                         SEQUENCE LISTING

<110>  INSERM
 
<120>  NEW METHOD FOR TREATING CANCER

<130>  BIO14341 BORG

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  MINK1 #9

<400>  1
ggaacaaacu gcgggugua                                                  19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  MINK1 #10)

<400>  2
gaaguggucu aagaaguuc                                                  19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  MINK1 #03)

<400>  3
agcggctcaa ggtcatctat g                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  MINK1 #06

<400>  4
gctactgaag tttcccttca t                                               21


<210>  5
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  PRICKLE1 #02

<400>  5
gagagaagca ucggauuaa                                                  19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  PRICKLE1 #04

<400>  6
gaagauaaau ggaggugaa                                                  19


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PRICKLE1 #403

<400>  7
gctcagcatg tgacgagata a                                               21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PRICKLE1 #405

<400>  8
ccaccacatg ataatgaggt a                                               21


<210>  9
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  PRICKLE1 C1 polypeptide

<400>  9

Asp Ser Ser Asp Ser Ala Phe Gln Ser Ala Arg Ser Arg Asp Ser Arg 
1               5                   10                  15      


Arg Ser Val Arg Met Gly Lys Ser Ser Arg Ser Ala Asp Gln Cys Arg 
            20                  25                  30          


Gln Ser Leu Leu Leu Ser Pro Ala Leu Asn Tyr Lys Phe Pro Gly Leu 
        35                  40                  45              


Ser Gly Asn Ala Asp Asp Thr Leu Ser Arg Lys Leu Asp Asp Leu Ser 
    50                  55                  60                  


Leu Ser Arg Gln Gly Thr Ser Phe Ala Ser Glu Glu Phe Trp Lys Gly 
65                  70                  75                  80  


Arg Val Glu Gln Glu Thr Pro Glu Asp Pro Glu Glu Trp Ala Asp His 
                85                  90                  95      


Glu Asp Tyr Met Thr Gln Leu Leu Leu Lys Phe Gly Asp Lys Ser Leu 
            100                 105                 110         


Phe Gln Pro Gln Pro Asn Glu Met Asp Ile Arg Ala Ser Glu His Trp 
        115                 120                 125             


Ile Ser Asp Asn Met Val Lys Ser Lys Thr Glu Leu Lys Gln Asn Asn 
    130                 135                 140                 


Gln Ser Leu Ala Ser Lys Lys Tyr Gln Ser Asp Met Tyr Trp Ala Gln 
145                 150                 155                 160 


Ser Gln Asp Gly Leu Gly Asp Ser Ala Tyr Gly Ser His Pro Gly Pro 
                165                 170                 175     


Ala Ser Ser Arg Arg Leu Gln Glu Leu Glu Leu Asp His Gly Ala Ser 
            180                 185                 190         


Gly Tyr Asn His Asp Glu Thr Gln Trp Tyr Glu Asp Ser Leu Glu Cys 
        195                 200                 205             


Leu Ser Asp Leu Lys Pro Glu Gln Ser Val Arg Asp Ser Met Asp Ser 
    210                 215                 220                 


Leu Ala Leu Ser Asn Ile Thr Gly Ala Ser Val Asp Gly Glu Asn Lys 
225                 230                 235                 240 


Pro Arg 
        


<210>  10
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  PRICKLE1 C1 nucleic acid sequence

<400>  10
gattcttccg actctgcatt tcagtcagct cgatcaagag actcccgaag aagtgtccga     60

atgggcaaga gcagccggtc agcagatcag tgtagacagt ctctcctctt atcgcctgct    120

ctgaactaca agtttcctgg cctctcaggc aatgctgatg acaccctttc tcgaaaattg    180

gatgatctga gtctctccag acaaggaaca agttttgcca gtgaagaatt ttggaaaggc    240

agagtagagc aggaaactcc agaagaccct gaagaatggg ctgatcatga agattatatg    300

acgcagctcc tcctcaagtt tggtgataaa agcctctttc agccacagcc caatgagatg    360

gatattcgag ccagtgagca ctggatatct gataacatgg ttaaaagtaa gaccgagtta    420

aagcaaaata accagagcct tgcaagtaaa aaataccagt ctgatatgta ctgggcacag    480

tcacaagatg gactgggcga ttctgcttat ggcagccacc caggccctgc aagcagtaga    540

aggcttcagg aattggaact ggaccatggg gcttcagggt ataatcatga tgaaacacag    600

tggtatgaag attccctgga gtgtctgtca gacctgaaac cagagcaaag tgttcgggat    660

tcgatggatt ctttggcatt gtccaatatc acaggggctt cggtggatgg agaaaacaag    720

ccaagg                                                               726


<210>  11
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  VENUS polypeptide

<400>  11

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Arg Ala 
225                 230                 235                 240 


Arg Pro 
        


<210>  12
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  VENUS nucleic acid sequence

<400>  12
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac    120

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc    180

ctcgtgacca ccctgggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag    240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc    300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg    360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac    420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac    480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc    540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac    600

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc    660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacagggcg    720

cgccct                                                               726


<210>  13
<211>  484
<212>  PRT
<213>  Artificial

<220>
<223>  VENUS-C1 amino acid sequence

<400>  13

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Arg Ala 
225                 230                 235                 240 


Arg Pro Asp Ser Ser Asp Ser Ala Phe Gln Ser Ala Arg Ser Arg Asp 
                245                 250                 255     


Ser Arg Arg Ser Val Arg Met Gly Lys Ser Ser Arg Ser Ala Asp Gln 
            260                 265                 270         


Cys Arg Gln Ser Leu Leu Leu Ser Pro Ala Leu Asn Tyr Lys Phe Pro 
        275                 280                 285             


Gly Leu Ser Gly Asn Ala Asp Asp Thr Leu Ser Arg Lys Leu Asp Asp 
    290                 295                 300                 


Leu Ser Leu Ser Arg Gln Gly Thr Ser Phe Ala Ser Glu Glu Phe Trp 
305                 310                 315                 320 


Lys Gly Arg Val Glu Gln Glu Thr Pro Glu Asp Pro Glu Glu Trp Ala 
                325                 330                 335     


Asp His Glu Asp Tyr Met Thr Gln Leu Leu Leu Lys Phe Gly Asp Lys 
            340                 345                 350         


Ser Leu Phe Gln Pro Gln Pro Asn Glu Met Asp Ile Arg Ala Ser Glu 
        355                 360                 365             


His Trp Ile Ser Asp Asn Met Val Lys Ser Lys Thr Glu Leu Lys Gln 
    370                 375                 380                 


Asn Asn Gln Ser Leu Ala Ser Lys Lys Tyr Gln Ser Asp Met Tyr Trp 
385                 390                 395                 400 


Ala Gln Ser Gln Asp Gly Leu Gly Asp Ser Ala Tyr Gly Ser His Pro 
                405                 410                 415     


Gly Pro Ala Ser Ser Arg Arg Leu Gln Glu Leu Glu Leu Asp His Gly 
            420                 425                 430         


Ala Ser Gly Tyr Asn His Asp Glu Thr Gln Trp Tyr Glu Asp Ser Leu 
        435                 440                 445             


Glu Cys Leu Ser Asp Leu Lys Pro Glu Gln Ser Val Arg Asp Ser Met 
    450                 455                 460                 


Asp Ser Leu Ala Leu Ser Asn Ile Thr Gly Ala Ser Val Asp Gly Glu 
465                 470                 475                 480 


Asn Lys Pro Arg 
                


<210>  14
<211>  1452
<212>  DNA
<213>  Artificial

<220>
<223>  VENUS-C1 nucleic acid sequence

<400>  14
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac    120

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc    180

ctcgtgacca ccctgggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag    240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc    300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg    360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac    420

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac    480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc    540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac    600

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc    660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacagggcg    720

cgccctgatt cttccgactc tgcatttcag tcagctcgat caagagactc ccgaagaagt    780

gtccgaatgg gcaagagcag ccggtcagca gatcagtgta gacagtctct cctcttatcg    840

cctgctctga actacaagtt tcctggcctc tcaggcaatg ctgatgacac cctttctcga    900

aaattggatg atctgagtct ctccagacaa ggaacaagtt ttgccagtga agaattttgg    960

aaaggcagag tagagcagga aactccagaa gaccctgaag aatgggctga tcatgaagat   1020

tatatgacgc agctcctcct caagtttggt gataaaagcc tctttcagcc acagcccaat   1080

gagatggata ttcgagccag tgagcactgg atatctgata acatggttaa aagtaagacc   1140

gagttaaagc aaaataacca gagccttgca agtaaaaaat accagtctga tatgtactgg   1200

gcacagtcac aagatggact gggcgattct gcttatggca gccacccagg ccctgcaagc   1260

agtagaaggc ttcaggaatt ggaactggac catggggctt cagggtataa tcatgatgaa   1320

acacagtggt atgaagattc cctggagtgt ctgtcagacc tgaaaccaga gcaaagtgtt   1380

cgggattcga tggattcttt ggcattgtcc aatatcacag gggcttcggt ggatggagaa   1440

aacaagccaa gg                                                       1452


