                               SEQUENCE LISTING

<110> NOVARTIS AG
      THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120> TREATMENT OF CANCER USING CHIMERIC CD3 RECEPTOR PROTEINS

<130> PAT057024-WO-PCT

<140>
<141>

<150> 62/202,446
<151> 2015-08-07

<160> 62    

<170> PatentIn version 3.5

<210> 1
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
145                 150                 155                 160 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 
                165                 170                 175     


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr 
        195                 200                 205             


Thr Tyr Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp 
    210                 215                 220                 


Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
                245                 250                 255     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210> 2
<211> 476
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Met Phe Asn Ala 
    370                 375                 380                 


Lys Tyr Val Ala Glu Ala Thr Gly Asn Phe Ile Thr Val Met Asp Ala 
385                 390                 395                 400 


Leu Lys Leu Asn Tyr Asn Ala Lys Asp Gln Leu His Pro Leu Leu Ala 
                405                 410                 415     


Glu Leu Leu Ile Ser Ile Asn Arg Val Thr Arg Asp Asp Phe Glu Asn 
            420                 425                 430         


Arg Ser Lys Leu Ile Asp Trp Ile Val Arg Ile Asn Lys Leu Ser Ile 
        435                 440                 445             


Gly Asp Thr Leu Thr Glu Thr Gln Ile Arg Glu Leu Leu Phe Asp Leu 
    450                 455                 460                 


Glu Leu Ala Tyr Lys Ser Phe Tyr Ala Leu Leu Asp 
465                 470                 475     


<210> 3
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Gly Ser Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu 
1               5                   10                  15      


Leu Ser Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly 
            20                  25                  30          


Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile 
        35                  40                  45              


Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn 
    50                  55                  60                  


Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp 
65                  70                  75                  80  


Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly 
                85                  90                  95      


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe 
            100                 105                 110         


Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125             


Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
    130                 135                 140                 


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
145                 150                 155                 160 


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
                165                 170                 175     


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro 
            180                 185                 190         


Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg 
        195                 200                 205             


Ile Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Ser Gly Ala Ser Ala Asp Val Val Ser Thr Trp Val Cys Pro 
225                 230                 235                 240 


Ile Cys Met Val Ser Asn Glu Thr Gln Gly Glu Phe Thr Lys Asp Thr 
                245                 250                 255     


Leu Pro Thr Pro Ile Cys Ile Asn Cys Gly Val Pro Ala Asp Tyr Glu 
            260                 265                 270         


Leu Thr Lys Ser Ser Ile Asn Cys Ser Asn Ala Ile Asp Pro Asn Ala 
        275                 280                 285             


Asn Pro Arg Asn Gln Phe Gly 
    290                 295 


<210> 4
<211> 417
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Ile Ala Arg 
    370                 375                 380                 


Leu Glu Glu Glu Val Lys Thr Leu Glu Ala Gln Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Ser Thr Ala Asn Met Leu Glu Glu Gln Val Ala Gln Leu Lys Gln Lys 
                405                 410                 415     


Val 
    


<210> 5
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Gly Ser Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu 
1               5                   10                  15      


Leu Ser Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly 
            20                  25                  30          


Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile 
        35                  40                  45              


Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn 
    50                  55                  60                  


Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp 
65                  70                  75                  80  


Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly 
                85                  90                  95      


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe 
            100                 105                 110         


Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125             


Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
    130                 135                 140                 


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
145                 150                 155                 160 


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
                165                 170                 175     


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro 
            180                 185                 190         


Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg 
        195                 200                 205             


Ile Gly Ser Gly Ser Gly Gly Ser Leu Thr Asp Thr Leu Gln Ala Lys 
    210                 215                 220                 


Thr Asp Gln Leu Lys Asp Glu Lys Ser Ala Leu Gln Thr Lys Ile Ala 
225                 230                 235                 240 


Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu 
                245                 250             


<210> 6
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Gly Ser Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu 
1               5                   10                  15      


Leu Ser Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly 
            20                  25                  30          


Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile 
        35                  40                  45              


Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn 
    50                  55                  60                  


Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp 
65                  70                  75                  80  


Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly 
                85                  90                  95      


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe 
            100                 105                 110         


Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125             


Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
    130                 135                 140                 


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Arg Ser Lys Arg Ser Arg 
145                 150                 155                 160 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                165                 170                 175     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            180                 185                 190         


Tyr Arg Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Gly Ser 
        195                 200                 205             


Gly Ser Gly Ser Ser Gly Ala Ser Ala Asp Val Val Ser Thr Trp Val 
    210                 215                 220                 


Cys Pro Ile Cys Met Val Ser Asn Glu Thr Gln Gly Glu Phe Thr Lys 
225                 230                 235                 240 


Asp Thr Leu Pro Thr Pro Ile Cys Ile Asn Cys Gly Val Pro Ala Asp 
                245                 250                 255     


Tyr Glu Leu Thr Lys Ser Ser Ile Asn Cys Ser Asn Ala Ile Asp Pro 
            260                 265                 270         


Asn Ala Asn Pro Arg Asn Gln Phe Gly 
        275                 280     


<210> 7
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
        275                 280                 285             


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
    290                 295                 300                 


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
305                 310                 315                 320 


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
                325                 330                 335     


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
            340                 345                 350         


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
        355                 360                 365             


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
    370                 375                 380                 


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
385                 390                 395                 400 


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala 
                405                 410                 415     


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
            420                 425                 430         


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
        435                 440                 445             


Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
    450                 455         


<210> 8
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
        275                 280                 285             


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
    290                 295                 300                 


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
305                 310                 315                 320 


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
                325                 330                 335     


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
            340                 345                 350         


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
        355                 360                 365             


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
    370                 375                 380                 


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
385                 390                 395                 400 


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala 
                405                 410                 415     


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
            420                 425                 430         


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
        435                 440                 445             


Tyr Ser Gly Leu Asn Gln Arg Arg Ile Gly Ser Gly Ser Gly Gly Ser 
    450                 455                 460                 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
465                 470                 475                 480 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                485                 490                 495     


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505     


<210> 9
<211> 444
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
        275                 280                 285             


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
    290                 295                 300                 


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
305                 310                 315                 320 


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
                325                 330                 335     


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
            340                 345                 350         


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
        355                 360                 365             


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
    370                 375                 380                 


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
385                 390                 395                 400 


Trp Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                405                 410                 415     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            420                 425                 430         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        435                 440                 


<210> 10
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser 
    210                 215                 220                 


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg 
    450     


<210> 11
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser 
    210                 215                 220                 


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Phe 
            340                 345                 350         


Lys Gln Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg 
    450     


<210> 12
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser 
    210                 215                 220                 


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380     


<210> 13
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
                405                 410                 415     


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            420                 425                 430         


Asn Pro Asp Phe Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Phe Ser 
        435                 440                 445             


Gly Leu Asn Gln Arg Arg Ile 
    450                 455 


<210> 14
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Met Gly Val Gln 
    370                 375                 380                 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
385                 390                 395                 400 


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
                405                 410                 415     


Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
            420                 425                 430         


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
        435                 440                 445             


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
    450                 455                 460                 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
465                 470                 475                 480 


Asp Val Glu Leu Leu Lys Leu Glu 
                485             


<210> 15
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Gly Ser Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu 
1               5                   10                  15      


Leu Ser Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly 
            20                  25                  30          


Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile 
        35                  40                  45              


Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn 
    50                  55                  60                  


Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp 
65                  70                  75                  80  


Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly 
                85                  90                  95      


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe 
            100                 105                 110         


Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125             


Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
    130                 135                 140                 


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
145                 150                 155                 160 


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
                165                 170                 175     


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro 
            180                 185                 190         


Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg 
        195                 200                 205             


Ile Gly Ser Gly Ser Gly Gly Ser Ile Leu Trp His Glu Met Trp His 
    210                 215                 220                 


Glu Gly Leu Ile Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
225                 230                 235                 240 


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
                245                 250                 255     


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
            260                 265                 270         


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
        275                 280                 285             


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
    290                 295                 300                 


Arg Arg Ile Ser Lys 
305                 


<210> 16
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Gly Ser Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu 
1               5                   10                  15      


Leu Ser Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly 
            20                  25                  30          


Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile 
        35                  40                  45              


Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn 
    50                  55                  60                  


Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp 
65                  70                  75                  80  


Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly 
                85                  90                  95      


Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe 
            100                 105                 110         


Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125             


Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
    130                 135                 140                 


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys 
145                 150                 155                 160 


Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly 
                165                 170                 175     


Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Phe Glu Pro 
            180                 185                 190         


Ile Arg Lys Gly Gln Arg Asp Leu Phe Ser Gly Leu Asn Gln Arg Arg 
        195                 200                 205             


Ile Gly Ser Gly Ser Gly Gly Ser Ile Leu Trp His Glu Met Trp His 
    210                 215                 220                 


Glu Gly Leu Ile Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
225                 230                 235                 240 


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
                245                 250                 255     


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
            260                 265                 270         


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
        275                 280                 285             


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
    290                 295                 300                 


Arg Arg Ile Ser Lys 
305                 


<210> 17
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        275                 280                 285             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    290                 295                 300                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360         


<210> 18
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Ser Glu 
        275                 280                 285             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    290                 295                 300                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360         


<210> 19
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        275                 280                 285             


Asn Ser Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    290                 295                 300                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360         


<210> 20
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Ser Glu 
        275                 280                 285             


Asn Ser Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    290                 295                 300                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360         


<210> 21
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
                405                 410                 415     


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            420                 425                 430         


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        435                 440                 445             


<210> 22
<211> 441
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                405                 410                 415     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            420                 425                 430         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        435                 440     


<210> 23
<211> 437
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                405                 410                 415     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            420                 425                 430         


Thr Leu Ala Lys Ile 
        435         


<210> 24
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                405                 410                 415     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            420                 425                 430         


Val Thr Leu 
        435 


<210> 25
<211> 516
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Gly 
            260                 265                 270         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        275                 280                 285             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    290                 295                 300                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                325                 330                 335     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            340                 345                 350         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        355                 360                 365             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    370                 375                 380                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
385                 390                 395                 400 


Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
                405                 410                 415     


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            420                 425                 430         


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        435                 440                 445             


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    450                 455                 460                 


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
465                 470                 475                 480 


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                485                 490                 495     


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            500                 505                 510         


Pro Ser Ser Asn 
        515     


<210> 26
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro 
        275                 280                 285             


Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln 
    290                 295                 300                 


Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly 
305                 310                 315                 320 


Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser 
                325                 330                 335     


Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr 
            340                 345                 350         


Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg 
        355                 360                 365             


Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala 
    370                 375                 380                 


Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu 
385                 390                 395                 400 


Val Tyr Tyr Trp Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
                405                 410                 415     


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            420                 425                 430         


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        435                 440                 445         


<210> 27
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly Asn 
        275                 280                 285             


Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser 
    290                 295                 300                 


Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile 
305                 310                 315                 320 


Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys 
                325                 330                 335     


Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu 
            340                 345                 350         


Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro 
        355                 360                 365             


Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn 
    370                 375                 380                 


Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp 
385                 390                 395                 400 


Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
                405                 410                 415     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            420                 425                 430         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        435                 440                 445             


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    450                 455         


<210> 28
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
        275                 280                 285             


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
    290                 295                 300                 


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
305                 310                 315                 320 


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
                325                 330                 335     


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
            340                 345                 350         


Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu 
        355                 360                 365             


Leu Ala Leu Gly Val Phe Cys Phe Ala Lys Arg Gly Arg Lys Lys Leu 
    370                 375                 380                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
385                 390                 395                 400 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                405                 410                 415     


Cys Glu Leu 
            


<210> 29
<211> 422
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe 
        275                 280                 285             


Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr 
    290                 295                 300                 


Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp 
305                 310                 315                 320 


Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys 
                325                 330                 335     


Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu 
            340                 345                 350         


Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala 
        355                 360                 365             


Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu 
            420         


<210> 30
<211> 432
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Lys Ile 
        275                 280                 285             


Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn Thr Ser 
    290                 295                 300                 


Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp Ile Thr 
305                 310                 315                 320 


Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg 
                325                 330                 335     


Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val Gln Val 
            340                 345                 350         


His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala Thr Val 
        355                 360                 365             


Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu 
    370                 375                 380                 


Gly Val Phe Cys Phe Ala Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
385                 390                 395                 400 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                405                 410                 415     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425                 430         


<210> 31
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Gly Ser Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser 
        195                 200                 205             


Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
    210                 215                 220                 


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        275                 280                 285             


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    290                 295                 300                 


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
305                 310                 315                 320 


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                325                 330                 335     


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            340                 345                 350         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        355                 360                 365             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    370                 375                 380                 


Phe Ile Ala Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
385                 390                 395                 400 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                405                 410                 415     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425                 


<210> 32
<211> 432
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp 
        275                 280                 285             


Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys 
    290                 295                 300                 


Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu 
305                 310                 315                 320 


Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly 
                325                 330                 335     


Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val 
            340                 345                 350         


Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile 
        355                 360                 365             


Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val 
    370                 375                 380                 


Gly Val Tyr Phe Ile Ala Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
385                 390                 395                 400 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                405                 410                 415     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425                 430         


<210> 33
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ile 
        275                 280                 285             


Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu Asp Gly Ser 
    290                 295                 300                 


Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr Trp Phe Lys 
305                 310                 315                 320 


Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys Lys Trp Asn 
                325                 330                 335     


Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly 
            340                 345                 350         


Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg Met Cys Gln 
        355                 360                 365             


Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe Leu Phe Ala 
    370                 375                 380                 


Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        435                 440         


<210> 34
<211> 342
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu 
        195                 200                 205             


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
    210                 215                 220                 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser 
            260                 265                 270         


Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu 
        275                 280                 285             


Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Lys Arg Gly Arg 
    290                 295                 300                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
305                 310                 315                 320 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                325                 330                 335     


Glu Gly Gly Cys Glu Leu 
            340         


<210> 35
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 
65                  70                  75                  80  


Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr 
        195                 200                 205             


Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly 
                245                 250                 255     


Pro Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210> 36
<211> 441
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 
65                  70                  75                  80  


Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr 
        195                 200                 205             


Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly 
                245                 250                 255     


Pro Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Asp Gly Asn 
            260                 265                 270         


Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser 
        275                 280                 285             


Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile 
    290                 295                 300                 


Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys 
305                 310                 315                 320 


Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu 
                325                 330                 335     


Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro 
            340                 345                 350         


Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn 
        355                 360                 365             


Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp 
    370                 375                 380                 


Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
385                 390                 395                 400 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                405                 410                 415     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            420                 425                 430         


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        435                 440     


<210> 37
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 
65                  70                  75                  80  


Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr 
        195                 200                 205             


Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly 
                245                 250                 255     


Pro Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Thr Gly Gly Gly Ser Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
305                 310                 315                 320 


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
                325                 330                 335     


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
            340                 345                 350         


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
        355                 360                 365             


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
    370                 375                 380                 


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
385                 390                 395                 400 


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
                405                 410                 415     


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
            420                 425                 430         


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Arg Gly Arg Lys Lys Leu Leu 
        435                 440                 445             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    450                 455                 460                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
465                 470                 475                 480 


Glu Leu 
        


<210> 38
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly 
65                  70                  75                  80  


Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr 
        195                 200                 205             


Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly 
                245                 250                 255     


Pro Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Asp Gly Asn 
            260                 265                 270         


Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser 
        275                 280                 285             


Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile 
    290                 295                 300                 


Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys 
305                 310                 315                 320 


Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu 
                325                 330                 335     


Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro 
            340                 345                 350         


Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn 
        355                 360                 365             


Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp 
    370                 375                 380                 


Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Gln 
385                 390                 395                 400 


Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala 
                405                 410                 415     


Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile 
            420                 425                 430         


Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        435                 440                 445         


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Arg Gly Asp Ser 
1               


<210> 40
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> VARIANT
<222> (1)..(3)
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(21)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations for 
      variant positions"

<400> 40
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 41
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> VARIANT
<222> (1)..(3)
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(22)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations for 
      variant positions"

<400> 41
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 42
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> VARIANT
<222> (1)..(3)
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(23)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations for 
      variant positions"

<400> 42
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 43
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> VARIANT
<222> (1)..(3)
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(25)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations for 
      variant positions"

<400> 43
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 44
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gly Gly Gly Ser 
1               


<210> 45
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 47
<211> 1184
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 47
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210> 48
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 49
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

ccc                                                                     63


<210> 50
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 51
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 51
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gly Gly Gly Gly Ser 
1               5   


<210> 53
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Asp Val Pro Asp Tyr Ala Ser Leu Gly Gly Pro Ser Ser Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Thr Ser Tyr 
    130         


<210> 54
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
1               5                   10                  15      


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
            20                  25                  30          


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
        35                  40                  45              


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    50                  55                  60                  


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
65                  70                  75                  80  


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                85                  90                  95      


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Ser 
            100                 105             


<210> 55
<211> 93
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90              


<210> 56
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Ile Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 57
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Leu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 58
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 59
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Any amino acid

<400> 59
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Xaa Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Xaa Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 60
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Ile Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 61
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Ile Leu Trp His Glu Met Trp His Glu Gly Leu Leu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Ser 
                85                  90                  95  


<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


