                         SEQUENCE LISTING

<110>  Deutsches Zentrum fr Neurodegenerative Erkrankungen e.V. 
       (DZNE)
 
<120>  Antibody or antibody fragment or non-Ig scaffold binding to a 
       binding region of an anti-N-methyl-D-aspartate (NMDA) receptor 
       antibody

<130>  D75001WO

<150>  EP15181290.6
<151>  2015-08-17

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg His Tyr Asp Phe Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  2
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  3
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Val Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Ser Gly Gly Val Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Glu Ser 
1               5                   10                  15      


Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Phe Trp 
            20                  25                  30          


Ile Gly Trp Val Arg Gln Met Pro Gly Ser Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ala Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Thr 
                85                  90                  95      


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  7
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Gly Val Phe Gly Glu Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Gly Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Ala Asp Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Val Gly Ile Ala Val Thr Gly Tyr Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  10
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Gly Gly Asn His Ser Glu Ser Val His Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp 
        35                  40                  45              


Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Gly Gly Asp Glu 
65                  70                  75                  80  


Ala Glu Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  11
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr 
1               5                   10                  15      


Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
        35                  40                  45              


Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser Tyr Thr Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  13
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Ser Ser Trp Tyr Ala Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  14
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Asp Asp Asn Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Ile Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Arg Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Arg Arg His Tyr Asp Phe Asp Ala Phe Asp Ile 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  19
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Ser 
1           


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val 
1               5                   10      


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Gly Ser Ile Ser Ser Ser Asn Trp 
1               5                   


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Tyr His Ser Gly Asn Thr 
1               5           


<210>  23
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Arg Asp Val Ser Gly Gly Val Asn Trp Phe Asp Pro 
1               5                   10              


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  25
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Asp Asn 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Ser Tyr Asp Ser Ser Thr Val Val 
1               5                   


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Tyr Ser Phe Thr Thr Phe Trp 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  28

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Arg Ser Ala Val Phe Asp Tyr 
1               5               


<210>  30
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Ser Val Ser Ser Asn 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Ala Ser 
1           


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Gln Tyr Asn Asn Trp Pro Thr Ser Trp Thr 
1               5                   10      


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Ile Tyr Pro Gly Asp Ser Asp 
1               5           


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  37
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Val Ser 
1           


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Ser Tyr Ala Gly Ser Tyr Thr Gly Val 
1               5                   10  


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Phe Thr Phe Asp Asp Tyr Gly 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Ile Asn Trp Ser Gly Ala Asp Thr 
1               5               


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Arg Glu Val Gly Ile Ala Val Thr Gly Tyr Trp Phe Asp Pro 
1               5                   10                  15  


<210>  42
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  42

His Ser Glu Ser 
1               


<210>  43
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Asp Ser 
1           


<210>  44
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val Val 
1               5                   10              


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  48
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  49
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Val Ser 
1           


<210>  50
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  50

Cys Ser Tyr Ala Gly Ser Tyr Thr Gly Val 
1               5                   10  


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

Ile Ser Trp Ser Ser Gly Ser Ile 
1               5               


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Lys Asp Arg Ala Ser Ser Trp Tyr Ala Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  55
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  55

Asp Asp Asn 
1           


<210>  56
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Thr Arg Val 
1               5   


