                         SEQUENCE LISTING

<110>  PepMab B.V.
 
<120>  Humanized anti-CCR7 receptor antibodies

<130>  P6053240PCT

<150>  EP15180415.0
<151>  2015-08-10

<160>  81    

<170>  PatentIn version 3.3

<210>  1
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Pro Gly Leu Thr Phe Arg Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Phe Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ala Tyr Arg Tyr Asp Gly Thr Gly Asp Tyr Ser Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Pro Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  3
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Phe Thr Phe Ser Asp Tyr Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Phe Ala Phe Ser Ser Tyr Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Phe Ala Phe Ser Asn Tyr Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Leu Thr Phe Arg Asp Phe Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Phe Pro Phe Ser Asn Tyr Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Phe Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  11

Ile Ser Asp Gly Gly Ser His Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Ile Ser Asp Gly Gly Thr Tyr Pro 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Ile Ser Ser Gly Gly Phe Tyr Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Ile Ser Ser Gly Gly Ser Tyr Thr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  15

Ile Ser Asp Arg Gly Ser Phe Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Ile Ser Ser Gly Gly Ser His Thr 
1               5               


<210>  17
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Arg Arg Ala Gly Arg Tyr Asp Glu Arg Asp Ala Met Asp Tyr 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  18

Thr Arg Arg Ala Tyr Arg Tyr Asp Val Lys Asn Ser Met Asp Tyr 
1               5                   10                  15  


<210>  19
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  19

Val Arg Arg Ala Tyr Arg Tyr Asp Gly Thr Gly Asp Tyr Ser Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  20
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  20

Ala Arg Arg Glu Tyr Arg Tyr Ala Glu Asn Ala Met Asp Tyr 
1               5                   10                  


<210>  21
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Arg Arg Ala Tyr Arg Tyr Asp Gly Asp Asn Ala Met Asp Tyr 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  22

Ala Arg Arg Ala Tyr Arg Tyr Asp Glu Asp Ser Ala Met Asp Ser 
1               5                   10                  15  


<210>  23
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  23

Ala Arg Ala Thr Thr Val Val Gly Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  25
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Asp Ile Gly Asp Asn 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Asp Ile Gly Asn Asn 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  27

Gln Asp Ile Gly Pro Ser 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Asp Ile Gly Gly Ser 
1               5       


<210>  29
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  29

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  30
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  30

Gln Asp Ile Gly Ser Ser 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  31

Ala Thr Ser 
1           


<210>  32
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  32

Ser Ile Ser 
1           


<210>  33
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  33

Leu Val Ser 
1           


<210>  34
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Leu Gln Tyr Ala Ser Ser Pro Leu Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  36

Leu Gln Phe Ala Ser Ser Pro Leu Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  37

Leu Gln Tyr Ala Asn Ser Pro Leu Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  38

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  39

Leu Gln Tyr Ala Ser Ser Pro Pro Thr 
1               5                   


<210>  40
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser 
            20                  25  


<210>  41
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  43
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Val Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  44
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Thr 
    


<210>  45
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  45

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Val Arg Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  46
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  46

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Ala Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  47
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  47

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ser Tyr Tyr Cys 
        35              


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  51
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  51

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  52
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  52

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  54
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  55
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  55

Asn Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  56
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  56

Asn Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  57
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  57

Asn Leu Asp Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  58
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  60

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  61
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VH1 domain

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Leu Thr Phe Arg Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Val Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Phe Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ala Tyr Arg Tyr Asp Gly Thr Gly Asp Tyr Ser Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VH2 domain

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Leu Thr Phe Arg Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Phe Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ala Tyr Arg Tyr Asp Gly Thr Gly Asp Tyr Ser Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  63
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VH3 domain

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Thr Phe Arg Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Phe Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ser Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ala Tyr Arg Tyr Asp Gly Thr Gly Asp Tyr Ser Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VK1 domain

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Pro Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  65
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VK2 domain

<400>  65

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Pro Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized VK3 domain

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Pro Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Asp Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Val Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Asn Ile Ile Tyr Tyr Pro Asp Asn Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Ser Thr Tyr Gly Gly Phe Asp His Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  68
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Met His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ala Asn Arg Gly Tyr Ser Tyr Asp Thr Leu Pro Ser Phe Val 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  69
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Ala Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ser Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp His Tyr Thr Asp Ser Ser Gly Trp Tyr Glu Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  70
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Asn Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Asn Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  74
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  75
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  76
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  SYM1899: synthetic sulfated peptide corresponding to amino acids 
       19-49 of human CCR7


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  SULFATATION

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  SULFATATION

<400>  76

Glu Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg Asn Lys 
            20                  25                  30          


<210>  77
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain signal peptide

<400>  77

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  78
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  light chain signal peptide

<400>  78

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  79
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  80
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic heavy chain constant region of the human allotype G1m 
       (17,1) with a E333A substitution

<400>  80

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  81
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HVR-H3 of control antibody 11-x

<400>  81

Ala Arg Ala Thr Thr Val Val Gly Thr Asp Phe Asp Tyr 
1               5                   10              


