                         SEQUENCE LISTING

<110>  Cellectis
 
<120>  CHIMERIC ANTIGEN RECEPTORS WITH INTEGRATED CONTROLLABLE FUNCTIONS

<130>  P81502686PCT00

<150>  PA201570545
<151>  2015-08-24

<150>  EP15202592
<151>  2015-12-23

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  2
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            20                  25                  30          


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        35                  40                  45              


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    50                  55                  60                  


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
65                  70                  75                  80  


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
                85                  90                  


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 (F36V)

<400>  3

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  4
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB T2098L

<400>  4

Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            20                  25                  30          


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        35                  40                  45              


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    50                  55                  60                  


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
65                  70                  75                  80  


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
                85                  90                  


<210>  5
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
1               5                   10                  15      


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
            20                  25                  30          


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
        35                  40                  45              


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
    50                  55                  60                  


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
65                  70                  75                  80  


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
                85                  90                  95      


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
            100                 105                 110         


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
        115                 120                 125             


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
    130                 135                 140                 


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
145                 150                 155                 160 


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
                165                 170                 175     


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
            180                 185                 190         


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
        195                 200                 205             


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
    210                 215                 220                 


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
                245                 250                 255     


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
            260                 265                 270         


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
        275                 280                 285             


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
    290                 295                 300                 


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
305                 310                 315                 320 


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
                325                 330                 335     


Leu Asn Ile Cys Ser Asp Asp Glu 
            340                 


<210>  6
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  7
<211>  804
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Ser Asn Ser Tyr Asp Ser Ser Ser Ile Lys Val Leu Lys Gly Leu 
1               5                   10                  15      


Asp Ala Val Arg Lys Arg Pro Gly Met Tyr Ile Gly Asp Thr Asp Asp 
            20                  25                  30          


Gly Thr Gly Leu His His Met Val Phe Glu Val Val Asp Asn Ala Ile 
        35                  40                  45              


Asp Glu Ala Leu Ala Gly His Cys Lys Glu Ile Ile Val Thr Ile His 
    50                  55                  60                  


Ala Asp Asn Ser Val Ser Val Gln Asp Asp Gly Arg Gly Ile Pro Thr 
65                  70                  75                  80  


Gly Ile His Pro Glu Glu Gly Val Ser Ala Ala Glu Val Ile Met Thr 
                85                  90                  95      


Val Leu His Ala Gly Gly Lys Phe Asp Asp Asn Ser Tyr Lys Val Ser 
            100                 105                 110         


Gly Gly Leu His Gly Val Gly Val Ser Val Val Asn Ala Leu Ser Gln 
        115                 120                 125             


Lys Leu Glu Leu Val Ile Gln Arg Glu Gly Lys Ile His Arg Gln Ile 
    130                 135                 140                 


Tyr Glu His Gly Val Pro Gln Ala Pro Leu Ala Val Thr Gly Glu Thr 
145                 150                 155                 160 


Glu Lys Thr Gly Thr Met Val Arg Phe Trp Pro Ser Leu Glu Thr Phe 
                165                 170                 175     


Thr Asn Val Thr Glu Phe Glu Tyr Glu Ile Leu Ala Lys Arg Leu Arg 
            180                 185                 190         


Glu Leu Ser Phe Leu Asn Ser Gly Val Ser Ile Arg Leu Arg Asp Lys 
        195                 200                 205             


Arg Asp Gly Lys Glu Asp His Phe His Tyr Glu Gly Gly Ile Lys Ala 
    210                 215                 220                 


Phe Val Glu Tyr Leu Asn Lys Asn Lys Thr Pro Ile His Pro Asn Ile 
225                 230                 235                 240 


Phe Tyr Phe Ser Thr Glu Lys Asp Gly Ile Gly Val Glu Val Ala Leu 
                245                 250                 255     


Gln Trp Asn Asp Gly Phe Gln Glu Asn Ile Tyr Cys Phe Thr Asn Asn 
            260                 265                 270         


Ile Pro Gln Arg Asp Gly Gly Thr His Leu Ala Gly Phe Arg Ala Ala 
        275                 280                 285             


Met Thr Arg Thr Leu Asn Ala Tyr Met Asp Lys Glu Gly Tyr Ser Lys 
    290                 295                 300                 


Lys Ala Lys Val Ser Ala Thr Gly Asp Asp Ala Arg Glu Gly Leu Ile 
305                 310                 315                 320 


Ala Val Val Ser Val Lys Val Pro Asp Pro Lys Phe Ser Ser Gln Thr 
                325                 330                 335     


Lys Asp Lys Leu Val Ser Ser Glu Val Lys Ser Ala Val Glu Gln Gln 
            340                 345                 350         


Met Asn Glu Leu Leu Ala Glu Tyr Leu Leu Glu Asn Pro Thr Asp Ala 
        355                 360                 365             


Lys Ile Val Val Gly Lys Ile Ile Asp Ala Ala Arg Ala Arg Glu Ala 
    370                 375                 380                 


Ala Arg Arg Ala Arg Glu Met Thr Arg Arg Lys Gly Ala Leu Asp Leu 
385                 390                 395                 400 


Ala Gly Leu Pro Gly Lys Leu Ala Asp Cys Gln Glu Arg Asp Pro Ala 
                405                 410                 415     


Leu Ser Glu Leu Tyr Leu Val Glu Gly Asp Ser Ala Gly Gly Ser Ala 
            420                 425                 430         


Lys Gln Gly Arg Asn Arg Lys Asn Gln Ala Ile Leu Pro Leu Lys Gly 
        435                 440                 445             


Lys Ile Leu Asn Val Glu Lys Ala Arg Phe Asp Lys Met Leu Ser Ser 
    450                 455                 460                 


Gln Glu Val Ala Thr Leu Ile Thr Ala Leu Gly Cys Gly Ile Gly Arg 
465                 470                 475                 480 


Asp Glu Tyr Asn Pro Asp Lys Leu Arg Tyr His Ser Ile Ile Ile Met 
                485                 490                 495     


Thr Asp Ala Asp Val Asp Gly Ser His Ile Arg Thr Leu Leu Leu Thr 
            500                 505                 510         


Phe Phe Tyr Arg Gln Met Pro Glu Ile Val Glu Arg Gly His Val Tyr 
        515                 520                 525             


Ile Ala Gln Pro Pro Leu Tyr Lys Val Lys Lys Gly Lys Gln Glu Gln 
    530                 535                 540                 


Tyr Ile Lys Asp Asp Glu Ala Met Asp Gln Tyr Gln Ile Ser Ile Ala 
545                 550                 555                 560 


Leu Asp Gly Ala Thr Leu His Thr Asn Ala Ser Ala Pro Ala Leu Ala 
                565                 570                 575     


Gly Glu Ala Leu Glu Lys Leu Val Ser Glu Tyr Asn Ala Thr Gln Lys 
            580                 585                 590         


Met Ile Asn Arg Met Glu Arg Arg Tyr Pro Lys Ala Met Leu Lys Glu 
        595                 600                 605             


Leu Ile Tyr Gln Pro Thr Leu Thr Glu Ala Asp Leu Ser Asp Glu Gln 
    610                 615                 620                 


Thr Val Thr Arg Trp Val Asn Ala Leu Val Ser Glu Leu Asn Asp Lys 
625                 630                 635                 640 


Glu Gln His Gly Ser Gln Trp Lys Phe Asp Val His Thr Asn Ala Glu 
                645                 650                 655     


Gln Asn Leu Phe Glu Pro Ile Val Arg Val Arg Thr His Gly Val Asp 
            660                 665                 670         


Thr Asp Tyr Pro Leu Asp His Glu Phe Ile Thr Gly Gly Glu Tyr Arg 
        675                 680                 685             


Arg Ile Cys Thr Leu Gly Glu Lys Leu Arg Gly Leu Leu Glu Glu Asp 
    690                 695                 700                 


Ala Phe Ile Glu Arg Gly Glu Arg Arg Gln Pro Val Ala Ser Phe Glu 
705                 710                 715                 720 


Gln Ala Leu Asp Trp Leu Val Lys Glu Ser Arg Arg Gly Leu Ser Ile 
                725                 730                 735     


Gln Arg Tyr Lys Gly Leu Gly Glu Met Asn Pro Glu Gln Leu Trp Glu 
            740                 745                 750         


Thr Thr Met Asp Pro Glu Ser Arg Arg Met Leu Arg Val Thr Val Lys 
        755                 760                 765             


Asp Ala Ile Ala Ala Asp Gln Leu Phe Thr Thr Leu Met Gly Asp Ala 
    770                 775                 780                 


Val Glu Pro Arg Arg Ala Phe Ile Glu Glu Asn Ala Leu Lys Ala Ala 
785                 790                 795                 800 


Asn Ile Asp Ile 
                


<210>  8
<211>  92
<212>  PRT
<213>  Arabidopsis thaliana

<400>  8

Met Lys Arg Asp His His His His His His Gln Asp Lys Lys Thr Met 
1               5                   10                  15      


Met Met Asn Glu Glu Asp Asp Gly Asn Gly Met Asp Glu Leu Leu Ala 
            20                  25                  30          


Val Leu Gly Tyr Lys Val Arg Ser Ser Glu Met Ala Asp Val Ala Gln 
        35                  40                  45              


Lys Leu Glu Gln Leu Glu Val Met Met Ser Asn Val Gln Glu Asp Asp 
    50                  55                  60                  


Leu Ser Gln Leu Ala Thr Glu Thr Val His Tyr Asn Pro Ala Glu Leu 
65                  70                  75                  80  


Tyr Thr Trp Leu Asp Ser Met Leu Thr Asp Leu Asn 
                85                  90          


<210>  9
<211>  345
<212>  PRT
<213>  Arabidopsis thaliana

<400>  9

Met Ala Ala Ser Asp Glu Val Asn Leu Ile Glu Ser Arg Thr Val Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Val Ala Tyr Asn 
            20                  25                  30          


Ile Leu Arg Arg Pro Asp Gly Thr Phe Asn Arg His Leu Ala Glu Tyr 
        35                  40                  45              


Leu Asp Arg Lys Val Thr Ala Asn Ala Asn Pro Val Asp Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp Val Leu Ile Asp Arg Arg Ile Asn Leu Leu Ser Arg Val 
65                  70                  75                  80  


Tyr Arg Pro Ala Tyr Ala Asp Gln Glu Gln Pro Pro Ser Ile Leu Asp 
                85                  90                  95      


Leu Glu Lys Pro Val Asp Gly Asp Ile Val Pro Val Ile Leu Phe Phe 
            100                 105                 110         


His Gly Gly Ser Phe Ala His Ser Ser Ala Asn Ser Ala Ile Tyr Asp 
        115                 120                 125             


Thr Leu Cys Arg Arg Leu Val Gly Leu Cys Lys Cys Val Val Val Ser 
    130                 135                 140                 


Val Asn Tyr Arg Arg Ala Pro Glu Asn Pro Tyr Pro Cys Ala Tyr Asp 
145                 150                 155                 160 


Asp Gly Trp Ile Ala Leu Asn Trp Val Asn Ser Arg Ser Trp Leu Lys 
                165                 170                 175     


Ser Lys Lys Asp Ser Lys Val His Ile Phe Leu Ala Gly Asp Ser Ser 
            180                 185                 190         


Gly Gly Asn Ile Ala His Asn Val Ala Leu Arg Ala Gly Glu Ser Gly 
        195                 200                 205             


Ile Asp Val Leu Gly Asn Ile Leu Leu Asn Pro Met Phe Gly Gly Asn 
    210                 215                 220                 


Glu Arg Thr Glu Ser Glu Lys Ser Leu Asp Gly Lys Tyr Phe Val Thr 
225                 230                 235                 240 


Val Arg Asp Arg Asp Trp Tyr Trp Lys Ala Phe Leu Pro Glu Gly Glu 
                245                 250                 255     


Asp Arg Glu His Pro Ala Cys Asn Pro Phe Ser Pro Arg Gly Lys Ser 
            260                 265                 270         


Leu Glu Gly Val Ser Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu 
        275                 280                 285             


Asp Leu Ile Arg Asp Trp Gln Leu Ala Tyr Ala Glu Gly Leu Lys Lys 
    290                 295                 300                 


Ala Gly Gln Glu Val Lys Leu Met His Leu Glu Lys Ala Thr Val Gly 
305                 310                 315                 320 


Phe Tyr Leu Leu Pro Asn Asn Asn His Phe His Asn Val Met Asp Glu 
                325                 330                 335     


Ile Ser Ala Phe Val Asn Ala Glu Cys 
            340                 345 


<210>  10
<211>  358
<212>  PRT
<213>  Arabidopsis thaliana

<400>  10

Met Ala Gly Gly Asn Glu Val Asn Leu Asn Glu Cys Lys Arg Ile Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Leu Ala Tyr Lys 
            20                  25                  30          


Val Leu Arg Arg Pro Asp Gly Ser Phe Asn Arg Asp Leu Ala Glu Phe 
        35                  40                  45              


Leu Asp Arg Lys Val Pro Ala Asn Ser Phe Pro Leu Asp Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp His Val Asp Ser Thr Thr Asn Leu Leu Thr Arg Ile Tyr 
65                  70                  75                  80  


Gln Pro Ala Ser Leu Leu His Gln Thr Arg His Gly Thr Leu Glu Leu 
                85                  90                  95      


Thr Lys Pro Leu Ser Thr Thr Glu Ile Val Pro Val Leu Ile Phe Phe 
            100                 105                 110         


His Gly Gly Ser Phe Thr His Ser Ser Ala Asn Ser Ala Ile Tyr Asp 
        115                 120                 125             


Thr Phe Cys Arg Arg Leu Val Thr Ile Cys Gly Val Val Val Val Ser 
    130                 135                 140                 


Val Asp Tyr Arg Arg Ser Pro Glu His Arg Tyr Pro Cys Ala Tyr Asp 
145                 150                 155                 160 


Asp Gly Trp Asn Ala Leu Asn Trp Val Lys Ser Arg Val Trp Leu Gln 
                165                 170                 175     


Ser Gly Lys Asp Ser Asn Val Tyr Val Tyr Leu Ala Gly Asp Ser Ser 
            180                 185                 190         


Gly Gly Asn Ile Ala His Asn Val Ala Val Arg Ala Thr Asn Glu Gly 
        195                 200                 205             


Val Lys Val Leu Gly Asn Ile Leu Leu His Pro Met Phe Gly Gly Gln 
    210                 215                 220                 


Glu Arg Thr Gln Ser Glu Lys Thr Leu Asp Gly Lys Tyr Phe Val Thr 
225                 230                 235                 240 


Ile Gln Asp Arg Asp Trp Tyr Trp Arg Ala Tyr Leu Pro Glu Gly Glu 
                245                 250                 255     


Asp Arg Asp His Pro Ala Cys Asn Pro Phe Gly Pro Arg Gly Gln Ser 
            260                 265                 270         


Leu Lys Gly Val Asn Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu 
        275                 280                 285             


Asp Leu Val Gln Asp Trp Gln Leu Ala Tyr Val Asp Gly Leu Lys Lys 
    290                 295                 300                 


Thr Gly Leu Glu Val Asn Leu Leu Tyr Leu Lys Gln Ala Thr Ile Gly 
305                 310                 315                 320 


Phe Tyr Phe Leu Pro Asn Asn Asp His Phe His Cys Leu Met Glu Glu 
                325                 330                 335     


Leu Asn Lys Phe Val His Ser Ile Glu Asp Ser Gln Ser Lys Ser Ser 
            340                 345                 350         


Pro Val Leu Leu Thr Pro 
        355             


<210>  11
<211>  344
<212>  PRT
<213>  Arabidopsis thaliana

<400>  11

Met Ala Gly Ser Glu Glu Val Asn Leu Ile Glu Ser Lys Thr Val Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Leu Ala Tyr Asn 
            20                  25                  30          


Leu Leu Arg Arg Pro Asp Gly Thr Phe Asn Arg His Leu Ala Glu Phe 
        35                  40                  45              


Leu Asp Arg Lys Val Pro Ala Asn Ala Asn Pro Val Asn Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp Val Ile Ile Asp Arg Gln Thr Asn Leu Leu Ser Arg Val 
65                  70                  75                  80  


Tyr Arg Pro Ala Asp Ala Gly Thr Ser Pro Ser Ile Thr Asp Leu Gln 
                85                  90                  95      


Asn Pro Val Asp Gly Glu Ile Val Pro Val Ile Val Phe Phe His Gly 
            100                 105                 110         


Gly Ser Phe Ala His Ser Ser Ala Asn Ser Ala Ile Tyr Asp Thr Leu 
        115                 120                 125             


Cys Arg Arg Leu Val Gly Leu Cys Gly Ala Val Val Val Ser Val Asn 
    130                 135                 140                 


Tyr Arg Arg Ala Pro Glu Asn Arg Tyr Pro Cys Ala Tyr Asp Asp Gly 
145                 150                 155                 160 


Trp Ala Val Leu Lys Trp Val Asn Ser Ser Ser Trp Leu Arg Ser Lys 
                165                 170                 175     


Lys Asp Ser Lys Val Arg Ile Phe Leu Ala Gly Asp Ser Ser Gly Gly 
            180                 185                 190         


Asn Ile Val His Asn Val Ala Val Arg Ala Val Glu Ser Arg Ile Asp 
        195                 200                 205             


Val Leu Gly Asn Ile Leu Leu Asn Pro Met Phe Gly Gly Thr Glu Arg 
    210                 215                 220                 


Thr Glu Ser Glu Lys Arg Leu Asp Gly Lys Tyr Phe Val Thr Val Arg 
225                 230                 235                 240 


Asp Arg Asp Trp Tyr Trp Arg Ala Phe Leu Pro Glu Gly Glu Asp Arg 
                245                 250                 255     


Glu His Pro Ala Cys Ser Pro Phe Gly Pro Arg Ser Lys Ser Leu Glu 
            260                 265                 270         


Gly Leu Ser Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu Asp Leu 
        275                 280                 285             


Ile Gln Asp Trp Gln Leu Lys Tyr Ala Glu Gly Leu Lys Lys Ala Gly 
    290                 295                 300                 


Gln Glu Val Lys Leu Leu Tyr Leu Glu Gln Ala Thr Ile Gly Phe Tyr 
305                 310                 315                 320 


Leu Leu Pro Asn Asn Asn His Phe His Thr Val Met Asp Glu Ile Ala 
                325                 330                 335     


Ala Phe Val Asn Ala Glu Cys Gln 
            340                 


<210>  12
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Snap-tag

<400>  12

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Arg Ile Ile 
            20                  25                  30          


Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly Gly Tyr Glu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


<210>  13
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Halo-tag

<400>  13

Met Ala Glu Ile Gly Thr Gly Phe Pro Phe Asp Pro His Tyr Val Glu 
1               5                   10                  15      


Val Leu Gly Glu Arg Met His Tyr Val Asp Val Gly Pro Arg Asp Gly 
            20                  25                  30          


Thr Pro Val Leu Phe Leu His Gly Asn Pro Thr Ser Ser Tyr Val Trp 
        35                  40                  45              


Arg Asn Ile Ile Pro His Val Ala Pro Thr His Arg Cys Ile Ala Pro 
    50                  55                  60                  


Asp Leu Ile Gly Met Gly Lys Ser Asp Lys Pro Asp Leu Gly Tyr Phe 
65                  70                  75                  80  


Phe Asp Asp His Val Arg Phe Met Asp Ala Phe Ile Glu Ala Leu Gly 
                85                  90                  95      


Leu Glu Glu Val Val Leu Val Ile His Asp Trp Gly Ser Ala Leu Gly 
            100                 105                 110         


Phe His Trp Ala Lys Arg Asn Pro Glu Arg Val Lys Gly Ile Ala Phe 
        115                 120                 125             


Met Glu Phe Ile Arg Pro Ile Pro Thr Trp Asp Glu Trp Pro Glu Phe 
    130                 135                 140                 


Ala Arg Glu Thr Phe Gln Ala Phe Arg Thr Thr Asp Val Gly Arg Lys 
145                 150                 155                 160 


Leu Ile Ile Asp Gln Asn Val Phe Ile Glu Gly Thr Leu Pro Met Gly 
                165                 170                 175     


Val Val Arg Pro Leu Thr Glu Val Glu Met Asp His Tyr Arg Glu Pro 
            180                 185                 190         


Phe Leu Asn Pro Val Asp Arg Glu Pro Leu Trp Arg Phe Pro Asn Glu 
        195                 200                 205             


Leu Pro Ile Ala Gly Glu Pro Ala Asn Ile Val Ala Leu Val Glu Glu 
    210                 215                 220                 


Tyr Met Asp Trp Leu His Gln Ser Pro Val Pro Lys Leu Leu Phe Trp 
225                 230                 235                 240 


Gly Thr Pro Gly Val Leu Ile Pro Pro Ala Glu Ala Ala Arg Leu Ala 
                245                 250                 255     


Lys Ser Leu Pro Asn Cys Lys Ala Val Asp Ile Gly Pro Gly Leu Asn 
            260                 265                 270         


Leu Leu Gln Glu Asp Asn Pro Asp Leu Ile Gly Ser Glu Ile Ala Arg 
        275                 280                 285             


Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295         


<210>  14
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIP-tag

<400>  14

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Arg Ile Ile 
            20                  25                  30          


Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Ile Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Glu Ser His Leu Ala Ala Leu Val Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Asn Thr Ala Leu Asp Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Gln Gly Asp Ser Asp Val Gly Pro Tyr Leu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


<210>  15
<211>  159
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Arg Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155                 


<210>  16
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser Glu Asn Pro 
1               5                   10                  15      


Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu Thr Pro Thr 
            20                  25                  30          


Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala Gly 
        35                  40                  45              


Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr Leu 
    50                  55                  60                  


Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala Lys 
65                  70                  75                  80  


Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr Leu 
                85                  90                  95      


Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp Arg 
            100                 105                 110         


Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp Leu 
        115                 120                 125             


Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln Cys 
    130                 135                 140                 


Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val Ser 
145                 150                 155                 160 


Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser Val 
                165                 170                 175     


Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg Met 
            180                 185                 190         


Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly Asn 
        195                 200                 205             


Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    210                 215                 220                 


Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln Thr 
225                 230                 235                 240 


Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala Glu 
                245                 250                 255     


Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys Lys 
            260                 265                 270         


Leu Leu Phe His Gln Lys 
        275             


<210>  17
<211>  176
<212>  PRT
<213>  Arabidopsis thaliana

<400>  17

Gln Asp Glu Phe Thr Gln Leu Ser Gln Ser Ile Ala Glu Phe His Thr 
1               5                   10                  15      


Tyr Gln Leu Gly Asn Gly Arg Cys Ser Ser Leu Leu Ala Gln Arg Ile 
            20                  25                  30          


His Ala Pro Pro Glu Thr Val Trp Ser Val Val Arg Arg Phe Asp Arg 
        35                  40                  45              


Pro Gln Ile Tyr Lys His Phe Ile Lys Ser Cys Asn Val Ser Glu Asp 
    50                  55                  60                  


Phe Glu Met Arg Val Gly Cys Thr Arg Asp Val Asn Val Ile Ser Gly 
65                  70                  75                  80  


Leu Pro Ala Asn Thr Ser Arg Glu Arg Leu Asp Leu Leu Asp Asp Asp 
                85                  90                  95      


Arg Arg Val Thr Gly Phe Ser Ile Thr Gly Gly Glu His Arg Leu Arg 
            100                 105                 110         


Asn Tyr Lys Ser Val Thr Thr Val His Arg Phe Glu Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Arg Ile Trp Thr Val Val Leu Glu Ser Tyr Val Val Asp Val 
    130                 135                 140                 


Pro Glu Gly Asn Ser Glu Glu Asp Thr Arg Leu Phe Ala Asp Thr Val 
145                 150                 155                 160 


Ile Arg Leu Asn Leu Gln Lys Leu Ala Ser Ile Thr Glu Ala Met Asn 
                165                 170                 175     


<210>  18
<211>  298
<212>  PRT
<213>  Arabidopsis thaliana

<400>  18

Val Pro Leu Tyr Gly Phe Thr Ser Ile Cys Gly Arg Arg Pro Glu Met 
1               5                   10                  15      


Glu Asp Ala Val Ser Thr Ile Pro Arg Phe Leu Gln Ser Ser Ser Gly 
            20                  25                  30          


Ser Met Leu Asp Gly Arg Phe Asp Pro Gln Ser Ala Ala His Phe Phe 
        35                  40                  45              


Gly Val Tyr Asp Gly His Gly Gly Ser Gln Val Ala Asn Tyr Cys Arg 
    50                  55                  60                  


Glu Arg Met His Leu Ala Leu Ala Glu Glu Ile Ala Lys Glu Lys Pro 
65                  70                  75                  80  


Met Leu Cys Asp Gly Asp Thr Trp Leu Glu Lys Trp Lys Lys Ala Leu 
                85                  90                  95      


Phe Asn Ser Phe Leu Arg Val Asp Ser Glu Ile Glu Ser Val Ala Pro 
            100                 105                 110         


Glu Thr Val Gly Ser Thr Ser Val Val Ala Val Val Phe Pro Ser His 
        115                 120                 125             


Ile Phe Val Ala Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Gly 
    130                 135                 140                 


Lys Thr Ala Leu Pro Leu Ser Val Asp His Lys Pro Asp Arg Glu Asp 
145                 150                 155                 160 


Glu Ala Ala Arg Ile Glu Ala Ala Gly Gly Lys Val Ile Gln Trp Asn 
                165                 170                 175     


Gly Ala Arg Val Phe Gly Val Leu Ala Met Ser Arg Ser Ile Gly Asp 
            180                 185                 190         


Arg Tyr Leu Lys Pro Ser Ile Ile Pro Asp Pro Glu Val Thr Ala Val 
        195                 200                 205             


Lys Arg Val Lys Glu Asp Asp Cys Leu Ile Leu Ala Ser Asp Gly Val 
    210                 215                 220                 


Trp Asp Val Met Thr Asp Glu Glu Ala Cys Glu Met Ala Arg Lys Arg 
225                 230                 235                 240 


Ile Leu Leu Trp His Lys Lys Asn Ala Val Ala Gly Asp Ala Ser Leu 
                245                 250                 255     


Leu Ala Asp Glu Arg Arg Lys Glu Gly Lys Asp Pro Ala Ala Met Ser 
            260                 265                 270         


Ala Ala Glu Tyr Leu Ser Lys Leu Ala Ile Gln Arg Gly Ser Lys Asp 
        275                 280                 285             


Asn Ile Ser Val Val Val Val Asp Leu Lys 
    290                 295             


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-EAAAR-linker

<400>  19

Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu 
1               5                   10                  15      


Ala Ala Ala Arg 
            20  


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS-4x-EAAAR-linker

<400>  20

Gly Ser Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala 
1               5                   10                  15      


Arg Glu Ala Ala Ala Arg 
            20          


<210>  21
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  22
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  23
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  25

<211>  121
<212>  PRT
<213>  mus musculus

<220>
<223>  fragment of anti-human CD19 monoclonal antibody 4G7 immunoglobulin gamma1 heavy chain-(residues 20-140)

<400>  25
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  26

<211>  115
<212>  PRT
<213>  mus musculus

<220>
<223>  fragment of anti-human CD19 monoclonal antibody 4G7 immunoglobulin kappa light chain (residues 21-130)

<400>  26
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp 
        115 


<210>  27

<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  fragment of anti-human CD19 monoclonal antibody 4G7 immunoglobulin kappa light chain

<400>  27
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ser Asp Pro 
        115     


<210>  28
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  29
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu 
    210                 215 


<210>  30
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
        35                  40              


<210>  31
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  32

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  33
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  33

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  34
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
            20                  25                  30          


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
        35                  40                  45              


Pro Lys Asn Asn 
    50          


<210>  35
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
        35                  40              


<210>  36
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu 
    210                 215 


<210>  37
<211>  2549
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  38
<211>  2541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS24707

<400>  38
atgatcccag ccgtggtcct gctgctgctg ctgctggtgg agcaggcagc tgcactggga       60

gaaccccagc tgtgctacat cctggacgcc attctgttcc tgtacggcat tgtgctgaca      120

ctgctgtatt gtaggctgaa gatccaggtc cgcaaagccg ctattacttc atatgagaag      180

agccgcgtga agttcagccg atccgctgac gcaccagcat accagcaggg acagaaccag      240

ctgtataacg agctgaatct gggacggaga gaggaatacg acgtcctgga taagaggcgc      300

ggcagggatc ctgaaatggg cgggaagcct cgacggaaaa acccacagga ggggctgtac      360

aatgaactgc agaaggacaa aatggctgag gcatatagtg aaatcggaat gaagggcgag      420

agaaggcgcg ggaaaggaca cgatggcctg taccaggggc tgtccaccgc cacaaaagac      480

acttatgatg cactgcatat gcaggccctg ccccctcgcg gcagcggggc caccaacttc      540

tccctgctga agcaggctgg agacgtggag gaaaatcccg gccctatggc tcccgcaatg      600

gagtccccta cactgctgtg cgtggcactg ctgttctttg caccagatgg cgtgctggca      660

gaggtccagc tgcagcagtc aggaccagaa ctgatcaaac ccggagcatc tgtgaaaatg      720

agttgtaagg cctcaggcta tactttcacc tcttacgtga tgcactgggt caagcagaaa      780

cctggacagg gcctggagtg gatcggctat attaatccat acaacgacgg gaccaagtac      840

aacgaaaagt ttaaaggcaa ggcaacactg actagtgata agagctcctc tactgcttac      900

atggagctga gttcactgac cagcgaagac tccgctgtgt actattgcgc aagaggaacc      960

tactattacg gctctagggt gttcgattac tgggggcagg gaaccacact gacagtcagc     1020

tccggaggag gaggatccgg aggaggaggg tctggaggcg ggggaagtga catcgtgatg     1080

acacaggccg ctcctagcat tccagtgact cccggcgagt cagtcagcat ctcctgtcgg     1140

tctagtaaga gcctgctgaa ctccaatgga aacacatatc tgtactggtt tctgcagagg     1200

cctggccagt ccccacagct gctgatctat cgcatgtcta acctggccag tggcgtgccc     1260

gatcggttct ctggcagtgg gtcaggaacc gcctttacac tgaggattag ccgcgtcgag     1320

gctgaagacg tgggggtcta ttactgcatg cagcatctgg agtacccttt cacatttggc     1380

gccgggacta aactggaact gaagcgcgcc gatactacca caccagctcc acgaccacct     1440

actcctgcac caaccattgc ttcacagcct ctgagcctgc gaccagaagc ttgccggcca     1500

gcagcaggag gagcagtgca caccagaggc ctggacttcg cctgtgattt ctttatcccc     1560

ctgctggtgg tcattctgtt cgccgtggac actgggctgt ttatctccac ccagcagcag     1620

gtcacattcc tgctgaaaat taagcggacc agaaagggct tccggctgct gaatccccat     1680

cctaaaccaa accccaagaa caatggaagc ggagagggac gaggatccct gctgacctgc     1740

ggggacgtgg aggaaaaccc aggacctatg gacactgagt ctaaccggag agccaatctg     1800

gctctgccac aggaacccag ctccgtgccc gcattcgagg tcctggaaat ctctcctcag     1860

gaggtgtcta gtgggcgcct gctgaagagt gcctcaagcc cccctctgca cacttggctg     1920

accgtgctga agaaagagca ggaattcctg ggagtcaccc agatcctgac agctatgatt     1980

tgcctgtgtt ttggcacagt ggtctgcagt gtgctggaca tctcacatat tgagggggat     2040

atcttctcct cttttaaggc tgggtaccct ttttggggag caatcttctt tagcatttcc     2100

ggaatgctgt caatcattag cgaaaggcgc aacgcaacat atctggtgcg aggaagcctg     2160

ggcgcaaata ctgccagttc aatcgccggc gggacaggca tcactattct gatcattaac     2220

ctgaagaaaa gcctggctta catccacatt cattcctgcc agaagttctt tgagactaaa     2280

tgtttcatgg cctcttttag taccgaaatc gtggtcatga tgctgttcct gaccattctg     2340

gggctgggat ccgccgtgtc tctgacaatc tgcggcgctg gggaggaact gaagggcaac     2400

aaggtcccag agaagcgagg gcggaagaaa ctgctgtata ttttcaaaca gccttttatg     2460

agaccagtgc agaccacaca ggaggaagat ggctgctcct gtaggtttcc cgaggaagag     2520

gaaggaggct gtgagctgtg a                                               2541


<210>  39
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain of mutlti-chain chimeric antigen receptor

<400>  39

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ala Asp Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
                325                 330                 335     


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
            340                 345                 350         


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
        355                 360                 365             


Asn Pro Lys Asn Asn 
    370             


<210>  40
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain of multi-chain chimeric antigen receptor

<400>  40

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu 
    


<210>  41
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gamma chain of multi-chain chimeric antigen receptor

<400>  41

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val Lys 
    50                  55                  60                  


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
65                  70                  75                  80  


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                85                  90                  95      


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            100                 105                 110         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        115                 120                 125             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    130                 135                 140                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
145                 150                 155                 160 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170             


<210>  42
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFV-GG

<400>  42
gaagacacat ggctcccgca atggagtccc ctacactgct gtgcgtggca ctgctgttct       60

ttgcaccaga tggcgtgctg gcagaggtcc agctgcagca gtcaggacca gaactgatca      120

aacccggagc atctgtgaaa atgagttgta aggcctcagg ctatactttc acctcttacg      180

tgatgcactg ggtcaagcag aaacctggac agggcctgga gtggatcggc tatattaatc      240

catacaacga cgggaccaag tacaacgaaa agtttaaagg caaggcaaca ctgactagtg      300

ataagagctc ctctactgct tacatggagc tgagttcact gaccagcgag gactccgctg      360

tgtactattg cgcaagagga acctactatt acggctctag ggtgttcgat tactgggggc      420

agggaaccac actgacagtc agctccggag gaggagggtc cggaggagga gggtctggag      480

gcgggggaag tgacatcgtg atgacacagg ccgctcctag cattccagtg actcccggcg      540

agtcagtcag catctcctgt cggtctagta agagcctgct gaactccaat ggaaacacat      600

atctgtactg gtttctgcag aggcctggcc agtccccaca gctgctgatc tatcgcatgt      660

ctaacctggc cagtggcgtg cccgatcggt tctctggcag tgggtcagga accgccttta      720

cactgaggat tagccgcgtc gaggctgagg acgtgggggt ctattactgc atgcagcatc      780

tggagtaccc tttcacattt ggcgccggga ctaaactgga actgaagcgc tcggatcccg      840

gaagacgtct tc                                                          852


<210>  43
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge-trans-intra-GG

<400>  43
gaagacactc ccactaccac accagctcca cgaccaccta ctcctgcacc aaccattgct       60

tcacagcctc tgagcctgcg accagaagcc tgccggccag cagcaggagg agcagtgcac      120

accagaggcc tggacttcgc ctgtgatttc tttatccccc tgctggtggt cattctgttc      180

gccgtggaca ctgggctgtt tatctccacc cagcagcagg tcacattcct gctgaaaatt      240

aagcggacca gaaagggctt ccggctgctg aatccccatc ctaaaccaaa ccccaagaac      300

aatgaatacg tcttc                                                       315


<210>  44
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FRB-GG

<400>  44
gaagacacga agcggaggca gggttgctat cctttggcat gaaatgtggc atgaggggct       60

cgaggaggcc agtcggctgt acttcggaga aagaaatgtg aagggtatgt tcgaggtctt      120

ggaacccctg cacgccatga tggagcgagg gcctcaaacc ctcaaggaga catcttttaa      180

ccaggcatat ggtagggatc tcatggaagc ccaggaatgg tgcagaaaat acatgaaatc      240

cggcaacgtg aaggacctga ctcaggcttg ggacctgtat taccacgtat ttcggcgcat      300

tggcagcggg gctcccacgt cttc                                             324


<210>  45
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FKBP-GG

<400>  45
gaagacacga agcggaggcg tgcaagtcga gactatttca ccaggcgacg gtagaacttt       60

tccaaaacgg ggtcagacct gcgtcgttca ttacacaggc atgctcgagg atggcaagaa      120

gtttgactct agtagggatc gtaacaaacc cttcaagttc atgctgggta agcaggaggt      180

gatccgcggc tgggaggaag gggtggcaca gatgtctgtg ggacagcgag ccaagctgac      240

catcagccct gattatgctt acggagccac cgggcacccc ggtatcatac ctccccacgc      300

tacactggtt ttcgacgtag aactccttaa attggaaggc agcggggctc ccacgtcttc      360


<210>  46
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB-FKBP fragment including a GS-4x-EAAAR-linker

<400>  46

Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            20                  25                  30          


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        35                  40                  45              


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    50                  55                  60                  


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
65                  70                  75                  80  


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly Ser 
                85                  90                  95      


Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu 
            100                 105                 110         


Ala Ala Ala Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
        115                 120                 125             


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
    130                 135                 140                 


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
145                 150                 155                 160 


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
                165                 170                 175     


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
            180                 185                 190         


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
        195                 200                 205             


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    210                 215                 220             


<210>  47
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP-FRB fragment including a four-EAAAR-linker

<400>  47

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu Ala Ala Ala Arg 
            100                 105                 110         


Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly 
        115                 120                 125             


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
    130                 135                 140                 


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
145                 150                 155                 160 


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
                165                 170                 175     


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
            180                 185                 190         


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
        195                 200                 205             


Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
    210                 215                 220         


<210>  48
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26563

<400>  48
atggctcccg caatggagtc ccctacactg ctgtgcgtgg cactgctgtt ctttgcacca       60

gatggcgtgc tggcagaggt ccagctgcag cagtcaggac cagaactgat caaacccgga      120

gcatctgtga aaatgagttg taaggcctca ggctatactt tcacctctta cgtgatgcac      180

tgggtcaagc agaaacctgg acagggcctg gagtggatcg gctatattaa tccatacaac      240

gacgggacca agtacaacga aaagtttaaa ggcaaggcaa cactgactag tgataagagc      300

tcctctactg cttacatgga gctgagttca ctgaccagcg aggactccgc tgtgtactat      360

tgcgcaagag gaacctacta ttacggctct agggtgttcg attactgggg gcagggaacc      420

acactgacag tcagctccgg aggaggaggg tccggaggag gagggtctgg aggcggggga      480

agtgacatcg tgatgacaca ggccgctcct agcattccag tgactcccgg cgagtcagtc      540

agcatctcct gtcggtctag taagagcctg ctgaactcca atggaaacac atatctgtac      600

tggtttctgc agaggcctgg ccagtcccca cagctgctga tctatcgcat gtctaacctg      660

gccagtggcg tgcccgatcg gttctctggc agtgggtcag gaaccgcctt tacactgagg      720

attagccgcg tcgaggctga ggacgtgggg gtctattact gcatgcagca tctggagtac      780

cctttcacat ttggcgccgg gactaaactg gaactgaagc gctcggatcc cggaagcgga      840

ggcgtgcaag tcgagactat ttcaccaggc gacggtagaa cttttccaaa acggggtcag      900

acctgcgtcg ttcattacac aggcatgctc gaggatggca agaagtttga ctctagtagg      960

gatcgtaaca aacccttcaa gttcatgctg ggtaagcagg aggtgatccg cggctgggag     1020

gaaggggtgg cacagatgtc tgtgggacag cgagccaagc tgaccatcag ccctgattat     1080

gcttacggag ccaccgggca ccccggtatc atacctcccc acgctacact ggttttcgac     1140

gtagaactcc ttaaattgga aggcagcggg gctcccacta ccacaccagc tccacgacca     1200

cctactcctg caccaaccat tgcttcacag cctctgagcc tgcgaccaga agcctgccgg     1260

ccagcagcag gaggagcagt gcacaccaga ggcctggact tcgcctgtga tttctttatc     1320

cccctgctgg tggtcattct gttcgccgtg gacactgggc tgtttatctc cacccagcag     1380

caggtcacat tcctgctgaa aattaagcgg accagaaagg gcttccggct gctgaatccc     1440

catcctaaac caaaccccaa gaacaatgaa                                      1470


<210>  49
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26564

<400>  49
atggctcccg caatggagtc ccctacactg ctgtgcgtgg cactgctgtt ctttgcacca       60

gatggcgtgc tggcagaggt ccagctgcag cagtcaggac cagaactgat caaacccgga      120

gcatctgtga aaatgagttg taaggcctca ggctatactt tcacctctta cgtgatgcac      180

tgggtcaagc agaaacctgg acagggcctg gagtggatcg gctatattaa tccatacaac      240

gacgggacca agtacaacga aaagtttaaa ggcaaggcaa cactgactag tgataagagc      300

tcctctactg cttacatgga gctgagttca ctgaccagcg aggactccgc tgtgtactat      360

tgcgcaagag gaacctacta ttacggctct agggtgttcg attactgggg gcagggaacc      420

acactgacag tcagctccgg aggaggaggg tccggaggag gagggtctgg aggcggggga      480

agtgacatcg tgatgacaca ggccgctcct agcattccag tgactcccgg cgagtcagtc      540

agcatctcct gtcggtctag taagagcctg ctgaactcca atggaaacac atatctgtac      600

tggtttctgc agaggcctgg ccagtcccca cagctgctga tctatcgcat gtctaacctg      660

gccagtggcg tgcccgatcg gttctctggc agtgggtcag gaaccgcctt tacactgagg      720

attagccgcg tcgaggctga ggacgtgggg gtctattact gcatgcagca tctggagtac      780

cctttcacat ttggcgccgg gactaaactg gaactgaagc gctcggatcc cggaagcgga      840

ggcagggttg ctatcctttg gcatgaaatg tggcatgagg ggctcgagga ggccagtcgg      900

ctgtacttcg gagaaagaaa tgtgaagggt atgttcgagg tcttggaacc cctgcacgcc      960

atgatggagc gagggcctca aaccctcaag gagacatctt ttaaccaggc atatggtagg     1020

gatctcatgg aagcccagga atggtgcaga aaatacatga aatccggcaa cgtgaaggac     1080

ctgactcagg cttgggacct gtattaccac gtatttcggc gcattggcag cggggctccc     1140

actaccacac cagctccacg accacctact cctgcaccaa ccattgcttc acagcctctg     1200

agcctgcgac cagaagcctg ccggccagca gcaggaggag cagtgcacac cagaggcctg     1260

gacttcgcct gtgatttctt tatccccctg ctggtggtca ttctgttcgc cgtggacact     1320

gggctgttta tctccaccca gcagcaggtc acattcctgc tgaaaattaa gcggaccaga     1380

aagggcttcc ggctgctgaa tccccatcct aaaccaaacc ccaagaacaa tgaa           1434


<210>  50
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26881

<400>  50
atggctcccg caatggagtc ccctacactg ctgtgcgtgg cactgctgtt ctttgcacca       60

gatggcgtgc tggcagaggt ccagctgcag cagtcaggac cagaactgat caaacccgga      120

gcatctgtga aaatgagttg taaggcctca ggctatactt tcacctctta cgtgatgcac      180

tgggtcaagc agaaacctgg acagggcctg gagtggatcg gctatattaa tccatacaac      240

gacgggacca agtacaacga aaagtttaaa ggcaaggcaa cactgactag tgataagagc      300

tcctctactg cttacatgga gctgagttca ctgaccagcg aggactccgc tgtgtactat      360

tgcgcaagag gaacctacta ttacggctct agggtgttcg attactgggg gcagggaacc      420

acactgacag tcagctccgg aggaggaggg tccggaggag gagggtctgg aggcggggga      480

agtgacatcg tgatgacaca ggccgctcct agcattccag tgactcccgg cgagtcagtc      540

agcatctcct gtcggtctag taagagcctg ctgaactcca atggaaacac atatctgtac      600

tggtttctgc agaggcctgg ccagtcccca cagctgctga tctatcgcat gtctaacctg      660

gccagtggcg tgcccgatcg gttctctggc agtgggtcag gaaccgcctt tacactgagg      720

attagccgcg tcgaggctga ggacgtgggg gtctattact gcatgcagca tctggagtac      780

cctttcacat ttggcgccgg gactaaactg gaactgaagc gctcggatcc cggaagcgga      840

ggcgtgcaag tcgagactat ttcaccaggc gacggtagaa cttttccaaa acggggtcag      900

acctgcgtcg ttcattacac aggcatgctc gaggatggca agaagtttga ctctagtagg      960

gatcgtaaca aacccttcaa gttcatgctg ggtaagcagg aggtgatccg cggctgggag     1020

gaaggggtgg cacagatgtc tgtgggacag cgagccaagc tgaccatcag ccctgattat     1080

gcttacggag ccaccgggca ccccggtatc atacctcccc acgctacact ggttttcgac     1140

gtagaactcc ttaaattgga agaagcagcg gctcgcgaag ctgcagcgcg agaggctgct     1200

gcccgggagg cggctgcacg gggcagggtt gctatccttt ggcatgaaat gtggcatgag     1260

gggctcgagg aggccagtcg gctgtacttc ggagaaagaa atgtgaaggg tatgttcgag     1320

gtcttggaac ccctgcacgc catgatggag cgagggcctc aaaccctcaa ggagacatct     1380

tttaaccagg catatggtag ggatctcatg gaagcccagg aatggtgcag aaaatacatg     1440

aaatccggca acgtgaagga cctgactcag gcttgggacc tgtattacca cgtatttcgg     1500

cgcattggca gcggggctcc cactaccaca ccagctccac gaccacctac tcctgcacca     1560

accattgctt cacagcctct gagcctgcga ccagaagcct gccggccagc agcaggagga     1620

gcagtgcaca ccagaggcct ggacttcgcc tgtgatttct ttatccccct gctggtggtc     1680

attctgttcg ccgtggacac tgggctgttt atctccaccc agcagcaggt cacattcctg     1740

ctgaaaatta agcggaccag aaagggcttc cggctgctga atccccatcc taaaccaaac     1800

cccaagaaca atgaa                                                      1815


<210>  51
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27123

<400>  51
atggctcccg caatggagtc ccctacactg ctgtgcgtgg cactgctgtt ctttgcacca       60

gatggcgtgc tggcagaggt ccagctgcag cagtcaggac cagaactgat caaacccgga      120

gcatctgtga aaatgagttg taaggcctca ggctatactt tcacctctta cgtgatgcac      180

tgggtcaagc agaaacctgg acagggcctg gagtggatcg gctatattaa tccatacaac      240

gacgggacca agtacaacga aaagtttaaa ggcaaggcaa cactgactag tgataagagc      300

tcctctactg cttacatgga gctgagttca ctgaccagcg aggactccgc tgtgtactat      360

tgcgcaagag gaacctacta ttacggctct agggtgttcg attactgggg gcagggaacc      420

acactgacag tcagctccgg aggaggaggg tccggaggag gagggtctgg aggcggggga      480

agtgacatcg tgatgacaca ggccgctcct agcattccag tgactcccgg cgagtcagtc      540

agcatctcct gtcggtctag taagagcctg ctgaactcca atggaaacac atatctgtac      600

tggtttctgc agaggcctgg ccagtcccca cagctgctga tctatcgcat gtctaacctg      660

gccagtggcg tgcccgatcg gttctctggc agtgggtcag gaaccgcctt tacactgagg      720

attagccgcg tcgaggctga ggacgtgggg gtctattact gcatgcagca tctggagtac      780

cctttcacat ttggcgccgg gactaaactg gaactgaagc gctcggatcc cggaagcgga      840

ggcagggttg ctatcctttg gcatgaaatg tggcatgagg ggctcgagga ggccagtcgg      900

ctgtacttcg gagaaagaaa tgtgaagggt atgttcgagg tcttggaacc cctgcacgcc      960

atgatggagc gagggcctca aaccctcaag gagacatctt ttaaccaggc atatggtagg     1020

gatctcatgg aagcccagga atggtgcaga aaatacatga aatccggcaa cgtgaaggac     1080

ctgactcagg cttgggacct gtattaccac gtatttcggc gcattggcag cgaagcagcg     1140

gctcgcgaag ctgcagcgcg agaggctgct gcccgggagg cggctgcacg gggcgtgcaa     1200

gtcgagacta tttcaccagg cgacggtaga acttttccaa aacggggtca gacctgcgtc     1260

gttcattaca caggcatgct cgaggatggc aagaagtttg actctagtag ggatcgtaac     1320

aaacccttca agttcatgct gggtaagcag gaggtgatcc gcggctggga ggaaggggtg     1380

gcacagatgt ctgtgggaca gcgagccaag ctgaccatca gccctgatta tgcttacgga     1440

gccaccgggc accccggtat catacctccc cacgctacac tggttttcga cgtagaactc     1500

cttaaattgg aaggcagcgg ggctcccact accacaccag ctccacgacc acctactcct     1560

gcaccaacca ttgcttcaca gcctctgagc ctgcgaccag aagcctgccg gccagcagca     1620

ggaggagcag tgcacaccag aggcctggac ttcgcctgtg atttctttat ccccctgctg     1680

gtggtcattc tgttcgccgt ggacactggg ctgtttatct ccacccagca gcaggtcaca     1740

ttcctgctga aaattaagcg gaccagaaag ggcttccggc tgctgaatcc ccatcctaaa     1800

ccaaacccca agaacaatga a                                               1821


<210>  52
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26563 (encoded amino acid sequence)

<400>  52

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
385                 390                 395                 400 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                405                 410                 415     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            420                 425                 430         


Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe 
        435                 440                 445             


Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe 
    450                 455                 460                 


Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro 
465                 470                 475                 480 


His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
                485                 490 


<210>  53
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26564 (encoded amino acid sequence)

<400>  53

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        275                 280                 285             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    290                 295                 300                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
305                 310                 315                 320 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                325                 330                 335     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            340                 345                 350         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        355                 360                 365             


Tyr His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro 
    370                 375                 380                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
385                 390                 395                 400 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                405                 410                 415     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val 
            420                 425                 430         


Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln 
        435                 440                 445             


Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg 
    450                 455                 460                 


Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
465                 470                 475             


<210>  54
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS26881 (encoded amino acid sequence)

<400>  54

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala 
385                 390                 395                 400 


Ala Arg Glu Ala Ala Ala Arg Gly Arg Val Ala Ile Leu Trp His Glu 
                405                 410                 415     


Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu 
            420                 425                 430         


Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met 
        435                 440                 445             


Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala 
    450                 455                 460                 


Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met 
465                 470                 475                 480 


Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr Tyr 
                485                 490                 495     


His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala 
            500                 505                 510         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        515                 520                 525             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    530                 535                 540                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val Val 
545                 550                 555                 560 


Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln Gln 
                565                 570                 575     


Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg Leu 
            580                 585                 590         


Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
        595                 600                 605 


<210>  55
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27123 (encoded amino acid sequence)

<400>  55

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Arg Val Ala Ile Leu Trp His 
        275                 280                 285             


Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
    290                 295                 300                 


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
305                 310                 315                 320 


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
                325                 330                 335     


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
            340                 345                 350         


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
        355                 360                 365             


Tyr His Val Phe Arg Arg Ile Gly Ser Glu Ala Ala Ala Arg Glu Ala 
    370                 375                 380                 


Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly Val Gln 
385                 390                 395                 400 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
                405                 410                 415     


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
            420                 425                 430         


Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
        435                 440                 445             


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
    450                 455                 460                 


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
465                 470                 475                 480 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                485                 490                 495     


Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ala Pro Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu 
545                 550                 555                 560 


Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln 
                565                 570                 575     


Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe 
            580                 585                 590         


Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
        595                 600                 605         


<210>  56
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (alpha-chain forward)

<400>  56
gcatcgtaat acgactcact atagggcagg ccaccatggc tcccgcaatg gagtc            55


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (alpha-chain reverse)

<400>  57
tcaattgttc ttggggtttg gt                                                22


<210>  58
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (beta-chain forward)

<400>  58
gcatcgtaat acgactcact atagggcagg ccaccatgga cactgagtct aacc             54


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (beta-chain reverse)

<400>  59
tcacagctca cagcctcctt                                                   20


<210>  60
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (gamma-chain forward)

<400>  60
gcatcgtaat acgactcact atagggcagg ccaccatgat cccagccgtg gtcct            55


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer (gamma-chain reverse)

<400>  61
tcagcgaggg ggcagggcct                                                   20


<210>  62
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP-FRB* domain including a four-EAAAR- linker; FRB* refers to a
       variant of FRB having the T2098L mutation (SEQ ID NO: 4)

<400>  62

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu Ala Ala Ala Arg 
            100                 105                 110         


Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly 
        115                 120                 125             


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
    130                 135                 140                 


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
145                 150                 155                 160 


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
                165                 170                 175     


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
            180                 185                 190         


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
        195                 200                 205             


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
    210                 215                 220         


<210>  63
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27039

<400>  63
atggctcccg caatggagtc ccctacactg ctgtgcgtgg cactgctgtt ctttgcacca       60

gatggcgtgc tggcagaggt ccagctgcag cagtcaggac cagaactgat caaacccgga      120

gcatctgtga aaatgagttg taaggcctca ggctatactt tcacctctta cgtgatgcac      180

tgggtcaagc agaaacctgg acagggcctg gagtggatcg gctatattaa tccatacaac      240

gacgggacca agtacaacga aaagtttaaa ggcaaggcaa cactgactag tgataagagc      300

tcctctactg cttacatgga gctgagttca ctgaccagcg aggactccgc tgtgtactat      360

tgcgcaagag gaacctacta ttacggctct agggtgttcg attactgggg gcagggaacc      420

acactgacag tcagctccgg aggaggaggg tccggaggag gagggtctgg aggcggggga      480

agtgacatcg tgatgacaca ggccgctcct agcattccag tgactcccgg cgagtcagtc      540

agcatctcct gtcggtctag taagagcctg ctgaactcca atggaaacac atatctgtac      600

tggtttctgc agaggcctgg ccagtcccca cagctgctga tctatcgcat gtctaacctg      660

gccagtggcg tgcccgatcg gttctctggc agtgggtcag gaaccgcctt tacactgagg      720

attagccgcg tcgaggctga ggacgtgggg gtctattact gcatgcagca tctggagtac      780

cctttcacat ttggcgccgg gactaaactg gaactgaagc gctcggatcc cggaagcgga      840

ggcgtgcaag tcgagactat ttcaccaggc gacggtagaa cttttccaaa acggggtcag      900

acctgcgtcg ttcattacac aggcatgctc gaggatggca agaagtttga ctctagtagg      960

gatcgtaaca aacccttcaa gttcatgctg ggtaagcagg aggtgatccg cggctgggag     1020

gaaggggtgg cacagatgtc tgtgggacag cgagccaagc tgaccatcag ccctgattat     1080

gcttacggag ccaccgggca ccccggtatc atacctcccc acgctacact ggttttcgac     1140

gtagaactcc ttaaattgga agaagcagcg gctcgcgaag ctgcagcgcg agaggctgct     1200

gcccgggagg cggctgcacg gggcagggtt gctatccttt ggcatgaaat gtggcatgag     1260

gggctcgagg aggccagtcg gctgtacttc ggagaaagaa atgtgaaggg tatgttcgag     1320

gtcttggaac ccctgcacgc catgatggag cgagggcctc aaaccctcaa ggagacatct     1380

tttaaccagg catatggtag ggatctcatg gaagcccagg aatggtgcag aaaatacatg     1440

aaatccggca acgtgaagga cctgctccag gcttgggacc tgtattacca cgtatttcgg     1500

cgcattggca gcggggctcc cactaccaca ccagctccac gaccacctac tcctgcacca     1560

accattgctt cacagcctct gagcctgcga ccagaagcct gccggccagc agcaggagga     1620

gcagtgcaca ccagaggcct ggacttcgcc tgtgatttct ttatccccct gctggtggtc     1680

attctgttcg ccgtggacac tgggctgttt atctccaccc agcagcaggt cacattcctg     1740

ctgaaaatta agcggaccag aaagggcttc cggctgctga atccccatcc taaaccaaac     1800

cccaagaaca atgaa                                                      1815


<210>  64
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27039 (encoded amino acid sequence)

<400>  64

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro Gly Ser Gly Gly Val Gln Val Glu Thr Ile Ser 
        275                 280                 285             


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
    290                 295                 300                 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
305                 310                 315                 320 


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
                325                 330                 335     


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
            340                 345                 350         


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
        355                 360                 365             


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
    370                 375                 380                 


Lys Leu Glu Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala 
385                 390                 395                 400 


Ala Arg Glu Ala Ala Ala Arg Gly Arg Val Ala Ile Leu Trp His Glu 
                405                 410                 415     


Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu 
            420                 425                 430         


Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met 
        435                 440                 445             


Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala 
    450                 455                 460                 


Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met 
465                 470                 475                 480 


Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr 
                485                 490                 495     


His Val Phe Arg Arg Ile Gly Ser Gly Ala Pro Thr Thr Thr Pro Ala 
            500                 505                 510         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        515                 520                 525             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    530                 535                 540                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Phe Ile Pro Leu Leu Val Val 
545                 550                 555                 560 


Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile Ser Thr Gln Gln Gln 
                565                 570                 575     


Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg Lys Gly Phe Arg Leu 
            580                 585                 590         


Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn Asn Glu 
        595                 600                 605 


<210>  65
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27572

<400>  65
atggctctgc ctgtcaccgc cctgctgctg cctctggccc tgctgctgca cgccgcacgc       60

cctcagattc agctggtcca gtccgggcct gagctgaaga aaccaggcga aaccgtgaag      120

atctcttgca aagctagtgg atacattttc acaaactatg gcatgaattg ggtcaagcag      180

gccccaggga agagctttaa atggatggga tggatcaaca cttacaccgg cgagagtacc      240

tattcagctg acttcaaggg ccgcttcgca ttttccctgg aaacctcagc aagcacagcc      300

tacctgcaca ttaacgacct gaagaacgag gatacagcta cttacttctg cgcacgatcc      360

ggaggatacg acccaatgga ttattggggc caggggacat ctgtgactgt cagctccgga      420

ggaggaggat ccggcggagg aggctctggg ggaggcggga gtgacatcgt gctgactcag      480

agcccagctt ccctggcagt ctcactggga cagcgcgcaa ccattagctg tcgagcctcc      540

gagtctgtgg ataactacgg caatacattc atgcattggt atcagcagaa gcctgggcag      600

ccccctaaac tgctgatcta ccgcgcctca aatctggaaa gcggcattcc agctcgcttc      660

agtggatcag gcagccggac tgactttacc ctgacaatca accccgtgga ggcagacgat      720

gtcgccacct actattgcca gcagagtaat gaggatccac ccacttttgg ggcaggaacc      780

aagctggaac tgaaacgatc ggatcccgga agcggaggcg tgcaagtcga gactatttca      840

ccaggcgacg gtagaacttt tccaaaacgg ggtcagacct gcgtcgttca ttacacaggc      900

atgctcgagg atggcaagaa gtttgactct agtagggatc gtaacaaacc cttcaagttc      960

atgctgggta agcaggaggt gatccgcggc tgggaggaag gggtggcaca gatgtctgtg     1020

ggacagcgag ccaagctgac catcagccct gattatgctt acggagccac cgggcacccc     1080

ggtatcatac ctccccacgc tacactggtt ttcgacgtag aactccttaa attggaagaa     1140

gcagcggctc gcgaagctgc agcgcgagag gctgctgccc gggaggcggc tgcacggggc     1200

agggttgcta tcctttggca tgaaatgtgg catgaggggc tcgaggaggc cagtcggctg     1260

tacttcggag aaagaaatgt gaagggtatg ttcgaggtct tggaacccct gcacgccatg     1320

atggagcgag ggcctcaaac cctcaaggag acatctttta accaggcata tggtagggat     1380

ctcatggaag cccaggaatg gtgcagaaaa tacatgaaat ccggcaacgt gaaggacctg     1440

ctccaggctt gggacctgta ttaccacgta tttcggcgca ttggcagcgg ggctcccacc     1500

acaacccccg ctccaaggcc ccctaccccc gcaccaacta ttgcctccca gccactctca     1560

ctgcggcctg aggcctgtcg gcccgctgct ggaggcgcag tgcatacaag gggcctcgat     1620

ttcgcctgcg atatttacat ctgggcaccc ctcgccggca cctgcggggt gcttctcctc     1680

tccctggtga ttaccctgta ttgcagacgg ggccggaaga agctcctcta catttttaag     1740

cagcctttca tgcggccagt gcagacaacc caagaggagg atgggtgttc ctgcagattc     1800

cctgaggaag aggaaggcgg gtgcgagctg agagtgaagt tctccaggag cgcagatgcc     1860

cccgcctatc aacagggcca gaaccagctc tacaacgagc ttaacctcgg gaggcgcgaa     1920

gaatacgacg tgttggataa gagaaggggg cgggaccccg agatgggagg aaagccccgg     1980

aggaagaacc ctcaggaggg cctgtacaac gagctgcaga aggataagat ggccgaggcc     2040

tactcagaga tcgggatgaa gggggagcgg cgccgcggga aggggcacga tgggctctac     2100

caggggctga gcacagccac aaaggacaca tacgacgcct tgcacatgca ggcccttcca     2160

ccccgggaa                                                             2169


<210>  66
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27603

<400>  66
atggctctgc ctgtcaccgc cctgctgctg cctctggccc tgctgctgca cgccgcacgc       60

cctcagattc agctggtcca gtccgggcct gagctgaaga aaccaggcga aaccgtgaag      120

atctcttgca aagctagtgg atacattttc acaaactatg gcatgaattg ggtcaagcag      180

gccccaggga agagctttaa atggatggga tggatcaaca cttacaccgg cgagagtacc      240

tattcagctg acttcaaggg ccgcttcgca ttttccctgg aaacctcagc aagcacagcc      300

tacctgcaca ttaacgacct gaagaacgag gatacagcta cttacttctg cgcacgatcc      360

ggaggatacg acccaatgga ttattggggc caggggacat ctgtgactgt cagctccgga      420

ggaggaggat ccggcggagg aggctctggg ggaggcggga gtgacatcgt gctgactcag      480

agcccagctt ccctggcagt ctcactggga cagcgcgcaa ccattagctg tcgagcctcc      540

gagtctgtgg ataactacgg caatacattc atgcattggt atcagcagaa gcctgggcag      600

ccccctaaac tgctgatcta ccgcgcctca aatctggaaa gcggcattcc agctcgcttc      660

agtggatcag gcagccggac tgactttacc ctgacaatca accccgtgga ggcagacgat      720

gtcgccacct actattgcca gcagagtaat gaggatccac ccacttttgg ggcaggaacc      780

aagctggaac tgaaacgatc ggatcccgga agcggaggcg tgcaagtcga gactatttca      840

ccaggcgacg gtagaacttt tccaaaacgg ggtcagacct gcgtcgttca ttacacaggc      900

atgctcgagg atggcaagaa gtttgactct agtagggatc gtaacaaacc cttcaagttc      960

atgctgggta agcaggaggt gatccgcggc tgggaggaag gggtggcaca gatgtctgtg     1020

ggacagcgag ccaagctgac catcagccct gattatgctt acggagccac cgggcacccc     1080

ggtatcatac ctccccacgc tacactggtt ttcgacgtag aactccttaa attggaaggc     1140

agcggggctc ccaccacaac ccccgctcca aggcccccta cccccgcacc aactattgcc     1200

tcccagccac tctcactgcg gcctgaggcc tgtcggcccg ctgctggagg cgcagtgcat     1260

acaaggggcc tcgatttcgc ctgcgatatt tacatctggg cacccctcgc cggcacctgc     1320

ggggtgcttc tcctctccct ggtgattacc ctgtattgca gacggggccg gaagaagctc     1380

ctctacattt ttaagcagcc tttcatgcgg ccagtgcaga caacccaaga ggaggatggg     1440

tgttcctgca gattccctga ggaagaggaa ggcgggtgcg agctgagagt gaagttctcc     1500

aggagcgcag atgcccccgc ctatcaacag ggccagaacc agctctacaa cgagcttaac     1560

ctcgggaggc gcgaagaata cgacgtgttg gataagagaa gggggcggga ccccgagatg     1620

ggaggaaagc cccggaggaa gaaccctcag gagggcctgt acaacgagct gcagaaggat     1680

aagatggccg aggcctactc agagatcggg atgaaggggg agcggcgccg cgggaagggg     1740

cacgatgggc tctaccaggg gctgagcaca gccacaaagg acacatacga cgccttgcac     1800

atgcaggccc ttccaccccg ggaa                                            1824


<210>  67
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27604

<400>  67
atggctctgc ctgtcaccgc cctgctgctg cctctggccc tgctgctgca cgccgcacgc       60

cctcagattc agctggtcca gtccgggcct gagctgaaga aaccaggcga aaccgtgaag      120

atctcttgca aagctagtgg atacattttc acaaactatg gcatgaattg ggtcaagcag      180

gccccaggga agagctttaa atggatggga tggatcaaca cttacaccgg cgagagtacc      240

tattcagctg acttcaaggg ccgcttcgca ttttccctgg aaacctcagc aagcacagcc      300

tacctgcaca ttaacgacct gaagaacgag gatacagcta cttacttctg cgcacgatcc      360

ggaggatacg acccaatgga ttattggggc caggggacat ctgtgactgt cagctccgga      420

ggaggaggat ccggcggagg aggctctggg ggaggcggga gtgacatcgt gctgactcag      480

agcccagctt ccctggcagt ctcactggga cagcgcgcaa ccattagctg tcgagcctcc      540

gagtctgtgg ataactacgg caatacattc atgcattggt atcagcagaa gcctgggcag      600

ccccctaaac tgctgatcta ccgcgcctca aatctggaaa gcggcattcc agctcgcttc      660

agtggatcag gcagccggac tgactttacc ctgacaatca accccgtgga ggcagacgat      720

gtcgccacct actattgcca gcagagtaat gaggatccac ccacttttgg ggcaggaacc      780

aagctggaac tgaaacgatc ggatcccgga agcggaggca gggttgctat cctttggcat      840

gaaatgtggc atgaggggct cgaggaggcc agtcggctgt acttcggaga aagaaatgtg      900

aagggtatgt tcgaggtctt ggaacccctg cacgccatga tggagcgagg gcctcaaacc      960

ctcaaggaga catcttttaa ccaggcatat ggtagggatc tcatggaagc ccaggaatgg     1020

tgcagaaaat acatgaaatc cggcaacgtg aaggacctgc tccaggcttg ggacctgtat     1080

taccacgtat ttcggcgcat tggcagcggg gctcccacca caacccccgc tccaaggccc     1140

cctacccccg caccaactat tgcctcccag ccactctcac tgcggcctga ggcctgtcgg     1200

cccgctgctg gaggcgcagt gcatacaagg ggcctcgatt tcgcctgcga tatttacatc     1260

tgggcacccc tcgccggcac ctgcggggtg cttctcctct ccctggtgat taccctgtat     1320

tgcagacggg gccggaagaa gctcctctac atttttaagc agcctttcat gcggccagtg     1380

cagacaaccc aagaggagga tgggtgttcc tgcagattcc ctgaggaaga ggaaggcggg     1440

tgcgagctga gagtgaagtt ctccaggagc gcagatgccc ccgcctatca acagggccag     1500

aaccagctct acaacgagct taacctcggg aggcgcgaag aatacgacgt gttggataag     1560

agaagggggc gggaccccga gatgggagga aagccccgga ggaagaaccc tcaggagggc     1620

ctgtacaacg agctgcagaa ggataagatg gccgaggcct actcagagat cgggatgaag     1680

ggggagcggc gccgcgggaa ggggcacgat gggctctacc aggggctgag cacagccaca     1740

aaggacacat acgacgcctt gcacatgcag gcccttccac cccgggaa                  1788


<210>  68
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27572 (encoded amino acid sequence)

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        275                 280                 285             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    290                 295                 300                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
305                 310                 315                 320 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                325                 330                 335     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            340                 345                 350         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        355                 360                 365             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Glu Ala Ala Ala Arg 
    370                 375                 380                 


Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly 
385                 390                 395                 400 


Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
                405                 410                 415     


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            420                 425                 430         


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        435                 440                 445             


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    450                 455                 460                 


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
465                 470                 475                 480 


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly Ser 
                485                 490                 495     


Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            500                 505                 510         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        515                 520                 525             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    530                 535                 540                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
545                 550                 555                 560 


Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu Leu 
                565                 570                 575     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            580                 585                 590         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        595                 600                 605             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    610                 615                 620                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
625                 630                 635                 640 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                645                 650                 655     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            660                 665                 670         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        675                 680                 685             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    690                 695                 700                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
705                 710                 715                 720 


Pro Arg Glu 
            


<210>  69
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27603 (encoded amino acid sequence)

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        275                 280                 285             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    290                 295                 300                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
305                 310                 315                 320 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                325                 330                 335     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            340                 345                 350         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        355                 360                 365             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly Ala Pro 
    370                 375                 380                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
385                 390                 395                 400 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                405                 410                 415     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            420                 425                 430         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        435                 440                 445             


Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    450                 455                 460                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
465                 470                 475                 480 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                485                 490                 495     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            500                 505                 510         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        515                 520                 525             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    530                 535                 540                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
545                 550                 555                 560 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                565                 570                 575     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            580                 585                 590         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu 
        595                 600                 605             


<210>  70
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct pCLS27604 (encoded amino acid sequence)

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
                165                 170                 175     


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
        195                 200                 205             


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro Gly Ser Gly 
            260                 265                 270         


Gly Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
        275                 280                 285             


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
    290                 295                 300                 


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
305                 310                 315                 320 


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
                325                 330                 335     


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
            340                 345                 350         


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Gly 
        355                 360                 365             


Ser Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    370                 375                 380                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
385                 390                 395                 400 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                405                 410                 415     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            420                 425                 430         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Arg Gly Arg Lys Lys Leu 
        435                 440                 445             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    450                 455                 460                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
465                 470                 475                 480 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                485                 490                 495     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            500                 505                 510         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        515                 520                 525             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    530                 535                 540                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
545                 550                 555                 560 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                565                 570                 575     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            580                 585                 590         


Pro Pro Arg Glu 
        595     


<210>  71
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide scCAR-F

<400>  71
gcatcgtaat acgactcact atagggcagg ccaccatggc tttgcctgtc actgcc           56


<210>  72
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide scCAR-R

<400>  72
ctagaggatc gctcgagtta ggtctc                                            26


