                         SEQUENCE LISTING

<110>  Sanford Burnham Prebys Medical Discovery Institute
       The Scripps Research Institute
       Pasquale, Elena  B.
       Olson, Erika J.
       Dawson, Philip  E.
       Riedl, Stefan  J.
 
<120>  Modified Cyclic EphA4 Antagonists for Neuroprotection and Neural 
       Repair

<130>  3IPSB2.0002WO; 15-031-02PCT; 1738.1PCT/TSR2019P

<150>  US 62/193,010
<151>  2015-07-15

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor pepide antagonist

<400>  1

Lys Tyr Leu Pro Tyr Trp Pro Val Leu Ser Ser Leu 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist

<400>  2

Ala Pro Tyr Cys Val Tyr Arg Gly Ser Trp Ser Cys 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Seqeunce

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly, Gln, Asp, Leu, Ser, Phe, or Tyr

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Pro or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Tyr, Phe, Trp, Val, Leu, His or Ile

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Val or Leu

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid

<400>  3

Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Pro or Ala

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Tyr, Phe, Trp, Val, Leu, His or Ile

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Val or Leu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid

<400>  4

Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Tyr, Phe, Trp, Val, Leu, His or Ile

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Val or Leu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid

<400>  5

Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Val or Leu

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  6

Xaa Pro Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Val or Leu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  7

Pro Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Val or Leu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  8

Xaa Cys Xaa Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Pro or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  9

Xaa Xaa Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Pro or Ala

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  10

Xaa Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  11

Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  12

Xaa Pro Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  13

Pro Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  14

Xaa Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  15

Xaa Pro Tyr Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  16

Pro Tyr Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is Tyr, Phe, Trp or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  17

Tyr Cys Val Xaa Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  18

Xaa Pro Xaa Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  19

Pro Xaa Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is Tyr, Phe, Trp, Val, Leu or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  20

Xaa Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  21

Xaa Pro Tyr Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  22

Pro Tyr Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is any amino acid except Pro

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  23

Tyr Cys Val Tyr Xaa Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor cyclic peptide 
       antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla, DAla, Ala, Glu, Gly or Gln

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X is any amino acid except Pro

<400>  24

Xaa Pro Tyr Cys Val Tyr Arg Xaa Xaa Trp Xaa Cys 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any amino acid except Pro

<400>  25

Pro Tyr Cys Val Tyr Arg Xaa Xaa Trp Xaa Cys 
1               5                   10      


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for EphrinA4 receptor antagonist cyclic 
       peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any amino acid except Pro

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X is any amino acid except Pro

<400>  26

Tyr Cys Val Tyr Arg Xaa Xaa Trp Xaa Cys 
1               5                   10  


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  27

Ala Pro Tyr Cys Val Tyr Arg Gly Ser Trp Ser Cys 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  28

Pro Tyr Cys Val Tyr Arg Gly Ser Trp Ser Cys 
1               5                   10      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is DAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  29

Xaa Pro Tyr Cys Val Tyr Arg Gly Ser Trp Ser Cys 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  30

Xaa Pro Tyr Cys Val Tyr Arg Gly Ser Trp Ser Cys 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  31

Ala Pro Tyr Cys Val Tyr Arg Ala Ser Trp Ser Cys 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  32

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is DAla

<400>  33

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is D-Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  34

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  35

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  36

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  37

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is bALA

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  38

Ala Leu Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  39

Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  40

Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  41

Lys Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  42

Lys Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  43

His Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  44

Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10  


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is bAla

<400>  45

Ala Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  46

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  47

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X is bAla

<400>  48

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  49

Xaa Pro Tyr Cys Val Tyr Arg Xaa Glu Trp Glu Cys 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  50

Xaa Pro Tyr Cys Val Tyr Arg Xaa Glu Trp Glu Cys 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is D-Ala

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  51

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is D-Ala

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  52

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  53

Ala Pro Tyr Cys Val Trp Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  54

Ala Pro Tyr Cys Val Tyr Thr Xaa Glu Trp Leu Cys 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  55

Ala Pro Tyr Cys Val Tyr Asn Xaa Thr Trp Asn Cys 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  56

Ala Pro Tyr Cys Val Tyr Arg Xaa Val Trp Glu Cys 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  57

Ala Pro Val Cys Val Trp Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  58

Ala Pro Leu Cys Val Trp Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  59

Ala Pro Leu Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  60

Ala Pro Trp Cys Val Phe Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  61

Ala Pro His Cys Val Phe Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  62

Ala Pro Phe Cys Leu Tyr Thr Xaa Asp Trp Val Cys 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  63

Ala Pro Tyr Cys Val Tyr Asp Xaa Thr Trp Ile Cys 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  64

Ala Pro Tyr Cys Val Tyr Ser Xaa Thr Trp His Cys 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  65

Ala Pro Tyr Cys Val Tyr Asp Xaa Ser Trp Asn Cys 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  66

Ala Pro Tyr Cys Val Tyr Gln Xaa Tyr Trp Lys Cys 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  67

Ala Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  68

Glu Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<400>  69

Ala Pro Leu Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGKG tetrapeptide

<400>  70

Gly Gly Lys Gly 
1               


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  octanoyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  71

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  octanoyl-Gly

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  72

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  lauroyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  73

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  lauroyl-Gly

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  74

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  bAsp-lauroyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  75

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  gammaGlu-lauroyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  76

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  gammaGlu-palmitoyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  77

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys 
1               5                   10          


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  78

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  octanoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  79

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  lauroyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  80

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  bAsp-lauroyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  81

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-lauroyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  82

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-palmitoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  83

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amidePPPK(amide)G.am peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  AMIDATION

<400>  84

Pro Pro Pro Lys Gly 
1               5   


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amidePPPPPK(amide)G.am peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  85

Pro Pro Pro Pro Pro Lys Gly 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  86

Pro Pro Pro Pro Pro Pro Pro Lys Gly 
1               5                   


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (7)..(7)
<223>  octanoyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  87

Xaa Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is DAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  88

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is DAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  octanoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  89

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  90

Ala Pro Tyr Cys Val Tyr Lys Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is Ahx

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  91

Xaa Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is Ava

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  92

Xaa Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is gammaAbu

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  93

Xaa Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  94

Xaa Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  95

Gly Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is Sar

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  96

Xaa Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-lgammaGlu-lauroyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  97

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-gammaGlu-myristoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  98

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-gammaGlu-palmitoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  99

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Lys Gly 
1               5                   10                  15      


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphrinA4 receptor cyclic peptide antagonist


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  X is bAla

<220>
<221>  LIPID
<222>  (15)..(15)
<223>  gammaGlu-palmitoyl

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  100

Xaa Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys Gly Gly Gly Ser 
1               5                   10                  15      


Lys Gly 
        


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EphA4 receptor pepide antagonist


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X is bAla

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  101

Pro Tyr Cys Val Tyr Arg Xaa Ser Trp Ser Cys 
1               5                   10      


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amidePPPK(amide)Y.am peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  AMIDATION

<400>  102

Pro Pro Pro Lys Tyr
1               5   


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amidePPPPPK(amide)Y.am peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  AMIDATION

<400>  103

Pro Pro Pro Pro Pro Lys Tyr
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amidePPPPPK(amide)Y.am peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  104

Pro Pro Pro Pro Pro Pro Pro Lys Tyr
1               5           
