                         SEQUENCE LISTING

<110>  Alexion Pharmaceuticals, Inc.
 
<120>  PRODUCTION OF ADAMTS13 USING mRNA

<130>  0357

<150>  62/202,604
<151>  2015-08-07

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  FLAG Tag sequence

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  6x His Tag

<400>  2

His His His His His His 
1               5       


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Hemagglutinin Tag

<400>  3

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  4
<211>  1427
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  5
<211>  4290
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagttg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caagggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctgcgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctaatagtga                                      4290


<210>  6
<211>  4314
<212>  DNA
<213>  Artificial

<220>
<223>  FLAG-Tagged ADAMTS13 coding sequence

<400>  6
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagttg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caagggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctgcgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac cgactacaaa gacgatgacg acaagtaata gtga           4314


