                         SEQUENCE LISTING

<110>  University of Washington
 
<120>  MULTI-EPITOPE HSV UL39 VACCINE AND METHODS FOR USING SAME

<130>  UW.60WOU1

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  1137
<212>  PRT
<213>  herpes simplex virus 1

<400>  1

Met Ala Ser Arg Pro Ala Ala Ser Ser Pro Val Glu Ala Arg Ala Pro 
1               5                   10                  15      


Val Gly Gly Gln Glu Ala Gly Gly Pro Ser Ala Ala Thr Gln Gly Glu 
            20                  25                  30          


Ala Ala Gly Ala Pro Leu Ala His Gly His His Val Tyr Cys Gln Arg 
        35                  40                  45              


Val Asn Gly Val Met Val Leu Ser Asp Lys Thr Pro Gly Ser Ala Ser 
    50                  55                  60                  


Tyr Arg Ile Ser Asp Asn Asn Phe Val Gln Cys Gly Ser Asn Cys Thr 
65                  70                  75                  80  


Met Ile Ile Asp Gly Asp Val Val Arg Gly Arg Pro Gln Asp Pro Gly 
                85                  90                  95      


Ala Ala Ala Ser Pro Ala Pro Phe Val Ala Val Thr Asn Ile Gly Ala 
            100                 105                 110         


Gly Ser Asp Gly Gly Thr Ala Val Val Ala Phe Gly Gly Thr Pro Arg 
        115                 120                 125             


Arg Ser Ala Gly Thr Ser Thr Gly Thr Gln Thr Ala Asp Val Pro Thr 
    130                 135                 140                 


Glu Ala Leu Gly Gly Pro Pro Pro Pro Pro Arg Phe Thr Leu Gly Gly 
145                 150                 155                 160 


Gly Cys Cys Ser Cys Arg Asp Thr Arg Arg Arg Ser Ala Val Phe Gly 
                165                 170                 175     


Gly Glu Gly Asp Pro Val Gly Pro Ala Glu Phe Val Ser Asp Asp Arg 
            180                 185                 190         


Ser Ser Asp Ser Asp Ser Asp Asp Ser Glu Asp Thr Asp Ser Glu Thr 
        195                 200                 205             


Leu Ser His Ala Ser Ser Asp Val Ser Gly Gly Ala Thr Tyr Asp Asp 
    210                 215                 220                 


Ala Leu Asp Ser Asp Ser Ser Ser Asp Asp Ser Leu Gln Ile Asp Gly 
225                 230                 235                 240 


Pro Val Cys Arg Pro Trp Ser Asn Asp Thr Ala Pro Leu Asp Val Cys 
                245                 250                 255     


Pro Gly Thr Pro Gly Pro Gly Ala Asp Ala Gly Gly Pro Ser Ala Val 
            260                 265                 270         


Asp Pro His Ala Pro Thr Pro Glu Ala Gly Ala Gly Leu Ala Ala Asp 
        275                 280                 285             


Pro Ala Val Ala Arg Asp Asp Ala Glu Gly Leu Ser Asp Pro Arg Pro 
    290                 295                 300                 


Arg Leu Gly Thr Gly Thr Ala Tyr Pro Val Pro Leu Glu Leu Thr Pro 
305                 310                 315                 320 


Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asn Arg 
                325                 330                 335     


Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu 
            340                 345                 350         


Thr Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Pro Pro Arg Leu Thr 
        355                 360                 365             


Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Leu Val Glu Met Gln Arg 
    370                 375                 380                 


Leu Cys Leu Asp Val Pro Pro Val Pro Pro Asn Ala Tyr Met Pro Tyr 
385                 390                 395                 400 


Tyr Leu Arg Glu Tyr Val Thr Arg Leu Val Asn Gly Phe Lys Pro Leu 
                405                 410                 415     


Val Ser Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly Val Leu Val His 
            420                 425                 430         


Leu Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Leu Arg Ser 
        435                 440                 445             


Lys Glu Val Ala Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His 
    450                 455                 460                 


Glu Ala Gln Leu Val Ile Leu Ala Gln Ala Leu Asp His Tyr Asp Cys 
465                 470                 475                 480 


Leu Ile His Ser Thr Pro His Thr Leu Val Glu Arg Gly Leu Gln Ser 
                485                 490                 495     


Ala Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr 
            500                 505                 510         


Met Glu Ser Val Phe Gln Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala 
        515                 520                 525             


Cys Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Glu Gly 
    530                 535                 540                 


Ser Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His 
545                 550                 555                 560 


Gln Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn 
                565                 570                 575     


Tyr Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gln Ala Thr Thr Asn 
            580                 585                 590         


Lys Ala Thr Leu Arg Ala Ile Thr Ser Asn Val Ser Ala Ile Leu Ala 
        595                 600                 605             


Arg Asn Gly Gly Ile Gly Leu Cys Val Gln Ala Phe Asn Asp Ser Gly 
    610                 615                 620                 


Pro Gly Thr Ala Ser Val Met Pro Ala Leu Lys Val Leu Asp Ser Leu 
625                 630                 635                 640 


Val Ala Ala His Asn Lys Glu Ser Ala Arg Pro Thr Gly Ala Cys Val 
                645                 650                 655     


Tyr Leu Glu Pro Trp His Thr Asp Val Arg Ala Val Leu Arg Met Lys 
            660                 665                 670         


Gly Val Leu Ala Gly Glu Glu Ala Gln Arg Cys Asp Asn Ile Phe Ser 
        675                 680                 685             


Ala Leu Trp Met Pro Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu 
    690                 695                 700                 


Asp Gly Glu Lys Asn Val Thr Trp Thr Leu Phe Asp Arg Asp Thr Ser 
705                 710                 715                 720 


Met Ser Leu Ala Asp Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Gln 
                725                 730                 735     


His Leu Glu Val Met Gly Phe Gly Glu Gln Ile Pro Ile Gln Glu Leu 
            740                 745                 750         


Ala Tyr Gly Ile Val Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Val 
        755                 760                 765             


Met Phe Lys Asp Ala Val Asn Arg His Tyr Ile Tyr Asp Thr Gln Gly 
    770                 775                 780                 


Ala Ala Ile Ala Gly Ser Asn Leu Cys Thr Glu Ile Val His Pro Ala 
785                 790                 795                 800 


Ser Lys Arg Ser Ser Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala 
                805                 810                 815     


Arg Cys Val Ser Arg Gln Thr Phe Asp Phe Gly Arg Leu Arg Asp Ala 
            820                 825                 830         


Val Gln Ala Cys Val Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu 
        835                 840                 845             


Gln Pro Thr Pro Gln Cys Thr Arg Gly Asn Asp Asn Leu Arg Ser Met 
    850                 855                 860                 


Gly Ile Gly Met Gln Gly Leu His Thr Ala Cys Leu Lys Leu Gly Leu 
865                 870                 875                 880 


Asp Leu Glu Ser Ala Glu Phe Gln Asp Leu Asn Lys His Ile Ala Glu 
                885                 890                 895     


Val Met Leu Leu Ser Ala Met Lys Thr Ser Asn Ala Leu Cys Val Arg 
            900                 905                 910         


Gly Ala Arg Pro Phe Asn His Phe Lys Arg Ser Met Tyr Arg Ala Gly 
        915                 920                 925             


Arg Phe His Trp Glu Arg Phe Pro Asp Ala Arg Pro Arg Tyr Glu Gly 
    930                 935                 940                 


Glu Trp Glu Met Leu Arg Gln Ser Met Met Lys His Gly Leu Arg Asn 
945                 950                 955                 960 


Ser Gln Phe Val Ala Leu Met Pro Thr Ala Ala Ser Ala Gln Ile Ser 
                965                 970                 975     


Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu Phe Ser Lys 
            980                 985                 990         


Val Thr Arg Asp Gly Glu Thr Leu  Arg Pro Asn Thr Leu  Leu Leu Lys 
        995                 1000                 1005             


Glu Leu  Glu Arg Thr Phe Ser  Gly Lys Arg Leu Leu  Glu Val Met 
    1010                 1015                 1020             


Asp Ser  Leu Asp Ala Lys Gln  Trp Ser Val Ala Gln  Ala Leu Pro 
    1025                 1030                 1035             


Cys Leu  Glu Pro Thr His Pro  Leu Arg Arg Phe Lys  Thr Ala Phe 
    1040                 1045                 1050             


Asp Tyr  Asp Gln Lys Leu Leu  Ile Asp Leu Cys Ala  Asp Arg Ala 
    1055                 1060                 1065             


Pro Tyr  Val Asp His Ser Gln  Ser Met Thr Leu Tyr  Val Thr Glu 
    1070                 1075                 1080             


Lys Ala  Asp Gly Thr Leu Pro  Ala Ser Thr Leu Val  Arg Leu Leu 
    1085                 1090                 1095             


Val His  Ala Tyr Lys Arg Gly  Leu Lys Thr Gly Met  Tyr Tyr Cys 
    1100                 1105                 1110             


Lys Val  Arg Lys Ala Thr Asn  Ser Gly Val Phe Gly  Gly Asp Asp 
    1115                 1120                 1125             


Asn Ile  Val Cys Met Ser Cys  Ala Leu 
    1130                 1135         


<210>  2
<211>  718
<212>  PRT
<213>  herpes simplex virus 1

<400>  2

Met Gln Arg Arg Thr Arg Gly Ala Ser Ser Leu Arg Leu Ala Arg Cys 
1               5                   10                  15      


Leu Thr Pro Ala Asn Leu Ile Arg Gly Asp Asn Ala Gly Val Pro Glu 
            20                  25                  30          


Arg Arg Ile Phe Gly Gly Cys Leu Leu Pro Thr Pro Glu Gly Leu Leu 
        35                  40                  45              


Ser Ala Ala Val Gly Ala Leu Arg Gln Arg Ser Asp Asp Ala Gln Pro 
    50                  55                  60                  


Ala Phe Leu Thr Cys Thr Asp Arg Ser Val Arg Leu Ala Ala Arg Gln 
65                  70                  75                  80  


His Asn Thr Val Pro Glu Ser Leu Ile Val Asp Gly Leu Ala Ser Asp 
                85                  90                  95      


Pro His Tyr Glu Tyr Ile Arg His Tyr Ala Ser Ala Ala Thr Gln Ala 
            100                 105                 110         


Leu Gly Glu Val Glu Leu Pro Gly Gly Gln Leu Ser Arg Ala Ile Leu 
        115                 120                 125             


Thr Gln Tyr Trp Lys Tyr Leu Gln Thr Val Val Pro Ser Gly Leu Asp 
    130                 135                 140                 


Val Pro Glu Asp Pro Val Gly Asp Cys Asp Pro Ser Leu His Val Leu 
145                 150                 155                 160 


Leu Arg Pro Thr Leu Ala Pro Lys Leu Leu Ala Arg Thr Pro Phe Lys 
                165                 170                 175     


Ser Gly Ala Val Ala Ala Lys Tyr Ala Ala Thr Val Ala Gly Leu Arg 
            180                 185                 190         


Asp Ala Leu His Arg Ile Gln Gln Tyr Met Phe Phe Met Arg Pro Ala 
        195                 200                 205             


Asp Pro Ser Arg Pro Ser Thr Asp Thr Ala Leu Arg Leu Asn Glu Leu 
    210                 215                 220                 


Leu Ala Tyr Val Ser Val Leu Tyr Arg Trp Ala Ser Trp Met Leu Trp 
225                 230                 235                 240 


Thr Thr Asp Lys His Val Cys His Arg Leu Ser Pro Ser Asn Arg Arg 
                245                 250                 255     


Phe Leu Pro Leu Gly Gly Ser Pro Glu Ala Pro Ala Glu Thr Phe Ala 
            260                 265                 270         


Arg His Leu Asp Arg Gly Pro Ser Gly Thr Thr Gly Ser Met Gln Cys 
        275                 280                 285             


Met Ala Leu Arg Ala Ala Val Ser Asp Val Leu Gly His Leu Thr Arg 
    290                 295                 300                 


Leu Ala Asn Leu Trp Gln Thr Gly Lys Arg Ser Gly Gly Thr Tyr Gly 
305                 310                 315                 320 


Thr Val Asp Thr Val Val Ser Thr Val Glu Val Leu Ser Ile Val His 
                325                 330                 335     


His His Ala Gln Tyr Ile Ile Asn Ala Thr Leu Thr Gly Tyr Gly Val 
            340                 345                 350         


Trp Ala Thr Asp Ser Leu Asn Asn Glu Tyr Leu Arg Ala Ala Val Asp 
        355                 360                 365             


Ser Gln Glu Arg Phe Cys Arg Thr Thr Ala Pro Leu Phe Pro Thr Met 
    370                 375                 380                 


Thr Ala Pro Ser Trp Ala Arg Met Glu Leu Ser Ile Lys Ala Trp Phe 
385                 390                 395                 400 


Gly Ala Ala Leu Ala Ala Asp Leu Leu Arg Asn Gly Ala Pro Ser Leu 
                405                 410                 415     


His Tyr Glu Ser Ile Leu Arg Leu Val Ala Ser Arg Arg Thr Thr Trp 
            420                 425                 430         


Ser Ala Gly Pro Pro Pro Asp Asp Met Ala Ser Gly Pro Gly Gly His 
        435                 440                 445             


Arg Ala Gly Gly Gly Thr Cys Arg Glu Lys Ile Gln Arg Ala Arg Arg 
    450                 455                 460                 


Asp Asn Glu Pro Pro Pro Leu Pro Arg Pro Arg Leu His Ser Thr Pro 
465                 470                 475                 480 


Ala Ser Thr Arg Arg Phe Arg Arg Arg Arg Ala Asp Gly Ala Gly Pro 
                485                 490                 495     


Pro Leu Pro Asp Ala Asn Asp Pro Val Ala Glu Pro Pro Ala Ala Ala 
            500                 505                 510         


Thr Gln Pro Ala Thr Tyr Tyr Thr His Met Gly Glu Val Pro Pro Arg 
        515                 520                 525             


Leu Pro Ala Arg Asn Val Ala Gly Pro Asp Arg Arg Pro Pro Ala Ala 
    530                 535                 540                 


Thr Cys Pro Leu Leu Val Arg Arg Ala Ser Leu Gly Ser Leu Asp Arg 
545                 550                 555                 560 


Pro Arg Val Trp Gly Pro Ala Pro Glu Gly Glu Pro Asp Gln Met Glu 
                565                 570                 575     


Ala Thr Tyr Leu Thr Ala Asp Asp Asp Asp Asp Asp Ala Arg Arg Lys 
            580                 585                 590         


Ala Thr His Ala Ala Ser Ala Arg Glu Arg His Ala Pro Tyr Glu Asp 
        595                 600                 605             


Asp Glu Ser Ile Tyr Glu Thr Val Ser Glu Asp Gly Gly Arg Val Tyr 
    610                 615                 620                 


Glu Glu Ile Pro Trp Met Arg Val Tyr Glu Asn Val Cys Val Asn Thr 
625                 630                 635                 640 


Ala Asn Ala Ala Pro Ala Ser Pro Tyr Ile Glu Ala Glu Asn Pro Leu 
                645                 650                 655     


Tyr Asp Trp Gly Gly Ser Ala Leu Phe Ser Pro Pro Gly Arg Thr Gly 
            660                 665                 670         


Pro Pro Pro Pro Pro Leu Ser Pro Ser Pro Val Leu Ala Arg His Arg 
        675                 680                 685             


Ala Asn Ala Leu Thr Asn Asp Gly Pro Thr Asn Val Ala Ala Leu Ser 
    690                 695                 700                 


Ala Leu Leu Thr Lys Leu Lys Arg Glu Gly Arg Arg Ser Arg 
705                 710                 715             


<210>  3
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  3

Ser Ser Asp Val Ser Gly Gly Ala Thr Tyr 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  4

Tyr Met Glu Ser Val Phe Gln Met Tyr 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  5

Arg Leu Tyr Arg Ile Leu Gly Val Leu Val 
1               5                   10  


<210>  6
<211>  12
<212>  PRT
<213>  herpes simplex virus

<400>  6

Arg Leu Tyr Arg Ile Leu Gly Val Ile Val His Leu 
1               5                   10          


<210>  7
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  7

Leu Val Asn Pro Gln Ala Thr Thr Asn Lys 
1               5                   10  


<210>  8
<211>  11
<212>  PRT
<213>  herpes simplex virus 1

<400>  8

Ala Met Lys Thr Ser Asn Ala Leu Cys Val Arg 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  9

Arg Ile Arg Thr Arg Glu Ala Ser Phe 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  10

Glu Ile Val His Pro Ala Ser Lys Arg 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  11

Glu Ile Val His Pro Ser Cys Lys Arg 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  12

Arg Pro Thr Gly Ala Cys Val Tyr Leu 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  herpes simplex virus 1

<400>  13

Gly Thr Ala Tyr Pro Val Pro Leu 
1               5               


<210>  14
<211>  12
<212>  PRT
<213>  herpes simplex virus 1

<400>  14

Arg Leu Tyr Arg Ile Leu Gly Val Leu Val His Leu 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  herpes simplex virus 1

<400>  15

Arg Leu Tyr Arg Ile Leu Gly Val Ile Val His 
1               5                   10      


<210>  16
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  16

Thr Leu Phe Asp Arg Asp Thr Ser Met 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  17

Ser Leu Phe Asp Arg Asp Thr Ser Met 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  herpes simplex virus 1

<400>  18

Gln His Leu Glu Val Met Gly Phe 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  herpes simplex virus 1

<400>  19

Glu His Leu Glu Ala Met Gly Phe 
1               5               


<210>  20
<211>  11
<212>  PRT
<213>  herpes simplex virus 1

<400>  20

Phe Gln Met Tyr Thr Arg Ile Ala Gly Phe Leu 
1               5                   10      


<210>  21
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  21

Thr Arg Ile Ala Gly Phe Leu Ala Cys 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  22

Gln Arg Cys Asp Asn Ile Phe Ser Ala 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  23

Gln Arg Cys Asp Asn Ile Phe Ser Ala Leu 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  24

Arg Glu His Glu Ala Gln Leu Val Ile Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  25

Arg Glu His Glu Ala Gln Leu Met Ile Leu 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  26

Gly Glu Gln Ile Pro Ile Gln Glu Leu 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  herpes simplex virus 1

<400>  27

Gly Glu Thr Ile Pro Ile Gln Asp Leu 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  herpes simplex virus 1

<400>  28

Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp 
1               5                   10  


<210>  29
<211>  8
<212>  PRT
<213>  herpes simplex virus 1

<400>  29

Arg Glu Ala Ser Phe Glu Glu Trp 
1               5               


<210>  30
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  30

Trp Leu Arg Ser Lys Glu Val Ala Leu Asp Phe Gly Leu 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  31

Glu Ala Gln Leu Val Ile Leu Ala Gln Ala Leu Asp His 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  32

Val Ile Leu Ala Gln Ala Leu Asp His Tyr Asp Cys Leu 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  33

Lys Ala Thr Leu Arg Ala Ile Thr Ser Asn Val Ser Ala 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  34

Pro Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu Asp 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  35

Phe Lys Arg Leu Ile Arg His Leu Asp Gly Glu Lys Asn 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  36

His Tyr Ile Tyr Asp Thr Gln Gly Ala Ala Ile Ala Gly 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  37

Ser Gln Phe Val Ala Leu Met Pro Thr Ala Ala Ser Ala 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  38

Ala Leu Met Pro Thr Ala Ala Ser Ala Gln Ile Ser Asp 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  herpes simplex virus 1

<400>  39

Thr Ala Ala Ser Ala Gln Ile Ser Asp Val Ser Glu Gly 
1               5                   10              


