                               SEQUENCE LISTING

<110> MEDIMMUNE LIMITED
      ASTRAZENECA PHARMACEUTICALS LP

<120> METHODS FOR TREATING HEPCIDIN-MEDIATED DISORDERS

<130> 32601-34392/PCT

<140> PCT/US2016/044528
<141> 2016-07-28

<150> 62/268,788
<151> 2015-12-17

<150> 62/199,434
<151> 2015-07-31

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 84
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Leu Ser Ser Gln Ile Trp Ala Ala Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Ser Leu Thr Ser Gly Ser Val Phe Pro Gln Gln Thr Gly 
            20                  25                  30          


Gln Leu Ala Glu Leu Gln Pro Gln Asp Arg Ala Gly Ala Arg Ala Ser 
        35                  40                  45              


Trp Met Pro Met Phe Gln Arg Arg Arg Arg Arg Asp Thr His Phe Pro 
    50                  55                  60                  


Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
65                  70                  75                  80  


Cys Cys Lys Thr 
                


<210> 2
<211> 824
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Ala Leu Arg Ala Asp Ala Val Ala Leu Phe Tyr Gly Trp Arg Asn Gln 
705                 710                 715                 720 


Gly Ser Glu Thr Cys Cys Cys Pro Ile Ser Asn Ala Leu Gln Lys Ala 
                725                 730                 735     


Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr 
            740                 745                 750         


Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys 
        755                 760                 765             


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Ala Leu 
    770                 775                 780                 


Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly Leu Gly Cys 
785                 790                 795                 800 


Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr Gly Val Ile 
                805                 810                 815     


Ser Trp Ile Gln Gln Val Val Thr 
            820                 


<210> 3
<211> 824
<212> PRT
<213> Homo sapiens

<400> 3
Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Ala Leu Arg Ala Asp Ala Val Ala Leu Phe Tyr Gly Trp Arg Asn Gln 
705                 710                 715                 720 


Gly Ser Glu Thr Cys Cys Cys Pro Ile Ser Asn Ala Leu Gln Lys Val 
                725                 730                 735     


Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr 
            740                 745                 750         


Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys 
        755                 760                 765             


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Ala Leu 
    770                 775                 780                 


Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly Leu Gly Cys 
785                 790                 795                 800 


Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr Gly Val Ile 
                805                 810                 815     


Ser Trp Ile Gln Gln Val Val Thr 
            820                 


<210> 4
<211> 3196
<212> DNA
<213> Homo sapiens

<400> 4
ggacaaacag aggctcctga ggcctgtgtg caggcccggc acctatctgc cgctcccaaa       60

ggatgcccgt ggccgaggcc ccccaggtgg ctggcgggca gggggacgga ggtgatggcg      120

aggaagcgga gccggagggg atgttcaagg cctgtgagga ctccaagaga aaagcccggg      180

gctacctccg cctggtgccc ctgtttgtgc tgctggccct gctcgtgctg gcttcggcgg      240

gggtgctact ctggtatttc ctagggtaca aggcggaggt gatggtcagc caggtgtact      300

caggcagtct gcgtgtactc aatcgccact tctcccagga tcttacccgc cgggaatcta      360

gtgccttccg cagtgaaacc gccaaagccc agaagatgct caaggagctc atcaccagca      420

cccgcctggg aacttactac aactccagct ccgtctattc ctttggggag ggacccctca      480

cctgcttctt ctggttcatt ctccaaatcc ccgagcaccg ccggctgatg ctgagccccg      540

aggtggtgca ggcactgctg gtggaggagc tgctgtccac agtcaacagc tcggctgccg      600

tcccctacag ggccgagtac gaagtggacc ccgagggcct agtgatcctg gaagccagtg      660

tgaaagacat agctgcattg aattccacgc tgggttgtta ccgctacagc tacgtgggcc      720

agggccaggt cctccggctg aaggggcctg accacctggc ctccagctgc ctgtggcacc      780

tgcagggccc caaggacctc atgctcaaac tccggctgga gtggacgctg gcagagtgcc      840

gggaccgact ggccatgtat gacgtggccg ggcccctgga gaagaggctc atcacctcgg      900

tgtacggctg cagccgccag gagcccgtgg tggaggttct ggcgtcgggg gccatcatgg      960

cggtcgtctg gaagaagggc ctgcacagct actacgaccc cttcgtgctc tccgtgcagc     1020

cggtggtctt ccaggcctgt gaagtgaacc tgacgctgga caacaggctc gactcccagg     1080

gcgtcctcag caccccgtac ttccccagct actactcgcc ccaaacccac tgctcctggc     1140

acctcacggt gccctctctg gactacggct tggccctctg gtttgatgcc tatgcactga     1200

ggaggcagaa gtatgatttg ccgtgcaccc agggccagtg gacgatccag aacaggaggc     1260

tgtgtggctt gcgcatcctg cagccctacg ccgagaggat ccccgtggtg gccacggccg     1320

ggatcaccat caacttcacc tcccagatct ccctcaccgg gcccggtgtg cgggtgcact     1380

atggcttgta caaccagtcg gacccctgcc ctggagagtt cctctgttct gtgaatggac     1440

tctgtgtccc tgcctgtgat ggggtcaagg actgccccaa cggcctggat gagagaaact     1500

gcgtttgcag agccacattc cagtgcaaag aggacagcac atgcatctca ctgcccaagg     1560

tctgtgatgg gcagcctgat tgtctcaacg gcagcgacga agagcagtgc caggaagggg     1620

tgccatgtgg gacattcacc ttccagtgtg aggaccggag ctgcgtgaag aagcccaacc     1680

cgcagtgtga tgggcggccc gactgcaggg acggctcgga tgaggagcac tgtgactgtg     1740

gcctccaggg cccctccagc cgcattgttg gtggagctgt gtcctccgag ggtgagtggc     1800

catggcaggc cagcctccag gttcggggtc gacacatctg tgggggggcc ctcatcgctg     1860

accgctgggt gataacagct gcccactgct tccaggagga cagcatggcc tccacggtgc     1920

tgtggaccgt gttcctgggc aaggtgtggc agaactcgcg ctggcctgga gaggtgtcct     1980

tcaaggtgag ccgcctgctc ctgcacccgt accacgaaga ggacagccat gactacgacg     2040

tggcgctgct gcagctcgac cacccggtgg tgcgctcggc cgccgtgcgc cccgtctgcc     2100

tgcccgcgcg ctcccacttc ttcgagcccg gcctgcactg ctggattacg ggctggggcg     2160

ccttgcgcga gggcgcccta cgggcggatg ctgtggccct attttatgga tggagaaacc     2220

aaggctcaga gacatgttgc tgccccatca gcaacgctct gcagaaagtg gatgtgcagt     2280

tgatcccaca ggacctgtgc agcgaggtct atcgctacca ggtgacgcca cgcatgctgt     2340

gtgccggcta ccgcaagggc aagaaggatg cctgtcaggg tgactcaggt ggtccgctgg     2400

tgtgcaaggc actcagtggc cgctggttcc tggcggggct ggtcagctgg ggcctgggct     2460

gtggccggcc taactacttc ggcgtctaca cccgcatcac aggtgtgatc agctggatcc     2520

agcaagtggt gacctgagga actgcccccc tgcaaagcag ggcccacctc ctggactcag     2580

agagcccagg gcaactgcca agcaggggga caagtattct ggcggggggt gggggagaga     2640

gcaggccctg tggtggcagg aggtggcatc ttgtctcgtc cctgatgtct gctccagtga     2700

tggcaggagg atggagaagt gccagcagct gggggtcaag acgtcccctg aggacccagg     2760

cccacaccca gcccttctgc ctcccaattc tctctcctcc gtccccttcc tccactgctg     2820

cctaatgcaa ggcagtggct cagcagcaag aatgctggtt ctacatcccg aggagtgtct     2880

gaggtgcgcc ccactctgta cagaggctgt ttgggcagcc ttgcctccag agagcagatt     2940

ccagcttcgg aagcccctgg tctaacttgg gatctgggaa tggaaggtgc tcccatcgga     3000

ggggaccctc agagccctgg agactgccag gtgggcctgc tgccactgta agccaaaagg     3060

tggggaagtc ctgactccag ggtccttgcc ccacccctgc ctgccacctg ggccctcaca     3120

gcccagaccc tcactgggag gtgagctcag ctgccctttg gaataaagct gcctgatcca     3180

aaaaaaaaaa aaaaaa                                                     3196


<210> 5
<211> 3196
<212> DNA
<213> Homo sapiens

<400> 5
ggacaaacag aggctcctga ggcctgtgtg caggcccggc acctatctgc cgctcccaaa       60

ggatgcccgt ggccgaggcc ccccaggtgg ctggcgggca gggggacgga ggtgatggcg      120

aggaagcgga gccggagggg atgttcaagg cctgtgagga ctccaagaga aaagcccggg      180

gctacctccg cctggtgccc ctgtttgtgc tgctggccct gctcgtgctg gcttcggcgg      240

gggtgctact ctggtatttc ctagggtaca aggcggaggt gatggtcagc caggtgtact      300

caggcagtct gcgtgtactc aatcgccact tctcccagga tcttacccgc cgggaatcta      360

gtgccttccg cagtgaaacc gccaaagccc agaagatgct caaggagctc atcaccagca      420

cccgcctggg aacttactac aactccagct ccgtctattc ctttggggag ggacccctca      480

cctgcttctt ctggttcatt ctccaaatcc ccgagcaccg ccggctgatg ctgagccccg      540

aggtggtgca ggcactgctg gtggaggagc tgctgtccac agtcaacagc tcggctgccg      600

tcccctacag ggccgagtac gaagtggacc ccgagggcct agtgatcctg gaagccagtg      660

tgaaagacat agctgcattg aattccacgc tgggttgtta ccgctacagc tacgtgggcc      720

agggccaggt cctccggctg aaggggcctg accacctggc ctccagctgc ctgtggcacc      780

tgcagggccc caaggacctc atgctcaaac tccggctgga gtggacgctg gcagagtgcc      840

gggaccgact ggccatgtat gacgtggccg ggcccctgga gaagaggctc atcacctcgg      900

tgtacggctg cagccgccag gagcccgtgg tggaggttct ggcgtcgggg gccatcatgg      960

cggtcgtctg gaagaagggc ctgcacagct actacgaccc cttcgtgctc tccgtgcagc     1020

cggtggtctt ccaggcctgt gaagtgaacc tgacgctgga caacaggctc gactcccagg     1080

gcgtcctcag caccccgtac ttccccagct actactcgcc ccaaacccac tgctcctggc     1140

acctcacggt gccctctctg gactacggct tggccctctg gtttgatgcc tatgcactga     1200

ggaggcagaa gtatgatttg ccgtgcaccc agggccagtg gacgatccag aacaggaggc     1260

tgtgtggctt gcgcatcctg cagccctacg ccgagaggat ccccgtggtg gccacggccg     1320

ggatcaccat caacttcacc tcccagatct ccctcaccgg gcccggtgtg cgggtgcact     1380

atggcttgta caaccagtcg gacccctgcc ctggagagtt cctctgttct gtgaatggac     1440

tctgtgtccc tgcctgtgat ggggtcaagg actgccccaa cggcctggat gagagaaact     1500

gcgtttgcag agccacattc cagtgcaaag aggacagcac atgcatctca ctgcccaagg     1560

tctgtgatgg gcagcctgat tgtctcaacg gcagcgacga agagcagtgc caggaagggg     1620

tgccatgtgg gacattcacc ttccagtgtg aggaccggag ctgcgtgaag aagcccaacc     1680

cgcagtgtga tgggcggccc gactgcaggg acggctcgga tgaggagcac tgtgactgtg     1740

gcctccaggg cccctccagc cgcattgttg gtggagctgt gtcctccgag ggtgagtggc     1800

catggcaggc cagcctccag gttcggggtc gacacatctg tgggggggcc ctcatcgctg     1860

accgctgggt gataacagct gcccactgct tccaggagga cagcatggcc tccacggtgc     1920

tgtggaccgt gttcctgggc aaggtgtggc agaactcgcg ctggcctgga gaggtgtcct     1980

tcaaggtgag ccgcctgctc ctgcacccgt accacgaaga ggacagccat gactacgacg     2040

tggcgctgct gcagctcgac cacccggtgg tgcgctcggc cgccgtgcgc cccgtctgcc     2100

tgcccgcgcg ctcccacttc ttcgagcccg gcctgcactg ctggattacg ggctggggcg     2160

ccttgcgcga gggcgcccta cgggcggatg ctgtggccct attttatgga tggagaaacc     2220

aaggctcaga gacatgttgc tgccccatca gcaacgctct gcagaaagtg gatgtgcagt     2280

tgatcccaca ggacctgtgc agcgaggtct atcgctacca agtgacgcca cgcatgctgt     2340

gtgccggcta ccgcaagggc aagaaggatg cctgtcaggg tgactcaggt ggtccgctgg     2400

tgtgcaaggc actcagtggc cgctggttcc tggcggggct ggtcagctgg ggcctgggct     2460

gtggccggcc taactacttc ggcgtctaca cccgcatcac aggtgtgatc agctggatcc     2520

agcaagtggt gacctgagga actgcccccc tgcaaagcag ggcccacctc ctggactcag     2580

agagcccagg gcaactgcca agcaggggga caagtattct ggcggggggt gggggagaga     2640

gcaggccctg tggtggcagg aggtggcatc ttgtctcgtc cctgatgtct gctccagtga     2700

tggcaggagg atggagaagt gccagcagct gggggtcaag acgtcccctg aggacccagg     2760

cccacaccca gcccttctgc ctcccaattc tctctcctcc gtccccttcc tccactgctg     2820

cctaatgcaa ggcagtggct cagcagcaag aatgctggtt ctacatcccg aggagtgtct     2880

gaggtgcgcc ccactctgta cagaggctgt ttgggcagcc ttgcctccag agagcagatt     2940

ccagcttcgg aagcccctgg tctaacttgg gatctgggaa tggaaggtgc tcccatcgga     3000

ggggaccctc agagccctgg agactgccag gtgggcctgc tgccactgta agccaaaagg     3060

tggggaagtc ctgactccag ggtccttgcc ccacccctgc ctgccacctg ggccctcaca     3120

gcccagaccc tcactgggag gtgagctcag ctgccctttg gaataaagct gcctgatcca     3180

aaaaaaaaaa aaaaaa                                                     3196


<210> 6
<211> 277
<212> PRT
<213> Homo sapiens

<400> 6
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210> 7
<211> 1201
<212> DNA
<213> Homo sapiens

<400> 7
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210> 8
<211> 468
<212> PRT
<213> Homo sapiens

<400> 8
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210> 9
<211> 918
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210> 10
<211> 193
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210> 11
<211> 224
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Asn Tyr Met Ile 
1               5   


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Asp Leu Tyr Tyr Tyr Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Trp Ala Asp Asp His Pro Pro Trp Ile Asp Leu 
1               5                   10      


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Gln Ser Trp Leu Gly Gly Ser 
1               5               


<210> 18
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Asn 
            20                  25                  30          


Tyr Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Leu Tyr Tyr Tyr Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Ile Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ala Asp Asp His Pro Pro Trp Ile Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile 
                245                 250                 255     


Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 19
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Leu Gly Gly Ser 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 20
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 20
cggctctgca gccttg                                                       16


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
cttccaggag cgagatcccg ctaa                                              24


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gcatgaggtc cttggggccc tgcag                                             25


<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
ctgcagggcc ccaaggacct catgc                                             25


<210> 24
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
cctggtagcg ataggcctcg ctgcacagg                                         29


<210> 25
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cctgtgcagc gaggcctatc gctaccagg                                         29


