Asn Leu Ser  Arg Val Ile 
        995                 1000                 1005             


Ala Ala  Val Ser His Glu Leu  Ile Thr Ser Thr Thr  Arg Ala Leu 
    1010                 1015                 1020             


Thr Phe  Gly Cys Cys Glu Ala  Leu Cys Leu Leu Ser  Thr Ala Phe 
    1025                 1030                 1035             


Pro Val  Cys Ile Trp Ser Leu  Gly Trp His Cys Gly  Val Pro Pro 
    1040                 1045                 1050             


Leu Ser  Ala Ser Asp Glu Ser  Arg Lys Ser Cys Thr  Val Gly Met 
    1055                 1060                 1065             


Ala Thr  Met Ile Leu Thr Leu  Leu Ser Ser Ala Trp  Phe Pro Leu 
    1070                 1075                 1080             


Asp Leu  Ser Ala His Gln Asp  Ala Leu Ile Leu Ala  Gly Asn Leu 
    1085                 1090                 1095             


Leu Ala  Ala Ser Ala Pro Lys  Ser Leu Arg Ser Ser  Trp Ala Ser 
    1100                 1105                 1110             


Glu Glu  Glu Ala Asn Pro Ala  Ala Thr Lys Gln Glu  Glu Val Trp 
    1115                 1120                 1125             


Pro Ala  Leu Gly Asp Arg Ala  Leu Val Pro Met Val  Glu Gln Leu 
    1130                 1135                 1140             


Phe Ser  His Leu Leu Lys Val  Ile Asn Ile Cys Ala  His Val Leu 
    1145                 1150                 1155             


Asp Asp  Val Ala Pro Gly Pro  Ala Ile Lys Ala Ala  Leu Pro Ser 
    1160                 1165                 1170             


Leu Thr  Asn Pro Pro Ser Leu  Ser Pro Ile Arg Arg  Lys Gly Lys 
    1175                 1180                 1185             


Glu Lys  Glu Pro Gly Glu Gln  Ala Ser Val Pro Leu  Ser Pro Lys 
    1190                 1195                 1200             


Lys Gly  Ser Glu Ala Ser Ala  Ala Ser Arg Gln Ser  Asp Thr Ser 
    1205                 1210                 1215             


Gly Pro  Val Thr Thr Ser Lys  Ser Ser Ser Leu Gly  Ser Phe Tyr 
    1220                 1225                 1230             


His Leu  Pro Ser Tyr Leu Lys  Leu His Asp Val Leu  Lys Ala Thr 
    1235                 1240                 1245             


His Ala  Asn Tyr Lys Val Thr  Leu Asp Leu Gln Asn  Ser Thr Glu 
    1250                 1255                 1260             


Lys Phe  Gly Gly Phe Leu Arg  Ser Ala Leu Asp Val  Leu Ser Gln 
    1265                 1270                 1275             


Ile Leu  Glu Leu Ala Thr Leu  Gln Asp Ile Gly Lys  Cys Val Glu 
    1280                 1285                 1290             


Glu Ile  Leu Gly Tyr Leu Lys  Ser Cys Phe Ser Arg  Glu Pro Met 
    1295                 1300                 1305             


Met Ala  Thr Val Cys Val Gln  Gln Leu Leu Lys Thr  Leu Phe Gly 
    1310                 1315                 1320             


Thr Asn  Leu Ala Ser Gln Phe  Asp Gly Leu Ser Ser  Asn Pro Ser 
    1325                 1330                 1335             


Lys Ser  Gln Gly Arg Ala Gln  Arg Leu Gly Ser Ser  Ser Val Arg 
    1340                 1345                 1350             


Pro Gly  Leu Tyr His Tyr Cys  Phe Met Ala Pro Tyr  Thr His Phe 
    1355                 1360                 1365             


Thr Gln  Ala Leu Ala Asp Ala  Ser Leu Arg Asn Met  Val Gln Ala 
    1370                 1375                 1380             


Glu Gln  Glu Asn Asp Thr Ser  Gly Trp Phe Asp Val  Leu Gln Lys 
    1385                 1390                 1395             


Val Ser  Thr Gln Leu Lys Thr  Asn Leu Thr Ser Val  Thr Lys Asn 
    1400                 1405                 1410             


Arg Ala  Asp Lys Asn Ala Ile  His Asn His Ile Arg  Leu Phe Glu 
    1415                 1420                 1425             


Pro Leu  Val Ile Lys Ala Leu  Lys Gln Tyr Thr Thr  Thr Thr Cys 
    1430                 1435                 1440             


Val Gln  Leu Gln Lys Gln Val  Leu Asp Leu Leu Ala  Gln Leu Val 
    1445                 1450                 1455             


Gln Leu  Arg Val Asn Tyr Cys  Leu Leu Asp Ser Asp  Gln Val Phe 
    1460                 1465                 1470             


Ile Gly  Phe Val Leu Lys Gln  Phe Glu Tyr Ile Glu  Val Gly Gln 
    1475                 1480                 1485             


Phe Arg  Glu Ser Glu Ala Ile  Ile Pro Asn Ile Phe  Phe Phe Leu 
    1490                 1495                 1500             


Val Leu  Leu Ser Tyr Glu Arg  Tyr His Ser Lys Gln  Ile Ile Gly 
    1505                 1510                 1515             


Ile Pro  Lys Ile Ile Gln Leu  Cys Asp Gly Ile Met  Ala Ser Gly 
    1520                 1525                 1530             


Arg Lys  Ala Val Thr His Ala  Ile Pro Ala Leu Gln  Pro Ile Val 
    1535                 1540                 1545             


His Asp  Leu Phe Val Leu Arg  Gly Thr Asn Lys Ala  Asp Ala Gly 
    1550                 1555                 1560             


Lys Glu  Leu Glu Thr Gln Lys  Glu Val Val Val Ser  Met Leu Leu 
    1565                 1570                 1575             


Arg Leu  Ile Gln Tyr His Gln  Val Leu Glu Met Phe  Ile Leu Val 
    1580                 1585                 1590             


Leu Gln  Gln Cys His Lys Glu  Asn Glu Asp Lys Trp  Lys Arg Leu 
    1595                 1600                 1605             


Ser Arg  Gln Ile Ala Asp Ile  Ile Leu Pro Met Leu  Ala Lys Gln 
    1610                 1615                 1620             


Gln Met  His Ile Asp Ser His  Glu Ala Leu Gly Val  Leu Asn Thr 
    1625                 1630                 1635             


Leu Phe  Glu Ile Leu Ala Pro  Ser Ser Leu Arg Pro  Val Asp Met 
    1640                 1645                 1650             


Leu Leu  Arg Ser Met Phe Val  Thr Pro Asn Thr Met  Ala Ser Val 
    1655                 1660                 1665             


Ser Thr  Val Gln Leu Trp Ile  Ser Gly Ile Leu Ala  Ile Leu Arg 
    1670                 1675                 1680             


Val Leu  Ile Ser Gln Ser Thr  Glu Asp Ile Val Leu  Ser Arg Ile 
    1685                 1690                 1695             


Gln Glu  Leu Ser Phe Ser Pro  Tyr Leu Ile Ser Cys  Thr Val Ile 
    1700                 1705                 1710             


Asn Arg  Leu Arg Asp Gly Asp  Ser Thr Ser Thr Leu  Glu Glu His 
    1715                 1720                 1725             


Ser Glu  Gly Lys Gln Ile Lys  Asn Leu Pro Glu Glu  Thr Phe Ser 
    1730                 1735                 1740             


Arg Phe  Leu Leu Gln Leu Val  Gly Ile Leu Leu Glu  Asp Ile Val 
    1745                 1750                 1755             


Thr Lys  Gln Leu Lys Val Glu  Met Ser Glu Gln Gln  His Thr Phe 
    1760                 1765                 1770             


Tyr Cys  Gln Glu Leu Gly Thr  Leu Leu Met Cys Leu  Ile His Ile 
    1775                 1780                 1785             


Phe Lys  Ser Gly Met Phe Arg  Arg Ile Thr Ala Ala  Ala Thr Arg 
    1790                 1795                 1800             


Leu Phe  Arg Ser Asp Gly Cys  Gly Gly Ser Phe Tyr  Thr Leu Asp 
    1805                 1810                 1815             


Ser Leu  Asn Leu Arg Ala Arg  Ser Met Ile Thr Thr  His Pro Ala 
    1820                 1825                 1830             


Leu Val  Leu Leu Trp Cys Gln  Ile Leu Leu Leu Val  Asn His Thr 
    1835                 1840                 1845             


Asp Tyr  Arg Trp Trp Ala Glu  Val Gln Gln Thr Pro  Lys Arg His 
    1850                 1855                 1860             


Ser Leu  Ser Ser Phe Thr Lys  Leu Leu Ser Pro Gln  Met Ser Gly 
    1865                 1870                 1875             


Glu Glu  Glu Asp Ser Asp Leu  Ala Ala Lys Leu Gly  Met Cys Asn 
    1880                 1885                 1890             


Arg Glu  Ile Val Arg Arg Gly  Ala Leu Ile Leu Phe  Cys Asp Tyr 
    1895                 1900                 1905             


Val Cys  Gln Asn Leu His Asp  Ser Glu His Leu Thr  Trp Leu Ile 
    1910                 1915                 1920             


Val Asn  His Ile Gln Asp Leu  Ile Ser Leu Ser His  Glu Pro Pro 
    1925                 1930                 1935             


Val Gln  Asp Phe Ile Ser Ala  Val His Arg Asn Ser  Ala Ala Ser 
    1940                 1945                 1950             


Gly Leu  Phe Ile Gln Ala Ile  Gln Ser Arg Cys Glu  Asn Leu Ser 
    1955                 1960                 1965             


Thr Pro  Thr Met Leu Lys Lys  Thr Leu Gln Cys Leu  Glu Gly Ile 
    1970                 1975                 1980             


His Leu  Ser Gln Ser Gly Ala  Val Leu Thr Leu Tyr  Val Asp Arg 
    1985                 1990                 1995             


Leu Leu  Cys Thr Pro Phe Arg  Val Leu Ala Arg Met  Val Asp Ile 
    2000                 2005                 2010             


Leu Ala  Cys Arg Arg Val Glu  Met Leu Leu Ala Ala  Asn Leu Gln 
    2015                 2020                 2025             


Ser Ser  Met Ala Gln Leu Pro  Met Glu Glu Leu Asn  Arg Ile Gln 
    2030                 2035                 2040             


Glu Tyr  Leu Gln Ser Ser Gly  Leu Ala Gln Arg His  Gln Arg Leu 
    2045                 2050                 2055             


Tyr Ser  Leu Leu Asp Arg Phe  Arg Leu Ser Thr Met  Gln Asp Ser 
    2060                 2065                 2070             


Leu Ser  Pro Ser Pro Pro Val  Ser Ser His Pro Leu  Asp Gly Asp 
    2075                 2080                 2085             


Gly His  Val Ser Leu Glu Thr  Val Ser Pro Asp Lys  Asp Trp Tyr 
    2090                 2095                 2100             


Val His  Leu Val Lys Ser Gln  Cys Trp Thr Arg Ser  Asp Ser Ala 
    2105                 2110                 2115             


Leu Leu  Glu Gly Ala Glu Leu  Val Asn Arg Ile Pro  Ala Glu Asp 
    2120                 2125                 2130             


Met Asn  Ala Phe Met Met Asn  Ser Glu Phe Asn Leu  Ser Leu Leu 
    2135                 2140                 2145             


Ala Pro  Cys Leu Ser Leu Gly  Met Ser Glu Ile Ser  Gly Gly Gln 
    2150                 2155                 2160             


Lys Ser  Ala Leu Phe Glu Ala  Ala Arg Glu Val Thr  Leu Ala Arg 
    2165                 2170                 2175             


Val Ser  Gly Thr Val Gln Gln  Leu Pro Ala Val His  His Val Phe 
    2180                 2185                 2190             


Gln Pro  Glu Leu Pro Ala Glu  Pro Ala Ala Tyr Trp  Ser Lys Leu 
    2195                 2200                 2205             


Asn Asp  Leu Phe Gly Asp Ala  Ala Leu Tyr Gln Ser  Leu Pro Thr 
    2210                 2215                 2220             


Leu Ala  Arg Ala Leu Ala Gln  Tyr Leu Val Val Val  Ser Lys Leu 
    2225                 2230                 2235             


Pro Ser  His Leu His Leu Pro  Pro Glu Lys Glu Lys  Asp Ile Val 
    2240                 2245                 2250             


Lys Phe  Val Val Ala Thr Leu  Glu Ala Leu Ser Trp  His Leu Ile 
    2255                 2260                 2265             


His Glu  Gln Ile Pro Leu Ser  Leu Asp Leu Gln Ala  Gly Leu Asp 
    2270                 2275                 2280             


Cys Cys  Cys Leu Ala Leu Gln  Leu Pro Gly Leu Trp  Ser Val Val 
    2285                 2290                 2295             


Ser Ser  Thr Glu Phe Val Thr  His Ala Cys Ser Leu  Ile Tyr Cys 
    2300                 2305                 2310             


Val His  Phe Ile Leu Glu Ala  Val Ala Val Gln Pro  Gly Glu Gln 
    2315                 2320                 2325             


Leu Leu  Ser Pro Glu Arg Arg  Thr Asn Thr Pro Lys  Ala Ile Ser 
    2330                 2335                 2340             


Glu Glu  Glu Glu Glu Val Asp  Pro Asn Thr Gln Asn  Pro Lys Tyr 
    2345                 2350                 2355             


Ile Thr  Ala Ala Cys Glu Met  Val Ala Glu Met Val  Glu Ser Leu 
    2360                 2365                 2370             


Gln Ser  Val Leu Ala Leu Gly  His Lys Arg Asn Ser  Gly Val Pro 
    2375                 2380                 2385             


Ala Phe  Leu Thr Pro Leu Leu  Arg Asn Ile Ile Ile  Ser Leu Ala 
    2390                 2395                 2400             


Arg Leu  Pro Leu Val Asn Ser  Tyr Thr Arg Val Pro  Pro Leu Val 
    2405                 2410                 2415             


Trp Lys  Leu Gly Trp Ser Pro  Lys Pro Gly Gly Asp  Phe Gly Thr 
    2420                 2425                 2430             


Ala Phe  Pro Glu Ile Pro Val  Glu Phe Leu Gln Glu  Lys Glu Val 
    2435                 2440                 2445             


Phe Lys  Glu Phe Ile Tyr Arg  Ile Asn Thr Leu Gly  Trp Thr Ser 
    2450                 2455                 2460             


Arg Thr  Gln Phe Glu Glu Thr  Trp Ala Thr Leu Leu  Gly Val Leu 
    2465                 2470                 2475             


Val Thr  Gln Pro Leu Val Met  Glu Gln Glu Glu Ser  Pro Pro Glu 
    2480                 2485                 2490             


Glu Asp  Thr Glu Arg Thr Gln  Ile Asn Val Leu Ala  Val Gln Ala 
    2495                 2500                 2505             


Ile Thr  Ser Leu Val Leu Ser  Ala Met Thr Val Pro  Val Ala Gly 
    2510                 2515                 2520             


Asn Pro  Ala Val Ser Cys Leu  Glu Gln Gln Pro Arg  Asn Lys Pro 
    2525                 2530                 2535             


Leu Lys  Ala Leu Asp Thr Arg  Phe Gly Arg Lys Leu  Ser Ile Ile 
    2540                 2545                 2550             


Arg Gly  Ile Val Glu Gln Glu  Ile Gln Ala Met Val  Ser Lys Arg 
    2555                 2560                 2565             


Glu Asn  Ile Ala Thr His His  Leu Tyr Gln Ala Trp  Asp Pro Val 
    2570                 2575                 2580             


Pro Ser  Leu Ser Pro Ala Thr  Thr Gly Ala Leu Ile  Ser His Glu 
    2585                 2590                 2595             


Lys Leu  Leu Leu Gln Ile Asn  Pro Glu Arg Glu Leu  Gly Ser Met 
    2600                 2605                 2610             


Ser Tyr  Lys Leu Gly Gln Val  Ser Ile His Ser Val  Trp Leu Gly 
    2615                 2620                 2625             


Asn Ser  Ile Thr Pro Leu Arg  Glu Glu Glu Trp Asp  Glu Glu Glu 
    2630                 2635                 2640             


Glu Glu  Glu Ala Asp Ala Pro  Ala Pro Ser Ser Pro  Pro Thr Ser 
    2645                 2650                 2655             


Pro Val  Asn Ser Arg Lys His  Arg Ala Gly Val Asp  Ile His Ser 
    2660                 2665                 2670             


Cys Ser  Gln Phe Leu Leu Glu  Leu Tyr Ser Arg Trp  Ile Leu Pro 
    2675                 2680                 2685             


Ser Ser  Ser Ala Arg Arg Thr  Pro Ala Ile Leu Ile  Ser Glu Val 
    2690                 2695                 2700             


Val Arg  Ser Leu Leu Val Val  Ser Asp Leu Phe Thr  Glu Arg Asn 
    2705                 2710                 2715             


Gln Phe  Glu Leu Met Tyr Val  Thr Leu Thr Glu Leu  Arg Arg Val 
    2720                 2725                 2730             


His Pro  Ser Glu Asp Glu Ile  Leu Ala Gln Tyr Leu  Val Pro Ala 
    2735                 2740                 2745             


Thr Cys  Lys Ala Ala Ala Val  Leu Gly Met Asp Lys  Ala Val Ala 
    2750                 2755                 2760             


Glu Pro  Val Ser Arg Leu Leu  Glu Ser Thr Leu Arg  Ser Ser His 
    2765                 2770                 2775             


Leu Pro  Ser Arg Val Gly Ala  Leu His Gly Val Leu  Tyr Val Leu 
    2780                 2785                 2790             


Glu Cys  Asp Leu Leu Asp Asp  Thr Ala Lys Gln Leu  Ile Pro Val 
    2795                 2800                 2805             


Ile Ser  Asp Tyr Leu Leu Ser  Asn Leu Lys Gly Ile  Ala His Cys 
    2810                 2815                 2820             


Val Asn  Ile His Ser Gln Gln  His Val Leu Val Met  Cys Ala Thr 
    2825                 2830                 2835             


Ala Phe  Tyr Leu Ile Glu Asn  Tyr Pro Leu Asp Val  Gly Pro Glu 
    2840                 2845                 2850             


Phe Ser  Ala Ser Ile Ile Gln  Met Cys Gly Val Met  Leu Ser Gly 
    2855                 2860                 2865             


Ser Glu  Glu Ser Thr Pro Ser  Ile Ile Tyr His Cys  Ala Leu Arg 
    2870                 2875                 2880             


Gly Leu  Glu Arg Leu Leu Leu  Ser Glu Gln Leu Ser  Arg Leu Asp 
    2885                 2890                 2895             


Ala Glu  Ser Leu Val Lys Leu  Ser Val Asp Arg Val  Asn Val His 
    2900                 2905                 2910             


Ser Pro  His Arg Ala Met Ala  Ala Leu Gly Leu Met  Leu Thr Cys 
    2915                 2920                 2925             


Met Tyr  Thr Gly Lys Glu Lys  Val Ser Pro Gly Arg  Thr Ser Asp 
    2930                 2935                 2940             


Pro Asn  Pro Ala Ala Pro Asp  Ser Glu Ser Val Ile  Val Ala Met 
    2945                 2950                 2955             


Glu Arg  Val Ser Val Leu Phe  Asp Arg Ile Arg Lys  Gly Phe Pro 
    2960                 2965                 2970             


Cys Glu  Ala Arg Val Val Ala  Arg Ile Leu Pro Gln  Phe Leu Asp 
    2975                 2980                 2985             


Asp Phe  Phe Pro Pro Gln Asp  Ile Met Asn Lys Val  Ile Gly Glu 
    2990                 2995                 3000             


Phe Leu  Ser Asn Gln Gln Pro  Tyr Pro Gln Phe Met  Ala Thr Val 
    3005                 3010                 3015             


Val Tyr  Lys Val Phe Gln Thr  Leu His Ser Thr Gly  Gln Ser Ser 
    3020                 3025                 3030             


Met Val  Arg Asp Trp Val Met  Leu Ser Leu Ser Asn  Phe Thr Gln 
    3035                 3040                 3045             


Arg Ala  Pro Val Ala Met Ala  Thr Trp Ser Leu Ser  Cys Phe Phe 
    3050                 3055                 3060             


Val Ser  Ala Ser Thr Ser Pro  Trp Val Ala Ala Ile  Leu Pro His 
    3065                 3070                 3075             


Val Ile  Ser Arg Met Gly Lys  Leu Glu Gln Val Asp  Val Asn Leu 
    3080                 3085                 3090             


Phe Cys  Leu Val Ala Thr Asp  Phe Tyr Arg His Gln  Ile Glu Glu 
    3095                 3100                 3105             


Glu Leu  Asp Arg Arg Ala Phe  Gln Ser Val Leu Glu  Val Val Ala 
    3110                 3115                 3120             


Ala Pro  Gly Ser Pro Tyr His  Arg Leu Leu Thr Cys  Leu Arg Asn 
    3125                 3130                 3135             


Val His  Lys Val Thr Thr Cys  
    3140                 3145 


<210>  7
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala 
                85                  90                  95      


Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile 
            100                 105                 110         


Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly 
        115                 120                 125             


Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp 
    130                 135                 140                 


Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu 
145                 150                 155                 160 


Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile 
                165                 170                 175     


Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe 
            180                 185                 190         


Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu 
        195                 200                 205             


Val Asn Leu Leu Pro Cys Leu Thr Arg Thr 
    210                 215             


<210>  8
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Glu Glu Glu Phe Val 
    50                  55                  60                  


Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys Ala 
65                  70                  75                  80  


Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr Ala 
                85                  90                  95      


Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser Pro 
            100                 105                 110         


Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125     


<210>  9
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His Ala Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


