
                                SEQUENCE LISTING

<110> NGM BIOPHARMACEUTICALS, INC.

<120> BINDING PROTEINS AND METHODS OF USE THEREOF

<130> 13370-025-228

<140> TBA
<141> 2016-07-29

<150> 62/198,664          
<151> 2015-07-29  

<160> 313

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR1 - Exemplary

<400> 1
Gly Tyr Thr Phe Thr Glu Tyr Thr Met His
 1               5                  10  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR2 - Exemplary

<400> 2
Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 3
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR3 - Exemplary

<400> 3
Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val
 1               5                  10              


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR1 - Exemplary

<400> 4
Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn
 1               5                  10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR2 - Exemplary

<400> 5
Gly Ala Thr Ile Leu Ala Asp
 1               5          


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR3 - Exemplary

<400> 6
Gln Asn Val Leu Ser Thr Pro Tyr Thr
 1               5                  


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR1 - IMGT

<400> 7
Gly Tyr Thr Phe Thr Glu Tyr Thr
 1               5              


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR2 - IMGT

<400> 8
Phe Asn Pro Asp Ser Gly Gly Thr
 1               5              


<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR3 - IMGT

<400> 9
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val
 1               5                  10                  15  


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR1 - IMGT

<400> 10
Glu Asn Ile Tyr Gly Ala
 1               5      


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR2 - IMGT

<400> 11
Gly Ala Thr
 1          


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR1 - Kabat

<400> 12
Glu Tyr Thr Met His
 1               5  


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR2 - Kabat

<400> 13
Gly Ala Thr Asn Leu Ala Asp
 1               5          


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR1 - Chothia

<400> 14
Gly Tyr Thr Phe Thr Glu Tyr
 1               5          


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR2 - Chothia

<400> 15
Pro Asp Ser Gly
 1              


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR3 - Chothia

<400> 16
Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp
 1               5                  10      


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR1 - Chothia

<400> 17
Ser Glu Asn Ile Tyr Gly Ala
 1               5          


<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR3 - Chothia

<400> 18
Val Leu Ser Thr Pro Tyr
 1               5      


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR1 - Contact

<400> 19
Thr Glu Tyr Thr Met His
 1               5      


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR2 - Contact

<400> 20
Trp Ile Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser
 1               5                  10              


<210> 21
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR3 - Contact

<400> 21
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp
 1               5                  10                  


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR1 - Contact

<400> 22
Tyr Gly Ala Leu Asn Trp Tyr
 1               5          


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR2 - Contact

<400> 23
Leu Leu Ile Tyr Gly Ala Thr Asn Leu Ala
 1               5                  10  


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL CDR3 - Contact

<400> 24
Gln Asn Val Leu Ser Thr Pro Tyr
 1               5              


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH CDR2 - AbM

<400> 25
Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser
 1               5                  10  


<210> 26
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VH sequence

<400> 26
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 27
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 3I13 VL sequence

<400> 27
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR1 - Exemplary

<400> 28
Gly Tyr Thr Phe Thr Glu Tyr Ile Met Tyr
 1               5                  10  


<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR2 - Exemplary

<400> 29
Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR1 - IMGT

<400> 30
Gly Tyr Thr Phe Thr Glu Tyr Ile
 1               5              


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR2 - IMGT

<400> 31
Ile Asp Pro Asn Thr Gly Gly Thr
 1               5              


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR1 - Kabat

<400> 32
Glu Tyr Ile Met His
 1               5  


<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR2 - Chothia

<400> 33
Pro Asn Thr Gly
 1              


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR2 - AbM

<400> 34
Trp Ile Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser
 1               5                  10              


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR2 - Kabat

<400> 35
Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser
 1               5                  10  


<210> 36
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH sequence

<400> 36
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Ile Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ile Thr Ala Phe
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 37
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VL sequence

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR1 - Exemplary

<400> 38
Gly Tyr Thr Phe Thr Glu Tyr Thr Met Tyr
 1               5                  10  


<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - Exemplary

<400> 39
Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - IMGT

<400> 40
Phe Asn Pro Asn Tyr Gly Gly Ala
 1               5              


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR1 - Kabat

<400> 41
Glu Tyr Thr Met Tyr
 1               5  


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - Kabat

<400> 42
Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Asp
    


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - Chothia

<400> 43
Pro Asn Tyr Gly
 1              


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR1 - Contact

<400> 44
Thr Glu Tyr Thr Met Tyr
 1               5      


<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - Contact

<400> 45
Trp Ile Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser
 1               5                  10              


<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH CDR2 - AbM

<400> 46
Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser
 1               5                  10  


<210> 47
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VH sequence

<400> 47
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 48
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 4A2 VL sequence

<400> 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR1 of VH domain

<220> 
<221> VARIANT        
<222> 8, 10
<223> Xaa = Any Amino Acid

<400> 49
Gly Tyr Thr Phe Thr Glu Tyr Xaa Met Xaa
 1               5                  10  


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR2 of VH domain

<220> 
<221> VARIANT        
<222> 1, 2, 3, 5, 6, 9, 17
<223> Xaa = Any Amino Acid

<400> 50
Xaa Xaa Xaa Pro Xaa Xaa Gly Gly Xaa Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Xaa
    


<210> 51
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR3 of VH domain

<400> 51
Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val
 1               5                  10              


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR1 of VL domain

<400> 52
Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn
 1               5                  10      


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR2 of VL domain

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Any Amino Acid

<400> 53
Gly Ala Thr Xaa Leu Ala Asp
 1               5          


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus CDR3 of VL domain

<400> 54
Gln Asn Val Leu Ser Thr Pro Tyr Thr
 1               5                  


<210> 55
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m3I13 VH domain

<400> 55
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 56
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-a VH domain

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 57
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-b VH domain

<400> 57
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 58
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-c VH domain

<400> 58
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 59
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-d VH domain

<400> 59
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 60
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-e VH domain

<400> 60
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 61
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-f VH domain

<400> 61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 62
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-g VH domain

<400> 62
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 63
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-h VH domain

<400> 63
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 64
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-i VH domain

<400> 64
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 65
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-j VH domain

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 66
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-k VH domain

<400> 66
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 67
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-l VH domain

<400> 67
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 68
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-m VH domain

<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 69
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-n VH domain

<400> 69
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 70
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-o VH domain

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 71
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-p VH domain

<400> 71
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 72
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-q VH domain

<400> 72
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 73
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-r VH domain

<400> 73
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 74
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-s VH domain

<400> 74
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 75
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-t VH domain

<400> 75
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 76
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-u VH domain

<400> 76
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 77
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-v VH domain

<400> 77
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 78
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-HC-007-w VH domain

<400> 78
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 79
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m3I13 VL domain

<400> 79
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 80
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-a VL domain

<400> 80
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 81
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-b VL domain

<400> 81
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 82
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-c VL domain

<400> 82
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 83
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-d VL domain

<400> 83
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 84
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-e VL domain

<400> 84
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 85
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-f VL domain

<400> 85
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 86
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-g VL domain

<400> 86
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 87
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-h VL domain

<400> 87
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 88
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-i VL domain

<400> 88
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 89
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-j VL domain

<400> 89
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 90
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-k VL domain

<400> 90
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 91
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR1 of Humanized Anti-Beta Klotho Antibodies 

<400> 91
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 92
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 92
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 93
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 93
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 94
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 94
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 95
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 95
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 96
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody 2J21 VH CDR1 - Contact

<400> 96
Thr Glu Tyr Ile Met His
 1               5      


<210> 97
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 97
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
 1               5                  10      


<210> 98
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 98
Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu
 1               5                  10      


<210> 99
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 99
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
 1               5                  10      


<210> 100
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 100
Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu
 1               5                  10      


<210> 101
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 101
Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu
 1               5                  10      


<210> 102
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 102
Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu
 1               5                  10      


<210> 103
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain of antibody 2J21

<400> 103
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Ile Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ile Thr Ala Phe
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 104
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain of antibody 4A2

<400> 104
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 105
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain of antibody 3I13

<400> 105
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 106
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 106
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
 1               5                  10                  


<210> 107
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 107
Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met Gly
 1               5                  10                  


<210> 108
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 108
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly
 1               5                  10                  


<210> 109
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 109
Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met Gly
 1               5                  10                  


<210> 110
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 110
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 111
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 111
Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met Gly
 1               5                  10                  


<210> 112
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 112
Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Met Gly
 1               5                  10                  


<210> 113
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 113
Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 114
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain of antibody 2J21

<400> 114
Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 115
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain of antibody 4A2

<400> 115
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 116
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain of antibody 3I13

<400> 116
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 117
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 117
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 118
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 118
Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 119
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 119
Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 120
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 120
Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 121
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 121
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 122
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 122
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 123
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 123
Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 124
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-l VL domain

<400> 124
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 125
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 125
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 126
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 126
Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 127
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 127
Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 128
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 128
Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 129
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 129
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 130
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 130
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 131
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 131
Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 132
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-m VL domain

<400> 132
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 133
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR4 of Humanized Anti-Beta Klotho Antibodies

<400> 133
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 134
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-n VL domain

<400> 134
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 135
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 135
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys
            20              


<210> 136
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR1 of Humanized Anti-Beta Klotho Antibodies

<400> 136
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys
            20              


<210> 137
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-o VL domain

<400> 137
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 138
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 138
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
 1               5                  10      


<210> 139
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 139
Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
 1               5                  10      


<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 140
Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys
 1               5                  10      


<210> 141
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 141
Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys
 1               5                  10      


<210> 142
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 142
Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys
 1               5                  10      


<210> 143
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 143
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln
 1               5                  10      


<210> 144
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 144
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys
 1               5                  10      


<210> 145
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 145
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln
 1               5                  10      


<210> 146
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody 3I13-LC-007-p VL domain

<400> 146
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 147
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 147
Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 148
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 148
Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 149
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 149
Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 150
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 150
Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 151
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 151
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 152
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 152
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 153
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 153
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr
 1               5                  10                  15  


<210> 154
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 154
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 155
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 155
Gly Met Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 156
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 156
Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 157
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 157
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 158
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 158
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 159
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 159
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 160
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 160
Gly Met Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr
 1               5                  10                  15      
Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 161
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21 VL domain

<400> 161
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Ile Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ile Thr Ala Phe
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 162
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-a VH domain


<400> 162
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 163
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 163
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  10  


<210> 164
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-b VH domain

<400> 164
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 165
<211> 1044
<212> PRT
<213> Homo sapiens

<220> 
<223> human beta klotho sequence

<400> 165
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn
            20                  25                  30          
Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn
    50                  55                  60                  
Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His
            100                 105                 110         
Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser
                165                 170                 175     
Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln
305                 310                 315                 320 
Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu
            340                 345                 350         
Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp
        355                 360                 365             
Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr
    370                 375                 380                 
Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu
385                 390                 395                 400 
Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu
                405                 410                 415     
Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala
            420                 425                 430         
Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg
        435                 440                 445             
Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp
    450                 455                 460                 
Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr
465                 470                 475                 480 
Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala
                485                 490                 495     
His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu
            500                 505                 510         
Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly
        515                 520                 525             
Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln
    530                 535                 540                 
Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu
545                 550                 555                 560 
Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys
                565                 570                 575     
Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met
            580                 585                 590         
Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro
        595                 600                 605             
Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg
    610                 615                 620                 
Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr
625                 630                 635                 640 
Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu
                645                 650                 655     
His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala
            660                 665                 670         
Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp
        675                 680                 685             
Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser
    690                 695                 700                 
Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala
705                 710                 715                 720 
Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly
                725                 730                 735     
Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro
            740                 745                 750         
Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu
        755                 760                 765             
Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala
    770                 775                 780                 
Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser
785                 790                 795                 800 
Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly
                805                 810                 815     
Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met
            820                 825                 830         
His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln
        835                 840                 845             
Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val
    850                 855                 860                 
Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr
865                 870                 875                 880 
Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala
                885                 890                 895     
Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln
            900                 905                 910         
Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr
        915                 920                 925             
Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe
    930                 935                 940                 
Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys
945                 950                 955                 960 
Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys
                965                 970                 975     
Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val
            980                 985                 990         
Gln Lys Lys Pro Leu Ile Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu
        995                 1000                1005            
Val Leu Leu Leu Ser Ile Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys
    1010                1015                1020                
Phe Trp Lys Ala Lys Asn Leu Gln His Ile Pro Leu Lys Lys Gly Lys
1025                1030                1035                1040
Arg Val Val Ser
                


<210> 166
<211> 3132
<212> DNA
<213> Homo sapiens

<220> 
<223> human beta klotho

<400> 166
atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt cagcactgat 60
gaaataacca cacgctatag gaatacaatg tccaacgggg gattgcaaag atctgtcatc 120
ctgtcagcac ttattctgct acgagctgtt actggattct ctggagatgg aagagctata 180
tggtctaaaa atcctaattt tactccggta aatgaaagtc agctgtttct ctatgacact 240
ttccctaaaa actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300
aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca ccttaaaaat 360
gtcagcagca cgaatggttc cagtgacagt tatatttttc tggaaaaaga cttatcagcc 420
ctggatttta taggagtttc tttttatcaa ttttcaattt cctggccaag gcttttcccc 480
gatggaatag taacagttgc caacgcaaaa ggtctgcagt actacagtac tcttctggac 540
gctctagtgc ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600
gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat cttcaatgac 660
tatgccacat actgtttcca gatgtttggg gaccgtgtca aatattggat tacaattcac 720
aacccatatc tagtggcttg gcatgggtat gggacaggta tgcatgcccc tggagagaag 780
ggaaatttag cagctgtcta cactgtggga cacaacttga tcaaggctca ctcgaaagtt 840
tggcataact acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900
ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt caaatgtcaa 960
caatccatgg tttctgtgct tggatggttt gccaacccta tccatgggga tggcgactat 1020
ccagagggga tgagaaagaa gttgttctcc gttctaccca ttttctctga agcagagaag 1080
catgagatga gaggcacagc tgatttcttt gccttttctt ttggacccaa caacttcaag 1140
cccctaaaca ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200
aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa tggctggttc 1260
acagacagtc gtgtgaaaac agaagacacc acggccatct acatgatgaa gaatttcctc 1320
agccaggtgc ttcaagcaat aaggttagat gaaatacgag tgtttggtta tactgcctgg 1380
tctctcctgg atggctttga atggcaggat gcttacacca tccgccgagg attattttat 1440
gtggatttta acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500
cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt gcagggccag 1560
tttccctgtg acttctcctg gggtgtcact gaatctgttc ttaagcccga gtctgtggct 1620
tcgtccccac agttcagcga tcctcatctg tacgtgtgga acgccactgg caacagactg 1680
ttgcaccgag tggaaggggt gaggctgaaa acacgacccg ctcaatgcac agattttgta 1740
aacatcaaaa aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800
ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg acaggccctg 1860
aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg gcatctccgc gatggtcacc 1920
ctgtattatc cgacccacgc ccacctaggc ctccccgagc ctctgttgca tgccgacggg 1980
tggctgaacc catcgacggc cgaggccttc caggcctacg ctgggctgtg cttccaggag 2040
ctgggggacc tggtgaagct ctggatcacc atcaacgagc ctaaccggct aagtgacatc 2100
tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt ggcccacgcc 2160
ctggcctggc gcctctacga ccggcagttc aggccctcac agcgcggggc cgtgtcgctg 2220
tcgctgcacg cggactgggc ggaacccgcc aacccctatg ctgactcgca ctggagggcg 2280
gccgagcgct tcctgcagtt cgagatcgcc tggttcgccg agccgctctt caagaccggg 2340
gactaccccg cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400
tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac ggtcgacttc 2460
tgcgcgctca accacttcac cactaggttc gtgatgcacg agcagctggc cggcagccgc 2520
tacgactcgg acagggacat ccagtttctg caggacatca cccgcctgag ctcccccacg 2580
cgcctggctg tgattccctg gggggtgcgc aagctgctgc ggtgggtccg gaggaactac 2640
ggcgacatgg acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700
cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc atacctgatt 2760
gataaagtca gaatcaaagg ctattatgca ttcaaactgg ctgaagagaa atctaaaccc 2820
agatttggat tcttcacatc tgattttaaa gctaaatcct caatacaatt ttacaacaaa 2880
gtgatcagca gcaggggctt cccttttgag aacagtagtt ctagatgcag tcagacccaa 2940
gaaaatacag agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg 3000
ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt tcaaaggcag 3060
aagagaagaa agttttggaa agcaaaaaac ttacaacaca taccattaaa gaaaggcaag 3120
agagttgtta gc                                                     3132

<210> 167
<211> 1044
<212> PRT
<213> Macaca fascicularis (cynomolgus monkey)

<220> 
<223> cyno beta klotho

<400> 167
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Phe Ser Thr Asp Glu Ile Thr Ile Arg Tyr Arg Asn Thr Met Ser Asn
            20                  25                  30          
Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Thr Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Val Trp Ser Lys Asn
    50                  55                  60                  
Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Val Gly Thr Gly Ala Leu Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His
            100                 105                 110         
Phe Val His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Asn
                165                 170                 175     
Thr Leu Leu Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Leu Lys Cys Gln
305                 310                 315                 320 
Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Gly Met Lys Lys Lys Leu Leu Ser Ile Leu
            340                 345                 350         
Pro Leu Phe Ser Glu Ala Glu Lys Asn Glu Val Arg Gly Thr Ala Asp
        355                 360                 365             
Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr
    370                 375                 380                 
Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu
385                 390                 395                 400 
Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu
                405                 410                 415     
Asn Gly Trp Phe Thr Asp Ser His Val Lys Thr Glu Asp Thr Thr Ala
            420                 425                 430         
Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg
        435                 440                 445             
Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp
    450                 455                 460                 
Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr
465                 470                 475                 480 
Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala
                485                 490                 495     
His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu
            500                 505                 510         
Ala Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly
        515                 520                 525             
Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln
    530                 535                 540                 
Phe Ser Asp Pro Tyr Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu
545                 550                 555                 560 
Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys
                565                 570                 575     
Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met
            580                 585                 590         
Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro
        595                 600                 605             
Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg
    610                 615                 620                 
Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr
625                 630                 635                 640 
Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu
                645                 650                 655     
His Ala Gly Gly Trp Leu Asn Pro Ser Thr Val Glu Ala Phe Gln Ala
            660                 665                 670         
Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp
        675                 680                 685             
Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser
    690                 695                 700                 
Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala
705                 710                 715                 720 
Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly
                725                 730                 735     
Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro
            740                 745                 750         
Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu
        755                 760                 765             
Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala
    770                 775                 780                 
Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser
785                 790                 795                 800 
Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly
                805                 810                 815     
Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met
            820                 825                 830         
His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln
        835                 840                 845             
Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val
    850                 855                 860                 
Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr
865                 870                 875                 880 
Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala
                885                 890                 895     
Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Glu Lys Tyr Leu Gln
            900                 905                 910         
Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr
        915                 920                 925             
Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe
    930                 935                 940                 
Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys
945                 950                 955                 960 
Met Ile Ser Ser Ser Gly Phe Pro Ser Glu Asn Ser Ser Ser Arg Cys
                965                 970                 975     
Ser Gln Thr Gln Lys Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val
            980                 985                 990         
Gln Lys Lys Pro Leu Ile Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu
        995                 1000                1005            
Val Leu Leu Leu Ser Ile Thr Ile Phe His Arg Gln Lys Arg Arg Lys
    1010                1015                1020                
Phe Trp Lys Ala Lys Asn Leu Gln His Ile Pro Leu Lys Lys Gly Lys
1025                1030                1035                1040
Arg Val Leu Ser
                


<210> 168
<211> 3135
<212> DNA
<213> Macaca fascicularis (cynomolgus monkey)

<220> 
<223> cyno beta klotho 

<400> 168
atgaagcctg gatgtgccgc cggaagcccc ggcaacgagt ggatcttctt cagcaccgac 60
gagatcacca tccggtacag aaacaccatg agcaacggcg gcctgcagcg gagcgtgatc 120
ctgtctgctc tgaccctgct gagagccgtg accggcttca gcggagatgg cagagccgtg 180
tggtccaaga accccaactt cacccccgtg aacgagagcc agctgttcct gtacgatacc 240
ttccccaaga acttcttctg gggcgtgggc acaggcgccc tgcaggtgga aggatcctgg 300
aagaaggacg gcaagggccc cagcatctgg gaccactttg tgcacaccca cctgaagaac 360
gtgtccagca ccaacggcag cagcgacagc tacatctttc tggaaaagga cctgagcgcc 420
ctggacttca tcggcgtgtc cttctaccag ttcagcatca gctggcccag actgttcccc 480
gacggcatcg tgacagtggc caatgccaag ggcctgcagt actacaacac cctgctggac 540
agcctggtgc tgcggaacat cgagcccatc gtgaccctgt accactggga cctgccactg 600
gctctgcagg agaaatacgg cggctggaag aacgacacca tcatcgacat cttcaacgac 660
tacgccacct actgcttcca gaccttcggc gacagagtga agtactggat cacaatccac 720
aacccctacc tggtggcctg gcacggctat ggcaccggaa tgcatgcccc tggcgagaag 780
ggaaatctgg ccgccgtgta caccgtgggc cacaacctga tcaaggccca cagcaaagtg 840
tggcacaact acaataccca cttccggccc caccagaagg gctggctgtc tatcacactg 900
ggcagccact ggatcgagcc taaccgcagc gagaacacca tggacatcct gaagtgccag 960
cagagcatgg tgtccgtgct gggatggttc gccaacccca ttcacggcga cggcgattac 1020
cccgagggca tgaagaagaa gctgctgagc atcctgcccc tgttcagcga ggccgagaag 1080
aacgaagtgc ggggcaccgc cgatttcttc gcctttagct tcggccccaa caacttcaag 1140
cccctgaata ccatggccaa gatgggccag aatgtgtccc tgaacctgag agaggccctg 1200
aactggatca agctggagta caacaacccc cggatcctga tcgccgagaa cggctggttc 1260
accgacagcc acgtgaaaac cgaggacacc accgccatct atatgatgaa gaacttcctg 1320
agccaggtgc tgcaggctat ccggctggat gagatccggg tgttcggcta caccgcctgg 1380
tcactgctgg acggcttcga atggcaggac gcctacacca tcagacgggg cctgttctac 1440
gtggacttca acagcaagca gaaagagcgg aagcccaaga gcagcgccca ctactacaag 1500
cagatcatca gagagaatgg cttcagcctg aaagaggcca cccccgacgt gcagggccag 1560
ttcccttgtg atttctcttg gggcgtgacc gagagcgtgc tgaagcctga aagcgtggcc 1620
agcagccccc agttcagcga cccttacctg tacgtgtgga acgccaccgg caaccggctg 1680
ctgcatagag tggaaggcgt gcggctgaaa accagacccg cccagtgcac cgacttcgtg 1740
aacatcaaga aacagctgga aatgctggcc cggatgaaag tgacccacta cagattcgcc 1800
ctggactggg ccagcgtgct gcctaccgga aatctgagcg ccgtgaacag acaggccctg 1860
cggtactaca gatgcgtggt gtccgagggc ctgaagctgg gcatcagcgc catggtcacc 1920
ctgtactacc ctacccacgc ccacctggga ctgcctgaac ctctgctgca tgctggcggc 1980
tggctgaacc ctagcaccgt ggaagccttt caggcctacg ccgggctgtg cttccaggaa 2040
ctgggcgacc tcgtgaagct gtggatcacc atcaacgagc ccaacagact gagcgacatc 2100
tacaacagaa gcggcaacga cacctacggc gctgcccaca atctgctggt ggctcatgcc 2160
ctggcttggc ggctgtacga cagacagttc cggccttctc agcggggagc cgtgtctctg 2220
tctctgcatg ccgattgggc cgagcccgcc aacccttacg ccgactctca ttggagagcc 2280
gccgagcggt tcctgcagtt cgagatcgct tggtttgccg agcccctgtt caagaccggc 2340
gattaccctg ccgccatgag agagtatatc gccagcaagc acagacgggg cctgagcagc 2400
tctgccctgc ctagactgac cgaggccgag cggagactgc tgaagggaac cgtggatttc 2460
tgcgccctga accacttcac caccagattc gtgatgcacg agcagctggc cggcagcaga 2520
tacgacagcg accgggacat ccagtttctg caggacatca cccggctgag cagccctaca 2580
agactggccg tgatcccttg gggagtgcgg aagctgctga gatgggtgcg cagaaactac 2640
ggcgacatgg atatctacat caccgccagc ggcatcgacg accaggccct ggaagatgac 2700
cggctgcgga agtactacct ggaaaagtac ctgcaggaag tgctgaaggc ctacctgatc 2760
gacaaagtgc ggatcaaggg ctactacgcc ttcaagctgg ccgaggaaaa gagcaagccc 2820
agattcggct tcttcaccag cgacttcaag gccaagagca gcatccagtt ctacaacaag 2880
atgatcagca gcagcggctt ccccagcgag aacagcagct ccagatgcag ccagacccag 2940
aaaaacaccg agtgtaccgt gtgcctgttc ctggtgcaga agaagcccct gatcttcctg 3000
ggctgctgct tctttagcac cctggtgctg ctgctgtcca tcaccatctt ccaccggcag 3060
aagcggagaa agttctggaa ggccaaaaac ctgcagcaca tccccctgaa gaaaggcaag 3120
cgggtgctga gctga                                                  3135

<210> 169
<211> 1043
<212> PRT
<213> Mus musculus

<220> 
<223> mouse beta klotho homolog 

<400> 169
Met Lys Thr Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Phe Ser Ser Asp Glu Arg Asn Thr Arg Ser Arg Lys Thr Met Ser Asn
            20                  25                  30          
Arg Ala Leu Gln Arg Ser Ala Val Leu Ser Ala Phe Val Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys
    50                  55                  60                  
Gln Tyr Val Ser Pro Val Asn Pro Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Thr Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg
            100                 105                 110         
Tyr Val Tyr Ser His Leu Arg Gly Val Asn Gly Thr Asp Arg Ser Thr
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asn Gly Thr Val Ala Ala Val Asn Ala Gln Gly Leu Arg Tyr Tyr Arg
                165                 170                 175     
Ala Leu Leu Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Thr Asp Asn Met Glu Asp Val Ile Asn Cys Gln
305                 310                 315                 320 
His Ser Met Ser Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Phe Met Lys Thr Gly Ala Met Ile Pro Glu
            340                 345                 350         
Phe Ser Glu Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe
        355                 360                 365             
Ala Phe Ser Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val
    370                 375                 380                 
Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp
385                 390                 395                 400 
Ile Lys Leu Glu Tyr Asp Asp Pro Gln Ile Leu Ile Ser Glu Asn Gly
                405                 410                 415     
Trp Phe Thr Asp Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr
            420                 425                 430         
Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp
        435                 440                 445             
Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe
    450                 455                 460                 
Glu Trp Gln Asp Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp
465                 470                 475                 480 
Phe Asn Ser Glu Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr
                485                 490                 495     
Tyr Lys Gln Ile Ile Gln Asp Asn Gly Phe Pro Leu Lys Glu Ser Thr
            500                 505                 510         
Pro Asp Met Lys Gly Arg Phe Pro Cys Asp Phe Ser Trp Gly Val Thr
        515                 520                 525             
Glu Ser Val Leu Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr
    530                 535                 540                 
Asp Pro His Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr
545                 550                 555                 560 
Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp
                565                 570                 575     
Tyr Val Ser Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val
            580                 585                 590         
Thr His Tyr Gln Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly
        595                 600                 605             
Asn Leu Ser Lys Val Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val
    610                 615                 620                 
Val Ser Glu Gly Leu Lys Leu Gly Val Phe Pro Met Val Thr Leu Tyr
625                 630                 635                 640 
His Pro Thr His Ser His Leu Gly Leu Pro Leu Pro Leu Leu Ser Ser
                645                 650                 655     
Gly Gly Trp Leu Asn Met Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala
            660                 665                 670         
Glu Leu Cys Phe Arg Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr
        675                 680                 685             
Ile Asn Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn
    690                 695                 700                 
Asp Thr Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val
705                 710                 715                 720 
Trp His Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val
                725                 730                 735     
Ser Leu Ser Leu His Cys Asp Trp Ala Glu Pro Ala Asn Pro Phe Val
            740                 745                 750         
Asp Ser His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala
        755                 760                 765             
Trp Phe Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ser Val Met
    770                 775                 780                 
Lys Glu Tyr Ile Ala Ser Lys Asn Gln Arg Gly Leu Ser Ser Ser Val
785                 790                 795                 800 
Leu Pro Arg Phe Thr Ala Lys Glu Ser Arg Leu Val Lys Gly Thr Val
                805                 810                 815     
Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys
            820                 825                 830         
Gln Leu Asn Thr Asn Arg Ser Val Ala Asp Arg Asp Val Gln Phe Leu
        835                 840                 845             
Gln Asp Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro
    850                 855                 860                 
Trp Gly Val Arg Lys Leu Leu Ala Trp Ile Arg Arg Asn Tyr Arg Asp
865                 870                 875                 880 
Arg Asp Ile Tyr Ile Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu
                885                 890                 895     
Asp Asp Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala
            900                 905                 910         
Leu Lys Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala
        915                 920                 925             
Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr
    930                 935                 940                 
Ser Asp Phe Arg Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile
945                 950                 955                 960 
Ser Ser Ser Gly Leu Pro Ala Glu Asn Arg Ser Pro Ala Cys Gly Gln
                965                 970                 975     
Pro Ala Glu Asp Thr Asp Cys Thr Ile Cys Ser Phe Leu Val Glu Lys
            980                 985                 990         
Lys Pro Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Val
        995                 1000                1005            
Leu Leu Ser Ile Thr Val Phe His His Gln Lys Arg Arg Lys Phe Gln
    1010                1015                1020                
Lys Ala Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg
1025                1030                1035                1040
Val Phe Ser
            


<210> 170
<211> 3129
<212> DNA
<213> Mus musculus

<220> 
<223> mouse beta klotho homolog 

<400> 170
atgaagacag gctgtgcagc agggtctccg gggaatgaat ggattttctt cagctctgat 60
gaaagaaaca cacgctctag gaaaacaatg tccaacaggg cactgcaaag atctgccgtg 120
ctgtctgcgt ttgttctgct gcgagctgtt accggcttct ccggagacgg gaaagcaata 180
tgggataaaa aacagtacgt gagtccggta aacccaagtc agctgttcct ctatgacact 240
ttccctaaaa acttttcctg gggcgttggg accggagcat ttcaagtgga agggagttgg 300
aagacagatg gaagaggacc ctcgatctgg gatcggtacg tctactcaca cctgagaggt 360
gtcaacggca cagacagatc cactgacagt tacatctttc tggaaaaaga cttgttggct 420
ctggattttt taggagtttc tttttatcag ttctcaatct cctggccacg gttgtttccc 480
aatggaacag tagcagcagt gaatgcgcaa ggtctccggt actaccgtgc acttctggac 540
tcgctggtac ttaggaatat cgagcccatt gttaccttgt accattggga tttgcctctg 600
acgctccagg aagaatatgg gggctggaaa aatgcaacta tgatagatct cttcaacgac 660
tatgccacat actgcttcca gacctttgga gaccgtgtca aatattggat tacaattcac 720
aacccttacc ttgttgcttg gcatgggttt ggcacaggta tgcatgcacc aggagagaag 780
ggaaatttaa cagctgtcta cactgtggga cacaacctga tcaaggcaca ttcgaaagtg 840
tggcataact acgacaaaaa cttccgccct catcagaagg gttggctctc catcaccttg 900
gggtcccatt ggatagagcc aaacagaaca gacaacatgg aggacgtgat caactgccag 960
cactccatgt cctctgtgct tggatggttc gccaacccca tccacgggga cggcgactac 1020
cctgagttca tgaagacggg cgccatgatc cccgagttct ctgaggcaga gaaggaggag 1080
gtgaggggca cggctgattt ctttgccttt tccttcgggc ccaacaactt caggccctca 1140
aacaccgtgg tgaaaatggg acaaaatgta tcactcaact taaggcaggt gctgaactgg 1200
attaaactgg aatacgatga ccctcaaatc ttgatttcgg agaacggctg gttcacagat 1260
agctatataa agacagagga caccacggcc atctacatga tgaagaattt cctaaaccag 1320
gttcttcaag caataaaatt tgatgaaatc cgcgtgtttg gttatacggc ctggactctc 1380
ctggatggct ttgagtggca ggatgcctat acgacccgac gagggctgtt ttatgtggac 1440
tttaacagtg agcagaaaga gaggaaaccc aagtcctcgg ctcattacta caagcagatc 1500
atacaagaca acggcttccc tttgaaagag tccacgccag acatgaaggg tcggttcccc 1560
tgtgatttct cttggggagt cactgagtct gttcttaagc ccgagtttac ggtctcctcc 1620
ccgcagttta ccgatcctca cctgtatgtg tggaatgtca ctggcaacag attgctctac 1680
cgagtggaag gggtaaggct gaaaacaaga ccatcccagt gcacagatta tgtgagcatc 1740
aaaaaacgag ttgaaatgtt ggcaaaaatg aaagtcaccc actaccagtt tgctctggac 1800
tggacctcta tccttcccac tggcaatctg tccaaagtta acagacaagt gttaaggtac 1860
tataggtgtg tggtgagcga aggactgaag ctgggcgtct tccccatggt gacgttgtac 1920
cacccaaccc actcccatct cggcctcccc ctgccacttc tgagcagtgg ggggtggcta 1980
aacatgaaca cagccaaggc cttccaggac tacgctgagc tgtgcttccg ggagttgggg 2040
gacttggtga agctctggat caccatcaat gagcctaaca ggctgagtga catgtacaac 2100
cgcacgagta atgacaccta ccgtgcagcc cacaacctga tgatcgccca tgcccaggtc 2160
tggcacctct atgataggca gtataggccg gtccagcatg gggctgtgtc gctgtcctta 2220
cattgcgact gggcagaacc tgccaacccc tttgtggatt cacactggaa ggcagccgag 2280
cgcttcctcc agtttgagat cgcctggttt gcagatccgc tcttcaagac tggcgactat 2340
ccatcggtta tgaaggaata catcgcctcc aagaaccagc gagggctgtc tagctcagtc 2400
ctgccgcgct tcaccgcgaa ggagagcagg ctggtgaagg gtaccgtcga cttctacgca 2460
ctgaaccact tcactacgag gttcgtgata cacaagcagc tgaacaccaa ccgctcagtt 2520
gcagacaggg acgtccagtt cctgcaggac atcacccgcc taagctcgcc cagccgcctg 2580
gctgtaacac cctggggagt gcgcaagctc cttgcgtgga tccggaggaa ctacagagac 2640
agggatatct acatcacagc caatggcatc gatgacctgg ctctagagga tgatcagatc 2700
cgaaagtact acttggagaa gtatgtccag gaggctctga aagcatatct cattgacaag 2760
gtcaaaatca aaggctacta tgcattcaaa ctgactgaag agaaatctaa gcctagattt 2820
ggatttttca cctctgactt cagagctaag tcctctgtcc agttttacag caagctgatc 2880
agcagcagtg gcctccccgc tgagaacaga agtcctgcgt gtggtcagcc tgcggaagac 2940
acagactgca ccatttgctc atttctcgtg gagaagaaac cactcatctt cttcggttgc 3000
tgcttcatct ccactctggc tgtactgcta tccatcaccg tttttcatca tcaaaagaga 3060
agaaaattcc agaaagcaag gaacttacaa aatataccat tgaagaaagg ccacagcaga 3120
gttttcagc                                                         3129

<210> 171
<211> 1043
<212> PRT
<213> Rattus norvegicus

<220> 
<223> rat beta klotho

<400> 171
Met Lys Thr Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Val Phe
 1               5                  10                  15      
Phe Ser Ser Asp Glu Arg Ser Thr Arg Ser Arg Lys Thr Met Ser Asn
            20                  25                  30          
Gly Ala Leu Gln Arg Ser Ala Val Leu Ser Ala Leu Val Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys
    50                  55                  60                  
Gln Tyr Val Ser Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg
            100                 105                 110         
Tyr Val Asp Ser His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr
        115                 120                 125             
Asp Ser Tyr Val Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asn Gly Thr Val Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg
                165                 170                 175     
Ala Leu Leu Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln
305                 310                 315                 320 
His Ser Met Ser Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu
            340                 345                 350         
Phe Ser Glu Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe
        355                 360                 365             
Ala Phe Ser Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val
    370                 375                 380                 
Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp
385                 390                 395                 400 
Ile Lys Leu Glu Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly
                405                 410                 415     
Trp Phe Thr Asp Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr
            420                 425                 430         
Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp
        435                 440                 445             
Glu Ile Gln Val Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe
    450                 455                 460                 
Glu Trp Gln Asp Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp
465                 470                 475                 480 
Phe Asn Ser Glu Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr
                485                 490                 495     
Tyr Lys Gln Ile Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr
            500                 505                 510         
Pro Asp Met Lys Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr
        515                 520                 525             
Glu Ser Val Leu Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr
    530                 535                 540                 
Asp Pro His Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr
545                 550                 555                 560 
Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp
                565                 570                 575     
Tyr Val Ser Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val
            580                 585                 590         
Thr His Tyr Gln Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly
        595                 600                 605             
Asn Leu Ser Lys Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val
    610                 615                 620                 
Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr
625                 630                 635                 640 
His Pro Thr His Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser
                645                 650                 655     
Gly Gly Trp Leu Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala
            660                 665                 670         
Gly Leu Cys Phe Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr
        675                 680                 685             
Ile Asn Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn
    690                 695                 700                 
Asp Thr Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val
705                 710                 715                 720 
Trp His Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val
                725                 730                 735     
Ser Leu Ser Leu His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val
            740                 745                 750         
Glu Ser His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala
        755                 760                 765             
Trp Phe Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met
    770                 775                 780                 
Lys Glu Tyr Ile Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val
785                 790                 795                 800 
Leu Pro Arg Phe Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile
                805                 810                 815     
Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys
            820                 825                 830         
Gln Leu Asn Thr Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu
        835                 840                 845             
Gln Asp Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro
    850                 855                 860                 
Trp Gly Met Arg Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp
865                 870                 875                 880 
Met Asp Ile Tyr Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu
                885                 890                 895     
Asp Asp Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala
            900                 905                 910         
Leu Lys Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala
        915                 920                 925             
Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr
    930                 935                 940                 
Ser Asp Phe Lys Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile
945                 950                 955                 960 
Ser Ser Ser Gly Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln
                965                 970                 975     
Pro Pro Glu Asp Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys
            980                 985                 990         
Lys Pro Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala
        995                 1000                1005            
Leu Leu Ser Ile Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln
    1010                1015                1020                
Lys Ala Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg
1025                1030                1035                1040
Val Phe Ser
            


<210> 172
<211> 3132
<212> DNA
<213> Rattus norvegicus

<220> 
<223> rat beta klotho

<400> 172
atgaagacag gctgtgcagc agggtctcca gggaatgaat gggttttctt cagctctgat 60
gaaagaagca cacgctctag gaaaacaatg tccaacggag cactgcaaag atctgccgtg 120
ctgtctgcat tggttctgct gcgagctgtt accggcttct ctggagacgg aaaagcaata 180
tgggataaaa aacaatacgt gagtccggta aacccaggtc agctgttcct ctatgacact 240
ttccctaaaa acttttcctg gggcgttggg accggagcat ttcaagtgga agggagttgg 300
aaggcagatg gaagaggacc ctcgatctgg gaccgttatg tcgactcaca cctgagaggt 360
gtcaacagca cagacagatc cactgacagt tatgtctttc tggaaaagga cttgctggct 420
ctggattttt taggagtttc tttttatcag ttctcaatct cctggccgcg gttgttcccc 480
aacggaacag tagcagctgt gaatgcaaaa ggtctccagt actacagagc acttctggac 540
tcgctggtac ttaggaatat cgaacccatt gttaccttat accattggga tttgcctttg 600
acgctacagg aagaatatgg gggctggaaa aatgcaacta tgatagatct cttcaatgac 660
tatgccacat actgcttcca gacctttgga gaccgtgtca aatattggat tacaattcac 720
aacccttacc tcgttgcttg gcatgggttt ggcacaggta tgcatgcgcc aggagagaag 780
ggaaatttaa cagctgtcta cactgtggga cacaacctga tcaaggcgca ttcgaaagtg 840
tggcataact acgacaaaaa cttccgccct catcagaagg gttggctctc catcaccttg 900
gggtcccatt ggatagaacc aaacagaaca gaaaacatgg aggacgtgat caactgccag 960
cactccatgt cttctgtgct cggatggttt gccaacccca tccacggaga cggcgactac 1020
cccgagttca tgaagacgag ctccgtaatc cctgagttct ctgaggcaga gaaggaggag 1080
gtgcggggca ctgctgactt ctttgccttt tccttcgggc ccaacaattt caggccctcg 1140
aacaccgtgg taaaaatggg acaaaatgta tcactcaact taagacaggt gctgaactgg 1200
attaaactag aatatgacaa ccctcgaatc ttgatttcgg agaacggctg gttcacagat 1260
agttatataa agacggaaga taccacggcc atctacatga tgaagaattt cctcaaccag 1320
gttcttcaag caataaagtt tgatgaaata caagtgtttg gttatacggc ttggactctc 1380
ctggatggct ttgagtggca ggatgcctac acgacccgac gagggctgtt ttatgtggac 1440
tttaatagtg agcagaaaga gaggaaaccc aagtcctccg ctcattacta caaacagatt 1500
atacaagaca acggtttccc tttgcaagaa tccacaccag acatgaaggg tcagtttccc 1560
tgtgacttct cctggggagt cactgagtct gttcttaagc cggagtttac ggtgtcctcc 1620
ccacagttta ctgatcctca cctgtatgtg tggaatgtca ctggcaacag attgctatac 1680
cgagtggaag gagtcaggct aaaaacaaga ccgtcccaat gcacagatta tgtgagcatc 1740
aaaaaacgag ttgaaatgtt ggccaaaatg aaagtcaccc actaccagtt tgctctggac 1800
tggacctcta tcctccctac cggaaatctg tctaaaatta atagacaagt gttgaggtac 1860
tataggtgtg tggtgagcga aggactgaag ctgggcatct cccctatggt gacgttgtac 1920
cacccgaccc actcccatct aggcctcccc atgccacttc tgagcagtgg gggatggcta 1980
aacaccaaca cagccaaggc cttccaggac tacgcaggcc tgtgcttcaa ggagctgggg 2040
gacttggtaa agctctggat caccatcaat gaacccaata ggctgagtga catgtacaac 2100
cgcacgagta acgacaccta ccgtgcggcc cacaacctga tgatcgccca tgcccaggtc 2160
tggcacctct atgataggca gtataggccg gtccagcacg gggctgtgtc gctgtcctta 2220
cattccgact gggcagaacc tgccaacccc tatgtggagt ctcactggaa ggcagccgag 2280
cgcttcctcc agtttgagat cgcctggttt gcggatccac tcttcaagac tggtgactac 2340
ccgctggcca tgaaggaata catcgcctcc aagaagcagc gagggctgtc tagctcagtc 2400
ctgccgcgct ttaccttgaa ggagagcagg ctggtgaagg ggaccatcga cttttacgca 2460
ctgaaccact tcactactag attcgtgata cacaagcagt tgaataccaa ctgctcagtg 2520
gcagacaggg acgtccagtt cctgcaggac atcacccgcc tgagctcgcc cagtcgccta 2580
gccgtaacgc cctggggaat gcgcaagctc cttgggtgga tccggaggaa ctacagagac 2640
atggatatct acgtcacagc caatggcatt gatgatcttg ctctagagga cgatcagatt 2700
agaaagtact acttggagaa gtacgtccag gaggctctga aagcatatct gattgacaag 2760
gtcaaaatca aaggctacta tgcattcaaa ctgactgaag agaaatctaa gcctagattt 2820
ggatttttca catctgactt caaagctaaa tcttctgtac agttttatag caagctgatc 2880
agcagcagcg gcttctcctc tgagaacaga agtcctgcct gtggtcagcc tccagaagac 2940
acagaatgcg ccatttgctc cttccttaca cagaagaaac cactcatctt ctttggttgt 3000
tgcttcatct ccactctggc tgcactgcta tcaatcacta tttttcatca tcggaagaga 3060
agaaaattcc agaaagcaag gaacttacaa aatataccat tgaagaaagg gcacagcaga 3120
gtttttagct aa                                                     3132

<210> 173
<211> 1042
<212> PRT
<213> Cricetulus griseus

<220> 
<223> Hamster beta klotho

<400> 173
Met Lys Ala Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Leu Ser Ser Tyr Glu Arg Asn Thr Arg Ser Lys Lys Thr Met Ser Asn
            20                  25                  30          
Arg Ala Leu Gln Arg Ser Val Val Leu Ser Ala Phe Val Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Leu Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys
    50                  55                  60                  
Gln Tyr Val Ser Pro Val Asn Ala Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Asn Trp Gln Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg
            100                 105                 110         
Phe Ile Tyr Thr His Leu Arg Asp Val Ser Ile Thr Glu Lys Ser Ala
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asn Gly Thr Val Ala Ser Val Asn Ala Lys Gly Leu Gln Tyr Tyr Asn
                165                 170                 175     
Lys Leu Leu Asp Ser Leu Ile Leu Arg Asn Ile Glu Pro Val Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Asp Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Phe Ala Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Thr Gly Asn Leu Thr Ala Val Tyr Ile Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Leu Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Lys Thr Glu Asn Met Ala Asp Thr Ile Ser Cys Gln
305                 310                 315                 320 
His Ser Met Ala Phe Val Leu Gly Trp Phe Ala Asn Pro Ile His Ala
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Phe Met Lys Thr Leu Ser Thr Met Pro Val
            340                 345                 350         
Phe Ser Glu Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe
        355                 360                 365             
Ala Phe Ser Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val
    370                 375                 380                 
Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp
385                 390                 395                 400 
Ile Lys Leu Glu Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly
                405                 410                 415     
Trp Phe Thr Asp Ser Asp Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr
            420                 425                 430         
Met Met Lys His Phe Leu Asn Gln Val Leu Gln Ala Ile Gln Phe Asp
        435                 440                 445             
Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe
    450                 455                 460                 
Glu Trp Gln Tyr Ala Tyr Thr Ser Arg Arg Gly Leu Phe Tyr Val Asp
465                 470                 475                 480 
Phe Asn Ser Glu Gln Lys Glu Arg Lys Pro Lys Thr Ser Ala His Tyr
                485                 490                 495     
Tyr Lys Gln Ile Ile Gln Glu Asn Gly Phe Pro Leu Lys Glu Ser Thr
            500                 505                 510         
Pro Asp Met Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr
        515                 520                 525             
Glu Ser Val Leu Lys Pro Glu Phe Met Val Ser Ser Pro Gln Phe Thr
    530                 535                 540                 
Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu Gln
545                 550                 555                 560 
Arg Val Glu Gly Val Arg Leu Lys Thr Lys Pro Ser His Cys Thr Asp
                565                 570                 575     
Tyr Val Ser Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val
            580                 585                 590         
Thr His Tyr Gln Phe Ala Leu Asp Trp Ala Thr Ile Leu Pro Thr Gly
        595                 600                 605             
Asn Leu Ser Glu Val Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val
    610                 615                 620                 
Val Ser Glu Gly Leu Lys Leu Gly Val Ser Pro Met Val Thr Leu Tyr
625                 630                 635                 640 
His Pro Thr His Ser His Leu Gly Leu Pro Glu Pro Leu Leu Asn Ser
                645                 650                 655     
Gly Gly Trp Leu Asn Thr Tyr Thr Ala Lys Ala Phe Gln Asp Tyr Ala
            660                 665                 670         
Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr
        675                 680                 685             
Ile Asn Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn
    690                 695                 700                 
Asp Thr Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val
705                 710                 715                 720 
Trp Arg Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val
                725                 730                 735     
Ser Leu Ser Leu His Ser Asp Trp Val Glu Pro Ala Asn Pro Tyr Val
            740                 745                 750         
Asp Ser His Trp Lys Ala Ala Glu Arg Phe Leu Leu Phe Glu Ile Ala
        755                 760                 765             
Trp Phe Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met
    770                 775                 780                 
Lys Glu Tyr Ile Ala Ser Lys Asn Gln Gln Gly Leu Ser Arg Ser Val
785                 790                 795                 800 
Leu Pro Arg Phe Thr Pro Glu Glu Ser Arg Leu Val Lys Gly Thr Ile
                805                 810                 815     
Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys
            820                 825                 830         
Gln Leu Asn Ser Ser Arg Ser Met Ala Asp Arg Asp Val Gln Phe Leu
        835                 840                 845             
Gln Asp Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Met Pro
    850                 855                 860                 
Trp Gly Ala Arg Lys Leu Leu Gly Trp Ile Gln Arg Asn Tyr Gly Asp
865                 870                 875                 880 
Met Asp Ile Tyr Ile Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu
                885                 890                 895     
Asn Asp Gly Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Ile Gln Glu Ala
            900                 905                 910         
Leu Lys Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala
        915                 920                 925             
Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr
    930                 935                 940                 
Ser Asp Phe Lys Ala Lys Ser Ser Val Glu Phe Tyr Ser Lys Leu Ile
945                 950                 955                 960 
Ser Arg Ser Gly Phe Pro Ser Glu Thr Ser Asn Pro Ala Cys Gly Gln
                965                 970                 975     
Pro Pro Glu Asp Thr Asp Cys Thr Ile Cys Ser Phe Phe Thr Gln Lys
            980                 985                 990         
Lys Ser Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Val
        995                 1000                1005            
Leu Leu Ser Ile Thr Ile Phe His His Arg Lys Arg Arg Phe His Lys
    1010                1015                1020                
Ser Lys Asn Leu Glu Asn Ile Pro Leu Lys Glu Gly His Ser Arg Val
1025                1030                1035                1040
Leu Ser
        


<210> 174
<211> 3042
<212> DNA
<213> Cricetulus griseus

<220> 
<223> Hamster beta klotho

<400> 174
atgtccaaca gggcactgca aagatctgtc gtgctgtcag cgtttgttct gctgcgagct 60
gttaccggat tgtctggaga cgggaaagcg atatgggata aaaaacagta cgtgagtccg 120
gtgaatgcaa gtcagctgtt tctctatgac actttcccta aaaacttttt ctggggtgtt 180
ggaactggag catttcaagt ggaagggaat tggcaggcag acggaagagg accctcgatt 240
tgggatcgtt tcatctacac acacctgaga gatgtcagca tcacagagaa atccgccgac 300
agttacattt ttctggaaaa agatttgttg gctctggatt ttttaggagt ttctttttat 360
cagttctcaa tctcctggcc acggttgttc cccaatggaa cagtagcatc cgtgaatgca 420
aaaggtctcc aatactacaa caaacttctg gactcgctga tacttaggaa tattgagccc 480
gttgttacct tataccattg ggatttgcct ttggcgctac aggaagacta tgggggttgg 540
aaaaatgcaa ctatgataga tctcttcaat gactatgcca catactgctt ccagaccttt 600
ggagaccgtg tcaagtattg gattacaatt cacaaccctt acctggttgc ttggcatggg 660
tttgccacag gtatgcatgc gccaggagag acgggaaatt taacagctgt ctacattgtg 720
ggacacaacc tgatcaaggc tcattcgaaa gtgtggcata actacgacaa aaacttccgc 780
ccccatcaga agggtttgct gtccattacc ttggggtccc actggataga accaaacaaa 840
acagaaaaca tggccgatac aatcagctgc cagcactcta tggcttttgt gcttgggtgg 900
tttgccaacc ccatccatgc agacggcgac taccctgagt tcatgaaaac attgtccacc 960
atgccagtgt tctctgaggc agagaaggag gaggtgaggg gcacagctga cttctttgcc 1020
ttttcctttg ggcccaacaa tttcaggccc tcgaacactg tagtgaaaat gggacaaaat 1080
gtatcactca acttaagaca ggtgctgaac tggattaaat tagaatatga caaccctcga 1140
atcttgattt cggagaatgg ctggttcaca gatagtgaca taaagacaga ggacaccaca 1200
gccatctaca tgatgaagca tttcctcaac caggttcttc aagcaataca gtttgatgaa 1260
atacgagtgt ttggttacac ggcctggtct ctcctggatg gctttgaatg gcagtatgcc 1320
tacacgtctc gccgaggact gttttatgtg gactttaata gtgaacagaa agaaaggaaa 1380
cccaagacct cggcacatta ctacaaacag atcatacaag aaaatggttt ccctttgaaa 1440
gagtccacgc cagacatgca gggtcagttt ccctgtgact tctcctgggg ggtcaccgag 1500
tctgttctta agccggagtt tatggtttcc tccccacagt ttaccgaccc tcacctgtat 1560
gtgtggaatg ccactggcaa cagattgcta cagcgagtag aaggagtaag gctaaaaaca 1620
aaaccatccc actgcacaga ctatgttagc atcaaaaaac gagttgagat gttggccaaa 1680
atgaaagtca cccactacca gtttgctctg gactgggcca ccatccttcc cactggcaat 1740
ctgtctgaag ttaatagaca agtactaagg tactataggt gtgtggtgag cgaaggactg 1800
aagctgggcg tctctcccat ggtgacgttg taccacccca cccactccca tctaggcctc 1860
cctgagccgc ttcttaacag tgggggatgg ctaaacactt acaccgccaa ggccttccag 1920
gactacgcag gactgtgctt ccaggaacta ggggacttgg tgaagctctg gatcaccatc 1980
aatgagccta ataggctgag tgacatgtac aaccgcacga gtaatgacac ctaccgtgca 2040
gcccataacc tgatgattgc ccatgcccag gtctggcgtc tctacgacag gcagtatagg 2100
ccagtccagc atggagctgt gtcgctgtcc ctacattctg actgggtgga acctgccaac 2160
ccctatgtgg actcacactg gaaggcagcg gagcgcttcc tcctgtttga gatcgcctgg 2220
ttcgctgatc cgctcttcaa gactggcgac tatccactgg ccatgaagga gtacatcgcc 2280
tccaagaacc agcaagggct gtcccgctca gtcctgccgc gcttcacccc agaggagagc 2340
aggctggtga agggcaccat cgacttctac gcactgaacc acttcactac taggttcgtg 2400
atacacaaac agctcaacag cagccgctct atggcagaca gggacgtcca gttcctgcag 2460
gacatcaccc gcctgagctc gcccagccgc ctggctgtta tgccctgggg agcacgcaag 2520
ctgcttgggt ggatccagag gaactatggg gacatggaca tctacatcac agccaatggc 2580
atcgatgatc tggctctgga gaatgatggg atccgaaagt actacttgga gaagtacatc 2640
caggaggctc tgaaagcata cctcattgac aaagtcaaaa tcaaaggcta ttatgcattc 2700
aaactgactg aagagaaatc taagcctaga tttggatttt tcacatctga cttcaaagct 2760
aagtcatctg tagagtttta tagcaagttg atcagcagaa gtggcttccc ctctgagact 2820
agcaatcccg catgtggtca gcctccagaa gacacagact gcaccatctg ctcatttttc 2880
actcagaaga aatctctgat cttctttggt tgttgcttca tctccactct ggctgtactg 2940
ctgtcaatca ccatttttca tcatcgaaag agaagatttc ataaatcaaa gaacttagaa 3000
aatataccat tgaaggaagg ccacagtaga gttcttagct aa                    3042

<210> 175
<211> 1044
<212> PRT
<213> Oryctolagus cuniculus

<220> 
<223> rabbit beta klotho

<400> 175
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Val Ser
 1               5                  10                  15      
Phe Cys Thr Asp Glu Arg Asn Arg Arg Cys Arg Glu Thr Met Ser Ser
            20                  25                  30          
Gly Arg Leu Arg Arg Ser Val Met Leu Ser Ala Phe Ile Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Pro Gly Asp Gly Arg Ala Val Trp Ser Gln Asn
    50                  55                  60                  
Pro Asn Leu Ser Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Leu Ser Val Trp Asp His
            100                 105                 110         
Phe Ile Ala Thr His Leu Asn Val Ser Ser Arg Asp Gly Ser Ser Asp
        115                 120                 125             
Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Leu Gly
    130                 135                 140                 
Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp
145                 150                 155                 160 
Gly Thr Val Ala Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Asn Arg
                165                 170                 175     
Leu Leu Asp Ser Leu Leu Leu Arg Asn Ile Glu Pro Val Val Thr Leu
            180                 185                 190         
Tyr His Trp Asp Leu Pro Trp Ala Leu Gln Glu Lys Tyr Gly Gly Trp
        195                 200                 205             
Lys Asn Glu Thr Leu Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys
    210                 215                 220                 
Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn
225                 230                 235                 240 
Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Leu His Ala Pro
                245                 250                 255     
Gly Glu Lys Gly Asn Val Ala Ala Val Tyr Thr Val Gly His Asn Leu
            260                 265                 270         
Leu Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Arg Asn Phe Arg
        275                 280                 285             
Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile
    290                 295                 300                 
Glu Pro Asn Arg Ala Glu Ser Ile Val Asp Ile Leu Lys Cys Gln Gln
305                 310                 315                 320 
Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp
                325                 330                 335     
Gly Asp Tyr Pro Glu Val Met Thr Lys Lys Leu Leu Ser Val Leu Pro
            340                 345                 350         
Ala Phe Ser Glu Ala Glu Lys Asn Glu Val Arg Gly Thr Ala Asp Phe
        355                 360                 365             
Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met
    370                 375                 380                 
Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn
385                 390                 395                 400 
Trp Ile Lys Leu Glu Tyr Gly Asn Pro Arg Ile Leu Ile Ala Glu Asn
                405                 410                 415     
Gly Trp Phe Thr Asp Ser Tyr Val Gln Thr Glu Asp Thr Thr Ala Ile
            420                 425                 430         
Tyr Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Arg Leu
        435                 440                 445             
Asp Gly Val Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly
    450                 455                 460                 
Phe Glu Trp Gln Asp Ala Tyr Asn Thr Arg Arg Gly Leu Phe Tyr Val
465                 470                 475                 480 
Asp Phe Asn Ser Glu Gln Arg Glu Arg Arg Pro Lys Ser Ser Ala His
                485                 490                 495     
Tyr Tyr Lys Gln Val Ile Gly Glu Asn Gly Phe Thr Leu Arg Glu Ala
            500                 505                 510         
Thr Pro Asp Leu Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val
        515                 520                 525             
Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe
    530                 535                 540                 
Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Met Leu
545                 550                 555                 560 
His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr
                565                 570                 575     
Asp Phe Ile Thr Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys
            580                 585                 590         
Val Thr His Phe Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr
        595                 600                 605             
Gly Asn Leu Ser Glu Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys
    610                 615                 620                 
Val Val Thr Glu Gly Leu Lys Leu Asn Ile Ser Pro Met Val Thr Leu
625                 630                 635                 640 
Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Ala Pro Leu Leu His
                645                 650                 655     
Ser Gly Gly Trp Leu Asp Pro Ser Thr Ala Lys Ala Phe Arg Asp Tyr
            660                 665                 670         
Ala Gly Leu Cys Phe Arg Glu Leu Gly Asp Leu Val Lys Leu Trp Ile
        675                 680                 685             
Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Val Tyr Asn Arg Thr Ser
    690                 695                 700                 
Asn Asp Thr Tyr Gln Ala Ala His Asn Leu Leu Ile Ala His Ala Leu
705                 710                 715                 720 
Val Trp His Leu Tyr Asp Arg Gln Tyr Arg Pro Ser Gln Arg Gly Ala
                725                 730                 735     
Leu Ser Leu Ser Leu His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr
            740                 745                 750         
Val Ala Ser His Trp Gln Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile
        755                 760                 765             
Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Val Ala
    770                 775                 780                 
Met Arg Glu Tyr Ile Ala Ser Lys Thr Arg Arg Gly Leu Ser Ser Ser
785                 790                 795                 800 
Val Leu Pro Arg Phe Ser Asp Ala Glu Arg Arg Leu Val Lys Gly Ala
                805                 810                 815     
Ala Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His
            820                 825                 830         
Glu Gln Gln Asn Gly Ser Arg Tyr Asp Ser Asp Arg Asp Val Gln Phe
        835                 840                 845             
Leu Gln Asp Ile Thr Arg Leu Ala Ser Pro Ser Arg Leu Ala Val Met
    850                 855                 860                 
Pro Trp Gly Glu Gly Lys Leu Leu Arg Trp Met Arg Asn Asn Tyr Gly
865                 870                 875                 880 
Asp Leu Asp Val Tyr Ile Thr Ala Asn Gly Ile Asp Asp Gln Ala Leu
                885                 890                 895     
Gln Asn Asp Gln Leu Arg Gln Tyr Tyr Leu Glu Lys Tyr Val Gln Glu
            900                 905                 910         
Ala Leu Lys Ala Tyr Leu Ile Asp Lys Ile Lys Ile Lys Gly Tyr Tyr
        915                 920                 925             
Ala Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe
    930                 935                 940                 
Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Leu
945                 950                 955                 960 
Ile Thr Ser Asn Gly Phe Pro Ser Glu Asn Gly Gly Pro Arg Cys Asn
                965                 970                 975     
Gln Thr Gln Gly Asn Pro Glu Cys Thr Val Cys Leu Leu Leu Leu Gln
            980                 985                 990         
Lys Lys Pro Leu Ile Phe Phe Ser Cys Cys Phe Phe Cys Thr Leu Val
        995                 1000                1005            
Leu Leu Ser Ser Ile Thr Ile Phe His Arg Arg Lys Arg Arg Lys Phe
    1010                1015                1020                
Trp Lys Ala Lys Asp Leu Gln His Ile Pro Leu Lys Lys Gly His Lys
1025                1030                1035                1040
Arg Val Leu Ser
                


<210> 176
<211> 5737
<212> DNA
<213> Oryctolagus cuniculus

<220> 
<223> rabbit beta klotho

<400> 176
tgaagccgtg ataagacggt cccgcagttc gtggcaaatg aagccaggct gtgcggcagg 60
atctccaggg aatgaatggg tttccttctg caccgatgaa agaaacagac gctgtaggga 120
aacgatgtcc agcggacgcc tgcggagatc tgtcatgctg tcagccttca tcctgctgcg 180
agccgtgact gggttccccg gagacggaag agctgtatgg tcgcaaaatc ctaatttgag 240
tccggtaaac gaaagtcagc tgtttctcta tgacactttc ccaaaaaact ttttctgggg 300
tgtggggact ggagccttcc aagtggaagg gagttggaag aaggatggga aaggactctc 360
tgtatgggat catttcatcg ctacacacct gaacgtcagc agccgcgatg gctccagtga 420
cagctacatt tttttggaga aagacttatc ggcgctggat tttttaggag tctcttttta 480
tcagttttca atttcctggc caagactgtt cccggatggc acagtagcag tcgccaatgc 540
aaaaggtctc cagtactata atcggctcct ggactctctg ctacttagaa acattgaacc 600
tgtagtcact ttataccatt gggatctgcc ttgggcgcta caagaaaaat acggggggtg 660
gaaaaacgag acgttgattg atttattcaa tgactatgcc acctactgtt tccagacgtt 720
tggggaccgt gtcaaatact ggatcaccat tcacaatccc tatctggtgg cttggcatgg 780
ctacgggaca ggtctgcatg ctccgggaga gaaggggaat gtggcagctg tctacactgt 840
gggacacaac ctgcttaagg ctcattcaaa agtctggcac aactacaaca ggaatttccg 900
cccgcatcag aaaggctggc tgtcgatcac gctgggatcc cactggattg agccaaacag 960
agcggaaagc atcgtggaca tactcaagtg ccagcagtcc atggtctcgg tgctgggctg 1020
gtttgccaac ccgatccacg gggacgggga ctacccagag gtgatgacaa agaagctgct 1080
ctccgtcctg cccgctttct cagaagcaga gaagaacgag gtacgaggca ccgcagactt 1140
ctttgccttt tcgtttggac ccaacaactt caagccctta aacaccatgg ctaaaatggg 1200
gcagaatgtg tcactcaatc taagacaggt gctgaactgg attaaactgg aatatggcaa 1260
ccctcgaatc ctgatcgctg agaacggctg gttcacagac agttacgtgc aaacagaaga 1320
caccacagcc atctacatga tgaagaattt cctcaaccag gttcttcaag caataaggtt 1380
ggatggagtc cgagtgtttg gctacactgc ctggtctctc ctggatggct tcgaatggca 1440
ggacgcttac aacacccgcc gtggactgtt ttatgtggac ttcaacagcg aacagagaga 1500
aagaaggccc aagtcctcgg cgcattacta taaacaggtc ataggagaaa acggcttcac 1560
gctcagagag gccaccccgg atctgcaggg gcagtttccc tgtgacttct cctggggcgt 1620
caccgagtct gttcttaagc ccgagtcggt ggcttcctcg ccacagttca gcgaccctca 1680
cctctacgtg tggaacgcca ctggcaaccg aatgcttcac cgggtggaag gggtgaggct 1740
gaaaacacgg cccgctcagt gcacagattt catcaccatc aagaaacaac tcgagatgtt 1800
ggcaagaatg aaagtcaccc acttccggtt tgctctggac tgggcctcgg tccttcccac 1860
gggcaacctg tccgaggtga accgacaagc cctgaggtac tacaggtgtg tggtcaccga 1920
ggggctgaag ctcaacatct cgcccatggt caccttgtac tacccgaccc atgcccacct 1980
gggcctgccc gcgccgctgc tgcacagcgg ggggtggctg gacccatcca cggccaaggc 2040
cttccgcgac tacgcagggc tgtgcttccg ggagctgggg gacctggtga agctctggat 2100
caccatcaac gagcccaacc ggctgagcga cgtctacaac cgcaccagca acgacaccta 2160
ccaggccgcc cacaacctgc tgatcgcgca cgcgctcgtg tggcacctgt acgaccgcca 2220
gtaccggccg tcgcagcgcg gggcgctgtc gctgtccctg cactcggact gggccgagcc 2280
cgccaacccc tacgtggcct cgcactggca ggcggccgag cgcttcctgc agttcgagat 2340
tgcgtggttc gccgagcccc tgttcaagac cggggactac ccggtggcca tgagggagta 2400
catcgcctcc aagacccggc gcgggctctc cagctccgtg ctgccccgct tcagcgacgc 2460
cgagcggcgg ctggtcaagg gcgccgccga cttctacgcc ctcaaccact tcaccaccag 2520
gttcgtgatg cacgagcagc agaacggcag ccgctacgac tcggacaggg acgtgcagtt 2580
cctgcaggac atcacccgcc tggcctcacc cagccgcctg gccgtgatgc cctggggcga 2640
gggcaagctg ctgcggtgga tgcggaacaa ctacggagac ctggacgtct acatcacggc 2700
caatggcatc gacgaccagg ccctgcagaa cgaccagctt cgccagtact acctggagaa 2760
gtacgtccag gaggctctga aagcatatct gatagataaa ataaaaatca aaggctatta 2820
tgcattcaaa ctgactgaag aaaaatctaa acccaggttt ggattcttca cctctgattt 2880
caaagccaag tcttcaatac agttttacaa caaactaatt accagcaacg gcttcccgtc 2940
tgagaacggc ggtcctagat gcaatcagac tcaaggaaat cccgagtgca ccgtctgctt 3000
actcctcctg cagaagaagc cgctgatatt ctttagctgc tgcttcttct gcaccctggt 3060
tctactctca tcaattacca tctttcacag acggaagaga agaaaatttt ggaaagcaaa 3120
ggacttacaa cacataccat taaagaaagg ccacaagaga gtccttagct aaagtgaact 3180
tatttctctc tgaagagttt agaaattcac tccagttcca tatgctggta acacaaaaga 3240
catacccgta ttgtacacag agtatttgag atactgtgct aaccaaggcg atgacaatca 3300
aaacctctgc catgtggttg aatgcatttt cccttaagcg gtgacaatca gcgaactcag 3360
ttcttggttc taaaggaggc ttcgcactgc cactaggcta tgagtattac ctgacgcatt 3420
gctttgtcaa gtttgatgag ctgtttcgca tcattctcta gctttcttta gataccaata 3480
gctactatgg taaaagttgt ttttaaaagt caaactctgt aaggcttcac agcagattta 3540
aaactattct ttacactgga tctgtgattt tgtcactcgt agcaaggtgc tttccccttt 3600
tggtcctagt ggctctcaaa tagaaagcaa acacatctta gggtaatcta cttatctata 3660
gccaatcaca gcactgaccc acaactacac aaatccgtta gctcttctcc ataaaacacc 3720
taattttgtg atcttttaag taatctgaaa tgtaaaagta tgacttccgt aacccatctc 3780
atggaaagat cgactaagga gagccatacc cagctgtgag gacaatttag tcactaatct 3840
caccgtactg caacttcctc ctttagagca ggcattcctt accatttttg taagatgaca 3900
tgatttagca tctagaaccc ctatctgcag tttctttcta tggcttacct acatttcaag 3960
aatattgaac ggaaaatttc agaaagattt ccaagtttta aattgtgtac tagcattagt 4020
gcatgatgaa atctcatttt ctttgctcca tcctgcacag gatgtgaaac atccctctgt 4080
ccagcaagtc caagctacct atattactca cttgatagtc accatggtta tccagctgtt 4140
attacttgct catacccagg taaccctttt ttattttaat atagctccaa agtataagac 4200
tagtgatgaa aaggaggtaa gtcatcaaat atggaaggac agattaactc tggcactaag 4260
tgggaatgct gcaggtttta caggaaaaca aaattcagtc agtggtttaa agcatcctct 4320
gaggtacctg gggcacaatc tccacagata aggggaaaga gcactgacaa agactaaaca 4380
tcctaaaaag acgcaatgtt ctacttactg gccatcagaa taatggccaa aggaccctat 4440
acttgcttgc tctctagcca agtttcgctg cacataggtg tagaatgcag cgactgaccc 4500
tggatgcgat tcagaatgct gatctgagtg aactagtttt ttatacagca ctttttaaag 4560
cctagaattc ttccatctga acttgggagt tttgactttt ttgaaattaa ttgtgcttaa 4620
gatttattca gtgattctaa acactggagg tagaaaactg tatacccatt atgcctatta 4680
atttttcttg attagccaac atttaaataa ccacaaagtg gccagtcgtt gtctttccct 4740
ttcaggaatt taagtcaaag gatgctgctg cctgcgatgc tggcacttca taggggtgac 4800
agtttgtgtc cctgcggttc cacttcctat ccagctccct gctaatggct tgggagagcc 4860
ctgcacccac atgggagacc caaaagcaga tcctgctgct ttcagcctgc tgcggccact 4920
tggagtatga accagtggat ggaagatcaa tgtctctccc aacaattctt tgaataaatt 4980
ttttcaaaag tcaaaataaa attctccagc tcaaaaagct ttagtagaaa acgatcctac 5040
attaaggcgg ttgtgattgt atcccaagtg catctacgtt acaaaccaaa ttgagtatgc 5100
aattcagtat gctactagac tataaggaga aaacagccaa ttcaaacaaa ataccaaagt 5160
cacgtgcagt taatttgctt tctggttggc caaatgtttt ttttctcttc ttgccaccac 5220
tgttttacat gtactttaga agaaattttg actttttgct tcctttgaga aatcactatt 5280
atcaaaggca attcataatt acaagtggtc cattgtctta agagctcaag attatagccc 5340
ttcaaacttg ccaaactcct caaatagtga agctcctaac gaagggttta caacatcctg 5400
ttccttaggg gttatatttt taagtgactg taatttacct aacaaattta atctggctat 5460
ctattggtaa tacatgtaat attcaggttt atcataaacc cacttaaaaa ctaaaggtta 5520
agtggaagtt gctgcttttc aaagtaacag gcttctcagg ggaaaatatc accttagcgt 5580
ccacctggta ctacatctcg tgtattcact gtaacccatc tttccgaaca tgtctgatat 5640
atatggaaac aacactagtg cttagcctct ggaaatgagg ccaggatttt gtgattaaat 5700
gtctaattta ttccaaataa actgatttac gccaata                          5737



<210> 177
<211> 1045
<212> PRT
<213> Canis lupus familiaris

<220> 
<223> dog beta klotho

<400> 177
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Leu Ser Thr Asp Glu Ser Asn Thr His Tyr Arg Lys Thr Met Cys Asn
            20                  25                  30          
His Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Phe Ile Leu Leu Gly
        35                  40                  45              
Ala Val Pro Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn
    50                  55                  60                  
Pro His Phe Ser Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Asn Trp Lys Thr Asp Gly Lys Gly Pro Ser Ile Trp Asp His
            100                 105                 110         
Phe Ile His Thr His Leu Lys Asn Val Asn Ser Met Asn Ser Ser Ser
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asp Gly Ile Ala Ala Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Asn
                165                 170                 175     
Ser Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Glu Thr Ile Thr Asp Ile Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr Asn Phe
        275                 280                 285             
Arg Pro Tyr Gln Lys Gly Leu Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Ser Glu Asn Met Met Asp Ile Leu Lys Cys Gln
305                 310                 315                 320 
Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asn Gly Asp Tyr Pro Glu Val Met Lys Lys Lys Leu Leu Ser Thr Leu
            340                 345                 350         
Pro Leu Phe Ser Glu Ala Glu Lys Asn Glu Val Arg Gly Thr Ala Asp
        355                 360                 365             
Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Gln Asn Thr
    370                 375                 380                 
Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Val Leu
385                 390                 395                 400 
Asn Trp Ile Lys Leu Glu Tyr Gly Asn Pro Arg Ile Leu Ile Ala Glu
                405                 410                 415     
Asn Gly Trp Phe Thr Asp Ser His Val Lys Thr Glu Asp Thr Thr Ala
            420                 425                 430         
Ile Tyr Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Arg
        435                 440                 445             
Phe Asp Glu Ile Gln Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp
    450                 455                 460                 
Gly Phe Glu Trp Gln Asp Ala Tyr Ser Thr Arg Arg Gly Leu Phe Tyr
465                 470                 475                 480 
Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala
                485                 490                 495     
Tyr Tyr Tyr Lys Gln Ile Ile Gln Glu Asn Gly Phe Thr Phe Lys Glu
            500                 505                 510         
Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly
        515                 520                 525             
Val Thr Glu Ser Val Leu Lys Pro Lys Val Val Ala Ser Ser Pro Gln
    530                 535                 540                 
Phe Ser Asp Pro His Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu
545                 550                 555                 560 
Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys
                565                 570                 575     
Thr Asp Phe Val Ser Ile Lys Arg Gln Leu Glu Met Leu Ala Arg Met
            580                 585                 590         
Asn Val Thr His Tyr Arg Phe Ala Leu Asp Trp Pro Ser Ile Leu Pro
        595                 600                 605             
Thr Gly Asn Leu Ser Thr Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg
    610                 615                 620                 
Cys Val Val Ser Glu Ser Leu Lys Leu Ser Ile Ser Pro Met Val Thr
625                 630                 635                 640 
Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Ser Pro Leu Leu
                645                 650                 655     
His Ser Gly Gly Trp Leu Asn Ala Ser Thr Ala Arg Ala Phe Gln Asp
            660                 665                 670         
Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp
        675                 680                 685             
Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Val Tyr Ser His Thr
    690                 695                 700                 
Ser Ser Asp Thr Tyr Arg Ala Ala His Asn Leu Leu Ile Ala His Ala
705                 710                 715                 720 
Leu Val Trp His Leu Tyr Asp Arg Arg Tyr Arg Pro Ala Gln Arg Gly
                725                 730                 735     
Ala Val Ser Leu Ser Leu His Ser Asp Trp Ala Glu Pro Ala Asn Pro
            740                 745                 750         
Tyr Ala Asp Ser His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu
        755                 760                 765             
Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Pro
    770                 775                 780                 
Ala Met Arg Glu Tyr Ile Ala Ser Lys Asn Arg Gln Gly Leu Ser Arg
785                 790                 795                 800 
Ser Thr Leu Pro Arg Phe Thr Asp Glu Glu Arg Arg Leu Val Lys Gly
                805                 810                 815     
Ala Ala Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Met
            820                 825                 830         
His Ala Arg Gln Asn Gly Ser Arg Tyr Asp Ala Asp Arg Asp Val Gln
        835                 840                 845             
Phe Leu Gln Asp Ile Thr Cys Leu Ser Ser Pro Ser Arg Leu Ala Val
    850                 855                 860                 
Leu Pro Trp Gly Glu Arg Lys Val Leu Arg Trp Ile Gln Lys Asn Tyr
865                 870                 875                 880 
Gly Asp Val Asp Val Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ser
                885                 890                 895     
Leu Glu Asn Asp Glu Leu Arg Lys Tyr Tyr Leu Glu Lys Tyr Ile Gln
            900                 905                 910         
Glu Ala Leu Lys Ala His Leu Ile Asp Lys Val Lys Val Lys Gly Tyr
        915                 920                 925             
Tyr Ala Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe
    930                 935                 940                 
Phe Thr Ser Glu Phe Lys Ala Lys Ser Ser Val Gln Leu Tyr Asn Lys
945                 950                 955                 960 
Leu Ile Ser Asn Ser Gly Phe Pro Ser Glu Asn Arg Ser Pro Arg Cys
                965                 970                 975     
Ser Glu Thr Gln Arg Asn Thr Glu Cys Met Val Cys Leu Phe Leu Val
            980                 985                 990         
Gln Lys Lys Pro Leu Ile Phe Phe Ser Cys Cys Phe Phe Ser Thr Leu
        995                 1000                1005            
Val Leu Leu Ser Ser Ile Thr Ile Leu His Lys Arg Lys Arg Arg Lys
    1010                1015                1020                
Ile Trp Lys Ala Lys Asn Leu Gln His Ile Pro Leu Lys Lys Ser Lys
1025                1030                1035                1040
Asn Ser Leu Gln Ser
                1045


<210> 178
<211> 4350
<212> DNA
<213> Canis lupus familiaris

<220> 
<223> dog beta klotho

<400> 178
acaatcacaa gcttttactg aagcgttgat aagacaggcg agcagttagt ggcaaatgaa 60
gccaggctgt gcggctggat ctccagggaa tgaatggatt ttcctcagca ccgatgaaag 120
caacacacac tataggaaaa caatgtgcaa ccacgggcta cagagatctg tcatcctgtc 180
agcatttatt ctcctaggag ctgttcctgg attctctgga gacggaagag ctatatggtc 240
taaaaatcct cattttagtc cggtaaatga aagtcagctg tttctctatg acacttttcc 300
taaaaacttt ttttggggcg ttgggactgg agcatttcaa gtggaaggga attggaagac 360
agatggaaaa ggaccctcta tatgggatca tttcatccac acacacctta aaaatgtcaa 420
cagcatgaat agttccagtg acagttacat ttttctggaa aaagacctat cagccctgga 480
ttttatcgga gtttcttttt atcaattttc aatttcctgg ccaaggcttt tccccgatgg 540
aatagcagca gttgccaacg caaaaggtct ccagtactac aattctcttc tcgatgctct 600
agtacttagg aacattgaac ctatagttac tttataccat tgggatttgc ctttggcact 660
acaagaaaaa tatggggggt ggaaaaatga aaccataacg gatatcttca atgactatgc 720
cacctactgt ttccagacgt tcggggatcg tgtcaaatac tggattacaa ttcacaatcc 780
atatctagtt gcttggcatg ggtatgggac aggtatgcac gcgcctggag agaagggaaa 840
cttagcagct gtctacactg tgggacacaa cctaatcaag gctcattcga aagtttggca 900
taactacaac acaaatttcc gcccatatca gaagggtttg ttatcaatca cgttgggatc 960
ccattggatt gaaccaaaca gatcagaaaa catgatggat atactcaaat gtcaacaatc 1020
catggtttca gtgctcgggt ggtttgccaa ccccatccat gggaatggag actatccaga 1080
agtgatgaaa aagaagttgc tctccactct accccttttc tctgaagcag agaagaatga 1140
agtgaggggc acagctgact tctttgcctt ttcctttgga cccaacaatt tcaagcccca 1200
gaacaccatg gctaaaatgg gacaaaatgt gtcactcaat ttaagagaag tgctgaattg 1260
gattaaactg gaatatggca acccccgaat cttgattgct gagaatggct ggttcacaga 1320
cagtcatgtg aaaacagaag ataccacagc catttacatg atgaagaatt tcctcaacca 1380
ggttcttcaa gcaataaggt ttgacgaaat acaagtgttt ggctacactg cttggtctct 1440
cctggatggc tttgaatggc aggatgctta ctccactcgc cgaggattat tttatgtgga 1500
ttttaatagt aaacaaaaag aaagaaagcc caagtcttcg gcatattact ataaacagat 1560
catacaagaa aatggtttta ctttcaaaga gtccacccca gatgtgcagg gtcagtttcc 1620
ctgtgacttc tcatggggtg tcaccgaatc tgtccttaag cccaaagtcg tggcttcctc 1680
cccacagttc agcgaccctc acctgtacgt gtggaatgtg acaggcaaca gactgttgca 1740
ccgagtggaa ggggtgaggc tgaagacacg gccggctcaa tgcacagatt ttgtcagcat 1800
caaaagacaa cttgagatgt tggcgaggat gaacgtcact cactacaggt ttgctctgga 1860
ctggccctcc atccttccca ccggcaacct gtccacggtt aaccgacaag ccctgaggta 1920
ctacaggtgt gtggtcagcg agtcgctgaa gctcagcatc tccccgatgg tcacgctgta 1980
ctacccgacc cacgcccacc tgggcctccc ctcgccgctg ctgcacagcg ggggctggct 2040
gaacgcgtcc accgcccgcg ccttccagga ctatgccggg ctgtgcttcc aggagctggg 2100
ggacctggtg aagctctgga tcaccatcaa tgagcccaac cggctgagtg acgtctacag 2160
ccacaccagc agcgacacct accgggcagc gcacaacctg ctgatcgccc acgccctggt 2220
gtggcacctg tacgaccggc ggtaccggcc ggcgcagcgc ggggccgtgt cgctgtccct 2280
gcactcggac tgggcggagc ccgccaaccc ctacgccgac tcgcactgga aggcggccga 2340
gcgcttcctg cagttcgaaa tcgcctggtt cgccgagccg ctcttcaaga ccggggacta 2400
cccgccggcc atgagggagt acatcgcctc caagaacagg caggggctct cgcgctccac 2460
cctgccccgc ttcaccgacg aggagaggag gctggtcaag ggcgccgccg acttctacgc 2520
gctgaaccac ttcaccacca ggttcgtgat gcacgcgcgc cagaacggca gccgctacga 2580
cgcggaccgc gacgtccagt tcctgcagga catcacctgc ctgagctccc ccagccgcct 2640
ggccgtcctg ccctgggggg agcgcaaggt gctcaggtgg atccagaaga actacggaga 2700
cgtggacgtg tacatcacgg ccagtggcat cgatgaccag tctctggaaa atgatgagct 2760
cagaaaatac tacttggaga aatacatcca ggaggctctg aaagcacacc taattgataa 2820
agtcaaagtc aaaggctatt atgcattcaa actgactgaa gaaaaatcta aacccagatt 2880
tggattcttc acgtctgaat tcaaagctaa atcctcagtt cagctttaca acaaactgat 2940
cagcaacagt ggcttccctt ctgagaacag gagtcctaga tgcagtgaga ctcaaagaaa 3000
cacagagtgc atggtctgct tatttcttgt gcaaaagaaa ccactgatat tctttagttg 3060
ttgcttcttc tctaccctgg ttctactttc atcgattacc attcttcata agcgaaagag 3120
aagaaaaatt tggaaagcaa agaacttaca acatatacca ttaaagtgag gccacagaaa 3180
gttcttagtg aaactgatcc tatttctgtc tgcatgatag aaagtctaaa aattcactcc 3240
agtcccaaat actggtaaca tagaagacaa tttgaaacac tagtagtaac caaggtgatg 3300
acaatcaagg tctctgctgt gtggtccaaa tgaattttcc attaggtgtt gacatcactg 3360
aatacagttt ttagatctga agactaagat ctagagagta agctaggatt atctgataca 3420
atgcttcatt aagtttaata agctgttatc catcattctt ctctggcttc cttctagaaa 3480
taccaatagc taattatagc aacttagaaa aaagtgcaac ttttgctaga ctccatagca 3540
gaaatctaaa actcttaaca ctggatattc agtgattatt ctatcacttc taacaaggtg 3600
cttttcccct ttagaagata tacaataggg taaatagtgc tcctttatca tccattccag 3660
cacttttttt ttccagcata gactcttaaa cacattgatc ctagtttttc tcaatagaaa 3720
taaaaaatca tttagaaaac atggaatttt gtgaggtctc tccttgcatt agatctgagt 3780
tttttttaaa aaaaagactt aacttccata acccatctca tgggaagatc acaggactaa 3840
gattaaggag agttagaccc atcaactgcc tgaggagaca gcactcaacc tcacagtaca 3900
gcaaattcct tgggacaaac tgacagcaat cttccgcact tggattgttg aggcagcaca 3960
caagatctta acatacttag gaaagttaaa tattctaaaa agatgtaaag ttttattttt 4020
attatcaagt cttcaaagga ccatattatt ccataagact tgctctctcc tgagttccac 4080
tcttctgaca ctatgtgtat atggggacac tcaaactgca ccttgacatt gcaactttgg 4140
atacaattca gaatgtaaat gtttgaagga cttaaaactt tctccactgc accttttgaa 4200
gctgggatta agtaaatacg aactgggagt ttgacttttt tgaactctgt gcttgattta 4260
ttcactgtat tctaaatttt aaggaaaacc tgaatgtaaa cccattcata ccctttcttt 4320
gggttagtaa acatttaacc acccatttca                                  4350

<210> 179
<211> 1045
<212> PRT
<213> Artificial Sequence

<220> 
<223> human/mouse beta klotho chimeric protein 
(human KLB (M1-F508)-mouse KLB (P507-S1043)

<400> 179
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn
            20                  25                  30          
Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn
    50                  55                  60                  
Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His
            100                 105                 110         
Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser
                165                 170                 175     
Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln
305                 310                 315                 320 
Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu
            340                 345                 350         
Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp
        355                 360                 365             
Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr
    370                 375                 380                 
Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu
385                 390                 395                 400 
Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu
                405                 410                 415     
Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala
            420                 425                 430         
Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg
        435                 440                 445             
Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp
    450                 455                 460                 
Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr
465                 470                 475                 480 
Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala
                485                 490                 495     
His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Pro Leu Lys Glu
            500                 505                 510         
Ser Thr Pro Asp Met Lys Gly Arg Phe Pro Cys Asp Phe Ser Trp Gly
        515                 520                 525             
Val Thr Glu Ser Val Leu Lys Pro Glu Phe Thr Val Ser Ser Pro Gln
    530                 535                 540                 
Phe Thr Asp Pro His Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu
545                 550                 555                 560 
Leu Tyr Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ser Gln Cys
                565                 570                 575     
Thr Asp Tyr Val Ser Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met
            580                 585                 590         
Lys Val Thr His Tyr Gln Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro
        595                 600                 605             
Thr Gly Asn Leu Ser Lys Val Asn Arg Gln Val Leu Arg Tyr Tyr Arg
    610                 615                 620                 
Cys Val Val Ser Glu Gly Leu Lys Leu Gly Val Phe Pro Met Val Thr
625                 630                 635                 640 
Leu Tyr His Pro Thr His Ser His Leu Gly Leu Pro Leu Pro Leu Leu
                645                 650                 655     
Ser Ser Gly Gly Trp Leu Asn Met Asn Thr Ala Lys Ala Phe Gln Asp
            660                 665                 670         
Tyr Ala Glu Leu Cys Phe Arg Glu Leu Gly Asp Leu Val Lys Leu Trp
        675                 680                 685             
Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr
    690                 695                 700                 
Ser Asn Asp Thr Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala
705                 710                 715                 720 
Gln Val Trp His Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly
                725                 730                 735     
Ala Val Ser Leu Ser Leu His Cys Asp Trp Ala Glu Pro Ala Asn Pro
            740                 745                 750         
Phe Val Asp Ser His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu
        755                 760                 765             
Ile Ala Trp Phe Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ser
    770                 775                 780                 
Val Met Lys Glu Tyr Ile Ala Ser Lys Asn Gln Arg Gly Leu Ser Ser
785                 790                 795                 800 
Ser Val Leu Pro Arg Phe Thr Ala Lys Glu Ser Arg Leu Val Lys Gly
                805                 810                 815     
Thr Val Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile
            820                 825                 830         
His Lys Gln Leu Asn Thr Asn Arg Ser Val Ala Asp Arg Asp Val Gln
        835                 840                 845             
Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val
    850                 855                 860                 
Thr Pro Trp Gly Val Arg Lys Leu Leu Ala Trp Ile Arg Arg Asn Tyr
865                 870                 875                 880 
Arg Asp Arg Asp Ile Tyr Ile Thr Ala Asn Gly Ile Asp Asp Leu Ala
                885                 890                 895     
Leu Glu Asp Asp Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln
            900                 905                 910         
Glu Ala Leu Lys Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr
        915                 920                 925             
Tyr Ala Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe
    930                 935                 940                 
Phe Thr Ser Asp Phe Arg Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys
945                 950                 955                 960 
Leu Ile Ser Ser Ser Gly Leu Pro Ala Glu Asn Arg Ser Pro Ala Cys
                965                 970                 975     
Gly Gln Pro Ala Glu Asp Thr Asp Cys Thr Ile Cys Ser Phe Leu Val
            980                 985                 990         
Glu Lys Lys Pro Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu
        995                 1000                1005            
Ala Val Leu Leu Ser Ile Thr Val Phe His His Gln Lys Arg Arg Lys
    1010                1015                1020                
Phe Gln Lys Ala Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His
1025                1030                1035                1040
Ser Arg Val Phe Ser
                1045


<210> 180
<211> 3138
<212> DNA
<213> Artificial Sequence

<220> 
<223> human/mouse beta klotho chimeric protein

<400> 180
atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt cagcactgat 60
gaaataacca cacgctatag gaatacaatg tccaacgggg gattgcaaag atctgtcatc 120
ctgtcagcac ttattctgct acgagctgtt actggattct ctggagatgg aagagctata 180
tggtctaaaa atcctaattt tactccggta aatgaaagtc agctgtttct ctatgacact 240
ttccctaaaa actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300
aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca ccttaaaaat 360
gtcagcagca cgaatggttc cagtgacagt tatatttttc tggaaaaaga cttatcagcc 420
ctggatttta taggagtttc tttttatcaa ttttcaattt cctggccaag gcttttcccc 480
gatggaatag taacagttgc caacgcaaaa ggtctgcagt actacagtac tcttctggac 540
gctctagtgc ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600
gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat cttcaatgac 660
tatgccacat actgtttcca gatgtttggg gaccgtgtca aatattggat tacaattcac 720
aacccatatc tagtggcttg gcatgggtat gggacaggta tgcatgcccc tggagagaag 780
ggaaatttag cagctgtcta cactgtggga cacaacttga tcaaggctca ctcgaaagtt 840
tggcataact acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900
ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt caaatgtcaa 960
caatccatgg tttctgtgct tggatggttt gccaacccta tccatgggga tggcgactat 1020
ccagagggga tgagaaagaa gttgttctcc gttctaccca ttttctctga agcagagaag 1080
catgagatga gaggcacagc tgatttcttt gccttttctt ttggacccaa caacttcaag 1140
cccctaaaca ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200
aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa tggctggttc 1260
acagacagtc gtgtgaaaac agaagacacc acggccatct acatgatgaa gaatttcctc 1320
agccaggtgc ttcaagcaat aaggttagat gaaatacgag tgtttggtta tactgcctgg 1380
tctctcctgg atggctttga atggcaggat gcttacacca tccgccgagg attattttat 1440
gtggatttta acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500
cagatcatac gagaaaatgg ttttcctttg aaagagtcca cgccagacat gaagggtcgg 1560
ttcccctgtg atttctcttg gggagtcact gagtctgttc ttaagcccga gtttacggtc 1620
tcctccccgc agtttaccga tcctcacctg tatgtgtgga atgtcactgg caacagattg 1680
ctctaccgag tggaaggggt aaggctgaaa acaagaccat cccagtgcac agattatgtg 1740
agcatcaaaa aacgagttga aatgttggca aaaatgaaag tcacccacta ccagtttgct 1800
ctggactgga cctctatcct tcccactggc aatctgtcca aagttaacag acaagtgtta 1860
aggtactata ggtgtgtggt gagcgaagga ctgaagctgg gcgtcttccc catggtgacg 1920
ttgtaccacc caacccactc ccatctcggc ctccccctgc cacttctgag cagtgggggg 1980
tggctaaaca tgaacacagc caaggccttc caggactacg ctgagctgtg cttccgggag 2040
ttgggggact tggtgaagct ctggatcacc atcaatgagc ctaacaggct gagtgacatg 2100
tacaaccgca cgagtaatga cacctaccgt gcagcccaca acctgatgat cgcccatgcc 2160
caggtctggc acctctatga taggcagtat aggccggtcc agcatggggc tgtgtcgctg 2220
tccttacatt gcgactgggc agaacctgcc aacccctttg tggattcaca ctggaaggca 2280
gccgagcgct tcctccagtt tgagatcgcc tggtttgcag atccgctctt caagactggc 2340
gactatccat cggttatgaa ggaatacatc gcctccaaga accagcgagg gctgtctagc 2400
tcagtcctgc cgcgcttcac cgcgaaggag agcaggctgg tgaagggtac cgtcgacttc 2460
tacgcactga accacttcac tacgaggttc gtgatacaca agcagctgaa caccaaccgc 2520
tcagttgcag acagggacgt ccagttcctg caggacatca cccgcctaag ctcgcccagc 2580
cgcctggctg taacaccctg gggagtgcgc aagctccttg cgtggatccg gaggaactac 2640
agagacaggg atatctacat cacagccaat ggcatcgatg acctggctct agaggatgat 2700
cagatccgaa agtactactt ggagaagtat gtccaggagg ctctgaaagc atatctcatt 2760
gacaaggtca aaatcaaagg ctactatgca ttcaaactga ctgaagagaa atctaagcct 2820
agatttggat ttttcacctc tgacttcaga gctaagtcct ctgtccagtt ttacagcaag 2880
ctgatcagca gcagtggcct ccccgctgag aacagaagtc ctgcgtgtgg tcagcctgcg 2940
gaagacacag actgcaccat ttgctcattt ctcgtggaga agaaaccact catcttcttc 3000
ggttgctgct tcatctccac tctggctgta ctgctatcca tcaccgtttt tcatcatcaa 3060
aagagaagaa aattccagaa agcaaggaac ttacaaaata taccattgaa gaaaggccac 3120
agcagagttt tcagctga                                               3138

<210> 181
<211> 1042
<212> PRT
<213> Artificial Sequence

<220> 
<223> mouse/human beta klotho chimeric protein 
(mouse KLB (M1-F506) - human KLB(S509-S1044))

<400> 181
Met Lys Thr Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe
 1               5                  10                  15      
Phe Ser Ser Asp Glu Arg Asn Thr Arg Ser Arg Lys Thr Met Ser Asn
            20                  25                  30          
Arg Ala Leu Gln Arg Ser Ala Val Leu Ser Ala Phe Val Leu Leu Arg
        35                  40                  45              
Ala Val Thr Gly Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys
    50                  55                  60                  
Gln Tyr Val Ser Pro Val Asn Pro Ser Gln Leu Phe Leu Tyr Asp Thr
65                  70                  75                  80  
Phe Pro Lys Asn Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val
                85                  90                  95      
Glu Gly Ser Trp Lys Thr Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg
            100                 105                 110         
Tyr Val Tyr Ser His Leu Arg Gly Val Asn Gly Thr Asp Arg Ser Thr
        115                 120                 125             
Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu
    130                 135                 140                 
Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro
145                 150                 155                 160 
Asn Gly Thr Val Ala Ala Val Asn Ala Gln Gly Leu Arg Tyr Tyr Arg
                165                 170                 175     
Ala Leu Leu Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr
            180                 185                 190         
Leu Tyr His Trp Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly
        195                 200                 205             
Trp Lys Asn Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr
    210                 215                 220                 
Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
225                 230                 235                 240 
Asn Pro Tyr Leu Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala
                245                 250                 255     
Pro Gly Glu Lys Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn
            260                 265                 270         
Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe
        275                 280                 285             
Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp
    290                 295                 300                 
Ile Glu Pro Asn Arg Thr Asp Asn Met Glu Asp Val Ile Asn Cys Gln
305                 310                 315                 320 
His Ser Met Ser Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly
                325                 330                 335     
Asp Gly Asp Tyr Pro Glu Phe Met Lys Thr Gly Ala Met Ile Pro Glu
            340                 345                 350         
Phe Ser Glu Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe
        355                 360                 365             
Ala Phe Ser Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val
    370                 375                 380                 
Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp
385                 390                 395                 400 
Ile Lys Leu Glu Tyr Asp Asp Pro Gln Ile Leu Ile Ser Glu Asn Gly
                405                 410                 415     
Trp Phe Thr Asp Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr
            420                 425                 430         
Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp
        435                 440                 445             
Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe
    450                 455                 460                 
Glu Trp Gln Asp Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp
465                 470                 475                 480 
Phe Asn Ser Glu Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr
                485                 490                 495     
Tyr Lys Gln Ile Ile Gln Asp Asn Gly Phe Ser Leu Lys Glu Ser Thr
            500                 505                 510         
Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr
        515                 520                 525             
Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser
    530                 535                 540                 
Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His
545                 550                 555                 560 
Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp
                565                 570                 575     
Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val
            580                 585                 590         
Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly
        595                 600                 605             
Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val
    610                 615                 620                 
Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr
625                 630                 635                 640 
Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala
                645                 650                 655     
Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala
            660                 665                 670         
Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr
        675                 680                 685             
Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn
    690                 695                 700                 
Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala
705                 710                 715                 720 
Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val
                725                 730                 735     
Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala
            740                 745                 750         
Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala
        755                 760                 765             
Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met
    770                 775                 780                 
Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser Ala
785                 790                 795                 800 
Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr Val
                805                 810                 815     
Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His Glu
            820                 825                 830         
Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu
        835                 840                 845             
Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro
    850                 855                 860                 
Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp
865                 870                 875                 880 
Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu
                885                 890                 895     
Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val
            900                 905                 910         
Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala
        915                 920                 925             
Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr
    930                 935                 940                 
Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile
945                 950                 955                 960 
Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln
                965                 970                 975     
Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys
            980                 985                 990         
Lys Pro Leu Ile Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu
        995                 1000                1005            
Leu Leu Ser Ile Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp
    1010                1015                1020                
Lys Ala Lys Asn Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val
1025                1030                1035                1040
Val Ser
        


<210> 182
<211> 3129
<212> DNA
<213> Artificial Sequence

<220> 
<223> encoding sequence of mouse/human beta klotho chimeric protein

<400> 182
atgaagacag gctgtgcagc agggtctccg gggaatgaat ggattttctt cagctctgat 60
gaaagaaaca cacgctctag gaaaacaatg tccaacaggg cactgcaaag atctgccgtg 120
ctgtctgcgt ttgttctgct gcgagctgtt accggcttct ccggagacgg gaaagcaata 180
tgggataaaa aacagtacgt gagtccggta aacccaagtc agctgttcct ctatgacact 240
ttccctaaaa acttttcctg gggcgttggg accggagcat ttcaagtgga agggagttgg 300
aagacagatg gaagaggacc ctcgatctgg gatcggtacg tctactcaca cctgagaggt 360
gtcaacggca cagacagatc cactgacagt tacatctttc tggaaaaaga cttgttggct 420
ctggattttt taggagtttc tttttatcag ttctcaatct cctggccacg gttgtttccc 480
aatggaacag tagcagcagt gaatgcgcaa ggtctccggt actaccgtgc acttctggac 540
tcgctggtac ttaggaatat cgagcccatt gttaccttgt accattggga tttgcctctg 600
acgctccagg aagaatatgg gggctggaaa aatgcaacta tgatagatct cttcaacgac 660
tatgccacat actgcttcca gacctttgga gaccgtgtca aatattggat tacaattcac 720
aacccttacc ttgttgcttg gcatgggttt ggcacaggta tgcatgcacc aggagagaag 780
ggaaatttaa cagctgtcta cactgtggga cacaacctga tcaaggcaca ttcgaaagtg 840
tggcataact acgacaaaaa cttccgccct catcagaagg gttggctctc catcaccttg 900
gggtcccatt ggatagagcc aaacagaaca gacaacatgg aggacgtgat caactgccag 960
cactccatgt cctctgtgct tggatggttc gccaacccca tccacgggga cggcgactac 1020
cctgagttca tgaagacggg cgccatgatc cccgagttct ctgaggcaga gaaggaggag 1080
gtgaggggca cggctgattt ctttgccttt tccttcgggc ccaacaactt caggccctca 1140
aacaccgtgg tgaaaatggg acaaaatgta tcactcaact taaggcaggt gctgaactgg 1200
attaaactgg aatacgatga ccctcaaatc ttgatttcgg agaacggctg gttcacagat 1260
agctatataa agacagagga caccacggcc atctacatga tgaagaattt cctaaaccag 1320
gttcttcaag caataaaatt tgatgaaatc cgcgtgtttg gttatacggc ctggactctc 1380
ctggatggct ttgagtggca ggatgcctat acgacccgac gagggctgtt ttatgtggac 1440
tttaacagtg agcagaaaga gaggaaaccc aagtcctcgg ctcattacta caagcagatc 1500
atacaagaca acggcttctc tttaaaagag tccacgccag atgtgcaggg ccagtttccc 1560
tgtgacttct cctggggtgt cactgaatct gttcttaagc ccgagtctgt ggcttcgtcc 1620
ccacagttca gcgatcctca tctgtacgtg tggaacgcca ctggcaacag actgttgcac 1680
cgagtggaag gggtgaggct gaaaacacga cccgctcaat gcacagattt tgtaaacatc 1740
aaaaaacaac ttgagatgtt ggcaagaatg aaagtcaccc actaccggtt tgctctggat 1800
tgggcctcgg tccttcccac tggcaacctg tccgcggtga accgacaggc cctgaggtac 1860
tacaggtgcg tggtcagtga ggggctgaag cttggcatct ccgcgatggt caccctgtat 1920
tatccgaccc acgcccacct aggcctcccc gagcctctgt tgcatgccga cgggtggctg 1980
aacccatcga cggccgaggc cttccaggcc tacgctgggc tgtgcttcca ggagctgggg 2040
gacctggtga agctctggat caccatcaac gagcctaacc ggctaagtga catctacaac 2100
cgctctggca acgacaccta cggggcggcg cacaacctgc tggtggccca cgccctggcc 2160
tggcgcctct acgaccggca gttcaggccc tcacagcgcg gggccgtgtc gctgtcgctg 2220
cacgcggact gggcggaacc cgccaacccc tatgctgact cgcactggag ggcggccgag 2280
cgcttcctgc agttcgagat cgcctggttc gccgagccgc tcttcaagac cggggactac 2340
cccgcggcca tgagggaata cattgcctcc aagcaccgac gggggctttc cagctcggcc 2400
ctgccgcgcc tcaccgaggc cgaaaggagg ctgctcaagg gcacggtcga cttctgcgcg 2460
ctcaaccact tcaccactag gttcgtgatg cacgagcagc tggccggcag ccgctacgac 2520
tcggacaggg acatccagtt tctgcaggac atcacccgcc tgagctcccc cacgcgcctg 2580
gctgtgattc cctggggggt gcgcaagctg ctgcggtggg tccggaggaa ctacggcgac 2640
atggacattt acatcaccgc cagtggcatc gacgaccagg ctctggagga tgaccggctc 2700
cggaagtact acctagggaa gtaccttcag gaggtgctga aagcatacct gattgataaa 2760
gtcagaatca aaggctatta tgcattcaaa ctggctgaag agaaatctaa acccagattt 2820
ggattcttca catctgattt taaagctaaa tcctcaatac aattttacaa caaagtgatc 2880
agcagcaggg gcttcccttt tgagaacagt agttctagat gcagtcagac ccaagaaaat 2940
acagagtgca ctgtctgctt attccttgtg cagaagaaac cactgatatt cctgggttgt 3000
tgcttcttct ccaccctggt tctactctta tcaattgcca tttttcaaag gcagaagaga 3060
agaaagtttt ggaaagcaaa aaacttacaa cacataccat taaagaaagg caagagagtt 3120
gttagctag                                                         3129

<210> 183
<211> 209
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length mature form FGF21

<400> 183
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser
 1               5                  10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 184
<211> 630
<212> DNA
<213> Artificial Sequence

<220> 
<223> full length mature form FGF21

<400> 184
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt 60
cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc 120
gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac 180
ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc 240
ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg 300
ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc 360
tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac 420
ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga 480
ccagctcgct tcctgccact accaggcctg ccccccgcac ccccggagcc acccggaatc 540
ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc 600
cagggccgaa gccccagcta cgcttcctga                                  630

<210> 185
<211> 209
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length mature form FGF21

<400> 185
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser
 1               5                  10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 186
<211> 630
<212> DNA
<213> Artificial Sequence

<220> 
<223> full length mature form FGF21

<400> 186
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt 60
cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc 120
gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac 180
ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc 240
ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg 300
ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc 360
tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac 420
ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga 480
ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc 540
ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc 600
cagggccgaa gccccagcta cgcttcctga                                  630

<210> 187
<211> 651
<212> DNA
<213> Artificial Sequence

<220> 
<223> full length mature form of FGF19

<400> 187
atgcggagcg ggtgtgtggt ggtccacgta tggatcctgg ccggcctctg gctggccgtg 60
gccgggcgcc ccctcgcctt ctcggacgcg gggccccacg tgcactacgg ctggggcgac 120
cccatccgcc tgcggcacct gtacacctcc ggcccccacg ggctctccag ctgcttcctg 180
cgcatccgtg ccgacggcgt cgtggactgc gcgcggggcc agagcgcgca cagtttgctg 240
gagatcaagg cagtcgctct gcggaccgtg gccatcaagg gcgtgcacag cgtgcggtac 300
ctctgcatgg gcgccgacgg caagatgcag gggctgcttc agtactcgga ggaagactgt 360
gctttcgagg aggagatccg cccagatggc tacaatgtgt accgatccga gaagcaccgc 420
ctcccggtct ccctgagcag tgccaaacag cggcagctgt acaagaacag aggctttctt 480
ccactctctc atttcctgcc catgctgccc atggtcccag aggagcctga ggacctcagg 540
ggccacttgg aatctgacat gttctcttcg cccctggaga ccgacagcat ggacccattt 600
gggcttgtca ccggactgga ggccgtgagg agtcccagct ttgagaagta a          651

<210> 188
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length mature form of FGF19

<400> 188
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu
 1               5                  10                  15      
Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
            20                  25                  30          
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr
        35                  40                  45              
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala
    50                  55                  60                  
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu
65                  70                  75                  80  
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His
                85                  90                  95      
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu
            100                 105                 110         
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro
        115                 120                 125             
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser
    130                 135                 140                 
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu
145                 150                 155                 160 
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro
                165                 170                 175     
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu
            180                 185                 190         
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
        195                 200                 205             
Val Arg Ser Pro Ser Phe Glu Lys
    210                 215     


<210> 189
<211> 2469
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR1c (GenBank Accession Number NM 023110; also 
designated FGFR-alpha IIIc)

<400> 189
atgtggagct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac actctgcacc 60
gctaggccgt ccccgacctt gcctgaacaa gcccagccct ggggagcccc tgtggaagtg 120
gagtccttcc tggtccaccc cggtgacctg ctgcagcttc gctgtcggct gcgggacgat 180
gtgcagagca tcaactggct gcgggacggg gtgcagctgg cggaaagcaa ccgcacccgc 240
atcacagggg aggaggtgga ggtgcaggac tccgtgcccg cagactccgg cctctatgct 300
tgcgtaacca gcagcccctc gggcagtgac accacctact tctccgtcaa tgtttcagat 360
gctctcccct cctcggagga tgatgatgat gatgatgact cctcttcaga ggagaaagaa 420
acagataaca ccaaaccaaa ccgtatgccc gtagctccat attggacatc accagaaaag 480
atggaaaaga aattgcatgc agtgccggct gccaagacag tgaagttcaa atgcccttcc 540
agtgggacac caaacccaac actgcgctgg ttgaaaaatg gcaaagaatt caaacctgac 600
cacagaattg gaggctacaa ggtccgttat gccacctgga gcatcataat ggactctgtg 660
gtgccctctg acaagggcaa ctacacctgc attgtggaga atgagtacgg cagcatcaac 720
cacacatacc agctggatgt cgtggagcgg tcccctcacc ggcccatcct gcaagcaggg 780
ttgcccgcca acaaaacagt ggccctgggt agcaacgtgg agttcatgtg taaggtgtac 840
agtgacccgc agccgcacat ccagtggcta aagcacatcg aggtgaatgg gagcaagatt 900
ggcccagaca acctgcctta tgtccagatc ttgaagactg ctggagttaa taccaccgac 960
aaagagatgg aggtgcttca cttaagaaat gtctcctttg aggacgcagg ggagtatacg 1020
tgcttggcgg gtaactctat cggactctcc catcactctg catggttgac cgttctggaa 1080
gccctggaag agaggccggc agtgatgacc tcgcccctgt acctggagat catcatctat 1140
tgcacagggg ccttcctcat ctcctgcatg gtggggtcgg tcatcgtcta caagatgaag 1200
agtggtacca agaagagtga cttccacagc cagatggctg tgcacaagct ggccaagagc 1260
atccctctgc gcagacaggt aacagtgtct gctgactcca gtgcatccat gaactctggg 1320
gttcttctgg ttcggccatc acggctctcc tccagtggga ctcccatgct agcaggggtc 1380
tctgagtatg agcttcccga agaccctcgc tgggagctgc ctcgggacag actggtctta 1440
ggcaaacccc tgggagaggg ctgctttggg caggtggtgt tggcagaggc tatcgggctg 1500
gacaaggaca aacccaaccg tgtgaccaaa gtggctgtga agatgttgaa gtcggacgca 1560
acagagaaag acttgtcaga cctgatctca gaaatggaga tgatgaagat gatcgggaag 1620
cataagaata tcatcaacct gctgggggcc tgcacgcagg atggtccctt gtatgtcatc 1680
gtggagtatg cctccaaggg caacctgcgg gagtacctgc aggcccggag gcccccaggg 1740
ctggaatact gctacaaccc cagccacaac ccagaggagc agctctcctc caaggacctg 1800
gtgtcctgcg cctaccaggt ggcccgaggc atggagtatc tggcctccaa gaagtgcata 1860
caccgagacc tggcagccag gaatgtcctg gtgacagagg acaatgtgat gaagatagca 1920
gactttggcc tcgcacggga cattcaccac atcgactact ataaaaagac aaccaacggc 1980
cgactgcctg tgaagtggat ggcacccgag gcattatttg accggatcta cacccaccag 2040
agtgatgtgt ggtctttcgg ggtgctcctg tgggagatct tcactctggg cggctcccca 2100
taccccggtg tgcctgtgga ggaacttttc aagctgctga aggagggtca ccgcatggac 2160
aagcccagta actgcaccaa cgagctgtac atgatgatgc gggactgctg gcatgcagtg 2220
ccctcacaga gacccacctt caagcagctg gtggaagacc tggaccgcat cgtggccttg 2280
acctccaacc aggagtacct ggacctgtcc atgcccctgg accagtactc ccccagcttt 2340
cccgacaccc ggagctctac gtgctcctca ggggaggatt ccgtcttctc tcatgagccg 2400
ctgcccgagg agccctgcct gccccgacac ccagcccagc ttgccaatgg cggactcaaa 2460
cgccgctga                                                         2469

<210> 190
<211> 822
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR1c (GenBank Accession Number NM 023110; also 
designated FGFR-alpha IIIc)

<400> 190
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr
    130                 135                 140                 
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys
145                 150                 155                 160 
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe
                165                 170                 175     
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys
            180                 185                 190         
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val
        195                 200                 205             
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp
    210                 215                 220                 
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn
225                 230                 235                 240 
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile
                245                 250                 255     
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn
            260                 265                 270         
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln
        275                 280                 285             
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn
    290                 295                 300                 
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp
305                 310                 315                 320 
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala
                325                 330                 335     
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His
            340                 345                 350         
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val
        355                 360                 365             
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala
    370                 375                 380                 
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys
385                 390                 395                 400 
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys
                405                 410                 415     
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp
            420                 425                 430         
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg
        435                 440                 445             
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu
    450                 455                 460                 
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu
465                 470                 475                 480 
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu
                485                 490                 495     
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala
            500                 505                 510         
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu
        515                 520                 525             
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile
    530                 535                 540                 
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile
545                 550                 555                 560 
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg
                565                 570                 575     
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu
            580                 585                 590         
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala
        595                 600                 605             
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu
    610                 615                 620                 
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala
625                 630                 635                 640 
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys
                645                 650                 655     
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu
            660                 665                 670         
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val
        675                 680                 685             
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val
    690                 695                 700                 
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp
705                 710                 715                 720 
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys
                725                 730                 735     
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu
            740                 745                 750         
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp
        755                 760                 765             
Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg
    770                 775                 780                 
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro
785                 790                 795                 800 
Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn
                805                 810                 815     
Gly Gly Leu Lys Arg Arg
            820         


<210> 191
<211> 374
<212> PRT
<213> Artificial Sequence

<220> 
<223> example of an extracellular region of FGFR1c

<400> 191
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala
 1               5                  10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr
    130                 135                 140                 
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys
145                 150                 155                 160 
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe
                165                 170                 175     
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys
            180                 185                 190         
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val
        195                 200                 205             
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp
    210                 215                 220                 
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn
225                 230                 235                 240 
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile
                245                 250                 255     
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn
            260                 265                 270         
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln
        275                 280                 285             
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn
    290                 295                 300                 
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp
305                 310                 315                 320 
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala
                325                 330                 335     
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His
            340                 345                 350         
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val
        355                 360                 365             
Met Thr Ser Pro Leu Tyr
    370                 


<210> 192
<211> 354
<212> PRT
<213> Artificial Sequence

<220> 
<223> example of an extracellular region of FGFR1c (alpha-IIIc)

<400> 192
Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro
 1               5                  10                  15      
Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu
            20                  25                  30          
Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp
        35                  40                  45              
Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu
    50                  55                  60                  
Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys
65                  70                  75                  80  
Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn
                85                  90                  95      
Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp
            100                 105                 110         
Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met
        115                 120                 125             
Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu
    130                 135                 140                 
His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser
145                 150                 155                 160 
Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe
                165                 170                 175     
Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp
            180                 185                 190         
Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr
        195                 200                 205             
Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu
    210                 215                 220                 
Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu
225                 230                 235                 240 
Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys
                245                 250                 255     
Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile
            260                 265                 270         
Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln
        275                 280                 285             
Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val
    290                 295                 300                 
Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys
305                 310                 315                 320 
Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr
                325                 330                 335     
Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu
            340                 345                 350         
Tyr Glu
        


<210> 193
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> example of an extracellular region of FGFR1c (beta IIIc) 

<400> 193
Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu
 1               5                  10                  15      
Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp
            20                  25                  30          
Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys
        35                  40                  45              
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe
    50                  55                  60                  
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys
65                  70                  75                  80  
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val
                85                  90                  95      
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp
            100                 105                 110         
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn
        115                 120                 125             
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile
    130                 135                 140                 
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn
145                 150                 155                 160 
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln
                165                 170                 175     
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn
            180                 185                 190         
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp
        195                 200                 205             
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala
    210                 215                 220                 
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His
225                 230                 235                 240 
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val
                245                 250                 255     
Met Thr Ser Pro Leu Tyr Leu Glu
            260                 


<210> 194
<211> 2466
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR2c

<400> 194
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60
gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc 120
aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg 180
cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg 240
cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga 300
gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc 360
atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg 420
gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa 480
aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca 540
gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag 600
gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt 660
gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg agaatgaata cgggtccatc 720
aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc 780
ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt 840
tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa 900
tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg 960
gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat 1020
acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg 1080
ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt 1140
tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg 1200
aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa 1260
cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc 1320
aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg 1380
gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag 1440
ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca 1500
gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa 1560
gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg 1620
attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc 1680
tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg 1740
ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc 1800
aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa 1860
aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg 1920
aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc 1980
accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac 2040
actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg 2100
ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac 2160
agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg 2220
catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt 2280
ctcactctca caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca 2340
cctagttacc ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca 2400
gaccccatgc cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa 2460
acatga                                                            2466

<210> 195
<211> 821
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR2c

<400> 195
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala
 1               5                  10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu
        355                 360                 365             
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly
    370                 375                 380                 
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met
385                 390                 395                 400 
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His
                405                 410                 415     
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala
            420                 425                 430         
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr
        435                 440                 445             
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser
    450                 455                 460                 
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys
465                 470                 475                 480 
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val
                485                 490                 495     
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val
            500                 505                 510         
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu
        515                 520                 525             
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His
    530                 535                 540                 
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu
545                 550                 555                 560 
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu
                565                 570                 575     
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg
            580                 585                 590         
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr
        595                 600                 605             
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His
    610                 615                 620                 
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met
625                 630                 635                 640 
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr
                645                 650                 655     
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro
            660                 665                 670         
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser
        675                 680                 685             
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr
    690                 695                 700                 
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His
705                 710                 715                 720 
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met
                725                 730                 735     
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln
            740                 745                 750         
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu
        755                 760                 765             
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro
    770                 775                 780                 
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro
785                 790                 795                 800 
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn
                805                 810                 815     
Gly Ser Val Lys Thr
            820     


<210> 196
<211> 2421
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR3c (GenBank Accession Number NP 000133)

<400> 196
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc 60
tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc 120
ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc 180
tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg 240
ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc 300
cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac 360
ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag 420
gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac 480
aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc 540
aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc 600
attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc 660
tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg 720
tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg 780
gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac 840
gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg 900
gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag 960
ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg 1020
gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag 1080
gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg 1140
gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc 1200
ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag 1260
cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc 1320
gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct 1380
gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag 1440
ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc 1500
aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg 1560
gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac 1620
ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag 1680
ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac 1740
acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag 1800
gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc 1860
cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg 1920
gacgtgcaca acctcgacta ctacaagaag acaaccaacg gccggctgcc cgtgaagtgg 1980
atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt 2040
ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg 2100
gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca 2160
cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc 2220
ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgagtac 2280
ctggacctgt cggcgccttt cgagcagtac tccccgggtg gccaggacac ccccagctcc 2340
agctcctcag gggacgactc cgtgtttgcc cacgacctgc tgcccccggc cccacccagc 2400
agtgggggct cgcggacgtg a                                           2421

<210> 197
<211> 806
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR3c

<400> 197
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 198
<211> 2409
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR4c

<400> 198
atgcggctgc tgctggccct gttgggggtc ctgctgagtg tgcctgggcc tccagtcttg 60
tccctggagg cctctgagga agtggagctt gagccctgcc tggctcccag cctggagcag 120
caagagcagg agctgacagt agcccttggg cagcctgtgc gtctgtgctg tgggcgggct 180
gagcgtggtg gccactggta caaggagggc agtcgcctgg cacctgctgg ccgtgtacgg 240
ggctggaggg gccgcctaga gattgccagc ttcctacctg aggatgctgg ccgctacctc 300
tgcctggcac gaggctccat gatcgtcctg cagaatctca ccttgattac aggtgactcc 360
ttgacctcca gcaacgatga tgaggacccc aagtcccata gggacccctc gaataggcac 420
agttaccccc agcaagcacc ctactggaca cacccccagc gcatggagaa gaaactgcat 480
gcagtacctg cggggaacac cgtcaagttc cgctgtccag ctgcaggcaa ccccacgccc 540
accatccgct ggcttaagga tggacaggcc tttcatgggg agaaccgcat tggaggcatt 600
cggctgcgcc atcagcactg gagtctcgtg atggagagcg tggtgccctc ggaccgcggc 660
acatacacct gcctggtaga gaacgctgtg ggcagcatcc gctataacta cctgctagat 720
gtgctggagc ggtccccgca ccggcccatc ctgcaggccg ggctcccggc caacaccaca 780
gccgtggtgg gcagcgacgt ggagctgctg tgcaaggtgt acagcgatgc ccagccccac 840
atccagtggc tgaagcacat cgtcatcaac ggcagcagct tcggagccga cggtttcccc 900
tatgtgcaag tcctaaagac tgcagacatc aatagctcag aggtggaggt cctgtacctg 960
cggaacgtgt cagccgagga cgcaggcgag tacacctgcc tcgcaggcaa ttccatcggc 1020
ctctcctacc agtctgcctg gctcacggtg ctgccagagg aggaccccac atggaccgca 1080
gcagcgcccg aggccaggta tacggacatc atcctgtacg cgtcgggctc cctggccttg 1140
gctgtgctcc tgctgctggc cgggctgtat cgagggcagg cgctccacgg ccggcacccc 1200
cgcccgcccg ccactgtgca gaagctctcc cgcttccctc tggcccgaca gttctccctg 1260
gagtcaggct cttccggcaa gtcaagctca tccctggtac gaggcgtgcg tctctcctcc 1320
agcggccccg ccttgctcgc cggcctcgtg agtctagatc tacctctcga cccactatgg 1380
gagttccccc gggacaggct ggtgcttggg aagcccctag gcgagggctg ctttggccag 1440
gtagtacgtg cagaggcctt tggcatggac cctgcccggc ctgaccaagc cagcactgtg 1500
gccgtcaaga tgctcaaaga caacgcctct gacaaggacc tggccgacct ggtctcggag 1560
atggaggtga tgaagctgat cggccgacac aagaacatca tcaacctgct tggtgtctgc 1620
acccaggaag ggcccctgta cgtgatcgtg gagtgcgccg ccaagggaaa cctgcgggag 1680
ttcctgcggg cccggcgccc cccaggcccc gacctcagcc ccgacggtcc tcggagcagt 1740
gaggggccgc tctccttccc agtcctggtc tcctgcgcct accaggtggc ccgaggcatg 1800
cagtatctgg agtcccggaa gtgtatccac cgggacctgg ctgcccgcaa tgtgctggtg 1860
actgaggaca atgtgatgaa gattgctgac tttgggctgg cccgcggcgt ccaccacatt 1920
gactactata agaaaaccag caacggccgc ctgcctgtga agtggatggc gcccgaggcc 1980
ttgtttgacc gggtgtacac acaccagagt gacgtgtggt cttttgggat cctgctatgg 2040
gagatcttca ccctcggggg ctccccgtat cctggcatcc cggtggagga gctgttctcg 2100
ctgctgcggg agggacatcg gatggaccga cccccacact gccccccaga gctgtacggg 2160
ctgatgcgtg agtgctggca cgcagcgccc tcccagaggc ctaccttcaa gcagctggtg 2220
gaggcgctgg acaaggtcct gctggccgtc tctgaggagt acctcgacct ccgcctgacc 2280
ttcggaccct attccccctc tggtggggac gccagcagca cctgctcctc cagcgattct 2340
gtcttcagcc acgaccccct gccattggga tccagctcct tccccttcgg gtctggggtg 2400
cagacatga                                                         2409

<210> 199
<211> 802
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR4 (GenBank Accession Number NP. 002002.3)

<400> 199
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly
 1               5                  10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro
            340                 345                 350         
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr
        355                 360                 365             
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu
    370                 375                 380                 
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro
385                 390                 395                 400 
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg
                405                 410                 415     
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu
            420                 425                 430         
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly
        435                 440                 445             
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg
    450                 455                 460                 
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln
465                 470                 475                 480 
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln
                485                 490                 495     
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys
            500                 505                 510         
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly
        515                 520                 525             
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly
    530                 535                 540                 
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu
545                 550                 555                 560 
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly
                565                 570                 575     
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys
            580                 585                 590         
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys
        595                 600                 605             
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn
    610                 615                 620                 
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile
625                 630                 635                 640 
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met
                645                 650                 655     
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val
            660                 665                 670         
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser
        675                 680                 685             
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu
    690                 695                 700                 
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly
705                 710                 715                 720 
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe
                725                 730                 735     
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu
            740                 745                 750         
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly
        755                 760                 765             
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His
    770                 775                 780                 
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val
785                 790                 795                 800 
Gln Thr
        


<210> 200
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified human IgG1 Fc sequence

<400> 200
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 201
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 201
Gln Gln Lys Pro Gly Lys Ala Pro Lys
 1               5                  


<210> 202
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 202
Gln Arg Lys Pro Gly Lys Ala Pro Lys
 1               5                  


<210> 203
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 203
Gln Gln Lys Gln Gly Lys Ala Pro Lys
 1               5                  


<210> 204
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 204
Gln Gln Lys Pro Gly Lys Ser Pro Lys
 1               5                  


<210> 205
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 205
Gln Gln Lys Pro Gly Lys Ala Pro Gln
 1               5                  


<210> 206
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 206
Gln Gln Lys Gln Gly Lys Ser Pro Lys
 1               5                  


<210> 207
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-c VH domain

<400> 207
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 208
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 208
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10              


<210> 209
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 209
Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10              


<210> 210
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 210
Gln Gln Lys Gln Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10              


<210> 211
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 211
Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10              


<210> 212
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 212
Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile Tyr
 1               5                  10              


<210> 213
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 213
Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10              


<210> 214
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-d VH domain

<400> 214
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 215
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 215
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ile Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 216
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-e VH domain

<400> 216
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 217
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR2 of Humanized Anti-Beta Klotho Antibodies

<400> 217
Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 218
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 218
Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 219
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 219
Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 220
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-f VH domain

<400> 220
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 221
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-g VH domain

<400> 221
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 222
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 222
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 223
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 223
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 224
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 224
Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 225
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 225
Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 226
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 226
Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 227
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VH FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 227
Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 228
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 228
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 229
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 229
Gly Met Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 230
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 230
Gly Met Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 231
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 231
Gly Met Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Thr
 1               5                  10                  15      
Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 232
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary VL FR3 of Humanized Anti-Beta Klotho Antibodies

<400> 232
Gly Met Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 233
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-h VH domain

<400> 233
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 234
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-i VH domain

<400> 234
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 235
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-j VH domain

<400> 235
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 236
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-k VH domain

<400> 236
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 237
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-l VH domain

<400> 237
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 238
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-m VH domain

<400> 238
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 239
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-n VH domain

<400> 239
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 240
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-o VH domain

<400> 240
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 241
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-p VH domain

<400> 241
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 242
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-q VH domain

<400> 242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 243
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-r VH domain

<400> 243
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 244
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-s VH domain

<400> 244
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ile Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 245
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-t VH domain

<400> 245
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 246
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-u VH domain

<400> 246
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 247
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-v VH domain

<400> 247
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 248
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-w VH domain

<400> 248
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 249
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-HC-336-x VH domain

<400> 249
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Asn Ile Asp Pro Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 250
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21 VL domain

<400> 250
Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 251
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-a VL domain

<400> 251
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 252
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-b VL domain

<400> 252
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 253
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-c VL domain

<400> 253
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 254
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-d VL domain

<400> 254
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 255
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-e VL domain

<400> 255
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 256
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-f VL domain

<400> 256
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 257
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-g VL domain

<400> 257
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 258
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-h VL domain

<400> 258
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 259
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-i VL domain

<400> 259
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 260
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-j VL domain

<400> 260
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 261
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-k VL domain

<400> 261
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 262
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-l VL domain

<400> 262
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 263
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-m VL domain

<400> 263
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 264
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-n VL domain

<400> 264
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 265
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-o VL domain

<400> 265
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 266
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-p VL domain

<400> 266
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 267
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m2J21-LC-336-q VL domain

<400> 267
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Tyr Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 268
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2 VH domain

<400> 268
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120         


<210> 269
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-a VH domain

<400> 269
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 270
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-b VH domain

<400> 270
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 271
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-c VH domain

<400> 271
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 272
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-d VH domain

<400> 272
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 273
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-e VH domain

<400> 273
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 274
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-f VH domain

<400> 274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 275
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-g VH domain

<400> 275
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 276
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-h VH domain

<400> 276
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 277
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-i VH domain

<400> 277
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 278
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-j VH domain

<400> 278
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 279
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-k VH domain

<400> 279
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 280
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-l VH domain

<400> 280
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 281
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-m VH domain

<400> 281
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 282
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-n VH domain

<400> 282
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 283
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-o VH domain

<400> 283
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 284
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-p VH domain

<400> 284
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 285
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-q VH domain

<400> 285
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 286
<211> 474
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified 3I13-hIgG1(E233A)(L235A)

<400> 286
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly
        35                  40                  45              
Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Gln Gly Leu Glu Trp Met Gly Ser Phe Asn Pro Asp Ser Gly Gly Thr
65                  70                  75                  80  
Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr
                85                  90                  95      
Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr
        115                 120                 125             
Trp Tyr Phe Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255     
Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    290                 295                 300                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
305                 310                 315                 320 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                325                 330                 335     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
            340                 345                 350         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        355                 360                 365             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
    370                 375                 380                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
385                 390                 395                 400 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                405                 410                 415     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            420                 425                 430         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        435                 440                 445             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    450                 455                 460                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 


<210> 287
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> chimeric construct of antibody 3I13

<400> 287
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Gly Ala Ser
        35                  40                  45              
Glu Asn Ile Tyr Gly Ala Leu Asn Trp Phe Gln Arg Lys Gln Gly Lys
    50                  55                  60                  
Ser Pro Gln Leu Leu Ile Tyr Gly Ala Thr Ile Leu Ala Asp Gly Met
65                  70                  75                  80  
Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys
                85                  90                  95      
Ile Ser Ser Leu His Pro Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn
            100                 105                 110         
Val Leu Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 288
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-r VH domain

<400> 288
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 289
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-s VH domain

<400> 289
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 290
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-t VH domain

<400> 290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 291
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-u VH domain

<400> 291
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 292
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-v VH domain

<400> 292
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 293
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-w VH domain

<400> 293
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr
            20                  25                  30          
Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Phe Asn Pro Asn Tyr Gly Gly Ala Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Gly Tyr Ser Thr Arg Tyr Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 294
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2 VL domain

<400> 294
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 295
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-a VL domain

<400> 295
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 296
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-b VL domain

<400> 296
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 297
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-c VL domain

<400> 297
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 298
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-d VL domain

<400> 298
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 299
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-e VL domain

<400> 299
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 300
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> exemplary kappa constant region

<400> 300
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 301
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-f VL domain

<400> 301
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 302
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-g VL domain

<400> 302
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 303
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-h VL domain

<400> 303
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 304
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-i VL domain

<400> 304
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 305
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-j VL domain

<400> 305
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 306
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-k VL domain

<400> 306
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 307
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-l VL domain

<400> 307
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 308
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-m VL domain

<400> 308
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 309
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-n VL domain

<400> 309
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 310
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-o VL domain

<400> 310
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Tyr Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 311
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-p VL domain

<400> 311
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 312
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-q VL domain

<400> 312
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 313
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> antibody m4A2-LC-337-r VL domain

<400> 313
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Arg Asp Tyr Thr Leu Lys Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         