                         SEQUENCE LISTING

<110>  SiDanSai Biotechnology CO.,LTD
      
<120>  HUMANIZED ANTI-CD19 ANTIBODY AND USE THEREOF

<130>  I151061PCT

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Mouse

<400>  1

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  107
<212>  PRT
<213>  Mouse

<400>  2

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc catcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattacct gactatggtg taagctggat tcgccagcct      120

ccacgcaagg gtctggagtg gctgggagta atctggggta gtgaaaccac atactataat      180

tcagctctca aatcccgcct gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  6
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga ccgcgtcacc       60

atcagttgcc gtgcaagtca ggacattagt aaatacttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcacgct tacactcagg agtcccatca      180

cggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggactaagt tggaaatcaa a                                                321


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
1               5                   10  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser 
            20                  25  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
            20                  25                  30      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Gly Val Ser Leu Pro Asp Tyr Gly 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Ile Trp Gly Ser Glu Thr Thr 
1               5           


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser 
            20                  25  


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  15      


Val 
    


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
1               5                   10                  15      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys Ala 
        35                  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  22
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
1               5                   10                  15      


Thr Val Ser Ser 
            20  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28
caggtgcaac tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggggt ctcattacca gactatggtt ggagctggat tcggcagccg      120

ccggggaagg gactggagtg gattgggcgt atctggggta gtgaaaccac atactacaac      180

ccgtccctca agagtcgcgt caccatttcc gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcagacacg gctgtgtatt actgtgcgaa acattattac      300

tacggtggta gctatgctat ggactactgg ggccaaggaa ccctggtcac cgtctcctca      360


<210>  29
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29
caggtgcaac tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggggt ctcattacca gactatggtg tgagctggat tcggcagccg      120

ccggggaagg gactggagtg gattggggtt atctggggta gtgaaaccac atactacaac      180

agcgccctca agagtcgcgt caccatttcc gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcagacacg gctgtgtatt actgtgcgaa acattattac      300

tacggtggta gctatgctat ggactactgg ggccaaggaa ccctggtcac cgtctcctca      360


<210>  30
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  30
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggagt gtccctgcct gattatggcg tgtcctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcagtg atctggggca gcgagacaac ctactacaac      180

agcgccctga agtcccgatt caccatctcc agagacaatg ccaagaactc actgtatctg      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgaa gcactactac      300

tacggcggca gctacgctat ggactactgg ggccaaggaa ccctggtcac cgtctcctca      360


<210>  31
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  31
gatatccaga tgacccagag cccgagcagc ctgagcgcga gcgtgggtga tcgcgtgacc       60

attacctgcc gcgcgagcca gagtgtcggt agcttcctgg cttggtatca gcagaaaccg      120

ggtaaagcgc cgaaactgtt aatttatggt gccagcagcc gggagtctgg cgtgccgtcg      180

cgttttagcg gctcgggttc gggcaccgat tttaccctga ccatctcgag cttgcagccg      240

gaggacttcg ccacctacta ttgccagcaa acctaccata acccagagac cttcggtcag      300

ggcaccaaag tggagatcaa a                                                321


<210>  32
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  32
agctacgaac tgacccagcc gccgagcgtg tcggtggcgc cgggtcagac cgcgcgtatc       60

acctgcggcg gcaacgacct ccgtgcccag tatgtccatt ggtatcagca gaaaccgggt      120

caggcaccgg tgctggtgat gtacgacgat agtaagcgcc cgtctggcat cccggaacgc      180

tttagcggct cgaattcggg caacaccgcg accctgacca ttagcggcac ccaggcggag      240

gatgaggcgg actattactg ccagtcatgg gacaggacga gcgaacctaa ggtgtttggc      300

ggtggcacca aactgaccgt gcta                                             324


<210>  33
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  33
agctacgaac tgacccagcc gccgagcgtg tcggtggcgc cgggtcagac cgcgcgtatc       60

acctgcggcg gcaacaacct tggtgacaac tctgctcgtt ggtatcagca gaaaccgggt      120

caggcaccgg tgctggtgat ttacggcaac agtaatcgcc cgtctggcat cccggaacgt      180

tttagcggct cgaattcggg caacaccgcg accctgacca ttagcggcac ccaggcggag      240

gatgaggcgg actattactg ccaggtgacg gacacaagaa gcacatctgt ggtgtttggc      300

ggtggcacca aactgaccgt gcta                                             324


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr His Asn Pro Glu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asp Leu Arg Ala Gln Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
        35                  40                  45              


Asp Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Arg Thr Ser Glu Pro 
                85                  90                  95      


Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  36
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Asp Asn Ser Ala 
            20                  25                  30          


Arg Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asn Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Thr Asp Thr Arg Ser Thr Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


