                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       KARLISH, Steven J.D.
       KATZ, Adriana
       TAL, Daniel  M.
 
<120>  Selective inhibitors of alpha2-containing isoforms
       of Na,K-AtPase and use thereof for reduction of intraocular pressure

<130>  62818

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1023
<212>  PRT
<213>  homo sapiens

<400>  1

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  2
<211>  1020
<212>  PRT
<213>  homo sapiens

<400>  2

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  3
<211>  1013
<212>  PRT
<213>  homo sapiens

<400>  3

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
225                 230                 235                 240 


Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                245                 250                 255     


Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                325                 330                 335     


Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
        355                 360                 365             


Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
        595                 600                 605             


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Thr Tyr Tyr 
    1010             


<210>  4
<211>  1029
<212>  PRT
<213>  homo sapiens

<400>  4

Met Gly Leu Trp Gly Lys Lys Gly Thr Val Ala Pro His Asp Gln Ser 
1               5                   10                  15      


Pro Arg Arg Arg Pro Lys Lys Gly Leu Ile Lys Lys Lys Met Val Lys 
            20                  25                  30          


Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys Glu Val Val 
        35                  40                  45              


Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr Lys Tyr Ser 
    50                  55                  60                  


Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys Glu Ile Leu 
65                  70                  75                  80  


Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr Thr Pro Glu 
                85                  90                  95      


Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile Gln Ile Tyr 
        115                 120                 125             


Phe Asn Glu Glu Pro Thr Lys Asp Asn Leu Tyr Leu Ser Ile Val Leu 
    130                 135                 140                 


Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
145                 150                 155                 160 


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
                165                 170                 175     


Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn Val Gln Glu 
            180                 185                 190         


Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
        195                 200                 205             


Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val Asp Asn Ser 
    210                 215                 220                 


Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro Asp Phe Thr 
225                 230                 235                 240 


His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn 
                245                 250                 255     


Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Ser 
            260                 265                 270         


Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu Ala Val Gly 
        275                 280                 285             


Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Leu Ile Thr 
    290                 295                 300                 


Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile Gly Ile Ile 
                325                 330                 335     


Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu 
            340                 345                 350         


Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn 
        355                 360                 365             


Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp 
385                 390                 395                 400 


Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu Gln Thr Gly 
                405                 410                 415     


Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu Ala Arg Ile 
            420                 425                 430         


Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln Glu Ile Leu 
        435                 440                 445             


Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu Ser Ala Leu 
    450                 455                 460                 


Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu Met Arg Glu 
465                 470                 475                 480 


Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr 
                485                 490                 495     


Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr His Val Leu 
            500                 505                 510         


Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys Ser Thr Phe 
        515                 520                 525             


Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met Lys Glu Ala 
    530                 535                 540                 


Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu 
545                 550                 555                 560 


Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys Gly Phe Pro 
                565                 570                 575     


Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu Cys Phe Val 
            580                 585                 590         


Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
        595                 600                 605             


Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
    610                 615                 620                 


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
625                 630                 635                 640 


Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg Leu Lys Ile 
                645                 650                 655     


Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile Val Val His 
            660                 665                 670         


Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp Gln Ile Leu 
        675                 680                 685             


Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
    690                 695                 700                 


Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val Val Ala Val 
705                 710                 715                 720 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
                725                 730                 735     


Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala Ala 
            740                 745                 750         


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
        755                 760                 765             


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Met Tyr 
    770                 775                 780                 


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Met Phe Ile 
785                 790                 795                 800 


Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
                805                 810                 815     


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ser 
            820                 825                 830         


Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro Lys Thr Asp 
        835                 840                 845             


Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly Gln Ile Gly 
    850                 855                 860                 


Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
                885                 890                 895     


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
            900                 905                 910         


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
        915                 920                 925             


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
    930                 935                 940                 


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
945                 950                 955                 960 


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
                965                 970                 975     


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
            980                 985                 990         


Trp Trp Leu Cys Ala Ile Pro Tyr  Ser Ile Leu Ile Phe  Val Tyr Asp 
        995                 1000                 1005             


Glu Ile  Arg Lys Leu Leu Ile  Arg Gln His Pro Asp  Gly Trp Val 
    1010                 1015                 1020             


Glu Arg  Glu Thr Tyr Tyr 
    1025                 


<210>  5
<211>  303
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
1               5                   10                  15      


Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
            20                  25                  30          


Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
        35                  40                  45              


Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
    50                  55                  60                  


Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
65                  70                  75                  80  


Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                85                  90                  95      


Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
            100                 105                 110         


Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
        115                 120                 125             


Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
    130                 135                 140                 


Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
145                 150                 155                 160 


Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                165                 170                 175     


Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
            180                 185                 190         


Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
        195                 200                 205             


Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
    210                 215                 220                 


Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
225                 230                 235                 240 


Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
            260                 265                 270         


Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
        275                 280                 285             


Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
    290                 295                 300             


<210>  6
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence encoding  His10-ATP1B1

<400>  6

Met Ala Arg Ser His His His His His His His His His His Pro Arg 
1               5                   10                  15      


Arg Ser Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
            20                  25                  30          


Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
        35                  40                  45              


Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
    50                  55                  60                  


Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
65                  70                  75                  80  


Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
                85                  90                  95      


Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
            100                 105                 110         


Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
        115                 120                 125             


Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
    130                 135                 140                 


Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
145                 150                 155                 160 


Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
                165                 170                 175     


Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
            180                 185                 190         


Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
        195                 200                 205             


Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
    210                 215                 220                 


Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
225                 230                 235                 240 


Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
                245                 250                 255     


Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
            260                 265                 270         


Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
        275                 280                 285             


Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
    290                 295                 300                 


Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
305                 310                 315                 


<210>  7
<211>  290
<212>  PRT
<213>  homo sapiens

<400>  7

Met Val Ile Gln Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu 
1               5                   10                  15      


Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg 
            20                  25                  30          


Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
        35                  40                  45              


Gly Phe Leu Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln 
    50                  55                  60                  


Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro 
65                  70                  75                  80  


Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn 
                85                  90                  95      


Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys 
            100                 105                 110         


Phe Leu Glu Pro Tyr Asn Asp Ser Ile Gln Ala Gln Lys Asn Asp Val 
        115                 120                 125             


Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn 
    130                 135                 140                 


Tyr Pro Lys Arg Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys 
145                 150                 155                 160 


Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro 
                165                 170                 175     


Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala 
            180                 185                 190         


Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala 
        195                 200                 205             


Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp 
    210                 215                 220                 


Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr 
225                 230                 235                 240 


Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu 
                245                 250                 255     


Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp 
            260                 265                 270         


Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn 
        275                 280                 285             


Lys Thr 
    290 


<210>  8
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence encoding  His10-ATP1B2

<400>  8

Met Ala Arg Ser His His His His His His His His His His Pro Arg 
1               5                   10                  15      


Arg Ser Arg Gly Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu 
            20                  25                  30          


Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg 
        35                  40                  45              


Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
    50                  55                  60                  


Gly Phe Leu Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln 
65                  70                  75                  80  


Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro 
                85                  90                  95      


Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn 
            100                 105                 110         


Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys 
        115                 120                 125             


Phe Leu Glu Pro Tyr Asn Asp Ser Ile Gln Ala Gln Lys Asn Asp Val 
    130                 135                 140                 


Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn 
145                 150                 155                 160 


Tyr Pro Lys Arg Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys 
                165                 170                 175     


Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro 
            180                 185                 190         


Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala 
        195                 200                 205             


Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala 
    210                 215                 220                 


Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp 
225                 230                 235                 240 


Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr 
                245                 250                 255     


Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu 
            260                 265                 270         


Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp 
        275                 280                 285             


Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn 
    290                 295                 300                 


Lys Thr 
305     


<210>  9
<211>  279
<212>  PRT
<213>  homo sapiens

<400>  9

Met Thr Lys Asn Glu Lys Lys Ser Leu Asn Gln Ser Leu Ala Glu Trp 
1               5                   10                  15      


Lys Leu Phe Ile Tyr Asn Pro Thr Thr Gly Glu Phe Leu Gly Arg Thr 
            20                  25                  30          


Ala Lys Ser Trp Gly Leu Ile Leu Leu Phe Tyr Leu Val Phe Tyr Gly 
        35                  40                  45              


Phe Leu Ala Ala Leu Phe Ser Phe Thr Met Trp Val Met Leu Gln Thr 
    50                  55                  60                  


Leu Asn Asp Glu Val Pro Lys Tyr Arg Asp Gln Ile Pro Ser Pro Gly 
65                  70                  75                  80  


Leu Met Val Phe Pro Lys Pro Val Thr Ala Leu Glu Tyr Thr Phe Ser 
                85                  90                  95      


Arg Ser Asp Pro Thr Ser Tyr Ala Gly Tyr Ile Glu Asp Leu Lys Lys 
            100                 105                 110         


Phe Leu Lys Pro Tyr Thr Leu Glu Glu Gln Lys Asn Leu Thr Val Cys 
        115                 120                 125             


Pro Asp Gly Ala Leu Phe Glu Gln Lys Gly Pro Val Tyr Val Ala Cys 
    130                 135                 140                 


Gln Phe Pro Ile Ser Leu Leu Gln Ala Cys Ser Gly Met Asn Asp Pro 
145                 150                 155                 160 


Asp Phe Gly Tyr Ser Gln Gly Asn Pro Cys Ile Leu Val Lys Met Asn 
                165                 170                 175     


Arg Ile Ile Gly Leu Lys Pro Glu Gly Val Pro Arg Ile Asp Cys Val 
            180                 185                 190         


Ser Lys Asn Glu Asp Ile Pro Asn Val Ala Val Tyr Pro His Asn Gly 
        195                 200                 205             


Met Ile Asp Leu Lys Tyr Phe Pro Tyr Tyr Gly Lys Lys Leu His Val 
    210                 215                 220                 


Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser Phe Ala Pro Asn 
225                 230                 235                 240 


Asn Thr Gly Lys Glu Val Thr Val Glu Cys Lys Ile Asp Gly Ser Ala 
                245                 250                 255     


Asn Leu Lys Ser Gln Asp Asp Arg Asp Lys Phe Leu Gly Arg Val Met 
            260                 265                 270         


Phe Lys Ile Thr Ala Arg Ala 
        275                 


<210>  10
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence encoding  His10-ATP1B3

<400>  10

Met Ala Arg Ser His His His His His His His His His His Pro Arg 
1               5                   10                  15      


Arg Ser Arg Gly Asn Glu Lys Lys Ser Leu Asn Gln Ser Leu Ala Glu 
            20                  25                  30          


Trp Lys Leu Phe Ile Tyr Asn Pro Thr Thr Gly Glu Phe Leu Gly Arg 
        35                  40                  45              


Thr Ala Lys Ser Trp Gly Leu Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
    50                  55                  60                  


Gly Phe Leu Ala Ala Leu Phe Ser Phe Thr Met Trp Val Met Leu Gln 
65                  70                  75                  80  


Thr Leu Asn Asp Glu Val Pro Lys Tyr Arg Asp Gln Ile Pro Ser Pro 
                85                  90                  95      


Gly Leu Met Val Phe Pro Lys Pro Val Thr Ala Leu Glu Tyr Thr Phe 
            100                 105                 110         


Ser Arg Ser Asp Pro Thr Ser Tyr Ala Gly Tyr Ile Glu Asp Leu Lys 
        115                 120                 125             


Lys Phe Leu Lys Pro Tyr Thr Leu Glu Glu Gln Lys Asn Leu Thr Val 
    130                 135                 140                 


Cys Pro Asp Gly Ala Leu Phe Glu Gln Lys Gly Pro Val Tyr Val Ala 
145                 150                 155                 160 


Cys Gln Phe Pro Ile Ser Leu Leu Gln Ala Cys Ser Gly Met Asn Asp 
                165                 170                 175     


Pro Asp Phe Gly Tyr Ser Gln Gly Asn Pro Cys Ile Leu Val Lys Met 
            180                 185                 190         


Asn Arg Ile Ile Gly Leu Lys Pro Glu Gly Val Pro Arg Ile Asp Cys 
        195                 200                 205             


Val Ser Lys Asn Glu Asp Ile Pro Asn Val Ala Val Tyr Pro His Asn 
    210                 215                 220                 


Gly Met Ile Asp Leu Lys Tyr Phe Pro Tyr Tyr Gly Lys Lys Leu His 
225                 230                 235                 240 


Val Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser Phe Ala Pro 
                245                 250                 255     


Asn Asn Thr Gly Lys Glu Val Thr Val Glu Cys Lys Ile Asp Gly Ser 
            260                 265                 270         


Ala Asn Leu Lys Ser Gln Asp Asp Arg Asp Lys Phe Leu Gly Arg Val 
        275                 280                 285             


Met Phe Lys Ile Thr Ala Arg Ala 
    290                 295     


<210>  11
<211>  3072
<212>  DNA
<213>  homo sapiens

<400>  11
atggggaagg gggttggacg tgataagtat gagcctgcag ctgtttcaga acaaggtgat       60

aaaaagggca aaaagggcaa aaaagacagg gacatggatg aactgaagaa agaagtttct      120

atggatgatc ataaacttag ccttgatgaa cttcatcgta aatatggaac agacttgagc      180

cggggattaa catctgctcg tgcagctgag atcctggcgc gagatggtcc caacgccctc      240

actccccctc ccactactcc tgaatggatc aagttttgtc ggcagctctt tggggggttc      300

tcaatgttac tgtggattgg agcgattctt tgtttcttgg cttatagcat ccaagctgct      360

acagaagagg aacctcaaaa cgataatctg tacctgggtg tggtgctatc agccgttgta      420

atcataactg gttgcttctc ctactatcaa gaagctaaaa gttcaaagat catggaatcc      480

ttcaaaaaca tggtccctca gcaagccctt gtgattcgaa atggtgagaa aatgagcata      540

aatgcggagg aagttgtggt tggggatctg gtggaagtaa aaggaggaga ccgaattcct      600

gctgacctca gaatcatatc tgcaaatggc tgcaaggtgg ataactcctc gctcactggt      660

gaatcagaac cccagactag gtctccagat ttcacaaatg aaaaccccct ggagacgagg      720

aacattgcct tcttttcaac aaattgtgtt gaaggcaccg cacgtggtat tgttgtctac      780

actggggatc gcactgtgat gggaagaatt gccacacttg cttctgggct ggaaggaggc      840

cagaccccca ttgctgcaga aattgaacat tttatccaca tcatcacggg tgtggctgtg      900

ttcctgggtg tgtctttctt catcctttct ctcatccttg agtacacctg gcttgaggct      960

gtcatcttcc tcatcggtat catcgtagcc aatgtgccgg aaggtttgct ggccactgtc     1020

acggtctgtc tgacacttac tgccaaacgc atggcaagga aaaactgctt agtgaagaac     1080

ttagaagctg tggagacctt ggggtccacg tccaccatct gctctgataa aactggaact     1140

ctgactcaga accggatgac agtggcccac atgtggtttg acaatcaaat ccatgaagct     1200

gatacgacag agaatcagag tggtgtctct tttgacaaga cttcagctac ctggcttgct     1260

ctgtccagaa ttgcaggtct ttgtaacagg gcagtgtttc aggctaacca ggaaaaccta     1320

cctattctta agcgggcagt tgcaggagat gcctctgagt cagcactctt aaagtgcata     1380

gagctgtgct gtggttccgt gaaggagatg agagaaagat acgccaaaat cgtcgagata     1440

cccttcaact ccaccaacaa gtaccagttg tctattcata agaaccccaa cacatcggag     1500

ccccaacacc tgttggtgat gaagggcgcc ccagaaagga tcctagaccg ttgcagctct     1560

atcctcctcc acggcaagga gcagcccctg gatgaggagc tgaaagacgc ctttcagaac     1620

gcctatttgg agctgggggg cctcggagaa cgagtcctag gtttctgcca cctctttctg     1680

ccagatgaac agtttcctga agggttccag tttgacactg acgatgtgaa tttccctatc     1740

gataatctgt gctttgttgg gctcatctcc atgattgacc ctccacgggc ggccgttcct     1800

gatgccgtgg gcaaatgtcg aagtgctgga attaaggtca tcatggtcac aggagaccat     1860

ccaatcacag ctaaagctat tgccaaaggt gtgggcatca tctcagaagg caatgagacc     1920

gtggaagaca ttgctgcccg cctcaacatc ccagtcagcc aggtgaaccc cagggatgcc     1980

aaggcctgcg tagtacacgg cagtgatcta aaggacatga cctccgagca gctggatgac     2040

attttgaagt accacactga gatagtgttt gccaggacct cccctcagca gaagctcatc     2100

attgtggaag gctgccaaag acagggtgct atcgtggctg tgactggtga cggtgtgaat     2160

gactctccag ctttgaagaa agcagacatt ggggttgcta tggggattgc tggctcagat     2220

gtgtccaagc aagctgctga catgattctt ctggatgaca actttgcctc aattgtgact     2280

ggagtagagg aaggtcgtct gatctttgat aacttgaaga aatccattgc ttatacctta     2340

accagtaaca ttcccgagat caccccgttc ctgatattta ttattgcaaa cattccacta     2400

ccactgggga ctgtcaccat cctctgcatt gacttgggca ctgacatggt tcctgccatc     2460

tccctggctt atgagcaggc tgagagtgac atcatgaaga gacagcccag aaatcccaaa     2520

acagacaaac ttgtgaatga gcggctgatc agcatggcct atgggcagat tggaatgatc     2580

caggccctgg gaggcttctt tacttacttt gtgattctgg ctgagaacgg cttcctccca     2640

attcacctgt tgggcctccg agtggactgg gatgaccgct ggatcaacga tgtggaagac     2700

agctacgggc agcagtggac ctatgagcag aggaaaatcg tggagttcac ctgccacaca     2760

gccttcttcg tcagtatcgt ggtggtgcag tgggccgact tggtcatctg taagaccagg     2820

aggaattcgg tcttccagca ggggatgaag aacaagatct tgatatttgg cctctttgaa     2880

gagacagccc tggctgcttt cctttcctac tgccctggaa tgggtgttgc tcttaggatg     2940

tatcccctca aacctacctg gtggttctgt gccttcccct actctcttct catcttcgta     3000

tatgacgaag tcagaaaact catcatcagg cgacgccctg gcggctgggt ggagaaggaa     3060

acctactatt ag                                                         3072


<210>  12
<211>  3063
<212>  DNA
<213>  homo sapiens

<400>  12
atgggccgtg gggctggccg tgagtactca cctgccgcca ccacggcaga gaatgggggc       60

ggcaagaaga aacagaagga gaaggaactg gatgagctga agaaggaggt ggcaatggat      120

gaccacaagc tgtccttgga tgagctgggc cgcaaatacc aagtggacct gtccaagggc      180

ctcaccaacc agcgggctca ggacgttctg gctcgagatg ggcccaacgc cctcacacca      240

cctcccacaa cccctgagtg ggtcaagttc tgccgtcagc ttttcggggg gttctccatc      300

ctgctgtgga ttggggctat cctctgcttc ctggcctacg gcatccaggc tgccatggag      360

gatgaaccat ccaacgacaa tctatatctg ggtgtggtgc tggcagctgt ggtcattgtc      420

actggctgct tctcctacta ccaggaggcc aagagctcca agatcatgga ttccttcaag      480

aacatggtac ctcagcaagc ccttgtgatc cgggagggag agaagatgca gatcaacgca      540

gaggaagtgg tggtgggaga cctggtggag gtgaagggtg gagaccgcgt ccctgctgac      600

ctccggatca tctcttctca tggctgtaag gtggataact catccttaac aggagagtcg      660

gagccccaga cccgctcccc cgagttcacc catgagaacc ccctggagac ccgcaatatc      720

tgtttcttct ccaccaactg tgttgaaggc actgccaggg gcattgtgat tgccacagga      780

gaccggacgg tgatgggccg catagctact ctcgcctcag gcctggaggt tgggcggaca      840

cccatagcaa tggagattga acacttcatc cagctgatca caggggtcgc tgtattcctg      900

ggggtctcct tcttcgtgct ctccctcatc ctgggctaca gctggctgga ggcagtcatc      960

ttcctcatcg gcatcatagt ggccaacgtg cctgaggggc ttctggccac tgtcactgtg     1020

tgcctgaccc tgacagccaa gcgcatggca cggaagaact gcctggtgaa gaacctggag     1080

gcggtggaga cgctgggctc cacgtccacc atctgctcgg acaagacggg caccctcacc     1140

cagaaccgca tgaccgtcgc ccacatgtgg ttcgacaacc aaatccatga ggctgacacc     1200

accgaagatc agtctggggc cacttttgac aaacgatccc ctacgtggac ggccctgtct     1260

cgaattgctg gtctctgcaa ccgcgccgtc ttcaaggcag gacaggagaa catctccgtg     1320

tctaagcggg acacagctgg tgatgcctct gagtcagctc tgctcaagtg cattgagctc     1380

tcctgtggct cagtgaggaa aatgagagac agaaacccca aggtggcaga gattcctttc     1440

aactctacca acaagtacca gctgtctatc cacgagcgag aagacagccc ccagagccac     1500

gtgctggtga tgaagggggc cccagagcgc attctggacc ggtgctccac catcctggtg     1560

cagggcaagg agatcccgct cgacaaggag atgcaagatg cctttcaaaa tgcctacatg     1620

gagctggggg gacttgggga gcgtgtgctg ggattctgtc aactgaatct gccatctgga     1680

aagtttcctc ggggcttcaa attcgacacg gatgagctga actttcccac ggagaagctt     1740

tgctttgtgg ggctcatgtc tatgattgac cctccccggg ctgctgtgcc agatgctgtg     1800

ggcaagtgcc gaagcgcagg catcaaggtg atcatggtaa ccggggatca ccctatcaca     1860

gccaaggcca ttgccaaagg cgtgggcatc atatcagagg gtaacgagac tgtggaggac     1920

attgcagccc ggctcaacat tcccatgagt caagtcaacc ccagagaagc caaggcatgc     1980

gtggtgcacg gctctgacct gaaggacatg acatcggagc agctcgatga gatcctcaag     2040

aaccacacag agatcgtctt tgctcgaacg tctccccagc agaagctcat cattgtggag     2100

ggatgtcaga ggcagggagc cattgtggcc gtgacgggtg acggggtgaa cgactcccct     2160

gcattgaaga aggctgacat tggcattgcc atgggcatct ctggctctga cgtctctaag     2220

caggcagccg acatgatcct gctggatgac aactttgcct ccatcgtcac gggggtggag     2280

gagggccgcc tgatctttga caacttgaag aaatccatcg cctacaccct gaccagcaac     2340

atccccgaga tcaccccctt cctgctgttc atcattgcca acatccccct acctctgggc     2400

actgtgacca tcctttgcat tgacctgggc acagatatgg tccctgccat ctccttggcc     2460

tatgaggcag ctgagagtga tatcatgaag cggcagccac gaaactccca gacggacaag     2520

ctggtgaatg agaggctcat cagcatggcc tacggacaga tcgggatgat ccaggcactg     2580

ggtggcttct tcacctactt tgtgatcctg gcagagaacg gtttcctgcc atcacggcta     2640

ctgggaatcc gcctcgactg ggatgaccgg accatgaatg atctggagga cagctatgga     2700

caggagtgga cctatgagca gcggaaggtg gtggagttca cgtgccacac ggcattcttt     2760

gccagcatcg tggtggtgca gtgggctgac ctcatcatct gcaagacccg ccgcaactca     2820

gtcttccagc agggcatgaa gaacaagatc ctgatttttg ggctcctgga ggagacggcg     2880

ttggctgcct ttctctctta ctgcccaggc atgggtgtag ccctccgcat gtacccgctc     2940

aaagtcacct ggtggttctg cgccttcccc tacagcctcc tcatcttcat ctatgatgag     3000

gtccgaaagc tcatcctgcg gcggtatcct ggtggctggg tggagaagga gacatactac     3060

tga                                                                   3063


<210>  13
<211>  3042
<212>  DNA
<213>  homo sapiens

<400>  13
atgggggaca agaaagatga caaggactca cccaagaaga acaagggcaa ggagcgccgg       60

gacctggatg acctcaagaa ggaggtggct atgacagagc acaagatgtc agtggaagag      120

gtctgccgga aatacaacac agactgtgtg cagggtttga cccacagcaa agcccaggag      180

atcctggccc gggatgggcc taacgcactc acgccaccgc ctaccacccc agagtgggtc      240

aagttttgcc ggcagctctt cgggggcttc tccatcctgc tgtggatcgg ggctatcctc      300

tgcttcctgg cctacggtat ccaggcgggc accgaggacg acccctctgg tgacaacctg      360

tacctgggca tcgtgctggc ggccgtggtg atcatcactg gctgcttctc ctactaccag      420

gaggccaaga gctccaagat catggagtcc ttcaagaaca tggtgcccca gcaagccctg      480

gtgatccggg aaggtgagaa gatgcaggtg aacgctgagg aggtggtggt cggggacctg      540

gtggagatca agggtggaga ccgagtgcca gctgacctgc ggatcatctc agcccacggc      600

tgcaaggtgg acaactcctc cctgactggc gaatccgagc cccagactcg ctctcccgac      660

tgcacgcacg acaacccctt ggagactcgg aacatcacct tcttttccac caactgtgtg      720

gaaggcacgg ctcggggcgt ggtggtggcc acgggcgacc gcactgtcat gggccgtatc      780

gccaccctgg catcagggct ggaggtgggc aagacgccca tcgccatcga gattgagcac      840

ttcatccagc tcatcaccgg cgtggctgtc ttcctgggtg tctccttctt catcctctcc      900

ctcattctcg gatacacctg gcttgaggct gtcatcttcc tcatcggcat catcgtggcc      960

aatgtcccag agggtctgct ggccactgtc actgtgtgtc tgacgctgac cgccaagcgc     1020

atggcccgga agaactgcct ggtgaagaac ctggaggctg tagaaaccct gggctccacg     1080

tccaccatct gctcagataa gacagggacc ctcactcaga accgcatgac agtcgcccac     1140

atgtggtttg acaaccagat ccacgaggct gacaccactg aggaccagtc agggacctca     1200

tttgacaaga gttcgcacac ctgggtggcc ctgtctcaca tcgctgggct ctgcaatcgc     1260

gctgtcttca agggtggtca ggacaacatc cctgtgctca agagggatgt ggctggggat     1320

gcgtctgagt ctgccctgct caagtgcatc gagctgtcct ctggctccgt gaagctgatg     1380

cgtgaacgca acaagaaagt ggctgagatt cccttcaatt ccaccaacaa ataccagctc     1440

tccatccatg agaccgagga ccccaacgac aaccgatacc tgctggtgat gaagggtgcc     1500

cccgagcgca tcctggaccg ctgctccacc atcctgctac agggcaagga gcagcctctg     1560

gacgaggaaa tgaaggaggc cttccagaat gcctaccttg agctcggtgg cctgggcgag     1620

cgcgtgcttg gtttctgcca ttattacctg cccgaggagc agttccccaa gggctttgcc     1680

ttcgactgtg atgacgtgaa cttcaccacg gacaacctct gctttgtggg cctcatgtcc     1740

atgatcgacc caccccgggc agccgtccct gacgcggtgg gcaagtgtcg cagcgcaggc     1800

atcaaggtca tcatggtcac cggcgatcac cccatcacgg ccaaggccat tgccaagggt     1860

gtgggcatca tctctgaggg caacgagact gtggaggaca tcgccgcccg gctcaacatt     1920

cccgtcagcc aggttaaccc ccgggatgcc aaggcctgcg tgatccacgg caccgacctc     1980

aaggacttca cctccgagca aatcgacgag atcctgcaga atcacaccga gatcgtcttc     2040

gcccgcacat ccccccagca gaagctcatc attgtggagg gctgtcagag acagggtgca     2100

attgtggctg tgaccgggga tggtgtgaac gactcccccg ctctgaagaa ggccgacatt     2160

ggggtggcca tgggcatcgc tggctctgac gtctccaagc aggcagctga catgatcctg     2220

ctggacgaca actttgcctc catcgtcaca ggggtggagg agggccgcct gatcttcgac     2280

aacctaaaga agtccattgc ctacaccctg accagcaata tcccggagat cacgcccttc     2340

ctgctgttca tcatggccaa catcccgctg cccctgggca ccatcaccat cctctgcatc     2400

gatctgggca ctgacatggt ccctgccatc tcactggcgt acgaggctgc cgaaagcgac     2460

atcatgaaga gacagcccag gaacccgcgg acggacaaat tggtcaatga gagactcatc     2520

agcatggcct acgggcagat tggaatgatc caggctctcg gtggcttctt ctcttacttt     2580

gtgatcctgg cagaaaatgg cttcttgccc ggcaacctgg tgggcatccg gctgaactgg     2640

gatgaccgca ccgtcaatga cctggaagac agttacgggc agcagtggac atacgagcag     2700

aggaaggtgg tggagttcac ctgccacacg gccttctttg tgagcatcgt tgtcgtccag     2760

tgggccgatc tgatcatctg caagacccgg aggaactcgg tcttccagca gggcatgaag     2820

aacaagatcc tgatcttcgg gctgtttgag gagacggccc tggctgcctt cctgtcctac     2880

tgccccggca tggacgtggc cctgcgcatg taccctctca agcccagctg gtggttctgt     2940

gccttcccct acagtttcct catcttcgtc tacgacgaaa tccgcaaact catcctgcgc     3000

aggaacccag ggggttgggt ggagaaggaa acctactact ga                        3042


<210>  14
<211>  3090
<212>  DNA
<213>  homo sapiens

<400>  14
atggggcttt gggggaagaa agggacagtg gctccccatg accagagtcc aagacgaaga       60

cctaaaaaag ggcttatcaa gaaaaaaatg gtgaagaggg aaaaacagaa gcgcaatatg      120

gaggaactga agaaggaagt ggtcatggat gatcacaaat taaccttgga agagctgagc      180

accaagtact ccgtggacct gacaaagggc catagccacc aaagggcaaa ggaaatcctg      240

actcgaggtg gacccaatac tgttacccca ccccccacca ctccagaatg ggtcaaattc      300

tgtaagcaac tgttcggagg cttctccctc ctactatgga ctggggccat tctctgcttt      360

gtggcctaca gcatccagat atatttcaat gaggagccta ccaaagacaa cctctacctg      420

agcatcgtac tgtccgtcgt ggtcatcgtc actggctgct tctcctatta tcaggaggcc      480

aagagctcca agatcatgga gtcttttaag aacatggtgc ctcagcaagc tctggtaatt      540

cgaggaggag agaagatgca aattaatgta caagaggtgg tgttgggaga cctggtggaa      600

atcaagggtg gagaccgagt ccctgctgac ctccggctta tctctgcaca aggatgtaag      660

gtggacaact catccttgac tggggagtca gaaccccaga gccgctcccc tgacttcacc      720

catgagaacc ctctggagac ccgaaacatc tgcttctttt ccaccaactg tgtggaagga      780

accgcccggg gtattgtgat tgctacggga gactccacag tgatgggcag aattgcctcc      840

ctgacgtcag gcctggcggt tggccagaca cctatcgctg ctgagatcga acacttcatc      900

catctgatca ctgtggtggc cgtcttcctt ggtgtcactt tttttgcgct ctcacttctc      960

ttgggctatg gttggctgga ggctatcatt tttctcattg gcatcattgt ggccaatgtg     1020

cctgaggggc tgttggctac agtcactgtg tgcctgaccc tcacagccaa gcgcatggca     1080

cggaagaact gcctggtgaa gaacctggag gcggtggaga cgctgggctc cacgtccacc     1140

atctgctcag acaagacggg caccctcacc cagaaccgca tgaccgtcgc ccacatgtgg     1200

tttgatatga ccgtgtatga ggccgacacc actgaagaac agactggaaa aacatttacc     1260

aagagctctg atacctggtt tatgctggcc cgaatcgctg gcctctgcaa ccgggctgac     1320

tttaaggcta atcaggagat cctgcccatt gctaagaggg ccacaacagg tgatgcttcc     1380

gagtcagccc tcctcaagtt catcgagcag tcttacagct ctgtggcgga gatgagagag     1440

aaaaacccca aggtggcaga gattcccttt aattctacca acaagtacca gatgtccatc     1500

caccttcggg aggacagctc ccagacccac gtactgatga tgaagggtgc tccggagagg     1560

atcttggagt tttgttctac ctttcttctg aatgggcagg agtactcaat gaacgatgaa     1620

atgaaggaag ccttccaaaa tgcctattta gaactgggag gtctggggga acgtgtgcta     1680

ggcttctgct tcttgaatct gcctagcagc ttctccaagg gattcccatt taatacagat     1740

gaaataaatt tccccatgga caacctttgt tttgtgggcc tcatatccat gattgaccct     1800

ccccgagctg cagtgcctga tgctgtgagc aagtgtcgca gtgcaggaat taaggtgatc     1860

atggtaacag gagatcatcc cattacagct aaggccattg ccaagggtgt gggcatcatc     1920

tcagaaggca ctgagacggc agaggaagtc gctgcccggc ttaagatccc tatcagcaag     1980

gtcgatgcca gtgctgccaa agccattgtg gtgcatggtg cagaactgaa ggacatacag     2040

tccaagcagc ttgatcagat cctccagaac caccctgaga tcgtgtttgc tcggacctcc     2100

cctcagcaga agctcatcat tgtcgaggga tgtcagaggc tgggagccgt tgtggccgtg     2160

acaggtgacg gggtgaacga ctcccctgcg ctgaagaagg ctgacattgg cattgccatg     2220

ggcatctctg gctctgacgt ctctaagcag gcagccgaca tgatcctgct ggatgacaac     2280

tttgcctcca tcgtcacggg ggtggaggag ggccgcctga tctttgacaa cctgaagaaa     2340

tccatcatgt acaccctgac cagcaacatc cccgagatca cgcccttcct gatgttcatc     2400

atcctcggta tacccctgcc tctgggaacc ataaccatcc tctgcattga tctcggcact     2460

gacatggtcc ctgccatctc cttggcttat gagtcagctg aaagcgacat catgaagagg     2520

cttccaagga acccaaagac ggataatctg gtgaaccacc gtctcattgg catggcctat     2580

ggacagattg ggatgatcca ggctctggct ggattcttta cctactttgt aatcctggct     2640

gagaatggtt ttaggcctgt tgatctgctg ggcatccgcc tccactggga agataaatac     2700

ttgaatgacc tggaggacag ctacggacag cagtggacct atgagcaacg aaaagttgtg     2760

gagttcacat gccaaacggc cttttttgtc accatcgtgg ttgtgcagtg ggcggatctc     2820

atcatctcca agactcgccg caactcactt ttccagcagg gcatgagaaa caaagtctta     2880

atatttggga tcctggagga gacactcttg gctgcatttc tgtcctacac tccaggcatg     2940

gacgtggccc tgcgaatgta cccactcaag ataacctggt ggctctgtgc cattccctac     3000

agtattctca tcttcgtcta tgatgaaatc agaaaactcc tcatccgtca gcacccggat     3060

ggctgggtgg aaagggagac gtactactaa                                      3090


<210>  15
<211>  963
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence encoding  His10-ATP1B1

<400>  15
atggccagat cacatcatca ccatcaccac catcaccatc atcctaggag atctgcccgc       60

gggaaagcca aggaggaggg cagctggaag aaattcatct ggaactcaga gaagaaggag      120

tttctgggca ggaccggtgg cagttggttt aagatccttc tattctacgt aatattttat      180

ggctgcctgg ctggcatctt catcggaacc atccaagtga tgctgctcac catcagtgaa      240

tttaagccca catatcagga ccgagtggcc ccgccaggat taacacagat tcctcagatc      300

cagaagactg aaatttcctt tcgtcctaat gatcccaaga gctatgaggc atatgtactg      360

aacatagtta ggttcctgga aaagtacaaa gattcagccc agagggatga catgattttt      420

gaagattgtg gcgatgtgcc cagtgaaccg aaagaacgag gagactttaa tcatgaacga      480

ggagagcgaa aggtctgcag attcaagctt gaatggctgg gaaattgctc tggattaaat      540

gatgaaactt atggctacaa agagggcaaa ccgtgcatta ttataaagct caaccgagtt      600

ctaggcttca aacctaagcc tcccaagaat gagtccttgg agacttaccc agtgatgaag      660

tataacccaa atgtccttcc cgttcagtgc actggcaagc gagatgaaga taaggataaa      720

gttggaaatg tggagtattt tggactgggc aactcccctg gttttcctct gcagtattat      780

ccgtactatg gcaaactcct gcagcccaaa tacctgcagc ccctgctggc cgtacagttc      840

accaatctta ccatggacac tgaaattcgc atagagtgta aggcgtacgg tgagaacatt      900

gggtacagtg agaaagaccg ttttcaggga cgttttgatg taaaaattga agttaagagc      960

tga                                                                    963


<210>  16
<211>  924
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence encoding  His10-ATP1B2

<400>  16
atggccagat cacatcatca ccatcaccac catcaccatc atcctaggag atctgtcatc       60

cagaaagaga agaagagctg cgggcaggtg gttgaggagt ggaaggagtt cgtgtggaac      120

ccgaggacgc accagtttat gggccgcacc gggaccagct gggcctttat cctcctcttc      180

tacctcgttt tttatgggtt ccccaccgcc atgttcaccc tcaccatgtg ggtgatgctg      240

cagactgtct ccgaccatac ccccaagtac caggaccgac tggccacacc gggcttgatg      300

attcgcccca agactgagaa ccttgatgtc attgtcaatg tcagtgacac tgaaagctgg      360

gaccagcatg ttcagaagct caacaagttc ttggagcctt acaacgactc tatgcaagcc      420

caaaagaatg atgtctgccg ccctgggcgc tattacgaac agccagataa tggagtcctc      480

aactacccca aactggcctg ccaattcaac cggacccagc tgggcaactg ctccggcatt      540

ggggactcca cccactatgg ttacagcact gggcagccct gtgtcttcat caagatgaac      600

cgggtcatca acttctatgc aggagcaaac cagagcatga atgttacctg tgctgggaag      660

cgagatgaag atgctgagaa tctcggcaac ttcgtcatgt tccccgccaa cggcaacatc      720

gacctcatgt acttccccta ctatggcaaa aagttccacg tgaactacac acagcccctg      780

gtggctgtga agttcctgaa tgtgaccccc aacgtggagg tgaatgtaga atgtcgcatc      840

aacgccgcca acatcgccac agacgatgag cgagacaagt tcgccggccg cgtggccttc      900

aaactccgca tcaacaaaac ctga                                             924


<210>  17
<211>  891
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence encoding  His10-ATP1B3

<400>  17
atggccagat cacatcatca ccatcaccac catcaccatc atcctaggag atctacgaag       60

aacgagaaga agtccctcaa ccagagcctg gccgagtgga agctcttcat ctacaacccg      120

accaccggag aattcctggg gcgcaccgcc aagagctggg gtttgatctt gctcttctac      180

ctagtttttt atgggttcct ggctgcactc ttctcattca cgatgtgggt tatgcttcag      240

actctcaacg atgaggttcc aaaataccgt gaccagattc ctagcccagg actcatggtt      300

tttccaaaac cagtgaccgc attggaatat acattcagta ggtctgatcc aacttcgtat      360

gcagggtaca ttgaagacct taagaagttt ctaaaaccat atactttaga agaacagaag      420

aacctcacag tctgtcctga tggagcactt tttgaacaga agggtccagt ttatgttgca      480

tgtcagtttc ctatttcatt acttcaagca tgcagtggta tgaatgatcc tgattttggc      540

tattctcaag gaaacccttg tattcttgtg aaaatgaaca gaataattgg attaaagcct      600

gaaggagtgc caaggataga ttgtgtttca aagaatgaag atataccaaa tgtagcagtt      660

tatcctcata atggaatgat agacttaaaa tatttcccat attatgggaa aaaactgcat      720

gttgggtatc tacagccatt ggttgctgtt caggtcagct ttgctcctaa caacactggg      780

aaagaagtaa cagttgagtg caagattgat ggatcagcca acctaaaaag tcaggatgat      840

cgtgacaagt ttttgggacg agttatgttc aaaatcacag cacgtgcata g               891


<210>  18
<211>  288
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence encoding  Human His6-FXYD1

<400>  18
atgggcagca gccatcatca tcatcatcac tccgcgggtg aaaacctgta cttccagggt       60

accaaggcag aaagtccaaa ggaacacgac ccgttcactt acgactacca gtccctgcag      120

atcggaggcc tcgtcatcgc cgggatcctc ttcatcctgg gcatcctcat cgtgctgagc      180

agaagatgcc ggtgcaagtt caaccagcag cagaggactg gggaacccga tgaagaggag      240

ggaactttcc gcagctccat ccgccgtctg tccacccgca ggcggtag                   288


<210>  19
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence encoding Human His6-FXYD1

<400>  19

Met Gly Ser Ser His His His His His His Ser Ala Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Thr Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe 
            20                  25                  30          


Thr Tyr Asp Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly 
        35                  40                  45              


Ile Leu Phe Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg 
    50                  55                  60                  


Cys Lys Phe Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu 
65                  70                  75                  80  


Gly Thr Phe Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                85                  90                  95  


