                        SEQUENCE LISTING

<110>  Arrowhead Pharmaceuticals, Inc.
       Wooddell, Christine, I
       Rozema, David B.
       Lewis, David L
       Wakefield, Darren H
       Almeida, Lauren J
 
<120>  RNAi Therapy for Hepatitis B Virus Infection

<130>  30635_WO1

<150>  62370754
<151>  2016-08-04

<150>  62202253
<151>  2015-08-07

<160>  766

<210>  1
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  1
taccaauuua ugccuacagt t                     21


<210>  2
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  2
taugauaaaa cgccgcagat t                     21


<210>  3
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  3
tagaugauua ggcagaggut t                     21


<210>  4
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  4
tacaaauggc acuaguaaat t                     21


<210>  5
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  5
taccaauuua ugccuacagg ccuuau                26


<210>  6
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  6
taugauaaaa cgccgcagac acauau                26


<210>  7
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  7
tagaugauua ggcagagguu gaauau                26


<210>  8
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  8
ugauaaaacg ccgcagacac aucuau                26


<210>  9
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  9
ugaacaaaug gcacuaguaa acuuau                26


<210>  10
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  10
ugcgucagca aacacuuggc acauau                26


<210>  11
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  11
ugaaccacug aacaaauggc acuuau                26


<210>  12
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  12
uaacgggcaa cauaccuuga uaauau                26


<210>  13
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  13
uacuaguaaa cugagccagg agauau                26


<210>  14
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  14
uggacaaacg ggcaacauac cuuuau                26


<210>  15
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  15
uacgggcaac auaccuugau aauuau                26


<210>  16
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  16
ugaagcgaag ugcacacgga ccguau                26


<210>  17
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  17
uaccaauuua ugccuacagg ccuuau                26


<210>  18
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  18
uaugauaaaa cgccgcagac acauau                26


<210>  19
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  19
uagaugauua ggcagagguu gaauau                26


<210>  20
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  20
tgauaaaacg ccgcagacat t                     21


<210>  21
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  21
tgaacaaaug gcacuaguat t                     21


<210>  22
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  22
tgcgucagca aacacuuggt t                     21


<210>  23
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  23
tgaaccacug aacaaauggt t                     21


<210>  24
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  24
taacgggcaa cauaccuugt t                     21


<210>  25
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  25
tacuaguaaa cugagccagt t                     21


<210>  26
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  26
tggacaaacg ggcaacauat t                     21


<210>  27
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  27
tacgggcaac auaccuugat t                     21


<210>  28
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  28
tgaagcgaag ugcacacggt t                     21


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  29
tuccgcggga uucagcgcct t                     21


<210>  30
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  30
aguccgcggg auucagcgcc gacuau                26


<210>  31
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  31
uuaaagagag gugcgcccgg ugguau                26


<210>  32
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  32
uaagcgaagu gcacacgguc cgguau                26


<210>  33
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  33
uugaagcgaa gugcacacgg accuau                26


<210>  34
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  34
agugaagcga agugcacacg gacuau                26


<210>  35
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  35
uagaggugaa gcgaagugca cacuau                26


<210>  36
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  36
ucagagguga agcgaagugc acauau                26


<210>  37
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  37
ugcagaggug aagcgaagug cacuau                26


<210>  38
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  38
ucggucguug acauugcugg gaguau                26


<210>  39
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  39
ucaaggucgg ucguugacau ugcuau                26


<210>  40
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  40
ugaccuuuaa ccuaaucucc uccuau                26


<210>  41
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  41
auuuaugccu acagccuccu aauuau                26


<210>  42
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  42
aauuuaugcc uacagccucc uaauau                26


<210>  43
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  43
uaauuuaugc cuacagccuc cuauau                26


<210>  44
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  44
ucaauuuaug ccuacagccu ccuuau                26


<210>  45
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  45
uccaauuuau gccuacagcc uccuau                26


<210>  46
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  46
uacgccgcag acacauccag cgauau                26


<210>  47
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  47
uaaaacgccg cagacacauc caguau                26


<210>  48
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  48
uuaaaacgcc gcagacacau ccauau                26


<210>  49
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  49
uugauaaaac gccgcagaca cauuau                26


<210>  50
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  50
uaaacgggca acauaccuug auauau                26


<210>  51
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  51
ucaaacgggc aacauaccuu gauuau                26


<210>  52
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  52
uacaaacggg caacauaccu ugauau                26


<210>  53
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  53
uaggacaaac gggcaacaua ccuuau                26


<210>  54
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  54
uggcacuagu aaacugagcc aaguau                26


<210>  55
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  55
uuggcacuag uaaacugagc caauau                26


<210>  56
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  56
uaauggcacu aguaaacuga gccuau                26


<210>  57
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  57
uaaauggcac uaguaaacug agcuau                26


<210>  58
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  58
ucaaauggca cuaguaaacu gaguau                26


<210>  59
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  59
uacaaauggc acuaguaaac ugauau                26


<210>  60
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  60
uugaacaaau ggcacuagua aacuau                26


<210>  61
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  61
acugaacaaa uggcacuagu aaauau                26


<210>  62
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  62
uaaccacuga acaaauggca cuauau                26


<210>  63
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  63
ucgaaccacu gaacaaaugg cacuau                26


<210>  64
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  64
ucagagguga aaaaguugca ugguau                26


<210>  65
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  65
ugcagaggug aaaaaguugc auguau                26


<210>  66
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  66
ugaugauuag gcagagguga aaauau                26


<210>  67
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  67
ugagaugauu aggcagaggu gaauau                26


<210>  68
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  68
ucacgagucu agacucugug guauau                26


<210>  69
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  69
auugagagaa guccaccacg aguuau                26


<210>  70
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  70
aauugagaga aguccaccac gaguau                26


<210>  71
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  71
uuagaaaauu gagagaaguc cacuau                26


<210>  72
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  72
uuauggaucg gcagaggagc cacuau                26


<210>  73
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  73
ucaguaugga ucggcagagg agcuau                26


<210>  74
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  74
uggaguuccg caguauggau cgguau                26


<210>  75
<211>  23
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  75
uaccaauuua ugccuacagg ccu                   23


<210>  76
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  76
uaccaauuua ugccuacagg c                     21


<210>  77
<211>  23
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  77
ugaagcgaag ugcacacgga ccg                   23


<210>  78
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  78
ugaagcgaag ugcacacgga c                     21


<210>  79
<211>  23
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  79
uggacaaacg ggcaacauac cuu                   23


<210>  80
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  80
uggacaaacg ggcaacauac c                     21


<210>  81
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  1-15
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  81
auaaaacgcc gcagatt                          17


<210>  82
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  82
ugugaagcga agugcacacu u                     21


<210>  83
<211>  23
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  83
uaaaauugag agaaguccac cac                   23


<210>  84
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  84
uugaagcgaa gugcacacgg accgcg                26


<210>  85
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  85
ugugaagcga agugcacacg gaccgc                26


<210>  86
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  86
ugauaaaacg ccgcagacac auccgc                26


<210>  87
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  87
uaugauaaaa cgccgcagac acacgc                26


<210>  88
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  88
agugaagcga agugcacacg gaccgc                26


<210>  89
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  89
aaugauaaaa cgccgcagac acacgc                26


<210>  90
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  90
ugaagcgaag ugcacacgga ccgcgc                26


<210>  91
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  91
uggacaaacg ggcaacauac cuucgc                26


<210>  92
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  92
uaccaauuua ugccuacagc cuccgc                26


<210>  93
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  1-15
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  93
ugauuaggca gaggutt                          17


<210>  94
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  1-15
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  94
aauuuaugcc uacagtt                          17


<210>  95
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  95
uaccaauuua ugccuacagu u                     21


<210>  96
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  96
auugagagaa guccaccacg a                     21


<210>  97
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  97
auugagagaa guccaccacu u                     21


<210>  98
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  98
uuugagagaa guccaccacg a                     21


<210>  99
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  99
aauugagaga aguccaccac g                     21


<210>  100
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  100
aauugagaga aguccaccau u                     21


<210>  101
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  101
uauugagaga aguccaccac g                     21


<210>  102
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<400>  102
uuagaaaauu gagagaaguc c                     21


<210>  103
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  103
uaucuguagg cauaaauugg uat                   23


<210>  104
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  104
uauucugcgg cguuuuauca uat                   23


<210>  105
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  105
uauaccucug ccuaaucauc uat                   23


<210>  106
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  106
cuguaggcau aaauugguat                       20


<210>  107
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  107
accucugccu aaucaucuat                       20


<210>  108
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  108
uuuacuagug ccauuuguat                       20


<210>  109
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  109
ucugcggcgu uuuaucauat                       20


<210>  110
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  110
uauuuuacua gugccauuug uat                   23


<210>  111
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  111
uauaugccug uaggcauaaa uuggua                26


<210>  112
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  112
uauauugucu gcggcguuuu aucaua                26


<210>  113
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  113
uauaucaacc ucugccuaau caucua                26


<210>  114
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  114
uauauugugu cugcggcguu uuauca                26


<210>  115
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  115
uauauuuuac uagugccauu uguuca                26


<210>  116
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  116
uauauugcca aguguuugcu gacgca                26


<210>  117
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  117
uauauugcca uuuguucagu gguuca                26


<210>  118
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  118
uauauaucaa gguauguugc ccguua                26


<210>  119
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  119
uauauuccug gcucaguuua cuagua                26


<210>  120
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  120
uauaugguau guugcccguu ugucca                26


<210>  121
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  121
uauauuauca agguauguug cccgua                26


<210>  122
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  122
uauauguccg ugugcacuuc gcuuca                26


<210>  123
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  123
uauugucugc ggcguuuuau cat                   23


<210>  124
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  124
uauuacuagu gccauuuguu cat                   23


<210>  125
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  125
uauccaagug uuugcugacg cat                   23


<210>  126
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  126
uauccauuug uucagugguu cat                   23


<210>  127
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  127
uaucaaggua uguugcccgu uat                   23


<210>  128
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  128
uaucuggcuc aguuuacuag uat                   23


<210>  129
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  129
uauuauguug cccguuuguc cat                   23


<210>  130
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  130
uauucaaggu auguugcccg uat                   23


<210>  131
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  131
uauccgugug cacuucgcuu cat                   23


<210>  132
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  132
uauggcgcug aaucccgcgg aat                   23


<210>  133
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  133
uauaucggcg cugaaucccg cggact                26


<210>  134
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  134
uauauaccgg gcgcaccucu cuuuaa                26


<210>  135
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  135
uauauggacc gugugcacuu cgcuua                26


<210>  136
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  136
uauauuccgu gugcacuucg cuucaa                26


<210>  137
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  137
uauauccgug ugcacuucgc uucact                26


<210>  138
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  138
uauaugugca cuucgcuuca ccucua                26


<210>  139
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  139
uauauugcac uucgcuucac cucuga                26


<210>  140
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  140
uauaugcacu ucgcuucacc ucugca                26


<210>  141
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  141
uauaucccag caaugucaac gaccga                26


<210>  142
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  142
uauauaaugu caacgaccga ccuuga                26


<210>  143
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  143
uauauaggag auuagguuaa agguca                26


<210>  144
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  144
uauauuagga ggcuguaggc auaaat                26


<210>  145
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  145
uauauaggag gcuguaggca uaaaut                26


<210>  146
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  146
uauauggagg cuguaggcau aaauua                26


<210>  147
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  147
uauaugaggc uguaggcaua aauuga                26


<210>  148
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  148
uauauaggcu guaggcauaa auugga                26


<210>  149
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  149
uauaugcugg augugucugc ggcgua                26


<210>  150
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  150
uauauggaug ugucugcggc guuuua                26


<210>  151
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  151
uauaugaugu gucugcggcg uuuuaa                26


<210>  152
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  152
uauauguguc ugcggcguuu uaucaa                26


<210>  153
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  153
uauauucaag guauguugcc cguuua                26


<210>  154
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  154
uauaucaagg uauguugccc guuuga                26


<210>  155
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  155
uauauaaggu auguugcccg uuugua                26


<210>  156
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  156
uauauguaug uugcccguuu guccua                26


<210>  157
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  157
uauauuggcu caguuuacua gugcca                26


<210>  158
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  158
uauauggcuc aguuuacuag ugccaa                26


<210>  159
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  159
uauaucucag uuuacuagug ccauua                26


<210>  160
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  160
uauauucagu uuacuagugc cauuua                26


<210>  161
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  161
uauaucaguu uacuagugcc auuuga                26


<210>  162
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  162
uauauaguuu acuagugcca uuugua                26


<210>  163
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  163
uauauuuacu agugccauuu guucaa                26


<210>  164
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  164
uauauuacua gugccauuug uucagt                26


<210>  165
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  165
uauaugugcc auuuguucag ugguua                26


<210>  166
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  166
gguggacuuc ucucaauuuu a                     21


<210>  167
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  167
uauaugccau uuguucagug guucga                26


<210>  168
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  168
uauauaugca acuuuuucac cucuga                26


<210>  169
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  169
uauauugcaa cuuuuucacc ucugca                26


<210>  170
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  170
uauauuucac cucugccuaa ucauca                26


<210>  171
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  171
uauaucaccu cugccuaauc aucuca                26


<210>  172
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  172
uauauccaca gagucuagac ucguga                26


<210>  173
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  173
uauauucgug guggacuucu cucaat                26


<210>  174
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  174
uauaucgugg uggacuucuc ucaaut                26


<210>  175
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  175
uauauggacu ucucucaauu uucuaa                26


<210>  176
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  176
uauauggcuc cucugccgau ccauaa                26


<210>  177
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  177
uauauuccuc ugccgaucca uacuga                26


<210>  178
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  178
uauaugaucc auacugcgga acucca                26


<210>  179
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  179
uugccuguag gcauaaauug guaut                 25


<210>  180
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  180
uuguccgugu gcacuucgcu ucaut                 25


<210>  181
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  181
uugguauguu gcccguuugu ccaut                 25


<210>  182
<211>  19
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  182
gugugcacuu cgcuucaca                        19


<210>  183
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19,21
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  183
gguggacuuc ucucaauuut a                     21


<210>  184
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  184
cgcgguccgu gugcacuucg cuucaa                26


<210>  185
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  185
gcgguccgug ugcacuucgc uucaca                26


<210>  186
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  186
gcggaugugu cugcggcguu uuauca                26


<210>  187
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-24,26
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  187
gcgugugucu gcggcguuuu aucata                26


<210>  188
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-25
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  188
gcgguccgug ugcacuucgc uucact                26


<210>  189
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-24
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  189
gcgugugucu gcggcguuuu aucatt                26


<210>  190
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  190
gcgcgguccg ugugcacuuc gcuuca                26


<210>  191
<211>  26
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  191
gcgaagguau guugcccguu ugucca                26


<210>  192
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-24,26
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  192
gcggaggcug uaggcauaaa uuggta                26


<210>  193
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-18
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  193
uguaggcaua aauugguat                        19


<210>  194
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-18
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  194
ccucugccua aucaucuat                        19


<210>  195
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-18
<223>  /mod_base = "2'-hydroxy nucleoside"

<400>  195
cugcggcguu uuaucauat                        19


<210>  196
<211>  22
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  196
cuguaggcau aaauugguau un                    22


<210>  197
<211>  22
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  197
gccuguaggc auaaauuggu an                    22


<210>  198
<211>  21
<212>  RNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<400>  198
gccuguaggc auaaauuggu a                     21


<210>  199
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19,21
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  199
gccuguaggc auaaauuggt an                    22


<210>  200
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  200
aacuguaggc auaaauuggu an                    22


<210>  201
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  201
ucguggugga cuucucucaa un                    22


<210>  202
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  202
aaguggugga cuucucucaa un                    22


<210>  203
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-20
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  203
ucguggugga cuucucucaa tn                    22


<210>  204
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  204
cgugguggac uucucucaau un                    22


<210>  205
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  205
aaugguggac uucucucaau un                    22


<210>  206
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  206
cgugguggac uucucucaat tn                    22


<210>  207
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  207
ggacuucucu caauuuucua an                    22


<210>  208
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  208
cgugguggac uucucucaau an                    22


<210>  209
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "abasic site"

<400>  209
ucguggugga cuucucucaa an                    22


<210>  210
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  210
taccaauuua ugccuacagt t                     21


<210>  211
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  211
taugauaaaa cgccgcagat t                     21


<210>  212
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  212
tagaugauua ggcagaggut t                     21


<210>  213
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  213
tacaaauggc acuaguaaat t                     21


<210>  214
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  214
taccaauuua ugccuacagt t                     21


<210>  215
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  215
taccaauuua ugccuacagt t                     21


<210>  216
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  216
tagaugauua ggcagaggut t                     21


<210>  217
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  217
tagaugauua ggcagaggut t                     21


<210>  218
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  218
taccaauuua ugccuacagt t                     21


<210>  219
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  219
tagaugauua ggcagaggut t                     21


<210>  220
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  220
taccaauuua ugccuacagt t                     21


<210>  221
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  221
taccaauuua ugccuacagt t                     21


<210>  222
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  222
tagaugauua ggcagaggut t                     21


<210>  223
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  223
tagaugauua ggcagaggut t                     21


<210>  224
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  224
tacaaauggc acuaguaaat t                     21


<210>  225
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  225
tacaaauggc acuaguaaat t                     21


<210>  226
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  226
tacaaauggc acuaguaaat t                     21


<210>  227
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  227
tacaaauggc acuaguaaat t                     21


<210>  228
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  228
tacaaauggc acuaguaaat t                     21


<210>  229
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  229
tacaaauggc acuaguaaat t                     21


<210>  230
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  230
taugauaaaa cgccgcagat t                     21


<210>  231
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  231
taugauaaaa cgccgcagat t                     21


<210>  232
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  232
taugauaaaa cgccgcagat t                     21


<210>  233
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  233
taugauaaaa cgccgcagat t                     21


<210>  234
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  234
taugauaaaa cgccgcagat t                     21


<210>  235
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  235
taugauaaaa cgccgcagat t                     21


<210>  236
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  236
taccaauuua ugccuacagt t                      21


<210>  237
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  237
taccaauuua ugccuacagt t                     21


<210>  238
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  238
tagaugauua ggcagaggut t                     21


<210>  239
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  239
tagaugauua ggcagaggut t                     21


<210>  240
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  240
tacaaauggc acuaguaaat t                     21


<210>  241
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  241
tacaaauggc acuaguaaat t                     21


<210>  242
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  242
taugauaaaa cgccgcagat t                     21


<210>  243
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  243
taugauaaaa cgccgcagat t                     21


<210>  244
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  244
taccaauuua ugccuacagt t                     21


<210>  245
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  245
tagaugauua ggcagaggut t                     21


<210>  246
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  246
tacaaauggc acuaguaaat t                     21


<210>  247
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  247
taugauaaaa cgccgcagat t                     21


<210>  248
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  248
taccaauuua ugccuacagg ccuuau                26


<210>  249
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  249
taccaauuua ugccuacagg ccuuau                26


<210>  250
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  250
taccaauuua ugccuacagg ccuuau                26


<210>  251
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  251
taccaauuua ugccuacagg ccuuau                26


<210>  252
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  252
taugauaaaa cgccgcagac acauau                26


<210>  253
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  253
taugauaaaa cgccgcagac acauau                26


<210>  254
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  254
taugauaaaa cgccgcagac acauau                26


<210>  255
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  255
taugauaaaa cgccgcagac acauau                26


<210>  256
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  256
tagaugauua ggcagagguu gaauau                26


<210>  257
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  257
tagaugauua ggcagagguu gaauau                26


<210>  258
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  258
tagaugauua ggcagagguu gaauau                26


<210>  259
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,16,18,20,23,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  259
tagaugauua ggcagagguu gaauau                26


<210>  260
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  260
taccaauuua ugccuacagt t                     21


<210>  261
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  261
taugauaaaa cgccgcagat t                     21


<210>  262
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  262
tagaugauua ggcagaggut t                     21


<210>  263
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  263
taugauaaaa cgccgcagat t                     21


<210>  264
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  264
taugauaaaa cgccgcagat t                     21


<210>  265
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  265
taccaauuua ugccuacagt t                     21


<210>  266
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "phosphate modified nucleoside"

<400>  266
tagaugauua ggcagaggut t                     21


<210>  267
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  267
ugauaaaacg ccgcagacac aucuau                26


<210>  268
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  268
ugaacaaaug gcacuaguaa acuuau                26


<210>  269
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  269
ugcgucagca aacacuuggc acauau                26


<210>  270
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  270
ugaaccacug aacaaauggc acuuau                26


<210>  271
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  271
uaacgggcaa cauaccuuga uaauau                26


<210>  272
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  272
uacuaguaaa cugagccagg agauau                26


<210>  273
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  273
uggacaaacg ggcaacauac cuuuau                26


<210>  274
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  274
uacgggcaac auaccuugau aauuau                26


<210>  275
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  275
ugaagcgaag ugcacacgga ccguau                26


<210>  276
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  276
ugauaaaacg ccgcagacac aucuau                26


<210>  277
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  277
ugaacaaaug gcacuaguaa acuuau                26


<210>  278
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  278
ugcgucagca aacacuuggc acauau                26


<210>  279
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  279
ugaaccacug aacaaauggc acuuau                26


<210>  280
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  280
uaacgggcaa cauaccuuga uaauau                26


<210>  281
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  281
uacuaguaaa cugagccagg agauau                26


<210>  282
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  282
uggacaaacg ggcaacauac cuuuau                26


<210>  283
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  283
uacgggcaac auaccuugau aauuau                26


<210>  284
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  284
ugaagcgaag ugcacacgga ccguau                26


<210>  285
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  285
uaccaauuua ugccuacagg ccuuau                26


<210>  286
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  286
uaccaauuua ugccuacagg ccuuau                26


<210>  287
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  287
uaugauaaaa cgccgcagac acauau                26


<210>  288
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  288
uaugauaaaa cgccgcagac acauau                26


<210>  289
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,13,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  289
uagaugauua ggcagagguu gaauau                26


<210>  290
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,15,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,16,17,19,21,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  290
uagaugauua ggcagagguu gaauau                26


<210>  291
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  291
tgauaaaacg ccgcagacat t                     21


<210>  292
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  292
tgaacaaaug gcacuaguat t                     21


<210>  293
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  293
tgcgucagca aacacuuggt t                     21


<210>  294
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  294
tgaaccacug aacaaauggt t                     21


<210>  295
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  295
taacgggcaa cauaccuugt t                     21


<210>  296
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  296
tacuaguaaa cugagccagt t                     21


<210>  297
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  297
tggacaaacg ggcaacauat t                     21


<210>  298
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  298
tacgggcaac auaccuugat t                     21


<210>  299
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  299
tgaagcgaag ugcacacggt t                     21


<210>  300
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  300
tuccgcggga uucagcgcct t                     21


<210>  301
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  301
ugaacaaaug gcacuaguaa acuuau                26


<210>  302
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  302
uggacaaacg ggcaacauac cuuuau                26


<210>  303
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  303
ugaagcgaag ugcacacgga ccguau                26


<210>  304
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  304
uaccaauuua ugccuacagg ccuuau                26


<210>  305
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  305
uagaugauua ggcagagguu gaauau                26


<210>  306
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  306
ugaacaaaug gcacuaguaa acuuau                26


<210>  307
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  307
uggacaaacg ggcaacauac cuuuau                26


<210>  308
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  308
ugaagcgaag ugcacacgga ccguau                26


<210>  309
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  309
uaccaauuua ugccuacagg ccuuau                26


<210>  310
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  310
uagaugauua ggcagagguu gaauau                26


<210>  311
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  311
uggacaaacg ggcaacauac cuuuau                26


<210>  312
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  312
uggacaaacg ggcaacauac cuuuau                26


<210>  313
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  313
uaugauaaaa cgccgcagac acauau                26


<210>  314
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  314
uaugauaaaa cgccgcagac acauau                26


<210>  315
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  315
ugauaaaacg ccgcagacac aucuau                26


<210>  316
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  316
ugauaaaacg ccgcagacac aucuau                26


<210>  317
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  317
uggacaaacg ggcaacauac cuuuau                26


<210>  318
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  318
uaccaauuua ugccuacagg ccuuau                26


<210>  319
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "phosphate modified nucleoside"

<400>  319
taccaauuua ugccuacagt t                     21


<210>  320
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  320
aguccgcggg auucagcgcc gacuau                26


<210>  321
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  321
uuaaagagag gugcgcccgg ugguau                26


<210>  322
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  322
uaagcgaagu gcacacgguc cgguau                26


<210>  323
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  323
uugaagcgaa gugcacacgg accuau                26


<210>  324
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  324
agugaagcga agugcacacg gacuau                26


<210>  325
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  325
uagaggugaa gcgaagugca cacuau                26


<210>  326
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  326
ucagagguga agcgaagugc acauau                26


<210>  327
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  327
ugcagaggug aagcgaagug cacuau                26


<210>  328
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  328
ucggucguug acauugcugg gaguau                26


<210>  329
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  329
ucaaggucgg ucguugacau ugcuau                26


<210>  330
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  330
ugaccuuuaa ccuaaucucc uccuau                26


<210>  331
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  331
auuuaugccu acagccuccu aauuau                26


<210>  332
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  332
aauuuaugcc uacagccucc uaauau                26


<210>  333
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  333
uaauuuaugc cuacagccuc cuauau                26


<210>  334
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  334
ucaauuuaug ccuacagccu ccuuau                26


<210>  335
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  335
uccaauuuau gccuacagcc uccuau                26


<210>  336
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  336
uacgccgcag acacauccag cgauau                26


<210>  337
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  337
uaaaacgccg cagacacauc caguau                26


<210>  338
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  338
uuaaaacgcc gcagacacau ccauau                26


<210>  339
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  339
uugauaaaac gccgcagaca cauuau                26


<210>  340
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  340
uacgggcaac auaccuugau aauuau                26


<210>  341
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  341
uaacgggcaa cauaccuuga uaauau                26


<210>  342
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  342
uaaacgggca acauaccuug auauau                26


<210>  343
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  343
ucaaacgggc aacauaccuu gauuau                26


<210>  344
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  344
uacaaacggg caacauaccu ugauau                26


<210>  345
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  345
uaggacaaac gggcaacaua ccuuau                26


<210>  346
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  346
uacuaguaaa cugagccagg agauau                26


<210>  347
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  347
uggcacuagu aaacugagcc aaguau                26


<210>  348
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  348
uuggcacuag uaaacugagc caauau                26


<210>  349
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  349
uaauggcacu aguaaacuga gccuau                26


<210>  350
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  350
uaaauggcac uaguaaacug agcuau                26


<210>  351
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  351
ucaaauggca cuaguaaacu gaguau                26


<210>  352
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  352
uacaaauggc acuaguaaac ugauau                26


<210>  353
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  353
uugaacaaau ggcacuagua aacuau                26


<210>  354
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  354
acugaacaaa uggcacuagu aaauau                26


<210>  355
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  355
uaaccacuga acaaauggca cuauau                26


<210>  356
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  356
ugaaccacug aacaaauggc acuuau                26


<210>  357
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  357
ucgaaccacu gaacaaaugg cacuau                26


<210>  358
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  358
ucagagguga aaaaguugca ugguau                26


<210>  359
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  359
ugcagaggug aaaaaguugc auguau                26


<210>  360
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  360
ugaugauuag gcagagguga aaauau                26


<210>  361
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  361
ugagaugauu aggcagaggu gaauau                26


<210>  362
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  362
ucacgagucu agacucugug guauau                26


<210>  363
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  363
auugagagaa guccaccacg aguuau                26


<210>  364
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  364
aauugagaga aguccaccac gaguau                26


<210>  365
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  365
uuagaaaauu gagagaaguc cacuau                26


<210>  366
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  366
ugcgucagca aacacuuggc acauau                26


<210>  367
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  367
uuauggaucg gcagaggagc cacuau                26


<210>  368
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  368
ucaguaugga ucggcagagg agcuau                26


<210>  369
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,23,24
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  369
uggaguuccg caguauggau cgguau                26


<210>  370
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  370
uaccaauuua ugccuacagg ccu                   23


<210>  371
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  371
uaccaauuua ugccuacagg ccu                   23


<210>  372
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  372
uaccaauuua ugccuacagg c                     21


<210>  373
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  373
ugaagcgaag ugcacacgga ccg                   23


<210>  374
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  374
ugaagcgaag ugcacacgga ccg                   23


<210>  375
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  375
ugaagcgaag ugcacacgga c                     21


<210>  376
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  376
uggacaaacg ggcaacauac cuu                   23


<210>  377
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  377
uggacaaacg ggcaacauac cuu                   23


<210>  378
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  378
uggacaaacg ggcaacauac c                     21


<210>  379
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand	2,4,6,10,12,14,	1,3,5,7,8,9,11,13,15

<220>  
<221>  modified base
<222>  17
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  379
auaaaacgcc gcagatt                          17


<210>  380
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,6,8,9,14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,7,10,11,12,13,15,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,20,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  380
ugugaagcga agugcacacu u                     21


<210>  381
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,6,8,9,14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,4,5,7,10,11,12,13,15,17,18,19,20,21,22,23
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  381
uaaaauugag agaaguccac cac                   23


<210>  382
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  382
uugaagcgaa gugcacacgg accgcg                26


<210>  383
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  383
uugaagcgaa gugcacacgg accgcg                26


<210>  384
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  384
ugugaagcga agugcacacg gaccgc                26


<210>  385
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  385
ugugaagcga agugcacacg gaccgc                26


<210>  386
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  386
ugauaaaacg ccgcagacac auccgc                26


<210>  387
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  387
ugauaaaacg ccgcagacac auccgc                26


<210>  388
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  388
uaugauaaaa cgccgcagac acacgc                26


<210>  389
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  389
uaugauaaaa cgccgcagac acacgc                26


<210>  390
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  390
agugaagcga agugcacacg gaccgc                26


<210>  391
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  391
aaugauaaaa cgccgcagac acacgc                26


<210>  392
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  392
ugaagcgaag ugcacacgga ccgcgc                26


<210>  393
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  393
ugaagcgaag ugcacacgga ccgcgc                26


<210>  394
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  394
uggacaaacg ggcaacauac cuucgc                26


<210>  395
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  395
uggacaaacg ggcaacauac cuucgc                26


<210>  396
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  396
uaccaauuua ugccuacagc cuccgc                26


<210>  397
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,22,23
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  397
uaccaauuua ugccuacagc cuccgc                26


<210>  398
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  17
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  398
aauuuaugcc uacagtt                          17


<210>  399
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  17
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  399
ugauuaggca gaggutt                          17


<210>  400
<211>  17
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,10,12,14
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  17
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  400
aauuuaugcc uacagtt                          17


<210>  401
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  401
uaccaauuua ugccuacagu u                     21


<210>  402
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  402
uaccaauuua ugccuacagg c                     21


<210>  403
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  403
uaccaauuua ugccuacagg c                     21


<210>  404
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  404
uaccaauuua ugccuacagu u                     21


<210>  405
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  405
auugagagaa guccaccacg a                     21


<210>  406
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  406
auugagagaa guccaccacg a                     21


<210>  407
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  407
auugagagaa guccaccacu u                     21


<210>  408
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  408
uuugagagaa guccaccacg a                     21


<210>  409
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  409
aauugagaga aguccaccac g                     21


<210>  410
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  410
aauugagaga aguccaccac g                     21


<210>  411
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  411
aauugagaga aguccaccau u                     21


<210>  412
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  412
uauugagaga aguccaccac g                     21


<210>  413
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<400>  413
uuagaaaauu gagagaaguc c                     21


<210>  414
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger antisense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3,4,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "vinyl phophonate modified nucleoside"

<400>  414
uuagaaaauu gagagaaguc c                     21


<210>  415
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-ALNY modifed nucleoside"

<400>  415
uaucuguagg cauaaauugg uat                   23


<210>  416
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-ALNY modifed nucleoside"

<400>  416
uauucugcgg cguuuuauca uat                   23


<210>  417
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-ALNY modifed nucleoside"

<400>  417
uauaccucug ccuaaucauc uat                   23


<210>  418
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Toc modifed nucleoside"

<400>  418
uauaccucug ccuaaucauc uat                   23


<210>  419
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  419
uauaccucug ccuaaucauc uat                   23


<210>  420
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  420
uaucuguagg cauaaauugg uat                   23


<210>  421
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  421
uauaccucug ccuaaucauc uat                   23


<210>  422
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  422
guguaggcau aaauugguat                       20


<210>  423
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  423
cccucugccu aaucaucuat                       20


<210>  424
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  424
uuuacuagug ccauuuguat                       20


<210>  425
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  425
uaucuguagg cauaaauugg uat                   23


<210>  426
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  426
uauaccucug ccuaaucauc uat                   23


<210>  427
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  427
uaucuguagg cauaaauugg uat                   23


<210>  428
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  428
uauaccucug ccuaaucauc uat                   23


<210>  429
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,5,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  429
guguaggcau aaauugguat                       20


<210>  430
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,5,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  430
cccucugccu aaucaucuat                       20


<210>  431
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,7,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  431
cccucugccu aaucaucuat                       20


<210>  432
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,9,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  432
cccucugccu aaucaucuat                       20


<210>  433
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,11,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  433
cccucugccu aaucaucuat                       20


<210>  434
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,13,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  434
cccucugccu aaucaucuat                       20


<210>  435
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,6,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  435
cccucugccu aaucaucuat                       20


<210>  436
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  436
cccucugccu aaucaucuat                       20


<210>  437
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,10,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  437
cccucugccu aaucaucuat                       20


<210>  438
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  438
cccucugccu aaucaucuat                       20


<210>  439
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  439
cccucugccu aaucaucuat                       20


<210>  440
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  440
cuguaggcau aaauugguat                       20


<210>  441
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  441
guguaggcau aaauugguat                       20


<210>  442
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  442
accucugccu aaucaucuat                       20


<210>  443
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-3' seco nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  443
cccucugccu aaucaucuat                       20


<210>  444
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  444
cuguaggcau aaauugguat                       20


<210>  445
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  445
accucugccu aaucaucuat                       20


<210>  446
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "TEG-Biotin modified nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  446
uaucuguagg cauaaauugg uat                   23


<210>  447
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "TEG-Biotin modified nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  447
uauaccucug ccuaaucauc uat                   23


<210>  448
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  448
guguaggcau aaauugguat                       20


<210>  449
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  449
guguaggcau aaauugguat                       20


<210>  450
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  450
cccucugccu aaucaucuat                       20


<210>  451
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  451
uuuacuagug ccauuuguat                       20


<210>  452
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  452
uuuacuagug ccauuuguat                       20


<210>  453
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  453
cuguaggcau aaauugguat                       20


<210>  454
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  454
accucugccu aaucaucuat                       20


<210>  455
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  455
uuuacuagug ccauuuguat                       20


<210>  456
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  456
ucugcggcgu uuuaucauat                       20


<210>  457
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  457
ucugcggcgu uuuaucauat                       20


<210>  458
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  458
ucugcggcgu uuuaucauat                       20


<210>  459
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NH2-C6 modified nucleoside"

<400>  459
ucugcggcgu uuuaucauat                       20


<210>  460
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  460
accucugccu aaucaucuat                       20


<210>  461
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  461
accucugccu aaucaucuat                       20


<210>  462
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  462
cuguaggcau aaauugguat                       20


<210>  463
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  463
cuguaggcau aaauugguat                       20


<210>  464
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  464
uuuacuagug ccauuuguat                       20


<210>  465
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  465
ucugcggcgu uuuaucauat                       20


<210>  466
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  466
cuguaggcau aaauugguat                       20


<210>  467
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  467
accucugccu aaucaucuat                       20


<210>  468
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  468
uuuacuagug ccauuuguat                       20


<210>  469
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18,19
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Alk-SS-C6 modified nucleoside"

<400>  469
ucugcggcgu uuuaucauat                       20


<210>  470
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  470
uaucuguagg cauaaauugg uat                   23


<210>  471
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  471
uauaccucug ccuaaucauc uat                   23


<210>  472
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  472
uauuuuacua gugccauuug uat                   23


<210>  473
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  473
uauucugcgg cguuuuauca uat                   23


<210>  474
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  474
uaucuguagg cauaaauugg uat                   23


<210>  475
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  475
uauaccucug ccuaaucauc uat                   23


<210>  476
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  476
uauuuuacua gugccauuug uat                   23


<210>  477
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  477
uauucugcgg cguuuuauca uat                   23


<210>  478
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  478
uauaugccug uaggcauaaa uuggua                26


<210>  479
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  479
uauaugccug uaggcauaaa uuggua                26


<210>  480
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  480
uauaugccug uaggcauaaa uuggua                26


<210>  481
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  481
uauaugccug uaggcauaaa uuggua                26


<210>  482
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  482
uauauugucu gcggcguuuu aucaua                26


<210>  483
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  483
uauauugucu gcggcguuuu aucaua                26


<210>  484
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  484
uauauugucu gcggcguuuu aucaua                26


<210>  485
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  485
uauauugucu gcggcguuuu aucaua                26


<210>  486
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  486
uauaucaacc ucugccuaau caucua                26


<210>  487
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  487
uauaucaacc ucugccuaau caucua                26


<210>  488
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7,25,26
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  488
uauaucaacc ucugccuaau caucua                26


<210>  489
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,13,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  489
uauaucaacc ucugccuaau caucua                26


<210>  490
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  490
ucugcggcgu uuuaucauat                       20


<210>  491
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  491
ucugcggcgu uuuaucauat                       20


<210>  492
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  492
uauucugcgg cguuuuauca uat                   23


<210>  493
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  493
cuguaggcau aaauugguat                       20


<210>  494
<211>  20
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  2,4,6,10,12,14,16,18
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "inverted nucleotide"

<400>  494
accucugccu aaucaucuat                       20


<210>  495
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  495
uauauugugu cugcggcguu uuauca                26


<210>  496
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  496
uauauuuuac uagugccauu uguuca                26


<210>  497
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  497
uauauugcca aguguuugcu gacgca                26


<210>  498
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  498
uauauugcca uuuguucagu gguuca                26


<210>  499
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  499
uauauaucaa gguauguugc ccguua                26


<210>  500
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  500
uauauuccug gcucaguuua cuagua                26


<210>  501
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  501
uauaugguau guugcccguu ugucca                26


<210>  502
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  502
uauauuauca agguauguug cccgua                26


<210>  503
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  503
uauauguccg ugugcacuuc gcuuca                26


<210>  504
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  504
uauauugugu cugcggcguu uuauca                26


<210>  505
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  505
uauauuuuac uagugccauu uguuca                26


<210>  506
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  506
uauauugcca aguguuugcu gacgca                26


<210>  507
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  507
uauauugcca uuuguucagu gguuca                26


<210>  508
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  508
uauauaucaa gguauguugc ccguua                26


<210>  509
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  509
uauauuccug gcucaguuua cuagua                26


<210>  510
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  510
uauaugguau guugcccguu ugucca                26


<210>  511
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  511
uauauuauca agguauguug cccgua                26


<210>  512
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  512
uauauguccg ugugcacuuc gcuuca                26


<210>  513
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  513
uauaugccug uaggcauaaa uuggua                26


<210>  514
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C11-PEG3-NAG3 modified nucleoside"

<400>  514
uauaugccug uaggcauaaa uuggua                26


<210>  515
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  515
uauaugccug uaggcauaaa uuggua                26


<210>  516
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  516
uauauugucu gcggcguuuu aucaua                26


<210>  517
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C11-PEG3-NAG3 modified nucleoside"

<400>  517
uauauugucu gcggcguuuu aucaua                26


<210>  518
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  518
uauauugucu gcggcguuuu aucaua                26


<210>  519
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  519
uauaucaacc ucugccuaau caucua                26


<210>  520
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C11-PEG3-NAG3 modified nucleoside"

<400>  520
uauaucaacc ucugccuaau caucua                26


<210>  521
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "C6-SS-Alk-Me modified nucleoside"

<400>  521
uauaucaacc ucugccuaau caucua                26


<210>  522
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  522
uauugucugc ggcguuuuau cat                   23


<210>  523
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  523
uauuacuagu gccauuuguu cat                   23


<210>  524
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  524
uauccaagug uuugcugacg cat                   23


<210>  525
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  525
uauccauuug uucagugguu cat                   23


<210>  526
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  526
uaucaaggua uguugcccgu uat                   23


<210>  527
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  527
uaucuggcuc aguuuacuag uat                   23


<210>  528
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  528
uauuauguug cccguuuguc cat                   23


<210>  529
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  529
uauucaaggu auguugcccg uat                   23


<210>  530
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  530
uauccgugug cacuucgcuu cat                   23


<210>  531
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  531
uauggcgcug aaucccgcgg aat                   23


<210>  532
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  532
uauauuuuac uagugccauu uguuca                26


<210>  533
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  533
uauauuuuac uagugccauu uguuca                26


<210>  534
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  10,14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  534
uauauuuuac uagugccauu uguuca                26


<210>  535
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  535
uauaugguau guugcccguu ugucca                26


<210>  536
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  536
uauaugguau guugcccguu ugucca                26


<210>  537
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  537
uauaugguau guugcccguu ugucca                26


<210>  538
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  538
uauauguccg ugugcacuuc gcuuca                26


<210>  539
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  8,14,16,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,9,10,11,12,13,15,17,18,19,21,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  539
uauauguccg ugugcacuuc gcuuca                26


<210>  540
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  540
uauauguccg ugugcacuuc gcuuca                26


<210>  541
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  541
uauaugccug uaggcauaaa uuggua                26


<210>  542
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  8,14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  542
uauaugccug uaggcauaaa uuggua                26


<210>  543
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  543
uauaugccug uaggcauaaa uuggua                26


<210>  544
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  544
uauaucaacc ucugccuaau caucua                26


<210>  545
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  6,10,12,14,16,24
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,8,9,11,13,15,17,18,19,20,21,22,23,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  545
uauaucaacc ucugccuaau caucua                26


<210>  546
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  546
uauaucaacc ucugccuaau caucua                26


<210>  547
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  547
uauauuuuac uagugccauu uguuca                26


<210>  548
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  548
uauaugguau guugcccguu ugucca                26


<210>  549
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  549
uauauguccg ugugcacuuc gcuuca                26


<210>  550
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  550
uauaugccug uaggcauaaa uuggua                26


<210>  551
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  551
uauaucaacc ucugccuaau caucua                26


<210>  552
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  7,8
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  552
uauauugucu gcggcguuuu aucaua                26


<210>  553
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  7,8
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  553
uauauugucu gcggcguuuu aucaua                26


<210>  554
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  7,8
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  554
uauauugugu cugcggcguu uuauca                26


<210>  555
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  14,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  7,8
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  555
uauauugugu cugcggcguu uuauca                26


<210>  556
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "TEG-Biotin modified nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "Chol-TEG modifed nucleoside"

<400>  556
uauucugcgg cguuuuauca uat                   23


<210>  557
<211>  23
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2
<223>  /mod_base = "2'-hydroxy nucleoside"

<220>  
<221>  modified base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  23
<223>  /mod_base = "TEG-Biotin modified nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = " Chol-C6 modified nucleoside"

<400>  557
uaucuguagg cauaaauugg uat                   23


<210>  558
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  558
uauaucggcg cugaaucccg cggact                26


<210>  559
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  559
uauauaccgg gcgcaccucu cuuuaa                26


<210>  560
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  560
uauauggacc gugugcacuu cgcuua                26


<210>  561
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  561
uauauuccgu gugcacuucg cuucaa                26


<210>  562
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  562
uauauccgug ugcacuucgc uucact                26


<210>  563
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  563
uauaugugca cuucgcuuca ccucua                26


<210>  564
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  564
uauauugcac uucgcuucac cucuga                26


<210>  565
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  565
uauaugcacu ucgcuucacc ucugca                26


<210>  566
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  566
uauaucccag caaugucaac gaccga                26


<210>  567
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  567
uauauaaugu caacgaccga ccuuga                26


<210>  568
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  568
uauauaggag auuagguuaa agguca                26


<210>  569
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  569
uauauuagga ggcuguaggc auaaat                26


<210>  570
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  570
uauauaggag gcuguaggca uaaaut                26


<210>  571
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  571
uauauggagg cuguaggcau aaauua                26


<210>  572
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  572
uauaugaggc uguaggcaua aauuga                26


<210>  573
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  573
uauauaggcu guaggcauaa auugga                26


<210>  574
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  574
uauaugcugg augugucugc ggcgua                26


<210>  575
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  575
uauauggaug ugucugcggc guuuua                26


<210>  576
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  576
uauaugaugu gucugcggcg uuuuaa                26


<210>  577
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  577
uauauguguc ugcggcguuu uaucaa                26


<210>  578
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  578
uauauuauca agguauguug cccgua                26


<210>  579
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  579
uauauaucaa gguauguugc ccguua                26


<210>  580
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  580
uauauucaag guauguugcc cguuua                26


<210>  581
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  581
uauaucaagg uauguugccc guuuga                26


<210>  582
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  582
uauauaaggu auguugcccg uuugua                26


<210>  583
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  583
uauauguaug uugcccguuu guccua                26


<210>  584
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  584
uauauuccug gcucaguuua cuagua                26


<210>  585
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  585
uauauuggcu caguuuacua gugcca                26


<210>  586
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  586
uauauggcuc aguuuacuag ugccaa                26


<210>  587
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  587
uauaucucag uuuacuagug ccauua                26


<210>  588
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  588
uauauucagu uuacuagugc cauuua                26


<210>  589
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  589
uauaucaguu uacuagugcc auuuga                26


<210>  590
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  590
uauauaguuu acuagugcca uuugua                26


<210>  591
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  591
uauauuuacu agugccauuu guucaa                26


<210>  592
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  592
uauauuacua gugccauuug uucagt                26


<210>  593
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  593
uauaugugcc auuuguucag ugguua                26


<210>  594
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  594
uauauugcca uuuguucagu gguuca                26


<210>  595
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  595
uauaugccau uuguucagug guucga                26


<210>  596
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  596
uauauaugca acuuuuucac cucuga                26


<210>  597
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  597
uauauugcaa cuuuuucacc ucugca                26


<210>  598
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  598
uauauuucac cucugccuaa ucauca                26


<210>  599
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  599
uauaucaccu cugccuaauc aucuca                26


<210>  600
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  600
uauauccaca gagucuagac ucguga                26


<210>  601
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  601
uauauucgug guggacuucu cucaat                26


<210>  602
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  602
uauaucgugg uggacuucuc ucaaut                26


<210>  603
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  603
uauauggacu ucucucaauu uucuaa                26


<210>  604
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  604
uauauugcca aguguuugcu gacgca                26


<210>  605
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  605
uauauggcuc cucugccgau ccauaa                26


<210>  606
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  606
uauauuccuc ugccgaucca uacuga                26


<210>  607
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  607
uauaugaucc auacugcgga acucca                26


<210>  608
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  11,12,13
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,14,15,16,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  3,4,25
<223>  /mod_base = "phosphorothioate linked nucleoside"	 

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  608
uugccuguag gcauaaauug guaut                 25


<210>  609
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  6,7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  609
uauaugccug uaggcauaaa uuggua                26


<210>  610
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  11,12,13
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,14,15,16,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  3,4,25
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  610
uuguccgugu gcacuucgcu ucaut                 25


<210>  611
<211>  25
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  11,12,13
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,14,15,16,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  3,4,25
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  611
uugguauguu gcccguuugu ccaut                 25


<210>  612
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  5,7,8,9
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,6,10,11,12,13,14,15,16,17,18,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  612
gugugcacuu cgcuucaca                        19


<210>  613
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  7,9,10,11,16,17
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,8,12,13,14,15,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  2,3
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "NAG13 modified nucleoside"

<400>  613
gguggacuuc ucucaauuuu a                     21


<210>  614
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  5,7,8,9
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,6,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  18
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  2,3
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  614
gugugcacuu cgcuucaca                        19


<210>  615
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  7,9,10,11,16,17
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,8,12,13,14,15,18,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  20
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  2,3
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  615
gguggacuuc ucucaauuut a                     21


<210>  616
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  616
cgcgguccgu gugcacuucg cuucaa                26


<210>  617
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  617
gcgguccgug ugcacuucgc uucaca                26


<210>  618
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  618
gcggaugugu cugcggcguu uuauca                26


<210>  619
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  619
gcgugugucu gcggcguuuu aucata                26


<210>  620
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  620
gcgguccgug ugcacuucgc uucact                26


<210>  621
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  621
gcgugugucu gcggcguuuu aucatt                26


<210>  622
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  622
gcgcgguccg ugugcacuuc gcuuca                26


<210>  623
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  623
gcgaagguau guugcccguu ugucca                26


<210>  624
<211>  26
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  26
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  7
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  624
gcggaggcug uaggcauaaa uuggta                26


<210>  625
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "inverted nucleotide"

<400>  625
uguaggcaua aauugguat                        19


<210>  626
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "inverted nucleotide"

<400>  626
ccucugccua aucaucuat                        19


<210>  627
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4,6,7,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,9,11,13,15,17
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "inverted nucleotide"

<400>  627
cugcggcguu uuaucauat                        19


<210>  628
<211>  19
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  2,4,6,7,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,3,5,9,11,13,15,17
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  19
<223>  /mod_base = "inverted nucleotide"

<400>  628
uguaggcaua aauugguat                        19


<210>  629
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  7,8,9
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,10,11,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  629
cuguaggcau aaauugguau un                    22


<210>  630
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  630
gccuguaggc auaaauuggu an                    22


<210>  631
<211>  21
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "inverted nucleotide"

<220>  
<221>  modified base
<222>  1,2,21
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  631
gccuguaggc auaaauuggu a                     21


<210>  632
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  21
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  632
gccuguaggc auaaauuggu an                    22


<210>  633
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  20,21
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  633
gccuguaggc auaaauuggt an                    22


<210>  634
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  634
aacuguaggc auaaauuggu an                    22


<210>  635
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  635
ucguggugga cuucucucaa un                    22


<210>  636
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  636
aaguggugga cuucucucaa un                    22


<210>  637
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  20,21
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  637
ucguggugga cuucucucaa tn                    22


<210>  638
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  638
cgugguggac uucucucaau un                    22


<210>  639
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  639
aaugguggac uucucucaau un                    22


<210>  640
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  20,21
<223>  /mod_base = "2'-MOE nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  640
cgugguggac uucucucaat tn                    22


<210>  641
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  641
ggacuucucu caauuuucua an                    22


<210>  642
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  642
cgugguggac uucucucaau an                    22


<210>  643
<211>  22
<212>  DNA
<213>  artificial sequence

<220>  
<223>  HBV RNAi trigger sense strand

<220>  
<221>  modified base
<222>  9,10,11
<223>  /mod_base = "2'-deoxy-3'-fluoro nucleoside"

<220>  
<221>  modified base
<222>  1,2,3,4,5,6,7,8,12,13,14,15,16,17,18,19,20,21
<223>  /mod_base = "2'-O-Methyl nucleoside"

<220>  
<221>  modified base
<222>  22
<223>  /mod_base = "inverted abasic nucleotide"

<220>  
<221>  modified base
<222>  1,2,22
<223>  /mod_base = "phosphorothioate linked nucleoside"

<220>  
<221>  modified base
<222>  1
<223>  /mod_base = "NAG25 modified nucleoside"

<400>  643
ucguggugga cuucucucaa an                    22


<210>  644
<211>  26
<212>  PRT
<213>  Apis florea

<400>  644

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  645
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  645

Ala Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     

<210>  646
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  646

Cys Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  647
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  647

Phe Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  648
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  648

His Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  649
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  649

Ile Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  650
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  650

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  651
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle

<400>  651

Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  652
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  652

Val Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  653
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  653

Trp Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  654
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  654

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  655
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-form Apis florea melittin sequence

<400>  655

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  656
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  656

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Leu Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  657
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  657

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Trp Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  658
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  658

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Thr Lys Arg Lys Gln 
            20                  25     


<210>  659
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  659

Tyr Ile Gly Ala Ile Leu Asn Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  660
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  660

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  661
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  661

Leu Ile Gly Ala Ile Leu Ser Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  662
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  662

Leu Ile Gly Ala Ile Leu Arg Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  663
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  663

Leu Ile Gly Ala Ile Leu His Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  664
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  664

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  665
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  665

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Leu Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  666
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  666

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Leu Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  667
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  667

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Cys Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  668
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  668

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Cys Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  669
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  669

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Ala Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  670
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  670

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  671
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  671

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Lys Arg Lys Gln 
            20                  25     


<210>  672
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  672

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Ala Arg Lys Gln 
            20                  25     


<210>  673
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  673

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Ala Lys Gln 
            20                  25     


<210>  674
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  674

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Ala Gln 
            20                  25     


<210>  675
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  675

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Cys 
            20                  25     


<210>  676
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  676

Leu Leu Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  677
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  677

Leu Ile Gly Ala Leu Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  678
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  678

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Lys Arg Lys Gln 
            20                  25     


<210>  679
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  679

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Ala Arg Lys Gln 
            20                  25     


<210>  680
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  680

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  681
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  681

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Cys Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  682
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  682

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Gly Leu 
1               5                   10                  15      

Ile Gly Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  683
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  683

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ala Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  684
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  684

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Ala Arg Lys Gln 
            20                  25     


<210>  685
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  685

Tyr Ile Ala Ala Ile Leu Lys Val Leu Ala Ala Ala Leu Ala Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  686
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  686

Leu Leu Gly Ala Leu Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  687
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<220>
<221>  misc_feature
<222>  2, 5, 17, 20
<223>  Xaa is Nle

<400>  687

Leu Xaa Gly Ala Xaa Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Xaa Ser Trp Xaa Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  688
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  688

Leu Val Gly Ala Val Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Val Ser Trp Val Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  689
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  689

Gly Leu Gly Ala Leu Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  690
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  2, 5, 17, 20
<223>  Xaa is Nle

<400>  690

Gly Xaa Gly Ala Xaa Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Xaa Ser Trp Xaa Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  691
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  691

Cys Glu Asp Asp Leu Leu Leu Gly Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  692
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  692

Cys Leu Val Val Leu Ile Val Val Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  693
<211>  26
<212>  PRT
<213>  Apis mellifera

<400>  693

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25    


<210>  694
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  694

Cys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  695
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Nle

<400>  695

Cys Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  696
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  696

Gly Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  697
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  697

Leu Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  698
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  698

Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  699
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  699

Lys Leu Lys Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  700
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  700

Cys Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  701
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Nle

<400>  701

Cys Lys Leu Lys Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  702
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  702

Gly Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  703
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  D-form Melittin-like peptide

<400>  703

Cys Pro Ala Asn Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  704
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  704

Asp Glu Pro Leu Arg Ala Ile Gly Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  705
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  705

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  706
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  706

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  707
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle

<400>  707

Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  708
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  708

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Lys Leu Lys Cys 
            20                  25                  30


<210>  709
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  709

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Pro Leu Gly Ile Ala Gly 
            20                  25                  30

Gln Cys 


<210>  710
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  710

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Lys Lys Lys Lys Lys 
            20                  25                  30


<210>  711
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  711

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Gly Phe Lys Gly Cys 
            20                  25                  30


<210>  712
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  712

Cys Phe Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25                  30


<210>  713
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  713

Phe Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu Ile 
1               5                   10                  15      

Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  714
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  714

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys 
            20


<210>  715
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  715

Leu Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys 
            20


<210>  716
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  716

Leu Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Gly Glu 
            20


<210>  717
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  717

Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro Leu Gly Thr 
1               5                   10                  15      

Ala Leu Val Lys Leu Ile Ala Gly Ile Leu 
            20                  25


<210>  718
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  718

Lys Leu Lys Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro 
1               5                   10                  15      

Leu Gly Thr Ala Leu Val Lys Leu Ile Ala Gly Ile Leu 
            20                  25


<210>  719
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  719

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ser Arg Lys Lys Arg Gln Gln 
            20                  25


<210>  720
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  720

Gly Ile Gly Ala Arg Leu Lys Val Leu Thr Thr Gly Leu Pro Arg Ile 
1               5                   10                  15      

Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  721
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  721

Gly Ile Gly Ala Ile Leu Lys Val Leu Ser Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Glu 
            20                  25


<210>  722
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  722

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Gly Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  723
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  723

Gly Ile Gly Ala Val Leu Lys Val Leu Ala Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  724
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  724

Gly Ile Gly Ala Val Leu Lys Val Leu Ser Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  725
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  725

Gly Ile Gly Ala Ile Leu Arg Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  726
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  726

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Lys Gln 
            20                  25


<210>  727
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  727

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Lys Lys Lys Gln Gln 
            20                  25


<210>  728
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  728

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Gly Ser Lys Lys Lys Lys 
            20                  25                  30


<210>  729
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  729

Lys Lys Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro 
1               5                   10                  15      

Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  730
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  730

Gly Ile Gly Ala Ile Leu Glu Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  731
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  731

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg 
            20


<210>  732
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  732

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg 
            20


<210>  733
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  733

Cys Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  734
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  734

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Gly 
            20                  25


<210>  735
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  735

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys 
            20                  25


<210>  736
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  736

Gln Gln Lys Lys Lys Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys 
            20                  25


<210>  737
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  737

Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro Leu Gly Thr 
1               5                   10                  15      

Ala Leu Val Lys Leu Ile Ala Gly Ile Gly 
            20                  25


<210>  738
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  738

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Ala Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys
            20                  25


<210>  739
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  D-form Melittin-like peptide

<400>  739

Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro Leu Gly Thr 
1               5                   10                  15      

Ala Leu Val Lys Leu Ile Ala Gly Ile Gly
            20                  25


<210>  740
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  740
gccggacctg catgacta                         18


<210>  741
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  741
ggtacagcaa caggagggat acata                 25


<210>  742
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus probe

<400>  742
ctgctcaagg aacctc                           16


<210>  743
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  HCR gene PCR primer

<400>  743
catgccacct ccaacatcca ctc                   23


<210>  744
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  HCR gene PCR primer

<400>  744
ggcatagcca cttactgacg actc                  24


<210>  745
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  HCR gene probe

<400>  745
ttgtcctggc gtggtttagg tagtgtga              28


<210>  746
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  746
gccggacctg catgacta                         18


<210>  747
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  747
ggtacagcaa caggagggat acata                 25


<210>  748
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus probe

<400>  748
ctgctcaagg aacctc                           16


<210>  749
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PNA standard

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  749
cuguaggcau aaauugguat                       20


<210>  750
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PNA standard

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  750
taccaauuua ugccuacagt t                     21


<210>  751
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PNA standard

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  751
accucugccu aaucaucuat                       20


<210>  752
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PNA standard

<220>  
<221>  modified base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  752
tagaugauua ggcagaggut t                     21


<210>  753
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Peptide nucleic acid probe

<400>  753
ctgtaggcat aaatt                            15


<210>  754
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Peptide nucleic acid probe

<400>  754
acctctgcct aatca                            15


<210>  755
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  755
cgaggcaggt cccctagaag                       20


<210>  756
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  756
tgcgacgcgg ygattg                           16


<210>  757
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus probe

<400>  757
agaactccct cgcctcgcag acg                   23


<210>  758
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  758
ccgtctgtgc cttctcatct g                     21


<210>  759
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus PCR primer

<400>  759
agtccaagag tyctcttatg yaagacctt             29


<210>  760
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hepatitis B virus probe

<400>  760
ccgtgtgcac ttcgcttcac ctctgc                26


<210>  761
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Firefly luciferase siRNA strand

<220>  
<221>  modified base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  761
uaucuuacgc ugaguacuuc gat                   23


<210>  762
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Firefly luciferase siRNA strand

<220>  
<221>  modified base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  762
ucgaaguacu cagcguaagt t                     21


<210>  763
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse GADPH PCR primer

<400>  763
gcccctatcc tatcaacact tccgg                 25


<210>  764
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse GADPH PCR primer

<400>  764
ttcgtctgcg aggcgaggga                       20


<210>  765
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse GADPH PCR primer

<400>  765
tctggaaagc tgtggcgtg                        19


<210>  766
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse GADPH PCR primer

<400>  766
ccagtgagct tcccgttcag                       20

