                         SEQUENCE LISTING

<110>  Pieris AG
 
<120>  Novel fusion polypeptide specific for LAG-3 and PD-1

<130>  PIE15467PCT

<150>  EP 15 180 116.4
<151>  2015-08-07

<150>  EP 16 150 707.4
<151>  2016-01-11

<160>  192

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human tear lipocalin

<400>  1

His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn 
            20                  25                  30          


Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn 
        35                  40                  45              


Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val 
    50                  55                  60                  


Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp 
65                  70                  75                  80  


Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His 
                85                  90                  95      


Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly 
            100                 105                 110         


Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu 
        115                 120                 125             


Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile 
    130                 135                 140                 


Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
145                 150                 155             


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  3
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   heavy chain of PD-1 benchmark antibody 1

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly 
        435                 


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of PD-1 benchmark antibody 1

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
    450                 455                 460                 


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Ser Asp Cys Phe Trp 
465                 470                 475                 480 


Ile Asp Asp Val Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
                485                 490                 495     


Gly Asn Leu Glu Ala Lys Val Thr Met Asp Ile Phe Gly Phe Trp Gln 
            500                 505                 510         


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
        515                 520                 525             


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
    530                 535                 540                 


Asp His Tyr Ile Phe Tyr Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val 
545                 550                 555                 560 


Pro Gly Val Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
                565                 570                 575     


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
            580                 585                 590         


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
        595                 600                 605     


<210>  6
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  6

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
                165                 170                 175     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys 
            180                 185                 190         


Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln 
        195                 200                 205             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly 
    210                 215                 220                 


Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg 
                245                 250                 255     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        275                 280                 285             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    290                 295                 300                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
305                 310                 315                 320 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                325                 330                 335     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            340                 345                 350         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        355                 360                 365             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    370                 375                 380                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
385                 390                 395                 400 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                405                 410                 415     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            420                 425                 430         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        435                 440                 445             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    450                 455                 460                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
465                 470                 475                 480 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                485                 490                 495     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            500                 505                 510         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        515                 520                 525             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    530                 535                 540                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
545                 550                 555                 560 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                565                 570                 575     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            580                 585                 590         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        595                 600                 605             


<210>  7
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly 
225                 230                 235                 240 


Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile 
                245                 250                 255     


Asp Asp Val Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly 
            260                 265                 270         


Asn Leu Glu Ala Lys Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu 
        275                 280                 285             


Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala 
    290                 295                 300                 


Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp 
305                 310                 315                 320 


His Tyr Ile Phe Tyr Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro 
                325                 330                 335     


Gly Val Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu 
            340                 345                 350         


Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser 
        355                 360                 365             


Ile Leu Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
    370                 375                 380     


<210>  8
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  8

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
                165                 170                 175     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            180                 185                 190         


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
    210                 215                 220                 


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys 
            260                 265                 270         


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    290                 295                 300                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
305                 310                 315                 320 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                325                 330                 335     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            340                 345                 350         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        355                 360                 365             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    370                 375                 380             


<210>  9
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Pro 
    450                 455                 460                 


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Ser Gly Glu Asp Pro Glu 
465                 470                 475                 480 


Met Met Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
                485                 490                 495     


Gly Asn Leu Glu Ala Arg Val Thr Val Leu Ile Asp Gly Arg Cys Gln 
            500                 505                 510         


Glu Val Lys Asn Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
        515                 520                 525             


Glu Asp Gly Gly Lys His Val Asp Tyr Ile Ile Arg Ser His Val Lys 
    530                 535                 540                 


Asp His Tyr Ile Phe Tyr Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly 
545                 550                 555                 560 


Arg Met Val Ala Leu Val Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala 
                565                 570                 575     


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
            580                 585                 590         


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly 
        595                 600                 605     


<210>  10
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  10

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
                165                 170                 175     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys 
            180                 185                 190         


Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln 
        195                 200                 205             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly 
    210                 215                 220                 


Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg 
                245                 250                 255     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        275                 280                 285             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    290                 295                 300                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
305                 310                 315                 320 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                325                 330                 335     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            340                 345                 350         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        355                 360                 365             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    370                 375                 380                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
385                 390                 395                 400 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                405                 410                 415     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            420                 425                 430         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        435                 440                 445             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    450                 455                 460                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
465                 470                 475                 480 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                485                 490                 495     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            500                 505                 510         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        515                 520                 525             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    530                 535                 540                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
545                 550                 555                 560 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                565                 570                 575     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            580                 585                 590         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        595                 600                 605             


<210>  11
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly 
225                 230                 235                 240 


Thr Trp Tyr Leu Lys Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met 
                245                 250                 255     


Met Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly 
            260                 265                 270         


Asn Leu Glu Ala Arg Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu 
        275                 280                 285             


Val Lys Asn Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu 
    290                 295                 300                 


Asp Gly Gly Lys His Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp 
305                 310                 315                 320 


His Tyr Ile Phe Tyr Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg 
                325                 330                 335     


Met Val Ala Leu Val Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu 
            340                 345                 350         


Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser 
        355                 360                 365             


Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly 
    370                 375                 380     


<210>  12
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  12

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
                165                 170                 175     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            180                 185                 190         


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
    210                 215                 220                 


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys 
            260                 265                 270         


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    290                 295                 300                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
305                 310                 315                 320 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                325                 330                 335     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            340                 345                 350         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        355                 360                 365             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    370                 375                 380             


<210>  13
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  13

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Glu Glu Trp Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Phe Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  14
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  14

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Asn 
        35                  40                  45              


Val Thr Ala Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly His Gly Thr Pro Ala Arg Thr Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  15
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  15

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Val Cys Leu Tyr Asp Val Pro Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Gln Ile Trp Gly Glu Leu Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Tyr Cys Val Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  16
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  16

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Glu Thr Cys Trp Trp Tyr Val Asp His Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Leu Trp Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Gln Gly Trp Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  17
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  17

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  18
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  18

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  19
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  19

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Glu Glu Trp Ser Ala 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asp Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Phe Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Gly Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  20
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  20

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Glu Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Glu Gly Phe Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  21
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  21

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Glu Glu Trp Ser Ala 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Glu 
        35                  40                  45              


Ala Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Phe Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  22
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  22

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Val Asp Glu Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Phe Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  23
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  23

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Leu Trp Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Ser 
        35                  40                  45              


Val Thr Ala Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Tyr Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  24
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  24

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Ala Glu Asp Pro Glu Leu Val Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Ser 
        35                  40                  45              


Val Thr Ala Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly His Gly Thr Pro Ala Arg Thr Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  25
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  25

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Asp Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Ser 
        35                  40                  45              


Val Thr Ala Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  26
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  26

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Glu Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Ser 
        35                  40                  45              


Val Thr Ala Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly His Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  27
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  27

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  28
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  28

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Val Cys Leu Asn Asp Tyr Pro Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Gln Ile Trp Gly Glu Pro Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Tyr Cys Thr Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  29
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  29
caggtgcagc tggtggaatc tggcggcgga gtggtgcagc ctggcagatc tctgagactg       60

gactgcaagg cctccggcat caccttctcc aactccggca tgcactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtggccgtg atttggtacg acggctccaa gcggtactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgttt      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc caccaacgac      300

gactactggg gccagggcac actcgtgacc gtgtcctctg cttccaccaa gggcccctcc      360

gtgtttcctc tggccccttg ctccagatcc acctccgagt ctaccgccgc tctgggctgc      420

ctcgtgaagg actacttccc cgagcccgtg acagtgtctt ggaactctgg cgccctgacc      480

tccggcgtgc acacctttcc agctgtgctg cagtcctccg gcctgtactc cctgtcctcc      540

gtcgtgactg tgccctccag ctctctgggc accaagacct acacctgtaa cgtggaccac      600

aagccctcca acaccaaggt ggacaagaga gtggaatcta agtacggccc tccctgcccc      660

ccttgtcctg cccctgaatt tctgggcgga ccttccgtgt tcctgttccc cccaaagcct      720

aaggacaccc tgatgatctc ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc      780

caggaagatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      840

aagaccaagc ctagagagga acagttcaac tccacctacc gggtggtgtc cgtgctgacc      900

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc      960

ctgcccagct ccatcgaaaa gaccatctcc aaggccaagg gccagccccg ggaaccccag     1020

gtgtacacac tgcctccaag ccaggaagag atgaccaaga accaggtgtc cctgacctgt     1080

ctcgtgaaag gcttctaccc ctccgatatc gccgtggaat gggagtccaa cggccagcct     1140

gagaacaact ataagaccac cccccctgtg ctggactccg acggcagctt cttcctgtac     1200

tctcgcctga ccgtggacaa gtcccggtgg caggaaggca acgtgttctc ctgctccgtg     1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtccctgtc tctgggaggt     1320

ggcggaggat ctggcggagg cggttctggc ggcggtggat ctgcttccga cgaagagatc     1380

caggacgtgt ccggcacctg gtatctgaag gccatgaccg tggactccga ctgcttctgg     1440

atcgacgatg tgtccgtgac ccccatgacc ctgaccaccc tggaaggcgg caacctggaa     1500

gccaaagtga caatggatat cttcggcttc tggcaggaag tgaaggccgt gctggaaaag     1560

accgacgagc ccggcaagta caccgccgat ggcggcaagc acgtggccta catcatccgg     1620

tcccacgtga aggaccacta catcttctac tccgagggcg agtgcgccgg ctatcctgtg     1680

cctggcgtgt ggctcgtggg ccgggatcct aagaacaatc tggaagccct ggaagatttc     1740

gagaaggccg ctggcgctcg gggcctgtct acagagtcta tcctgatccc ccggcagtcc     1800

gagacatcct cccctggc                                                   1818


<210>  30
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  30
gcctctgacg aagagatcca ggacgtgtcc ggcacctggt atctgaaggc catgaccgtg       60

gactccgact gcttctggat cgacgatgtg tccgtgaccc ccatgaccct gaccaccctg      120

gaaggcggca acctggaagc caaagtgaca atggatatct tcggcttctg gcaggaagtg      180

aaggccgtgc tggaaaagac cgacgagccc ggcaagtaca ccgccgatgg cggcaagcac      240

gtggcctaca tcatccggtc ccacgtgaag gaccactaca tcttctactc cgagggcgag      300

tgcgccggct atcctgtgcc tggcgtgtgg ctcgtgggcc gggatcctaa gaacaatctg      360

gaagccctgg aagatttcga gaaggccgct ggcgctcggg gcctgtctac agagtctatc      420

ctgatccccc ggcagtccga gacatcctcc cctggatctg atggcggcgg aggatctggc      480

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tggaatctgg cggcggagtg      540

gtgcagcctg gcagatctct gagactggac tgcaaggcct ccggcatcac cttctccaac      600

tccggcatgc actgggtgcg acaggcccct ggaaagggcc tggaatgggt ggccgtgatt      660

tggtacgacg gctccaagcg gtactacgcc gactctgtga agggccggtt caccatctcc      720

cgggacaact ccaagaacac cctgtttctg cagatgaact ccctgcgggc cgaggacacc      780

gccgtgtact actgtgccac caacgacgac tactggggcc agggcacact cgtgaccgtg      840

tcctctgctt ccaccaaggg cccctccgtg tttcctctgg ccccttgctc cagatccacc      900

tccgagtcta ccgccgctct gggctgcctc gtgaaggact acttccccga gcccgtgaca      960

gtgtcttgga actctggcgc cctgacctcc ggcgtgcaca cctttccagc tgtgctgcag     1020

tcctccggcc tgtactccct gtcctccgtc gtgactgtgc cctccagctc tctgggcacc     1080

aagacctaca cctgtaacgt ggaccacaag ccctccaaca ccaaggtgga caagagagtg     1140

gaatctaagt acggccctcc ctgcccccct tgtcctgccc ctgaatttct gggcggacct     1200

tccgtgttcc tgttcccccc aaagcctaag gacaccctga tgatctcccg gacccccgaa     1260

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac     1320

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gttcaactcc     1380

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag     1440

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgaaaagac catctccaag     1500

gccaagggcc agccccggga accccaggtg tacacactgc ctccaagcca ggaagagatg     1560

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctacccctc cgatatcgcc     1620

gtggaatggg agtccaacgg ccagcctgag aacaactata agaccacccc ccctgtgctg     1680

gactccgacg gcagcttctt cctgtactct cgcctgaccg tggacaagtc ccggtggcag     1740

gaaggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1800

aagtccctgt ccctgtctct ggga                                            1824


<210>  31
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bisecific fusion polypeptide

<400>  31
gagatcgtgc tgacccagtc tcctgccacc ctgtctctga gccctggcga gagagctacc       60

ctgtcctgca gagcctccca gtccgtgtcc tcttacctgg cctggtatca gcagaagccc      120

ggccaggctc cccggctgct gatctacgat gcctccaata gagccaccgg catccctgcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag tcctccaact ggccccggac ctttggccag      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gcggaggcgg aggatctggt      660

ggtggtggat ctggcggcgg aggctctgcc tctgacgaag agatccagga cgtgtccggc      720

acctggtatc tgaaggccat gaccgtggac tccgactgct tctggatcga cgatgtgtcc      780

gtgaccccca tgaccctgac caccctggaa ggcggcaacc tggaagccaa agtgacaatg      840

gatatcttcg gcttctggca ggaagtgaag gccgtgctgg aaaagaccga cgagcccggc      900

aagtacaccg ccgatggcgg caagcacgtg gcctacatca tccggtccca cgtgaaggac      960

cactacatct tctactccga gggcgagtgt gccggctacc ctgtgcctgg cgtgtggctc     1020

gtgggcaggg accctaagaa caatctggaa gccctggaag atttcgagaa ggccgctggc     1080

gctcggggcc tgtctacaga gtctatcctg atcccccggc agtccgagac atcctcccct     1140

ggc                                                                   1143


<210>  32
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  32
gcctctgacg aagagatcca ggacgtgtcc ggcacctggt atctgaaggc catgaccgtg       60

gactccgact gcttctggat cgacgatgtg tccgtgaccc ccatgaccct gaccaccctg      120

gaaggcggca acctggaagc caaagtgaca atggatatct tcggcttctg gcaggaagtg      180

aaggccgtgc tggaaaagac cgacgagccc ggcaagtaca ccgccgatgg cggcaagcac      240

gtggcctaca tcatccggtc ccacgtgaag gaccactaca tcttctactc cgagggcgag      300

tgcgccggct atcctgtgcc tggcgtgtgg ctcgtgggcc gggatcctaa gaacaatctg      360

gaagccctgg aagatttcga gaaggccgct ggcgctcggg gcctgtctac agagtctatc      420

ctgatccccc ggcagtccga gacatcctcc cctggatctg atggcggcgg aggatctggc      480

ggaggtggaa gcggaggggg aggatctgag atcgtgctga cccagtctcc tgccaccctg      540

tctctgagcc ctggcgagag agctaccctg tcctgcagag cctcccagtc cgtgtcctct      600

tacctggcct ggtatcagca gaagcccggc caggctcccc ggctgctgat ctacgatgcc      660

tccaatagag ccaccggcat ccctgccaga ttctccggct ctggctctgg caccgacttt      720

accctgacca tctccagcct ggaacccgag gacttcgccg tgtactactg ccagcagtcc      780

tccaactggc cccggacctt tggccagggc accaaggtgg aaatcaagcg gaccgtggcc      840

gctccctccg tgttcatctt cccaccttcc gacgagcagc tgaagtccgg caccgcttct      900

gtcgtgtgcc tgctgaacaa cttctacccc cgcgaggcca aggtgcagtg gaaggtggac      960

aacgccctgc agtccggcaa ctcccaggaa tccgtgaccg agcaggactc caaggacagc     1020

acctactccc tgtcctccac cctgaccctg tccaaggccg actacgagaa gcacaaggtg     1080

tacgcctgcg aagtgaccca ccagggcctg tctagccccg tgaccaagtc tttcaaccgg     1140

ggcgagtgc                                                             1149


<210>  33
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  33
caggtgcagc tggtggaatc tggcggcgga gtggtgcagc ctggcagatc tctgagactg       60

gactgcaagg cctccggcat caccttctcc aactccggca tgcactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtggccgtg atttggtacg acggctccaa gcggtactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgttt      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc caccaacgac      300

gactactggg gccagggcac actcgtgacc gtgtcctctg cttccaccaa gggcccctcc      360

gtgtttcctc tggccccttg ctccagatcc acctccgagt ctaccgccgc tctgggctgc      420

ctcgtgaagg actacttccc cgagcccgtg acagtgtctt ggaactctgg cgccctgacc      480

tccggcgtgc acacctttcc agctgtgctg cagtcctccg gcctgtactc cctgtcctcc      540

gtcgtgactg tgccctccag ctctctgggc accaagacct acacctgtaa cgtggaccac      600

aagccctcca acaccaaggt ggacaagaga gtggaatcta agtacggccc tccctgcccc      660

ccttgtcctg cccctgaatt tctgggcgga ccttccgtgt tcctgttccc cccaaagcct      720

aaggacaccc tgatgatctc ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc      780

caggaagatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      840

aagaccaagc ctagagagga acagttcaac tccacctacc gggtggtgtc cgtgctgacc      900

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc      960

ctgcccagct ccatcgaaaa gaccatctcc aaggccaagg gccagccccg ggaaccccag     1020

gtgtacacac tgcctccaag ccaggaagag atgaccaaga accaggtgtc cctgacctgt     1080

ctcgtgaaag gcttctaccc ctccgatatc gccgtggaat gggagtccaa cggccagcct     1140

gagaacaact ataagaccac cccccctgtg ctggactccg acggcagctt cttcctgtac     1200

tctcgcctga ccgtggacaa gtcccggtgg caggaaggca acgtgttctc ctgctccgtg     1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtccctgtc tctgggaggt     1320

ggcggaggat ctggcggagg cggttctggc ggcggtggat ctgcttccga cgaagagatc     1380

caggacgtgc ccggcacctg gtatctgaag gccatgaccg tgtccggcga ggaccccgag     1440

atgatgctgg aatccgtgac ccccatgacc ctgaccaccc tggaaggcgg caacctggaa     1500

gccagagtga ccgtgctgat cgacggccgg tgccaggaag tgaagaacgt gctggaaaag     1560

accgacgagc ccggcaagta caccgaggat ggcggaaagc acgtggacta catcatccgg     1620

tcccacgtga aggaccacta catcttctac ttcgagggcg agggccaggg cacccctgga     1680

agaatggtgg ctctcgtggg ccgggacccc accaacaatc tggaagctct ggaagatttc     1740

gagaaggccg ctggcgctcg gggcctgtct acagagtcta tcctgatccc ccggcagtcc     1800

gagacatgct cccctggc                                                   1818


<210>  34
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  34
gcctctgacg aagagatcca ggatgtgccc ggcacctggt atctgaaggc catgaccgtg       60

tccggcgagg accccgagat gatgctggaa tccgtgaccc ccatgaccct gaccaccctg      120

gaaggcggca acctggaagc cagagtgacc gtgctgatcg acggccggtg ccaggaagtg      180

aagaacgtgc tggaaaagac cgacgagccc ggcaagtaca ccgaggatgg cggaaagcac      240

gtggactaca tcatccggtc ccacgtgaag gaccactaca tcttctactt cgagggcgag      300

ggccagggca cccctggaag aatggtggct ctcgtgggcc gggaccccac caacaatctg      360

gaagctctgg aagatttcga gaaggccgct ggcgctcggg gcctgtctac agagtctatc      420

ctgatccccc ggcagtccga gacatgctcc cctggatctg atggcggcgg aggatctggc      480

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tggaatctgg cggcggagtg      540

gtgcagcctg gcagatctct gagactggac tgcaaggcct ccggcatcac cttctccaac      600

tccggcatgc actgggtgcg acaggcccct ggaaagggcc tggaatgggt ggccgtgatt      660

tggtacgacg gctccaagcg gtactacgcc gactctgtga agggccggtt caccatctcc      720

cgggacaact ccaagaacac cctgtttctg cagatgaact ccctgcgggc cgaggacacc      780

gccgtgtact actgtgccac caacgacgac tactggggcc agggcacact cgtgaccgtg      840

tcctctgctt ccaccaaggg cccctccgtg tttcctctgg ccccttgctc cagatccacc      900

tccgagtcta ccgccgctct gggctgcctc gtgaaggact acttccccga gcccgtgaca      960

gtgtcttgga actctggcgc cctgacctcc ggcgtgcaca cctttccagc tgtgctgcag     1020

tcctccggcc tgtactccct gtcctccgtc gtgactgtgc cctccagctc tctgggcacc     1080

aagacctaca cctgtaacgt ggaccacaag ccctccaaca ccaaggtgga caagagagtg     1140

gaatctaagt acggccctcc ctgcccccct tgtcctgccc ctgaatttct gggcggacct     1200

tccgtgttcc tgttcccccc aaagcctaag gacaccctga tgatctcccg gacccccgaa     1260

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac     1320

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gttcaactcc     1380

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag     1440

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgaaaagac catctccaag     1500

gccaagggcc agccccggga accccaggtg tacacactgc ctccaagcca ggaagagatg     1560

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctacccctc cgatatcgcc     1620

gtggaatggg agtccaacgg ccagcctgag aacaactata agaccacccc ccctgtgctg     1680

gactccgacg gcagcttctt cctgtactct cgcctgaccg tggacaagtc ccggtggcag     1740

gaaggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1800

aagtccctgt ccctgtctct ggga                                            1824


<210>  35
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  35
gagatcgtgc tgacccagtc tcctgccacc ctgtctctga gccctggcga gagagctacc       60

ctgtcctgca gagcctccca gtccgtgtcc tcttacctgg cctggtatca gcagaagccc      120

ggccaggctc cccggctgct gatctacgat gcctccaata gagccaccgg catccctgcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag tcctccaact ggccccggac ctttggccag      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gcggaggcgg aggatctggt      660

ggtggtggat ctggcggcgg aggctctgcc tctgacgaag agatccagga tgtgcccggc      720

acctggtatc tgaaggccat gaccgtgtcc ggcgaggacc ccgagatgat gctggaatcc      780

gtgaccccca tgaccctgac caccctggaa ggcggcaacc tggaagccag agtgaccgtg      840

ctgatcgacg gccggtgcca ggaagtgaag aacgtgctgg aaaagaccga cgagcccggc      900

aagtacaccg aggatggcgg aaagcacgtg gactacatca tccggtccca cgtgaaggac      960

cactacatct tctacttcga gggcgagggc cagggcaccc ctggaagaat ggtggctctc     1020

gtgggccggg accccaccaa caatctggaa gctctggaag atttcgagaa ggccgctggc     1080

gctcggggcc tgtctacaga gtctatcctg atcccccggc agtccgagac atgctcccct     1140

ggc                                                                   1143


<210>  36
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  36
gcctctgacg aagagatcca ggatgtgccc ggcacctggt atctgaaggc catgaccgtg       60

tccggcgagg accccgagat gatgctggaa tccgtgaccc ccatgaccct gaccaccctg      120

gaaggcggca acctggaagc cagagtgacc gtgctgatcg acggccggtg ccaggaagtg      180

aagaacgtgc tggaaaagac cgacgagccc ggcaagtaca ccgaggatgg cggaaagcac      240

gtggactaca tcatccggtc ccacgtgaag gaccactaca tcttctactt cgagggcgag      300

ggccagggca cccctggaag aatggtggct ctcgtgggcc gggaccccac caacaatctg      360

gaagctctgg aagatttcga gaaggccgct ggcgctcggg gcctgtctac agagtctatc      420

ctgatccccc ggcagtccga gacatgctcc cctggatctg atggcggcgg aggatctggc      480

ggaggtggaa gcggaggggg aggatctgag atcgtgctga cccagtctcc tgccaccctg      540

tctctgagcc ctggcgagag agctaccctg tcctgcagag cctcccagtc cgtgtcctct      600

tacctggcct ggtatcagca gaagcccggc caggctcccc ggctgctgat ctacgatgcc      660

tccaatagag ccaccggcat ccctgccaga ttctccggct ctggctctgg caccgacttt      720

accctgacca tctccagcct ggaacccgag gacttcgccg tgtactactg ccagcagtcc      780

tccaactggc cccggacctt tggccagggc accaaggtgg aaatcaagcg gaccgtggcc      840

gctccctccg tgttcatctt cccaccttcc gacgagcagc tgaagtccgg caccgcttct      900

gtcgtgtgcc tgctgaacaa cttctacccc cgcgaggcca aggtgcagtg gaaggtggac      960

aacgccctgc agtccggcaa ctcccaggaa tccgtgaccg agcaggactc caaggacagc     1020

acctactccc tgtcctccac cctgaccctg tccaaggccg actacgagaa gcacaaggtg     1080

tacgcctgcg aagtgaccca ccagggcctg tctagccccg tgaccaagtc tttcaaccgg     1140

ggcgagtgc                                                             1149


<210>  37
<211>  456
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein encoding the lipocalin mutein of SEQ ID NO: 17

<400>  37
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  38
<211>  456
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein encoding the lipocalin mutein of SEQ ID NO: 27

<400>  38
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

tcgggggaag atcctgagat gatgctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tcgtgtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaatgtgc tcgagaagac agatgaaccg ggtaaataca cggaggatgg cggcaaacat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

gggcagggca cgccgggtcg catggtggct ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  39
<211>  1317
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain of benchmark antibody 1 (SEQ ID NO: 3)

<400>  39
caggtgcagc tggtggaatc tggcggcgga gtggtgcagc ctggcagatc tctgagactg       60

gactgcaagg cctccggcat caccttctcc aactccggca tgcactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtggccgtg atttggtacg acggctccaa gcggtactac      180

gccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgttt      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc caccaacgac      300

gactactggg gccagggcac actcgtgacc gtgtcctctg cttccaccaa gggcccctcc      360

gtgtttcctc tggccccttg ctccagatcc acctccgagt ctaccgccgc tctgggctgc      420

ctcgtgaagg actacttccc cgagcccgtg acagtgtctt ggaactctgg cgccctgacc      480

tccggcgtgc acacctttcc agctgtgctg cagtcctccg gcctgtactc cctgtcctcc      540

gtcgtgactg tgccctccag ctctctgggc accaagacct acacctgtaa cgtggaccac      600

aagccctcca acaccaaggt ggacaagaga gtggaatcta agtacggccc tccctgcccc      660

ccttgtcctg cccctgaatt tctgggcgga ccttccgtgt tcctgttccc cccaaagcct      720

aaggacaccc tgatgatctc ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc      780

caggaagatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      840

aagaccaagc ctagagagga acagttcaac tccacctacc gggtggtgtc cgtgctgacc      900

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc      960

ctgcccagct ccatcgaaaa gaccatctcc aaggccaagg gccagccccg ggaaccccag     1020

gtgtacacac tgcctccaag ccaggaagag atgaccaaga accaggtgtc cctgacctgt     1080

ctcgtgaaag gcttctaccc ctccgatatc gccgtggaat gggagtccaa cggccagcct     1140

gagaacaact ataagaccac cccccctgtg ctggactccg acggcagctt cttcctgtac     1200

tctcgcctga ccgtggacaa gtcccggtgg caggaaggca acgtgttctc ctgctccgtg     1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtccctgtc tctggga        1317


<210>  40
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  light chain of benchmark antibody 1 (SEQ ID NO: 4)

<400>  40
gagatcgtgc tgacccagtc tcctgccacc ctgtctctga gccctggcga gagagctacc       60

ctgtcctgca gagcctccca gtccgtgtcc tcttacctgg cctggtatca gcagaagccc      120

ggccaggctc cccggctgct gatctacgat gcctccaata gagccaccgg catccctgcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag tcctccaact ggccccggac ctttggccag      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gc                         642


<210>  41
<211>  395
<212>  PRT
<213>  artificial

<220>
<223>  Fc lipocalin mutein

<400>  41

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp 
            260                 265                 270         


Val Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Lys Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys 
    290                 295                 300                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val 
            340                 345                 350         


Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
385                 390                 395 


<210>  42
<211>  395
<212>  PRT
<213>  artificial

<220>
<223>  Fc lipocalin mutein

<400>  42

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu 
            260                 265                 270         


Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Arg Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys 
    290                 295                 300                 


Asn Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val 
            340                 345                 350         


Ala Leu Val Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly 
385                 390                 395 


<210>  43
<211>  152
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein negative control

<400>  43

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Cys Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys His Gly Lys Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  44
<211>  1185
<212>  DNA
<213>  artificial

<220>
<223>  Fc lipocalin mutein encoding SEQ ID NO: 41

<400>  44
gaatctaagt acggccctcc ctgcccccct tgtcctgccc ctgaatttct gggcggacct       60

tccgtgttcc tgttcccccc aaagcctaag gacaccctga tgatctcccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gttcaactcc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgaaaagac catctccaag      360

gccaagggcc agccccggga accccaggtg tacacactgc ctccaagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctacccctc cgatatcgcc      480

gtggaatggg agtccaacgg ccagcctgag aacaactata agaccacccc ccctgtgctg      540

gactccgacg gcagcttctt cctgtactct cgcctgaccg tggacaagtc ccggtggcag      600

gaaggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ccctgtctct gggaggtggc ggaggatctg gcggaggcgg ttctggcggc      720

ggtggatctg cttccgacga agagatccag gacgtgtccg gcacctggta tctgaaggcc      780

atgaccgtgg actccgactg cttctggatc gacgatgtgt ccgtgacccc catgaccctg      840

accaccctgg aaggcggcaa cctggaagcc aaagtgacaa tggatatctt cggcttctgg      900

caggaagtga aggccgtgct ggaaaagacc gacgagcccg gcaagtacac cgccgatggc      960

ggcaagcacg tggcctacat catccggtcc cacgtgaagg accactacat cttctactcc     1020

gagggcgagt gcgccggcta tcctgtgcct ggcgtgtggc tcgtgggccg ggatcctaag     1080

aacaatctgg aagccctgga agatttcgag aaggccgctg gcgctcgggg cctgtctaca     1140

gagtctatcc tgatcccccg gcagtccgag acatcctccc ctggc                     1185


<210>  45
<211>  1185
<212>  DNA
<213>  artificial

<220>
<223>  Fc lipocalin mutein encoding SEQ ID NO: 42

<400>  45
gaatctaagt acggccctcc ctgcccccct tgtcctgccc ctgaatttct gggcggacct       60

tccgtgttcc tgttcccccc aaagcctaag gacaccctga tgatctcccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gttcaactcc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgaaaagac catctccaag      360

gccaagggcc agccccggga accccaggtg tacacactgc ctccaagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctacccctc cgatatcgcc      480

gtggaatggg agtccaacgg ccagcctgag aacaactata agaccacccc ccctgtgctg      540

gactccgacg gcagcttctt cctgtactct cgcctgaccg tggacaagtc ccggtggcag      600

gaaggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ccctgtctct gggaggtggc ggaggatctg gcggaggcgg ttctggcggc      720

ggtggatctg cttccgacga agagatccag gacgtgcccg gcacctggta tctgaaggcc      780

atgaccgtgt ccggcgagga ccccgagatg atgctggaat ccgtgacccc catgaccctg      840

accaccctgg aaggcggcaa cctggaagcc agagtgaccg tgctgatcga cggccggtgc      900

caggaagtga agaacgtgct ggaaaagacc gacgagcccg gcaagtacac cgaggatggc      960

ggaaagcacg tggactacat catccggtcc cacgtgaagg accactacat cttctacttc     1020

gagggcgagg gccagggcac ccctggaaga atggtggctc tcgtgggccg ggaccccacc     1080

aacaatctgg aagctctgga agatttcgag aaggccgctg gcgctcgggg cctgtctaca     1140

gagtctatcc tgatcccccg gcagtccgag acatgctccc ctggc                     1185


<210>  46
<211>  456
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein control encoding SEQ ID NO: 43

<400>  46
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacagggagt gccctgagat gaatctggaa tcggtgacac ccatgaccct cacgaccctg      120

gaagggggca acctggaagc caaggtcacc atgctgataa gtggccggag ccaggaggtg      180

aaggccgtcc tggagaaaac tgacgagccg ggaaaataca cggccgacgg gggcaagcac      240

gtggcataca tcatcaggtc gcacgtgaag gaccactaca tcttttactc tgagggcgag      300

tgccacggga agccggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  47
<211>  447
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain of PD-1 benchmark antibody 2

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  48
<211>  218
<212>  PRT
<213>  artificial

<220>
<223>  light chain of PD-1 benchmark antibody 2

<400>  48

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  49
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of LAG-3 benchmark antibody

<400>  49

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  50
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of LAG-3 benchmark antibody

<400>  50

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  51
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
    450                 455                 460                 


Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met 
465                 470                 475                 480 


Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val Thr Pro 
                485                 490                 495     


Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr 
            500                 505                 510         


Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu Glu Lys 
        515                 520                 525             


Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala 
    530                 535                 540                 


Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Ser Glu 
545                 550                 555                 560 


Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val Gly Arg 
                565                 570                 575     


Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala 
            580                 585                 590         


Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser 
        595                 600                 605             


Glu Thr Ser Ser Pro Gly 
    610                 


<210>  52
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  52

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Val 
                165                 170                 175     


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            180                 185                 190         


Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly 
    210                 215                 220                 


Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met 
            260                 265                 270         


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    290                 295                 300                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        355                 360                 365             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    370                 375                 380                 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            420                 425                 430         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        435                 440                 445             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    450                 455                 460                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                485                 490                 495     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            500                 505                 510         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        515                 520                 525             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    530                 535                 540                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
545                 550                 555                 560 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            580                 585                 590         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        595                 600                 605             


Ser Leu Ser Leu Gly Lys 
    610                 


<210>  53
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln 
225                 230                 235                 240 


Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Ser Asp 
                245                 250                 255     


Cys Phe Trp Ile Asp Asp Val Ser Val Thr Pro Met Thr Leu Thr Thr 
            260                 265                 270         


Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met Asp Ile Phe Gly 
        275                 280                 285             


Phe Trp Gln Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly 
    290                 295                 300                 


Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser 
305                 310                 315                 320 


His Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly Glu Cys Ala Gly 
                325                 330                 335     


Tyr Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp Pro Lys Asn Asn 
            340                 345                 350         


Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu 
        355                 360                 365             


Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro 
    370                 375                 380                 


Gly 
385 


<210>  54
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  54

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr 
    210                 215                 220                 


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                245                 250                 255     


Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    290                 295                 300                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
305                 310                 315                 320 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                325                 330                 335     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            340                 345                 350         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        355                 360                 365             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    370                 375                 380                 


Cys 
385 


<210>  55
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
    450                 455                 460                 


Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys Ala Met 
465                 470                 475                 480 


Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val Thr Pro 
                485                 490                 495     


Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg Val Thr 
            500                 505                 510         


Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu Glu Lys 
        515                 520                 525             


Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His Val Asp 
    530                 535                 540                 


Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Phe Glu 
545                 550                 555                 560 


Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val Gly Arg 
                565                 570                 575     


Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala 
            580                 585                 590         


Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser 
        595                 600                 605             


Glu Thr Cys Ser Pro Gly 
    610                 


<210>  56
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  56

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Val 
                165                 170                 175     


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            180                 185                 190         


Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly 
    210                 215                 220                 


Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met 
            260                 265                 270         


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    290                 295                 300                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        355                 360                 365             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    370                 375                 380                 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            420                 425                 430         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        435                 440                 445             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    450                 455                 460                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                485                 490                 495     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            500                 505                 510         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        515                 520                 525             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    530                 535                 540                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
545                 550                 555                 560 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            580                 585                 590         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        595                 600                 605             


Ser Leu Ser Leu Gly Lys 
    610                 


<210>  57
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln 
225                 230                 235                 240 


Asp Val Pro Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Ser Gly Glu 
                245                 250                 255     


Asp Pro Glu Met Met Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr 
            260                 265                 270         


Leu Glu Gly Gly Asn Leu Glu Ala Arg Val Thr Val Leu Ile Asp Gly 
        275                 280                 285             


Arg Cys Gln Glu Val Lys Asn Val Leu Glu Lys Thr Asp Glu Pro Gly 
    290                 295                 300                 


Lys Tyr Thr Glu Asp Gly Gly Lys His Val Asp Tyr Ile Ile Arg Ser 
305                 310                 315                 320 


His Val Lys Asp His Tyr Ile Phe Tyr Phe Glu Gly Glu Gly Gln Gly 
                325                 330                 335     


Thr Pro Gly Arg Met Val Ala Leu Val Gly Arg Asp Pro Thr Asn Asn 
            340                 345                 350         


Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu 
        355                 360                 365             


Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro 
    370                 375                 380                 


Gly 
385 


<210>  58
<211>  385
<212>  PRT
<213>  bispecific fusion polypeptide

<400>  58

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr 
    210                 215                 220                 


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                245                 250                 255     


Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    290                 295                 300                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
305                 310                 315                 320 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                325                 330                 335     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            340                 345                 350         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        355                 360                 365             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    370                 375                 380                 


Cys 
385 


<210> 59
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 59

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Thr Asn Thr Ala Tyr
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 60
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 60

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Met Ile Glu Pro Ser Ser Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 61
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 61

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Met Ile Asp Pro Tyr Ser Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ile Ser Asn Thr Ala Tyr
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Asp Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 62
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 62

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Lys Thr Ala Tyr
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Asp Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 63
<211> 117
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 63

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Met Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Ala Ile Asp Thr Ser Asp Ser Tyr Thr Ser Tyr His Gln Asn Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Glu Asp Glu Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      


Ala Arg Arg Asp Tyr Gly Gly Phe Gly Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         


Leu Thr Val Ser Ser
        115         


<210> 64
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 64

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Lys Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 65
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 65

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Arg Ala Ser Gly Tyr Ile Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Asp Lys Thr Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 66
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 66

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Asp Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 67
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 67

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Val Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 68
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 68

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Ser Val Ser Ser
        115     


<210> 69
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 69

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Asn Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 70
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 70

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 71
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 71

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 72
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 72

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Asn Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Lys Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 73
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 73

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 74
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 74

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Val Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Val Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 75
<211> 116
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 75

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Thr Gly Thr Thr Phe Tyr Asn Gln Asp Phe
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Leu
            100                 105                 110         


Thr Val Ser Ser
        115     


<210> 76
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 76

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Val Lys Ala Leu Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser
        115                 120 


<210> 77
<211> 120
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 77

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Thr Phe Thr Val Ser Ser
        115                 120 


<210> 78
<211> 118
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 78

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Ser Gly Ser Pro Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  


Lys Ser Gln Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      


Ala Arg Gly Leu Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         


Thr Leu Thr Val Ser Ser
        115             


<210> 79
<211> 118
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 79

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Ser Gly Ser Pro Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  


Lys Ser Gln Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      


Ala Arg Gly Leu Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         


Thr Leu Thr Val Ser Ser
        115             


<210> 80
<211> 117
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 80

Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              


Met Gly Phe Ile His Tyr Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu
    50                  55                  60                  


Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  


Leu His Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      


Ala Ser Pro Ser Arg Leu Leu Phe Asp Tyr Trp Gly His Gly Thr Thr
            100                 105                 110         


Leu Thr Val Ser Ser
        115         


<210> 81
<211> 113
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 81

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              


Gly Val Ile Trp Gly Val Gly Ser Thr Asn Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      


Ser Asp Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         


Ser
    


<210> 82
<211> 113
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 82

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              


Gly Val Ile Trp Gly Ile Gly Ser Thr Asn Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      


Ser Asp Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         


Ser
    


<210> 83
<211> 114
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 83

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      


Ala Ser Met Ile Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         


Ser Ser
        


<210> 84
<211> 114
<212> PRT
<213> Mus musculus

<220>
<223> heavy chain variable region of PD-1 antibody

<400> 84

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  


Lys Phe His Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      


Ala Ser Met Ile Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         


Ser Ser
        


<210> 85
<211> 108
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 85

Asp Ile Val Leu Thr Gln Thr Pro Ala Ile Met Ser Ala Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 86
<211> 108
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 86

Asp Ile Val Ile Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 87
<211> 108
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 87

Asp Ile Val Met Thr Gln Thr Pro Ala Thr Met Ser Ala Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Asn Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Val Trp
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105             


<210> 88
<211> 108
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 88

Asp Ile Val Met Thr Gln Thr Thr Ala Thr Met Ser Ala Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Asn Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Val Trp
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105             


<210> 89
<211> 108
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 89

Asp Ile Val Leu Thr Gln Ser Thr Ala Ile Met Ser Ala Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Val Asn Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 90
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 90

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 91
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 91

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 92
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 92

Asp Ile Val Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 93
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 93

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 94
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 94

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 95
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 95

Asp Ile Val Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser His Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 96
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 96

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser His Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 97
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 97

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser Ser Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 98
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 98

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Tyr Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Leu Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 99
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 99

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Met Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Tyr Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 100
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 100

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Gly Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 101
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 101

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asp Leu Ala Pro
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Tyr Leu Pro Trp
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 102
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 102

Asp Ile Val Ile Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 103
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 103

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 104
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 104

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 105
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 105

Asp Ile Val Ile Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 106
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 106

Asp Ile Val Met Thr Gln Ser Thr Leu Ser Leu Pro Val Ser Leu Gly
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 107
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 107

Asp Ile Val Leu Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Phe Met Ser Thr Arg Ala Ser Gly Val Ser
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      


Val Asp Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 108
<211> 112
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 108

Asp Ile Val Met Thr Gln Asp Glu Leu Tyr Asn Pro Val Thr Ser Gly
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Phe Met Ser Thr Arg Ala Ser Gly Val Ser
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      


Val Asp Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 109
<211> 113
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 109

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          


Gly Thr Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
            100                 105                 110         


Lys
    


<210> 110
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 110

Asp Ile Val Leu Thr Gln Thr Thr Ala Thr Leu Ser Val Thr Pro Gly
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Val Asn Ser Val Glu Pro
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Tyr Pro Tyr
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 111
<211> 107
<212> PRT
<213> Mus musculus

<220>
<223> light chain variable region of PD-1 antibody

<400> 111

Asp Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Val Thr Pro Gly
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Tyr Pro Tyr
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
            100                 105          


<210> 112
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 113
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 113

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Asn Val Asp Lys Ser Thr Asn Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 114
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 114

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Thr Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Thr Leu Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 115
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 115

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 116
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 116

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              


Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 117
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable region of PD-1 antibody

<400> 117

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
        35                  40                  45              


Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120  


<210> 118
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 118

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 119
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 119

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Thr Gly Ile Pro Ala Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 120
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 120

Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 121
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 121

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 122
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 122

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 123
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable region of PD-1 antibody

<400> 123

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Pro
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 124
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 124

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu
1               5                   10                  15  


<210> 125
<211> 15
<212> PRT

<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 125
Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg
1               5                   10                  15  


<210> 126
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 126

Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu
1               5                   10                  15  


<210> 127
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 127

Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg
1               5                   10                  15  


<210> 128
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 128

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro
1               5                   10                  15  


<210> 129
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 129

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala
1               5                   10                  15  


<210> 130
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 130

Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr
1               5                   10                  15  


<210> 131
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 131

Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala
1               5                   10                  15  


<210> 132
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 132

Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser
1               5                   10                  15  


<210> 133
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 133

Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser
1               5                   10                  15  


<210> 134
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 134

Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu
1               5                   10                  15  


<210> 135
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 135

Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met
1               5                   10                  15  


<210> 136
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 136

Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln
1               5                   10                  15  


<210> 137
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 137

Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
1               5                   10                  15  


<210> 138
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 138

Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp
1               5                   10                  15  


<210> 139
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 139

Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly
1               5                   10                  15  


<210> 140
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 140

Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe
1               5                   10                  15  


<210> 141
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 141

Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu
1               5                   10                  15  


<210> 142
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 142

Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp
1               5                   10                  15  


<210> 143
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 143

Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val
1               5                   10                  15  


<210> 144
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 144

Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg
1               5                   10                  15  


<210> 145
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 145

Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr
1               5                   10                  15  


<210> 146
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 146

Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala
1               5                   10                  15  


<210> 147
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 147

Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro
1               5                   10                  15  


<210> 148
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 148

Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys
1               5                   10                  15  


<210> 149
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 149

Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala
1               5                   10                  15  


<210> 150
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 150

Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr
1               5                   10                  15  


<210> 151
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 151

Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu
1               5                   10                  15  


<210> 152
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 152

Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His
1               5                   10                  15  


<210> 153
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 153

Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
1               5                   10                  15  


<210> 154
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 154
Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe
1               5                   10                  15      


<210>  155
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  155

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser 
            180                 185                 190         


Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys 
    210                 215                 220                 


Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
225                 230                 235                 240 


Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        275                 280                 285             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    290                 295                 300                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
305                 310                 315                 320 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                325                 330                 335     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            340                 345                 350         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        355                 360                 365             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    370                 375                 380                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
385                 390                 395                 400 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                405                 410                 415     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            420                 425                 430         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        435                 440                 445             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    450                 455                 460                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
465                 470                 475                 480 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                485                 490                 495     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            500                 505                 510         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        515                 520                 525             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    530                 535                 540                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
545                 550                 555                 560 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                565                 570                 575     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            580                 585                 590         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
    610                 615                 620                 


Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr 
625                 630                 635                 640 


Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val Thr Pro Met 
                645                 650                 655     


Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met 
            660                 665                 670         


Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu Glu Lys Thr 
        675                 680                 685             


Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr 
    690                 695                 700                 


Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly 
705                 710                 715                 720 


Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp 
                725                 730                 735     


Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly 
            740                 745                 750         


Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu 
        755                 760                 765             


Thr Ser Ser Pro Gly 
    770             


<210>  156
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  156

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser 
            180                 185                 190         


Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys 
    210                 215                 220                 


Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
225                 230                 235                 240 


Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        275                 280                 285             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    290                 295                 300                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
305                 310                 315                 320 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                325                 330                 335     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            340                 345                 350         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        355                 360                 365             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    370                 375                 380                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
385                 390                 395                 400 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                405                 410                 415     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            420                 425                 430         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        435                 440                 445             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    450                 455                 460                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
465                 470                 475                 480 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                485                 490                 495     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            500                 505                 510         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        515                 520                 525             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    530                 535                 540                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
545                 550                 555                 560 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                565                 570                 575     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            580                 585                 590         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
    610                 615                 620                 


Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys Ala Met Thr 
625                 630                 635                 640 


Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val Thr Pro Met 
                645                 650                 655     


Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg Val Thr Val 
            660                 665                 670         


Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu Glu Lys Thr 
        675                 680                 685             


Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His Val Asp Tyr 
    690                 695                 700                 


Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Phe Glu Gly 
705                 710                 715                 720 


Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val Gly Arg Asp 
                725                 730                 735     


Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly 
            740                 745                 750         


Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu 
        755                 760                 765             


Thr Cys Ser Pro Gly 
    770             


<210>  157
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  157

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
    210                 215                 220                 


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
                245                 250                 255     


Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        275                 280                 285             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    290                 295                 300                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
305                 310                 315                 320 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                325                 330                 335     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            340                 345                 350         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        355                 360                 365             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu 
385                 390                 395                 400 


Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr Val 
                405                 410                 415     


Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val Thr Pro Met Thr 
            420                 425                 430         


Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met Asp 
        435                 440                 445             


Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu Glu Lys Thr Asp 
    450                 455                 460                 


Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr Ile 
465                 470                 475                 480 


Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly Glu 
                485                 490                 495     


Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp Pro 
            500                 505                 510         


Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala 
        515                 520                 525             


Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr 
    530                 535                 540                 


Ser Ser Pro Gly 
545             


<210>  158
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  158

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
    210                 215                 220                 


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
                245                 250                 255     


Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        275                 280                 285             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    290                 295                 300                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
305                 310                 315                 320 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                325                 330                 335     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            340                 345                 350         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        355                 360                 365             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu 
385                 390                 395                 400 


Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys Ala Met Thr Val 
                405                 410                 415     


Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val Thr Pro Met Thr 
            420                 425                 430         


Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg Val Thr Val Leu 
        435                 440                 445             


Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu Glu Lys Thr Asp 
    450                 455                 460                 


Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His Val Asp Tyr Ile 
465                 470                 475                 480 


Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr Phe Glu Gly Glu 
                485                 490                 495     


Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val Gly Arg Asp Pro 
            500                 505                 510         


Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala 
        515                 520                 525             


Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr 
    530                 535                 540                 


Cys Ser Pro Gly 
545             


<210>  159
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  159

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Val 
                165                 170                 175     


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            180                 185                 190         


Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly 
    210                 215                 220                 


Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met 
            260                 265                 270         


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    290                 295                 300                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        355                 360                 365             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    370                 375                 380                 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            420                 425                 430         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        435                 440                 445             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    450                 455                 460                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                485                 490                 495     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            500                 505                 510         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        515                 520                 525             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    530                 535                 540                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
545                 550                 555                 560 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            580                 585                 590         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        595                 600                 605             


Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly 
625                 630                 635                 640 


Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile 
                645                 650                 655     


Asp Asp Val Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly 
            660                 665                 670         


Asn Leu Glu Ala Lys Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu 
        675                 680                 685             


Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala 
    690                 695                 700                 


Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp 
705                 710                 715                 720 


His Tyr Ile Phe Tyr Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro 
                725                 730                 735     


Gly Val Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu 
            740                 745                 750         


Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser 
        755                 760                 765             


Ile Leu Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
    770                 775                 780     


<210>  160
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  160

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Val 
                165                 170                 175     


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            180                 185                 190         


Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro 
        195                 200                 205             


Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly 
    210                 215                 220                 


Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met 
            260                 265                 270         


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    290                 295                 300                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        355                 360                 365             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    370                 375                 380                 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            420                 425                 430         


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
        435                 440                 445             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
    450                 455                 460                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                485                 490                 495     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            500                 505                 510         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
        515                 520                 525             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    530                 535                 540                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
545                 550                 555                 560 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
                565                 570                 575     


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
            580                 585                 590         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        595                 600                 605             


Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly 
625                 630                 635                 640 


Thr Trp Tyr Leu Lys Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met 
                645                 650                 655     


Met Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly 
            660                 665                 670         


Asn Leu Glu Ala Arg Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu 
        675                 680                 685             


Val Lys Asn Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu 
    690                 695                 700                 


Asp Gly Gly Lys His Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp 
705                 710                 715                 720 


His Tyr Ile Phe Tyr Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg 
                725                 730                 735     


Met Val Ala Leu Val Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu 
            740                 745                 750         


Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser 
        755                 760                 765             


Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly 
    770                 775                 780     


<210>  161
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  161

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr 
    210                 215                 220                 


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                245                 250                 255     


Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    290                 295                 300                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
305                 310                 315                 320 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                325                 330                 335     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            340                 345                 350         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        355                 360                 365             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    370                 375                 380                 


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
                405                 410                 415     


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            420                 425                 430         


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        435                 440                 445             


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    450                 455                 460                 


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
465                 470                 475                 480 


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                485                 490                 495     


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            500                 505                 510         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        515                 520                 525             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    530                 535                 540                 


Gln Ser Glu Thr Ser Ser Pro Gly 
545                 550         


<210>  162
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bispecific fusion polypeptide

<400>  162

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            180                 185                 190         


Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr 
    210                 215                 220                 


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                245                 250                 255     


Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    290                 295                 300                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
305                 310                 315                 320 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                325                 330                 335     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            340                 345                 350         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        355                 360                 365             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    370                 375                 380                 


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
                405                 410                 415     


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            420                 425                 430         


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        435                 440                 445             


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    450                 455                 460                 


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
465                 470                 475                 480 


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                485                 490                 495     


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            500                 505                 510         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        515                 520                 525             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    530                 535                 540                 


Gln Ser Glu Thr Cys Ser Pro Gly 
545                 550         


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  163

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  164

Ile Asp Pro Gly Thr Gly Gly Thr 
1               5               


<210>  165
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  165

Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  166

Gln Thr Ile Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  167

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  168

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  169
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  169

Ile Asp Pro Ser Asn Ser Glu Thr 
1               5               


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  170

Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr 
1               5                   10              


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  171

Ser Ser Val Ser Ser Asn Tyr 
1               5           


<210>  172
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  172

His Gln Trp Ser Ser Tyr Pro Pro 
1               5               


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  173

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  174

Ile Asp Thr Ser Asp Ser Tyr Thr 
1               5               


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  175

Ala Arg Arg Asp Tyr Gly Gly Phe Gly Tyr 
1               5                   10  


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  176

Gln Asp Ile Ser Ser Tyr 
1               5       


<210>  177
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  177

Gln Gln Tyr Ser Glu Leu Pro Trp 
1               5               


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  178

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  179

Ile Asp Pro Asn Asn Gly Asp Thr 
1               5               


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  180

Ala Arg Trp Arg Ser Ser Met Asp Tyr 
1               5                   


<210>  181
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  181

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  182

Gln Gln Tyr Ser Asn Leu Pro Trp 
1               5               


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  183

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  184

Ile Thr Tyr Ser Gly Ser Pro 
1               5           


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  185

Ala Arg Gly Leu Gly Gly His Tyr Phe Asp Tyr 
1               5                   10      


<210>  186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  186

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  187

Gln Asn Gly Arg Ser Tyr Pro Tyr 
1               5               


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 of anti-PD1 antibody

<400>  188

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 of anti-PD1 antibody

<400>  189

Ile Trp Arg Gly Gly Asn Thr 
1               5           


<210>  190
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 of anti-PD1 antibody

<400>  190

Ala Ala Ser Met Ile Gly Gly Tyr 
1               5               


<210>  191
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 of anti-PD1 antibody

<400>  191

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 of anti-PD1 antibody

<400>  192

Phe Gln Gly Ser His Val Pro Leu 
1               5               

