                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL
      LADIWALA, Asif
      MCKAY, Patrick A.
      FONG, Chris B.
 
<120> PURIFICATION OF FKPA AND USES THEREOF FOR PRODUCING RECOMBINANT 
      POLYPEPTIDES

<130> P32953-WO

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150> 62/210,378
<151> 2015-08-26

<150> 62/207,910
<151> 2015-08-20

<150> 62/207,908
<151> 2015-08-20

<160> 45    

<170> PatentIn version 3.5

<210> 1
<211> 185
<212> PRT
<213> Escherichia coli

<400> 1
Ala Phe Ala Asp Lys Ser Lys Leu Ser Asp Gln Glu Ile Glu Gln Thr 
1               5                   10                  15      


Leu Gln Ala Phe Glu Ala Arg Val Lys Ser Ser Ala Gln Ala Lys Met 
            20                  25                  30          


Glu Lys Asp Ala Ala Asp Asn Glu Ala Lys Gly Lys Glu Tyr Arg Glu 
        35                  40                  45              


Lys Phe Ala Lys Glu Lys Gly Val Lys Thr Ser Ser Thr Gly Leu Val 
    50                  55                  60                  


Tyr Gln Val Val Glu Ala Gly Lys Gly Glu Ala Pro Lys Asp Ser Asp 
65                  70                  75                  80  


Thr Val Val Val Asn Tyr Lys Gly Thr Leu Ile Asp Gly Lys Glu Phe 
                85                  90                  95      


Asp Asn Ser Tyr Thr Arg Gly Glu Pro Leu Ser Phe Arg Leu Asp Gly 
            100                 105                 110         


Val Ile Pro Gly Trp Thr Glu Gly Leu Lys Asn Ile Lys Lys Gly Gly 
        115                 120                 125             


Lys Ile Lys Leu Val Ile Pro Pro Glu Leu Ala Tyr Gly Lys Ala Gly 
    130                 135                 140                 


Val Pro Gly Ile Pro Pro Asn Ser Thr Leu Val Phe Asp Val Glu Leu 
145                 150                 155                 160 


Leu Asp Val Lys Pro Ala Pro Lys Ala Asp Ala Lys Pro Glu Ala Asp 
                165                 170                 175     


Ala Lys Ala Ala Asp Ser Ala Lys Lys 
            180                 185 


<210> 2
<211> 270
<212> PRT
<213> Escherichia coli


<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<400> 2
Met Lys Ser Leu Phe Lys Val Thr Leu Leu Ala Thr Thr Met Ala Val 
1               5                   10                  15      


Ala Leu His Ala Pro Ile Thr Phe Ala Ala Glu Ala Ala Lys Pro Ala 
            20                  25                  30          


Thr Thr Ala Asp Ser Lys Ala Ala Phe Lys Asn Asp Asp Gln Lys Ser 
        35                  40                  45              


Ala Tyr Ala Leu Gly Ala Ser Leu Gly Arg Tyr Met Glu Asn Ser Leu 
    50                  55                  60                  


Lys Glu Gln Glu Lys Leu Gly Ile Lys Leu Asp Lys Asp Gln Leu Ile 
65                  70                  75                  80  


Ala Gly Val Gln Asp Ala Phe Ala Asp Lys Ser Lys Leu Ser Asp Gln 
                85                  90                  95      


Glu Ile Glu Gln Thr Leu Gln Ala Phe Glu Ala Arg Val Lys Ser Ser 
            100                 105                 110         


Ala Gln Ala Lys Met Glu Lys Asp Ala Ala Asp Asn Glu Ala Lys Gly 
        115                 120                 125             


Lys Glu Tyr Arg Glu Lys Phe Ala Lys Glu Lys Gly Val Lys Thr Ser 
    130                 135                 140                 


Ser Thr Gly Leu Val Tyr Gln Val Val Glu Ala Gly Lys Gly Glu Ala 
145                 150                 155                 160 


Pro Lys Asp Ser Asp Thr Val Val Val Asn Tyr Lys Gly Thr Leu Ile 
                165                 170                 175     


Asp Gly Lys Glu Phe Asp Asn Ser Tyr Thr Arg Gly Glu Pro Leu Ser 
            180                 185                 190         


Phe Arg Leu Asp Gly Val Ile Pro Gly Trp Thr Glu Gly Leu Lys Asn 
        195                 200                 205             


Ile Lys Lys Gly Gly Lys Ile Lys Leu Val Ile Pro Pro Glu Leu Ala 
    210                 215                 220                 


Tyr Gly Lys Ala Gly Val Pro Gly Ile Pro Pro Asn Ser Thr Xaa Val 
225                 230                 235                 240 


Phe Asp Val Glu Leu Leu Asp Val Lys Pro Ala Pro Lys Ala Asp Ala 
                245                 250                 255     


Lys Pro Glu Ala Asp Ala Lys Ala Ala Asp Ser Ala Lys Lys 
            260                 265                 270 


<210> 3
<211> 813
<212> DNA
<213> Escherichia coli

<400> 3
atgaaatcac tgtttaaagt aacgctgctg gcgaccacaa tggccgttgc cctgcatgca       60

ccaatcactt ttgctgctga agctgcaaaa cctgctacag ctgctgacag caaagcagcg      120

ttcaaaaatg acgatcagaa atcagcttat gcactgggtg cctcgctggg tcgttacatg      180

gaaaactctc taaaagaaca agaaaaactg ggcatcaaac tggataaaga tcagctgatc      240

gctggtgttc aggatgcatt tgctgataag agcaaactct ccgaccaaga gatcgaacag      300

actctacaag cattcgaagc tcgcgtgaag tcttctgctc aggcgaagat ggaaaaagac      360

gcggctgata acgaagcaaa aggtaaagag taccgcgaga aatttgccaa agagaaaggt      420

gtgaaaacct cttcaactgg tctggtttat caggtagtag aagccggtaa aggcgaagca      480

ccgaaagaca gcgatactgt tgtagtgaac tacaaaggta cgctgatcga cggtaaagag      540

ttcgacaact cttacacccg tggtgaaccg ctttctttcc gtctggacgg tgttatcccg      600

ggttggacag aaggtctgaa gaacatcaag aaaggcggta agatcaaact ggttattcca      660

ccagaactgg cttacggcaa agcgggtgtt ccggggatcc caccgaattc taccctggtg      720

tttgacgtag agctgctgga tgtgaaacca gcgccgaagg ctgatgcaaa gccggaagct      780

gatgcgaaag ccgcagattc tgctaaaaaa taa                                   813


<210> 4
<211> 132
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Arg Phe Asn 
    130         


<210> 5
<211> 114
<212> PRT
<213> Homo sapiens

<400> 5
Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
            100                 105                 110         


Phe Asn 
        


<210> 6
<211> 155
<212> PRT
<213> Homo sapiens

<400> 6
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210> 7
<211> 132
<212> PRT
<213> Homo sapiens

<400> 7
Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210> 8
<211> 163
<212> PRT
<213> Homo sapiens

<400> 8
Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210> 9
<211> 133
<212> PRT
<213> Homo sapiens

<400> 9
Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210> 10
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 10
Glu Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 11
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 11
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 12
Ala Tyr Ser Val Asn 
1               5   


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 13
Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 14
Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn 
1               5                   10  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 15
Arg Ala Ser Lys Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 16
Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 17
Gln Gln Asn Asn Glu Asp Pro Arg Thr 
1               5                   


<210> 18
<211> 444
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 18
Glu Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210> 19
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 19
Glu Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210> 20
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 20
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 21
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Gly Phe Gly Glu Phe Tyr Trp Asn Phe Gly Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 22
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 22
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 23
Asp Tyr Ala Met His 
1               5   


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 24
Gly Ile Asn Trp Ser Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 25
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 25
Asp Ile Gly Gly Phe Gly Glu Phe Tyr Trp Asn Phe Gly Leu 
1               5                   10                  


<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 26
Arg Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala 
1               5                   10      


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 27
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 28
Gln Gln Arg Ser Asn Trp Pro Pro Ala Thr 
1               5                   10  


<210> 29
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Gly Phe Gly Glu Phe Tyr Trp Asn Phe Gly Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210> 30
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Gly Phe Gly Glu Phe Tyr Trp Asn Phe Gly Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210> 31
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 31
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 32
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 32
gaagttaccc tgcgcgagag cggcccagcc ctggtgaagc caacccagac cctgaccctg       60

acctgcaccg tcagcggctt cagcctgagc gcctacagcg tgaactggat ccgccagcca      120

ccaggcaagg ccctggagtg gctggccatg atctggggcg acggcaagat cgtgtacaac      180

agcgccctga agagccgcct gaccatcagc aaggacacca gcaagaacca ggtggtgctg      240

accatgacca acatggaccc agtggacacc gccacctact actgcgccgg cgacggctac      300

tacccatacg ccatggacaa ctggggccag ggcagcctgg tgaccgtgag cagc            354


<210> 33
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 33
gatatcgtgc tgacccagag cccagacagc ctgtctgtga gcctgggcga gcgcgccacc       60

atcaactgcc gcgccagcaa aagcgtggac agctacggca acagcttcat gcactggtat      120

cagcagaagc caggccagcc acccaagctg ctgatctacc tggccagcaa cctggagagc      180

ggcgtgccag accgcttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc      240

tctctgcagg ccgaggatgt ggccgtgtac tactgccagc agaacaacga ggacccacgc      300

accttcggtg gcggtaccaa ggtggagatc aaa                                   333


<210> 34
<211> 1332
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 34
gaagttaccc tgcgcgagag cggcccagcc ctggtgaagc caacccagac cctgaccctg       60

acctgcaccg tcagcggctt cagcctgagc gcctacagcg tgaactggat ccgccagcca      120

ccaggcaagg ccctggagtg gctggccatg atctggggcg acggcaagat cgtgtacaac      180

agcgccctga agagccgcct gaccatcagc aaggacacca gcaagaacca ggtggtgctg      240

accatgacca acatggaccc agtggacacc gccacctact actgcgccgg cgacggctac      300

tacccatacg ccatggacaa ctggggccag ggcagcctgg tgaccgtgag cagcgcttcc      360

accaagggcc catcggtctt ccccctggca ccctgctccc gcagtacttc tgagtccaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gactgtgccc tctagcagct tgggcaccaa gacctacacg      600

tgcaacgtgg atcacaagcc cagcaacacc aaggtggaca aacgcgttga gtccaaatat      660

ggtcccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctgt ggtgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gt                                                         1332


<210> 35
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 35
gaagttaccc tgcgcgagag cggcccagcc ctggtgaagc caacccagac cctgaccctg       60

acctgcaccg tcagcggctt cagcctgagc gcctacagcg tgaactggat ccgccagcca      120

ccaggcaagg ccctggagtg gctggccatg atctggggcg acggcaagat cgtgtacaac      180

agcgccctga agagccgcct gaccatcagc aaggacacca gcaagaacca ggtggtgctg      240

accatgacca acatggaccc agtggacacc gccacctact actgcgccgg cgacggctac      300

tacccatacg ccatggacaa ctggggccag ggcagcctgg tgaccgtgag cagcgcttcc      360

accaagggcc catcggtctt ccccctggca ccctgctccc gcagtacttc tgagtccaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gactgtgccc tctagcagct tgggcaccaa gacctacacg      600

tgcaacgtgg atcacaagcc cagcaacacc aaggtggaca aacgcgttga gtccaaatat      660

ggtcccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctgt ggtgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaataa                                                   1338


<210> 36
<211> 657
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 36
gatatcgtgc tgacccagag cccagacagc ctgtctgtga gcctgggcga gcgcgccacc       60

atcaactgcc gcgccagcaa aagcgtggac agctacggca acagcttcat gcactggtat      120

cagcagaagc caggccagcc acccaagctg ctgatctacc tggccagcaa cctggagagc      180

ggcgtgccag accgcttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc      240

tctctgcagg ccgaggatgt ggccgtgtac tactgccagc agaacaacga ggacccacgc      300

accttcggtg gcggtaccaa ggtggagatc aaacgaactg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cttctgttgt gtgcctgctg      420

aataacttct atccccgtga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaa         657


<210> 37
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 37
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attaattgga gcagtggtgg cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aagagatatc      300

ggggggttcg gggagtttta ctggaacttc ggtctctggg gccgtggcac cctggtcact      360

gtctcctca                                                              369


<210> 38
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 38
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaga agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccggc cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210> 39
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 39
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attaattgga gcagtggtgg cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aagagatatc      300

ggggggttcg gggagtttta ctggaacttc ggtctctggg gccgtggcac cctggtcact      360

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctg ctcccgcagt      420

acttctgagt ccacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgactg tgccctctag cagcttgggc      600

accaagacct acacgtgcaa cgtggatcac aagcccagca acaccaaggt ggacaaacgc      660

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgagctgc gctgtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagagcc tctccctgtc tctgggt                                         1347


<210> 40
<211> 1353
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 40
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attaattgga gcagtggtgg cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aagagatatc      300

ggggggttcg gggagtttta ctggaacttc ggtctctggg gccgtggcac cctggtcact      360

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctg ctcccgcagt      420

acttctgagt ccacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgactg tgccctctag cagcttgggc      600

accaagacct acacgtgcaa cgtggatcac aagcccagca acaccaaggt ggacaaacgc      660

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgagctgc gctgtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagagcc tctccctgtc tctgggtaaa taa                                  1353


<210> 41
<211> 648
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 41
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaga agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccggc cactttcggc      300

ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcttctgttg tgtgcctgct gaataacttc      420

tatccccgtg aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                   648


<210> 42
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 42
gaagttcagc tggttgaaag cggtggtggt ctggttcagc ctggtcgtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttgat gattatgcca tgcattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcggt attaattgga gcagcggtgg tattggttat      180

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atgccaaaaa tagcctgtac      240

ctgcagatga atagtctgcg tgcagaagat accgcactgt attattgtgc acgtgatatt      300

ggtggttttg gcgaattcta ttggaatttt ggtctgtggg gtcgtggcac cctggttacc      360

gttagcagcg cctccaccaa gggcccatcg gtcttccccc tggcaccctg ctcccgcagt      420

acttctgagt ccacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgactg tgccctctag cagcttgggc      600

accaagacct acacgtgcaa cgtggatcac aagcccagca acaccaaggt ggacaaacgc      660

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgagctgc gctgtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagagcc tctccctgtc tctgggt                                         1347


<210> 43
<211> 1353
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 43
gaagttcagc tggttgaaag cggtggtggt ctggttcagc ctggtcgtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttgat gattatgcca tgcattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcggt attaattgga gcagcggtgg tattggttat      180

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata atgccaaaaa tagcctgtac      240

ctgcagatga atagtctgcg tgcagaagat accgcactgt attattgtgc acgtgatatt      300

ggtggttttg gcgaattcta ttggaatttt ggtctgtggg gtcgtggcac cctggttacc      360

gttagcagcg cctccaccaa gggcccatcg gtcttccccc tggcaccctg ctcccgcagt      420

acttctgagt ccacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgactg tgccctctag cagcttgggc      600

accaagacct acacgtgcaa cgtggatcac aagcccagca acaccaaggt ggacaaacgc      660

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgagctgc gctgtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtt agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagagcc tctccctgtc tctgggtaaa taa                                  1353


<210> 44
<211> 648
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<400> 44
gaaattgttc tgacccagag tccggcaacc ctgagcctga gtccgggtga acgtgccacc       60

ctgagctgtc gtgcaagcca gagcgttcgt agctatctgg catggtatca gcagaaaccg      120

ggtcaggcac cgcgtctgct gatttatgat gcaagcaatc gtgcaaccgg tattccggca      180

cgttttagcg gtagcggtag tggcaccgat tttaccctga ccattagcag cctggaaccg      240

gaagattttg cagtgtatta ttgtcagcag cgtagcaatt ggccaccggc aacctttggt      300

ggtggcacca aagttgaaat taaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcttctgttg tgtgcctgct gaataacttc      420

tatccccgtg aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                   648


<210> 45
<211> 11
<212> PRT
<213> Escherichia coli

<400> 45
Ser Ala Tyr Ala Leu Gly Ala Ser Leu Gly Arg 
1               5                   10      


