                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  NOVEL INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF

<130>  150026WO01

<140>  To be assigned
<141>  2016-07-20

<150>  EP 15182281.4
<151>  2015-08-25

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A8H] of human insulin of Ex. No. 1.

<400>  1

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A8H, A21A] of human insulin of Ex. Nos. 2, 
       11.

<400>  2

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Ala 
            20      


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A8H, A21G] of human insulin of Ex. No. 3.

<400>  3

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A8R] of human insulin of Ex. No. 10.

<400>  4

Gly Ile Val Glu Gln Cys Cys Arg Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A14E] of human insulin of Ex. Nos. 13, 20.

<400>  5

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A14E, A21A] of human insulin of Ex. Nos. 12,
       19.

<400>  6

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Ala 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A21A] of human insulin of Ex. Nos. 5, 8-9, 
       15-17, 23-24.

<400>  7

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Ala 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-chain of analogue [A21G] of human insulin of Ex. Nos. 6, 18.

<400>  8

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain of analogue [B3E, desB27, desB30] of human insulin of Ex.
       Nos. 1-8, 10-11, 15-16, 18, 21-22.


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  ACETYLATION

<400>  9

Phe Val Glu Gln His Leu Cys Gly Asp His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Pro Lys 
            20                  25              


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain of analogue [B3Q, desB27, desB30] of human insulin of Ex.
       Nos. 9, 12-14, 17, 19-20, 23-24.


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  ACETYLATION

<400>  10

Phe Val Gln Gln His Leu Cys Gly Asp His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Pro Lys 
            20                  25              


