
                                SEQUENCE LISTING

<110> Hakonarson, Hakon
      Kao, Charlly
      Cardinale, Christopher
      Pandey, Rahul
      Li, Yun

<120> Methods of Treating Autoimmune
  Conditions in Patients with Genetic Variations in DcR3 or in
  a DcR3 Network Gene

<130> 3460-P06282WO00

<140> PCT/US2016/047872          
<141> 2016-08-19  

<150> 62/208,383          
<151> 2015-08-21  

<150> 62/320,400          
<151> 2016-04-08  

<160> 87

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 300
<212> PRT
<213> Homo Sapiens

<400> 1
Met Arg Ala Leu Glu Gly Pro Gly Leu Ser Leu Leu Cys Leu Val Leu
 1               5                  10                  15      
Ala Leu Pro Ala Leu Leu Pro Val Pro Ala Val Arg Gly Val Ala Glu
            20                  25                  30          
Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu Arg Leu Val
        35                  40                  45              
Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro Cys Arg Arg
    50                  55                  60                  
Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His Tyr Thr Gln
65                  70                  75                  80  
Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu Cys Gly
                85                  90                  95      
Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn Arg Ala
            100                 105                 110         
Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys Leu Glu
        115                 120                 125             
His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly Thr Pro
    130                 135                 140                 
Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe Ser Ala
145                 150                 155                 160 
Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys Thr Ala
                165                 170                 175     
Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp Thr Leu
            180                 185                 190         
Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro Gly Ala
        195                 200                 205             
Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln Asp Ile
    210                 215                 220                 
Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala Pro Glu
225                 230                 235                 240 
Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln Leu Lys
                245                 250                 255     
Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly Ala Leu
            260                 265                 270         
Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu
        275                 280                 285             
Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His
    290                 295                 300 


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain (HC) CDR1 antibody F19

<400> 2
Gly Tyr Asn Trp His
 1               5  


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 antibody F19

<400> 3
Glu Ile Thr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 antibody F19

<400> 4
Glu Ile Ala Val Ala Gly Thr Gly Tyr Tyr Gly Met Asp Val
 1               5                  10                  


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 antibody F19

<400> 5
Arg Ala Ser Gln Gly Ile Asn Ser Ala Phe Ala
 1               5                  10      


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 antibody F19

<400> 6
Asp Ala Ser Ser Leu Glu Ser
 1               5          


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 antibody F19

<400> 7
Gln Gln Phe Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 8
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region antibody F19

<400> 8
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Thr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val
                85                  90                  95      
Arg Glu Ile Ala Val Ala Gly Thr Gly Tyr Tyr Gly Met Asp Val Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly
        435                 440                 445             


<210> 9
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region antibody F19

<400> 9
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Ser Ala
            20                  25                  30          
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody F19

<400> 10
Arg Ala Ser Arg Gly Ile Asn Ser Ala Phe Ala
 1               5                  10      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody F19

<400> 11
Asp Ala Ser Ser Leu Glu Ser
 1               5          


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody F19

<400> 12
Gln Gln Phe Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody F19

<400> 13
Arg Val Ser Gln Gly Ile Ser Ser Tyr Leu Asn
 1               5                  10      


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody F19

<400> 14
Ser Ala Ser Asn Leu Gln Ser
 1               5          


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody F19

<400> 15
Ala Arg Thr Asn Ala Pro Pro Thr
 1               5              


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody F19

<400> 16
Arg Met Ser Gln Gly Ile Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody F19

<400> 17
Ala Ala Ser Thr Leu Gln Ser
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody F19

<400> 18
Gln Gln Tyr Tyr Ser Phe Pro Tyr Thr
 1               5                  


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody F19

<400> 19
Arg Ala Ser Gln Gly Val Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody F19

<400> 20
Asp Ala Ser Asn Arg Ala Thr
 1               5          


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody F19

<400> 21
Gln Gln Arg Ser Asn Trp His Pro
 1               5              


<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 antibody E1

<400> 22
Arg Phe Asn Met Asn
 1               5  


<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 antibody E1

<400> 23
Tyr Ile Ser Ser Ser Ser Tyr Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 antibody E1

<400> 24
Ser Ile Ala Ala Phe Asp Tyr
 1               5          


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 antibody E1

<400> 25
Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala
 1               5                  10      


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 antibody E1

<400> 26
Asp Ala Ser Ser Leu Glu Ser
 1               5          


<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 antibody E1

<400> 27
Gln Gln Phe Asn Ser Tyr Arg Thr
 1               5              


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody E1

<400> 28
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Thr
 1               5                  10          


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody E1

<400> 29
Gly Ala Ser Ser Arg Ala Thr
 1               5          


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody E1

<400> 30
Gln Gln Tyr Gly Ser Ser Met Tyr Thr
 1               5                  


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR1 antibody E1

<400> 31
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala
 1               5                  10          


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR2 antibody E1

<400> 32
Gly Ala Ser Asn Arg Ala Thr
 1               5          


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alternative LC CDR3 antibody E1

<400> 33
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
 1               5                  


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 antibody E13

<400> 34
Asn Ala Trp Met Ser
 1               5  


<210> 35
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 antibody E13

<400> 35
Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15      
Val Lys Gly
            


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 antibody E13

<400> 36
Ala Met Ala Gly Ala Phe Gly Phe
 1               5              


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 antibody E13

<400> 37
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala
 1               5                  10          


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 antibody E13

<400> 38
Gly Ala Ser Ser Arg Ala Thr
 1               5          


<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 antibody E13

<400> 39
Gln Gln Tyr Gly Ser Ser Pro Met Tyr Thr
 1               5                  10  


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 antibody E63

<400> 40
Ser Gly Gly Tyr Tyr Trp Ser
 1               5          


<210> 41
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 antibody E63

<400> 41
Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 antibody E63

<400> 42
Trp Ile Thr Met Phe Arg Gly Val Gly Phe Asp Pro
 1               5                  10          


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 antibody E63

<400> 43
Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His
 1               5                  10      


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 antibody E63

<400> 44
Tyr Ala Ser Gln Ser Phe Ser
 1               5          


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 antibody E63

<400> 45
Arg Gln Ser Ser Ser Leu Pro Leu Thr
 1               5                  


<210> 46
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 antibody F23

<400> 46
Gly Tyr Tyr Trp Asn
 1               5  


<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 antibody F23

<400> 47
Glu Ile Asn Gln Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10      


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 antibody F23

<400> 48
Glu Ile Ala Ile Ala Asp Lys Gly Tyr Tyr Gly Leu Asp Val
 1               5                  10                  


<210> 49
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 antibody F23

<400> 49
Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala
 1               5                  10      


<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 antibody F23

<400> 50
Asp Ala Ser Ser Leu Glu Ser
 1               5          


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 antibody F23

<400> 51
Gln Gln Phe Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1

<400> 52
Ser Tyr Tyr Ile His
 1               5  


<210> 53
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2

<400> 53
Pro Gly Ser Asp Ile Thr Lys Tyr Asn Glu Lys Phe Lys Gly
 1               5                  10                  


<210> 54
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3

<400> 54
Gly Ile Ser Thr Tyr Ser Ala Met Asp Phe
 1               5                  10  


<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1

<400> 55
Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala
 1               5                  10      


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2

<400> 56
Trp Ala Ser Thr Arg His Thr
 1               5          


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3

<400> 57
Gln Gln Tyr Ser Ser Tyr Pro Leu Thr
 1               5                  


<210> 58
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Phe Pro Gly Ser Asp Ile Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Asp Tyr Gly Ile Ser Thr Tyr Ser Ala Met Asp Phe Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 59
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 59
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 of 18E04

<400> 60
His Phe Asp Ile Asn
 1               5  


<210> 61
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 of 18E04

<400> 61
Trp Met Asn Pro Asp Ser Asp Asn Thr Asp Tyr Ala Gln Glu Phe Gln
 1               5                  10                  15      
Gly
    


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 of 18E04

<400> 62
Gly Gly Thr Thr Leu Asp Tyr
 1               5          


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 of 18E04

<400> 63
Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala Tyr
 1               5                  10      


<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 of 18E04

<400> 64
Glu Asp Ser Lys Arg Pro Ser
 1               5          


<210> 65
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 of 18E04

<400> 65
Tyr Ser Thr Asp Ser Ser Asp Asn His Val Ile
 1               5                  10      


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 of 98C07

<400> 66
Asp Tyr Tyr Met Ser
 1               5  


<210> 67
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 of 98C07

<400> 67
Tyr Ile Ser Arg Ser Ser Phe Ile Tyr Tyr Ser Glu Ser Val Lys Gly
 1               5                  10                  15      


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 of 98C07

<400> 68
Trp Glu Leu Ser Pro Phe Asp Tyr
 1               5              


<210> 69
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 of 98C07

<400> 69
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala
 1               5                  10      


<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 of 98C07

<400> 70
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 71
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 of 98C07

<400> 71
Gln Gln Tyr Asn Thr Tyr Pro Phe Thr
 1               5                  


<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 of 1C02

<400> 72
Tyr Tyr Gly Ile Ser
 1               5  


<210> 73
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 of 1C02

<400> 73
Trp Ile Ser Ala Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 of 1C02

<400> 74
Gly Gly Val Ala Val Leu Glu Tyr
 1               5              


<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 of 1C02

<400> 75
Trp Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 of 1C02

<400> 76
Val Ala Ser Thr Leu Gln Ser
 1               5          


<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 of 1C02

<400> 77
Gln Gln Leu Lys Ile Tyr Pro Leu Thr
 1               5                  


<210> 78
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR1 of 1C06

<400> 78
Asp Tyr Tyr Met Asn
 1               5  


<210> 79
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR2 of 1C06

<400> 79
Asp Ile Ser Ser Arg Asp Asn Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 80
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC CDR3 of 1C06

<400> 80
Ala Arg Glu Arg Gly Phe Gly Asp Tyr Phe Gly Met Asp Val
 1               5                  10                  


<210> 81
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR1 of 1C06

<400> 81
Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala
 1               5                  10      


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR2 of 1C06

<400> 82
Asp Ala Ser Ser Leu Glu Ser
 1               5          


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC CDR3 of 1C06

<400> 83
Gln Gln Phe Asn Thr Tyr Pro Leu Thr
 1               5                  


<210> 84
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> DcR3 siRNA sense strand

<400> 84
gccaggcucu uccucccaut t                                           21

<210> 85
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> DcR3 siRNA antisense strand

<400> 85
augggaggaa gagccuggct t                                           21

<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> control siRNA sense strand

<400> 86
gcccgcuuuc ccucagcaut t                                           21

<210> 87
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> control siRNA antisense strand

<400> 87
augcugaggg aaagcgggc                                              19
