                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  HER3 Antibodies

<130>  X20638

<150>  62/194615
<151>  2015-07-20

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Thr Tyr 
            20                  25                  30          


Thr Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Val Thr Tyr Asn Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Trp Gly Asp Gln Asn Gly Leu Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Thr Tyr 
            20                  25                  30          


Thr Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Val Thr Tyr Asn Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Trp Gly Asp Gln Asn Gly Leu Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Arg Val Tyr Gly Asn 
            20                  25                  30          


Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Phe Ala Arg Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Gly 
                85                  90                  95      


Thr Asn Trp Tyr Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Arg Val Tyr Gly Asn 
            20                  25                  30          


Lys Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Phe Ala Arg Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Gly 
                85                  90                  95      


Thr Asn Trp Tyr Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc agtccagtca aagagtttat ggtaacaaaa atttagcctg gtatcagcag      120

aaaccaggga aagcccctaa gctcctgatc tattttgcaa gaactctggc atctggggtc      180

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      240

caacctgaag attttgcaac ttactactgt caaggcactt attatggtac taattggtat      300

gttggtttcg gcggcgggac caaggtggag atcaaacgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgc         657


<210>  6
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt ctccctcgac acctatacaa tgatctgggt ccgccaggct      120

ccagggaagg gcctggagtg ggttggcatc atttatgtta cctataacac ttattatgcc      180

aactgggcga aaggcagatt caccatctca agagatgatt caaaaaacac gctgtatctg      240

caaatgaaca gcctgaaaac cgaggacaca gccgtgtatt actgtaccag atggggtgat      300

cagaatggac tggacatctg gggccagggc accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc gctagcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggacga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgccccccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggt                                                   1338


<210>  7
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly 
1               5                   10                  15      


Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr Leu Tyr Lys 
            20                  25                  30          


Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu 
        35                  40                  45              


Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val 
    50                  55                  60                  


Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr Leu Pro Leu 
65                  70                  75                  80  


Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe 
                85                  90                  95      


Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu 
            100                 105                 110         


Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser Gly Gly Val 
        115                 120                 125             


Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp 
    130                 135                 140                 


Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val Lys Asp Asn 
145                 150                 155                 160 


Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp 
                165                 170                 175     


Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala 
            180                 185                 190         


Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys 
        195                 200                 205             


His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys 
    210                 215                 220                 


Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys 
225                 230                 235                 240 


Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn 
                245                 250                 255     


Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro 
            260                 265                 270         


His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro 
        275                 280                 285             


Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys 
    290                 295                 300                 


Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg 
305                 310                 315                 320 


Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr 
                325                 330                 335     


Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp 
            340                 345                 350         


Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe 
        355                 360                 365             


Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro 
    370                 375                 380                 


Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly 
385                 390                 395                 400 


Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn 
                405                 410                 415     


Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala 
            420                 425                 430         


Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr His His Ser 
        435                 440                 445             


Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu Arg Leu Asp 
    450                 455                 460                 


Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly Lys Val 
465                 470                 475                 480 


Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly 
                485                 490                 495     


Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr 
            500                 505                 510         


His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala 
        515                 520                 525             


Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Gly Gly Thr Ala 
    530                 535                 540                 


Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe 
545                 550                 555                 560 


Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly 
                565                 570                 575     


Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg 
            580                 585                 590         


Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln 
        595                 600                 605             


Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr 
    610                 615                 620                 


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Ala Ala Ser Gly Phe Ser Leu Asp Thr Tyr Thr Met Ile 
1               5                   10              


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Ile Ile Tyr Val Thr Tyr Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Thr Arg Trp Gly Asp Gln Asn Gly Leu Asp Ile 
1               5                   10      


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Gln Ser Ser Gln Arg Val Tyr Gly Asn Lys Asn Leu Ala 
1               5                   10              


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Tyr Phe Ala Arg Thr Leu Ala Ser 
1               5               


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Gln Gly Thr Tyr Tyr Gly Thr Asn Trp Tyr Val Gly 
1               5                   10          


<210>  14
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt ctccctcgac acctatacaa tgatctgggt ccgccaggct      120

ccagggaagg gcctggagtg ggttggcatc atttatgtta cctataacac ttattatgcc      180

aactgggcga aaggcagatt caccatctca agagatgatt caaaaaacac gctgtatctg      240

caaatgaaca gcctgaaaac cgaggacaca gccgtgtatt actgtaccag atggggtgat      300

cagaatggac tggacatctg gggccagggc accctggtca ccgtctcctc a               351


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc agtccagtca aagagtttat ggtaacaaaa atttagcctg gtatcagcag      120

aaaccaggga aagcccctaa gctcctgatc tattttgcaa gaactctggc atctggggtc      180

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      240

caacctgaag attttgcaac ttactactgt caaggcactt attatggtac taattggtat      300

gttggtttcg gcggcgggac caaggtggag atcaaa                                336


<210>  16
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly Leu 
1               5                   10                  15      


Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr Leu Tyr Lys Leu 
            20                  25                  30          


Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu Thr 
        35                  40                  45              


Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val Thr 
    50                  55                  60                  


Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr Leu Pro Leu Pro 
65                  70                  75                  80  


Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe Ala 
                85                  90                  95      


Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu Arg 
            100                 105                 110         


Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser Gly Gly Val Tyr 
        115                 120                 125             


Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp Arg 
    130                 135                 140                 


Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val Lys Asp Asn Gly 
145                 150                 155                 160 


Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp Gly 
                165                 170                 175     


Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala Pro 
            180                 185                 190         


Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys His 
        195                 200                 205             


Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys Phe 
    210                 215                 220                 


Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys Pro 
225                 230                 235                 240 


Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn Pro 
                245                 250                 255     


His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro His 
            260                 265                 270         


Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro Asp 
        275                 280                 285             


Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys Gly 
    290                 295                 300                 


Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg Phe 
305                 310                 315                 320 


Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr Lys 
                325                 330                 335     


Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp Pro 
            340                 345                 350         


Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe Arg 
        355                 360                 365             


Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro Pro 
    370                 375                 380                 


His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly Gly 
385                 390                 395                 400 


Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn Leu 
                405                 410                 415     


Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala Gly 
            420                 425                 430         


Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr His His Ser Leu 
        435                 440                 445             


Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu Arg Leu Asp Ile 
    450                 455                 460                 


Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly Lys Val Cys 
465                 470                 475                 480 


Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly Gln 
                485                 490                 495     


Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr His 
            500                 505                 510         


Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala Glu 
        515                 520                 525             


Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ala Thr 
    530                 535                 540                 


Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe Arg 
545                 550                 555                 560 


Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly Ala 
                565                 570                 575     


Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg Pro 
            580                 585                 590         


Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln Asp 
        595                 600                 605             


Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr Met 
    610                 615                 620                 


Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe Met Met Leu Gly 
625                 630                 635                 640 


Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln Asn Lys Arg Ala 
                645                 650                 655     


Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu Pro Leu Asp Pro 
            660                 665                 670         


Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe Lys Glu Thr Glu 
        675                 680                 685             


Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe Gly Thr Val His 
    690                 695                 700                 


Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys Ile Pro Val Cys 
705                 710                 715                 720 


Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser Phe Gln Ala Val 
                725                 730                 735     


Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His Ala His Ile Val 
            740                 745                 750         


Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln Leu Val Thr Gln 
        755                 760                 765             


Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg Gln His Arg Gly 
    770                 775                 780                 


Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile Ala Lys 
785                 790                 795                 800 


Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His Arg Asn Leu Ala 
                805                 810                 815     


Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val Gln Val Ala Asp 
            820                 825                 830         


Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys Gln Leu Leu Tyr 
        835                 840                 845             


Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser Ile His 
    850                 855                 860                 


Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
865                 870                 875                 880 


Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu Arg 
                885                 890                 895     


Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Ala Gln 
            900                 905                 910         


Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp 
        915                 920                 925             


Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn Glu 
    930                 935                 940                 


Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile Lys Arg 
945                 950                 955                 960 


Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro His Gly Leu Thr 
                965                 970                 975     


Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu Leu Asp Leu Asp 
            980                 985                 990         


Leu Asp Leu Glu Ala Glu Glu Asp  Asn Leu Ala Thr Thr  Thr Leu Gly 
        995                 1000                 1005             


Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu Asn Arg  Pro Arg Gly 
    1010                 1015                 1020             


Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly Tyr Met  Pro Met Asn 
    1025                 1030                 1035             


Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu Ser Ala  Val Ser Gly 
    1040                 1045                 1050             


Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser Leu His  Pro Met Pro 
    1055                 1060                 1065             


Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu Gly His  Val Thr Gly 
    1070                 1075                 1080             


Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser Met Cys  Arg Ser Arg 
    1085                 1090                 1095             


Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly Asp Ser  Ala Tyr His 
    1100                 1105                 1110             


Ser Gln  Arg His Ser Leu Leu  Thr Pro Val Thr Pro  Leu Ser Pro 
    1115                 1120                 1125             


Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly Tyr Val  Met Pro Asp 
    1130                 1135                 1140             


Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg Glu Gly  Thr Leu Ser 
    1145                 1150                 1155             


Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr Glu Glu  Glu Asp Glu 
    1160                 1165                 1170             


Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg Arg Arg  His Ser Pro 
    1175                 1180                 1185             


Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu Glu Leu  Gly Tyr Glu 
    1190                 1195                 1200             


Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala Ser Leu  Gly Ser Thr 
    1205                 1210                 1215             


Gln Ser  Cys Pro Leu His Pro  Val Pro Ile Met Pro  Thr Ala Gly 
    1220                 1225                 1230             


Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met Asn Arg  Gln Arg Asp 
    1235                 1240                 1245             


Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala Met Gly  Ala Cys Pro 
    1250                 1255                 1260             


Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg Ala Phe  Gln Gly Pro 
    1265                 1270                 1275             


Gly His  Gln Ala Pro His Val  His Tyr Ala Arg Leu  Lys Thr Leu 
    1280                 1285                 1290             


Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe Asp Asn  Pro Asp Tyr 
    1295                 1300                 1305             


Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn Ala Gln  Arg Thr 
    1310                 1315                 1320         


<210>  17
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp Gly Pro Gly 
1               5                   10                  15      


Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala Pro Gln Cys 
            20                  25                  30          


Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys His Asp Glu 
        35                  40                  45              


Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys Phe Ala Cys 
    50                  55                  60                  


Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys Pro Gln Pro 
65                  70                  75                  80  


Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn Pro His Thr 
                85                  90                  95      


Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro His Asn Phe 
            100                 105                 110         


Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro Asp Lys Met 
        115                 120                 125             


Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys Gly Gly Leu 
    130                 135                 140                 


Cys Pro Lys 
145         


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Phe Gly Pro Asn 
1               5   


<210>  19
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Asn Trp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ala Lys Ala Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Leu Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  21
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr 
            


<210>  22
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Met Gly Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Asp Ile Gln His Ser Gly Gly Arg Ser Ser Leu Glu Gly 
                645                 650                 655     


Pro Arg Phe Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Met His 
            660                 665                 670         


Thr Gly His His His His His His 
        675                 680 


<210>  23
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly 
1               5                   10                  15      


Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr Leu Tyr Lys 
            20                  25                  30          


Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu 
        35                  40                  45              


Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val 
    50                  55                  60                  


Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr Leu Pro Leu 
65                  70                  75                  80  


Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe 
                85                  90                  95      


Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu 
            100                 105                 110         


Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser Gly Gly Val 
        115                 120                 125             


Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp 
    130                 135                 140                 


Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val Lys Asp Asn 
145                 150                 155                 160 


Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp 
                165                 170                 175     


Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala 
            180                 185                 190         


Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys 
        195                 200                 205             


His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys 
    210                 215                 220                 


Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys 
225                 230                 235                 240 


Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn 
                245                 250                 255     


Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro 
            260                 265                 270         


His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro 
        275                 280                 285             


Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys 
    290                 295                 300                 


Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg 
305                 310                 315                 320 


Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr 
                325                 330                 335     


Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp 
            340                 345                 350         


Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe 
        355                 360                 365             


Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro 
    370                 375                 380                 


Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly 
385                 390                 395                 400 


Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn 
                405                 410                 415     


Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala 
            420                 425                 430         


Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr His His Ser 
        435                 440                 445             


Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu Arg Leu Asp 
    450                 455                 460                 


Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly Lys Val 
465                 470                 475                 480 


Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly 
                485                 490                 495     


Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr 
            500                 505                 510         


His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala 
        515                 520                 525             


Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ala 
    530                 535                 540                 


Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe 
545                 550                 555                 560 


Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly 
                565                 570                 575     


Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg 
            580                 585                 590         


Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln 
        595                 600                 605             


Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr 
    610                 615                 620                 


Asp Ile Gln His Ser Gly Gly Arg Ser Ser Leu Glu Gly Pro Arg Phe 
625                 630                 635                 640 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Met His Thr Gly His 
                645                 650                 655     


His His His His His 
            660     


<210>  24
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Ser Glu Met Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly 
1               5                   10                  15      


Leu Ser Val Thr Gly Asp Ala Asp Asn Gln Tyr Gln Thr Leu Tyr Lys 
            20                  25                  30          


Leu Tyr Glu Lys Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu 
        35                  40                  45              


Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val 
    50                  55                  60                  


Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Val Leu Pro Leu 
65                  70                  75                  80  


Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe 
                85                  90                  95      


Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu 
            100                 105                 110         


Arg Gln Leu Arg Phe Thr Gln Leu Thr Glu Ile Leu Leu Gly Gly Val 
        115                 120                 125             


Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp 
    130                 135                 140                 


Arg Asp Ile Val Arg Val Pro Asp Ala Glu Ile Val Val Lys Asn Asn 
145                 150                 155                 160 


Gly Gly Asn Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp 
                165                 170                 175     


Gly Pro Gly Pro Glu Asp Cys Gln Ile Leu Thr Lys Thr Ile Cys Ala 
            180                 185                 190         


Pro Gln Cys Asn Gly Arg Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys 
        195                 200                 205             


His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys 
    210                 215                 220                 


Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys 
225                 230                 235                 240 


Pro Ala Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn 
                245                 250                 255     


Pro His Ile Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro 
            260                 265                 270         


His Asn Phe Val Val Asp Gln Thr Phe Cys Val Arg Ala Cys Pro Ala 
        275                 280                 285             


Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys 
    290                 295                 300                 


Arg Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg 
305                 310                 315                 320 


Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr 
                325                 330                 335     


Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp 
            340                 345                 350         


Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe 
        355                 360                 365             


Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro 
    370                 375                 380                 


Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly 
385                 390                 395                 400 


Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn 
                405                 410                 415     


Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala 
            420                 425                 430         


Gly Arg Val Tyr Ile Ser Ala Asn Gln Gln Leu Cys Tyr His His Ser 
        435                 440                 445             


Leu Asn Trp Thr Arg Leu Leu Arg Gly Pro Ala Glu Glu Arg Leu Asp 
    450                 455                 460                 


Ile Lys Tyr Asn Arg Pro Leu Gly Glu Cys Val Ala Glu Gly Lys Val 
465                 470                 475                 480 


Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly 
                485                 490                 495     


Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Glu Gly Val Cys Val Thr 
            500                 505                 510         


His Cys Asn Val Leu Gln Gly Glu Pro Arg Glu Phe Val His Glu Ala 
        515                 520                 525             


His Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ser 
    530                 535                 540                 


Thr Cys Asn Gly Ser Gly Ser Asp Ala Cys Ala Arg Cys Ala His Phe 
545                 550                 555                 560 


Arg Asp Gly Pro His Cys Val Asn Ser Cys Pro His Gly Ile Leu Gly 
                565                 570                 575     


Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Ala Gln Asn Glu Cys Arg 
            580                 585                 590         


Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln 
        595                 600                 605             


Asp Cys Leu Gly Gln Ala Glu Val Leu Met Ser Lys Pro His Leu Val 
    610                 615                 620                 


His His His His His His 
625                 630 


