                         SEQUENCE LISTING

<110>  Monsanto Technology LLC
  
<120>  Multi Functional Toxins

<130>  MONS:395WO

<150>  US 62/196,249
<151>  2015-07-23

<150>  US 62/328,543
<151>  2016-04-27

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1178
<212>  PRT
<213>  Bacillus thuringiensis

<400>  1

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Arg Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Tyr Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Ala Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Glu Phe Asn Asn 
    450                 455                 460                 


Ile Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly 
            500                 505                 510         


Tyr Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg 
        515                 520                 525             


Val Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn 
    530                 535                 540                 


Trp Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr 
545                 550                 555                 560 


Ser Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala 
                565                 570                 575     


Asn Ala Phe Thr Ser Ser Leu Gly Asn Ile Val Gly Val Arg Asn Phe 
            580                 585                 590         


Ser Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val 
        595                 600                 605             


Thr Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala 
    610                 615                 620                 


Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn 
625                 630                 635                 640 


Val Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu 
                645                 650                 655     


Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val 
            660                 665                 670         


Lys His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser 
        675                 680                 685             


Asn Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser 
    690                 695                 700                 


Thr Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr 
705                 710                 715                 720 


Val Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr 
                725                 730                 735     


Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu 
            740                 745                 750         


Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg 
        755                 760                 765             


Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu 
    770                 775                 780                 


Trp Pro Leu Ser Thr Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn 
785                 790                 795                 800 


Arg Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys 
                805                 810                 815     


Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp 
            820                 825                 830         


Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val 
        835                 840                 845             


Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu 
    850                 855                 860                 


Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val 
865                 870                 875                 880 


Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp 
                885                 890                 895     


Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu 
            900                 905                 910         


Phe Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala 
        915                 920                 925             


Met Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr 
    930                 935                 940                 


Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu 
945                 950                 955                 960 


Glu Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg 
                965                 970                 975     


Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn 
            980                 985                 990         


Val Lys Gly His Val Asp Val Glu  Glu Gln Asn Asn Gln  Arg Ser Val 
        995                 1000                 1005             


Leu Val  Val Pro Glu Trp Glu  Ala Glu Val Ser Gln  Glu Val Arg 
    1010                 1015                 1020             


Val Cys  Pro Gly Arg Gly Tyr  Ile Leu Arg Val Thr  Ala Tyr Lys 
    1025                 1030                 1035             


Glu Gly  Tyr Gly Glu Gly Cys  Val Thr Ile His Glu  Ile Glu Asn 
    1040                 1045                 1050             


Asn Thr  Asp Glu Leu Lys Phe  Ser Asn Cys Val Glu  Glu Glu Ile 
    1055                 1060                 1065             


Tyr Pro  Asn Asn Thr Val Thr  Cys Asn Asp Tyr Thr  Val Asn Gln 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Gly Ala Tyr  Thr Ser Arg Asn Arg  Gly Tyr Asn 
    1085                 1090                 1095             


Glu Ala  Pro Ser Val Pro Ala  Asp Tyr Ala Ser Val  Tyr Glu Glu 
    1100                 1105                 1110             


Lys Ser  Tyr Thr Asp Gly Arg  Arg Glu Asn Pro Cys  Glu Phe Asn 
    1115                 1120                 1125             


Arg Gly  Tyr Arg Asp Tyr Thr  Pro Leu Pro Val Gly  Tyr Val Thr 
    1130                 1135                 1140             


Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp Lys Val  Trp Ile Glu 
    1145                 1150                 1155             


Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val Asp Ser  Val Glu Leu 
    1160                 1165                 1170             


Leu Leu  Met Glu Glu 
    1175             


<210>  2
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Trp Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Arg Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Asn 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Tyr Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Glu Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Ile Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Lys Phe Ser Asn 
    450                 455                 460                 


Ile Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly 
            500                 505                 510         


Tyr Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg 
        515                 520                 525             


Val Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn 
    530                 535                 540                 


Trp Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr 
545                 550                 555                 560 


Ser Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala 
                565                 570                 575     


Asn Ala Phe Thr Ser Leu Leu Gly Asn Ile Val Gly Val Arg Asn Phe 
            580                 585                 590         


Ser Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val 
        595                 600                 605             


Thr Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala 
    610                 615                 620                 


Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn 
625                 630                 635                 640 


Val Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu 
                645                 650                 655     


Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val 
            660                 665                 670         


Lys His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser 
        675                 680                 685             


Asn Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser 
    690                 695                 700                 


Thr Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr 
705                 710                 715                 720 


Val Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr 
                725                 730                 735     


Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu 
            740                 745                 750         


Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg 
        755                 760                 765             


Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu 
    770                 775                 780                 


Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn 
785                 790                 795                 800 


Arg Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys 
                805                 810                 815     


Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp 
            820                 825                 830         


Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val 
        835                 840                 845             


Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu 
    850                 855                 860                 


Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val 
865                 870                 875                 880 


Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp 
                885                 890                 895     


Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu 
            900                 905                 910         


Phe Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala 
        915                 920                 925             


Met Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr 
    930                 935                 940                 


Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu 
945                 950                 955                 960 


Glu Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg 
                965                 970                 975     


Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn 
            980                 985                 990         


Val Lys Gly His Val Asp Val Glu  Glu Gln Asn Asn Gln  Arg Ser Val 
        995                 1000                 1005             


Leu Val  Val Pro Glu Trp Glu  Ala Glu Val Ser Gln  Glu Val Arg 
    1010                 1015                 1020             


Val Cys  Pro Gly Arg Gly Tyr  Ile Leu Arg Val Thr  Ala Tyr Lys 
    1025                 1030                 1035             


Glu Gly  Tyr Gly Glu Gly Cys  Val Thr Ile His Glu  Ile Glu Asn 
    1040                 1045                 1050             


Asn Thr  Asp Glu Leu Lys Phe  Ser Asn Cys Val Glu  Glu Glu Ile 
    1055                 1060                 1065             


Tyr Pro  Asn Asn Thr Val Thr  Cys Asn Asp Tyr Thr  Val Asn Gln 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Gly Ala Tyr  Thr Ser Arg Asn Arg  Gly Tyr Asn 
    1085                 1090                 1095             


Glu Ala  Pro Ser Val Pro Ala  Asp Tyr Ala Ser Val  Tyr Glu Glu 
    1100                 1105                 1110             


Lys Ser  Tyr Thr Asp Gly Arg  Arg Glu Asn Pro Cys  Glu Phe Asn 
    1115                 1120                 1125             


Arg Gly  Tyr Arg Asp Tyr Thr  Pro Leu Pro Val Gly  Tyr Val Thr 
    1130                 1135                 1140             


Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp Lys Val  Trp Ile Glu 
    1145                 1150                 1155             


Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val Asp Ser  Val Glu Leu 
    1160                 1165                 1170             


Leu Leu  Met Glu Glu 
    1175             


<210>  3
<211>  1178
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  3

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Trp Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Ser Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Asp Ile Glu 
        275                 280                 285             


Arg Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Asn 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Tyr Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Lys Ala Ser Pro Val Gly Phe Ser Gly Pro Gly Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Glu Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


His Leu Gly Gln Gly Val Tyr Arg Ile Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Lys Phe Ser Asn 
    450                 455                 460                 


Ile Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly 
            500                 505                 510         


Tyr Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg 
        515                 520                 525             


Val Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn 
    530                 535                 540                 


Trp Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr 
545                 550                 555                 560 


Ser Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala 
                565                 570                 575     


Asn Ala Phe Thr Ser Leu Leu Gly Asn Ile Val Gly Val Arg Asn Phe 
            580                 585                 590         


Ser Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val 
        595                 600                 605             


Thr Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala 
    610                 615                 620                 


Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn 
625                 630                 635                 640 


Val Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu 
                645                 650                 655     


Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val 
            660                 665                 670         


Lys His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser 
        675                 680                 685             


Asn Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser 
    690                 695                 700                 


Thr Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr 
705                 710                 715                 720 


Val Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr 
                725                 730                 735     


Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu 
            740                 745                 750         


Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg 
        755                 760                 765             


Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu 
    770                 775                 780                 


Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn 
785                 790                 795                 800 


Arg Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys 
                805                 810                 815     


Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp 
            820                 825                 830         


Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val 
        835                 840                 845             


Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu 
    850                 855                 860                 


Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val 
865                 870                 875                 880 


Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp 
                885                 890                 895     


Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu 
            900                 905                 910         


Phe Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala 
        915                 920                 925             


Met Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr 
    930                 935                 940                 


Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu 
945                 950                 955                 960 


Glu Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg 
                965                 970                 975     


Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn 
            980                 985                 990         


Val Lys Gly His Val Asp Val Glu  Glu Gln Asn Asn Gln  Arg Ser Val 
        995                 1000                 1005             


Leu Val  Val Pro Glu Trp Glu  Ala Glu Val Ser Gln  Glu Val Arg 
    1010                 1015                 1020             


Val Cys  Pro Gly Arg Gly Tyr  Ile Leu Arg Val Thr  Ala Tyr Lys 
    1025                 1030                 1035             


Glu Gly  Tyr Gly Glu Gly Cys  Val Thr Ile His Glu  Ile Glu Asn 
    1040                 1045                 1050             


Asn Thr  Asp Glu Leu Lys Phe  Ser Asn Cys Val Glu  Glu Glu Ile 
    1055                 1060                 1065             


Tyr Pro  Asn Asn Thr Val Thr  Cys Asn Asp Tyr Thr  Val Asn Gln 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Gly Ala Tyr  Thr Ser Arg Asn Arg  Gly Tyr Asn 
    1085                 1090                 1095             


Glu Ala  Pro Ser Val Pro Ala  Asp Tyr Ala Ser Val  Tyr Glu Glu 
    1100                 1105                 1110             


Lys Ser  Tyr Thr Asp Gly Arg  Arg Glu Asn Pro Cys  Glu Phe Asn 
    1115                 1120                 1125             


Arg Gly  Tyr Arg Asp Tyr Thr  Pro Leu Pro Val Gly  Tyr Val Thr 
    1130                 1135                 1140             


Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp Lys Val  Trp Ile Glu 
    1145                 1150                 1155             


Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val Asp Ser  Val Glu Leu 
    1160                 1165                 1170             


Leu Leu  Met Glu Glu 
    1175             


<210>  4
<211>  1178
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  4

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Trp Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Arg Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Asn 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Tyr Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Lys Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Glu Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


His Leu Gly Gln Gly Val Tyr Arg Ile Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Lys Phe Ser Asn 
    450                 455                 460                 


Ile Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn 
465                 470                 475                 480 


Phe Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly 
            500                 505                 510         


Tyr Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg 
        515                 520                 525             


Val Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn 
    530                 535                 540                 


Trp Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr 
545                 550                 555                 560 


Ser Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala 
                565                 570                 575     


Asn Ala Phe Thr Ser Leu Leu Gly Asn Ile Val Gly Val Arg Asn Phe 
            580                 585                 590         


Ser Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val 
        595                 600                 605             


Thr Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala 
    610                 615                 620                 


Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn 
625                 630                 635                 640 


Val Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu 
                645                 650                 655     


Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val 
            660                 665                 670         


Lys His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser 
        675                 680                 685             


Asn Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser 
    690                 695                 700                 


Thr Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr 
705                 710                 715                 720 


Val Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr 
                725                 730                 735     


Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu 
            740                 745                 750         


Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg 
        755                 760                 765             


Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu 
    770                 775                 780                 


Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn 
785                 790                 795                 800 


Arg Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys 
                805                 810                 815     


Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp 
            820                 825                 830         


Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val 
        835                 840                 845             


Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu 
    850                 855                 860                 


Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val 
865                 870                 875                 880 


Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp 
                885                 890                 895     


Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu 
            900                 905                 910         


Phe Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala 
        915                 920                 925             


Met Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr 
    930                 935                 940                 


Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu 
945                 950                 955                 960 


Glu Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg 
                965                 970                 975     


Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn 
            980                 985                 990         


Val Lys Gly His Val Asp Val Glu  Glu Gln Asn Asn Gln  Arg Ser Val 
        995                 1000                 1005             


Leu Val  Val Pro Glu Trp Glu  Ala Glu Val Ser Gln  Glu Val Arg 
    1010                 1015                 1020             


Val Cys  Pro Gly Arg Gly Tyr  Ile Leu Arg Val Thr  Ala Tyr Lys 
    1025                 1030                 1035             


Glu Gly  Tyr Gly Glu Gly Cys  Val Thr Ile His Glu  Ile Glu Asn 
    1040                 1045                 1050             


Asn Thr  Asp Glu Leu Lys Phe  Ser Asn Cys Val Glu  Glu Glu Ile 
    1055                 1060                 1065             


Tyr Pro  Asn Asn Thr Val Thr  Cys Asn Asp Tyr Thr  Val Asn Gln 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Gly Ala Tyr  Thr Ser Arg Asn Arg  Gly Tyr Asn 
    1085                 1090                 1095             


Glu Ala  Pro Ser Val Pro Ala  Asp Tyr Ala Ser Val  Tyr Glu Glu 
    1100                 1105                 1110             


Lys Ser  Tyr Thr Asp Gly Arg  Arg Glu Asn Pro Cys  Glu Phe Asn 
    1115                 1120                 1125             


Arg Gly  Tyr Arg Asp Tyr Thr  Pro Leu Pro Val Gly  Tyr Val Thr 
    1130                 1135                 1140             


Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp Lys Val  Trp Ile Glu 
    1145                 1150                 1155             


Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val Asp Ser  Val Glu Leu 
    1160                 1165                 1170             


Leu Leu  Met Glu Glu 
    1175             


<210>  5
<211>  798
<212>  PRT
<213>  Bacillus thuringiensis

<400>  5

Met Gln Arg Met Ile Ile Val Asp Asn Asn Lys Leu Asn Val Arg Ala 
1               5                   10                  15      


Leu Pro Ser Phe Ile Asp Tyr Phe Asn Gly Ile Tyr Gly Phe Ala Thr 
            20                  25                  30          


Gly Ile Lys Asp Ile Met Gly Met Ile Phe Lys Thr Asp Thr Gly Gly 
        35                  40                  45              


Ser Asn Leu Thr Leu Asp Glu Ile Leu Lys Asn Gln Asn Leu Leu Asn 
    50                  55                  60                  


Asp Ile Ser Gly Lys Leu Asp Gly Ile Asn Gly Asp Leu Gly Asp Leu 
65                  70                  75                  80  


Ile Ala Gln Gly Asn Leu Asn Ser Glu Leu Ala Lys Glu Leu Leu Lys 
                85                  90                  95      


Ile Ser Asn Glu Gln Asn Gln Met Leu Asn His Val Asn Ala Gln Leu 
            100                 105                 110         


Asn Ala Ile Asn Ser Thr Leu Asn Ile Tyr Leu Pro Lys Ile Thr Ser 
        115                 120                 125             


Met Leu Asn Glu Val Met Lys Gln Asn His Val Leu Ser Leu Gln Ile 
    130                 135                 140                 


Glu Phe Leu Ser Lys Gln Leu Gln Glu Ile Ser Asp Lys Leu Asp Ile 
145                 150                 155                 160 


Ile Asn Leu Asn Val Leu Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro 
                165                 170                 175     


Ala Tyr Gln Arg Ile Lys Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr 
            180                 185                 190         


Ser Thr Val Glu Lys Asn Pro Lys Ser Tyr Gln Asp Asn Val Thr Lys 
        195                 200                 205             


Glu Val Ile Glu Asn Leu Asn Glu Leu Thr Glu Leu Ala Lys Ser Val 
    210                 215                 220                 


Thr Lys Asn Asp Met Asp Ser Phe Glu Phe Tyr Leu Gln Thr Phe His 
225                 230                 235                 240 


Asp Val Met Thr Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr 
                245                 250                 255     


Ala Ser Glu Leu Ile Thr Lys Glu Asn Val Thr Thr Arg Gly Ser Glu 
            260                 265                 270         


Ile Gly Lys Val Tyr Asn Phe Leu Ile Val Leu Thr Ser Leu Gln Ala 
        275                 280                 285             


Lys Ala Phe Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Thr 
    290                 295                 300                 


Asp Ile Asp Tyr Thr Gln Ile Met Asn His His Ile Asp Gly Gln Lys 
305                 310                 315                 320 


Arg Glu Phe Arg Ile Asn Ile Leu Pro Thr Leu Ser Asn Asn Phe Ser 
                325                 330                 335     


Asn Pro Ser Tyr Ser Lys Asn Arg Gly Ser Asp Ile Asp Asp Pro Ile 
            340                 345                 350         


Val Val Leu Glu Ala Ala Pro Gly Tyr Ala Leu Ile Gly Phe Glu Ile 
        355                 360                 365             


Leu Asn Asp Pro Leu Pro Ile Leu Lys Gly Tyr Gln Ala Arg Leu Lys 
    370                 375                 380                 


Pro Asn Tyr Gln Val Asp Arg Glu Ser Met Ser Glu Thr Ile Tyr Gly 
385                 390                 395                 400 


Asp Ile His Lys Leu Phe Cys Pro Lys Gln Leu Glu Gln Lys Tyr Tyr 
                405                 410                 415     


Ile Lys Asp Ile Glu Phe Pro Glu Gly Tyr Val Ile Thr Lys Ile Val 
            420                 425                 430         


Phe Glu Lys Arg Leu Asn Gln Leu Gly Tyr Glu Val Thr Ala Asn Phe 
        435                 440                 445             


Tyr Asp Pro Ser Thr Gly Ser Ile Asp Leu Asn Lys Val Lys Val Glu 
    450                 455                 460                 


Ser Trp Lys Glu Lys Ser Cys Glu Glu Asp Ser Cys Glu Asp Glu Tyr 
465                 470                 475                 480 


Ser Ile Ile Lys Ala Glu Thr Asp Gly Ile Tyr Met Pro Leu Gly Val 
                485                 490                 495     


Val Ser Glu Thr Phe Leu Thr Pro Ile Tyr Gly Phe Gly Leu Thr Val 
            500                 505                 510         


Asp Glu Lys Asn Gln Lys Ile Thr Leu Thr Gly Lys Ser Tyr Leu Arg 
        515                 520                 525             


Glu Ser Leu Leu Glu Thr Asp Leu Leu Asn Asn Glu Thr Tyr Leu Ile 
    530                 535                 540                 


Ala Ser Pro Asp Gly Tyr Ile Ser Ser Ile Val Glu Asn Trp Asn Ile 
545                 550                 555                 560 


Thr Ser Asp Asn Thr Gly Ser Trp Arg Ala Asn Asn Asn Asn Ala Phe 
                565                 570                 575     


Val Asp Lys Ala Asp Thr Ile Lys Gly Ser Ser Ser Leu Tyr Thr His 
            580                 585                 590         


Lys Asp Gly Glu Phe Ser Gln Phe Ile Gly Asn Lys Leu Lys Pro Lys 
        595                 600                 605             


Thr Asn Tyr Val Ile Gln Tyr Val Ile Lys Gly Arg Pro Ala Ile Tyr 
    610                 615                 620                 


Leu Lys Asn Asn Lys Asp Thr Leu Phe Glu Asp Thr Lys Asn Asn Phe 
625                 630                 635                 640 


Ser Asp Phe Gln Thr Val Thr Lys Lys Phe Asn Ser Gly Val Asn Pro 
                645                 650                 655     


Ser Glu Ile Tyr Phe Leu Phe Lys Asn Gln Ser Glu Tyr Glu Ala Trp 
            660                 665                 670         


Gly Asn Asn Phe Ile Ile Leu Glu Ile Lys Ser Leu Glu Phe Leu Pro 
        675                 680                 685             


Gln Met Leu Lys Pro Glu Asp Trp Ile Pro Ser Gly Asn Val Gln Met 
    690                 695                 700                 


Lys Asp Gly Gly Arg Leu Glu Ile Leu Gly Asp Gly Tyr Phe Lys Gln 
705                 710                 715                 720 


Phe Ile Lys Leu Glu Asn Asp Ser Thr Tyr His Leu Arg Leu Ser Val 
                725                 730                 735     


Lys Gly Thr Gly Arg Val Ser Ile Ile Asp Glu Ser Lys Tyr Leu Leu 
            740                 745                 750         


Phe Val Asn Val Lys Asp Glu Asp Leu Thr Arg Val Ile Lys Asn Thr 
        755                 760                 765             


Ser Ser Lys Gly Glu Cys Phe Ile Ala Leu Glu Gly Thr Tyr Val Glu 
    770                 775                 780                 


Asn Ser Ser Thr Ile Phe Ser Asn Val Ser Ile Val Lys Glu 
785                 790                 795             


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  6

Val Asp Trp Trp Ser Pro Phe Tyr Asp Arg Leu Lys 
1               5                   10          


<210>  7
<211>  807
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  7

Met Gln Arg Met Ile Ile Val Asp Asn Asn Lys Leu Asn Val Arg Ala 
1               5                   10                  15      


Leu Pro Ser Phe Ile Asp Tyr Phe Asn Gly Ile Tyr Gly Phe Ala Thr 
            20                  25                  30          


Gly Ile Lys Asp Ile Met Gly Met Ile Phe Lys Thr Asp Thr Gly Gly 
        35                  40                  45              


Ser Asn Leu Thr Leu Asp Glu Ile Leu Lys Asn Gln Asn Leu Leu Asn 
    50                  55                  60                  


Asp Ile Ser Gly Lys Leu Asp Gly Ile Asn Gly Asp Leu Gly Asp Leu 
65                  70                  75                  80  


Ile Ala Gln Gly Asn Leu Asn Ser Glu Leu Ala Lys Glu Leu Leu Lys 
                85                  90                  95      


Ile Ser Asn Glu Gln Asn Gln Met Leu Asn His Val Asn Ala Gln Leu 
            100                 105                 110         


Asn Ala Ile Asn Ser Thr Leu Asn Ile Tyr Leu Pro Lys Ile Thr Ser 
        115                 120                 125             


Met Leu Asn Glu Val Met Lys Gln Asn His Val Leu Ser Leu Gln Ile 
    130                 135                 140                 


Glu Phe Leu Ser Lys Gln Leu Gln Glu Ile Ser Asp Lys Leu Asp Ile 
145                 150                 155                 160 


Ile Asn Leu Asn Val Leu Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro 
                165                 170                 175     


Ala Tyr Gln Arg Ile Lys Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr 
            180                 185                 190         


Ser Thr Val Glu Lys Asn Pro Lys Ser Tyr Gln Asp Asn Val Thr Lys 
        195                 200                 205             


Glu Val Ile Glu Asn Leu Asn Glu Leu Thr Glu Leu Ala Lys Ser Val 
    210                 215                 220                 


Thr Lys Asn Asp Met Asp Ser Phe Glu Phe Tyr Leu Gln Thr Phe His 
225                 230                 235                 240 


Asp Val Met Thr Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr 
                245                 250                 255     


Ala Ser Glu Leu Ile Thr Lys Glu Asn Val Thr Thr Arg Gly Ser Glu 
            260                 265                 270         


Ile Gly Lys Val Tyr Asn Phe Leu Ile Val Leu Thr Ser Leu Gln Ala 
        275                 280                 285             


Lys Ala Phe Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Thr 
    290                 295                 300                 


Asp Ile Asp Tyr Thr Gln Ile Met Asn His His Ile Asp Gly Gln Lys 
305                 310                 315                 320 


Arg Glu Phe Arg Ile Asn Ile Leu Pro Thr Leu Ser Asn Asn Phe Ser 
                325                 330                 335     


Asn Pro Ser Tyr Ser Lys Asn Arg Gly Ser Asp Ile Asp Asp Pro Ile 
            340                 345                 350         


Val Val Leu Glu Ala Ala Pro Gly Tyr Ala Leu Ile Gly Phe Glu Ile 
        355                 360                 365             


Leu Asn Asp Pro Leu Pro Ile Leu Lys Gly Tyr Gln Ala Arg Leu Lys 
    370                 375                 380                 


Pro Asn Tyr Gln Val Asp Arg Glu Ser Met Ser Glu Thr Ile Tyr Gly 
385                 390                 395                 400 


Asp Ile His Lys Leu Phe Cys Pro Lys Gln Leu Glu Gln Lys Tyr Tyr 
                405                 410                 415     


Ile Lys Asp Ile Glu Phe Pro Glu Gly Tyr Val Ile Thr Lys Ile Val 
            420                 425                 430         


Phe Glu Lys Arg Leu Asn Gln Leu Gly Tyr Glu Val Thr Ala Asn Phe 
        435                 440                 445             


Tyr Asp Pro Ser Thr Gly Ser Ile Asp Leu Asn Lys Val Lys Val Glu 
    450                 455                 460                 


Ser Trp Lys Glu Lys Ser Cys Glu Glu Asp Ser Cys Glu Asp Glu Tyr 
465                 470                 475                 480 


Ser Ile Ile Lys Ala Glu Thr Asp Gly Ile Tyr Met Pro Leu Gly Val 
                485                 490                 495     


Val Ser Glu Thr Phe Leu Thr Pro Ile Tyr Gly Phe Gly Leu Thr Val 
            500                 505                 510         


Asp Glu Lys Asn Gln Lys Ile Thr Leu Thr Gly Lys Ser Tyr Leu Arg 
        515                 520                 525             


Glu Ser Leu Leu Glu Thr Asp Leu Leu Asn Asn Glu Thr Tyr Leu Ile 
    530                 535                 540                 


Ala Ser Pro Asp Gly Tyr Ile Ser Ser Ile Val Glu Asn Trp Asn Ile 
545                 550                 555                 560 


Thr Ser Asp Asn Thr Gly Ser Trp Arg Ala Asn Asn Asn Asn Ala Phe 
                565                 570                 575     


Val Asp Lys Ala Asp Thr Ile Lys Gly Ser Ser Ser Leu Tyr Thr His 
            580                 585                 590         


Lys Asp Gly Glu Phe Ser Gln Phe Ile Gly Asn Lys Leu Lys Pro Lys 
        595                 600                 605             


Thr Asn Tyr Val Ile Gln Tyr Val Ile Lys Gly Arg Pro Ala Ile Tyr 
    610                 615                 620                 


Leu Lys Asn Asn Lys Asp Thr Leu Phe Glu Asp Thr Lys Asn Asn Phe 
625                 630                 635                 640 


Ser Asp Phe Gln Thr Val Thr Lys Lys Phe Asn Ser Gly Val Asn Pro 
                645                 650                 655     


Ser Glu Ile Tyr Phe Leu Phe Lys Asn Gln Ser Glu Tyr Glu Ala Trp 
            660                 665                 670         


Gly Asn Asn Phe Ile Ile Leu Glu Ile Lys Ser Leu Glu Phe Leu Pro 
        675                 680                 685             


Gln Met Leu Lys Pro Glu Asp Trp Ile Pro Ser Gly Asn Val Gln Met 
    690                 695                 700                 


Lys Asp Gly Gly Arg Leu Glu Ile Leu Gly Asp Gly Tyr Phe Lys Gln 
705                 710                 715                 720 


Phe Ile Lys Leu Glu Asn Asp Ser Thr Tyr His Leu Arg Leu Ser Val 
                725                 730                 735     


Lys Gly Thr Gly Arg Val Ser Ile Ile Asp Val Asp Trp Trp Ser Pro 
            740                 745                 750         


Phe Tyr Asp Arg Leu Lys Tyr Leu Leu Phe Val Asn Val Lys Asp Glu 
        755                 760                 765             


Asp Leu Thr Arg Val Ile Lys Asn Thr Ser Ser Lys Gly Glu Cys Phe 
    770                 775                 780                 


Ile Ala Leu Glu Gly Thr Tyr Val Glu Asn Ser Ser Thr Ile Phe Ser 
785                 790                 795                 800 


Asn Val Ser Ile Val Lys Glu 
                805         


<210>  8
<211>  1177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  8

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp His Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Ile Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ser Arg Thr Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Gly Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Glu Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Ala Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Glu Phe Asn Asn 
    450                 455                 460                 


Ile Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Leu Val Lys Ala His 
465                 470                 475                 480 


Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro Gly Phe Thr Gly 
                485                 490                 495     


Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe Ala Tyr Thr Ile 
            500                 505                 510         


Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg Ala Arg Ile Arg 
        515                 520                 525             


Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr Val Ala Gly Glu 
    530                 535                 540                 


Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp Thr Gly Asp Pro 
545                 550                 555                 560 


Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn Thr Ala Phe Thr 
                565                 570                 575     


Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala Asp Thr Phe Ser 
            580                 585                 590         


Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu Ile Pro Val Thr 
        595                 600                 605             


Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala Val 
    610                 615                 620                 


Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val 
625                 630                 635                 640 


Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu Ser 
                645                 650                 655     


Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys 
            660                 665                 670         


His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn 
        675                 680                 685             


Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr 
    690                 695                 700                 


Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val 
705                 710                 715                 720 


Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln 
                725                 730                 735     


Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg 
            740                 745                 750         


Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Ser Ile Arg Tyr 
        755                 760                 765             


Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp 
    770                 775                 780                 


Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg 
785                 790                 795                 800 


Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg 
                805                 810                 815     


Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile 
            820                 825                 830         


Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile 
        835                 840                 845             


Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu 
    850                 855                 860                 


Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys 
865                 870                 875                 880 


Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu 
                885                 890                 895     


Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe 
            900                 905                 910         


Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala Met 
        915                 920                 925             


Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu 
    930                 935                 940                 


Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu 
945                 950                 955                 960 


Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn 
                965                 970                 975     


Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn Val 
            980                 985                 990         


Lys Gly His Val Asp Val Glu Glu  Gln Asn Asn Gln Arg  Ser Val Leu 
        995                 1000                 1005             


Val Val  Pro Glu Trp Glu Ala  Glu Val Ser Gln Glu  Val Arg Val 
    1010                 1015                 1020             


Cys Pro  Gly Arg Gly Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu 
    1025                 1030                 1035             


Gly Tyr  Gly Glu Gly Cys Val  Thr Ile His Glu Ile  Glu Asn Asn 
    1040                 1045                 1050             


Thr Asp  Glu Leu Lys Phe Ser  Asn Cys Val Glu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Thr Val Thr Cys  Asn Asp Tyr Thr Val  Asn Gln Glu 
    1070                 1075                 1080             


Glu Tyr  Gly Gly Ala Tyr Thr  Ser Arg Asn Arg Gly  Tyr Asn Glu 
    1085                 1090                 1095             


Ala Pro  Ser Val Pro Ala Asp  Tyr Ala Ser Val Tyr  Glu Glu Lys 
    1100                 1105                 1110             


Ser Tyr  Thr Asp Gly Arg Arg  Glu Asn Pro Cys Glu  Phe Asn Arg 
    1115                 1120                 1125             


Gly Tyr  Arg Asp Tyr Thr Pro  Leu Pro Val Gly Tyr  Val Thr Lys 
    1130                 1135                 1140             


Glu Leu  Glu Tyr Phe Pro Glu  Thr Asp Lys Val Trp  Ile Glu Ile 
    1145                 1150                 1155             


Gly Glu  Thr Glu Gly Thr Phe  Ile Val Asp Ser Val  Glu Leu Leu 
    1160                 1165                 1170             


Leu Met  Glu Glu 
    1175         


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  9

Ser Asp Tyr Gly Trp Trp Arg Pro Phe Gln Pro Gly 
1               5                   10          


<210>  10
<211>  1186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  10

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp His Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Ile Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ser Arg Thr Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Gly Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Glu Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Ser Asp Tyr Gly Trp Trp Arg Pro Phe Gln Pro 
            340                 345                 350         


Gly Ala Pro Gln Gln Arg Ile Val Ala Gln Leu Gly Gln Gly Val Tyr 
        355                 360                 365             


Arg Thr Leu Ser Ser Thr Leu Tyr Arg Arg Pro Phe Asn Ile Gly Ile 
    370                 375                 380                 


Asn Asn Gln Gln Leu Ser Val Leu Asp Gly Thr Glu Phe Ala Tyr Gly 
385                 390                 395                 400 


Thr Ser Ser Asn Leu Pro Ser Ala Val Tyr Arg Lys Ser Gly Thr Val 
                405                 410                 415     


Asp Ser Leu Asp Glu Ile Pro Pro Gln Asn Asn Asn Val Pro Pro Arg 
            420                 425                 430         


Gln Gly Phe Ser His Arg Leu Ser His Val Ser Met Phe Arg Ser Gly 
        435                 440                 445             


Phe Ser Asn Ser Ser Val Ser Ile Ile Arg Ala Pro Met Phe Ser Trp 
    450                 455                 460                 


Ile His Arg Ser Ala Glu Phe Asn Asn Ile Ile Ala Ser Asp Ser Ile 
465                 470                 475                 480 


Thr Gln Ile Pro Leu Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr 
                485                 490                 495     


Val Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr 
            500                 505                 510         


Ser Gly Gly Pro Phe Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu 
        515                 520                 525             


Pro Gln Arg Tyr Arg Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu 
    530                 535                 540                 


Arg Ile Tyr Val Thr Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe 
545                 550                 555                 560 


Asn Lys Thr Met Asp Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser 
                565                 570                 575     


Tyr Ala Thr Ile Asn Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser 
            580                 585                 590         


Phe Thr Val Gly Ala Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile 
        595                 600                 605             


Asp Arg Phe Glu Leu Ile Pro Val Thr Ala Thr Leu Glu Ala Glu Tyr 
    610                 615                 620                 


Asn Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr 
625                 630                 635                 640 


Asn Gln Leu Gly Leu Lys Thr Asn Val Thr Asp Tyr His Ile Asp Gln 
                645                 650                 655     


Val Ser Asn Leu Val Thr Tyr Leu Ser Asp Glu Phe Cys Leu Asp Glu 
            660                 665                 670         


Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp 
        675                 680                 685             


Glu Arg Asn Leu Leu Gln Asp Ser Asn Phe Lys Asp Ile Asn Arg Gln 
    690                 695                 700                 


Pro Glu Arg Gly Trp Gly Gly Ser Thr Gly Ile Thr Ile Gln Gly Gly 
705                 710                 715                 720 


Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Ser Gly Thr Phe Asp 
                725                 730                 735     


Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu 
            740                 745                 750         


Lys Ala Phe Thr Arg Tyr Gln Leu Arg Gly Tyr Ile Glu Asp Ser Gln 
        755                 760                 765             


Asp Leu Glu Ile Tyr Ser Ile Arg Tyr Asn Ala Lys His Glu Thr Val 
    770                 775                 780                 


Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro 
785                 790                 795                 800 


Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu Glu Trp 
                805                 810                 815     


Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His 
            820                 825                 830         


His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu 
        835                 840                 845             


Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp 
    850                 855                 860                 


Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu 
865                 870                 875                 880 


Val Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg 
                885                 890                 895     


Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile Val Tyr Lys Glu 
            900                 905                 910         


Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Gln 
        915                 920                 925             


Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg 
    930                 935                 940                 


Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro 
945                 950                 955                 960 


Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr 
                965                 970                 975     


Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe 
            980                 985                 990         


Asn Asn Gly Leu Ser Cys Trp Asn  Val Lys Gly His Val  Asp Val Glu 
        995                 1000                 1005             


Glu Gln  Asn Asn Gln Arg Ser  Val Leu Val Val Pro  Glu Trp Glu 
    1010                 1015                 1020             


Ala Glu  Val Ser Gln Glu Val  Arg Val Cys Pro Gly  Arg Gly Tyr 
    1025                 1030                 1035             


Ile Leu  Arg Val Thr Ala Tyr  Lys Glu Gly Tyr Gly  Glu Gly Cys 
    1040                 1045                 1050             


Val Thr  Ile His Glu Ile Glu  Asn Asn Thr Asp Glu  Leu Lys Phe 
    1055                 1060                 1065             


Ser Asn  Cys Val Glu Glu Glu  Ile Tyr Pro Asn Asn  Thr Val Thr 
    1070                 1075                 1080             


Cys Asn  Asp Tyr Thr Val Asn  Gln Glu Glu Tyr Gly  Gly Ala Tyr 
    1085                 1090                 1095             


Thr Ser  Arg Asn Arg Gly Tyr  Asn Glu Ala Pro Ser  Val Pro Ala 
    1100                 1105                 1110             


Asp Tyr  Ala Ser Val Tyr Glu  Glu Lys Ser Tyr Thr  Asp Gly Arg 
    1115                 1120                 1125             


Arg Glu  Asn Pro Cys Glu Phe  Asn Arg Gly Tyr Arg  Asp Tyr Thr 
    1130                 1135                 1140             


Pro Leu  Pro Val Gly Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro 
    1145                 1150                 1155             


Glu Thr  Asp Lys Val Trp Ile  Glu Ile Gly Glu Thr  Glu Gly Thr 
    1160                 1165                 1170             


Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu Met Glu  Glu 
    1175                 1180                 1185     


<210>  11
<211>  1190
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  11

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Arg Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Tyr Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Val Asp Trp Trp Ser Pro Phe Tyr Asp 
            340                 345                 350         


Arg Leu Lys Ala Ala Pro Gln Gln Arg Ile Val Ala Gln Leu Gly Gln 
        355                 360                 365             


Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg Arg Pro Phe Asn 
    370                 375                 380                 


Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp Gly Thr Glu Phe 
385                 390                 395                 400 


Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val Tyr Arg Lys Ser 
                405                 410                 415     


Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln Asn Asn Asn Val 
            420                 425                 430         


Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His Val Ser Met Phe 
        435                 440                 445             


Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile Arg Ala Pro Met 
    450                 455                 460                 


Phe Ser Trp Ile His Arg Ser Ala Glu Phe Asn Asn Ile Ile Ala Ser 
465                 470                 475                 480 


Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn Phe Leu Phe Asn 
                485                 490                 495     


Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly Asp Leu Val Arg 
            500                 505                 510         


Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly Tyr Ile Glu Val 
        515                 520                 525             


Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg Val Arg Val Arg 
    530                 535                 540                 


Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn Trp Gly Asn Ser 
545                 550                 555                 560 


Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr Ser Leu Asp Asn 
                565                 570                 575     


Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala Asn Ala Phe Thr 
            580                 585                 590         


Ser Ser Leu Gly Asn Ile Val Gly Val Arg Asn Phe Ser Gly Thr Ala 
        595                 600                 605             


Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val Thr Ala Thr Leu 
    610                 615                 620                 


Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu 
625                 630                 635                 640 


Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val Thr Asp Tyr 
                645                 650                 655     


His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu Ser Asp Glu Phe 
            660                 665                 670         


Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys 
        675                 680                 685             


Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn Phe Lys Asp 
    690                 695                 700                 


Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr Gly Ile Thr 
705                 710                 715                 720 


Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Ser 
                725                 730                 735     


Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp 
            740                 745                 750         


Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg Gly Tyr Ile 
        755                 760                 765             


Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys 
    770                 775                 780                 


His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser 
785                 790                 795                 800 


Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro 
                805                 810                 815     


His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp Gly Glu 
            820                 825                 830         


Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile Asp Val Gly 
        835                 840                 845             


Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile 
    850                 855                 860                 


Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu 
865                 870                 875                 880 


Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu 
                885                 890                 895     


Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile 
            900                 905                 910         


Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser 
        915                 920                 925             


Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala 
    930                 935                 940                 


Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu 
945                 950                 955                 960 


Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly 
                965                 970                 975     


Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys 
            980                 985                 990         


Asn Gly Asp Phe Asn Asn Gly Leu  Ser Cys Trp Asn Val  Lys Gly His 
        995                 1000                 1005             


Val Asp  Val Glu Glu Gln Asn  Asn Gln Arg Ser Val  Leu Val Val 
    1010                 1015                 1020             


Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu Val Arg  Val Cys Pro 
    1025                 1030                 1035             


Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala Tyr Lys  Glu Gly Tyr 
    1040                 1045                 1050             


Gly Glu  Gly Cys Val Thr Ile  His Glu Ile Glu Asn  Asn Thr Asp 
    1055                 1060                 1065             


Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu Glu Ile  Tyr Pro Asn 
    1070                 1075                 1080             


Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Val Asn Gln  Glu Glu Tyr 
    1085                 1090                 1095             


Gly Gly  Ala Tyr Thr Ser Arg  Asn Arg Gly Tyr Asn  Glu Ala Pro 
    1100                 1105                 1110             


Ser Val  Pro Ala Asp Tyr Ala  Ser Val Tyr Glu Glu  Lys Ser Tyr 
    1115                 1120                 1125             


Thr Asp  Gly Arg Arg Glu Asn  Pro Cys Glu Phe Asn  Arg Gly Tyr 
    1130                 1135                 1140             


Arg Asp  Tyr Thr Pro Leu Pro  Val Gly Tyr Val Thr  Lys Glu Leu 
    1145                 1150                 1155             


Glu Tyr  Phe Pro Glu Thr Asp  Lys Val Trp Ile Glu  Ile Gly Glu 
    1160                 1165                 1170             


Thr Glu  Gly Thr Phe Ile Val  Asp Ser Val Glu Leu  Leu Leu Met 
    1175                 1180                 1185             


Glu Glu  
    1190 


<210>  12
<211>  1177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  12

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp His Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Ile Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ser Arg Thr Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Gly Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Glu Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Tyr Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Ala Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ile Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Gly Phe Cys Asn 
    450                 455                 460                 


Ile Ile Arg Gly Asp Ser Ile Thr Gln Ile Pro Leu Val Lys Ala Tyr 
465                 470                 475                 480 


Ala Leu His Ser Gly Thr Thr Val Val Arg Gly Pro Gly Phe Thr Gly 
                485                 490                 495     


Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe Ala Cys Thr Ile 
            500                 505                 510         


Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Cys Ala Arg Ile Arg 
        515                 520                 525             


Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr Val Ala Gly Glu 
    530                 535                 540                 


Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn Thr Gly Asp Pro 
545                 550                 555                 560 


Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn Thr Ala Phe Thr 
                565                 570                 575     


Phe Pro Met Arg Gln Ser Ser Phe Thr Val Gly Ala Asp Thr Phe Ser 
            580                 585                 590         


Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu Ile Pro Val Ala 
        595                 600                 605             


Ala Thr Leu Gln Ala Glu Tyr Asp Leu Glu Arg Ala Gln Lys Ala Val 
    610                 615                 620                 


Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val 
625                 630                 635                 640 


Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Tyr Leu Ser 
                645                 650                 655     


Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys 
            660                 665                 670         


His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn 
        675                 680                 685             


Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr 
    690                 695                 700                 


Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val 
705                 710                 715                 720 


Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln 
                725                 730                 735     


Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg 
            740                 745                 750         


Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Ser Ile Arg Tyr 
        755                 760                 765             


Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp 
    770                 775                 780                 


Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg 
785                 790                 795                 800 


Cys Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg 
                805                 810                 815     


Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile 
            820                 825                 830         


Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile 
        835                 840                 845             


Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu 
    850                 855                 860                 


Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys 
865                 870                 875                 880 


Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu 
                885                 890                 895     


Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe 
            900                 905                 910         


Val Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala Met 
        915                 920                 925             


Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu 
    930                 935                 940                 


Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu 
945                 950                 955                 960 


Leu Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn 
                965                 970                 975     


Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn Val 
            980                 985                 990         


Lys Gly His Val Asp Val Glu Glu  Gln Asn Asn Gln Arg  Ser Val Leu 
        995                 1000                 1005             


Val Val  Pro Glu Trp Glu Ala  Glu Val Ser Gln Glu  Val Arg Val 
    1010                 1015                 1020             


Cys Pro  Gly Arg Gly Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu 
    1025                 1030                 1035             


Gly Tyr  Gly Glu Gly Cys Val  Thr Ile His Glu Ile  Glu Asn Asn 
    1040                 1045                 1050             


Thr Asp  Glu Leu Lys Phe Ser  Asn Cys Val Glu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Thr Val Thr Cys  Asn Asp Tyr Thr Val  Asn Gln Glu 
    1070                 1075                 1080             


Glu Tyr  Gly Gly Ala Tyr Thr  Ser Arg Asn Arg Gly  Tyr Asn Glu 
    1085                 1090                 1095             


Ala Pro  Ser Val Pro Ala Asp  Tyr Ala Ser Val Tyr  Glu Glu Lys 
    1100                 1105                 1110             


Ser Tyr  Thr Asp Gly Arg Arg  Glu Asn Pro Cys Glu  Phe Asn Arg 
    1115                 1120                 1125             


Gly Tyr  Arg Asp Tyr Thr Pro  Leu Pro Val Gly Tyr  Val Thr Lys 
    1130                 1135                 1140             


Glu Leu  Glu Tyr Phe Pro Glu  Thr Asp Lys Val Trp  Ile Glu Ile 
    1145                 1150                 1155             


Gly Glu  Thr Glu Gly Thr Phe  Ile Val Asp Ser Val  Glu Leu Leu 
    1160                 1165                 1170             


Leu Met  Glu Glu 
    1175         


<210>  13
<211>  1743
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  13

Met Glu Val Asp Val Arg Ile Thr Thr Ala Ala Leu Leu Ile Phe Ala 
1               5                   10                  15      


Ala Thr Leu Val Ser Ala Gln Thr Asn Gln Leu Arg Cys Thr Tyr Ile 
            20                  25                  30          


Gln Glu Ile Pro Arg Gly Asp Thr Pro Val Phe Asn Phe Pro Ser Phe 
        35                  40                  45              


Asp Gly Val Pro Trp Ser Gln Gln Pro Leu Leu Pro Leu Pro Gln Arg 
    50                  55                  60                  


Glu Glu Leu Cys Met Glu Asp Pro Val Ser Ala Gly Ser Ser Val Ile 
65                  70                  75                  80  


Met Thr Ile Tyr Met Glu Glu Glu Ile Glu Glu Glu Ile Ala Ile Ala 
                85                  90                  95      


Lys Leu Asn Tyr Lys Gly Thr Gly Thr Pro Glu Ile Gly Pro Ala Phe 
            100                 105                 110         


Thr Thr Gly Ser Phe His Thr Leu Gly Pro Val Phe Arg Arg Ile Pro 
        115                 120                 125             


Glu Asp Gly Glu Trp His Leu Val Ile Thr Asn Lys Gln Asp Phe Glu 
    130                 135                 140                 


Ala Pro Asn Met Gln Arg Tyr Trp Phe Asp Ile Ser Val Pro Gly Glu 
145                 150                 155                 160 


Ser Val Gly Leu Met Val Leu Leu Glu Ile Val Asn Ile Asp Asp Asn 
                165                 170                 175     


Ala Pro Ile Val His Met Ile Asp Arg Cys Glu Ile Pro Glu Pro Gly 
            180                 185                 190         


Thr His Gly Arg Thr Ala Cys Ala Tyr Thr Val Ser Asp Ala Asp Gly 
        195                 200                 205             


Arg Ile Ser Thr Glu Phe Met Thr Tyr Lys Ile Asp Ser Asp Arg Asn 
    210                 215                 220                 


Asp Gln Asp Phe Phe Glu Leu Val Asn Asp His Thr Met Asp Ala Asp 
225                 230                 235                 240 


Glu Lys Ile Thr His Met Val Leu Tyr Leu His Lys Asp Leu Asp Phe 
                245                 250                 255     


Glu Val Asn Pro Leu His Ile Phe Ser Val Thr Ala Phe Asp Ser Lys 
            260                 265                 270         


Pro Asn Glu His Glu Val Thr Met Met Val Gln Val Gln Asn Thr Asp 
        275                 280                 285             


Arg Arg Asn Pro Arg Trp Leu Asp Ile Phe Ala Val Gln Gln Phe Asn 
    290                 295                 300                 


Glu Lys Gln Ala Lys Ser Phe Thr Val Arg Ala Ile Asp Gly Asp Thr 
305                 310                 315                 320 


Gly Ile Asn Lys Pro Ile Phe Tyr Arg Ile Glu Thr Glu Asp Glu Asp 
                325                 330                 335     


Lys Glu Phe Phe Ser Ile Glu Asn Met Gly Glu Gly Arg Asp Gly Ala 
            340                 345                 350         


Arg Phe His Val Ala Pro Ile Asp Arg Asp Tyr Leu Lys Arg Asp Met 
        355                 360                 365             


Phe His Ile Arg Ile Ile Ala Tyr Lys Gln Gly Asp Asn Asp Lys Glu 
    370                 375                 380                 


Gly Glu Ser Ser Phe Glu Thr Ser Ala Asn Val Thr Ile Ile Ile Asn 
385                 390                 395                 400 


Asp Ile Asn Asp Gln Arg Pro Glu Pro Phe His Lys Glu Tyr Thr Ile 
                405                 410                 415     


Ser Ile Met Glu Glu Thr Ala Met Thr Leu Asp Leu Gln Glu Phe Gly 
            420                 425                 430         


Phe His Asp Arg Asp Ile Gly Pro His Ala Gln Tyr Asp Val His Leu 
        435                 440                 445             


Glu Ser Ile Gln Pro Asp Gly Ala His Thr Ala Phe Tyr Ile Ala Pro 
    450                 455                 460                 


Glu Glu Gly Tyr Gln Ala Gln Ser Phe Thr Ile Gly Thr Arg Ile His 
465                 470                 475                 480 


Asn Met Leu Asp Tyr Glu Asp Asp Asp Tyr Arg Pro Gly Ile Lys Leu 
                485                 490                 495     


Lys Ala Val Ala Ile Asp Arg His Asp Asn Asn His Ile Gly Glu Ala 
            500                 505                 510         


Ile Ile Asn Ile Asn Leu Ile Asn Trp Asn Asp Glu Leu Pro Ile Phe 
        515                 520                 525             


Asp Glu Asp Ala Tyr Asn Val Thr Phe Glu Glu Thr Val Gly Asp Gly 
    530                 535                 540                 


Phe His Val Gly Lys Tyr Arg Ala Lys Asp Arg Asp Ile Gly Asp Ile 
545                 550                 555                 560 


Val Glu His Ser Ile Leu Gly Asn Ala Ala Asn Phe Leu Arg Ile Asp 
                565                 570                 575     


Ile Glu Thr Gly Asp Val Tyr Val Ser Arg Asp Asp Tyr Phe Asp Tyr 
            580                 585                 590         


Gln Arg Gln Asn Glu Ile Ile Val Gln Ile Leu Ala Val Asp Thr Leu 
        595                 600                 605             


Gly Leu Pro Gln Asn Arg Ala Thr Thr Gln Leu Thr Ile Phe Leu Glu 
    610                 615                 620                 


Asp Ile Asn Asn Thr Pro Pro Ile Leu Arg Leu Pro Arg Ser Ser Pro 
625                 630                 635                 640 


Ser Val Glu Glu Asn Val Glu Val Gly His Pro Ile Thr Glu Gly Leu 
                645                 650                 655     


Thr Ala Thr Asp Pro Asp Thr Thr Ala Asp Leu His Phe Glu Ile Asp 
            660                 665                 670         


Trp Asp Asn Ser Tyr Ala Thr Lys Gln Gly Thr Asn Gly Pro Asn Thr 
        675                 680                 685             


Ala Asp Tyr His Gly Cys Val Glu Ile Leu Thr Val Tyr Pro Asp Pro 
    690                 695                 700                 


His Asn Arg Gly Arg Ala Glu Gly His Leu Val Ala Arg Glu Val Ser 
705                 710                 715                 720 


Asp Gly Val Thr Ile Asp Tyr Glu Lys Phe Glu Val Leu Tyr Leu Val 
                725                 730                 735     


Val Arg Val Ile Asp Arg Asn Thr Val Ile Gly Pro Asp Tyr Asp Glu 
            740                 745                 750         


Ala Met Leu Thr Val Thr Ile Ile Asp Met Asn Asp Asn Trp Pro Ile 
        755                 760                 765             


Trp Ala Asp Asn Thr Leu Gln Gln Thr Leu Arg Val Arg Glu Met Ala 
    770                 775                 780                 


Asp Glu Gly Val Ile Val Gly Thr Leu Leu Ala Thr Asp Leu Asp Gly 
785                 790                 795                 800 


Pro Leu Tyr Asn Arg Val Arg Tyr Thr Met Val Pro Ile Lys Asp Thr 
                805                 810                 815     


Pro Asp Asp Leu Ile Ala Ile Asn Tyr Val Thr Gly Gln Leu Thr Val 
            820                 825                 830         


Asn Lys Gly Gln Ala Ile Asp Ala Asp Asp Pro Pro Arg Phe Tyr Leu 
        835                 840                 845             


Tyr Tyr Lys Val Thr Ala Ser Asp Lys Cys Ser Leu Asp Glu Phe Phe 
    850                 855                 860                 


Pro Val Cys Pro Pro Asp Pro Thr Tyr Trp Asn Thr Glu Gly Glu Ile 
865                 870                 875                 880 


Ala Ile Ala Ile Thr Asp Thr Asn Asn Lys Ile Pro Arg Ala Glu Thr 
                885                 890                 895     


Asp Met Phe Pro Ser Glu Glu Arg Ile Tyr Glu Asn Ala Pro Asn Gly 
            900                 905                 910         


Thr Lys Ile Thr Thr Ile Ile Ala Ser Asp Gln Asp Arg Asp Arg Pro 
        915                 920                 925             


Asn Asn Ala Leu Thr Tyr Arg Ile Asn Tyr Ala Phe Asn His Arg Leu 
    930                 935                 940                 


Glu Asn Phe Phe Ala Val Asp Pro Asp Thr Gly Glu Leu Phe Val His 
945                 950                 955                 960 


Phe Thr Thr Ser Glu Val Leu Asp Arg Asp Gly Glu Glu Pro Glu His 
                965                 970                 975     


Arg Ile Ile Phe Thr Ile Val Asp Asn Leu Glu Gly Ala Gly Asp Gly 
            980                 985                 990         


Asn Gln Asn Thr Ile Ser Thr Glu  Val Arg Val Ile Leu  Leu Asp Ile 
        995                 1000                 1005             


Asn Asp  Asn Lys Pro Glu Leu  Pro Ile Pro Asp Gly  Glu Phe Trp 
    1010                 1015                 1020             


Thr Val  Ser Glu Gly Glu Val  Glu Gly Lys Arg Ile  Pro Pro Glu 
    1025                 1030                 1035             


Ile His  Ala His Asp Arg Asp  Glu Pro Phe Asn Asp  Asn Ser Arg 
    1040                 1045                 1050             


Val Gly  Tyr Glu Ile Arg Ser  Ile Lys Leu Ile Asn  Arg Asp Ile 
    1055                 1060                 1065             


Glu Leu  Pro Gln Asp Pro Phe  Lys Ile Ile Thr Ile  Asp Asp Leu 
    1070                 1075                 1080             


Asp Thr  Trp Lys Phe Val Gly  Glu Leu Glu Thr Thr  Met Asp Leu 
    1085                 1090                 1095             


Arg Gly  Tyr Trp Gly Thr Tyr  Asp Val Glu Ile Arg  Ala Phe Asp 
    1100                 1105                 1110             


His Gly  Val Pro Met Leu Asp  Ser Phe Glu Thr Tyr  Gln Leu Thr 
    1115                 1120                 1125             


Val Arg  Pro Tyr Asn Phe His  Ser Pro Val Phe Val  Phe Pro Thr 
    1130                 1135                 1140             


Pro Gly  Ser Thr Ile Arg Leu  Ser Arg Glu Arg Ala  Ile Val Asn 
    1145                 1150                 1155             


Gly Met  Leu Ala Leu Ala Asn  Ile Ala Ser Gly Glu  Phe Leu Asp 
    1160                 1165                 1170             


Arg Leu  Ser Ala Thr Asp Glu  Asp Gly Leu His Ala  Gly Arg Val 
    1175                 1180                 1185             


Thr Phe  Ser Ile Ala Gly Asn  Asp Glu Ala Ala Glu  Tyr Phe Asn 
    1190                 1195                 1200             


Val Leu  Asn Asp Gly Asp Asn  Ser Ala Met Leu Thr  Leu Lys Gln 
    1205                 1210                 1215             


Ala Leu  Pro Ala Gly Val Gln  Gln Phe Glu Leu Val  Ile Arg Ala 
    1220                 1225                 1230             


Thr Asp  Gly Gly Thr Glu Pro  Gly Pro Arg Ser Thr  Asp Cys Ser 
    1235                 1240                 1245             


Val Thr  Val Val Phe Val Met  Thr Gln Gly Asp Pro  Val Phe Asp 
    1250                 1255                 1260             


Asp Asn  Ala Ala Ser Val Arg  Phe Val Glu Lys Glu  Ala Gly Met 
    1265                 1270                 1275             


Ser Glu  Arg Phe Gln Leu Pro  Gln Ala Asp Asp Pro  Lys Asn Tyr 
    1280                 1285                 1290             


Arg Cys  Met Asp Asp Cys His  Thr Ile Tyr Tyr Ser  Ile Val Asp 
    1295                 1300                 1305             


Gly Asn  Asp Gly Asp His Phe  Ala Val Glu Pro Glu  Thr Asn Val 
    1310                 1315                 1320             


Ile Tyr  Leu Leu Lys Pro Leu  Asp Arg Ser Gln Gln  Glu Gln Tyr 
    1325                 1330                 1335             


Arg Val  Val Val Ala Ala Ser  Asn Thr Pro Gly Gly  Thr Ser Thr 
    1340                 1345                 1350             


Leu Ser  Ser Ser Leu Leu Thr  Val Thr Ile Gly Val  Arg Glu Ala 
    1355                 1360                 1365             


Asn Pro  Arg Pro Ile Phe Glu  Ser Glu Phe Tyr Thr  Ala Gly Val 
    1370                 1375                 1380             


Leu His  Thr Asp Ser Ile His  Lys Glu Leu Val Tyr  Leu Ala Ala 
    1385                 1390                 1395             


Lys His  Ser Glu Gly Leu Pro  Ile Val Tyr Ser Ile  Asp Gln Glu 
    1400                 1405                 1410             


Thr Met  Lys Ile Asp Glu Ser  Leu Gln Thr Val Val  Glu Asp Ala 
    1415                 1420                 1425             


Phe Asp  Ile Asn Ser Ala Thr  Gly Val Ile Ser Leu  Asn Phe Gln 
    1430                 1435                 1440             


Pro Thr  Ser Val Met His Gly  Ser Phe Asp Phe Glu  Val Val Ala 
    1445                 1450                 1455             


Ser Asp  Thr Arg Gly Ala Ser  Asp Arg Ala Lys Val  Ser Ile Tyr 
    1460                 1465                 1470             


Met Ile  Ser Thr Arg Val Arg  Val Ala Phe Leu Phe  Tyr Asn Thr 
    1475                 1480                 1485             


Glu Ala  Glu Val Asn Glu Arg  Arg Asn Phe Ile Ala  Gln Thr Phe 
    1490                 1495                 1500             


Ala Asn  Ala Phe Gly Met Thr  Cys Asn Ile Asp Ser  Val Leu Pro 
    1505                 1510                 1515             


Ala Thr  Asp Ala Asn Gly Val  Ile Arg Glu Gly Tyr  Thr Glu Leu 
    1520                 1525                 1530             


Gln Ala  His Phe Ile Arg Asp  Asp Gln Pro Val Pro  Ala Asp Tyr 
    1535                 1540                 1545             


Ile Glu  Gly Leu Phe Thr Glu  Leu Asn Thr Leu Arg  Asp Ile Arg 
    1550                 1555                 1560             


Glu Val  Leu Ser Thr Gln Gln  Leu Thr Leu Leu Asp  Phe Ala Ala 
    1565                 1570                 1575             


Gly Gly  Ser Thr Val Leu Pro  Gly Gly Glu Tyr Ala  Leu Ala Val 
    1580                 1585                 1590             


Tyr Ile  Leu Ala Gly Ile Ala  Ala Leu Leu Ala Val  Ile Cys Leu 
    1595                 1600                 1605             


Ala Leu  Leu Ile Ala Phe Phe  Ile Arg Thr Arg Ala  Leu Asn Arg 
    1610                 1615                 1620             


Arg Leu  Glu Ala Leu Ser Met  Thr Lys Tyr Gly Ser  Val Asp Ser 
    1625                 1630                 1635             


Gly Leu  Asn Arg Ala Gly Leu  Ala Ala Pro Gly Thr  Asn Lys His 
    1640                 1645                 1650             


Ala Ile  Glu Gly Ser Asn Pro  Ile Trp Asn Glu Thr  Ile Lys Ala 
    1655                 1660                 1665             


Pro Asp  Phe Asp Ala Ile Ser  Asp Val Ser Asn Asp  Ser Asp Leu 
    1670                 1675                 1680             


Ile Gly  Ile Glu Asp Leu Pro  Gln Phe Arg Ser Asp  Tyr Phe Pro 
    1685                 1690                 1695             


Pro Gly  Asp Asp His Ser Leu  Gln Gly Ile Val Leu  Asp Asn Gln 
    1700                 1705                 1710             


Asn Asn  Asp Thr Val Ala Thr  His Gly Asn Asn Phe  Lys Phe Asn 
    1715                 1720                 1725             


Ala Ser  Pro Phe Ser Pro Glu  Phe Gly Asn Thr Pro  Ile Arg Arg 
    1730                 1735                 1740             


