                         SEQUENCE LISTING

<110>  WASHINGTON UNIVERSITY
       XU, Mai
 
<120>  ANTIBODIES TO TUMOR ASSOCIATED COMPLEX N-GLYCANS WITH TERMINAL 
       GlcNAcBeta RESIDUES AND METHODS OF USE THEREOF

<130>  047563-548559

<150>  62/192,750
<151>  2015-07-15

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  1

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  2

Glu Ile Ser Lys Leu Ala Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  3

Gln Gln Trp Asn Tyr Pro Leu Tyr Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  4

Gly Phe Thr Phe Ser Asp Tyr Gly Met Ala 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  5

Phe Ile Ser Tyr Leu Ala Tyr Thr Val Phe Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  6

Glu Ala Tyr Gly Gly Gly Phe Thr Tyr 
1               5                   


<210>  7
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  8

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Tyr Leu Ala Tyr Thr Val Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Ala Tyr Gly Gly Gly Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val 
        115     


<210>  9
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  9
gaaattgtgc tcactcagtc tccagccatc acagctgcat ctctggggca aaaggtcacc       60

atcacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaccatggat ttatgaaata tccaaactgg cttctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca tttattactg ccagcagtgg aattatcctc tgtacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  10
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  10
gaggtgaagt tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt gactacggaa tggcgtgggt tcgacaggct      120

ccagggaagg ggcctgagtg ggttgcattc attagttatt tggcatatac tgtcttctat      180

gcagacactg tgacgggccg attcaccatc tctagagaga atgccaaaaa caccctgtac      240

ctggaaatga gcagtctgag gtctgaggac acagccatgt actactgttc aagggaggcg      300

tacgggggag ggtttactta ctggggccaa gggactctgg tcactgtc                   348


<210>  11
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  11
atggacttca ggctcagctt acttattttt gtccttattt taaaaggtgt ccagtgtgag       60

gtgaagttgg tggagtctgg gggaggctta gtgcagcctg gagggtcccg gaaactctcc      120

tgtgcagcct ctggattcac tttcagtgac tacggaatgg cgtgggttcg acaggctcca      180

gggaaggggc ctgagtgggt tgcattcatt agttatttgg catatactgt cttctatgca      240

gacactgtga cgggccgatt caccatctct agagagaatg ccaaaaacac cctgtacctg      300

gaaatgagca gtctgaggtc tgaggacaca gccatgtact actgttcaag ggaggcgtac      360

gggggagggt ttacttactg gggccaaggg actctggtca ctgtctctgc agccaaaacg      420

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg      480

accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct      540

ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact      600

ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac      660

gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt      720

tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag      780

cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc      840

agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca      900

gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt      960

cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca     1020

gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca     1080

caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc     1140

tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag     1200

ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc     1260

tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct     1320

gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt     1380

aaatga                                                                1386


<210>  12
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  12

Met Asp Phe Arg Leu Ser Leu Leu Ile Phe Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
    50                  55                  60                  


Glu Trp Val Ala Phe Ile Ser Tyr Leu Ala Tyr Thr Val Phe Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Glu Ala Tyr Gly Gly Gly Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  13
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  13
atggactttc gggtgcagat tttcagcttc ctgctaatca gtgtcacagt gtccagagga       60

gaaattgtgc tcactcagtc tccagccatc acagctgcat ctctggggca aaaggtcacc      120

atcacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      180

acctccccca aaccatggat ttatgaaata tccaaactgg cttctggagt cccagctcgc      240

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      300

gatgctgcca tttattactg ccagcagtgg aattatcctc tgtacacgtt cggagggggg      360

accaagctgg aaataaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         702


<210>  14
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  14

Met Asp Phe Arg Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Val Thr 
1               5                   10                  15      


Val Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala 
            20                  25                  30          


Ala Ser Leu Gly Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys 
    50                  55                  60                  


Pro Trp Ile Tyr Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr 
            100                 105                 110         


Pro Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


