                               SEQUENCE LISTING

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY

<130> 19240.1100 WO1

<140> PCT/US2016/046920
<141> 2016-08-12

<150> 62/354,494
<151> 2016-06-24

<150> 62/204,205
<151> 2015-08-12

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 1791
<212> PRT
<213> Homo sapiens

<400> 1
Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Asp Asp Asn Cys Thr Asp 
                805                 810                 815     


Asn Phe Thr Pro Asn Gln Val Ala Arg Met His Cys Tyr Leu Asp Leu 
            820                 825                 830         


Val Tyr Gln Gln Trp Thr Glu Ser Arg Lys Pro Thr Pro Ile Pro Ile 
        835                 840                 845             


Pro Pro Met Val Ile Gly Gln Thr Asn Lys Ser Leu Thr Ile His Trp 
    850                 855                 860                 


Leu Pro Pro Ile Ser Gly Val Val Tyr Asp Arg Ala Ser Gly Ser Leu 
865                 870                 875                 880 


Cys Gly Ala Cys Thr Glu Asp Gly Thr Phe Arg Gln Tyr Val His Thr 
                885                 890                 895     


Ala Ser Ser Arg Arg Val Cys Asp Ser Ser Gly Tyr Trp Thr Pro Glu 
            900                 905                 910         


Glu Ala Val Gly Pro Pro Asp Val Asp Gln Pro Cys Glu Pro Ser Leu 
        915                 920                 925             


Gln Ala Trp Ser Pro Glu Val His Leu Tyr His Met Asn Met Thr Val 
    930                 935                 940                 


Pro Cys Pro Thr Glu Gly Cys Ser Leu Glu Leu Leu Phe Gln His Pro 
945                 950                 955                 960 


Val Gln Ala Asp Thr Leu Thr Leu Trp Val Thr Ser Phe Phe Met Glu 
                965                 970                 975     


Ser Ser Gln Val Leu Phe Asp Thr Glu Ile Leu Leu Glu Asn Lys Glu 
            980                 985                 990         


Ser Val His Leu Gly Pro Leu Asp  Thr Phe Cys Asp Ile  Pro Leu Thr 
        995                 1000                 1005             


Ile Lys  Leu His Val Asp Gly  Lys Val Ser Gly Val  Lys Val Tyr 
    1010                 1015                 1020             


Thr Phe  Asp Glu Arg Ile Glu  Ile Asp Ala Ala Leu  Leu Thr Ser 
    1025                 1030                 1035             


Gln Pro  His Ser Pro Leu Cys  Ser Gly Cys Arg Pro  Val Arg Tyr 
    1040                 1045                 1050             


Gln Val  Leu Arg Asp Pro Pro  Phe Ala Ser Gly Leu  Pro Val Val 
    1055                 1060                 1065             


Val Thr  His Ser His Arg Lys  Phe Thr Asp Val Glu  Val Thr Pro 
    1070                 1075                 1080             


Gly Gln  Met Tyr Gln Tyr Gln  Val Leu Ala Glu Ala  Gly Gly Glu 
    1085                 1090                 1095             


Leu Gly  Glu Ala Ser Pro Pro  Leu Asn His Ile His  Gly Ala Pro 
    1100                 1105                 1110             


Tyr Cys  Gly Asp Gly Lys Val  Ser Glu Arg Leu Gly  Glu Glu Cys 
    1115                 1120                 1125             


Asp Asp  Gly Asp Leu Val Ser  Gly Asp Gly Cys Ser  Lys Val Cys 
    1130                 1135                 1140             


Glu Leu  Glu Glu Gly Phe Asn  Cys Val Gly Glu Pro  Ser Leu Cys 
    1145                 1150                 1155             


Tyr Met  Tyr Glu Gly Asp Gly  Ile Cys Glu Pro Phe  Glu Arg Lys 
    1160                 1165                 1170             


Thr Ser  Ile Val Asp Cys Gly  Ile Tyr Thr Pro Lys  Gly Tyr Leu 
    1175                 1180                 1185             


Asp Gln  Trp Ala Thr Arg Ala  Tyr Ser Ser His Glu  Asp Lys Lys 
    1190                 1195                 1200             


Lys Cys  Pro Val Ser Leu Val  Thr Gly Glu Pro His  Ser Leu Ile 
    1205                 1210                 1215             


Cys Thr  Ser Tyr His Pro Asp  Leu Pro Asn His Arg  Pro Leu Thr 
    1220                 1225                 1230             


Gly Trp  Phe Pro Cys Val Ala  Ser Glu Asn Glu Thr  Gln Asp Asp 
    1235                 1240                 1245             


Arg Ser  Glu Gln Pro Glu Gly  Ser Leu Lys Lys Glu  Asp Glu Val 
    1250                 1255                 1260             


Trp Leu  Lys Val Cys Phe Asn  Arg Pro Gly Glu Ala  Arg Ala Ile 
    1265                 1270                 1275             


Phe Ile  Phe Leu Thr Thr Asp  Gly Leu Val Pro Gly  Glu His Gln 
    1280                 1285                 1290             


Gln Pro  Thr Val Thr Leu Tyr  Leu Thr Asp Val Arg  Gly Ser Asn 
    1295                 1300                 1305             


His Ser  Leu Gly Thr Tyr Gly  Leu Ser Cys Gln His  Asn Pro Leu 
    1310                 1315                 1320             


Ile Ile  Asn Val Thr His His  Gln Asn Val Leu Phe  His His Thr 
    1325                 1330                 1335             


Thr Ser  Val Leu Leu Asn Phe  Ser Ser Pro Arg Val  Gly Ile Ser 
    1340                 1345                 1350             


Ala Val  Ala Leu Arg Thr Ser  Ser Arg Ile Gly Leu  Ser Ala Pro 
    1355                 1360                 1365             


Ser Asn  Cys Ile Ser Glu Asp  Glu Gly Gln Asn His  Gln Gly Gln 
    1370                 1375                 1380             


Ser Cys  Ile His Arg Pro Cys  Gly Lys Gln Asp Ser  Cys Pro Ser 
    1385                 1390                 1395             


Leu Leu  Leu Asp His Ala Asp  Val Val Asn Cys Thr  Ser Ile Gly 
    1400                 1405                 1410             


Pro Gly  Leu Met Lys Cys Ala  Ile Thr Cys Gln Arg  Gly Phe Ala 
    1415                 1420                 1425             


Leu Gln  Ala Ser Ser Gly Gln  Tyr Ile Arg Pro Met  Gln Lys Glu 
    1430                 1435                 1440             


Ile Leu  Leu Thr Cys Ser Ser  Gly His Trp Asp Gln  Asn Val Ser 
    1445                 1450                 1455             


Cys Leu  Pro Val Asp Cys Gly  Val Pro Asp Pro Ser  Leu Val Asn 
    1460                 1465                 1470             


Tyr Ala  Asn Phe Ser Cys Ser  Glu Gly Thr Lys Phe  Leu Lys Arg 
    1475                 1480                 1485             


Cys Ser  Ile Ser Cys Val Pro  Pro Ala Lys Leu Gln  Gly Leu Ser 
    1490                 1495                 1500             


Pro Trp  Leu Thr Cys Leu Glu  Asp Gly Leu Trp Ser  Leu Pro Glu 
    1505                 1510                 1515             


Val Tyr  Cys Lys Leu Glu Cys  Asp Ala Pro Pro Ile  Ile Leu Asn 
    1520                 1525                 1530             


Ala Asn  Leu Leu Leu Pro His  Cys Leu Gln Asp Asn  His Asp Val 
    1535                 1540                 1545             


Gly Thr  Ile Cys Lys Tyr Glu  Cys Lys Pro Gly Tyr  Tyr Val Ala 
    1550                 1555                 1560             


Glu Ser  Ala Glu Gly Lys Val  Arg Asn Lys Leu Leu  Lys Ile Gln 
    1565                 1570                 1575             


Cys Leu  Glu Gly Gly Ile Trp  Glu Gln Gly Ser Cys  Ile Pro Val 
    1580                 1585                 1590             


Val Cys  Glu Pro Pro Pro Pro  Val Phe Glu Gly Met  Tyr Glu Cys 
    1595                 1600                 1605             


Thr Asn  Gly Phe Ser Leu Asp  Ser Gln Cys Val Leu  Asn Cys Asn 
    1610                 1615                 1620             


Gln Glu  Arg Glu Lys Leu Pro  Ile Leu Cys Thr Lys  Glu Gly Leu 
    1625                 1630                 1635             


Trp Thr  Gln Glu Phe Lys Leu  Cys Glu Asn Leu Gln  Gly Glu Cys 
    1640                 1645                 1650             


Pro Pro  Pro Pro Ser Glu Leu  Asn Ser Val Glu Tyr  Lys Cys Glu 
    1655                 1660                 1665             


Gln Gly  Tyr Gly Ile Gly Ala  Val Cys Ser Pro Leu  Cys Val Ile 
    1670                 1675                 1680             


Pro Pro  Ser Asp Pro Val Met  Leu Pro Glu Asn Ile  Thr Ala Asp 
    1685                 1690                 1695             


Thr Leu  Glu His Trp Met Glu  Pro Val Lys Val Gln  Ser Ile Val 
    1700                 1705                 1710             


Cys Thr  Gly Arg Arg Gln Trp  His Pro Asp Pro Val  Leu Val His 
    1715                 1720                 1725             


Cys Ile  Gln Ser Cys Glu Pro  Phe Gln Ala Asp Gly  Trp Cys Asp 
    1730                 1735                 1740             


Thr Ile  Asn Asn Arg Ala Tyr  Cys His Tyr Asp Gly  Gly Asp Cys 
    1745                 1750                 1755             


Cys Ser  Ser Thr Leu Ser Ser  Lys Lys Val Ile Pro  Phe Ala Ala 
    1760                 1765                 1770             


Asp Cys  Asp Leu Asp Glu Cys  Thr Cys Arg Asp Pro  Lys Ala Glu 
    1775                 1780                 1785             


Glu Asn  Gln 
    1790     


<210> 2
<211> 827
<212> PRT
<213> Homo sapiens

<400> 2
Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Gly Ile Thr Thr Val Leu 
                805                 810                 815     


Phe Cys Phe Leu Leu Arg Ile His Gly Gly Leu 
            820                 825         


<210> 3
<211> 6940
<212> DNA
<213> Homo sapiens

<400> 3
gggcatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg       60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac      120

aacagtgtca agagcctgga cgccagccag gattgaggtc ctacgggtgt ttggggacct      180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa      240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg      300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca      360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga      420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg      480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta      540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt      600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga      660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt      720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta      780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc      840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag      900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc      960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct     1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct     1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt     1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg     1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa     1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg     1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc     1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca     1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact     1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat     1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga     1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact     1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg     1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac     1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa     1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag     1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg     1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg     2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc     2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga     2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc     2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat     2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct     2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc     2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc     2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtggggagga ggaagcgact     2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat     2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg     2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag     2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc     2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag     2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgagcgt ccaccaggtc     2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gtgagcccag caagattggc     2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc     3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt     3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg     3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg     3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg     3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg     3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc     3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa     3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc     3480

gacaccgccc ccactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc     3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacggatgat     3600

aactgcactg acaacttcac tcctaaccaa gtggcccgaa tgcattgcta tttggaccta     3660

gtctatcagc agtggactga aagcagaaag cccaccccca tccccattcc acctatggtc     3720

atcggacaga ccaacaagtc cctcactatc cactggctgc ctcctattag tggagttgta     3780

tatgacaggg cctcaggcag cttgtgtggc gcttgcactg aagatgggac ctttcgtcag     3840

tatgtgcaca cagcttcctc ccggcgggtg tgtgactcct caggttattg gaccccagag     3900

gaggctgtgg ggcctcctga tgtggatcag ccctgcgagc caagcttaca ggcctggagc     3960

cctgaggtcc acctgtacca catgaacatg acggtcccct gccccacaga aggctgtagc     4020

ttggagctgc tcttccaaca cccggtccaa gccgacaccc tcaccctgtg ggtcacttcc     4080

ttcttcatgg agtcctcgca ggtcctcttt gacacagaga tcttgctgga aaacaaggag     4140

tcagtgcacc tgggcccctt agacactttc tgtgacatcc cactcaccat caaactgcac     4200

gtggatggga aggtgtcggg ggtgaaagtc tacacctttg atgagaggat agagattgat     4260

gcagcactcc tgacttctca gccccacagt cccttgtgct ctggctgcag gcctgtgagg     4320

taccaggttc tccgcgatcc cccatttgcc agtggtttgc ccgtggtggt gacacattct     4380

cacaggaagt tcacggacgt ggaggtcaca cctggacaga tgtatcagta ccaagttcta     4440

gctgaagctg gaggagaact gggagaagct tcgcctcctc tgaaccacat tcatggagct     4500

ccttattgtg gagatgggaa ggtgtcagag agactgggag aagagtgtga tgatggagac     4560

cttgtgagcg gagatggctg ctccaaggtg tgtgagctgg aggaaggttt caactgtgta     4620

ggagagccaa gcctttgcta catgtatgag ggagatggca tatgtgaacc ttttgagaga     4680

aaaaccagca ttgtagactg tggcatctac actcccaaag gatacttgga tcaatgggct     4740

acccgggctt actcctctca tgaagacaag aagaagtgtc ctgtttcctt ggtaactgga     4800

gaacctcatt ccctaatttg cacatcatac catccagatt tacccaacca ccgtccccta     4860

actggctggt ttccctgtgt tgccagtgaa aatgaaactc aggatgacag gagtgaacag     4920

ccagaaggta gcctgaagaa agaggatgag gtttggctca aagtgtgttt caatagacca     4980

ggagaggcca gagcaatttt tatttttttg acaactgatg gcctagttcc cggagagcat     5040

cagcagccga cagtgactct ctacctgacc gatgtccgtg gaagcaacca ctctcttgga     5100

acctatggac tgtcatgcca gcataatcca ctgattatca atgtgaccca tcaccagaat     5160

gtccttttcc accataccac ctcagtgctg ctgaatttct catccccacg ggtcggcatc     5220

tcagctgtgg ctctaaggac atcctcccgc attggtcttt cggctcccag taactgcatc     5280

tcagaggacg aggggcagaa tcatcaggga cagagctgta tccatcggcc ctgtgggaag     5340

caggacagct gtccgtcatt gctgcttgat catgctgatg tggtgaactg tacctctata     5400

ggcccaggtc tcatgaagtg tgctatcact tgtcaaaggg gatttgccct tcaggccagc     5460

agtgggcagt acatcaggcc catgcagaag gaaattctgc tcacatgttc ttctgggcac     5520

tgggaccaga atgtgagctg ccttcccgtg gactgcggtg ttcccgaccc gtctttggtg     5580

aactatgcaa acttctcctg ctcagaggga accaaatttc tgaaacgctg ctcaatctct     5640

tgtgtcccac cagccaagct gcaaggactg agcccatggc tgacatgtct tgaagatggt     5700

ctctggtctc tccctgaagt ctactgcaag ttggagtgtg atgctccccc tattattctg     5760

aatgccaact tgctcctgcc tcactgcctc caggacaacc acgacgtggg caccatctgc     5820

aaatatgaat gcaaaccagg gtactatgtg gcagaaagtg cagagggtaa agtcaggaac     5880

aagctcctga agatacaatg cctggaaggt ggaatctggg agcaaggcag ctgcattcct     5940

gtggtgtgtg agccaccccc tcctgtgttt gaaggcatgt atgaatgtac caatggcttc     6000

agcctggaca gccagtgtgt gctcaactgt aaccaggaac gtgaaaagct tcccatcctc     6060

tgcactaaag agggcctgtg gacccaggag tttaagttgt gtgagaatct gcaaggagaa     6120

tgcccaccac ccccctcaga gctgaattct gtggagtaca aatgtgaaca aggatatggg     6180

attggtgcag tgtgttcccc attgtgtgta atccccccca gtgaccccgt gatgctacct     6240

gagaatatca ctgctgacac tctggagcac tggatggaac ctgtcaaagt ccagagcatt     6300

gtgtgcactg gccggcgtca atggcaccca gaccccgtct tagtccactg catccagtca     6360

tgtgagccct tccaagcaga tggttggtgt gacactatca acaaccgagc ctactgccac     6420

tatgacgggg gagactgctg ctcttccaca ctctcctcca agaaggtcat tccatttgct     6480

gctgactgtg acctggatga gtgcacctgc cgggacccca aggcagaaga aaatcagtaa     6540

ctgtgggaac aagcccctcc ctccactgcc tcagaggcag taagaaagag aggccgaccc     6600

aggaggaaac aaagggtgaa tgaagaagaa caatcatgaa atggaagaag gaggaagagc     6660

atgaaggatc ttataagaaa tgcaagagga tattgatagg tgtgaactag ttcatcaagt     6720

agcccaagta ggagagaatc ataggcaaaa gtttctttaa agtggcagtt gattaacatg     6780

gaaggggaaa tatgatagat atataaggac cctcctccct cacttatatt ctattaaatc     6840

ctatcctcaa ctcttgccct gctctccgct ccaccccctg ccaactactc agtcccaccc     6900

aacttgtaaa ccaataccaa aaaaaaaaaa aaaaaaaaaa                           6940


<210> 4
<211> 4370
<212> DNA
<213> Homo sapiens

<400> 4
gggcatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg       60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac      120

aacagtgtca agagcctgga cgccagccag gattgaggtc ctacgggtgt ttggggacct      180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa      240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg      300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca      360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga      420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg      480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta      540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt      600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga      660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt      720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta      780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc      840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag      900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc      960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct     1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct     1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt     1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg     1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa     1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg     1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc     1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca     1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact     1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat     1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga     1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact     1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg     1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac     1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa     1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag     1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg     1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg     2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc     2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga     2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc     2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat     2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct     2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc     2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc     2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtggggagga ggaagcgact     2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat     2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg     2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag     2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc     2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag     2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgagcgt ccaccaggtc     2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gtgagcccag caagattggc     2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc     3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt     3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg     3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg     3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg     3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg     3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc     3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa     3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc     3480

gacaccgccc ccactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc     3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacgggtatc     3600

accactgtct tgttttgttt tctgttaaga atacatgggg gcctttgaga gctgggaggg     3660

tggaggtgtg ggagctgatg ggagaatgat taagtggtca tttgtgtcgg agagttgaag     3720

tgtatttatt ataaggtatt attatttttt catgtctttg aagaacttga agaaatactg     3780

acatattaag gtactttgtt cactgaattc tcctctacta gatattttaa aatatacttc     3840

tatcctcgat agtaaaaaag gcacagagcc aaaagccctc ttgtgatccc cttgacttct     3900

agaatgtggt tattcttatt tttgcccgca ttcttagaca tttactctga agaagagtcc     3960

aatggaaata aaggaaaaga gtttatgggt caaggtggcc cattgtactg tttttgaagt     4020

tggtcaacaa ggtggcttgg ttaatttagg ctcagcatgt tttactgtat gttactaaaa     4080

aaaaaaaaaa aaaaaatcag attctctttt tccagcacta gtcaagcaca aattcttagc     4140

tgcctaccac cctttcccca ccaaaaggtg acatctaatt ttaaaaaaat ggcatcttcc     4200

tggccctcgg aaaaacttgt catctggtct ttcttgcctt aattcagctt ctgtattatt     4260

cttcgctgtc tctcacgcct tccttgtttc ttgtgaaaag taatagtgac tggtttccta     4320

taatggactc aaagttatcc ctaaaattaa agacttattt gatgacctag                4370


<210> 5
<211> 424
<212> PRT
<213> Homo sapiens

<400> 5
Met Asp Phe Ser Arg Arg Ser Phe His Arg Ser Leu Ser Ser Ser Leu 
1               5                   10                  15      


Gln Ala Pro Val Val Ser Thr Val Gly Met Gln Arg Leu Gly Thr Thr 
            20                  25                  30          


Pro Ser Val Tyr Gly Gly Ala Gly Gly Arg Gly Ile Arg Ile Ser Asn 
        35                  40                  45              


Ser Arg His Thr Val Asn Tyr Gly Ser Asp Leu Thr Gly Gly Gly Asp 
    50                  55                  60                  


Leu Phe Val Gly Asn Glu Lys Met Ala Met Gln Asn Leu Asn Asp Arg 
65                  70                  75                  80  


Leu Ala Ser Tyr Leu Glu Lys Val Arg Thr Leu Glu Gln Ser Asn Ser 
                85                  90                  95      


Lys Leu Glu Val Gln Ile Lys Gln Trp Tyr Glu Thr Asn Ala Pro Arg 
            100                 105                 110         


Ala Gly Arg Asp Tyr Ser Ala Tyr Tyr Arg Gln Ile Glu Glu Leu Arg 
        115                 120                 125             


Ser Gln Ile Lys Asp Ala Gln Leu Gln Asn Ala Arg Cys Val Leu Gln 
    130                 135                 140                 


Ile Asp Asn Ala Lys Leu Ala Ala Glu Asp Phe Arg Leu Lys Tyr Glu 
145                 150                 155                 160 


Thr Glu Arg Gly Ile Arg Leu Thr Val Glu Ala Asp Leu Gln Gly Leu 
                165                 170                 175     


Asn Lys Val Phe Asp Asp Leu Thr Leu His Lys Thr Asp Leu Glu Ile 
            180                 185                 190         


Gln Ile Glu Glu Leu Asn Lys Asp Leu Ala Leu Leu Lys Lys Glu His 
        195                 200                 205             


Gln Glu Glu Val Asp Gly Leu His Lys His Leu Gly Asn Thr Val Asn 
    210                 215                 220                 


Val Glu Val Asp Ala Ala Pro Gly Leu Asn Leu Gly Val Ile Met Asn 
225                 230                 235                 240 


Glu Met Arg Gln Lys Tyr Glu Val Met Ala Gln Lys Asn Leu Gln Glu 
                245                 250                 255     


Ala Lys Glu Gln Phe Glu Arg Gln Thr Ala Val Leu Gln Gln Gln Val 
            260                 265                 270         


Thr Val Asn Thr Glu Glu Leu Lys Gly Thr Glu Val Gln Leu Thr Glu 
        275                 280                 285             


Leu Arg Arg Thr Ser Gln Ser Leu Glu Ile Glu Leu Gln Ser His Leu 
    290                 295                 300                 


Ser Met Lys Glu Ser Leu Glu His Thr Leu Glu Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Tyr Ser Ser Gln Leu Ala Asn Leu Gln Ser Leu Leu Ser Ser Leu Glu 
                325                 330                 335     


Ala Gln Leu Met Gln Ile Arg Ser Asn Met Glu Arg Gln Asn Asn Glu 
            340                 345                 350         


Tyr His Ile Leu Leu Asp Ile Lys Thr Arg Leu Glu Gln Glu Ile Ala 
        355                 360                 365             


Thr Tyr Arg Arg Leu Leu Glu Gly Glu Asp Val Lys Thr Thr Glu Tyr 
    370                 375                 380                 


Gln Leu Ser Thr Leu Glu Glu Arg Asp Ile Lys Lys Thr Arg Lys Ile 
385                 390                 395                 400 


Lys Thr Val Val Gln Glu Val Val Asp Gly Lys Val Val Ser Ser Glu 
                405                 410                 415     


Val Lys Glu Val Glu Glu Asn Ile 
            420                 


<210> 6
<211> 1805
<212> DNA
<213> Homo sapiens

<400> 6
gagacacact ctgccccaac catcctgaag ctacaggtgc tccctcctgg aatctccaat       60

ggatttcagt cgcagaagct tccacagaag cctgagctcc tccttgcagg cccctgtagt      120

cagtacagtg ggcatgcagc gcctcgggac gacacccagc gtttatgggg gtgctggagg      180

ccggggcatc cgcatctcca actccagaca cacggtgaac tatgggagcg atctcacagg      240

cggcggggac ctgtttgttg gcaatgagaa aatggccatg cagaacctaa atgaccgtct      300

agcgagctac ctagaaaagg tgcggaccct ggagcagtcc aactccaaac ttgaagtgca      360

aatcaagcag tggtacgaaa ccaacgcccc gagggctggt cgcgactaca gtgcatatta      420

cagacaaatt gaagagctgc gaagtcagat taaggatgct caactgcaaa atgctcggtg      480

tgtcctgcaa attgataatg ctaaactggc tgctgaggac ttcagactga agtatgagac      540

tgagagagga atacgtctaa cagtggaagc tgatctccaa ggcctgaata aggtctttga      600

tgacctaacc ctacataaaa cagatttgga gattcaaatt gaagaactga ataaagacct      660

agctctcctc aaaaaggagc atcaggagga agtcgatggc ctacacaagc atctgggcaa      720

cactgtcaat gtggaggttg atgctgctcc aggcctgaac cttggcgtca tcatgaatga      780

aatgaggcag aagtatgaag tcatggccca gaagaacctt caagaggcca aagaacagtt      840

tgagagacag actgcagttc tgcagcaaca ggtcacagtg aatactgaag aattaaaagg      900

aactgaggtt caactaacgg agctgagacg cacctcccag agccttgaga tagaactcca      960

gtcccatctc agcatgaaag agtctttgga gcacactcta gaggagacca aggcccgtta     1020

cagcagccag ttagccaacc tccagtcgct gttgagctct ctggaggccc aactgatgca     1080

gattcggagt aacatggaac gccagaacaa cgaataccat atccttcttg acataaagac     1140

tcgacttgaa caggaaattg ctacttaccg ccgccttctg gaaggagaag acgtaaaaac     1200

tacagaatat cagttaagca ccctggaaga gagagatata aagaaaacca ggaagattaa     1260

gacagtcgtg caagaagtag tggatggcaa ggtcgtgtca tctgaagtca aagaggtgga     1320

agaaaatatc taaatagcta ccagaaggag atgctgctga ggttttgaaa gaaatttggc     1380

tataatctta tctttgctcc ctgcaagaaa tcagccataa gaaagcacta ttaatactct     1440

gcagtgatta gaaggggtgg ggtggcggga atcctattta tcagactctg taattgaata     1500

taaatgtttt actcagagga gctgcaaatt gcctgcaaaa atgaaatcca gtgagcacta     1560

gaatatttaa aacatcatta ctgccatctt tatcatgaag cacatcaatt acaagctgta     1620

gaccacctaa tatcaatttg taggtaatgt tcctgaaaat tgcaatacat ttcaattata     1680

ctaaacctca caaagtagag gaatccatgt aaattgcaaa taaaccactt tctaattttt     1740

tcctgtttct gaattgtaaa accccctttg ggagtccctg gtttcttatt gagccaattt     1800

ctggg                                                                 1805


<210> 7
<211> 323
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 
            20                  25                  30          


Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 
        35                  40                  45              


Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 
    50                  55                  60                  


Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  


Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 
                85                  90                  95      


Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 
            100                 105                 110         


Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             


Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 
    130                 135                 140                 


Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 


Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     


Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 
            180                 185                 190         


Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             


Thr Ser Gln Lys Ala Ala Gly Asp Val Asp Ile Gly Asp Ala Ala Tyr 
    210                 215                 220                 


Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 
225                 230                 235                 240 


Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 
                245                 250                 255     


Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 
            260                 265                 270         


Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 
        275                 280                 285             


Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 
    290                 295                 300                 


Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 
305                 310                 315                 320 


Pro Ser Leu 
            


<210> 8
<211> 2080
<212> DNA
<213> Homo sapiens

<400> 8
gcgggtcccc agaagcctac aggtgagtat cggttctccc cttcccggct ttcggtccgg       60

aggaggcggg agcagcttcc ctgttctgat cctatcgcgg gcggcgcagg gccggcttgg      120

ccttccgtgg gacggggagg ggggcgggat gtgtcaccca aataccagtg gggacggtcg      180

gtggtggaac cagccgggca ggtcgggtag agtataagag ccggagggag cggccgggcg      240

gcagacgcct gcagaccatc ccagacgccg gagcccgagc cccgacgagt ccccgcgcct      300

catccgcccg cgtccggtcc gcgttcctcc gccccaccat ggctcggggc cccggcctcg      360

cgccgccacc gctgcggctg ccgctgctgc tgctggtgct ggcggcggtg accggccaca      420

cggccgcgca ggacaactgc acgtgtccca ccaacaagat gaccgtgtgc agccccgacg      480

gccccggcgg ccgctgccag tgccgcgcgc tgggctcggg catggcggtc gactgctcca      540

cgctgacctc caagtgtctg ctgctcaagg cgcgcatgag cgcccccaag aacgcccgca      600

cgctggtgcg gccgagtgag cacgcgctcg tggacaacga tggcctctac gaccccgact      660

gcgaccccga gggccgcttc aaggcgcgcc agtgcaacca gacgtcggtg tgctggtgcg      720

tgaactcggt gggcgtgcgc cgcacggaca agggcgacct gagcctacgc tgcgatgagc      780

tggtgcgcac ccaccacatc ctcattgacc tgcgccaccg ccccaccgcc ggcgccttca      840

accactcaga cctggacgcc gagctgaggc ggctcttccg cgagcgctat cggctgcacc      900

ccaagttcgt ggcggccgtg cactacgagc agcccaccat ccagatcgag ctgcggcaga      960

acacgtctca gaaggccgcc ggtgacgtgg atatcggcga tgccgcctac tacttcgaga     1020

gggacatcaa gggcgagtct ctattccagg gccgcggcgg cctggacttg cgcgtgcgcg     1080

gagaacccct gcaggtggag cgcacgctca tctattacct ggacgagatt cccccgaagt     1140

tctccatgaa gcgcctcacc gccggcctca tcgccgtcat cgtggtggtc gtggtggccc     1200

tcgtcgccgg catggccgtc ctggtgatca ccaaccggag aaagtcgggg aagtacaaga     1260

aggtggagat caaggaactg ggggagttga gaaaggaacc gagcttgtag gtacccggcg     1320

gggcagggga tggggtgggg taccggattt cggtatcgtc ccagacccaa gtgagtcacg     1380

cttcctgatt cctcggcgca aaggagacgt ttatcctttc aaattcctgc cttccccctc     1440

ccttttgcgc acacaccagg tttaatagat cctggcctca gggtctcctt tctttctcac     1500

ttctgtcttg aaggaagcat ttctaaaatg tatccccttt cggtccaaca acaggaaacc     1560

tgactggggc agtgaaggaa gggatggcat agcgttatgt gtaaaaaaca agtatctgta     1620

tgacaacccg ggatcgtttg caagtaactg aatccattgc gacattgtga aggcttaaat     1680

gagtttagat gggaaatagc gttgttatcg ccttgggttt aaattatttg atgagttcca     1740

cttgtatcat ggcctacccg aggagaagag gagtttgtta actgggccta tgtagtagcc     1800

tcatttacca tcgtttgtat tactgaccac atatgcttgt cactgggaaa gaagcctgtt     1860

tcagctgcct gaacgcagtt tggatgtctt tgaggacaga cattgcccgg aaactcagtc     1920

tatttattct tcagcttgcc cttactgcca ctgatattgg taatgttctt ttttgtaaaa     1980

tgtttgtaca tatgttgtct ttgataatgt tgctgtaatt ttttaaaata aaacacgaat     2040

ttaataaaat atgggaaagg cacaaaccag aaaaaaaaaa                           2080


<210> 9
<211> 198
<212> PRT
<213> Homo sapiens

<400> 9
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210> 10
<211> 863
<212> DNA
<213> Homo sapiens

<400> 10
agggccaccc aggtgagcct ctcactcgcc acctcctctt ccacccctgc caggcccagc       60

agccaccaca gcgcctgctt cctcggccct gaaatcatgc ccctaggtct cctgtggctg      120

ggcctagccc tgttgggggc tctgcatgcc caggcccagg actccacctc agacctgatc      180

ccagccccac ctctgagcaa ggtccctctg cagcagaact tccaggacaa ccaattccag      240

gggaagtggt atgtggtagg cctggcaggg aatgcaattc tcagagaaga caaagacccg      300

caaaagatgt atgccaccat ctatgagctg aaagaagaca agagctacaa tgtcacctcc      360

gtcctgttta ggaaaaagaa gtgtgactac tggatcagga cttttgttcc aggttgccag      420

cccggcgagt tcacgctggg caacattaag agttaccctg gattaacgag ttacctcgtc      480

cgagtggtga gcaccaacta caaccagcat gctatggtgt tcttcaagaa agtttctcaa      540

aacagggagt acttcaagat caccctctac gggagaacca aggagctgac ttcggaacta      600

aaggagaact tcatccgctt ctccaaatct ctgggcctcc ctgaaaacca catcgtcttc      660

cctgtcccaa tcgaccagtg tatcgacggc tgagtgcaca ggtgccgcca gctgccgcac      720

cagcccgaac accattgagg gagctgggag accctcccca cagtgccacc catgcagctg      780

ctccccaggc caccccgctg atggagcccc accttgtctg ctaaataaac atgtgccctc      840

aggccaaaaa aaaaaaaaaa aaa                                              863


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
gatcagagcc aaagcagtga g                                                 21


<210> 12
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
ggattaccta atacgactca ctatagggtt ctctgtgacc cagtccatc                   49


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
ctctcctctt cctcctcttc g                                                 21


<210> 14
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
ggattaccta atacgactca ctatagggtg acctcacagc tcaagaaca                   49


<210> 15
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
aaaaacagaa ggcagcttta cg                                                22


<210> 16
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
ggattaccta atacgactca ctatagggaa agatggagtg gcagacaga                   49


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
cagagggagg acagagcaa                                                    19


<210> 18
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ggccagtgaa ttgtaatacg actcactata gggaggcggg taaaggtgac agaatctcag       60

g                                                                       61


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tgctccaaaa ctcagcagtg                                                   20


<210> 20
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ggccagtgaa ttgtaatacg actcactata gggaggcggc gcctcctatt gaagtcagc        59


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gcaatgggct cacaggtatt                                                   20


<210> 22
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
ggccagtgaa ttgtaatacg actcactata gggaggcggt ttgtatttgc ccgacttcc        59


