                         SEQUENCE LISTING

<110>  The University of Queensland
 
<120>  Neuroprotective agents derived from spider venom peptides

<130>  150361PAU

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  390
<212>  DNA
<213>  Hadronyche infensa

<400>  1
atgaaatttc caaacttcga agtaatgctt cttctggtgt ggtctttaac gctttatgca       60

gttggtgatg caaaatatga agatttattg aaaaatgctt tagatgcaaa gttattgaat      120

gcatttgtgg aaacgattca attaaaaagc catgggaaga gaaatgagtg cataaggaaa      180

tggttgtctt gtgttgatcg gaaaaatgat tgctgtgagg ggctcgaatg ctataagagg      240

cgacattcgt tcgaagtatg tgtacccatt ccgggattct gcttagtaaa gtggaagcaa      300

tgcgatggac gagaacggga ttgctgcgca ggtcttgaat gctggaagag gagtggaaat      360

aagtcctcag tctgtgcacc gattacatga                                       390


<210>  2
<211>  129
<212>  PRT
<213>  Hadronyche infensa

<400>  2

Met Lys Phe Pro Asn Phe Glu Val Met Leu Leu Leu Val Trp Ser Leu 
1               5                   10                  15      


Thr Leu Tyr Ala Val Gly Asp Ala Lys Tyr Glu Asp Leu Leu Lys Asn 
            20                  25                  30          


Ala Leu Asp Ala Lys Leu Leu Asn Ala Phe Val Glu Thr Ile Gln Leu 
        35                  40                  45              


Lys Ser His Gly Lys Arg Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys 
    50                  55                  60                  


Val Asp Arg Lys Asn Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg 
65                  70                  75                  80  


Arg His Ser Phe Glu Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val 
                85                  90                  95      


Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu 
            100                 105                 110         


Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile 
        115                 120                 125             


Thr 
    


<210>  3
<211>  390
<212>  DNA
<213>  Hadronyche infensa

<400>  3
atgaaatttc caaacttcga agtaatgctt cttctggtgt ggtctttaac gctttatgca       60

gttggtgatg caaaatatga agatttattg aaaaatgctt tagatgcaaa gttatcgaat      120

gcatttgtgg aaacgattca attaaaaagc catgggaaga gaaatgagtg cataaggaaa      180

tggttgtctt gtgttgatcg gaagaatgat tgctgtgagg ggctcgaatg ctataagagg      240

cgacattcgt tcgaagtatg tgtacccatt ccgggattct gcttagtaaa gtggaagcaa      300

tgcgatggac gagaacggga ttgctgccca ggtcttgaat gctggaagag gagtggaaat      360

aagtcctcag tctgtgcacc aattacatga                                       390


<210>  4
<211>  129
<212>  PRT
<213>  Hadronyche infensa

<400>  4

Met Lys Phe Pro Asn Phe Glu Val Met Leu Leu Leu Val Trp Ser Leu 
1               5                   10                  15      


Thr Leu Tyr Ala Val Gly Asp Ala Lys Tyr Glu Asp Leu Leu Lys Asn 
            20                  25                  30          


Ala Leu Asp Ala Lys Leu Ser Asn Ala Phe Val Glu Thr Ile Gln Leu 
        35                  40                  45              


Lys Ser His Gly Lys Arg Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys 
    50                  55                  60                  


Val Asp Arg Lys Asn Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg 
65                  70                  75                  80  


Arg His Ser Phe Glu Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val 
                85                  90                  95      


Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Pro Gly Leu 
            100                 105                 110         


Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile 
        115                 120                 125             


Thr 
    


<210>  5
<211>  456
<212>  DNA
<213>  Hadronyche infensa

<400>  5
atgaaactca ggatcacgct tgctctgaca tctgtgctgg cattttgcgt ctttggagat       60

aaagaaaatg aaaatttaat ggaaaatctt ttggaagacg acctattgga tattttcacg      120

gacgctattc atatggaacg ccaagaaaca aatcaggagt gcatagcgaa atggaaatca      180

tgcgctggca gaaaactgga ttgttgtgaa ggtcttgagt gctggaagag gagatgggga      240

catgaagtgt gcgttccaat tacacaaaag attttactgt ttagaaaagt ggaaaagtca      300

tgttttgaga ggaaatatga ttgctgtgaa gaacttgaat gctgggagag gagaggaaat      360

aagacaccca gtatgcgcac caaagcagta aggtcagtca gtggtcatga ggctctcagt      420

gttgcgctcc tcaaaacttg tatacattac aaataa                                456


<210>  6
<211>  151
<212>  PRT
<213>  Hadronyche infensa

<400>  6

Met Lys Leu Arg Ile Thr Leu Ala Leu Thr Ser Val Leu Ala Phe Cys 
1               5                   10                  15      


Val Phe Gly Asp Lys Glu Asn Glu Asn Leu Met Glu Asn Leu Leu Glu 
            20                  25                  30          


Asp Asp Leu Leu Asp Ile Phe Thr Asp Ala Ile His Met Glu Arg Gln 
        35                  40                  45              


Glu Thr Asn Gln Glu Cys Ile Ala Lys Trp Lys Ser Cys Ala Gly Arg 
    50                  55                  60                  


Lys Leu Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Trp Gly 
65                  70                  75                  80  


His Glu Val Cys Val Pro Ile Thr Gln Lys Ile Leu Leu Phe Arg Lys 
                85                  90                  95      


Val Glu Lys Ser Cys Phe Glu Arg Lys Tyr Asp Cys Cys Glu Glu Leu 
            100                 105                 110         


Glu Cys Trp Glu Arg Arg Gly Asn Lys Thr Pro Ser Met Arg Thr Lys 
        115                 120                 125             


Ala Val Arg Ser Val Ser Gly His Glu Ala Leu Ser Val Ala Leu Leu 
    130                 135                 140                 


Lys Thr Cys Ile His Tyr Lys 
145                 150     


<210>  7
<211>  387
<212>  DNA
<213>  Hadronyche infensa

<400>  7
atgaaactca ggatcacgct tgctctgaca tcgatgctgg cattttgcgt ctttggagat       60

aaagaaaagg aaaatttaat ggaaaatctt ttggaagacg acctattgga tatattcacg      120

gacgctattc atatggaacg ccaggaaaca aatcaggagt gcatagcgaa atggaaatca      180

tgcgctggca gaaaactgga ttgttgtgaa ggtcttgagt gctggaagag gagatgggga      240

catgaagtgt gcgttccaat tacacaaaag attttctgtt tagaaaagtg gaagtcatgt      300

tttgagagga aatatgattg ctgtgaagaa cttgaatgct gggagaggag aggaaataag      360

cacccagtat gcgcaccaaa gcagtaa                                          387


<210>  8
<211>  128
<212>  PRT
<213>  Hadronyche infensa

<400>  8

Met Lys Leu Arg Ile Thr Leu Ala Leu Thr Ser Met Leu Ala Phe Cys 
1               5                   10                  15      


Val Phe Gly Asp Lys Glu Lys Glu Asn Leu Met Glu Asn Leu Leu Glu 
            20                  25                  30          


Asp Asp Leu Leu Asp Ile Phe Thr Asp Ala Ile His Met Glu Arg Gln 
        35                  40                  45              


Glu Thr Asn Gln Glu Cys Ile Ala Lys Trp Lys Ser Cys Ala Gly Arg 
    50                  55                  60                  


Lys Leu Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Trp Gly 
65                  70                  75                  80  


His Glu Val Cys Val Pro Ile Thr Gln Lys Ile Phe Cys Leu Glu Lys 
                85                  90                  95      


Trp Lys Ser Cys Phe Glu Arg Lys Tyr Asp Cys Cys Glu Glu Leu Glu 
            100                 105                 110         


Cys Trp Glu Arg Arg Gly Asn Lys His Pro Val Cys Ala Pro Lys Gln 
        115                 120                 125             


<210>  9
<211>  390
<212>  DNA
<213>  Hadronyche infensa

<400>  9
atgaaatttc caaacttcga agtaatgctt cttctggtgt ggtctttaac gctttatgca       60

gttggtgatg caaaatatga agatttattg aaaaatgctt tagatgcaaa gttatcgaat      120

gcatttgtgg aaacgattca attaaaaagc catgggaaga gaaatgagtg cataaggaaa      180

tggttgtctt gtgttgatcg gaaaaatgat tgctgtgagg ggctcgaatg ctataagagg      240

cgacattcgt tcgaagtatg tgtacccatt ccgggattct gcttagtaaa gtggaagcaa      300

tgcgatggac gagaacggga ttgctgcgca ggtcttgaat gctggaagag gagtggaaat      360

aagtcctcag tctgtgcacc aattgcatga                                       390


<210>  10
<211>  129
<212>  PRT
<213>  Hadronyche infensa

<400>  10

Met Lys Phe Pro Asn Phe Glu Val Met Leu Leu Leu Val Trp Ser Leu 
1               5                   10                  15      


Thr Leu Tyr Ala Val Gly Asp Ala Lys Tyr Glu Asp Leu Leu Lys Asn 
            20                  25                  30          


Ala Leu Asp Ala Lys Leu Ser Asn Ala Phe Val Glu Thr Ile Gln Leu 
        35                  40                  45              


Lys Ser His Gly Lys Arg Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys 
    50                  55                  60                  


Val Asp Arg Lys Asn Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg 
65                  70                  75                  80  


Arg His Ser Phe Glu Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val 
                85                  90                  95      


Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu 
            100                 105                 110         


Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile 
        115                 120                 125             


Ala 
    


<210>  11
<211>  390
<212>  DNA
<213>  Hadronyche infensa

<400>  11
atgaaatttc caaacttcga agtaatgctt cttctggtgt ggtctttaac gctttatgca       60

gttggtgatg caaaatatga agatttattg aaaaatgctt tagatgcaaa gttatcgaat      120

gcatttgtgg aaacgattca attaaaaagc catgggaaga gaaatgagtg cataaggaaa      180

tggttgtctt gtgttgatcg gaaraatgat tgctgtgagg ggctcgaatg ctataagagg      240

cgacattcgt tcgaagtatg tgtacccatt ccgggattct gcttagtaaa gtggaagcaa      300

tgcgatggac gagaacggga ttgctgcgca ggtcttgaat gctggaagag gagtggaaat      360

aagtcctcag tctgtgcacc aattgcatga                                       390


<210>  12
<211>  129
<212>  PRT
<213>  Hadronyche infensa

<400>  12

Met Lys Phe Pro Asn Phe Glu Val Met Leu Leu Leu Val Trp Ser Leu 
1               5                   10                  15      


Thr Leu Tyr Ala Val Gly Asp Ala Lys Tyr Glu Asp Leu Leu Lys Asn 
            20                  25                  30          


Ala Leu Asp Ala Lys Leu Ser Asn Ala Phe Val Glu Thr Ile Gln Leu 
        35                  40                  45              


Lys Ser His Gly Lys Arg Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys 
    50                  55                  60                  


Val Asp Arg Lys Asn Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg 
65                  70                  75                  80  


Arg His Ser Phe Glu Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val 
                85                  90                  95      


Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu 
            100                 105                 110         


Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile 
        115                 120                 125             


Ala 
    


<210>  13
<211>  228
<212>  DNA
<213>  Hadronyche infensa

<400>  13
agcaatgaat gcattcgtaa atggctgagc tgcgttgatc gtaaaaatga ttgttgtgaa       60

ggcctggaat gctataaacg tcgtcatagc tttgaagttt gtgttccgat tccgggtttt      120

tgtctggtta aatggaaaca gtgtgatggt cgtgaacgtg attgctgtgc cggtctggaa      180

tgttggaaac gtagcggtaa taaaagcagc gtttgtgcac cgatcacc                   228


<210>  14
<211>  76
<212>  PRT
<213>  Hadronyche infensa

<400>  14

Ser Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys 
        35                  40                  45              


Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75      


<210>  15
<211>  40
<212>  PRT
<213>  Psalmopeous cambridgei

<400>  15

Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val Asn Arg His Gly Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Arg Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Lys Thr Pro Lys Thr 
        35                  40  


<210>  16
<211>  75
<212>  PRT
<213>  Hadronyche infensa

<400>  16

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp 
        35                  40                  45              


Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg Ser 
    50                  55                  60                  


Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75  


<210>  17
<211>  37
<212>  PRT
<213>  Hadronyche infensa

<400>  17

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro 
        35          


<210>  18
<211>  35
<212>  PRT
<213>  Hadronyche infensa

<400>  18

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro 
        35  


<210>  19
<211>  37
<212>  PRT
<213>  Hadronyche infensa

<400>  19

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro 
        35          


<210>  20
<211>  38
<212>  PRT
<213>  Hadronyche infensa

<400>  20

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro Gly 
        35              


<210>  21
<211>  40
<212>  PRT
<213>  Hadronyche infensa

<400>  21

Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp Gly Arg Glu 
1               5                   10                  15      


Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg Ser Gly Asn Lys 
            20                  25                  30          


Ser Ser Val Cys Ala Pro Ile Thr 
        35                  40  


<210>  22
<211>  76
<212>  PRT
<213>  Hadronyche infensa

<400>  22

Ser Asn Glu Cys Ile Arg Lys Trp Lys Ser Cys Val Asp Arg Lys Asn 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys 
        35                  40                  45              


Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75      


<210>  23
<211>  76
<212>  PRT
<213>  Hadronyche infensa

<400>  23

Ser Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg His Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys 
        35                  40                  45              


Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75      


<210>  24
<211>  76
<212>  PRT
<213>  Hadronyche infensa

<400>  24

Ser Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg Arg Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys 
        35                  40                  45              


Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75      


<210>  25
<211>  78
<212>  PRT
<213>  Engineered peptide

<400>  25

Ser Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val Asn Arg His Gly 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Arg Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Lys Thr Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys 
        35                  40                  45              


Val Asn Arg His Gly Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Arg Arg Ser Phe Glu Val Cys Val Pro Lys Thr Pro Lys Thr 
65                  70                  75              


<210>  26
<211>  78
<212>  PRT
<213>  Engineered peptide

<400>  26

Ser Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val Asn Arg His Gly 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Arg Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Lys Thr Gly Asp Cys Ile Pro Lys Trp Lys Gly Cys 
        35                  40                  45              


Val Asn Arg His Gly Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg 
    50                  55                  60                  


Arg Arg Ser Phe Glu Val Cys Val Pro Lys Thr Pro Lys Thr 
65                  70                  75              


<210>  27
<211>  79
<212>  PRT
<213>  Engineered peptide

<400>  27

Ser Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Gly Gly Gly Gly Gly Gly Phe Cys Leu Val Lys Trp 
        35                  40                  45              


Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys 
    50                  55                  60                  


Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75                  


<210>  28
<211>  81
<212>  PRT
<213>  Engineered peptide

<400>  28

Ser Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val Asn Arg His Gly 
1               5                   10                  15      


Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Arg Ser Phe Glu 
            20                  25                  30          


Val Cys Val Pro Lys Thr Pro Lys Thr Ile Pro Gly Phe Cys Leu Val 
        35                  40                  45              


Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu 
    50                  55                  60                  


Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser Val Cys Ala Pro Ile 
65                  70                  75                  80  


Thr 
    


<210>  29
<211>  75
<212>  PRT
<213>  Hadronyche infensa

<400>  29

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp 
        35                  40                  45              


Gly Arg Glu Arg Asp Cys Cys Pro Gly Leu Glu Cys Trp Lys Arg Ser 
    50                  55                  60                  


Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Thr 
65                  70                  75  


<210>  30
<211>  100
<212>  PRT
<213>  Hadronyche infensa

<400>  30

Gln Glu Cys Ile Ala Lys Trp Lys Ser Cys Ala Gly Arg Lys Leu Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Trp Gly His Glu Val 
            20                  25                  30          


Cys Val Pro Ile Thr Gln Lys Ile Leu Leu Phe Arg Lys Val Glu Lys 
        35                  40                  45              


Ser Cys Phe Glu Arg Lys Tyr Asp Cys Cys Glu Glu Leu Glu Cys Trp 
    50                  55                  60                  


Glu Arg Arg Gly Asn Lys Thr Pro Ser Met Arg Thr Lys Ala Val Arg 
65                  70                  75                  80  


Ser Val Ser Gly His Glu Ala Leu Ser Val Ala Leu Leu Lys Thr Cys 
                85                  90                  95      


Ile His Tyr Lys 
            100 


<210>  31
<211>  77
<212>  PRT
<213>  Hadronyche infensa

<400>  31

Gln Glu Cys Ile Ala Lys Trp Lys Ser Cys Ala Gly Arg Lys Leu Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Trp Gly His Glu Val 
            20                  25                  30          


Cys Val Pro Ile Thr Gln Lys Ile Phe Cys Leu Glu Lys Trp Lys Ser 
        35                  40                  45              


Cys Phe Glu Arg Lys Tyr Asp Cys Cys Glu Glu Leu Glu Cys Trp Glu 
    50                  55                  60                  


Arg Arg Gly Asn Lys His Pro Val Cys Ala Pro Lys Gln 
65                  70                  75          


<210>  32
<211>  75
<212>  PRT
<213>  Hadronyche infensa

<400>  32

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp 
        35                  40                  45              


Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg Ser 
    50                  55                  60                  


Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Ala 
65                  70                  75  


<210>  33
<211>  75
<212>  PRT
<213>  Hadronyche infensa

<400>  33

Asn Glu Cys Ile Arg Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Ile Pro Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp 
        35                  40                  45              


Gly Arg Glu Arg Asp Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg Ser 
    50                  55                  60                  


Gly Asn Lys Ser Ser Val Cys Ala Pro Ile Ala 
65                  70                  75  


<210>  34
<211>  1416
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for recombinant Hi1a

<400>  34
atgatgtttt ccgcctcggc tctcgccaaa atccatcacc atcaccatca cgaagaaggt       60

aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga agtcggtaag      120

aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa actggaagag      180

aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg ggcacacgac      240

cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga caaagcgttc      300

caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa gctgattgct      360

tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct gccgaacccg      420

ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa aggtaagagc      480

gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc tgctgacggg      540

ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg cgtggataac      600

gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa acacatgaat      660

gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac agcgatgacc      720

atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta tggtgtaacg      780

gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct gagcgcaggt      840

attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa ctatctgctg      900

actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt agcgctgaag      960

tcttacgagg aagagttggc gaaagatcca cgtattgccg ccaccatgga aaacgcccag     1020

aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc cgtgcgtact     1080

gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa agacgcgcag     1140

actgattacg atatcccagg taccgaaaac ctgtattttc agagcaatga atgcattcgt     1200

aaatggctga gctgcgttga tcgtaaaaat gattgttgtg aaggcctgga atgctataaa     1260

cgtcgtcata gctttgaagt ttgtgttccg attccgggtt tttgtctggt taaatggaaa     1320

cagtgtgatg gtcgtgaacg tgattgctgt gccggtctgg aatgttggaa acgtagcggt     1380

aataaaagca gcgtttgtgc accgatcacc taataa                               1416


<210>  35
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full precursor for recombinant Hi1a

<400>  35

Met Met Phe Ser Ala Ser Ala Leu Ala Lys Ile His His His His His 
1               5                   10                  15      


His Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr 
            20                  25                  30          


Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile 
        35                  40                  45              


Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln 
    50                  55                  60                  


Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp 
65                  70                  75                  80  


Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro 
                85                  90                  95      


Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val 
            100                 105                 110         


Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu 
        115                 120                 125             


Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp 
    130                 135                 140                 


Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser 
145                 150                 155                 160 


Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile 
                165                 170                 175     


Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp 
            180                 185                 190         


Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr 
        195                 200                 205             


Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
    210                 215                 220                 


Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr 
225                 230                 235                 240 


Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn 
                245                 250                 255     


Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro 
            260                 265                 270         


Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys 
        275                 280                 285             


Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly 
    290                 295                 300                 


Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys 
305                 310                 315                 320 


Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met 
                325                 330                 335     


Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser 
            340                 345                 350         


Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly 
        355                 360                 365             


Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asp Tyr Asp 
    370                 375                 380                 


Ile Pro Gly Thr Glu Asn Leu Tyr Phe Gln Ser Asn Glu Cys Ile Arg 
385                 390                 395                 400 


Lys Trp Leu Ser Cys Val Asp Arg Lys Asn Asp Cys Cys Glu Gly Leu 
                405                 410                 415     


Glu Cys Tyr Lys Arg Arg His Ser Phe Glu Val Cys Val Pro Ile Pro 
            420                 425                 430         


Gly Phe Cys Leu Val Lys Trp Lys Gln Cys Asp Gly Arg Glu Arg Asp 
        435                 440                 445             


Cys Cys Ala Gly Leu Glu Cys Trp Lys Arg Ser Gly Asn Lys Ser Ser 
    450                 455                 460                 


Val Cys Ala Pro Ile Thr 
465                 470 


