                         SEQUENCE LISTING

<110>  Universit Franois Rabelais
 
<120>  IgG1 ET LEUR UTILISATION THERAPEUTIQUE

<130>  IFB 15 BG SGC MUMA

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rgion constante d'IgG1 G1m3,1

<400>  1

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  2
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rgion constante d'IgG1 G1m3

<400>  2

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  3
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rgion constante d'IgG1 G1m17

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  4
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rgion constante d'IgG1 G1m17,1

<400>  4

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  5
<211>  4426
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vecteur

<400>  5
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggtga attcgatatc tcgagtgcta gcaccaaggg cccatcggtc      600

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      660

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      720

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      780

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      840

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      900

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      960

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1020

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1080

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1140

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1200

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1260

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1320

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1380

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1440

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1500

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1560

ggtaaatgag tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca     1620

caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat     1680

ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt     1740

ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg     1800

gtatggaatt aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta     1860

cttgaatcct tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc     1920

attagctgtt tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa     1980

ggtttgaact agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt     2040

tttagtaaaa tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt     2100

attaggcaga atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac     2160

ttagggaaca aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta     2220

tcctcagtcc tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc     2280

gaactcccgc ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg     2340

gaagttcgtg gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca     2400

cacccaggcc agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt     2460

cacgtcgtcc cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag     2520

ccggtcggtc cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc     2580

actggtcaac ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt     2640

acaattgcta tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt     2700

caaactaggg ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca     2760

ccctttccca ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa     2820

gcttgagaca gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt     2880

ttatggtgcg ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg     2940

tggcaggagg cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc     3000

cccccgcccc aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg     3060

ggcttggggg ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt     3120

ggagacttgg aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa     3180

accgcatcat catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt     3240

cccataaggt catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa     3300

tagggggcgt acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta     3360

aatactccac ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg     3420

tcattattga cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg     3480

taagttatgt aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc     3540

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     3600

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     3660

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     3720

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     3780

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     3840

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     3900

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     3960

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     4020

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     4080

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     4140

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     4200

gtggaacgaa aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc     4260

agcggccgca ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa     4320

tcgtaactaa catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag     4380

gctgtcccca gtgcaagtgc aggtgccaga acatttctct atcgaa                    4426


<210>  6
<211>  3813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vecteur

<400>  6
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggtca ccatggaaat caaacgtacg gtggctgcac catctgtctt      600

catcttcccg ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct      660

gaataacttc tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc      720

gggtaactcc caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag      780

cagcaccctg acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt      840

cacccatcag ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttagag      900

ggagctagct cgacatgata agatacattg atgagtttgg acaaaccaca actagaatgc      960

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtgaaatttg     1020

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     1080

ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta     1140

aaacctctac aaatgtggta tggaattaat tctaaaatac agcatagcaa aactttaacc     1200

tccaaatcaa gcctctactt gaatcctttt ctgagggatg aataaggcat aggcatcagg     1260

ggctgttgcc aatgtgcatt agctgtttgc agcctcacct tctttcatgg agtttaagat     1320

atagtgtatt ttcccaaggt ttgaactagc tcttcatttc tttatgtttt aaatgcactg     1380

acctcccaca ttcccttttt agtaaaatat tcagaaataa tttaaataca tcattgcaat     1440

gaaaataaat gttttttatt aggcagaatc cagatgctca aggcccttca taatatcccc     1500

cagtttagta gttggactta gggaacaaag gaacctttaa tagaaattgg acagcaagaa     1560

agcgagcttc tagctttagt tcctggtgta cttgaggggg atgagttcct caatggtggt     1620

tttgaccagc ttgccattca tctcaatgag cacaaagcag tcaggagcat agtcagagat     1680

gagctctctg cacatgccac aggggctgac caccctgatg gatctgtcca cctcatcaga     1740

gtaggggtgc ctgacagcca caatggtgtc aaagtccttc tgcccgttgc tcacagcaga     1800

cccaatggca atggcttcag cacagacagt gaccctgcca atgtaggcct caatgtggac     1860

agcagagatg atctccccag tcttggtcct gatggccgcc ccgacatggt gcttgttgtc     1920

ctcatagagc atggtgatct tctcagtggc gacctccacc agctccagat cctgctgaga     1980

gatgttgaag gtcttcatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt     2040

acaattgcta tagtgagttg tattatacta tgcttatgat taattgtcaa actagggctg     2100

cagggttcat agtgccactt ttcctgcact gccccatctc ctgcccaccc tttcccaggc     2160

atagacagtc agtgacttac caaactcaca ggagggagaa ggcagaagct tgagacagac     2220

ccgcgggacc gccgaactgc gaggggacgt ggctagggcg gcttctttta tggtgcgccg     2280

gccctcggag gcagggcgct cggggaggcc tagcggccaa tctgcggtgg caggaggcgg     2340

ggccgaaggc cgtgcctgac caatccggag cacataggag tctcagcccc ccgccccaaa     2400

gcaaggggaa gtcacgcgcc tgtagcgcca gcgtgttgtg aaatgggggc ttgggggggt     2460

tggggccctg actagtcaaa acaaactccc attgacgtca atggggtgga gacttggaaa     2520

tccccgtgag tcaaaccgct atccacgccc attgatgtac tgccaaaacc gcatcatcat     2580

ggtaatagcg atgactaata cgtagatgta ctgccaagta ggaaagtccc ataaggtcat     2640

gtactgggca taatgccagg cgggccattt accgtcattg acgtcaatag ggggcgtact     2700

tggcatatga tacacttgat gtactgccaa gtgggcagtt taccgtaaat actccaccca     2760

ttgacgtcaa tggaaagtcc ctattggcgt tactatggga acatacgtca ttattgacgt     2820

caatgggcgg gggtcgttgg gcggtcagcc aggcgggcca tttaccgtaa gttatgtaac     2880

gcctgcaggt taattaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     2940

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     3000

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     3060

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     3120

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     3180

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     3240

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     3300

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     3360

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     3420

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     3480

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     3540

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     3600

tcacgttaag ggattttggt catggctagt taattaacat ttaaatcagc ggccgcaata     3660

aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgaatcg taactaacat     3720

acgctctcca tcaaaacaaa acgaaacaaa acaaactagc aaaataggct gtccccagtg     3780

caagtgcagg tgccagaaca tttctctatc gaa                                  3813


