                         SEQUENCE LISTING

<110>  GlaxoSmithkline Intellectual Property Development Limited
 
<120>  Codon Optimised Tet Repressor Proteins

<130>  PB65938P

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  624
<212>  DNA
<213>  E.coli

<400>  1
atgtctagat tagataaaag taaagtgatt aacagcgcat tagagctgct taatgaggtc       60

ggaatcgaag gtttaacaac ccgtaaactc gcccagaagc taggtgtaga gcagcctaca      120

ttgtattggc atgtaaaaaa taagcgggct ttgctcgacg ccttagccat tgagatgtta      180

gataggcacc atactcactt ttgcccttta gaaggggaaa gctggcaaga ttttttacgt      240

aataacgcta aaagttttag atgtgcttta ctaagtcatc gcgatggagc aaaagtacat      300

ttaggtacac ggcctacaga aaaacagtat gaaactctcg aaaatcaatt agccttttta      360

tgccaacaag gtttttcact agagaatgca ttatatgcac tcagcgctgt ggggcatttt      420

actttaggtt gcgtattgga agatcaagag catcaagtcg ctaaagaaga aagggaaaca      480

cctactactg atagtatgcc gccattatta cgacaagcta tcgaattatt tgatcaccaa      540

ggtgcagagc cagccttctt attcggcctt gaattgatca tatgcggatt agaaaaacaa      600

cttaaatgtg aaagtgggtc ttaa                                             624


<210>  2
<211>  207
<212>  PRT
<213>  E.coli

<400>  2

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  3
<211>  624
<212>  DNA
<213>  E.coli

<400>  3
atgtctaggc tggacaagtc caaggtgatc aactccgccc tggagctcct taacgaggtg       60

gggattgaag ggttgactac ccggaaactg gctcagaaac tgggcgtcga acagccaacc      120

ctgtactggc acgtgaagaa caagcgcgct ttgctggatg cacttgccat cgagatgctg      180

gacaggcacc acacacactt ttgccccttg gagggcgaat cctggcagga cttcctgagg      240

aacaacgcca agagtttccg ctgtgccctg ttgagtcaca gggacggagc aaaggttcac      300

cttggaacca gacccaccga gaagcagtac gagactctgg agaaccagct ggccttcctg      360

tgtcagcagg gctttagcct ggagaacgct ctgtacgcac tgtctgccgt tggccacttt      420

acactcggat gcgtgctgga agaccaggag catcaggttg ccaaggaaga gagggagacc      480

cctaccactg acagcatgcc tccacttctg agacaggcca tcgagctctt tgaccaccag      540

ggagcagaac ccgctttcct cttcgggctg gaactgatca tctgcggcct cgaaaagcag      600

ctcaagtgcg aaagcggcag ctga                                             624


<210>  4
<211>  624
<212>  DNA
<213>  E.coli

<400>  4
atgagcaggc tggacaagag caaggtgatc aacagcgccc tggagctgct gaacgaggtc       60

ggcatcgagg gcctgacaac caggaagctg gcccagaaac tcggagtgga gcagcccacc      120

ctgtactggc acgtgaagaa caagcgcgcc ctcctggacg ccctggctat tgagatgctg      180

gacaggcacc acacccactt ctgcccactg gagggcgaga gctggcagga cttcctgagg      240

aacaacgcca agagcttcag gtgtgccctg ctgagccata gggacggcgc caaggtgcac      300

ctgggcacca ggcccaccga gaagcagtac gagaccctgg agaaccagct ggccttcctc      360

tgccagcagg gcttcagcct ggagaatgca ctgtacgccc tgagcgccgt gggccacttc      420

accctggggt gcgtgctgga agaccaggaa caccaggtgg ccaaggagga gagggagacc      480

cccaccaccg actctatgcc ccccctgctg aggcaggcca tcgaactgtt cgatcaccag      540

ggcgccgagc ccgcctttct gttcggcctg gagctgatca tctgcggcct ggagaagcag      600

ctgaagtgcg agagcggctc ctga                                             624


<210>  5
<211>  657
<212>  DNA
<213>  E.coli

<400>  5
atgtctagat tagataaaag taaagtgatt aacagcgcat tagagctgct taatgaggtc       60

ggaatcgaag gtttaacaac ccgtaaactc gcccagaagc taggtgtaga gcagcctaca      120

ttgtattggc atgtaaaaaa taagcgggct ttgctcgacg ccttagccat tgagatgtta      180

gataggcacc atactcactt ttgcccttta gaaggggaaa gctggcaaga ttttttacgt      240

aataacgcta aaagttttag atgtgcttta ctaagtcatc gcgatggagc aaaagtacat      300

ttaggtacac ggcctacaga aaaacagtat gaaactctcg aaaatcaatt agccttttta      360

tgccaacaag gtttttcact agagaatgca ttatatgcac tcagcgctgt ggggcatttt      420

actttaggtt gcgtattgga agatcaagag catcaagtcg ctaaagaaga aagggaaaca      480

cctactactg atagtatgcc gccattatta cgacaagcta tcgaattatt tgatcaccaa      540

ggtgcagagc cagccttctt attcggcctt gaattgatca tatgcggatt agaaaaacaa      600

cttaaatgtg aaagtgggtc cgcgtacagc ggatcccggg aattcagatc ttattaa         657


<210>  6
<211>  674
<212>  DNA
<213>  E.coli

<400>  6
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accg                                                        674


<210>  7
<211>  727
<212>  DNA
<213>  E.coli

<400>  7
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggaacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctctc cctatcagtg      600

atagagatct ccctatcagt gatagagatc gtcgacgagc tcgtttagtg aaccgtcaga      660

tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca      720

gcctccg                                                                727


<210>  8
<211>  727
<212>  DNA
<213>  E.coli

<400>  8
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggaacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctctc cctatcagtg      600

atagagatct ccctatcagt gatagagatc gtcgacgagc tcgtttagtg aaccgtcaga      660

tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca      720

gcctccg                                                                727


