                               SEQUENCE LISTING

<110> UNIVERSITY OF WASHINGTON
 
<120> METHODS FOR MAXIMIZING THE EFFICIENCY OF TARGETED GENE CORRECTION

<130> 034186-087341-PCT

<140> PCT/US2016/042463
<141> 2016-07-15

<150> 62/194,049
<151> 2015-07-17

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 240
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cctcgaccgt gaggaggttt       60

ctctgtaaag ctaagagctc acctacggca agctgaccct gaagttcatc tgcaccaccg      120

acctgccgct gcatttgccg gtgttcaagt cgcacaggcc ggagctggca ctcctccaaa      180

gagacatttc gattctcgag tggatgccgt tcgactggga cttcaagtag acgtggtggc      240


<210> 2
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
acctgccgct gcatttgccg gtgttcaagt cgcacaggcc gctcccactc ccgctacggt       60

ggatgccgtt cgactgggac ttcaagtaga cgtggtggc                              99


<210> 3
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t or g 

<400> 3
ngg                                                                      3


<210> 4
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 4
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 5
<211> 340
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ser Arg Ser 
65                  70                  75                  80  


Val Ala Arg Leu Glu Cys Asn Ser Val Ile Leu Val Tyr Cys Thr Leu 
                85                  90                  95      


Arg Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Val 
            100                 105                 110         


Gly Thr Thr Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
        115                 120                 125             


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
    130                 135                 140                 


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
145                 150                 155                 160 


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
                165                 170                 175     


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
            180                 185                 190         


Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
        195                 200                 205             


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
    210                 215                 220                 


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
225                 230                 235                 240 


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
                245                 250                 255     


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
            260                 265                 270         


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
305                 310                 315                 320 


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
                325                 330                 335     


Asp Ala Lys Asp 
            340 


<210> 6
<211> 2147
<212> DNA
<213> Homo sapiens

<400> 6
gaaagccgct ggcggaccgc gcgcagcggc cagagaccga gccctaagga gagtgcggcg       60

cttcccgagg cgtgcagctg ggaactgcaa ctcatctggg ttgtgcgcag aaggctgggg      120

caagcgagta gagaagtgga gctaatggca atgcagatgc agcttgaagc aaatgcagat      180

acttcagtgg aagaagaaag ctttggccca caacccattt cacggttaga gcagtgtggc      240

ataaatgcca acgatgtgaa gaaattggaa gaagctggat tccatactgt ggaggctgtt      300

gcctatgcgc caaagaagga gctaataaat attaagggaa ttagtgaagc caaagctgat      360

aaaattctga cggagtctcg ctctgttgcc aggctggagt gcaatagcgt gatcttggtc      420

tactgcaccc tccgcctctc aggttcaagt gattctcctg cctcagcctc ccgagtagtt      480

gggactacag gtggaattga gactggatct atcacagaaa tgtttggaga attccgaact      540

gggaagaccc agatctgtca tacgctagct gtcacctgcc agcttcccat tgaccggggt      600

ggaggtgaag gaaaggccat gtacattgac actgagggta cctttaggcc agaacggctg      660

ctggcagtgg ctgagaggta tggtctctct ggcagtgatg tcctggataa tgtagcatat      720

gctcgagcgt tcaacacaga ccaccagacc cagctccttt atcaagcatc agccatgatg      780

gtagaatcta ggtatgcact gcttattgta gacagtgcca ccgcccttta cagaacagac      840

tactcgggtc gaggtgagct ttcagccagg cagatgcact tggccaggtt tctgcggatg      900

cttctgcgac tcgctgatga gtttggtgta gcagtggtaa tcactaatca ggtggtagct      960

caagtggatg gagcagcgat gtttgctgct gatcccaaaa aacctattgg aggaaatatc     1020

atcgcccatg catcaacaac cagattgtat ctgaggaaag gaagagggga aaccagaatc     1080

tgcaaaatct acgactctcc ctgtcttcct gaagctgaag ctatgttcgc cattaatgca     1140

gatggagtgg gagatgccaa agactgaatc attgggtttt tcctctgtta aaaaccttaa     1200

gtgctgcagc ctaatgagag tgcactgctc cctggggttc tctacaggcc tcttcctgtt     1260

gtgactgcca ggataaagct tccgggaaaa cagctattat atcagctttt ctgatggtat     1320

aaacaggaga caggtcagta gtcacaaact gatctaaaat gtttattcct tctgtagtgt     1380

attaatctct gtgtgttttc tttggttttg gaggaggggt atgaagtatc tttgacatgg     1440

tgccttagga atgacttggg tttaacaagc tgtctactgg acaatcttat gtttccaaga     1500

gaactaaagc tggagagacc tgacccttct ctcacttcta aattaatggt aaaataaaat     1560

gcctcagcta tgtagcaaag ggaatgggtc tgcacagatt ctttttttct gtcagtaaaa     1620

ctctcaagca ggtttttaag ttgtctgtct gaatgatctt gtgtaaggtt ttggttatgg     1680

agtcttgtgc caaacctact aggccattag cccttcacca tctacctgct tggtctttca     1740

ttgctaagac taactcaaga taatcctaga gtcttaaagc atttcaggcc agtgtggtgt     1800

cttgcgcctg tactcccagc actttgggag gccgaggcag gtggatcgct tgagcccagg     1860

agttttaagt ccagcttggc caaggtggtg aaatcccatc tctacaaaaa atgcagaact     1920

taatctggac acactgttac acgtgcctgt agtcccagct actcgatagc ctgaggtggg     1980

agaatcactt aagcctggaa ggtggaagtt gcagtgagtc gagattgcac tgctgcattc     2040

cagccagggt gacagagtga gaccatgttt caaacaagaa acatttcaga gggtaagtaa     2100

acagatttga ttgtgaggct tctaataaag tagttattag tagtgaa                   2147


<210> 7
<211> 3418
<212> PRT
<213> Homo sapiens

<400> 7
Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210> 8
<211> 11386
<212> DNA
<213> Homo sapiens

<400> 8
gtggcgcgag cttctgaaac taggcggcag aggcggagcc gctgtggcac tgctgcgcct       60

ctgctgcgcc tcgggtgtct tttgcggcgg tgggtcgccg ccgggagaag cgtgagggga      120

cagatttgtg accggcgcgg tttttgtcag cttactccgg ccaaaaaaga actgcacctc      180

tggagcggac ttatttacca agcattggag gaatatcgta ggtaaaaatg cctattggat      240

ccaaagagag gccaacattt tttgaaattt ttaagacacg ctgcaacaaa gcagatttag      300

gaccaataag tcttaattgg tttgaagaac tttcttcaga agctccaccc tataattctg      360

aacctgcaga agaatctgaa cataaaaaca acaattacga accaaaccta tttaaaactc      420

cacaaaggaa accatcttat aatcagctgg cttcaactcc aataatattc aaagagcaag      480

ggctgactct gccgctgtac caatctcctg taaaagaatt agataaattc aaattagact      540

taggaaggaa tgttcccaat agtagacata aaagtcttcg cacagtgaaa actaaaatgg      600

atcaagcaga tgatgtttcc tgtccacttc taaattcttg tcttagtgaa agtcctgttg      660

ttctacaatg tacacatgta acaccacaaa gagataagtc agtggtatgt gggagtttgt      720

ttcatacacc aaagtttgtg aagggtcgtc agacaccaaa acatatttct gaaagtctag      780

gagctgaggt ggatcctgat atgtcttggt caagttcttt agctacacca cccaccctta      840

gttctactgt gctcatagtc agaaatgaag aagcatctga aactgtattt cctcatgata      900

ctactgctaa tgtgaaaagc tatttttcca atcatgatga aagtctgaag aaaaatgata      960

gatttatcgc ttctgtgaca gacagtgaaa acacaaatca aagagaagct gcaagtcatg     1020

gatttggaaa aacatcaggg aattcattta aagtaaatag ctgcaaagac cacattggaa     1080

agtcaatgcc aaatgtccta gaagatgaag tatatgaaac agttgtagat acctctgaag     1140

aagatagttt ttcattatgt ttttctaaat gtagaacaaa aaatctacaa aaagtaagaa     1200

ctagcaagac taggaaaaaa attttccatg aagcaaacgc tgatgaatgt gaaaaatcta     1260

aaaaccaagt gaaagaaaaa tactcatttg tatctgaagt ggaaccaaat gatactgatc     1320

cattagattc aaatgtagca aatcagaagc cctttgagag tggaagtgac aaaatctcca     1380

aggaagttgt accgtctttg gcctgtgaat ggtctcaact aaccctttca ggtctaaatg     1440

gagcccagat ggagaaaata cccctattgc atatttcttc atgtgaccaa aatatttcag     1500

aaaaagacct attagacaca gagaacaaaa gaaagaaaga ttttcttact tcagagaatt     1560

ctttgccacg tatttctagc ctaccaaaat cagagaagcc attaaatgag gaaacagtgg     1620

taaataagag agatgaagag cagcatcttg aatctcatac agactgcatt cttgcagtaa     1680

agcaggcaat atctggaact tctccagtgg cttcttcatt tcagggtatc aaaaagtcta     1740

tattcagaat aagagaatca cctaaagaga ctttcaatgc aagtttttca ggtcatatga     1800

ctgatccaaa ctttaaaaaa gaaactgaag cctctgaaag tggactggaa atacatactg     1860

tttgctcaca gaaggaggac tccttatgtc caaatttaat tgataatgga agctggccag     1920

ccaccaccac acagaattct gtagctttga agaatgcagg tttaatatcc actttgaaaa     1980

agaaaacaaa taagtttatt tatgctatac atgatgaaac atcttataaa ggaaaaaaaa     2040

taccgaaaga ccaaaaatca gaactaatta actgttcagc ccagtttgaa gcaaatgctt     2100

ttgaagcacc acttacattt gcaaatgctg attcaggttt attgcattct tctgtgaaaa     2160

gaagctgttc acagaatgat tctgaagaac caactttgtc cttaactagc tcttttggga     2220

caattctgag gaaatgttct agaaatgaaa catgttctaa taatacagta atctctcagg     2280

atcttgatta taaagaagca aaatgtaata aggaaaaact acagttattt attaccccag     2340

aagctgattc tctgtcatgc ctgcaggaag gacagtgtga aaatgatcca aaaagcaaaa     2400

aagtttcaga tataaaagaa gaggtcttgg ctgcagcatg tcacccagta caacattcaa     2460

aagtggaata cagtgatact gactttcaat cccagaaaag tcttttatat gatcatgaaa     2520

atgccagcac tcttatttta actcctactt ccaaggatgt tctgtcaaac ctagtcatga     2580

tttctagagg caaagaatca tacaaaatgt cagacaagct caaaggtaac aattatgaat     2640

ctgatgttga attaaccaaa aatattccca tggaaaagaa tcaagatgta tgtgctttaa     2700

atgaaaatta taaaaacgtt gagctgttgc cacctgaaaa atacatgaga gtagcatcac     2760

cttcaagaaa ggtacaattc aaccaaaaca caaatctaag agtaatccaa aaaaatcaag     2820

aagaaactac ttcaatttca aaaataactg tcaatccaga ctctgaagaa cttttctcag     2880

acaatgagaa taattttgtc ttccaagtag ctaatgaaag gaataatctt gctttaggaa     2940

atactaagga acttcatgaa acagacttga cttgtgtaaa cgaacccatt ttcaagaact     3000

ctaccatggt tttatatgga gacacaggtg ataaacaagc aacccaagtg tcaattaaaa     3060

aagatttggt ttatgttctt gcagaggaga acaaaaatag tgtaaagcag catataaaaa     3120

tgactctagg tcaagattta aaatcggaca tctccttgaa tatagataaa ataccagaaa     3180

aaaataatga ttacatgaac aaatgggcag gactcttagg tccaatttca aatcacagtt     3240

ttggaggtag cttcagaaca gcttcaaata aggaaatcaa gctctctgaa cataacatta     3300

agaagagcaa aatgttcttc aaagatattg aagaacaata tcctactagt ttagcttgtg     3360

ttgaaattgt aaataccttg gcattagata atcaaaagaa actgagcaag cctcagtcaa     3420

ttaatactgt atctgcacat ttacagagta gtgtagttgt ttctgattgt aaaaatagtc     3480

atataacccc tcagatgtta ttttccaagc aggattttaa ttcaaaccat aatttaacac     3540

ctagccaaaa ggcagaaatt acagaacttt ctactatatt agaagaatca ggaagtcagt     3600

ttgaatttac tcagtttaga aaaccaagct acatattgca gaagagtaca tttgaagtgc     3660

ctgaaaacca gatgactatc ttaaagacca cttctgagga atgcagagat gctgatcttc     3720

atgtcataat gaatgcccca tcgattggtc aggtagacag cagcaagcaa tttgaaggta     3780

cagttgaaat taaacggaag tttgctggcc tgttgaaaaa tgactgtaac aaaagtgctt     3840

ctggttattt aacagatgaa aatgaagtgg ggtttagggg cttttattct gctcatggca     3900

caaaactgaa tgtttctact gaagctctgc aaaaagctgt gaaactgttt agtgatattg     3960

agaatattag tgaggaaact tctgcagagg tacatccaat aagtttatct tcaagtaaat     4020

gtcatgattc tgttgtttca atgtttaaga tagaaaatca taatgataaa actgtaagtg     4080

aaaaaaataa taaatgccaa ctgatattac aaaataatat tgaaatgact actggcactt     4140

ttgttgaaga aattactgaa aattacaaga gaaatactga aaatgaagat aacaaatata     4200

ctgctgccag tagaaattct cataacttag aatttgatgg cagtgattca agtaaaaatg     4260

atactgtttg tattcataaa gatgaaacgg acttgctatt tactgatcag cacaacatat     4320

gtcttaaatt atctggccag tttatgaagg agggaaacac tcagattaaa gaagatttgt     4380

cagatttaac ttttttggaa gttgcgaaag ctcaagaagc atgtcatggt aatacttcaa     4440

ataaagaaca gttaactgct actaaaacgg agcaaaatat aaaagatttt gagacttctg     4500

atacattttt tcagactgca agtgggaaaa atattagtgt cgccaaagag tcatttaata     4560

aaattgtaaa tttctttgat cagaaaccag aagaattgca taacttttcc ttaaattctg     4620

aattacattc tgacataaga aagaacaaaa tggacattct aagttatgag gaaacagaca     4680

tagttaaaca caaaatactg aaagaaagtg tcccagttgg tactggaaat caactagtga     4740

ccttccaggg acaacccgaa cgtgatgaaa agatcaaaga acctactcta ttgggttttc     4800

atacagctag cgggaaaaaa gttaaaattg caaaggaatc tttggacaaa gtgaaaaacc     4860

tttttgatga aaaagagcaa ggtactagtg aaatcaccag ttttagccat caatgggcaa     4920

agaccctaaa gtacagagag gcctgtaaag accttgaatt agcatgtgag accattgaga     4980

tcacagctgc cccaaagtgt aaagaaatgc agaattctct caataatgat aaaaaccttg     5040

tttctattga gactgtggtg ccacctaagc tcttaagtga taatttatgt agacaaactg     5100

aaaatctcaa aacatcaaaa agtatctttt tgaaagttaa agtacatgaa aatgtagaaa     5160

aagaaacagc aaaaagtcct gcaacttgtt acacaaatca gtccccttat tcagtcattg     5220

aaaattcagc cttagctttt tacacaagtt gtagtagaaa aacttctgtg agtcagactt     5280

cattacttga agcaaaaaaa tggcttagag aaggaatatt tgatggtcaa ccagaaagaa     5340

taaatactgc agattatgta ggaaattatt tgtatgaaaa taattcaaac agtactatag     5400

ctgaaaatga caaaaatcat ctctccgaaa aacaagatac ttatttaagt aacagtagca     5460

tgtctaacag ctattcctac cattctgatg aggtatataa tgattcagga tatctctcaa     5520

aaaataaact tgattctggt attgagccag tattgaagaa tgttgaagat caaaaaaaca     5580

ctagtttttc caaagtaata tccaatgtaa aagatgcaaa tgcataccca caaactgtaa     5640

atgaagatat ttgcgttgag gaacttgtga ctagctcttc accctgcaaa aataaaaatg     5700

cagccattaa attgtccata tctaatagta ataattttga ggtagggcca cctgcattta     5760

ggatagccag tggtaaaatc gtttgtgttt cacatgaaac aattaaaaaa gtgaaagaca     5820

tatttacaga cagtttcagt aaagtaatta aggaaaacaa cgagaataaa tcaaaaattt     5880

gccaaacgaa aattatggca ggttgttacg aggcattgga tgattcagag gatattcttc     5940

ataactctct agataatgat gaatgtagca cgcattcaca taaggttttt gctgacattc     6000

agagtgaaga aattttacaa cataaccaaa atatgtctgg attggagaaa gtttctaaaa     6060

tatcaccttg tgatgttagt ttggaaactt cagatatatg taaatgtagt atagggaagc     6120

ttcataagtc agtctcatct gcaaatactt gtgggatttt tagcacagca agtggaaaat     6180

ctgtccaggt atcagatgct tcattacaaa acgcaagaca agtgttttct gaaatagaag     6240

atagtaccaa gcaagtcttt tccaaagtat tgtttaaaag taacgaacat tcagaccagc     6300

tcacaagaga agaaaatact gctatacgta ctccagaaca tttaatatcc caaaaaggct     6360

tttcatataa tgtggtaaat tcatctgctt tctctggatt tagtacagca agtggaaagc     6420

aagtttccat tttagaaagt tccttacaca aagttaaggg agtgttagag gaatttgatt     6480

taatcagaac tgagcatagt cttcactatt cacctacgtc tagacaaaat gtatcaaaaa     6540

tacttcctcg tgttgataag agaaacccag agcactgtgt aaactcagaa atggaaaaaa     6600

cctgcagtaa agaatttaaa ttatcaaata acttaaatgt tgaaggtggt tcttcagaaa     6660

ataatcactc tattaaagtt tctccatatc tctctcaatt tcaacaagac aaacaacagt     6720

tggtattagg aaccaaagtg tcacttgttg agaacattca tgttttggga aaagaacagg     6780

cttcacctaa aaacgtaaaa atggaaattg gtaaaactga aactttttct gatgttcctg     6840

tgaaaacaaa tatagaagtt tgttctactt actccaaaga ttcagaaaac tactttgaaa     6900

cagaagcagt agaaattgct aaagctttta tggaagatga tgaactgaca gattctaaac     6960

tgccaagtca tgccacacat tctcttttta catgtcccga aaatgaggaa atggttttgt     7020

caaattcaag aattggaaaa agaagaggag agccccttat cttagtggga gaaccctcaa     7080

tcaaaagaaa cttattaaat gaatttgaca ggataataga aaatcaagaa aaatccttaa     7140

aggcttcaaa aagcactcca gatggcacaa taaaagatcg aagattgttt atgcatcatg     7200

tttctttaga gccgattacc tgtgtaccct ttcgcacaac taaggaacgt caagagatac     7260

agaatccaaa ttttaccgca cctggtcaag aatttctgtc taaatctcat ttgtatgaac     7320

atctgacttt ggaaaaatct tcaagcaatt tagcagtttc aggacatcca ttttatcaag     7380

tttctgctac aagaaatgaa aaaatgagac acttgattac tacaggcaga ccaaccaaag     7440

tctttgttcc accttttaaa actaaatcac attttcacag agttgaacag tgtgttagga     7500

atattaactt ggaggaaaac agacaaaagc aaaacattga tggacatggc tctgatgata     7560

gtaaaaataa gattaatgac aatgagattc atcagtttaa caaaaacaac tccaatcaag     7620

cagcagctgt aactttcaca aagtgtgaag aagaaccttt agatttaatt acaagtcttc     7680

agaatgccag agatatacag gatatgcgaa ttaagaagaa acaaaggcaa cgcgtctttc     7740

cacagccagg cagtctgtat cttgcaaaaa catccactct gcctcgaatc tctctgaaag     7800

cagcagtagg aggccaagtt ccctctgcgt gttctcataa acagctgtat acgtatggcg     7860

tttctaaaca ttgcataaaa attaacagca aaaatgcaga gtcttttcag tttcacactg     7920

aagattattt tggtaaggaa agtttatgga ctggaaaagg aatacagttg gctgatggtg     7980

gatggctcat accctccaat gatggaaagg ctggaaaaga agaattttat agggctctgt     8040

gtgacactcc aggtgtggat ccaaagctta tttctagaat ttgggtttat aatcactata     8100

gatggatcat atggaaactg gcagctatgg aatgtgcctt tcctaaggaa tttgctaata     8160

gatgcctaag cccagaaagg gtgcttcttc aactaaaata cagatatgat acggaaattg     8220

atagaagcag aagatcggct ataaaaaaga taatggaaag ggatgacaca gctgcaaaaa     8280

cacttgttct ctgtgtttct gacataattt cattgagcgc aaatatatct gaaacttcta     8340

gcaataaaac tagtagtgca gatacccaaa aagtggccat tattgaactt acagatgggt     8400

ggtatgctgt taaggcccag ttagatcctc ccctcttagc tgtcttaaag aatggcagac     8460

tgacagttgg tcagaagatt attcttcatg gagcagaact ggtgggctct cctgatgcct     8520

gtacacctct tgaagcccca gaatctctta tgttaaagat ttctgctaac agtactcggc     8580

ctgctcgctg gtataccaaa cttggattct ttcctgaccc tagacctttt cctctgccct     8640

tatcatcgct tttcagtgat ggaggaaatg ttggttgtgt tgatgtaatt attcaaagag     8700

cataccctat acagtggatg gagaagacat catctggatt atacatattt cgcaatgaaa     8760

gagaggaaga aaaggaagca gcaaaatatg tggaggccca acaaaagaga ctagaagcct     8820

tattcactaa aattcaggag gaatttgaag aacatgaaga aaacacaaca aaaccatatt     8880

taccatcacg tgcactaaca agacagcaag ttcgtgcttt gcaagatggt gcagagcttt     8940

atgaagcagt gaagaatgca gcagacccag cttaccttga gggttatttc agtgaagagc     9000

agttaagagc cttgaataat cacaggcaaa tgttgaatga taagaaacaa gctcagatcc     9060

agttggaaat taggaaggcc atggaatctg ctgaacaaaa ggaacaaggt ttatcaaggg     9120

atgtcacaac cgtgtggaag ttgcgtattg taagctattc aaaaaaagaa aaagattcag     9180

ttatactgag tatttggcgt ccatcatcag atttatattc tctgttaaca gaaggaaaga     9240

gatacagaat ttatcatctt gcaacttcaa aatctaaaag taaatctgaa agagctaaca     9300

tacagttagc agcgacaaaa aaaactcagt atcaacaact accggtttca gatgaaattt     9360

tatttcagat ttaccagcca cgggagcccc ttcacttcag caaattttta gatccagact     9420

ttcagccatc ttgttctgag gtggacctaa taggatttgt cgtttctgtt gtgaaaaaaa     9480

caggacttgc ccctttcgtc tatttgtcag acgaatgtta caatttactg gcaataaagt     9540

tttggataga ccttaatgag gacattatta agcctcatat gttaattgct gcaagcaacc     9600

tccagtggcg accagaatcc aaatcaggcc ttcttacttt atttgctgga gatttttctg     9660

tgttttctgc tagtccaaaa gagggccact ttcaagagac attcaacaaa atgaaaaata     9720

ctgttgagaa tattgacata ctttgcaatg aagcagaaaa caagcttatg catatactgc     9780

atgcaaatga tcccaagtgg tccaccccaa ctaaagactg tacttcaggg ccgtacactg     9840

ctcaaatcat tcctggtaca ggaaacaagc ttctgatgtc ttctcctaat tgtgagatat     9900

attatcaaag tcctttatca ctttgtatgg ccaaaaggaa gtctgtttcc acacctgtct     9960

cagcccagat gacttcaaag tcttgtaaag gggagaaaga gattgatgac caaaagaact    10020

gcaaaaagag aagagccttg gatttcttga gtagactgcc tttacctcca cctgttagtc    10080

ccatttgtac atttgtttct ccggctgcac agaaggcatt tcagccacca aggagttgtg    10140

gcaccaaata cgaaacaccc ataaagaaaa aagaactgaa ttctcctcag atgactccat    10200

ttaaaaaatt caatgaaatt tctcttttgg aaagtaattc aatagctgac gaagaacttg    10260

cattgataaa tacccaagct cttttgtctg gttcaacagg agaaaaacaa tttatatctg    10320

tcagtgaatc cactaggact gctcccacca gttcagaaga ttatctcaga ctgaaacgac    10380

gttgtactac atctctgatc aaagaacagg agagttccca ggccagtacg gaagaatgtg    10440

agaaaaataa gcaggacaca attacaacta aaaaatatat ctaagcattt gcaaaggcga    10500

caataaatta ttgacgctta acctttccag tttataagac tggaatataa tttcaaacca    10560

cacattagta cttatgttgc acaatgagaa aagaaattag tttcaaattt acctcagcgt    10620

ttgtgtatcg ggcaaaaatc gttttgcccg attccgtatt ggtatacttt tgcttcagtt    10680

gcatatctta aaactaaatg taatttatta actaatcaag aaaaacatct ttggctgagc    10740

tcggtggctc atgcctgtaa tcccaacact ttgagaagct gaggtgggag gagtgcttga    10800

ggccaggagt tcaagaccag cctgggcaac atagggagac ccccatcttt acaaagaaaa    10860

aaaaaagggg aaaagaaaat cttttaaatc tttggatttg atcactacaa gtattatttt    10920

acaagtgaaa taaacatacc attttctttt agattgtgtc attaaatgga atgaggtctc    10980

ttagtacagt tattttgatg cagataattc cttttagttt agctactatt ttaggggatt    11040

ttttttagag gtaactcact atgaaatagt tctccttaat gcaaatatgt tggttctgct    11100

atagttccat cctgttcaaa agtcaggatg aatatgaaga gtggtgtttc cttttgagca    11160

attcttcatc cttaagtcag catgattata agaaaaatag aaccctcagt gtaactctaa    11220

ttccttttta ctattccagt gtgatctctg aaattaaatt acttcaacta aaaattcaaa    11280

tactttaaat cagaagattt catagttaat ttattttttt tttcaacaaa atggtcatcc    11340

aaactcaaac ttgagaaaat atcttgcttt caaattggca ctgatt                   11386


<210> 9
<211> 70
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Glu Lys Lys Gln Pro Val Asp Leu Gly Leu Leu Glu Glu Asp 
1               5                   10                  15      


Asp Glu Phe Glu Glu Phe Pro Ala Glu Asp Trp Ala Gly Leu Asp Glu 
            20                  25                  30          


Asp Glu Asp Ala His Val Trp Glu Asp Asn Trp Asp Asp Asp Asn Val 
        35                  40                  45              


Glu Asp Asp Phe Ser Asn Gln Leu Arg Ala Glu Leu Glu Lys His Gly 
    50                  55                  60                  


Tyr Lys Met Glu Thr Ser 
65                  70  


<210> 10
<211> 509
<212> DNA
<213> Homo sapiens

<400> 10
attctttccc caagtctcta tggtagcgtc agcgtcggag gcggtagtga cggtggcgtt       60

tccttgagga agagtgaggg ttccaacttt tctgcttatc tgggaggtgt tgggcgcgga      120

cagtcgagat gtcagagaaa aagcagccgg tagacttagg tctgttagag gaagacgacg      180

agtttgaaga gttccctgcc gaagactggg ctggcttaga tgaagatgaa gatgcacatg      240

tctgggagga taattgggat gatgacaatg tagaggatga cttctctaat cagttacgag      300

ctgaactaga gaaacatggt tataagatgg agacttcata gcatccagaa gaagtgttga      360

agtaacctaa acttgacctg cttaatacat tctagggcag agaacccagg atgggacact      420

aaaaaaatgt gtttatttca ttatctgctt ggatttattt gtgtttttgt aacacaaaaa      480

ataaatgttt tgatataaaa aaaaaaaaa                                        509


<210> 11
<211> 1186
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210> 12
<211> 4069
<212> DNA
<213> Homo sapiens

<400> 12
gcaggccgaa tggtggattt aattggccgg agtttagggc gcgcttggcc cgcgtgggtc       60

agctgatcgc gcactgaggg tgcgatcccg ggctccccat tccttcctgg ggcgcctccc      120

cggcccaggg ccaactgggt cccggtgtcg gcaggcctgg ggtcggcgac ggctgctctt      180

ttcgttctgt cgcctgcccg atggacgagc ctcccgggaa gcccctcagc tgtgaggaga      240

aggaaaagtt aaaggagaaa ttagcattct tgaaaaggga atacagcaag acactagccc      300

gccttcagcg tgcccaaaga gctgaaaaga ttaagcattc tattaagaaa acagtagaag      360

aacaagattg tttgtctcag caggatctct caccgcagct aaaacactca gaacctaaaa      420

ataaaatatg tgtttatgac aagttacaca tcaaaaccca tcttgatgaa gaaactggag      480

aaaagacatc tatcacactt gatgttgggc ctgagtcctt taaccctgga gatggcccag      540

gaggattacc tatacaaaga acagatgaca cccaagaaca ttttccccac agggtcagtg      600

accctagtgg tgagcaaaag cagaagctgc caagcagaag aaagaagcag cagaagagga      660

catttatttc acaggagaga gactgtgtct ttggcactga ttcactcaga ttgtctggga      720

aaagactaaa ggaacaggaa gaaatcagta gcaaaaatcc tgctagatca ccagtaactg      780

aaataagaac tcacctttta agtcttaaat ctgaacttcc agattctcca gaaccagtta      840

cagaaattaa tgaagacagt gtattaattc caccaactgc ccaaccagaa aaaggtgttg      900

atacattcct aagaagacct aatttcacca gggcgactac agttccttta cagactctat      960

cagatagcgg tagtagtcag caccttgaac acattcctcc taaaggtagc agtgaactta     1020

ctactcacga cctaaaaaac attagattta cttcacctgt aagtttggag gcacaaggca     1080

aaaaaatgac tgtctctaca gataacctcc ttgtaaataa agctataagt aaaagtggcc     1140

aactgcccac aagttctaat ttagaggcaa atatttcatg ttctctaaat gaactcacct     1200

acaataactt accagcaaat gaaaaccaaa acttaaaaga acaaaatcaa acagagaaat     1260

ctttaaaatc tcccagtgac actcttgatg gcaggaatga aaatcttcag gaaagtgaga     1320

ttctaagtca acctaagagt cttagcctgg aagcaacctc tcctctttct gcagaaaaac     1380

attcttgcac agtgcctgaa ggccttctgt ttcctgcaga atattatgtt agaacaacac     1440

gaagcatgtc caattgccag aggaaagtag ccgtggaggc tgtcattcag agtcatttgg     1500

atgtcaagaa aaaagggttt aaaaataaaa ataaggatgc aagtaaaaat ttaaaccttt     1560

ccaatgagga aactgaccaa agtgaaatta ggatgtctgg cacatgcaca ggacaaccaa     1620

gttcaagaac ctctcagaaa cttctctcat taactaaagt cagctctccc gctgggccca     1680

ctgaagataa tgacttgtct aggaaggcag ttgcccaagc acctggtaga agatacacag     1740

gaaaaagaaa atcagcctgc accccagcat cagatcattg tgaaccactt ttgccaactt     1800

ctagcctgtc gattgttaac aggtccaagg aagaagtcac ctcacacaaa tatcagcacg     1860

aaaaattatt tattcaagtg aaagggaaga aaagtcgtca tcaaaaagag gattcccttt     1920

cttggagtaa tagtgcttat ttatccttgg atgatgatgc tttcacggct ccatttcata     1980

gggatggaat gctgagttta aagcaactac tgtcttttct cagtatcaca gactttcagt     2040

tacctgatga agactttgga cctcttaagc ttgaaaaagt gaagtcctgc tcagaaaaac     2100

cagtggagcc ctttgagtca aaaatgtttg gagagagaca tcttaaagag ggaagctgta     2160

tttttccaga ggaactgagt cctaaacgca tggatacaga aatggaggac ttagaagagg     2220

accttattgt tctaccagga aaatcacatc ccaaaaggcc aaactcgcaa agccagcata     2280

caaagacggg cctttcttca tccatattac tttatactcc tttaaatacg gttgcgcctg     2340

atgataatga caggcctacc acagacatgt gttcacctgc tttccccatc ttaggtacta     2400

ctccagcctt tggccctcaa ggctcctatg aaaaagcatc tacagaagtt gctggacgaa     2460

cttgctgcac accccaactt gctcatttga aagactcagt ctgtcttgcc agtgatacta     2520

aacaattcga cagttcaggc agcccagcaa aaccacatac caccctgcaa gtgtcaggca     2580

ggcaaggaca acctacctgt gactgtgact ctgtcccgcc aggaacacct ccacccattg     2640

agtcattcac ttttaaagaa aatcagctct gtagaaacac atgccaggag ctgcataaac     2700

attccgtcga acagactgaa acagcagagc ttcctgcttc tgatagcata aacccaggca     2760

acctacaatt ggtttcagag ttaaagaatc cttcaggttc ctgttccgta gatgtgagtg     2820

ccatgttttg ggaaagagcc ggttgtaaag agccatgtat cataactgct tgcgaagatg     2880

tagtttctct ttggaaagct ctggatgctt ggcagtggga aaaactttat acctggcact     2940

tcgcagaggt tccagtatta cagatagttc cagtgcctga tgtgtataat ctcgtgtgtg     3000

tagctttggg aaatttggaa atcagagaga tcagggcatt gttttgttcc tctgatgatg     3060

aaagtgaaaa gcaagtacta ctgaagtctg gaaatataaa agctgtgctt ggcctgacaa     3120

agaggaggct agttagtagc agtgggaccc tttctgatca acaagtagaa gtcatgacgt     3180

ttgcagaaga tggaggaggc aaagaaaacc aatttttgat gccccctgag gagactatac     3240

taacttttgc tgaggtccaa gggatgcaag aagctctgct tggtactact attatgaaca     3300

acattgttat ttggaattta aaaactggtc aactcctgaa aaagatgcac attgatgatt     3360

cttaccaagc ttcagtctgt cacaaagcct attctgaaat ggggcttctc tttattgtcc     3420

tgagtcatcc ctgtgccaaa gagagtgagt cgttgcgaag ccctgtgttt cagctcattg     3480

tgattaaccc taagacgact ctcagcgtgg gtgtgatgct gtactgtctt cctccagggc     3540

aggctggcag gttcctggaa ggtgacgtga aagatcactg tgcagcagca atcttgactt     3600

ctggaacaat tgccatttgg gacttacttc tcggtcagtg tactgccctc ctcccacctg     3660

tctctgacca acattggtct tttgtgaaat ggtcgggtac agactctcat ttgctggctg     3720

gacaaaaaga tggaaatata tttgtatacc actattcata agttagggta aagtgaaaac     3780

acaattttct ggatatattg ggcctcttag tattttttgg agttttaaat ataaaggaga     3840

atatctgaat gacacttaaa atgattgctt gtttatgtcc agacagactt attttttatt     3900

ctaatgatgg tagcaccact gatcttggat gtacatttat gtatactttg agaaaaaggg     3960

ttttaggttg atttttgtaa tttcccacat ttgtacatgt gcttttaaag gtgtacataa     4020

agcttcaaat ggcaataaat atttattttt atacattcaa aaaaaaaaa                 4069


<210> 13
<211> 7224
<212> DNA
<213> Homo sapiens

<400> 13
gtaccttgat ttcgtattct gagaggctgc tgcttagcgg tagccccttg gtttccgtgg       60

caacggaaaa gcgcgggaat tacagataaa ttaaaactgc gactgcgcgg cgtgagctcg      120

ctgagacttc ctggacgggg gacaggctgt ggggtttctc agataactgg gcccctgcgc      180

tcaggaggcc ttcaccctct gctctgggta aagttcattg gaacagaaag aaatggattt      240

atctgctctt cgcgttgaag aagtacaaaa tgtcattaat gctatgcaga aaatcttaga      300

gtgtcccatc tgtctggagt tgatcaagga acctgtctcc acaaagtgtg accacatatt      360

ttgcaaattt tgcatgctga aacttctcaa ccagaagaaa gggccttcac agtgtccttt      420

atgtaagaat gatataacca aaaggagcct acaagaaagt acgagattta gtcaacttgt      480

tgaagagcta ttgaaaatca tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa      540

cagctataat tttgcaaaaa aggaaaataa ctctcctgaa catctaaaag atgaagtttc      600

tatcatccaa agtatgggct acagaaaccg tgccaaaaga cttctacaga gtgaacccga      660

aaatccttcc ttgcaggaaa ccagtctcag tgtccaactc tctaaccttg gaactgtgag      720

aactctgagg acaaagcagc ggatacaacc tcaaaagacg tctgtctaca ttgaattggg      780

atctgattct tctgaagata ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga      840

attgttacaa atcacccctc aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa      900

ggctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa      960

taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg     1020

tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt     1080

acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga     1140

attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg     1200

aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa     1260

tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa     1320

tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa     1380

tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc     1440

tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc     1500

tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa     1560

aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa     1620

aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat     1680

aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa     1740

gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt     1800

ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg     1860

tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca     1920

gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa     1980

agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc     2040

aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct     2100

tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag     2160

ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag     2220

cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa     2280

gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac     2340

aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa     2400

tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa     2460

tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc     2520

tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat     2580

ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag     2640

tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag     2700

aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac     2760

aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt     2820

ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc     2880

aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg     2940

tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt     3000

taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa     3060

atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac     3120

tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact     3180

ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt     3240

tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt     3300

gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa     3360

tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc     3420

cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat     3480

gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg     3540

taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga     3600

tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc     3660

tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac     3720

tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa     3780

aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg     3840

aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct     3900

tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag     3960

gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt     4020

gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca     4080

tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt     4140

ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca     4200

aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga     4260

tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc     4320

aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc     4380

agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa     4440

cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag     4500

ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg     4560

aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata     4620

ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag     4680

ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc     4740

attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc     4800

atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg     4860

gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta     4920

cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag     4980

agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc     5040

ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc     5100

tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac     5160

agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat     5220

gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga     5280

gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata     5340

ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat     5400

taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg     5460

aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg     5520

gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat     5580

ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg     5640

tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc     5700

aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc     5760

actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta     5820

ctgactgcag ccagccacag gtacagagcc acaggacccc aagaatgagc ttacaaagtg     5880

gcctttccag gccctgggag ctcctctcac tcttcagtcc ttctactgtc ctggctacta     5940

aatattttat gtacatcagc ctgaaaagga cttctggcta tgcaagggtc ccttaaagat     6000

tttctgcttg aagtctccct tggaaatctg ccatgagcac aaaattatgg taatttttca     6060

cctgagaaga ttttaaaacc atttaaacgc caccaattga gcaagatgct gattcattat     6120

ttatcagccc tattctttct attcaggctg ttgttggctt agggctggaa gcacagagtg     6180

gcttggcctc aagagaatag ctggtttccc taagtttact tctctaaaac cctgtgttca     6240

caaaggcaga gagtcagacc cttcaatgga aggagagtgc ttgggatcga ttatgtgact     6300

taaagtcaga atagtccttg ggcagttctc aaatgttgga gtggaacatt ggggaggaaa     6360

ttctgaggca ggtattagaa atgaaaagga aacttgaaac ctgggcatgg tggctcacgc     6420

ctgtaatccc agcactttgg gaggccaagg tgggcagatc actggaggtc aggagttcga     6480

aaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacagaa attagccggt     6540

catggtggtg gacacctgta atcccagcta ctcaggtggc taaggcagga gaatcacttc     6600

agcccgggag gtggaggttg cagtgagcca agatcatacc acggcactcc agcctgggtg     6660

acagtgagac tgtggctcaa aaaaaaaaaa aaaaaaagga aaatgaaact agaagagatt     6720

tctaaaagtc tgagatatat ttgctagatt tctaaagaat gtgttctaaa acagcagaag     6780

attttcaaga accggtttcc aaagacagtc ttctaattcc tcattagtaa taagtaaaat     6840

gtttattgtt gtagctctgg tatataatcc attcctctta aaatataaga cctctggcat     6900

gaatatttca tatctataaa atgacagatc ccaccaggaa ggaagctgtt gctttctttg     6960

aggtgatttt tttcctttgc tccctgttgc tgaaaccata cagcttcata aataattttg     7020

cttgctgaag gaagaaaaag tgtttttcat aaacccatta tccaggactg tttatagctg     7080

ttggaaggac taggtcttcc ctagcccccc cagtgtgcaa gggcagtgaa gacttgattg     7140

tacaaaatac gttttgtaaa tgttgtgctg ttaacactgc aaataaactt ggtagcaaac     7200

acttccaaaa aaaaaaaaaa aaaa                                            7224


<210> 14
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
cggtggtgca gatgaacttc agggtcagct tgccgtaggt ggcatcgccc tcaccctcgc       60

cggacacgct gaacttgtgg ccgtttacgt cgccgtcca                              99


<210> 15
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggtgag ggcgatgcca       60

cctacggcaa gctgaccctg aagttcatct gcaccaccg                              99


<210> 16
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
cggtggtgca gatgaacttc agggtaagct tgccgtaggt ggcatcgccc tcaccctcgc       60

cggacacgct gaatttgtgg ccgtttacgt cgccgtcca                              99


<210> 17
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
cggtggtgca gatgaacttc agggtcagct tgccgtaggt tagctcttag ctttacagag       60

aagacctgct cacggtccag gccggacacg ctgaacttgt ggccgtttac gtcgccgtcc      120

a                                                                      121


<210> 18
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
cggtggtgca gatgaacttc agggtcagct tgccgtaggt tcttcgggtc catatcccgg       60

aaagatgctc cagcatgaat gccggacacg ctgaacttgt ggccgtttac gtcgccgtcc      120

a                                                                      121


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ccaaggacct gaaatgacc                                                    19


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
gtcctccttg aagtcgatgc                                                   20


