                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       LIU, George
       KOLAR, Stacey
 
<120>  COMPOSITIONS AND METHODS FOR TREATING ACNE

<130>  065472-000544WO00

<150>  62/198,904
<151>  2015-07-30

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  813
<212>  PRT
<213>  Propionibacterium acnes

<400>  1

Met Phe Gly Thr Pro Ser Arg Arg Thr Phe Leu Thr Ala Ser Ala Leu 
1               5                   10                  15      


Ser Ala Met Ala Leu Ala Ala Ser Pro Thr Val Thr Asp Ala Ile Ala 
            20                  25                  30          


Ala Pro Gly Pro Asp Ser Trp Ser Ala Leu Cys Glu Arg Trp Ile Asp 
        35                  40                  45              


Ile Ile Thr Gly Arg Arg Ala Ala Arg Thr Ser Asp Pro Arg Ala Arg 
    50                  55                  60                  


Ala Ile Ile Ala Lys Thr Asp Arg Lys Val Ala Glu Ile Leu Thr Asp 
65                  70                  75                  80  


Leu Val Ser Gly Ser Ser Arg Gln Thr Val Leu Ile Ser Ala Asp Leu 
                85                  90                  95      


Arg Lys Glu Gln Ser Pro Phe Ile Thr Lys Thr Ala Arg Ala Ile Glu 
            100                 105                 110         


Ser Met Ala Cys Ala Trp Ala Thr Pro Gly Ser Ser Tyr His Lys Asp 
        115                 120                 125             


Pro Glu Ile Leu Ser Ala Cys Ile Glu Gly Leu Arg Asp Phe Cys Arg 
    130                 135                 140                 


Leu Arg Tyr Asn Pro Ser Gln Asp Glu Tyr Gly Asn Trp Trp Asp Trp 
145                 150                 155                 160 


Glu Asp Gly Ala Ser Arg Ala Val Ala Asp Val Met Cys Ile Leu His 
                165                 170                 175     


Asp Val Leu Pro Pro Glu Val Met Ser Ala Ala Ala Ala Gly Ile Asp 
            180                 185                 190         


His Phe Ile Pro Asp Pro Trp Phe Gln Gln Pro Ala Ser Val Lys Pro 
        195                 200                 205             


Thr Ala Asn Pro Val Gln Pro Val Val Ser Thr Gly Ala Asn Arg Met 
    210                 215                 220                 


Asp Leu Thr Arg Ala Val Met Cys Arg Ser Ile Ala Thr Gly Asp Glu 
225                 230                 235                 240 


Lys Arg Leu Arg His Ala Val Asp Gly Leu Pro Asp Ala Trp Arg Val 
                245                 250                 255     


Thr Thr Glu Gly Asp Gly Phe Arg Ala Asp Gly Gly Phe Ile Gln His 
            260                 265                 270         


Ser His Ile Pro Tyr Thr Gly Gly Tyr Gly Asp Val Leu Phe Ser Gly 
        275                 280                 285             


Leu Ala Met Leu Phe Pro Leu Val Ser Gly Met Arg Phe Asp Ile Val 
    290                 295                 300                 


Glu Ser Ala Arg Lys Ala Phe His Asp Gln Val Glu Arg Gly Phe Ile 
305                 310                 315                 320 


Pro Val Met Tyr Asn Gly Gln Ile Leu Asp Asp Val Arg Gly Arg Ser 
                325                 330                 335     


Ile Ser Arg Ile Asn Glu Ser Ala Ala Met His Gly Ile Ser Ile Ala 
            340                 345                 350         


Arg Ala Met Leu Met Met Ala Asp Ala Leu Pro Thr His Arg Ala Glu 
        355                 360                 365             


Gln Trp Arg Gly Ile Val His Gly Trp Met Ala Arg Asn Thr Phe Asp 
    370                 375                 380                 


His Leu Ser Glu Pro Ser Thr Leu Val Asp Ile Ser Leu Phe Asp Ala 
385                 390                 395                 400 


Ala Ala Lys Ala Arg Pro Val Pro Glu Ser Ser Thr Pro Ser Tyr Phe 
                405                 410                 415     


Ala Ser Met Asp Arg Leu Val His Arg Thr Ala Asp Trp Leu Ile Thr 
            420                 425                 430         


Val Ser Asn Cys Ser Asp Arg Ile Ala Trp Tyr Glu Tyr Gly Asn Gly 
        435                 440                 445             


Glu Asn Glu Trp Ala Ser Arg Thr Ser Gln Gly Met Arg Tyr Leu Leu 
    450                 455                 460                 


Leu Pro Gly Asp Met Gly Gln Tyr Glu Asp Gly Tyr Trp Ala Thr Val 
465                 470                 475                 480 


Asp Tyr Ser Ala Pro Thr Gly Thr Thr Val Asp Ser Thr Pro Leu Lys 
                485                 490                 495     


Arg Ala Val Gly Ala Ser Trp Ala Ala Lys Thr Pro Thr Asn Glu Trp 
            500                 505                 510         


Ser Gly Gly Leu Ala Ser Gly Ser Trp Ser Ala Ala Ala Ser His Ile 
        515                 520                 525             


Thr Ser Gln Asp Ser Ala Leu Lys Ala Arg Arg Leu Trp Val Gly Leu 
    530                 535                 540                 


Lys Asp Ala Met Val Glu Leu Thr Thr Asp Val Thr Thr Asp Ala Ser 
545                 550                 555                 560 


Arg Ala Ile Thr Val Val Glu His Arg Lys Val Ala Ser Ser Ser Thr 
                565                 570                 575     


Lys Leu Leu Val Asp Gly Asn Arg Val Ser Ser Ala Thr Ser Phe Gln 
            580                 585                 590         


Asn Pro Arg Trp Ala His Leu Asp Gly Val Gly Gly Tyr Val Phe Ala 
        595                 600                 605             


Thr Asp Thr Asp Leu Ser Ala Asp Val Ala Thr Arg Lys Gly Thr Trp 
    610                 615                 620                 


Ile Asp Val Asn Pro Ser Arg Lys Val Lys Gly Ala Asp Glu Val Ile 
625                 630                 635                 640 


Glu Arg Ala Tyr Ala Ser Leu His Val Thr His His Asp Arg Pro Val 
                645                 650                 655     


Ala Trp Ala Leu Leu Pro Thr Ala Ser Arg Ser His Thr Met Ala Leu 
            660                 665                 670         


Ala Thr Arg Pro Gly Val Glu Pro Phe Thr Val Leu Arg Asn Asp Ala 
        675                 680                 685             


Thr Val Gln Ala Val Arg Ser Ala Gly Ala Leu Leu Thr Lys Asp Pro 
    690                 695                 700                 


Thr Val Val Thr Thr Leu Ala Phe Trp Lys Pro Ala Thr Cys Gly Gly 
705                 710                 715                 720 


Val Ala Val Asn Arg Pro Ala Leu Val Gln Thr Arg Glu Ser Ala Asn 
                725                 730                 735     


Gln Met Glu Val Val Ile Val Glu Pro Thr Gln Lys Arg Gly Ser Leu 
            740                 745                 750         


Thr Val Thr Ile Glu Gly Ser Trp Lys Val Lys Thr Ala Asp Ser His 
        755                 760                 765             


Val Asp Val Ser Cys Glu Asn Ala Ala Gly Thr Leu His Val Asp Thr 
    770                 775                 780                 


Ala Gly Leu Gly Gly Gln Ser Val Arg Val Thr Leu Ala Arg Gln Val 
785                 790                 795                 800 


Thr Gln Thr Pro Ser Gly Gly Gly Arg His Asp Arg Ala 
                805                 810             


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Phe Leu Thr Ala Ser Ala Leu Ser Ala Met Ala Leu Ala Ala Ser Pro 
1               5                   10                  15      


Thr Val Thr Asp Ala Ile Ala Ala Pro 
            20                  25  


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Ser Trp Ser Ala Leu Cys Glu Arg 
1               5               


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Lys Val Ala Glu Ile Leu Thr Asp Leu Val Ser Gly Ser Ser Arg Gln 
1               5                   10                  15      


Thr Val Leu Ile Ser Ala 
            20          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Glu Ser Met Ala Cys Ala Trp 
1               5           


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Lys Asp Pro Glu Ile Leu Ser Ala Cys Ile Glu Gly Leu Arg Asp Phe 
1               5                   10                  15      


Cys Arg Leu Arg Tyr 
            20      


<210>  7
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Ala Ser Arg Ala Val Ala Asp Val Met Cys Ile Leu His Asp Val Leu 
1               5                   10                  15      


Pro Pro Glu Val Met Ser Ala Ala Ala Ala Gly Ile Asp His Phe Ile 
            20                  25                  30          


Pro Asp Pro Trp Phe Gln Gln Pro Ala Ser Val Lys Pro Thr Ala Asn 
        35                  40                  45              


Pro Val Gln Pro Val Val Ser 
    50                  55  


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Leu Thr Arg Ala Val Met Cys Arg Ser 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Leu Arg His Ala Val Asp Gly 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Phe Ile Gln His Ser His Ile Pro Tyr 
1               5                   


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Tyr Gly Asp Val Leu Phe Ser Gly Leu Ala Met Leu Phe Pro Leu Val 
1               5                   10                  15      


Ser Gly Met Arg Phe Asp Ile Val Glu Ser 
            20                  25      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Glu Arg Gly Phe Ile Pro Val Met Tyr Asn Gly 
1               5                   10      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Ala Met His Gly Ile Ser Ile Ala Arg 
1               5                   


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Trp Arg Gly Ile Val His Gly 
1               5           


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Phe Asp His Leu Ser Glu Pro Ser Thr Leu Val Asp Ile Ser Leu Phe 
1               5                   10                  15      


Asp Ala Ala Ala Lys Ala Arg Pro Val Pro Glu 
            20                  25          


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Asp Arg Leu Val His Arg Thr Ala Asp Trp Leu Ile Thr Val Ser 
1               5                   10                  15      


Asn Cys Ser Asp Arg 
            20      


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Gly Met Arg Tyr Leu Leu Leu Pro 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Tyr Trp Ala Thr Val Asp Tyr 
1               5           


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19

Pro Leu Lys Arg Ala Val Gly Ala 
1               5               


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Ser Ala Ala Ala Ser His Ile Thr Ser Gln Asp Ser Ala Leu Lys Ala 
1               5                   10                  15      


Arg Arg Leu Trp Val Gly Leu Lys Asp Ala Met Val 
            20                  25              


<210>  21
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Arg Ala Ile Thr Val Val Glu His Arg Lys Val Ala Ser Ser Ser Thr 
1               5                   10                  15      


Lys Leu Leu Val Asp Gly 
            20          


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

His Leu Asp Gly Val Gly Gly Tyr Val Phe Ala 
1               5                   10      


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Gly Ala Asp Glu Val Ile Glu Arg Ala Tyr Ala Ser Leu His Val Thr 
1               5                   10                  15      


His His Asp Arg Pro Val Ala Trp Ala Leu Leu Pro Thr Ala 
            20                  25                  30  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Leu Ala Thr Arg Pro Gly Val Glu Pro Phe Thr Val Leu Arg Asn 
1               5                   10                  15  


<210>  25
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Ala Thr Val Gln Ala Val Arg Ser Ala Gly Ala Leu Leu Thr Lys Asp 
1               5                   10                  15      


Pro Thr Val Val Thr Thr Leu Ala Phe Trp Lys Pro Ala Thr Cys Gly 
            20                  25                  30          


Gly Val Ala Val Asn Arg Pro Ala Leu Val Gln Thr 
        35                  40                  


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Gln Met Glu Val Val Ile Val Glu Pro 
1               5                   


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Gly Ser Leu Thr Val Thr Ile 
1               5           


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Lys Thr Ala Asp Ser His Val Asp Val Ser Cys Glu Asn Ala Ala Gly 
1               5                   10                  15      


Thr Leu His Val Asp Thr 
            20          


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Gly Gly Gln Ser Val Arg Val Thr Leu Ala Arg Gln Val Thr Gln 
1               5                   10                  15  


