                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
 
<120>  HIGH-THROUGHPUT SCREENING OF REGULATORY ELEMENT FUNCTION WITH 
       EPIGENOME EDITING TECHNOLOGIES

<130>  028193-9198-WO00

<140>  PCT/US2016/043756
<141>  2016-07-22

<150>  62/195,680
<151>  2015-07-22

<150>  62/293,313
<151>  2016-02-09

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  2048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210>  3
<211>  1521
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Ala  Ser Asp Ala Lys Ser  Leu Thr Ala Trp Ser  Arg Thr Leu 
    1415                 1420                 1425             


Val Thr  Phe Lys Asp Val Phe  Val Asp Phe Thr Arg  Glu Glu Trp 
    1430                 1435                 1440             


Lys Leu  Leu Asp Thr Ala Gln  Gln Ile Leu Tyr Arg  Asn Val Met 
    1445                 1450                 1455             


Leu Glu  Asn Tyr Lys Asn Leu  Val Ser Leu Gly Tyr  Gln Leu Thr 
    1460                 1465                 1470             


Lys Pro  Asp Val Ile Leu Arg  Leu Glu Lys Gly Glu  Glu Pro Trp 
    1475                 1480                 1485             


Leu Val  Glu Arg Glu Ile His  Gln Glu Thr His Pro  Asp Ser Glu 
    1490                 1495                 1500             


Thr Ala  Phe Glu Ile Lys Ser  Ser Val Pro Lys Lys  Lys Arg Lys 
    1505                 1510                 1515             


Val Ala  Ser 
    1520     


<210>  4
<211>  617
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4

Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu 
1               5                   10                  15      


Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn 
            20                  25                  30          


Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg 
        35                  40                  45              


Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys 
    50                  55                  60                  


Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val 
65                  70                  75                  80  


Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu 
                85                  90                  95      


Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys 
            100                 105                 110         


Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala 
        115                 120                 125             


Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys 
    130                 135                 140                 


Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser 
145                 150                 155                 160 


Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 
                165                 170                 175     


Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 
            180                 185                 190         


Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu 
        195                 200                 205             


Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu 
    210                 215                 220                 


Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn 
225                 230                 235                 240 


Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu 
                245                 250                 255     


Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp 
            260                 265                 270         


Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys 
        275                 280                 285             


Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr 
    290                 295                 300                 


Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp 
305                 310                 315                 320 


Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile 
                325                 330                 335     


His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln 
            340                 345                 350         


Leu Gly Gly Asp Pro Ile Ala Gly Ser Lys Ala Ser Pro Lys Lys Lys 
        355                 360                 365             


Arg Lys Val Gly Arg Ala Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala 
    370                 375                 380                 


Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu 
385                 390                 395                 400 


Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr 
                405                 410                 415     


Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg Lys 
            420                 425                 430         


Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile 
        435                 440                 445             


Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg 
    450                 455                 460                 


Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu Ile 
465                 470                 475                 480 


Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu 
                485                 490                 495     


Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile 
            500                 505                 510         


Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys 
        515                 520                 525             


Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly Asp 
    530                 535                 540                 


Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys 
545                 550                 555                 560 


Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr Glu 
                565                 570                 575     


Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile Ile 
            580                 585                 590         


Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg 
        595                 600                 605             


Thr Arg Lys Glu Asn Lys Phe Ser Ala 
    610                 615         


<210>  5
<211>  1726
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Ala 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Ala Ala Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Ala Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg Ser 
    1070                 1075                 1080             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val Glu Ala  Ser Gly Arg 
    1085                 1090                 1095             


Ala Ile  Phe Lys Pro Glu Glu  Leu Arg Gln Ala Leu  Met Pro Thr 
    1100                 1105                 1110             


Leu Glu  Ala Leu Tyr Arg Gln  Asp Pro Glu Ser Leu  Pro Phe Arg 
    1115                 1120                 1125             


Gln Pro  Val Asp Pro Gln Leu  Leu Gly Ile Pro Asp  Tyr Phe Asp 
    1130                 1135                 1140             


Ile Val  Lys Ser Pro Met Asp  Leu Ser Thr Ile Lys  Arg Lys Leu 
    1145                 1150                 1155             


Asp Thr  Gly Gln Tyr Gln Glu  Pro Trp Gln Tyr Val  Asp Asp Ile 
    1160                 1165                 1170             


Trp Leu  Met Phe Asn Asn Ala  Trp Leu Tyr Asn Arg  Lys Thr Ser 
    1175                 1180                 1185             


Arg Val  Tyr Lys Tyr Cys Ser  Lys Leu Ser Glu Val  Phe Glu Gln 
    1190                 1195                 1200             


Glu Ile  Asp Pro Val Met Gln  Ser Leu Gly Tyr Cys  Cys Gly Arg 
    1205                 1210                 1215             


Lys Leu  Glu Phe Ser Pro Gln  Thr Leu Cys Cys Tyr  Gly Lys Gln 
    1220                 1225                 1230             


Leu Cys  Thr Ile Pro Arg Asp  Ala Thr Tyr Tyr Ser  Tyr Gln Asn 
    1235                 1240                 1245             


Arg Tyr  His Phe Cys Glu Lys  Cys Phe Asn Glu Ile  Gln Gly Glu 
    1250                 1255                 1260             


Ser Val  Ser Leu Gly Asp Asp  Pro Ser Gln Pro Gln  Thr Thr Ile 
    1265                 1270                 1275             


Asn Lys  Glu Gln Phe Ser Lys  Arg Lys Asn Asp Thr  Leu Asp Pro 
    1280                 1285                 1290             


Glu Leu  Phe Val Glu Cys Thr  Glu Cys Gly Arg Lys  Met His Gln 
    1295                 1300                 1305             


Ile Cys  Val Leu His His Glu  Ile Ile Trp Pro Ala  Gly Phe Val 
    1310                 1315                 1320             


Cys Asp  Gly Cys Leu Lys Lys  Ser Ala Arg Thr Arg  Lys Glu Asn 
    1325                 1330                 1335             


Lys Phe  Ser Ala Lys Arg Leu  Pro Ser Thr Arg Leu  Gly Thr Phe 
    1340                 1345                 1350             


Leu Glu  Asn Arg Val Asn Asp  Phe Leu Arg Arg Gln  Asn His Pro 
    1355                 1360                 1365             


Glu Ser  Gly Glu Val Thr Val  Arg Val Val His Ala  Ser Asp Lys 
    1370                 1375                 1380             


Thr Val  Glu Val Lys Pro Gly  Met Lys Ala Arg Phe  Val Asp Ser 
    1385                 1390                 1395             


Gly Glu  Met Ala Glu Ser Phe  Pro Tyr Arg Thr Lys  Ala Leu Phe 
    1400                 1405                 1410             


Ala Phe  Glu Glu Ile Asp Gly  Val Asp Leu Cys Phe  Phe Gly Met 
    1415                 1420                 1425             


His Val  Gln Glu Tyr Gly Ser  Asp Cys Pro Pro Pro  Asn Gln Arg 
    1430                 1435                 1440             


Arg Val  Tyr Ile Ser Tyr Leu  Asp Ser Val His Phe  Phe Arg Pro 
    1445                 1450                 1455             


Lys Cys  Leu Arg Thr Ala Val  Tyr His Glu Ile Leu  Ile Gly Tyr 
    1460                 1465                 1470             


Leu Glu  Tyr Val Lys Lys Leu  Gly Tyr Thr Thr Gly  His Ile Trp 
    1475                 1480                 1485             


Ala Cys  Pro Pro Ser Glu Gly  Asp Asp Tyr Ile Phe  His Cys His 
    1490                 1495                 1500             


Pro Pro  Asp Gln Lys Ile Pro  Lys Pro Lys Arg Leu  Gln Glu Trp 
    1505                 1510                 1515             


Tyr Lys  Lys Met Leu Asp Lys  Ala Val Ser Glu Arg  Ile Val His 
    1520                 1525                 1530             


Asp Tyr  Lys Asp Ile Phe Lys  Gln Ala Thr Glu Asp  Arg Leu Thr 
    1535                 1540                 1545             


Ser Ala  Lys Glu Leu Pro Tyr  Phe Glu Gly Asp Phe  Trp Pro Asn 
    1550                 1555                 1560             


Val Leu  Glu Glu Ser Ile Lys  Glu Leu Glu Gln Glu  Glu Glu Glu 
    1565                 1570                 1575             


Arg Lys  Arg Glu Glu Asn Thr  Ser Asn Glu Ser Thr  Asp Val Thr 
    1580                 1585                 1590             


Lys Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1595                 1600                 1605             


Ser Lys  Asn Lys Ser Ser Leu  Ser Arg Gly Asn Lys  Lys Lys Pro 
    1610                 1615                 1620             


Gly Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1625                 1630                 1635             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  Arg Leu Ile 
    1640                 1645                 1650             


Ala Gly  Pro Ala Ala Asn Ser  Leu Pro Pro Ile Val  Asp Pro Asp 
    1655                 1660                 1665             


Pro Leu  Ile Pro Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1670                 1675                 1680             


Thr Leu  Ala Arg Asp Lys His  Leu Glu Phe Ser Ser  Leu Arg Arg 
    1685                 1690                 1695             


Ala Gln  Trp Ser Thr Met Cys  Met Leu Val Glu Leu  His Thr Gln 
    1700                 1705                 1710             


Ser Gln  Asp Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Ser 
    1715                 1720                 1725     


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6
caatgacccc ttcattgacc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7
ttgattttgg agggatctcg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8
agaccatgtc cgggaaaacc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
gccagcccga agtctgtaat                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10
gctgagtgaa ctgcactgtg a                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11
gaattctttg ccgaaatgga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12
tcactagcaa gctctcaggc                                                   20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13
aacaacgagg agtctgccc                                                    19


<210>  14
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14
ggcaaggctg gccaacccat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  15
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15
cggacctgac tccacccctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  16
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16
actatgctga gctgtgatga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  17
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17
tgccctgtaa gcatcctgct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  18
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18
ccatgagtag agggcagaca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  19
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
tactaggctg actcactcca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  20
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
ggtgcgtccc tcctagcgcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  21
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21
taccccggcg cccctcacca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  22
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22
ctttggcgca tgcttcaccc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  23
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23
aaggcctcaa acattcccct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  24
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24
gcgttaggtg gtgtggtcta gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  25
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25
gtgcctcccc cattccgctc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  26
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  26
ttcccacacc ccgttcctgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  27
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  27
aaccaggtgc ccacccgggc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  28
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  28
tcgcctgcag ccttacgggc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  29
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29
tccttggcta actccaggct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  30
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  30
cgcggcgccg ctctccgctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  31
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  31
agccgggtgt cctgacgctc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  32
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  32
gtttaattcg ggaagaatgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  33
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  33
agcgctcgat aaatacttac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  34
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  34
tgttgggcat taagagggag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  35
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35
catcgcggcc ggctccgctc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  36
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  36
tgacagcaat agtggcctac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  37
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  37
caggttagac ttacaaggtg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  38
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  38
ctactccttc ctcttgagac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  39
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  39
gggtgcgtcc ctcctagcgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  40
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  40
ggatgtactc cctggaagag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  41
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  41
gtagaaagtg gagctgagct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  42
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  42
tcaggcctga catcagacca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  43
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  43
gctggaggta tagaccactg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  44
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  44
gactgcagga ctgagctaag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  45
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  45
agggaccaag ctgctgggat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  46
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  46
gactgaggct acccctgctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  47
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  47
ttcctgatag cccttgaccg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  48
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  48
tgctagccag agcggaatgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  49
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  49
cgatggcgcg tcccctcgtg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


