                         SEQUENCE LISTING

<110>  Universite du Luxembourg
 
<120>  Long-term self-renewing neural stem cells

<130>  LUX15282PCT

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  5844
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctggggc gggcgctcgg gctgcgcggg ctctgggcag cagcagcagc agcagcagca       60

tcctctcttc ctttacttcc cttccgcttc tttctcttcc ttctccttct ttttcccccc      120

cctccccttc ttcccctaac ccttctaccc ctctcctttt tctccggagg gcgctaagtc      180

cgtgagcggt ggcagtcgcg accgcgggtg catccagttt ctgcgcccag attttattga      240

tctaatccaa agtatcttat aacttctggc tggaattaag attcttcagc ttgtctctaa      300

ccgaggaagc attgattggg agctactcat tcagaaaatt aaaagaaaga agccagaaaa      360

tattatcaac cctttgagaa cacgacacaa cgaactttat attttaccac ttccttgaat      420

agttgcagga gaaataacaa ggcattgaag aatggcagat gaacggaaag atgaagcaaa      480

ggcacctcac tggacctcag caccgctaac agaggcatct gcacactcac atccacctga      540

gattaaggat caaggcggag caggggaagg acttgtccga agcgccaatg gattcccata      600

cagggaggat gaagagggtg cctttggaga gcatgggtca cagggcacct attcaaatac      660

caaagagaat gggatcaacg gagagctgac ctcagctgac agagaaacag cagaggaggt      720

gtctgcaagg atagttcaag tagtcactgc tgaggctgta gcagtcctga aaggtgaaca      780

agagaaagaa gctcaacata aagaccagac tgcagctctg cctttagcag ctgaagaaac      840

agctaatctg cctccttctc cacccccatc acctgcctca gaacagactg tcacagtgga      900

ggaagcagca ggtggggaat cagctctggc tcccagtgta tttaaacagg caaaggacaa      960

agtctctaat tctaccttgt caaagattcc tgctttacag ggtagcacaa agtccccaag     1020

atacagctca gcctgcccta gcacgactaa aagggctaca ttttctgaca gtttattaat     1080

acagcccacc tcagcaggct ccacagaccg tttgccatac tcaaaatcag ggaacaagga     1140

cggagtaacc aagagcccag aaaagcgctc ttctctccca agaccttcct ccattctccc     1200

tcctcggcga ggtgtgtcag gagacagaga tgagaattcc ttctctctca acagttctat     1260

ctcttcttca gcacggcgga ccaccaggtc agagccaatt cgcagagcag ggaagagtgg     1320

tacctcaaca cccactaccc ctgggtctac tgccatcact cctggcaccc caccaagtta     1380

ttcttcacgc acaccaggca ctcctggaac ccctagctat cccaggaccc ctcacacacc     1440

aggaaccccc aagtctgcca tcttggtgcc gagtgagaag aaggtcgcca tcatacgtac     1500

tcctccaaaa tctcctgcga ctcccaagca gcttcggctt attaaccaac cactgccaga     1560

cctgaagaat gtcaaatcca aaatcggatc aacagacaac atcaaatacc agcctaaagg     1620

ggggcaggtt aggattttaa acaagaagat cgattttagc aaagttcagt ccagatgtgg     1680

ttccaaggat aacatcaaac attcggctgg gggcggaaat gtacaaattg ttaccaagaa     1740

aatagaccta agccatgtga catccaaatg tggctctctg aagaacatcc gccacaggcc     1800

aggtggcgga cgtgtgaaaa ttgagagtgt aaaactagat ttcaaagaaa aggcccaagc     1860

taaagttggt tctcttgata atgctcatca tgtacctgga ggtggtaatg tcaagattga     1920

cagccaaaag ttgaacttca gagagcatgc taaagcccgt gtggaccatg gggctgagat     1980

cattacacag tccccaggca gatccagcgt ggcatcaccc cgacgactca gcaatgtctc     2040

ctcgtctgga agcatcaacc tgctcgaatc tcctcagctt gccactttgg ctgaggatgt     2100

cactgctgca ctcgctaagc agggcttgtg aatatttctc atttagcatt gaaataataa     2160

tatttaggca tgagctcttg gcaggagtgg gctctgagca gttgttatat tcattcttta     2220

taaaccataa aataaataat ctcatcccca aactgtagta attgttacaa ttttctattt     2280

aaaaaatgaa tagtacatgc agaaattgac ctgatttcca tttgcaacag gaagacactg     2340

gctttacatg ggttcaattg gacaattatt tttgctctgc tctgttttgc atggagtatt     2400

attattttaa aaattgcatt tttacctttc atgtgcctga aggctatcca ctacattctg     2460

aaggccttgt taaaatccaa gctgctcatt tcactattct gtttctgagt gagaagataa     2520

aaactgccca ttgtaactta tttcaggtta aattaaacca aggagtctga ttgcaggaag     2580

ggaagagcat gtaagaaata agttttttta aagtgttatt ttgtataaat gggaagaaag     2640

attcaattaa gttattaaca tttgggacct ggataattat atcagagtat gtcagtccaa     2700

taaattattt aactaattaa aaaatagttg caaagcattt gagctgtggt tgaggaagtg     2760

gtgtaaaagt gcatccatta ggaatgatgc actttcatta ggatggactc gtgtctgatt     2820

agaatgtcag ttgatcagct agatttgtgt ccacactacc agtttcacac cccctttcca     2880

tctgtttgat acagtattat agatataaat atatatatat ttctctgtgg ccatttgtga     2940

tacttcctca tatacttgaa tattatactt ctttattcac agtatctgtg tctcctgcac     3000

cctttggtgt tgcaatttta gatatgtgaa agtagatgtt agcagggttc tctccctatt     3060

taaaaaaaat acattaaaaa agacaaaaaa ttttagcatg aagttgcttt ctgtaacaac     3120

tcaaagccgt aaccctgttt tagtgccaga tacaagtctc tcccgtgatg ctagacaaaa     3180

aattattttt ctttgctttc accaacatgg agtttgtggg ggtgggtcca gttatacatg     3240

aaagggttta cagattgttg gtttaagatt atggatttat ctcattttta atcacaggat     3300

agtttggggt ttattcctat tattattcat gaaaccgact taagattttt tctttatttt     3360

tctttttttt tccatttgct aaagttgaaa gttgaaacta actataatag tttgaaacat     3420

gttttctcat ttttccaaat agtatctgtt tattaaattc tctaatagaa gatgtttgtc     3480

tttcttaccc aaagtaaaga tcccctgatc agaaagaaaa aatacaatac tttgggaagc     3540

tatagctata aaacacttga gacacagata tctaaatcag tttttttcca agactccaac     3600

attgcactct gtaaagtaac acactgtgat ctagtattat ttatcagtag ataatactgt     3660

tctgactgta tatacagtct agaactcaca aatcaattag ttcctctcac aaatcattca     3720

tcttagactt acaaataagg aatgaaatag tcaatggcct gattaaggca aagagctacc     3780

aggctagatg gacacttttt aaaaatttta tctgttcttt ttcttgctca gggctggtag     3840

gttggatctg aaccattaaa atcaaatggt ccactaggcg tatgatctct ttgagccaaa     3900

tcagttcctg aatataaagg aggaaatgat gaggatgtac tgaggcaacg gggaagtata     3960

gaaacatcca agacaaaagc caagggatgc aaaggcagag acacaggtgc tttttggtga     4020

cccagtggat atggcaacca gtgtaactgc catacaagaa accctaggag caaacccaca     4080

ccactcattc tcagctaaga gattttacac aggcaaacgt gtcttaaacc atctataaat     4140

cagttatttt atatgacagt caaaacctta gaaaccttag gatcattata tctattttct     4200

gcctattaat tgctgtgagg tttgatttga ccaatctggg caatttattc atcagcttcc     4260

cttgaagtgc accagaaaat agaagaaagg tgtgtggaga cttagggtat tttattacat     4320

gttttcatag tcttaaatag tgattaaatt tctctagaaa gaagttaaca gctcattaga     4380

aaagttttaa cctgtgaaat aagtattttt ctcaacattc tttaaagttt ttatataagt     4440

taacactagg taaacattct gcatactaga agtcagttta ttacaaatac atgtcaaaaa     4500

taaagattat acaaggcacc aaactactag atttggcatt aaaacaaatg tttatttcta     4560

atcacaacaa aattataatg aataaatgtt cttgctttgt atggaaatac aattctttat     4620

taaagttaac agaaaggaac tgatcgtttg taccagtaaa agagagaaac acacaggtta     4680

aatatcttct tgtggggtta aggggtagaa cctatcttgc cttcactctc aagataacga     4740

ctcaaattaa gctttttgag caccactctt gtggggacac acatacgctg atctaggaat     4800

gaaatcttcg tggtctcaat tctagatcta ctatgccagt ttctctctgg ctttagcctt     4860

tgagaacctg tataagaata cgtaagtaat ccagagctgt gaagagttta aaggccaact     4920

tctccagtga actcaacctc tgggtcactt gcaaccagaa attggatacc tcataatgat     4980

gcaggaaaga cccgagttca tgatgagttt caaaggccac gttcatttag gaaccaactc     5040

tctctggatt tacctgctga gttccagcag cgtgatgggc tgacatccca cctacaagta     5100

tgacacctgt gtaacaccag ctaggtacgg ctggagaagg ctgaagagag aatgccatta     5160

aatggaagaa tgtactgatt gtagtgacct tctccacaca cacacacaca cacacacaca     5220

cacacaccta cagtaataca gcaagcgtgg aataatcagc caatatataa cattccatca     5280

gtattttatt aaggaaataa cctgaatgtg gttgattttg acatagctgc aattacagtt     5340

ttcttctatt tttcaagcca caataaggaa aataaactac tcatggtcta aatactagag     5400

ataaagtaga ttcatggctt ggtaaggaaa ttttaagcat tccttcaaag attgacgtgc     5460

taaaataagc attgatgttt tgagtttttt tacacctagg atttttagct tgggtgtgta     5520

ggtgaaggcc aagactctct gcaggaaaaa gcttattttc aaactcagaa aataaaatgt     5580

caatcataaa aatctacttc aactttagca aaaagaaaaa aaaatcaaca aaaagtatac     5640

tctgtatgct gggattccga ggttccaaca cactgttaca aatctgtggg gggtttcttt     5700

cttctgataa ttctagagcc tgttaccata gaaaggcatt tcttcaatgg ctggttgtag     5760

ttagttcatg tttttcaatc aaatttgcaa atgtatttgt tgctgtatag tgattgtttt     5820

gcaaaataaa attgcttgtc acct                                            5844


<210>  2
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser 
1               5                   10                  15      


Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys 
            20                  25                  30          


Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe 
        35                  40                  45              


Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
    50                  55                  60                  


Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
65                  70                  75                  80  


Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                85                  90                  95      


Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
            100                 105                 110         


Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu 
        115                 120                 125             


Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
    130                 135                 140                 


Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala 
145                 150                 155                 160 


Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asn Ser Thr Leu 
                165                 170                 175     


Ser Lys Ile Pro Ala Leu Gln Gly Ser Thr Lys Ser Pro Arg Tyr Ser 
            180                 185                 190         


Ser Ala Cys Pro Ser Thr Thr Lys Arg Ala Thr Phe Ser Asp Ser Leu 
        195                 200                 205             


Leu Ile Gln Pro Thr Ser Ala Gly Ser Thr Asp Arg Leu Pro Tyr Ser 
    210                 215                 220                 


Lys Ser Gly Asn Lys Asp Gly Val Thr Lys Ser Pro Glu Lys Arg Ser 
225                 230                 235                 240 


Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg Arg Gly Val Ser 
                245                 250                 255     


Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser Ser Ile Ser Ser 
            260                 265                 270         


Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg Arg Ala Gly Lys 
        275                 280                 285             


Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr Ala Ile Thr Pro 
    290                 295                 300                 


Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly Thr Pro Gly Thr 
305                 310                 315                 320 


Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr Pro Lys Ser Ala 
                325                 330                 335     


Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile Arg Thr Pro Pro 
            340                 345                 350         


Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile Asn Gln Pro Leu 
        355                 360                 365             


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Asp Asn Ile 
    370                 375                 380                 


Lys Tyr Gln Pro Lys Gly Gly Gln Val Arg Ile Leu Asn Lys Lys Ile 
385                 390                 395                 400 


Asp Phe Ser Lys Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys 
                405                 410                 415     


His Ser Ala Gly Gly Gly Asn Val Gln Ile Val Thr Lys Lys Ile Asp 
            420                 425                 430         


Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Lys Asn Ile Arg His 
        435                 440                 445             


Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser Val Lys Leu Asp Phe 
    450                 455                 460                 


Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Ala His His 
465                 470                 475                 480 


Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser Gln Lys Leu Asn Phe 
                485                 490                 495     


Arg Glu His Ala Lys Ala Arg Val Asp His Gly Ala Glu Ile Ile Thr 
            500                 505                 510         


Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro Arg Arg Leu Ser Asn 
        515                 520                 525             


Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu Ser Pro Gln Leu Ala 
    530                 535                 540                 


Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala Lys Gln Gly Leu 
545                 550                 555                 


<210>  3
<211>  1817
<212>  DNA
<213>  Homo sapiens

<400>  3
cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt       60

ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt ccccgcggtt      120

cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg cggcggtggc      180

agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg tggcctttga      240

ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca ccaagccctc      300

ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc accatctaga      360

gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact tcgtgcgcct      420

cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg tgtcagagga      480

cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt cagagctgga      540

caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc acccgggctt      600

ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct tccagtacag      660

gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca cctggaagga      720

ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc acctggaggc      780

ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc agctggagga      840

cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg ccggcctgct      900

gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca cccagtatat      960

ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg agctgctggg     1020

gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca ttggcctggc     1080

gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtact ggttcacggt     1140

ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg ggctgctgtc     1200

ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg ccttcgaccc     1260

tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct acttcgtgtc     1320

tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca tccagcgccc     1380

cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca gcccccaggc     1440

cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc atgcgctgag     1500

tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc tggtcctgca     1560

ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg ggtgcccccc atgccctccc     1620

tgctgccagg ctcccactgc ccctgcacct gcttctcagc gcaacagctg tgtgtgcccg     1680

tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc tcccagggtc ctgggggctg     1740

ctgcactgcc ctccgccctt ccctgacact gtctgctgcc ccaatcaccg tcacaataaa     1800

agaaactgtg gtctcta                                                    1817


<210>  4
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  5
<211>  2993
<212>  DNA
<213>  Homo sapiens

<400>  5
tgtgacagcc cccgggccgc ctgcacttgc agcctccttc cccccgagcg gagctgcggg       60

gccggccggg ccggggctgg accccgggaa cccggacgcg gccgcccggg cccgcgggcg      120

gggggatcgg cgggggggac ccgcggggtg accggcggca ggagccgcca ccatggagtt      180

ccgccaggag gagtttcgga agctagcggg tcgtgctctc gggaagctgc accgccttct      240

ggagaagcgg caggaaggcg cggagacgct ggagctgagt gcggatgggc gcccggtgac      300

cacgcagacc cgggacccgc cggtggtgga ctgcacctgc ttcggcctcc ctcgccgcta      360

cattatcgcc atcatgagtg gtctgggctt ctgcatcagc tttggcatcc gctgcaacct      420

gggcgtggcc atcgtctcca tggtcaataa cagcacgacc caccgcgggg gccacgtggt      480

ggtgcagaaa gcccagttca gctgggatcc agagactgtc ggcctcatac acggctcctt      540

tttctggggc tacattgtca ctcagattcc aggaggattt atctgtcaaa aatttgcagc      600

caacagagtt ttcggctttg ctattgtggc aacatccact ctaaacatgc tgatcccctc      660

agctgcccgc gtccactatg gctgtgtcat cttcgtgagg atcctgcagg ggttggtaga      720

gggggtcaca taccccgcct gccatgggat ctggagcaaa tgggccccac ccttagaacg      780

gagtcgcctg gcgacgacag ccttttgtgg ttcctatgct ggggcggtgg tcgcgatgcc      840

cctcgccggg gtccttgtgc agtactcagg atggagctct gttttctacg tctacggcag      900

cttcgggatc ttctggtacc tgttctggct gctcgtctcc tacgagtccc ccgcgctgca      960

ccccagcatc tcggaggagg agcgcaagta catcgaggac gccatcggag agagcgcgaa     1020

actcatgaac cccctcacga agtttagcac tccctggcgg cgcttcttca cgtctatgcc     1080

agtctatgcc atcatcgtgg ccaacttctg ccgcagctgg acgttctacc tgctgctcat     1140

ctcccagccc gcctacttcg aagaagtgtt cggcttcgag atcagcaagg taggcctggt     1200

gtccgcgctg ccccacctgg tcatgaccat catcgtgccc atcggcggcc agatcgcgga     1260

cttcctgcgg agccgccgca tcatgtccac caccaacgtg cgcaagttga tgaactgcgg     1320

aggcttcggc atggaagcca cgctgctgtt ggtggtcggc tactcgcact ccaagggcgt     1380

ggccatctcc ttcctggtcc tagccgtggg cttcagcggc ttcgccatct ctgggttcaa     1440

cgtgaaccac ctggacatag ccccgcgcta cgccagcatc ctcatgggca tctccaacgg     1500

cgtgggcaca ctgtcgggca tggtgtgccc catcatcgtg ggggccatga ctaagcacaa     1560

gactcgggag gagtggcagt acgtgttcct aattgcctcc ctggtgcact atggaggtgt     1620

catcttctac ggggtctttg cttctggaga gaagcagccg tgggcagagc ctgaggagat     1680

gagcgaggag aagtgtggct tcgttggcca tgaccagctg gctggcagtg acgacagcga     1740

aatggaggat gaggctgagc ccccgggggc accccctgca cccccgccct cctatggggc     1800

cacacacagc acatttcagc cccccaggcc cccaccccct gtccgggact actgaccatg     1860

tgcctcccac tgaatggcag tttccaggac ctccattcca ctcatctctg gcctgagtga     1920

cagtgtcaag gaaccctgct cctctctgtc ctgcctcagg cctaagaagc actctccctt     1980

gttcccagtg ctgtcaaatc ctctttcctt cccaattgcc tctcaggggt agtgaagctg     2040

cagactgaca gtttcaagga tacccaaatt cccctaaagg ttccctctcc acccgttctg     2100

cctcagtggt ttcaaatctc tcctttcagg gctttatttg aatggacagt tcgacctctt     2160

actctctctt gtggttttga ggcacccaca ccccccgctt tcctttatct ccagggactc     2220

tcaggctaac ctttgagatc actcagctcc catctccttt cagaaaaatt caaggtcctc     2280

ctctagaagt ttcaaatctc tcccaactct gttctgcatc ttccagattg gtttaaccaa     2340

ttactcgtcc ccgccattcc agggattgat tctcaccagc gtttctgatg gaaaatggcg     2400

gtttcaagtc cccgattccg tgcccacttc acatctcccc taccagcaga ttctgcgaaa     2460

gcaccaaatt tctcaagacc ctcttctccc tagcttagca taatgtctgg ggaaacaacc     2520

aaaatcgcaa ttttaacaat atgcctctct acccccgtgc actttttctg acatggtttt     2580

caggtctaaa tagtggctgc tccagtccat gaactcaaag gtttgaagct accaccattg     2640

aactccccca tggtggtttc atgatgcccc ctccccaatt cctcgcactt tattctcctg     2700

ggtggtttcg aactaccctg tttctcagtg gccatttgtt gtgtccctca ggggcttaat     2760

gactcaaaat ctgggatcct tcccctctca gacacccctc tttcagctta gaatttgggg     2820

aacctataga gaagtcacag aatcccatga aagggaatgg ggcaggagcc aggggtgttt     2880

tttcccagtg cagggttgtg tctttgtgtc tctgtctctg tgactgtaaa tcctgccctg     2940

ccccactccc aataaaagct ttggtgtata ggctcaaaaa aaaaaaaaaa aaa            2993


<210>  6
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Phe Arg Gln Glu Glu Phe Arg Lys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Gly Lys Leu His Arg Leu Leu Glu Lys Arg Gln Glu Gly Ala Glu Thr 
            20                  25                  30          


Leu Glu Leu Ser Ala Asp Gly Arg Pro Val Thr Thr Gln Thr Arg Asp 
        35                  40                  45              


Pro Pro Val Val Asp Cys Thr Cys Phe Gly Leu Pro Arg Arg Tyr Ile 
    50                  55                  60                  


Ile Ala Ile Met Ser Gly Leu Gly Phe Cys Ile Ser Phe Gly Ile Arg 
65                  70                  75                  80  


Cys Asn Leu Gly Val Ala Ile Val Ser Met Val Asn Asn Ser Thr Thr 
                85                  90                  95      


His Arg Gly Gly His Val Val Val Gln Lys Ala Gln Phe Ser Trp Asp 
            100                 105                 110         


Pro Glu Thr Val Gly Leu Ile His Gly Ser Phe Phe Trp Gly Tyr Ile 
        115                 120                 125             


Val Thr Gln Ile Pro Gly Gly Phe Ile Cys Gln Lys Phe Ala Ala Asn 
    130                 135                 140                 


Arg Val Phe Gly Phe Ala Ile Val Ala Thr Ser Thr Leu Asn Met Leu 
145                 150                 155                 160 


Ile Pro Ser Ala Ala Arg Val His Tyr Gly Cys Val Ile Phe Val Arg 
                165                 170                 175     


Ile Leu Gln Gly Leu Val Glu Gly Val Thr Tyr Pro Ala Cys His Gly 
            180                 185                 190         


Ile Trp Ser Lys Trp Ala Pro Pro Leu Glu Arg Ser Arg Leu Ala Thr 
        195                 200                 205             


Thr Ala Phe Cys Gly Ser Tyr Ala Gly Ala Val Val Ala Met Pro Leu 
    210                 215                 220                 


Ala Gly Val Leu Val Gln Tyr Ser Gly Trp Ser Ser Val Phe Tyr Val 
225                 230                 235                 240 


Tyr Gly Ser Phe Gly Ile Phe Trp Tyr Leu Phe Trp Leu Leu Val Ser 
                245                 250                 255     


Tyr Glu Ser Pro Ala Leu His Pro Ser Ile Ser Glu Glu Glu Arg Lys 
            260                 265                 270         


Tyr Ile Glu Asp Ala Ile Gly Glu Ser Ala Lys Leu Met Asn Pro Leu 
        275                 280                 285             


Thr Lys Phe Ser Thr Pro Trp Arg Arg Phe Phe Thr Ser Met Pro Val 
    290                 295                 300                 


Tyr Ala Ile Ile Val Ala Asn Phe Cys Arg Ser Trp Thr Phe Tyr Leu 
305                 310                 315                 320 


Leu Leu Ile Ser Gln Pro Ala Tyr Phe Glu Glu Val Phe Gly Phe Glu 
                325                 330                 335     


Ile Ser Lys Val Gly Leu Val Ser Ala Leu Pro His Leu Val Met Thr 
            340                 345                 350         


Ile Ile Val Pro Ile Gly Gly Gln Ile Ala Asp Phe Leu Arg Ser Arg 
        355                 360                 365             


Arg Ile Met Ser Thr Thr Asn Val Arg Lys Leu Met Asn Cys Gly Gly 
    370                 375                 380                 


Phe Gly Met Glu Ala Thr Leu Leu Leu Val Val Gly Tyr Ser His Ser 
385                 390                 395                 400 


Lys Gly Val Ala Ile Ser Phe Leu Val Leu Ala Val Gly Phe Ser Gly 
                405                 410                 415     


Phe Ala Ile Ser Gly Phe Asn Val Asn His Leu Asp Ile Ala Pro Arg 
            420                 425                 430         


Tyr Ala Ser Ile Leu Met Gly Ile Ser Asn Gly Val Gly Thr Leu Ser 
        435                 440                 445             


Gly Met Val Cys Pro Ile Ile Val Gly Ala Met Thr Lys His Lys Thr 
    450                 455                 460                 


Arg Glu Glu Trp Gln Tyr Val Phe Leu Ile Ala Ser Leu Val His Tyr 
465                 470                 475                 480 


Gly Gly Val Ile Phe Tyr Gly Val Phe Ala Ser Gly Glu Lys Gln Pro 
                485                 490                 495     


Trp Ala Glu Pro Glu Glu Met Ser Glu Glu Lys Cys Gly Phe Val Gly 
            500                 505                 510         


His Asp Gln Leu Ala Gly Ser Asp Asp Ser Glu Met Glu Asp Glu Ala 
        515                 520                 525             


Glu Pro Pro Gly Ala Pro Pro Ala Pro Pro Pro Ser Tyr Gly Ala Thr 
    530                 535                 540                 


His Ser Thr Phe Gln Pro Pro Arg Pro Pro Pro Pro Val Arg Asp Tyr 
545                 550                 555                 560 


<210>  7
<211>  9433
<212>  DNA
<213>  Homo sapiens

<400>  7
cttatttctt atgaatgtcg gatagctgca ccagcttggt ggggaaaggg tttgatgaat       60

agcacaaaga cactggctgt tccctggagg ctgtcccttt aaaggagaat cttagtttat      120

tctgggggga ggggatgcac acattagagt aggaaagagg gcttggaata aaatgaaaac      180

actccccctt catagtcatt gtactgaaat gcaaagactg cttcctaagc tggagatgct      240

aaccttgggt agctccttct gttctcttca aggggaattt tgtcaggcta tggattcatt      300

tacaactgtt agtcatgtgg gcatgtgtga ggaaacagat gccagtttta atgtatttag      360

cccgaagttc caatttgata ggagccactg tcagtctctg aggttccacc aaaatatgga      420

acttgatttt ggacactttg acgaaagaga taagacatcc aggaacatgc gaggctcccg      480

gatgaatggg ttgcctagcc ccactcacag cgcccactgt agcttctacc gaaccagaac      540

cttgcaggca ctgagtaatg agaagaaagc caagaaggta cgtttctacc gcaatgggga      600

ccgctacttc aaggggattg tgtacgctgt gtcctctgac cgttttcgca gctttgacgc      660

cttgctggct gacctgacgc gatctctgtc tgacaacatc aacctgcctc agggagtgcg      720

ttacatttac accattgatg gatccaggaa gatcggaagc atggatgaac tggaggaagg      780

ggaaagctat gtctgttcct cagacaactt ctttaaaaag gtggagtaca ccaagaatgt      840

caatcccaac tggtctgtca acgtaaaaac atctgccaat atgaaagccc cccagtcctt      900

ggctagcagc aacagtgcac aggccaggga gaacaaggac tttgtgcgcc ccaagctggt      960

taccatcatc cgcagtgggg tgaagcctcg gaaggctgtg cgtgtgcttc tgaacaagaa     1020

gacagcccac tcttttgagc aagtcctcac tgatatcaca gaagccatca aactggagac     1080

cggggttgtc aaaaaactct acactctgga tggaaaacag gtaacttgtc tccatgattt     1140

ctttggtgat gatgatgtgt ttattgcctg tggtcctgaa aaatttcgct atgctcagga     1200

tgatttttct ctggatgaaa atgaatgccg agtcatgaag ggaaacccat cagccacagc     1260

tggcccaaag gcatccccaa cacctcagaa gacttcagcc aagagccctg gtcctatgcg     1320

ccgaagcaag tctccagctg actcagcaaa cggaacctcc agcagccagc tctctacccc     1380

caagtctaag cagtctccca tctctacgcc caccagtcct ggcagcctcc ggaagcacaa     1440

ggacctgtac ctgcctctgt ccttggatga ctcggactcg cttggtgatt ccatgtaaag     1500

gaggggagag tgctcagagt ccagagtaca aatccaagcc tatcattgta gtagggtact     1560

tctgctcaag tgtccaacag ggctattggt gctttcaagt ttttattttg ttgttgttgt     1620

tattttgaaa aacacattgt aatatgttgg gtttattttc ctgtgatttc tcctctgggc     1680

cactgatcca cagttaccaa ttatgagaga tagattgata accatccttt ggggcagcat     1740

tccagggatg caaaatgtgc tagtccatga cctttcaatg gaaagcttag gtgcctgcgt     1800

tatatttgcc ctgtctaatt ttgcccatac agtcttcctt ctgtagaggg ctgtttacat     1860

atacagcact taaaatgttt gtgtgggaaa aaaaaaactc attggcagat ccaagaatga     1920

caaacacaag tgcccctttt ctctggatct caagaatggt ggaggaccct ggaaggacag     1980

caaggcagct ccccagcctc actcttcact cctgattgag gcccgggttt gttgtccagc     2040

accaattctg gctgtcaatg gggagaaata aaccaacaac ttataattgt gacaccagat     2100

gcttaggatc ctggtgctgg gttagctaag agaatagaca gaattggaaa atactgcaga     2160

catttccgaa gagtttataa agcacagtga attcctggtc aatctctcca ctgaggcaat     2220

ttggaatcaa taagcaattg ataatagttt ggagtaaggg acttcatata cctgattcct     2280

ctagaaggct gtctaacata ccacatgatt acatgaactg tatggtatcc atctatctct     2340

gttctattga atgccttgtt aacagccaac actgaaaaca ctgtgagaat ttgttttcag     2400

gtctgacacc tttcagtctc tttttatagc aagaaatcaa tatccttttt ataaaaattc     2460

atgtctgtat ttcaggagca aactcttcag gctccttttt tataaactgg tgatttttct     2520

tttgtctaaa aaacacatga agaaaattta ccaaaaaaaa aaaaaaaagc agaagaataa     2580

tgtagtttag aaattatgct gtcactgcca aacagtaacc tccaggagaa aacaagatga     2640

atagcagagg ccaattcaat agaatcagtt ttttgatagc tttttaacag ttatgcttgc     2700

attaataatt tcaatgtgga ccagacattc taattatatt ttaaatgaaa tgttacagca     2760

tattttaagc aactcttttt atctataatc ctaatatttc atactgaaga cacagaaatc     2820

tttcacttgt ctttaacatt agaaaggatt tctctttact aaggactgat catttgaaat     2880

agttttcagt cttttgagat acaggtttat aacactgctt ttttttttct gtaatcatag     2940

cccataatgg caaagacaac taaatttaag tgaaggtcat gcatgccaat tctgtgtttg     3000

cttttagcag atatgaagat ttccttattt ctttgtaatt gtgcagatat tttgaaaggc     3060

acagcattcg aagccaagct gctgtttggc tactgaatgg cttgcagttg ttcctccact     3120

ctaaatggaa tgagcttgct gtgtgtgtgt gtggtggtgg tgggaggggg tggtgcatgt     3180

gtgtgtgtgt gtgtgcatct gcagctgctt caaaattagg aaatactaca ggacacccct     3240

gtaatggatt ggtggcaact gggtggcact gctgatgtgc actgtgtagg ggggaaccca     3300

gtggtggtgg ggtagctcag atgcccctag acaagcttca gatgtctgta gctaccagaa     3360

acattttcgg ttcaggaaaa gtgagatgat ggtagtactg gtttctggtg aaattgaaga     3420

accccaaatg atgaggatct ctttttgccc cctctccttt ttttgtagac ccattcaaaa     3480

ccattaataa gcccatttta ctaagcccct atttctttct agaagctcag ggttttctta     3540

gtgcctccca gaacattttg tagttaattg ggaaaaagtg atacttggat tagggggtgt     3600

gggcataaag aatggtggga ggcctgattt taaacttcag gccagaaccc ccaatgactc     3660

cacccatagt ctcactttag gtctcattta gtccatcacc tttattttaa gttgaggaag     3720

tggaggctgg taaagagcag gaccagagga agaatccaga tttccttatg cttgggcctc     3780

acactagctc tctgagtatt tccttgattg cggtatatgt actactagaa aataccaaat     3840

ggatatattt tctttaggat aacctttgaa ccaacaatct tcaataacaa tagtacatct     3900

tccatcttac ttttaatcga gtataaggaa atgtttcttt atggccattt tggagggagc     3960

aggggatgag gcttggcata gtccaaaatt taagtctcca ataattaatt gcattttaaa     4020

ttggcccact ttcaaggcaa ttttttttgt gtgtctgtaa ctgagctcct ccacccctgt     4080

cattcacttc caattttacc caatccaatt ttagcactca agttccattg tgttaatttc     4140

tgcacggtca acaaacatca agtcagcaag catttgccac cactccctat acttctccct     4200

ccttcttaca cacacacaca cacacacaca cacaatccat ctcttgcttg ttcctacctc     4260

ctgatttttc ttccctacag aaatagaaat agggacaaag aaggggaaaa tgtatatatt     4320

ggggctgggc tgaacaacta acttcataag tagtattaac taggggtaaa ttgagagaaa     4380

agctcctttt ctcttcactg ttttggaaag gatagccatt agcatgactg ctttgtgtcc     4440

ttatggactt tagtattagc ctagattgaa ttatagcgtt ttctagctgg aaggaacctt     4500

aagatcacat catctactcc tctactccaa atttctcatt cttcaggcca ggaaaccgag     4560

acacagaggt aaagtaattt ccccaaggtc acacagctgg ctggggcagg attgggttta     4620

caacccacat ctcctggctc ttattccagg gccttttccc actaagtagt attgccttcc     4680

attaggctcc tgagagttat ttctcagggt catgttgcat cttggagcca catgctgctg     4740

ccctgatctc agtgggaaat ccacccagca acctaataca gccccttttc cctgcattca     4800

cctggttccc atccacatgg gttgcagatg tccttgaaga gagtgaggca ttgagggcca     4860

ataggagcaa tggggtccct ggccttgtcc atctgattca ggagatcact gctccatcgt     4920

gaggagccct ctgaatagcc ccccactgaa tgcttgcctt gcccaaatgg aatggaggaa     4980

gattgatttt ctccatcagt tcaccttgtg tcatctcata atggttggtc tttccaggct     5040

gagggaaatg tttcttgttt ccagagtaga aaaagaaaga gtggaacaat agctttgttc     5100

atcctaactt tctgagatgg cttttcaaca ttttaaaaaa actagtgtgg ctaccattca     5160

ctggcaatga tttcttttag aatatgggag taagatgagc tagagaaaat aacctggtct     5220

cactgtggtt gccctcatcc acaatgtccc caaagccatc ctgctctgat gaggacaatt     5280

tccaggtata agcaaggggc tttgtgacaa aaatgtaccc tggctgatgt taaacattgg     5340

ctcctgtgtt tgcaccaaaa tagcaagctg tgtgctctat acactcttcc catcgtcttg     5400

tgtacactgc tcctgtggcc ttccacagca gaaaccaggg caaaagggtc caaacacatg     5460

gttttccttg ctgcaaggct cttcctggga actaaggggg tatttattag ttcagttcta     5520

agagacctcc ttctgggctt accccactcc tcaggtactt ctctctcctt cctccttctc     5580

ctccacagtc acaagtaacc aaggaacctg aaagtggatg tgtagctatt tgaagaaggc     5640

aaggaaccct gagattcttc tttgaatcct ctagtccaag tcttagacca gtgattggtg     5700

cttaccttga acaaaatttt gtctgtgttc ctaatccctt caatactctg ggtacaatgc     5760

tcccaatcac cctgcacatt tgattctaaa tggcttttat tttttaaaaa tccatatccc     5820

taggacaaga gaacaggatg cctatatccc caaaatgagc tccaggacac tgatgggaat     5880

gatcccaaag atcaccccac ctcagaaacg tctgtgccaa gagacttccc cagatagaaa     5940

cactgggaca gtggtttgaa cgacttcttt tatggttgtc cagtttgcta tggaaataaa     6000

aggcattgat tttttaaaaa gatgattgga acctgtcttt ggccacatag ggccacttgg     6060

atccatttcc aggccttact catatattgc cttcactgaa gggctttggc tttaagtccc     6120

agactggtct cccaagtgaa ccataagtgt tttggagctc atctggggtg aggcatgaga     6180

atgttgcccc atctatccct tcaggaaaag gtgccttccc tccctttctc ctaaagcctg     6240

gtccccagaa attgtttttg tctccaaaag tctagtatgg tctttataca cccagactct     6300

tagtgttgcg tcctgccttg tttccttgtt aaggatctat gcagacctcc cgctttggct     6360

tagctagcgt gacattggct atcatttgac aagactaact tttttttttt tttttttttg     6420

actgagtctc cctctgtcac ctaggctgga gtgcagtggc acaatcttgg ctcgctgcaa     6480

ccttcaccct tcacctccca ggtcgaagcg attctcctgc ctcagtctcc cgagtagctg     6540

ggattacagg cgtgcgccac caaatctggc tattttttta ttattattat ttttagtaga     6600

gatggggttt caccatgttg gccagactgg tcttgaactc ttggcctcaa attatctgcc     6660

cacctcggcc tcccaaagtg ctgggattac aggcatgagc caccatgccc agctgacaag     6720

actaattttt tatcccttgg tttattggct tcaacatctt ctggaatcag aggtgatttt     6780

ttcttacctt ggatgcctga gactagggga gtatagaatt ccaattggta attaaggcat     6840

ctttctgctc ctgatcagaa gggcaggtta gttgggagag gtcagatggc acaacagaag     6900

tcaccttgta agtaaggcaa agacttgaag gcattagcgt ttctcattac taggtcaata     6960

acctgaggga atcaatggct ttttgccgct ctacctcttg tgtatctctt tgacttttct     7020

ttctctgtct agtttcctct gttctcagtt tatattctat gttatcagtc tctctttcca     7080

cagtacaaac atccatcctt tctcctgtgc aattctgtct ctccctctta ttatctttat     7140

ttgtactttt tccttcctcc ctgtctaggc attgggcatg tgcctcttct tagcctgtga     7200

ttttgccttg ggactgatga taaattattt ccagattcaa tcagccctgg tcctacccca     7260

gtccaatcag aagtatgttg gtgggaatca acctgatcct ggccctttct tcttctccat     7320

tttcattcgt aatccccctc agcagatctt tacaagcagt ttccttatag ctcatgtatc     7380

tttaggtctt tgccttccaa gcactgtaca gaatactttg tggttccttt ttagtctgac     7440

attttgtgga gcagtgaagc gtgctcagag acataatcag ctgaagagaa aaaatccacc     7500

catggattta tatcagctaa atactaataa ttgattttgt ttgatgtgcc cataattttt     7560

aaagctgcaa tataatataa tgagggacca caggtaattt ctcctgtcat ttgttttggc     7620

tggatggggg tgggggagta attgcttaaa gttttaccat tacacattaa actctctata     7680

ataatcttgt ttggggcttg ctaactgttg agctgtttta actaaactgg taggcaatcg     7740

gagttgattt aaatgaaaag ataatttaac aaatctatac tataaaaaga gacatttgct     7800

taattgacat gtattttttc cttctgagtc acctaaacat ttactcttga caccaactgt     7860

tcatgatact gaatagacag tccatataag agaaattagt ggacctaaag aagccagatt     7920

gtaggtgtta atttattaaa cagagtgcaa agcccttgga aatgtcactg cttggcaata     7980

ccatatggaa tgccaaaatt tacaatgact tttctttata agttatccaa aagggatttg     8040

aacaagtaag aggttatgcc aaaatgtctc caatgtatgg tcctgtaata tattgcagct     8100

tgaagccaat gatcccttat gacttgtata caactaatgc atgttttatt gaattttgca     8160

tttcccacgt gtggtaagtt ctttaaaatg tttttgatca cctttttgtg ccattaaact     8220

tgtacagaaa atgtttttat ggccattttc aaagggagaa agtttaaaat ggaaacagcc     8280

caccctttct gccctatagc tgtagttaga attgagtacc tgtagcaaaa cagctgtaat     8340

tggtggttgt agtgttagag gtgttagctt gctagtgact agctttggag agtaaatgca     8400

tggtattgta catcacattt cttaactcgt tttaacctct gaaaagaata tattcttctt     8460

tgtagtcctt cttcccaccc ccttgccctc tccctctccc tgctcccagt tgtcttacag     8520

ttgtaaatat ctgatttgag gcccaataac tcttgccaag taaagtcagc aaacaacaaa     8580

caaaccaaaa tgtggggaaa aggcatttct caaccatctc tcagcagtta ttgatcattt     8640

cttaaggaac agcattgtga tcaaagactc aactttacgt aaaaatcagt ggtaaattgg     8700

ggttgtattt ggccatttga ttacatttca ggattgaata gttttcagaa tcacatgtaa     8760

tccaaagaca gtaggtagtg atgtccctta tccctgcagc tgttttaaga tagagacctc     8820

agaagactct gcttgaccga tgaccaataa ttatttgaaa aaaaaagaaa aaatgagaga     8880

aataaaacag atatttaaga actttagcca cctatttaga atagttatag ccagaaaaaa     8940

aaacaagggc atgagttcaa atgcattact atcagtgtcc taggcaatac ctaacctact     9000

ctgaaattgt gattcaaaag cagtatttca agaggcattc tccttttttg gtttgctgac     9060

cccacttgga ctggtaggtt tggtgaggcc cccataaacc agctggagca gacccttttc     9120

atctcctgtg cctgtaacac ccctcttccc ccaccccctc cgcaattcaa tgagggcttt     9180

cttgggtcag aggacttcaa ggttgtctag agaagtttgc catgtgtgta aggtgctgtg     9240

aactgtgagt gctgaagatt cgcagcattc aataccaggc agccaaagag ctgctcttgc     9300

aattattttg gctctcaagc tctgttcttc atcgcattct catttctgtg tacatttgca     9360

agatgtgtgt aatgtcattt tccaaaaata aaatttgatt tcaataaaaa aaaaaaaaaa     9420

aaaaaaaaaa aaa                                                        9433


<210>  8
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Thr Leu Pro Leu His Ser His Cys Thr Glu Met Gln Arg Leu 
1               5                   10                  15      


Leu Pro Lys Leu Glu Met Leu Thr Leu Gly Ser Ser Phe Cys Ser Leu 
            20                  25                  30          


Gln Gly Glu Phe Cys Gln Ala Met Asp Ser Phe Thr Thr Val Ser His 
        35                  40                  45              


Val Gly Met Cys Glu Glu Thr Asp Ala Ser Phe Asn Val Phe Ser Pro 
    50                  55                  60                  


Lys Phe Gln Phe Asp Arg Ser His Cys Gln Ser Leu Arg Phe His Gln 
65                  70                  75                  80  


Asn Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser 
                85                  90                  95      


Arg Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His 
            100                 105                 110         


Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser 
        115                 120                 125             


Asn Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg 
    130                 135                 140                 


Tyr Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser 
145                 150                 155                 160 


Phe Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile 
                165                 170                 175     


Asn Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg 
            180                 185                 190         


Lys Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys 
        195                 200                 205             


Ser Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn 
    210                 215                 220                 


Pro Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro 
225                 230                 235                 240 


Gln Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp 
                245                 250                 255     


Phe Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro 
            260                 265                 270         


Arg Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe 
        275                 280                 285             


Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly 
    290                 295                 300                 


Val Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu 
305                 310                 315                 320 


His Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu 
                325                 330                 335     


Lys Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys 
            340                 345                 350         


Arg Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser 
        355                 360                 365             


Pro Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg 
    370                 375                 380                 


Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro 
                405                 410                 415     


Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp 
            420                 425                 430         


Asp Ser Asp Ser Leu Gly Asp Ser Met 
        435                 440     


<210>  9
<211>  2449
<212>  DNA
<213>  Homo sapiens

<400>  9
gccccctgca ttgctgatgc tgctgctggc ggacatggac gtggtgaatc agctggtggc       60

tgggggtcag ttccgggtgg tcaaggagcc cctcggcttt gtgaaggtgc tgcaatgggt      120

cttcgccatc ttcgcctttg ccacatgcgg cagctacagt ggggagctcc agctgagcgt      180

ggattgtgcc aacaagaccg agagtgacct cagcatcgag gtcgagttcg agtacccctt      240

caggctgcac caagtgtact ttgatgcacc cacctgccga gggggcacca ccaaggtctt      300

cttagttggg gactactcct cgtcagccga attctttgtc accgtggccg tgtttgcctt      360

cctctactcc atgggggctc tggccaccta catcttcctg cagaacaagt accgagagaa      420

taacaaaggg cccatgctgg actttctggc cacggctgtg ttcgccttca tgtggctagt      480

tagctcatcg gcatgggcca aggggctgtc agatgtgaag atggccacag acccagagaa      540

cattatcaag gagatgcctg tctgccgcca gacagggaac acatgcaagg agctgagaga      600

ccctgtgacc tcgggactca acacctcggt ggtgttcggc ttcctgaacc tggtgctctg      660

ggtcggcaac ctgtggttcg tgtttaagga gacaggctgg gccgccccgt tcctgcgcgc      720

gcctcccggc gcccccgaga aacaaccggc acccggggac gcctacggcg atgcaggcta      780

cgggcagggc cccggcgggt acgggcccca ggattcctac gggcctcagg gcggctacca      840

gcctgactat ggtcaaccag ccggcagcgg tggcagtggc tacgggcctc agggcgacta      900

tgggcagcaa ggctacggcc cgcagggtgc acccacctcc ttctccaatc agatgtagtc      960

tggtcagtga agcccaggag gacctggggg gggcaagagc tcaggagaag gcctgccccc     1020

cttcccaccc ctatacccta ggtctccacc cctcaagcca ggagaccctg tctttgctgt     1080

ttatatatat atatattata tataaatatc tatttatctg tctgagccct gccctcactc     1140

cactcccctc atccactagg tgcccagtct tgagtgggcc ccctctctta ccccgtccct     1200

ttccctgcat cccttggccc ctctctgttt accctccctg tcccctgagg ttaaggggat     1260

ctaaaaggag gacagggagg gaacagacct cggctgtgtg gggagggtgg gcgtgacttc     1320

agactctctc ctctctctcc ctccactcct cccaactctg gccttggttc ctccagcaat     1380

gcctgcctga acaaaggccg ttagggaaat ccaactccag ggttaaagaa aggcagagat     1440

tgggggggct tggggtagag aggacagttt aggacccaag gtggtcttgg agaggaggtg     1500

tggagtggag gggtcagcag gggggttggg ttccagacag agtggatctg gagtctgaag     1560

gagaggagtg cgctagagca ttctggggtg gggcttggaa gggcgctgag ggcagggttc     1620

tagaaggggc gaggctttaa gcgaggcaga atggtgggct ccagagtagg tgggtcttgg     1680

attggtacca gagcctatgg aaagggtgtg gcttggaaca tttgggagac tgagcttgat     1740

tctaaagggg acagatcttg agcaaggcaa gaagtgggat tcaggaatgg gccaagccag     1800

ggttccagac agggtggggc ttagaatggg gcttccatgg tggtttcaga aagggcagcc     1860

cctccccatg gtgcagtgaa gaaaatgttt tacaatggct gggtttgggc agtggagagg     1920

ggacttggat aggagcttcc agatgggttt tgttaggggt gggggagaat ggctctggct     1980

acgacttggg acggaagtgg cctgagaaga gtcgagtgat atggcttgta gggtgaggcg     2040

tgggatccag agagaagcac cccaccacac acacccttcc ccactcccgt gatgaaacag     2100

ctaggttaat aggaggacag aaccaacggg tctgtgggac tggcccaccc ctcttccccc     2160

ttcccctgcg ccctccctcc ctccacacct ccacccgtcc tggggtggtt ggaggcctgg     2220

tctggagccc ctatcctgca ccctctgcta tgtctgtgat gtcagtagtg cctgtgatcg     2280

tgtgttgcca ttttgtctgg ctgtggcccc tccttctccc ctccagaccc ctaccctttc     2340

ccaaaccctt cggtattgtt caaagaaccc ccctccccaa ggaagaacaa atatgattct     2400

cctctcccaa ataaactcct taaccaccta gtcaaaaaaa aaaaaaaaa                 2449


<210>  10
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210>  11
<211>  3995
<212>  DNA
<213>  Homo sapiens

<400>  11
ggatccgcgg gacagatgag gaaggggctt aagtcactgc agccagaggg atggaggtgg       60

actgatggga gggcttctcc ggtggggtta gaagggaaaa gtagggaaag agaagtgtaa      120

ggtagatggc agaggcagag acatggaaag acagactcta gggttcctga tgatatctat      180

ctcggccaac acaaaaggga gggtacagtg gtgggggcac ccaagctagg gtgtgagtac      240

cctaagtgta ttcttctgag atgtaggcca ttcactaact cttggaacag ctacagtttc      300

acagtaggaa gaccccccca gattcactgc ccctccctta gtaaagcctc tgagaccttc      360

ctgaacattc ccttctgtct ttgccctctg ttccttccag agactatgtg cccaggcaga      420

tggattcctc ccgggcctga gaggaactgc aggaattctc ctgcctctta cccgtaaaac      480

cccaacttct ctagccctag ggcaggaagt cccaaacaat ttctacccct ttttctgcaa      540

ttctcattgg ggtgagagga ggcccaggag gagagagagc tgggctcagc ttctttttga      600

gctgctggag ccctctgtga ggaggccctc tttgctggct tctcaggaga gtgtggctag      660

gttctgcctg cctatgggaa gagggggcca gggtgtgtgg agcaagatgg tgcggtgctg      720

gtgccttggg acctggggga atgggacagc tggtcggctc agagacggcc tactttactc      780

acagctggaa tttagtgggg agaagcagct caactccaat cctggaggat tagggagatt      840

aaagtgagag aagagagaga tgtcccagag accaagagct cccaggtcag ccctctggct      900

cctggcaccc ccactgctgc ggtgggcacc cccactcctc acagtgctgc atagcgacct      960

cttccaggcc ttgctggaca tcctggacta ttatgaggct tccctctcag agagtcagaa     1020

ataccgctac caagatgaag acacgccccc tctggagcac agcccggccc acctccccaa     1080

ccaggccaat tctcccccag tgattgtcaa cacagatacc ctagaagccc caggatatga     1140

gttgcaggtg aacgggaccg agggggagat ggaatacgag gaaatcacat tggaaagggg     1200

taactcaggt ctgggcttca gcatcgcagg tggcactgac aacccacaca tcggtgacga     1260

cccatccatt ttcatcacca agatcattcc tggtggggct gcggcccagg atggccgcct     1320

cagggtcaac gacagcatcc tgtttgtaaa tgaagtggac gtgcgcgagg tgacccactc     1380

agcggcggtg gaagccctca aagaggcagg ctccatcgtt cgcctctatg tcatgcgccg     1440

gaagcccccg gctgagaagg tcatggagat caagctcatc aaggggccta aaggtcttgg     1500

cttcagcatc gcagggggcg tagggaacca gcacatccca ggagataata gcatctatgt     1560

aacaaagatc atcgaagggg gtgctgccca caaggatggg aggttgcaga ttggagacaa     1620

gatcctggcg gtcaacagtg tggggctaga ggacgtcatg catgaagatg ctgtggcagc     1680

cctgaagaac acgtatgatg ttgtctacct aaaggtggcc aagcccagca atgcctacct     1740

gagtgacagc tatgctcccc cagacatcac aacctcttat tcccagcacc tggacaatga     1800

gatcagtcac agcagctacc tgggcaccga ctaccccaca gccatgaccc ccacttcccc     1860

tcggcgctac tctccagtgg ccaaggacct gctcggggag gaagacattc cccgagaacc     1920

gaggcgaatt gtgatccacc ggggctccac gggcctgggc ttcaacatcg tgggtggcga     1980

ggacggtgaa ggcatcttca tctcctttat cctggccggg ggccctgcag acctcagtgg     2040

ggagctgcgg aagggggacc agatcctgtc ggtcaacggt gtggacctcc gaaatgccag     2100

ccatgagcag gctgccattg ccctgaagaa tgcgggtcag acggtcacga tcatcgctca     2160

gtataaacca gaagagtaca gccgattcga ggccaagatc cacgaccttc gggaacagct     2220

catgaacagc agcctgggct cagggactgc gtccttgcgg agcaacccca aaaggggttt     2280

ctacatcagg gccctgtttg attacgacaa gaccaaggac tgcggcttcc tgagccaggc     2340

cctgagcttc cgctttgggg atgtgctgca tgtcatcgat gctagtgatg aggagtggtg     2400

gcaggcacgg cgggtccact ctgacagtga gaccgacgac attgggttca tccccagcaa     2460

acggcgggtt gagcgacgag agtggtcaag gttaaaggcc aaggactggg gctccagctc     2520

tggatcgcag ggtcgagaag actcggttct gagctacgag acagtgacgc agatggaagt     2580

gcactatgct cgccccatca tcatccttgg gcccaccaag gaccgcgcca acgatgatct     2640

tctctccgag ttccccgaca agtttggatc ctgtgttccc catacgacac ggcccaagcg     2700

ggagtatgag atagatggcc gggattacca ctttgtgtcg tcccgggaga aaatggagaa     2760

ggacattcag gcgcacaagt tcattgaggc cggccagtac aacagccacc tctatgggac     2820

cagcgtccag tccgtgcgag aggtggcaga gcaggggaag cactgcatcc tcgatgtctc     2880

ggccaatgcc gtgcggcggc tgcaggcggc ccacctgcac cccatcgcca tcttcatccg     2940

cccccgctcc ctggagaatg tgctagagat taacaagcgg atcacagagg agcaagcccg     3000

caaagccttc gacagagcca ccaagctgga gcaggagttc acagagtgct tctcagccat     3060

cgtggagggt gacagctttg aggagatcta ccacaaggtg aagcgtgtca tcgaggacct     3120

ctcaggcccc tacatctggg ttccagcccg agagagactc tgattcctgc cctggcttgg     3180

cctggactcg ccctgcctcc atcacctggg cccttggtct ggactgaatt gcccaagccc     3240

ttggctcccc ccggcctccc tcccacccct tcttatttat ttcctttcta actggatcca     3300

gcctgttgga ggggggacac tcctctgcat gtatccccgc accccagaac tgggctcctg     3360

aacgccagga acctggggtc tgggggggag ctgggctcct tgttccgagc ccttgctcct     3420

taggatcccc gcccccacct gcccccaatg cacacacaga cccaccgggg gccacctgcc     3480

ctcccccatc ctctcccaca cacattccag aagtcagggc cccctcgagg agcacccgct     3540

gcagggatgc agggccacag gcctccgctc tctcctaagg cagggtctgg ggtcacccct     3600

gcctcatcgt aattccccat gttaccttga tttctcattt attttttcca ctttttttct     3660

tctcaaaggt ggttttttgg ggggagaagc aggggactcc gcagcgggcc cctgccttcc     3720

acatgccccc accatttttc tttgccggtt tgcatgagtg gaaggtctaa atgtggcttt     3780

tttttttttt ttcctgggaa tttttttggg gaaaagggag ggatgggtct agggagtggg     3840

aaatgcggga gggagggtgg ggcaggggtc gggggtcggg tgtccgggag ccagggaaga     3900

ctggaaatgc tgccgccttc tgcaatttat ttattttttt cttttgagag agtgaaagga     3960

agagacagat acttgaaaaa aaaaaaaaaa aaaaa                                3995


<210>  12
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
    50                  55                  60                  


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
65                  70                  75                  80  


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                85                  90                  95      


Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
            100                 105                 110         


Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
        115                 120                 125             


Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
    130                 135                 140                 


Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
145                 150                 155                 160 


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                165                 170                 175     


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
            180                 185                 190         


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
        195                 200                 205             


Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
    210                 215                 220                 


His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
225                 230                 235                 240 


Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                245                 250                 255     


Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
            260                 265                 270         


Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
        275                 280                 285             


Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
    290                 295                 300                 


Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
305                 310                 315                 320 


Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                325                 330                 335     


Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
            340                 345                 350         


Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
        355                 360                 365             


Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
    370                 375                 380                 


Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
385                 390                 395                 400 


Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                405                 410                 415     


Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
            420                 425                 430         


Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
        435                 440                 445             


Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
    450                 455                 460                 


Ala Ser Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
465                 470                 475                 480 


Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                485                 490                 495     


Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
            500                 505                 510         


Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
        515                 520                 525             


Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
    530                 535                 540                 


Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
545                 550                 555                 560 


Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                565                 570                 575     


Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
            580                 585                 590         


Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
        595                 600                 605             


Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
    610                 615                 620                 


His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
625                 630                 635                 640 


Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                645                 650                 655     


Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
            660                 665                 670         


Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
        675                 680                 685             


Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
    690                 695                 700                 


Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
705                 710                 715                 720 


Arg Glu Arg Leu 
                


<210>  13
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  13
gacatcagcc gatgcgaagg gcggggccgc ggctataaga gcgcgcggcc gcggtccccg       60

accctcagca gccagcccgg cccgcccgcg cccgtccgca gccgcccgcc agacgcgccc      120

agtatgaggg agatcgtgca catccaggcc ggccagtgcg gcaaccagat cggggccaag      180

ttctgggaag tcatcagtga tgagcatggc atcgacccca gcggcaacta cgtgggcgac      240

tcggacttgc agctggagcg gatcagcgtc tactacaacg aggcctcttc tcacaagtac      300

gtgcctcgag ccattctggt ggacctggaa cccggaacca tggacagtgt ccgctcaggg      360

gcctttggac atctcttcag gcctgacaat ttcatctttg gtcagagtgg ggccggcaac      420

aactgggcca agggtcacta cacggagggg gcggagctgg tggattcggt cctggatgtg      480

gtgcggaagg agtgtgaaaa ctgcgactgc ctgcagggct tccagctgac ccactcgctg      540

gggggcggca cgggctccgg catgggcacg ttgctcatca gcaaggtgcg tgaggagtat      600

cccgaccgca tcatgaacac cttcagcgtc gtgccctcac ccaaggtgtc agacacggtg      660

gtggagccct acaacgccac gctgtccatc caccagctgg tggagaacac ggatgagacc      720

tactgcatcg acaacgaggc gctctacgac atctgcttcc gcaccctcaa gctggccacg      780

cccacctacg gggacctcaa ccacctggta tcggccacca tgagcggagt caccacctcc      840

ttgcgcttcc cgggccagct caacgctgac ctgcgcaagc tggccgtcaa catggtgccc      900

ttcccgcgcc tgcacttctt catgcccggc ttcgcccccc tcacagcccg gggcagccag      960

cagtaccggg ccctgaccgt gcccgagctc acccagcaga tgttcgatgc caagaacatg     1020

atggccgcct gcgacccgcg ccacggccgc tacctgacgg tggccaccgt gttccggggc     1080

cgcatgtcca tgaaggaggt ggacgagcag atgctggcca tccagagcaa gaacagcagc     1140

tacttcgtgg agtggatccc caacaacgtg aaggtggccg tgtgtgacat cccgccccgc     1200

ggcctcaaga tgtcctccac cttcatcggg aacagcacgg ccatccagga gctgttcaag     1260

cgcatctccg agcagttcac ggccatgttc cggcgcaagg ccttcctgca ctggtacacg     1320

ggcgagggca tggacgagat ggagttcacc gaggccgaga gcaacatgaa cgacctggtg     1380

tccgagtacc agcagtacca ggacgccacg gccgaggaag agggcgagat gtacgaagac     1440

gacgaggagg agtcggaggc ccagggcccc aagtgaagct gctcgcagct ggagtgagag     1500

gcaggtggcg gccggggccg aagccagcag tgtctaaacc cccggagcca tcttgctgcc     1560

gacaccctgc tttcccctcg ccctagggct cccttgccgc cctcctgcag tatttatggc     1620

ctcgtcctcc ccacctaggc cacgtgtgag ctgctcctgt ctctgtctta ttgcagctcc     1680

aggcctgacg ttttacggtt ttgtttttta ctggtttgtg tttatatttt cggggatact     1740

taataaatct attgctgtca gataccctta aaaaaaaaaa aaaaaaaaaa aaaa           1794


<210>  14
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  15
<211>  1839
<212>  DNA
<213>  Homo sapiens

<400>  15
atcgccagtc tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag       60

agcaggatgg agaggagacg catcacctcc gctgctcgcc gctcctacgt ctcctcaggg      120

gagatgatgg tggggggcct ggctcctggc cgccgtctgg gtcctggcac ccgcctctcc      180

ctggctcgaa tgccccctcc actcccgacc cgggtggatt tctccctggc tggggcactc      240

aatgctggct tcaaggagac ccgggccagt gagcgggcag agatgatgga gctcaatgac      300

cgctttgcca gctacatcga gaaggttcgc ttcctggaac agcaaaacaa ggcgctggct      360

gctgagctga accagctgcg ggccaaggag cccaccaagc tggcagacgt ctaccaggct      420

gagctgcgag agctgcggct gcggctcgat caactcaccg ccaacagcgc ccggctggag      480

gttgagaggg acaatctggc acaggacctg gccactgtga ggcagaagct ccaggatgaa      540

accaacctga ggctggaagc cgagaacaac ctggctgcct atagacagga agcagatgaa      600

gccaccctgg cccgtctgga tctggagagg aagattgagt cgctggagga ggagatccgg      660

ttcttgagga agatccacga ggaggaggtt cgggaactcc aggagcagct ggcccgacag      720

caggtccatg tggagcttga cgtggccaag ccagacctca ccgcagccct gaaagagatc      780

cgcacgcagt atgaggcaat ggcgtccagc aacatgcatg aagccgaaga gtggtaccgc      840

tccaagtttg cagacctgac agacgctgct gcccgcaacg cggagctgct ccgccaggcc      900

aagcacgaag ccaacgacta ccggcgccag ttgcagtcct tgacctgcga cctggagtct      960

ctgcgcggca cgaacgagtc cctggagagg cagatgcgcg agcaggagga gcggcacgtg     1020

cgggaggcgg ccagttatca ggaggcgctg gcgcggctgg aggaagaggg gcagagcctc     1080

aaggacgaga tggcccgcca cttgcaggag taccaggacc tgctcaatgt caagctggcc     1140

ctggacatcg agatcgccac ctacaggaag ctgctagagg gcgaggagaa ccggatcacc     1200

attcccgtgc agaccttctc caacctgcag attcgagggg gcaaaagcac caaagacggg     1260

gaaaatcaca aggtcacaag atatctcaaa agcctcacaa tacgagttat accaatacag     1320

gctcaccaga ttgtaaatgg aacgccgccg gctcgcggtt agctgcctgc ctctcagaca     1380

cggcgctttg cccagcttga cagggagtga gcctcaccca ccccatcctc ccaatccccc     1440

tgagttccct cttcccaggc ttcccctaaa gggcctggac tgcgtcattt tcccaggaac     1500

tgcagtgccc agcccaggac gtggtacaga gtaactgtac attaaactgg cagagcttgt     1560

tagtggtaaa ggtggtgagt ccttgggtgc gcagtggagc tgctctgggg cctctgagca     1620

agcagcagcc tctgtctcac ctcttcctgt cactgggagg gccccttggg tctcgctgtg     1680

cctggacgcc aggctctctg ctttattctt tcatccctga ggctccatcg ctcagctcag     1740

tgctgactca gttcagagga ttcttccctc aggaccgcag ctcttgcagt gaataaagtt     1800

ttatgttccc tgctcttaat gttaaatatt aaaaaaaaa                            1839


<210>  16
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  17
<211>  1135
<212>  DNA
<213>  Homo sapiens

<400>  17
gggcagaggg aataagaggc tgcctctgcc caccagtcct gccgcccagg acccgcagca       60

gagacgacgc ctgcagcaag gagaccagga aggggtgaga caaggaagag gatgtctgag      120

ctggagaagg ccatggtggc cctcatcgac gttttccacc aatattctgg aagggaggga      180

gacaagcaca agctgaagaa atccgaactg aaggagctca tcaacaatga gctttcccat      240

ttcttagagg aaatcaaaga gcaggaggtt gtggacaaag tcatggaaac actggacaat      300

gatggagacg gcgaatgtga cttccaggaa ttcatggcct ttgttgccat ggttactact      360

gcctgccacg agttctttga acatgagtga gattagaaag cagccaaacc tttcctgtaa      420

cagagacggt catgcaagaa agcagacagc aagggcttgc agcctagtag gagctgagct      480

ttccagccgt gttgtagcta attaggaagc ttgatttgct ttgtgattga aaaattgaaa      540

acctctttcc aaaggctgtt ttaacggcct gcatcattct ttctgctata ttaggcctgt      600

gtgtaagctg actggcccca gggactcttg ttaacagtaa cttaggagtc aggtctcagt      660

gataaagcgt gcaccgtgca gcccgccatg gccgtgtaga ccctaacccg gagggaaccc      720

tgactacaga aattaccccg gggcaccctt aaaacttcca ctacctttaa aaaacaaagc      780

cttatccagc attatttgaa aacactgctg ttctttaaat gcgttcctca tccatgcaga      840

taacagctgg ttggccggtg tggccctgca agggcgtggt ggcttcggcc tgcttcccgg      900

gatgcgcctg atcaccaggt gaacgctcag cgctggcagc gctcctggaa aaagcaactc      960

catcagaact cgcaatccga gccagctctg ggggctccag cgtggcctcc gtgacccatg     1020

cgattcaagt cgcggctgca ggatccttgc ctccaacgtg cctccagcac atgcggcttc     1080

cgagggcact accgggggct ctgagccacc gcgagggcct gcgttcaata aaaag          1135


<210>  18
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  19
<211>  2151
<212>  DNA
<213>  Homo sapiens

<400>  19
gcctctccaa aggctgcaga agtttcttgc taacaaaaag tccgcacatt cgagcaaaga       60

caggctttag cgagttatta aaaacttagg ggcgctcttg tcccccacag ggcccgaccg      120

cacacagcaa ggcgatggcc cagctgtaag ttggtagcac tgagaactag cagcgcgcgc      180

ggagcccgct gagacttgaa tcaatctggt ctaacggttt cccctaaacc gctaggagcc      240

ctcaatcggc gggacagcag ggcgcgtcct ctgccactct cgctccgagg tccccgcgcc      300

agagacgcag ccgcgctccc accacccaca cccaccgcgc cctcgttcgc ctcttctccg      360

ggagccagtc cgcgccaccg ccgccgccca ggccatcgcc accctccgca gccatgtcca      420

ccaggtccgt gtcctcgtcc tcctaccgca ggatgttcgg cggcccgggc accgcgagcc      480

ggccgagctc cagccggagc tacgtgacta cgtccacccg cacctacagc ctgggcagcg      540

cgctgcgccc cagcaccagc cgcagcctct acgcctcgtc cccgggcggc gtgtatgcca      600

cgcgctcctc tgccgtgcgc ctgcggagca gcgtgcccgg ggtgcggctc ctgcaggact      660

cggtggactt ctcgctggcc gacgccatca acaccgagtt caagaacacc cgcaccaacg      720

agaaggtgga gctgcaggag ctgaatgacc gcttcgccaa ctacatcgac aaggtgcgct      780

tcctggagca gcagaataag atcctgctgg ccgagctcga gcagctcaag ggccaaggca      840

agtcgcgcct gggggacctc tacgaggagg agatgcggga gctgcgccgg caggtggacc      900

agctaaccaa cgacaaagcc cgcgtcgagg tggagcgcga caacctggcc gaggacatca      960

tgcgcctccg ggagaaattg caggaggaga tgcttcagag agaggaagcc gaaaacaccc     1020

tgcaatcttt cagacaggat gttgacaatg cgtctctggc acgtcttgac cttgaacgca     1080

aagtggaatc tttgcaagaa gagattgcct ttttgaagaa actccacgaa gaggaaatcc     1140

aggagctgca ggctcagatt caggaacagc atgtccaaat cgatgtggat gtttccaagc     1200

ctgacctcac ggctgccctg cgtgacgtac gtcagcaata tgaaagtgtg gctgccaaga     1260

acctgcagga ggcagaagaa tggtacaaat ccaagtttgc tgacctctct gaggctgcca     1320

accggaacaa tgacgccctg cgccaggcaa agcaggagtc cactgagtac cggagacagg     1380

tgcagtccct cacctgtgaa gtggatgccc ttaaaggaac caatgagtcc ctggaacgcc     1440

agatgcgtga aatggaagag aactttgccg ttgaagctgc taactaccaa gacactattg     1500

gccgcctgca ggatgagatt cagaatatga aggaggaaat ggctcgtcac cttcgtgaat     1560

accaagacct gctcaatgtt aagatggccc ttgacattga gattgccacc tacaggaagc     1620

tgctggaagg cgaggagagc aggatttctc tgcctcttcc aaacttttcc tccctgaacc     1680

tgagggaaac taatctggat tcactccctc tggttgatac ccactcaaaa aggacacttc     1740

tgattaagac ggttgaaact agagatggac aggttatcaa cgaaacttct cagcatcacg     1800

atgaccttga ataaaaattg cacacactca gtgcagcaat atattaccag caagaataaa     1860

aaagaaatcc atatcttaaa gaaacagctt tcaagtgcct ttctgcagtt tttcaggagc     1920

gcaagataga tttggaatag gaataagctc tagttcttaa caaccgacac tcctacaaga     1980

tttagaaaaa agtttacaac ataatctagt ttacagaaaa atcttgtgct agaatacttt     2040

ttaaaaggta ttttgaatac cattaaaact gctttttttt ttccagcaag tatccaacca     2100

acttggttct gcttcaataa atctttggaa aaactcaaaa aaaaaaaaaa a              2151


<210>  20
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  21
<211>  5216
<212>  DNA
<213>  Homo sapiens

<400>  21
gactcccagc acacagggag ctgcggggca ggcaatgaga gctgcactct ggctggggaa       60

ggcatgagtg acagacccac agcaaggcgg tggggtaagt gtggaccttt gtgtaccaga      120

gagaacatca tggtggcttt caaaggggtc tggactcaag ctttctggaa agcagtcaca      180

gcggaatttc tggccatgct tatttttgtt ctcctcagcc tgggatccac catcaactgg      240

ggtggaacag aaaagccttt accggtcgac atggttctca tctccctttg ctttggactc      300

agcattgcaa ccatggtgca gtgctttggc catatcagcg gtggccacat caaccctgca      360

gtgactgtgg ccatggtgtg caccaggaag atcagcatcg ccaagtctgt cttctacatc      420

gcagcccagt gcctgggggc catcattgga gcaggaatcc tctatctggt cacacctccc      480

agtgtggtgg gaggcctggg agtcaccatg gttcatggaa atcttaccgc tggtcatggt      540

ctcctggttg agttgataat cacatttcaa ttggtgttta ctatctttgc cagctgtgat      600

tccaaacgga ctgatgtcac tggctcaata gctttagcaa ttggattttc tgttgcaatt      660

ggacatttat ttgcaatcaa ttatactggt gccagcatga atcccgcccg atcctttgga      720

cctgcagtta tcatgggaaa ttgggaaaac cattggatat attgggttgg gcccatcata      780

ggagctgtcc tcgctggtgg cctttatgag tatgtcttct gtccagatgt tgaattcaaa      840

cgtcgtttta aagaagcctt cagcaaagct gcccagcaaa caaaaggaag ctacatggag      900

gtggaggaca acaggagtca ggtagagacg gatgacctga ttctaaaacc tggagtggtg      960

catgtgattg acgttgaccg gggagaggag aagaagggga aagaccaatc tggagaggta     1020

ttgtcttcag tatgactaga agatcgcact gaaagcagac aagactcctt agaactgtcc     1080

tcagatttcc ttccacccat taaggaaaca gatttgttat aaattagaaa tgtgcaggtt     1140

tgttgtttca tgtcatatta ctcagtctaa acaataaata tttcataatt tacaaaggag     1200

gaacggaaga aacctattgt gaattccaaa tctaaaaaaa gaaatatttt taaaatgttc     1260

ttaagcaaat atatacctat tttatctagt tacctttcat taacaaccaa ttttaaccgt     1320

gtgtcaagat ttggttaagt cttgcctgac agaactcaaa gacacgtcta tcagcttatt     1380

ccttctctac tggaatattg gtatagtcaa ttcttatttg aatatttatt ctattaaact     1440

gagtttaaca atggcaaaat acagtatgtc acagtcatgc acattcaaga gagaaaatat     1500

aacaagttct tttatgagca atcccttatg catagactac cttggcaaaa gagcattagc     1560

aagtgtcact gctcatcagt tacttccttc catttatatc acaaataccc aagtttcaat     1620

tctaacttca tttcatggta tttcttcctc ctcaatgccc aaggtaatgt gggactaaag     1680

cccagaaatt tgaaaagaat attcagaaat ccttcccaaa tcataagggc acctattgag     1740

attcaagaca agcagactcg taaaatcttg tagaggcaga ggcaaagtta tcatcataca     1800

aaaatcacaa acaaaaagga gatctgtatt cgggtatcaa acggttgatc tgttttcagt     1860

gcacaccctc aaatgcacca caccagtttt acgatctaag cttttaaccc ctttaccact     1920

ttgcttattt ttaaaaaatt tattggcaaa actggggatt ttgtttgtaa ctttggttat     1980

ctatatttaa acattagctg agacatattt ttgataacaa gaacttagct agttgagtcc     2040

tggctttttg ttgattatta agctgtgttc actctagaag gtgtaaaggc cctgtcccaa     2100

tctctgctct ctcacttctc gtgacatttg ttgataatct ttactgcaag tgtaatgata     2160

tttgagtgaa ttaaaatgca tgacagacaa ggtacaacat ggttgcagaa taaaagggtg     2220

aggacatcag atcactctgt attcaaagct tactagacga acaatctttc atttctggat     2280

atattgtagc taacccaaca catttttaaa ctatttttgt tactgactca cttacttgtc     2340

aaaataattg gtttttctgt cctgctttgc cttttgtcac tagaatgttc tccagaaacc     2400

ccagtttctg tcatcttaac tgtctagtct agccgttaac ttagacaaag aagtgcaaat     2460

gtcaatttca ctaaacaaaa gctattagaa gtaaagcaga aacctatcac tgcaaggagt     2520

gacttgtaaa taactgatga tcaagggctg tcttctctca agcatggttc caactctgtg     2580

tcacttttta gcgttaatgg cagttgtgtg tctgtggcag tgagataatg gaccactatt     2640

aaacctgatt ctcttcggtg ctaggaaaga gtgatgtgtg agattcccag agagtcgtca     2700

caccagtgtt atgcctggga gtgccactgg cataccgcag gtgcctaaat cccaggcccc     2760

tttctcaggg ggcgtggcca caccacacac tgcgccagtg acacatagtt acttcctggc     2820

tgggacggca cctatagaaa ctagggtaca aatctcccaa agatggtttg caccgtcatt     2880

tcaaatgttt gcacaatata ccacttagag gcttaaaatc agggtggttc agttcaaaag     2940

gtaatatcaa ccgtcagcaa acatgtcagt ttaaaaataa gttcggttaa caaggaagtg     3000

ttaagcagat tttttgaata cacttacaat atactggctt ataatcattt ttattctgcc     3060

atatggttta tttcatatac actcactttt acactcactt ccaattatag cattcaataa     3120

gttacggtta aagaaaagtg aatggtgttt ttgtaatttg ttttctagta gctagcagag     3180

agcctggcac atagtatgta ttcaaaacaa gtgtgttaat taataaaaat atataaatct     3240

catttgagat ttaagaatat aaataatttt cttttaatct ttattttgct caatatttaa     3300

taggaagtat gatttcaagg actactaaag gaaggcaata tacatgtgaa aaccataaaa     3360

tacatttttt gcattctact atttttaggg gcatgaaatg aatgaaagct ttagcacttt     3420

tttgccccta catatgagac aacatatttt gtatttcact caaggctctg ccagtaaaaa     3480

gtaatgaaat tgtacctttc taatgacatc tatgcagcag gggtctatcg ccttgtggat     3540

ggcaccaaat tatccaagtg tattaggaga ctggggcttt tttctttaat cccttcttat     3600

taatgaagtg catagtgctg ctcccaggag accactgctg acagatacac agagaagaga     3660

tcagagagga aaaactggga agacataaat gaattatacc cagccatgaa acaatgccaa     3720

ctgtctcttc cctaaggaag agtacaagta ccctaaaatt gaaaggtggt ccctacactg     3780

aaaacgcaca tagtttgtca aaagtgtaca aaagggaaag agtcttattt taagctttca     3840

ggctttctta aaaacttggg gaccagaatt tcaatgtatg tttccattgt tgaagataac     3900

attttcttca aagagcctta accttttgta ctggaaggaa atattttctg gacttaagta     3960

gttgcctaaa tttaagattc ctacacttta tttctgccat tgatgctttt cctaaaccct     4020

tatactatct ttttattatc tgagcctttt cctaatgcag ctcataggtg ctagctagag     4080

ctgctgctca gtattgaaga ctttacaagg agattagaaa tctttggaaa acatatgtga     4140

tgaaattgag ctatatgatt tatcagagat ctgattccaa agagcacaga atactgttct     4200

cagaccatga aaccagacaa cacatgtatt ggtttaaact cgataatgac aggaaaattc     4260

caaactagag cagtaaattc aaatggtaag atgaatccta gaaggcctct gattgcagca     4320

tgttgacacc aacctcacgt tacgaacaat tcacagagaa tttgcctttg tggcaactga     4380

agatggaagt ctggggggca cagacaacct tatcaaacaa tataaaagcc aatataaatt     4440

ctcataagca ctatagaatt tgcaaattca gaacatttta tacctaaaag taattctgtc     4500

tttcctaaag tgtttttaac atgaaaatta gtaggaagat gtggttacta tttggaaagt     4560

gtaatgtaac aaaactctct tttgttacca caaattttgt gagtttagta ctctacagat     4620

tgccccataa gagcagtagc ttttgaaact cataattctc tgaaataaat gaaagacatt     4680

taattcaagg atcaaaaatt gtggccatct ttgcaaatga ctacctatag cctgtgaaaa     4740

tacatttcaa aaaatgttat gtgcaatgaa cactaaattt aagagcagtt acagtgtgac     4800

tcactcatgt ttaaaaaaaa tcgaagagct aaaaaatacg tctaatttat gtaacccatt     4860

ggaatgtatt tctaggttct cttcaggatt aattaaataa acatgcaatt tatgaaaaca     4920

tataaacaat tatttatcac ttttatgacc caaatcacaa taaaattgtc atttaggata     4980

aactggggag aatagactga acatatggtt atattcacag ttatttatta acttaaatgt     5040

tattccaaca ttagagctaa tgttaaaaag atttaaactg taacgtctaa tatttggaat     5100

aatatattaa agtattagca ctgtggttga ttttcttgaa ttatgttgca tcttgtacta     5160

ctaagcttgt gaaaataaac atttggatgt tttaaaaggt aaaaaaaaaa aaaaaa         5216


<210>  22
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu 
1               5                   10                  15      


Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln 
            20                  25                  30          


Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe 
        35                  40                  45              


Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys 
    50                  55                  60                  


Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile 
                85                  90                  95      


Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile 
            100                 105                 110         


Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile 
        115                 120                 125             


Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly 
    130                 135                 140                 


Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu 
145                 150                 155                 160 


Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala 
                165                 170                 175     


Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala 
            180                 185                 190         


Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr 
        195                 200                 205             


Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met 
    210                 215                 220                 


Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly 
225                 230                 235                 240 


Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val 
                245                 250                 255     


Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln 
            260                 265                 270         


Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu 
        275                 280                 285             


Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val 
    290                 295                 300                 


Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu 
305                 310                 315                 320 


Ser Ser Val 
            


<210>  23
<211>  11659
<212>  DNA
<213>  Homo sapiens

<400>  23
aggccagaga tttattcgag cttcggcggg ggagggagcg cagctgggcc gcgtttaggc       60

tgcaccaccc gcgtgtttca gccgctcgac tccgctggac ctgggacccc cagacgtggg      120

aggatggggg tgacctagtg tcttccagta gggcaatctc tggacatctt tatctcccca      180

gtacctctcc agatcctgaa gcctggggcc agggaggaga ggttagatgt cagcagtgga      240

aggacagtgc caacaatatg cccaagcagg tggaagtgcg aatgcacgac agtcatcttg      300

gctcagagga acccaagcac cggcacctgg gcctgcgcct gtgtgacaag ctggggaaga      360

atctgctgct caccctgacg gtgtttggtg tcatcctggg agcagtgtgt ggagggcttc      420

ttcgcttggc atctcccatc caccctgatg tggttatgtt aatagccttc ccaggggata      480

tactcatgag gatgctaaaa atgctcattc tccctctaat catctccagc ttaatcacag      540

ggttgtcagg cctggatgct aaggctagtg gccgcttggg cacgagagcc atggtgtatt      600

acatgtccac gaccatcatt gctgcagtac tgggggtcat tctggtcttg gctatccatc      660

caggcaatcc caagctcaag aagcagctgg ggcctgggaa gaagaatgat gaagtgtcca      720

gcctggatgc cttcctggac cttattcgaa atctcttccc tgaaaacctt gtccaagcct      780

gctttcaaca gattcaaaca gtgacgaaga aagtcctggt tgcaccaccg ccggacgagg      840

aggccaacgc aaccagcgct gttgtctctc tgttgaacga gactgtgact gaggtgccgg      900

aggagactaa gatggttatc aagaagggcc tggagttcaa ggatgggatg aacgtcttag      960

gtctgatagg gtttttcatt gcttttggca tcgctatggg gaagatggga gatcaggcca     1020

agctgatggt ggatttcttc aacattttga atgagattgt aatgaagtta gtgatcatga     1080

tcatgtggta ctctcccctg ggtatcgcct gcctgatctg tggaaagatc attgcaatca     1140

aggacttaga agtggttgct aggcaactgg ggatgtacat ggtaacagtg atcataggcc     1200

tcatcatcca cgggggcatc tttctcccct tgatttactt tgtagtgacc aggaaaaacc     1260

ccttctcctt ttttgctggc attttccaag cttggatcac tgccctgggc accgcttcca     1320

gtgctggaac tttgcctgtc acctttcgtt gcctggaaga aaatctgggg attgataagc     1380

gtgtgactag attcgtcctt cctgttggag caaccattaa catggatggt acagcccttt     1440

atgaagcggt agccgccatc tttatagccc aaatgaatgg tgttgtcctg gatggaggac     1500

agattgtgac tgtaagcctc acagccaccc tggcaagcgt cggcgcggcc agtatcccca     1560

gtgccgggct ggtcaccatg ctcctcattc tgacagccgt gggcctgcca acagaggaca     1620

tcagcctgct ggtggctgtg gactggctgc tggacaggat gagaacttca gtcaatgttg     1680

tgggtgactc ttttggggct gggatagtct atcacctctc caagtctgag ctggatacca     1740

ttgactccca gcatcgagtg catgaagata ttgaaatgac caagactcaa tccatttatg     1800

atgacatgaa gaaccacagg gaaagcaact ctaatcaatg tgtctatgct gcacacaact     1860

ctgtcatagt agatgaatgc aaggtaactc tggcagccaa tggaaagtca gccgactgca     1920

gtgttgagga agaaccttgg aaacgtgaga aataaggata tgagtctcag caaattcttg     1980

aataaactcc ccagcgtatc ctatggtaac tgatgatata aacaagcttt ctttaaaaag     2040

gaaaaaaatg cgtatatttc tatgtttact taatctgtta gccgaggctt agaggagctc     2100

ttgtgagtca gtgatgacag gcacggtgct gtgtctttgc caaataatgc tttataaccg     2160

tctaattttc tcacttgtat tattatttga atggatgctg ctggaggaat cagttggaat     2220

tgaagacacg ttcttgccag cttccctttt ctcccaagat gcagaaatgt ggatgctctt     2280

ttcccagggg acatgagtaa agcagtgtgg tacactccag ggacttggga aaatgagcaa     2340

acacacagcg tgttattcct taaagtgttc tccatgtctc gccttgttat gcacaagaga     2400

ttctattaaa agcctctaga agtaactccc cttaaaatgt ctagtaaagc ttgcacatgg     2460

attgattaaa agcaaatacc tgtcttaggg aattctgaca atttatcttc catatgctct     2520

ttaagtaaaa tgtttcaaag acagttttaa agggagccat gctcttaaag gcagttgatt     2580

aaagaacctg ttacatctct gccttaccct gtgtaatctg tgagaacaat ggttgaaatt     2640

tcaaagtatg tttcattatt ctttctaaat ttgataattg attaggaagt attttatata     2700

taaccactgt agatattgac aaaagtaaga gagcacagtc aacataaagt ttaaccagag     2760

ttaaatattc aaatttattt atgttcggtt tgccttcacc tggtgtagta aaatcaaatg     2820

agattatttg gtatgtgttt tgctttgttt aacccaaaag attatttttt ggttcctaaa     2880

gaaaaagata tttttaatct gtcaattatt tcagtcatca tctcatcgtc ctagaaagcc     2940

tggtcatttt actgtcctca cacatggaag acacttgtgt tggctgtgcc tcttttaatg     3000

tcatctcttg atgaaacaaa aatactggta tttatccaat atgttgaaag cgttttgtta     3060

tcttctatca aagcacataa aaccagttat aggacacagt tggaagcaga gccagtcttc     3120

ctcctcagtc ttctcagtag aaaggaacag aaaacaaaca tctgtgcaaa accctataaa     3180

agtgatattc ctatggcaga gtccaggcag ccttgaacaa tgacatggca acaaaggatg     3240

gctctgtaca acttcacaga tggaatcttg tttaaggctg tgaagtttta aggaataaat     3300

aatataattg gtgtagcaca gtgccttgca tgcagtaggc agccaacaaa tccttaatga     3360

ttggtaatgc aagctaaaat ttttaatgtc tctactatcc ttttttattg aataacgcac     3420

agtattttcc taaggttgct gggtttggga gtaagcttgg gacttgaatc attgagaaat     3480

aaagcacatt tgactctaag aagtatgtag aaccttgttt ataggtgaga ataggctgta     3540

ttatatgaaa ccagcggagg gatgctgaga cagtcatggt ttatagaatc caaattctct     3600

gagatgaggg tgcttatgga cctcaaatag cctttcttat ctgctccttg tgacttctct     3660

cttttaaatc agataccttt gaaacataca agagacatga gattccagtt gtttttgtct     3720

cctaaaccct agtgattttt ggataaggat cactactgaa cagtattagg caacttttca     3780

tttttgcttt tcaaatgaca ttggtcttta tttccagtag atgggcagta aacagggtca     3840

gggtggtcaa gggatatgat taagtgtagt agtagaaaat gcattctttt tttttttttt     3900

tttttagaca gagtcttgct ctgttgctca ggctggagta cagtggcacg atctcagctc     3960

actgcactgc aatgtccacc tctctagttc aagcgattct cctgtctcag cctcccgagt     4020

agctgggact acaggcacat gccaccatgc ctggctaatt ttttgtattt ttagtacaga     4080

tgggtttcat tatgttagcc aggatggtct cgatctcctg acctcatgat ccacccgcca     4140

tggcctccca aagtgctggg attacaggcg tgagccaccg tgcccggcca gaaaatacat     4200

tctttacagc aaatgttata ggttaaggag acagttcctg ggtttagctg tgaaactgtt     4260

taggattttc tttaagtggt gttcccaaga gcttttttct ggtaagttgg aggctatagg     4320

caaagcgtct aggagcttgt tgttttttgc tatggaaggc cagctttggg atctatatac     4380

atgggcatgt ttctcaatgg agtggtcaca ggattctctt ctcagaactc tgcctgaaac     4440

ctttccggtg tgttttgtct tcaacttttt cctagctatc ctattagcct gtaaatatgt     4500

cagcagacaa tgtgtttgga agaaacaagg tgtacaactt cacaaagcaa gttttttctg     4560

gtctgagact tactgtgtgc aggaagtctc gtgagaatat acttagaaaa tcacacttat     4620

ctggaaattc aataagtcat attaaaaata tacaatttct tgaactcagg actagcctga     4680

aaatccaaaa tgcatgtaga gttgacatgt tgacatatgt ctatgtcctc tgtttttatt     4740

taagcctcat ttatttctcc cttgccatgc ccatttggga ttttctttgc ccagcatatg     4800

tgccataaac agaacaaatg gatccagggt atacctctaa taacctttat ctaaatagaa     4860

tacatttaac ctgtcaatta tatgtataga tttatcctaa ttggttcaac atatatatga     4920

atgcttgtaa tagtctgtta ctatttgata atgcataaat gttatattta tatacagtta     4980

cagcaggcca gaaacataca tacactgcat cctgtaaggt ctgtaaatca gggcttcggc     5040

aatgccattt tgctatagac tcattcatgt tttttaggaa tcagaatcat ttcaggagaa     5100

aaccaactaa gtagacttta attcttctct ttctcattct tgccctttga gaaacccaag     5160

tggaatcatc acttaattac ttactcaaat tcaatgaatc aaatccaatc caatcagtga     5220

gaagaatagc ttatctttca aggtaatact ttaccttaga tctttgaggg catgcttccc     5280

atacaaagag catcagaaaa tcagggcaat catctagatc tcacagatct tcaacatagg     5340

actctaggtt atgagagctg aaccacatag ctatcagttt cagtttttac ttcctattga     5400

gtgtgtagaa acacagccta tggttttgct gtctgcggaa gttaccatac cctgtaaaag     5460

acaaatattt ctttctcctc tcgaaccact agtcagcctg gatattcatg aaagctgaaa     5520

gaaggggtgc caaaatgcct agctcctgga tttagactca tggaatatga gaaaggctta     5580

gggaaaattc aagtcatggg gagattcctg ctaggtgatg ccaggaatct caatgacctg     5640

ttgattagag ggtctctggt catttccact tgtgtgtgga gaaatacatc atttgcatat     5700

gtatctagtc aagaagccct tttggagcaa agtggttggg aaactcattt actgggtcca     5760

ccaaaggaaa cccaattctg ccatgttttt gcaaatacta cacgtccctt tgctctcaat     5820

agcaaaagtg atgttatagt tttttttact tttgtcagaa tcaaggcttc ggccacctgt     5880

gcaatatttt cccatggaat gcagcagtaa atccaagtag gtatatccgt gctcagagag     5940

aattctccat agttctgact cctgaaaaac aagtctcatt agctctcatc tagtttgatg     6000

actaaaagtg cacagcagtt ataccccagt ggaagtgatt tttctcacct agctgctctc     6060

taactcttac ggctatctag ttgtctgagc tgctggtttg ttttacttat tctccaactg     6120

aactcattcc aaaccaagaa aaaggaccaa atgaaatttt cagttattat catacttgct     6180

ccttgaataa gaatgctaga gtctggaggc agaagaagac taagttaaaa aaaaaacagc     6240

ctgaaggaat tctggagtga gttttgtaag tctaattgtc aaagaagata aatggtctca     6300

gtatctgtag taatttctgg ttaagcctag agggatcact gagtgccaat ccaagcaggt     6360

ggcactagag gcagattgtt ctcctagcat agagtgagtt tccagctgct catgacacat     6420

tttcttatga ttttccctaa aagaaaacca aattttctac tccacctctt cctttcctat     6480

cattccactt attgttgctg ctttgctaac agccagctta gtaagccatc acacaagtta     6540

gtgtgaggct tggttttaaa atagataaca gagaatcttg attaaatagt atccaacttt     6600

gtagcataac acagctaatt caggcaatga catagagatg ataagaaaca acatggtttg     6660

gtagagggaa catttgattt agactctgcc catttttagc tgtatgactt acataagtca     6720

ttttgtgtcc aagcctcatt ttctcccata tgaaaagtga aggggttgga ttaaatgact     6780

aaaatcccct tccagcccta tgagcccaat gtattatgat ctctgctttg tttccttctt     6840

aagaggcttc ctactataaa atgtgaccta tttacatttt aagttgaagt agcccacaat     6900

aatgaataat caatttagat ttttctcatc tcctttggga gaaattaaat tcaagcctct     6960

attcatttga tgttttacaa caagcttcaa agttggccat gttcattcac agtttgatat     7020

tttgagacac caataaaagt tttttaataa aagttccctt gacttaaact caccttccta     7080

atagaagtag tgatttggct cacggaaaaa tgtttccaga gtcaacatga gaggactgga     7140

tgaacctaca gcctcactca agctgttgca tcattgctgc tgtagcaaca gagccctctc     7200

tgaataccca aaacacacaa ttttctccaa caattctaat tgcccaccca gtatgggaat     7260

ttgagagcct ttggtgaata accttgatca ctcttttgaa atttggtaca acacttgcac     7320

aatcacggca actgtttgta aatatctttt cttctccgcc agtatgtaga catgcacacc     7380

cattcacaag taagcccgca aattcatttt cacattttcc tcttggtttg tttttatcat     7440

gggtatcaca ttgcaggaag agatgctcta acttacaaga atggaatttt ctgactatca     7500

ttgccctctt caaggcctga ttagtttgta gggtggatgg gatacaatgc atggtctaca     7560

aggtccatgt caccagccat gatctttaaa caacctcttg cactttctgg cactgctgca     7620

atggcccatg gtggacacct ctgctgtttg tccaaacttc tgctaaatag agtagtgttg     7680

gtatttgttg tgttgtgaac tcctttgttg tcagagaaga cttcagctct tcaggtttgc     7740

aagggcaaga tgtaaagcta ggactgaaag gattgggttt tgtttttcgg ccggcttttt     7800

tccattagtg caaaaaacct gatgcaaggg cagcaagata aacacaattt cttcattgac     7860

ccagataaga acctgtagaa aagtgagaga tgcccctaag ttcctatttc atttatccta     7920

aataatatcc tgaataacta ctgatcagtt tttttctatg tccagccttg cttcactttc     7980

caacctccag gccaaatatt cattttgata ttttacaaaa tccttctggt ttttacacag     8040

ggcccttttg tgctgagaat aaaaccagct attggaacag acctcactgc tttgtagagt     8100

cagaagttga cctagagaat gggtagcaac aggtcctcag tttctctgga gacaccccca     8160

atccttgggt gagtgttgaa acctgacaac tgactgttag ccttgtcatc atcctcactg     8220

gagatggaga tgttgcagtc ggagcctcac tccttctggg gcactgtttc ttctcatggc     8280

aaccattttg cctgcctgga aacagcctgt tgcctttgct agggggcaaa tacacacact     8340

agccaaggaa gttggtccag cacatctctg aggtttctcc cccatggacc catggagcga     8400

attccctgag ataaatgatc agaaagttgg ctgtctggtg gtttaatact ccataagagt     8460

tacttccctt atagaaagtc atcctttggc atctagattt ttctacaaat caccttaact     8520

ccctcccttt ctctttctcc tggaaaacct cagcattgca tctccatgtt gcacaacaca     8580

gatcagatta tctggtcact atagagattt gtatataaaa aaactacttt tttgaggatt     8640

ttgtatattg tttttctatt tgttttctac agcttgagga aagagctggc aaactgtgaa     8700

tctaacttga tcttgttgcc agcagatata ttttggcttc ctggtaagag tctgtgttac     8760

cagggacaat atattgccct ctgatcagta ttgcacccta aatccacaaa ttcctccagc     8820

ccagtcttac atttttttaa acaaatcccc tagcttgttt gctattattt ataaagagca     8880

ttagaaaatg tatttataga cctggatgtt atatgtttaa tattaattta gcctttaata     8940

atgttatagg tttgtaacta ttcttcagaa attataaaga actcagtgta gactgaatta     9000

atctatttag tatctgtaat tttgcagaca tattttctta cagtattttc tatgtaacca     9060

cacatgtaga attataacta attagagcac aagaagtttc ttcagcaatt tagagctacc     9120

aattgtttct tgactatata gtcacatttg acaaatttaa gaacccagtc tttagtgatg     9180

caataaacaa aatgaaccat taagaacaag gaattgctta aatcccttag ctggtgagga     9240

tatacatcta aataattcat ctttctaact caaggaatgg tgctgatttt ttaaatgttt     9300

gacaccaggc cttgtttttc cagctgagca ttctcatttt gcttttctct aagactatca     9360

aagacaaggt attaatagta ggattattcc tagatcagaa tgtttcatac attcctaaag     9420

gtttatgtgg aaattggctt aggaaaactt tgagtagcag agactgagga tgagtgctag     9480

agatgaaatc aggacagatt tgttgcagtt aattcttgcc aagcaaatta gtggtaaatg     9540

tcacattgtt atgtgaattg agcacatatt tttaaagaaa gtttacaaaa aatttttaga     9600

accaactatg aggcaatact gtatcactgg gggctgggag tgggggctta gaatcatact     9660

gaaattgttt aaaagcagcc caggtagttt ctgtcctcag gtgaataaca gactatataa     9720

cttccccgaa aggtaaaacg atagccactg cagagacgag gtgtcttcct tccaccaaat     9780

actttctgag atggtggtag gagtagtatt tttaccgtgg tttaaaaagt agtcagttac     9840

atagaaagtg tattggtatg tatttgaacc tgctcttcat taaacaaaca gattagatgt     9900

accctcgact ggcaataatt gtatctattt tcaagtacag ctagctgtca aagcatgaag     9960

ctcttgtgta tacacactga cacttggttc acgcatgaag aacagtgcct atgcactttg    10020

tgtagctata atgtaggtat ctaggtgtaa tttcagtgaa atggtgtata gatgtattgt    10080

aatttaaatg tatatgttat ttttggctat tcatctaaat gcagtagaca tgttgatcgg    10140

tgttttgcaa acatttcttt ttccttctta gataactagt cgtgaatcat ttctcctctt    10200

tctcagtgtg gcttgggaat atatatgagt gaagaattta tctgtgaatc ctttgtactg    10260

atgattgttt gaaagtctgt gtgtgtccag cacctttgta aatacacaat tcagagcagg    10320

gatgggctgg gtgtgtgtcc tggttcttag tgaaaggtca tctcatgtct gtttaataca    10380

tggtgaatgc aactgtggaa cttttgatta cctagactta ggtaggttta gaatgagaac    10440

atccatctac agtcctcctt tgcttggtgg attgggctca gaggaacaaa aagttagtct    10500

gactctgtgc atattagcat catgtcttta gagaaaggtc agcctctctg gttgccaaat    10560

actcatcatg atgctcatga cttaaaggtt ctgaggagcc ttgtctccct tggatttttg    10620

agtcagggta caggaaaaaa cattgctgac taactaactg caaatgcatc tgcaggtgaa    10680

accctacgaa agcacagttc tggctataaa cttcagagtt ctctgtaaaa aacttagagc    10740

actagaagca caggaatagt gagtgtacag cttatgcggt tgtagagggg caactgatga    10800

acacaggtcc cacatatatg agggagtatg acgttctcta cctaatatgt tctgtgtgca    10860

tgttttgaat gattgaagat gggattaact aatgcaagtt tacagttgcc tcctaaaaca    10920

cacattctgt ataattatcg ctaaatacaa tgctgtgagg tctatagttc ctgtaacccc    10980

tttctcctcc ccaaggacag agaagaacta gccatgtgct atagggaacc ctgagtgccc    11040

tactcttttc ccaagaaggg taaagcctac aatatcatca gggggcatga agcacattaa    11100

tttgcagtgg ctgcttcata tgaggagata tggtggacag gctaattttt ccttgaaaat    11160

gtggcttctt caactccttt caaatttagg atggaatact tcctgaaata aaactgggct    11220

ttatgcagga ttctctttga aaattcttgt atgtccagaa caaaagataa aactaattgt    11280

attcctcaca ttcacaatcc ccattggtct gaagtcacgt agcacagagc atctatagca    11340

catagtgttt aaagactaat gaatgcaaaa agataaaatc ttcaactaat ttttgaattg    11400

tttctcatat atgctactag aaaatgcctt gttgatgaag cacattttgg gtagttgagg    11460

tcttttgttt tcgcctttag ctttctaagc tttcttacaa tgtggactga ttactgtaac    11520

atttcacgtg taaaataact ggatattctt tatatactgg aaataacctg tgaatccaat    11580

atttcactaa gtgttttaac ttttgtgtat atatctctca tcaataaatg tggatttcaa    11640

tttaaaaaaa aaaaaaaaa                                                 11659


<210>  24
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Lys Gln Val Glu Val Arg Met His Asp Ser His Leu Gly Ser 
1               5                   10                  15      


Glu Glu Pro Lys His Arg His Leu Gly Leu Arg Leu Cys Asp Lys Leu 
            20                  25                  30          


Gly Lys Asn Leu Leu Leu Thr Leu Thr Val Phe Gly Val Ile Leu Gly 
        35                  40                  45              


Ala Val Cys Gly Gly Leu Leu Arg Leu Ala Ser Pro Ile His Pro Asp 
    50                  55                  60                  


Val Val Met Leu Ile Ala Phe Pro Gly Asp Ile Leu Met Arg Met Leu 
65                  70                  75                  80  


Lys Met Leu Ile Leu Pro Leu Ile Ile Ser Ser Leu Ile Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Asp Ala Lys Ala Ser Gly Arg Leu Gly Thr Arg Ala Met 
            100                 105                 110         


Val Tyr Tyr Met Ser Thr Thr Ile Ile Ala Ala Val Leu Gly Val Ile 
        115                 120                 125             


Leu Val Leu Ala Ile His Pro Gly Asn Pro Lys Leu Lys Lys Gln Leu 
    130                 135                 140                 


Gly Pro Gly Lys Lys Asn Asp Glu Val Ser Ser Leu Asp Ala Phe Leu 
145                 150                 155                 160 


Asp Leu Ile Arg Asn Leu Phe Pro Glu Asn Leu Val Gln Ala Cys Phe 
                165                 170                 175     


Gln Gln Ile Gln Thr Val Thr Lys Lys Val Leu Val Ala Pro Pro Pro 
            180                 185                 190         


Asp Glu Glu Ala Asn Ala Thr Ser Ala Val Val Ser Leu Leu Asn Glu 
        195                 200                 205             


Thr Val Thr Glu Val Pro Glu Glu Thr Lys Met Val Ile Lys Lys Gly 
    210                 215                 220                 


Leu Glu Phe Lys Asp Gly Met Asn Val Leu Gly Leu Ile Gly Phe Phe 
225                 230                 235                 240 


Ile Ala Phe Gly Ile Ala Met Gly Lys Met Gly Asp Gln Ala Lys Leu 
                245                 250                 255     


Met Val Asp Phe Phe Asn Ile Leu Asn Glu Ile Val Met Lys Leu Val 
            260                 265                 270         


Ile Met Ile Met Trp Tyr Ser Pro Leu Gly Ile Ala Cys Leu Ile Cys 
        275                 280                 285             


Gly Lys Ile Ile Ala Ile Lys Asp Leu Glu Val Val Ala Arg Gln Leu 
    290                 295                 300                 


Gly Met Tyr Met Val Thr Val Ile Ile Gly Leu Ile Ile His Gly Gly 
305                 310                 315                 320 


Ile Phe Leu Pro Leu Ile Tyr Phe Val Val Thr Arg Lys Asn Pro Phe 
                325                 330                 335     


Ser Phe Phe Ala Gly Ile Phe Gln Ala Trp Ile Thr Ala Leu Gly Thr 
            340                 345                 350         


Ala Ser Ser Ala Gly Thr Leu Pro Val Thr Phe Arg Cys Leu Glu Glu 
        355                 360                 365             


Asn Leu Gly Ile Asp Lys Arg Val Thr Arg Phe Val Leu Pro Val Gly 
    370                 375                 380                 


Ala Thr Ile Asn Met Asp Gly Thr Ala Leu Tyr Glu Ala Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ile Ala Gln Met Asn Gly Val Val Leu Asp Gly Gly Gln Ile 
                405                 410                 415     


Val Thr Val Ser Leu Thr Ala Thr Leu Ala Ser Val Gly Ala Ala Ser 
            420                 425                 430         


Ile Pro Ser Ala Gly Leu Val Thr Met Leu Leu Ile Leu Thr Ala Val 
        435                 440                 445             


Gly Leu Pro Thr Glu Asp Ile Ser Leu Leu Val Ala Val Asp Trp Leu 
    450                 455                 460                 


Leu Asp Arg Met Arg Thr Ser Val Asn Val Val Gly Asp Ser Phe Gly 
465                 470                 475                 480 


Ala Gly Ile Val Tyr His Leu Ser Lys Ser Glu Leu Asp Thr Ile Asp 
                485                 490                 495     


Ser Gln His Arg Val His Glu Asp Ile Glu Met Thr Lys Thr Gln Ser 
            500                 505                 510         


Ile Tyr Asp Asp Met Lys Asn His Arg Glu Ser Asn Ser Asn Gln Cys 
        515                 520                 525             


Val Tyr Ala Ala His Asn Ser Val Ile Val Asp Glu Cys Lys Val Thr 
    530                 535                 540                 


Leu Ala Ala Asn Gly Lys Ser Ala Asp Cys Ser Val Glu Glu Glu Pro 
545                 550                 555                 560 


Trp Lys Arg Glu Lys 
                565 


<210>  25
<211>  6969
<212>  DNA
<213>  Homo sapiens

<400>  25
aatattttgt gtgagagcga gcggtgcatt tgcatgttgc ggagtgatta gtgggtttga       60

aaagggaacc gtggctcggc ctcatttccc gctctggttc aggcgcagga ggaagtgttt      120

tgctggagga tgatgacaga ggtcaggctt cgctaatggg ccagtgagga gcggtggagg      180

cgaggccggg cgccggcaca cacacattaa cacacttgag ccatcaccaa tcagcatagg      240

aatctgagaa ttgctctcac acaccaaccc agcaacatcc gtggagaaaa ctctcaccag      300

caactccttt aaaacaccgt catttcaaac cattgtggtc ttcaagcaac aacagcagca      360

caaaaaaccc caaccaaaca aaactcttga cagaagctgt gacaaccaga aaggatgcct      420

cataaagggg gaagacttta actaggggcg cgcagatgtg tgaggccttt tattgtgaga      480

gtggacagac atccgagatt tcagagcccc atattcgagc cccgtggaat cccgcggccc      540

ccagccagag ccagcatgca gaacagtcac agcggagtga atcagctcgg tggtgtcttt      600

gtcaacgggc ggccactgcc ggactccacc cggcagaaga ttgtagagct agctcacagc      660

ggggcccggc cgtgcgacat ttcccgaatt ctgcaggtgt ccaacggatg tgtgagtaaa      720

attctgggca ggtattacga gactggctcc atcagaccca gggcaatcgg tggtagtaaa      780

ccgagagtag cgactccaga agttgtaagc aaaatagccc agtataagcg ggagtgcccg      840

tccatctttg cttgggaaat ccgagacaga ttactgtccg agggggtctg taccaacgat      900

aacataccaa gcgtgtcatc aataaacaga gttcttcgca acctggctag cgaaaagcaa      960

cagatgggcg cagacggcat gtatgataaa ctaaggatgt tgaacgggca gaccggaagc     1020

tggggcaccc gccctggttg gtatccgggg acttcggtgc cagggcaacc tacgcaagat     1080

ggctgccagc aacaggaagg agggggagag aataccaact ccatcagttc caacggagaa     1140

gattcagatg aggctcaaat gcgacttcag ctgaagcgga agctgcaaag aaatagaaca     1200

tcctttaccc aagagcaaat tgaggccctg gagaaagagt ttgagagaac ccattatcca     1260

gatgtgtttg cccgagaaag actagcagcc aaaatagatc tacctgaagc aagaatacag     1320

gtatggtttt ctaatcgaag ggccaaatgg agaagagaag aaaaactgag gaatcagaga     1380

agacaggcca gcaacacacc tagtcatatt cctatcagca gtagtttcag caccagtgtc     1440

taccaaccaa ttccacaacc caccacaccg gtttcctcct tcacatctgg ctccatgttg     1500

ggccgaacag acacagccct cacaaacacc tacagcgctc tgccgcctat gcccagcttc     1560

accatggcaa ataacctgcc tatgcaaccc ccagtcccca gccagacctc ctcatactcc     1620

tgcatgctgc ccaccagccc ttcggtgaat gggcggagtt atgataccta caccccccca     1680

catatgcaga cacacatgaa cagtcagcca atgggcacct cgggcaccac ttcaacagga     1740

ctcatttccc ctggtgtgtc agttccagtt caagttcccg gaagtgaacc tgatatgtct     1800

caatactggc caagattaca gtaaaaaaaa aaaaaaaaaa aaaaaggaaa ggaaatattg     1860

tgttaattca gtcagtgact atggggacac aacagttgag ctttcaggaa agaaagaaaa     1920

atggctgtta gagccgcttc agttctacaa ttgtgtcctg tattgtacca ctggggaagg     1980

aatggacttg aaacaaggac ctttgtatac agaaggcacg atatcagttg gaacaaatct     2040

tcattttggt atccaaactt ttattcattt tggtgtatta tttgtaaatg ggcatttgta     2100

tgttataatg aaaaaaagaa caatgtagac tggatggatg tttgatctgt gttggtcatg     2160

aagttgtttt tttttttttt aaaaagaaaa ccatgatcaa caagctttgc cacgaattta     2220

agagttttat caagatatat cgaatacttc tacccatctg ttcatagttt atggactgat     2280

gttccaagtt tgtatcattc ctttgcatat aattaaacct ggaacaacat gcactagatt     2340

tatgtcagaa atatctgttg gttttccaaa ggttgttaac agatgaagtt tatgtgcaaa     2400

aaagggtaag atataaattc aaggaagaaa aaaagttgat agctaaaagg tagagtgtgt     2460

cttcgatata atccaatttg ttttatgtca aaatgtaagt atttgtcttc cctagaaatc     2520

ctcagaatga tttctataat aaagttaatt tcatttatat ttgacaagaa tatagatgtt     2580

ttatacacat tttcatgcaa tcatacgttt cttttttggc cagcaaaagt taattgttct     2640

tagatatagt tgtattactg ttcacggtcc aatcattttg tgcatctaga gttcattcct     2700

aatcaattaa aagtgcttgc aagagtttta aacttaagtg ttttgaagtt gttcacaact     2760

acatatcaaa attaaccatt gttgattgta aaaaaccatg ccaaagcctt tgtatttcct     2820

ttattataca gttttctttt taaccttata gtgtggtgtt acaaatttta tttccatgtt     2880

agatcaacat tctaaaccaa tggttacttt cacacacact ctgttttaca tcctgatgat     2940

ccttaaaaaa taatccttat agataccata aatcaaaaac gtgttagaaa aaaattccac     3000

ttacagcagg gtgtagatct gtgcccattt atacccacaa catatataca aaatggtaac     3060

atttcccagt tagccattta attctaaagc tcaaagtcta gaaataattt aaaaatgcaa     3120

caagcgatta gctaggaatt gttttttgaa ttaggactgg cattttcaat ctgggcagat     3180

ttccattgtc agcctatttc aacaatgatt tcactgaagt atattcaaaa gtagatttct     3240

taaaggagac tttctgaaag ctgttgcctt tttcaaatag gccctctccc ttttctgtct     3300

ccctcccctt tgcacaagag gcatcatttc ccattgaacc actacagctg ttcccatttg     3360

aatcttgctt tctgtgcggt tgtggatggt tggagggtgg aggggggatg ttgcatgtca     3420

aggaataatg agcacagaca catcaacaga caacaacaaa gcagactgtg actggccggt     3480

gggaattaaa ggccttcagt cattggcagc ttaagccaaa cattcccaaa tctatgaagc     3540

agggcccatt gttggtcagt tgttatttgc aatgaagcac agttctgatc atgtttaaag     3600

tggaggcacg cagggcagga gtgcttgagc ccaagcaaag gatggaaaaa aataagcctt     3660

tgttgggtaa aaaaggactg tctgagactt tcatttgttc tgtgcaacat ataagtcaat     3720

acagataagt cttcctctgc aaacttcact aaaaagcctg ggggttctgg cagtctagat     3780

taaaatgctt gcacatgcag aaacctctgg ggacaaagac acacttccac tgaattatac     3840

tctgctttaa aaaaatcccc aaaagcaaat gatcagaaat gtagaaatta atggaaggat     3900

ttaaacatga ccttctcgtt caatatctac tgttttttag ttaaggaatt acttgtgaac     3960

agataattga gattcattgc tccggcatga aatatactaa taattttatt ccaccagagt     4020

tgctgcacat ttggagacac cttcctaagt tgcagttttt gtatgtgtgc atgtagtttt     4080

gttcagtgtc agcctgcact gcacagcagc acatttctgc aggggagtga gcacacatac     4140

gcactgttgg tacaattgcc ggtgcagaca tttctacctc ctgacatttt gcagcctaca     4200

ttccctgagg gctgtgtgct gagggaactg tcagagaagg gctatgtggg agtgcatgcc     4260

acagctgctg gctggcttac ttcttccttc tcgctggctg taatttccac cacggtcagg     4320

cagccagttc cggcccacgg ttctgttgtg tagacagcag agactttgga gacccggatg     4380

tcgcacgcca ggtgcaagag gtgggaatgg gagaaaagga gtgacgtggg agcggagggt     4440

ctgtatgtgt gcacttgggc acgtatatgt gtgctctgaa ggtcaggatt gccagggcaa     4500

agtagcacag tctggtatag tctgaagaag cggctgctca gctgcagaag ccctctggtc     4560

cggcaggatg ggaacggctg ccttgccttc tgcccacacc ctagggacat gagctgtcct     4620

tccaaacaga gctccaggca ctctcttggg gacagcatgg caggctctgt gtggtagcag     4680

tgcctgggag ttggcctttt actcattgtt gaaataattt ttgtttatta tttatttaac     4740

gatacatata tttatatatt tatcaatggg gtatctgcag ggatgttttg acaccatctt     4800

ccaggatgga gattatttgt gaagacttca gtagaatccc aggactaaac gtctaaattt     4860

tttctccaaa cttgactgac ttgggaaaac caggtgaata gaataagagc tgaatgtttt     4920

aagtaataaa cgttcaaact gctctaagta aaaaaatgca ttttactgca atgaatttct     4980

agaatatttt tcccccaaag ctatgcctcc taacccttaa atggtgaaca actggtttct     5040

tgctacagct cactgccatt tcttcttact atcatcacta ggtttcctaa gattcactca     5100

tacagtatta tttgaagatt cagctttgtt ctgtgaatgt catcttagga ttgtgtctat     5160

attcttttgc ttatttcttt ttactctggg cctctcatac tagtaagatt ttaaaaagcc     5220

ttttcttctc tgtatgtttg gctcaccaag gcgaaatata tattcttctc tttttcattt     5280

ctcaagaata aacctcatct gcttttttgt ttttctgtgt tttggcttgg tactgaatga     5340

ctcaactgct cggttttaaa gttcaaagtg taagtactta gggttagtac tgcttatttc     5400

aataatgttg acggtgacta tctttggaaa gcagtaacat gctgtcttag aaatgacatt     5460

aataatgggc ttaaacaaat gaataggggg gtccccccac tctccttttg tatgcctatg     5520

tgtgtctgat ttgttaaaag atggacaggg aattgattgc agagtgtcgc ttccttctaa     5580

agtagtttta ttttgtctac tgttagtatt taaagatcct ggaggtggac ataaggaata     5640

aatggaagag aaaagtagat attgtatggt ggctactaaa aggaaattca aaaagtctta     5700

gaacccgagc acctgagcaa actgcagtag tcaaaatatt tatctcatgt taaagaaagg     5760

caaatctagt gtaagaaatg agtaccatat agggttttga agttcatata ctagaaacac     5820

ttaaaagata tcatttcaga tattacgttt ggcattgttc ttaagtattt atatctttga     5880

gtcaagctga taattaaaaa aaatctgtta atggagtgta tatttcataa tgtatcaaaa     5940

tggtgtctat acctaaggta gcattattga agagagatat gtttatgtag taagttatta     6000

acataatgag taacaaataa tgtttccaga agaaaggaaa acacattttc agagtgcgtt     6060

tttatcagag gaagacaaaa atacacaccc ctctccagta gcttattttt acaaagccgg     6120

cccagtgaat tagaaaaaca aagcacttgg atatgatttt tggaaagccc aggtacactt     6180

attattcaaa atgcactttt actgagtttg aaaagtttct tttatattta aaataagggt     6240

tcaaatatgc atattcaatt tttatagtag ttatctattt gcaaagcata tattaactag     6300

taattggctg ttaattttat agacatggta gccagggaag tatatcaatg acctattaag     6360

tattttgaca agcaatttac atatctgatg acctcgtatc tctttttcag caagtcaaat     6420

gctatgtaat tgttccattg tgtgttgtat aaaatgaatc aacacggtaa gaaaaaggtt     6480

agagttatta aaataataaa ctgactaaaa tactcatttg aatttattca gaatgttcat     6540

aatgctttca aaggacatag cagagctttt gtggagtatc cgcacaacat tatttattat     6600

ctatggacta aatcaatttt ttgaagttgc tttaaaattt aaaagcacct ttgcttaata     6660

taaagccctt taattttaac tgacagatca attctgaaac tttattttga aaagaaaatg     6720

gggaagaatc tgtgtcttta gaattaaaag aaatgaaaaa aataaacccg acattctaaa     6780

aaaatagaat aagaaacctg atttttagta ctaatgaaat agcgggtgac aaaatagttg     6840

tctttttgat tttgatcaca aaaaataaac tggtagtgac aggatatgat ggagagattt     6900

gacatcctgg caaatcactg tcattgattc aattattcta attctgaata aaagctgtat     6960

acagtaaaa                                                             6969


<210>  26
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  27
<211>  4108
<212>  DNA
<213>  Homo sapiens

<400>  27
ccggccgtct atgctccagg ccctctcctc gcggtgccgg tgaacccgcc agccgccccg       60

atgtacagca tgatgatgga gaccgacctg cactcgcccg gcggcgccca ggcccccacg      120

aacctctcgg gccccgccgg ggcgggcggc ggcgggggcg gaggcggggg cggcggcggc      180

ggcgggggcg ccaaggccaa ccaggaccgg gtcaaacggc ccatgaacgc cttcatggtg      240

tggtcccgcg ggcagcggcg caagatggcc caggagaacc ccaagatgca caactcggag      300

atcagcaagc gcctgggggc cgagtggaag gtcatgtccg aggccgagaa gcggccgttc      360

atcgacgagg ccaagcggct gcgcgcgctg cacatgaagg agcacccgga ttacaagtac      420

cggccgcgcc gcaagaccaa gacgctgctc aagaaggaca agtactcgct ggccggcggg      480

ctcctggcgg ccggcgcggg tggcggcggc gcggctgtgg ccatgggcgt gggcgtgggc      540

gtgggcgcgg cggccgtggg ccagcgcctg gagagcccag gcggcgcggc gggcggcggc      600

tacgcgcacg tcaacggctg ggccaacggc gcctaccccg gctcggtggc ggcggcggcg      660

gcggccgcgg ccatgatgca ggaggcgcag ctggcctacg ggcagcaccc gggcgcgggc      720

ggcgcgcacc cgcacgcgca ccccgcgcac ccgcacccgc accacccgca cgcgcacccg      780

cacaacccgc agcccatgca ccgctacgac atgggcgcgc tgcagtacag ccccatctcc      840

aactcgcagg gctacatgag cgcgtcgccc tcgggctacg gcggcctccc ctacggcgcc      900

gcggccgccg ccgccgccgc tgcgggcggc gcgcaccaga actcggccgt ggcggcggcg      960

gcggcggcgg cggccgcgtc gtcgggcgcc ctgggcgcgc tgggctctct ggtgaagtcg     1020

gagcccagcg gcagcccgcc cgccccagcg cactcgcggg cgccgtgccc cggggacctg     1080

cgcgagatga tcagcatgta cttgcccgcc ggcgaggggg gcgacccggc ggcggcagca     1140

gcggccgcgg cgcagagccg gctgcactcg ctgccgcagc actaccaggg cgcgggcgcg     1200

ggcgtgaacg gcacggtgcc cctgacgcac atctagcgcc ttcgggacgc cggggactct     1260

gcggcggcga cccacgagct cgcggcccgc gcccggctcc cgccccgccc cggcgcggcg     1320

tggcttttgt acagacgttc ccacattctt gtcaaaagga aaatactgga gacgaacgcc     1380

gggtgacgcg tgtcccccac tcaccttccc cggagaccct ggcgaccgcc gggcgctgac     1440

accagacttg ggttttagac tgaacttcgg tgttttcttg agactttttg tacagtattt     1500

atcacctacg gaggaagcgg aaagcgtttt ctttgctcga ggggacaaaa aagtcaaaac     1560

gaggcgagag gcgaagccca cttttgtata ccggccggcg cgctcacttt cctccgcgtt     1620

gcttccggac ggcgccgacc gccggagccc aagtgacgcg gagctcgtcg catttgttat     1680

aaatgtagta aggcaggtcc aagcacttac aagttttttg tagttgttac cgctcttttg     1740

ggttggtttg ttaatttata caaagagatt accaccacca ccccctcctt cagacggcgg     1800

agttatattc tgggttttgt aaaactttat gtatctgagc atttccattt ttttttttgg     1860

gttttgtatt atttcttgta aatgcattgt gaaaaatttt attttcggcg ttgcaatgcg     1920

gggaggagaa gtcagattat gtacatagtt ttctaaaaag cctttcttct aaaaacgaaa     1980

aaagaccccc cacccaaaat gtttcgagtc aacaaattta agagacagag cccattttct     2040

ccataaattt gtaacatgct atttttatgt gcatgtttta tgagttcaaa atgcaatgag     2100

gaaatctgac agggaaatta tctgtatgaa ctaaaagtaa gggaaccccg gggaatggga     2160

ggacaggatt tttcaaggaa cctttttcaa tgaaagagaa ggaagttaaa acctataggt     2220

tattttgtag agctgagtgt taatacgggc cgagaaataa aagtatcttc tgctccggct     2280

gtttcactgc ggacggctgg ggctgctgcg cgttaccttg ctgcaagcgg ggcgccttcc     2340

acctggctgg gggtctgcgc cacagtttgg tccagaggag ggaggaggaa gggaagaccc     2400

cagtggtggg accctggacc aggccatgga tgaaggacaa agaccagggc aggtcacggg     2460

tttcccaatt ccccagcaat taagatttcg agcagaattt atctaaatgt gtttcaagga     2520

aacacaatcg ctgaaccaaa acgtactgca gccgagcccc ctccgtccat cctctgcccc     2580

tccccctggc ttctttctct tgggaaaacg ggcaaaataa ttgtgctgga ttctcacaca     2640

cacagaaata tcgaccatca ccctcccccg cgtgaactgg gatgcaagtt gctaaccgat     2700

gtgaacgcaa aatgccttgt tcattattcc tgacgagatc ttgaggttgt ttgatgcttt     2760

aaatttttta attatattat tttctaggtg tttattggta cattgcagtt ttttttttga     2820

aatttaaaaa tttctgtaaa actttgtctt caagtaatct gacagcatta aatattgcat     2880

ttaaaaatta tactgtagca aatacattta aaaattaatc acaacgttaa gatgaaatta     2940

tatttttgga aaaaaaaaac acttgaagcc cagatggaaa tacgtttatt tcagcagcct     3000

taggtttccc ctcgctttct caacaccctt ccttgtcctg gagtatggac tgtccgtcca     3060

aaagtgagcc tatgctataa gtttaatgag aaccgaattc agcctgcatt cgagaatagc     3120

tttaagtata atgctgatct gacaattgac gtgtaatttg ggaagtcatt ttgataattt     3180

tgcttaaacc actcattcgt taaagtgatt acaaaaaagt tcaagaatga tgtccactgc     3240

tttctaacaa gataataaac cccccccctc ttttcttttt ctttattttt atttctttta     3300

gctatttgat cctttctgaa gcagttgttt ctggaagagt ctgtgcgccc atggatggct     3360

gagcaccact acgacttagt ccgggataag ggcctcccca gtcctctccg ggagatgatt     3420

tgggaaattt tataatgctt gttctgttaa ctcaccggga ccttgagggt ccaatgggac     3480

cttgagggtt ttctctgaaa tatacaaact taaaggactc tctctgaggt tctttgactg     3540

acgtccactc tcagtctggc ccctgtgctc ccctgtgtgt accctggagt ttctgtgtcc     3600

aattgttggc atctaggtct tggctcaaga ttaggatgtg ggccccactt tagaggcaca     3660

gactatgaaa agctgagtta gtgcgcccgg gacgccaggc aagcagcttt tacagtttgg     3720

catcttattg caggtgcttc gtgcacagtc agctgaaata gccaatgcca ggtgctccaa     3780

ccaccttatt tccttgtttt gttgattaga acaacacaga aaaaagcaaa tataaatttt     3840

taatgactcc atttaaaaat atcacagggt gggggcaagg aaattagctg agattcatct     3900

caggattgag attctatccc cccttccccg cccccagcag tgtcgctcca attcaaatta     3960

gtggagaaaa gattacagta ggccctgagc cgactgtgaa ttcggtgctt ggccaaggta     4020

acactcatcg tattcacgga gtgaaatact atatgatgat agttattata ttatatgacg     4080

acttcattca cttcccaaat cacagggt                                        4108


<210>  28
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Tyr Ser Met Met Met Glu Thr Asp Leu His Ser Pro Gly Gly Ala 
1               5                   10                  15      


Gln Ala Pro Thr Asn Leu Ser Gly Pro Ala Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Lys Ala Asn Gln 
        35                  40                  45              


Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly 
    50                  55                  60                  


Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu 
65                  70                  75                  80  


Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Val Met Ser Glu Ala Glu 
                85                  90                  95      


Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met 
            100                 105                 110         


Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr 
        115                 120                 125             


Leu Leu Lys Lys Asp Lys Tyr Ser Leu Ala Gly Gly Leu Leu Ala Ala 
    130                 135                 140                 


Gly Ala Gly Gly Gly Gly Ala Ala Val Ala Met Gly Val Gly Val Gly 
145                 150                 155                 160 


Val Gly Ala Ala Ala Val Gly Gln Arg Leu Glu Ser Pro Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Gly Tyr Ala His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            180                 185                 190         


Pro Gly Ser Val Ala Ala Ala Ala Ala Ala Ala Ala Met Met Gln Glu 
        195                 200                 205             


Ala Gln Leu Ala Tyr Gly Gln His Pro Gly Ala Gly Gly Ala His Pro 
    210                 215                 220                 


His Ala His Pro Ala His Pro His Pro His His Pro His Ala His Pro 
225                 230                 235                 240 


His Asn Pro Gln Pro Met His Arg Tyr Asp Met Gly Ala Leu Gln Tyr 
                245                 250                 255     


Ser Pro Ile Ser Asn Ser Gln Gly Tyr Met Ser Ala Ser Pro Ser Gly 
            260                 265                 270         


Tyr Gly Gly Leu Pro Tyr Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Gly Ala His Gln Asn Ser Ala Val Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Gly Ala Leu Gly Ala Leu Gly Ser Leu Val Lys Ser 
305                 310                 315                 320 


Glu Pro Ser Gly Ser Pro Pro Ala Pro Ala His Ser Arg Ala Pro Cys 
                325                 330                 335     


Pro Gly Asp Leu Arg Glu Met Ile Ser Met Tyr Leu Pro Ala Gly Glu 
            340                 345                 350         


Gly Gly Asp Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Arg Leu 
        355                 360                 365             


His Ser Leu Pro Gln His Tyr Gln Gly Ala Gly Ala Gly Val Asn Gly 
    370                 375                 380                 


Thr Val Pro Leu Thr His Ile 
385                 390     


<210>  29
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  29
ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga       60

gtgtttgcaa aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga      120

agaggagaga gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa      180

taataataac aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt      240

tgatcctgat tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt      300

tcctcgcgga gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg      360

cccgcgggcc ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc      420

ccgcgcacag cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc      480

agcaaacttc ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga      540

aaaacagccc ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc      600

agcggcgcaa gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc      660

tgggcgccga gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta      720

agcggctgcg agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga      780

aaaccaagac gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg      840

gcggcaatag catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc      900

agcgcatgga cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc      960

aggaccagct gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc     1020

agcccatgca ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga     1080

cctacatgaa cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca     1140

tggctcttgg ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg     1200

ttacctcttc ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca     1260

gcatgtatct ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt     1320

cccagcacta ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct     1380

cacacatgtg agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag     1440

ggaaatggga ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc     1500

tcaaaaagaa aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag     1560

agaacaccaa tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat     1620

gagagagatc ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg     1680

gtggggaggg cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac     1740

tttttaaaag ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc     1800

aataatattt agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac     1860

ttttgtacag tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg     1920

agaatttgcc aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa     1980

atttaggaca gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg     2040

tttaaaaatt gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc     2100

ttgtttaaaa agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc     2160

aaaaatggcc atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa     2220

ctttccattt tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta     2280

tggtttgtaa tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt     2340

ccgtagttgt attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc     2400

atgtatatat ttgaactaat atcatcctta taacaggtac attttcaact taagttttta     2460

ctccattatg cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa     2520


<210>  30
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  31
<211>  2055
<212>  DNA
<213>  Homo sapiens

<400>  31
ttcattataa atctagagac tccaggattt taacgttctg ctggactgag ctggttgcct       60

catgttatta tgcaggcaac tcactttatc ccaatttctt gatacttttc cttctggagg      120

tcctatttct ctaacatctt ccagaaaagt cttaaagctg ccttaacctt ttttccagtc      180

cacctcttaa attttttcct cctcttcctc tatactaaca tgagtgtgga tccagcttgt      240

ccccaaagct tgccttgctt tgaagcatcc gactgtaaag aatcttcacc tatgcctgtg      300

atttgtgggc ctgaagaaaa ctatccatcc ttgcaaatgt cttctgctga gatgcctcac      360

acggagactg tctctcctct tccttcctcc atggatctgc ttattcagga cagccctgat      420

tcttccacca gtcccaaagg caaacaaccc acttctgcag agaagagtgt cgcaaaaaag      480

gaagacaagg tcccggtcaa gaaacagaag accagaactg tgttctcttc cacccagctg      540

tgtgtactca atgatagatt tcagagacag aaatacctca gcctccagca gatgcaagaa      600

ctctccaaca tcctgaacct cagctacaaa caggtgaaga cctggttcca gaaccagaga      660

atgaaatcta agaggtggca gaaaaacaac tggccgaaga atagcaatgg tgtgacgcag      720

ggatgcctgg tgaacccgac tgggaacctt ccaatgtgga gcaaccagac ctggaacaat      780

tcaacctgga gcaaccagac ccagaacatc cagtcctgga gcaaccactc ctggaacact      840

cagacctggt gcacccaatc ctggaacaat caggcctgga acagtccctt ctataactgt      900

ggagaggaat ctctgcagtc ctgcatgcag ttccagccaa attctcctgc cagtgacttg      960

gaggctgcct tggaagctgc tggggaaggc cttaatgtaa tacagcagac cactaggtat     1020

tttagtactc cacaaaccat ggatttattc ctaaactact ccatgaacat gcaacctgaa     1080

gacgtgtgaa gatgagtgaa actgatatta ctcaatttca gtctggacac tggctgaatc     1140

cttcctctcc cctcctccca tccctcatag gatttttctt gtttggaaac cacgtgttct     1200

ggtttccatg atgcccatcc agtcaatctc atggagggtg gagtatggtt ggagcctaat     1260

cagcgaggtt tctttttttt tttttttcct attggatctt cctggagaaa atactttttt     1320

tttttttttt tttgaaacgg agtcttgctc tgtcgcccag gctggagtgc agtggcgcgg     1380

tcttggctca ctgcaagctc cgtctcccgg gttcacgcca ttctcctgcc tcagcctccc     1440

gagcagctgg gactacaggc gcccgccacc tcgcccggct aatattttgt atttttagta     1500

gagacggggt ttcactgtgt tagccaggat ggtctcgatc tcctgacctt gtgatccacc     1560

cgcctcggcc tccctaacag ctgggattta caggcgtgag ccaccgcgcc ctgcctagaa     1620

aagacatttt aataaccttg gctgccgtct ctggctatag ataagtagat ctaatactag     1680

tttggatatc tttagggttt agaatctaac ctcaagaata agaaatacaa gtacaaattg     1740

gtgatgaaga tgtattcgta ttgtttggga ttgggaggct ttgcttattt tttaaaaact     1800

attgaggtaa agggttaagc tgtaacatac ttaattgatt tcttaccgtt tttggctctg     1860

ttttgctata tcccctaatt tgttggttgt gctaatcttt gtagaaagag gtctcgtatt     1920

tgctgcatcg taatgacatg agtactgctt tagttggttt aagttcaaat gaatgaaaca     1980

actatttttc ctttagttga ttttaccctg atttcaccga gtgtttcaat gagtaaatat     2040

acagcttaaa cataa                                                      2055


<210>  32
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  33
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  33
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc       60

gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc      120

ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt      180

ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg      240

cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg      300

accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc      360

tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt      420

atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga      480

tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg      540

ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg      600

cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg      660

ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac      720

cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc      780

tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct      840

tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc      900

ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc      960

accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc     1020

agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg     1080

gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg     1140

gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag     1200

ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt     1260

ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac     1320

ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg     1380

gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc     1440

tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca     1500

cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag     1560

gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc     1620

cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg     1680

ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag     1740

aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc     1800

tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt     1860

gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa     1920

ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac     1980

cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca     2040

gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg     2100

tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa     2160

ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa     2220

agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat     2280

attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa     2340

ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa     2400

tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt     2460

tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg     2520

cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc     2580

atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg     2640

taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt     2700

ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa     2760

tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt     2820

ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg     2880

catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  34
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Gly Gln 
        355                 360                 365             


Ser Arg Gly Phe Val Ala Arg Ala Gly Glu Pro Cys Val Cys Trp Pro 
    370                 375                 380                 


His Phe Gly Thr His Gly Met Met Leu Thr Pro Pro Ser Ser Pro Leu 
385                 390                 395                 400 


Glu Leu Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys 
                405                 410                 415     


Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys 
            420                 425                 430         


Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys 
        435                 440                 445             


Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp 
    450                 455                 460                 


Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His 
465                 470                 475                 480 


Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp 
                485                 490                 495     


Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His 
            500                 505                 510         


Phe 
    


<210>  35
<211>  4014
<212>  DNA
<213>  Homo sapiens

<400>  35
gtgcggggga agatgtagca gcttcttctc cgaaccaacc ctttgccttc ggacttctcc       60

ggggccagca gccgcccgac caggggcccg gggccacggg ctcagccgac gaccatgggc      120

tccgtgtcca accagcagtt tgcaggtggc tgcgccaagg cggcagaaga ggcgcccgag      180

gaggcgccgg aggacgcggc ccgggcggcg gacgagcctc agctgctgca cggtgcgggc      240

atctgtaagt ggttcaacgt gcgcatgggg ttcggcttcc tgtccatgac cgcccgcgcc      300

ggggtcgcgc tcgacccccc agtggatgtc tttgtgcacc agagtaagct gcacatggaa      360

gggttccgga gcttgaagga gggtgaggca gtggagttca cctttaagaa gtcagccaag      420

ggtctggaat ccatccgtgt caccggacct ggtggagtat tctgtattgg gagtgagagg      480

cggccaaaag gaaagagcat gcagaagcgc agatcaaaag gagacaggtg ctacaactgt      540

ggaggtctag atcatcatgc caaggaatgc aagctgccac cccagcccaa gaagtgccac      600

ttctgccaga gcatcagcca tatggtagcc tcatgtccgc tgaaggccca gcagggccct      660

agtgcacagg gaaagccaac ctactttcga gaggaagaag aagaaatcca cagccctacc      720

ctgctcccgg aggcacagaa ttgagccaca atgggtgggg gctattcttt tgctatcagg      780

aagttttgag gagcaggcag agtggagaaa gtgggaatag ggtgcattgg ggctagttgg      840

cactgccatg tatctcaggc ttgggttcac accatcaccc tttcttccct ctaggtgggg      900

ggaaagggtg agtcaaagga actccaacca tgctctgtcc aaatgcaagt gagggttctg      960

ggggcaacca ggagggggga atcaccctac aacctgcata ctttgagtct ccatccccag     1020

aatttccagc ttttgaaagt ggcctggata gggaagttgt tttcctttta aagaaggata     1080

tataataatt cccatgccag agtgaaatga ttaagtataa gaccagattc atggagccaa     1140

gccactacat tctgtggaag gagatctctc aggagtaagc attgtttttt tttcacatct     1200

tgtatcctca tacccacttt tgggataggg tgctggcagc tgtcccaagc aatgggtaat     1260

gatgatggca aaaagggtgt ttgggggaac agctgcagac ctgctgctct atgctcaccc     1320

ccgccccatt ctgggccaat gtgattttat ttatttgctc ccttggatac tgcaccttgg     1380

gtcccacttt ctccaggatg ccaactgcac tagctgtgtg cgaatgacgt atcttgtgca     1440

ttttaacttt ttttccttaa tataaatatt ctggttttgt atttttgtat attttaatct     1500

aaggccctca tttcctgcac tgtgttctca ggtacatgag caatctcagg gatagccagc     1560

agcagctcca ggtctgcgca gcaggaatta ctttttgttg tttttgccac cgtggagagc     1620

aactatttgg agtgcacagc ctattgaact acctcatttt tgccaataag agctggcttt     1680

tctgccatag tgtcctcttg aaaccccctc tgccttgaaa atgttttatg ggagactagg     1740

ttttaactgg gtggccccat gacttgattg ccttctactg gaagattggg aattagtcta     1800

aacaggaaat ggtggtacac agaggctagg agaggctggg cccggtgaaa aggccagaga     1860

gcaagccaag attaggtgag ggttgtctaa tcctatggca caggacgtgc tttacatctc     1920

cagatctgtt cttcaccaga ttaggttagg cctaccatgt gccacagggt gtgtgtgtgt     1980

ttgtaaaact agagttgcta aggataagtt taaagaccaa tacccctgta cttaatcctg     2040

tgctgtcgag ggatggatat atgaagtaag gtgagatcct taacctttca aaattttcgg     2100

gttccaggga gacacacaag cgagggtttt gtggtgcctg gagcctgtgt cctgccctgc     2160

tacagtagtg attaatagtg tcatggtagc taaaggagaa aaagggggtt tcgtttacac     2220

gctgtgagat caccgcaaac ctaccttact gtgttgaaac gggacaaatg caatagaacg     2280

cattgggtgg tgtgtgtctg atcctgggtt cttgtctccc ctaaatgctg ccccccaagt     2340

tactgtattt gtctgggctt tgtaggactt cactacgttg attgctaggt ggcctagttt     2400

gtgtaaatat aatgtattgg tctttctccg tgttctttgg gggttttgtt tacaaacttc     2460

tttttgtatt gagagaaaaa tagccaaagc atctttgaca gaaggttctg caccaggcaa     2520

aaagatctga aacattagtt tggggggccc tcttcttaaa gtggggatct tgaaccatcc     2580

tttcttttgt attccccttc ccctattacc tattagacca gatcttctgt cctaaaaact     2640

tgtcttctac cctgccctct tttctgttca cccccaaaag aaaacttaca cacccacaca     2700

catacacatt tcatgcttgg agtgtctcca caactcttaa atgatgtatg caaaaatact     2760

gaagctagga aaaccctcca tcccttgttc ccaacctcct aagtcaagac cattaccatt     2820

tctttctttc tttttttttt ttttttaaaa tggagtctca ctgtgtcacc caggctggag     2880

tgcagtggca tgatcggctc actgcagcct ctgcctcttg ggttcaagtg attctcctgc     2940

ctcagcctcc tgagtagctg ggatttcagg cacccgccac actcagctaa tttttgtatt     3000

tttagtagag acggggtttc accatgttgt ccaggctggt ctggaactcc tgacctcagg     3060

tgatctgccc accttggctt cccaaagtgc tgggattaca ggcatgagcc accatgctgg     3120

gccaaccatt tcttggtgta ttcatgccaa acacttaaga cactgctgta gcccaggcgc     3180

ggtggctcac acctgtaatc ccagcacttt ggaaggctga ggcgggcgga tcacaaggtc     3240

acgagttcaa aactatcctg gccaacacag tgaaaccccg tctctactaa aatacaaaaa     3300

aattagccgg gtgtggtggt gcatgccttt agtcctagct attcaggagg ctgaggcagg     3360

ggaatcgctt gaacccgaga ggcagaggtt gcagtgagct gagatcgcac cactgcactc     3420

cagcctggtt acagagcaag actctgtctc aaacaaaaca aaacaaaaca aaaacacact     3480

actgtatttt ggatggatca aacctcctta attttaattt ctaatcctaa agtaaagaga     3540

tgcaattggg ggccttccat gtagaaagtg gggtcaggag gccaagaaag ggaatatgaa     3600

tgtatatcca agtcactcag gaacttttat gcaggtgcta gaaactttat gtcaaagtgg     3660

ccacaagatt gtttaatagg agacgaacga atgtaactcc atgtttactg ctaaaaacca     3720

aagctttgtg taaaatcttg aatttatggg gcgggagggt aggaaagcct gtacctgtct     3780

gtttttttcc tgatcctttt ccctcattcc tgaactgcag gagactgagc ccctttgggc     3840

tttggtgacc ccatcactgg ggtgtgttta tttgatggtt gattttgctg tactgggtac     3900

ttcctttccc attttctaat cattttttaa cacaagctga ctcttccctt cccttctcct     3960

ttccctggga aaatacaatg aataaataaa gacttattgg tacgcaaact gtca           4014


<210>  36
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ser Val Ser Asn Gln Gln Phe Ala Gly Gly Cys Ala Lys Ala 
1               5                   10                  15      


Ala Glu Glu Ala Pro Glu Glu Ala Pro Glu Asp Ala Ala Arg Ala Ala 
            20                  25                  30          


Asp Glu Pro Gln Leu Leu His Gly Ala Gly Ile Cys Lys Trp Phe Asn 
        35                  40                  45              


Val Arg Met Gly Phe Gly Phe Leu Ser Met Thr Ala Arg Ala Gly Val 
    50                  55                  60                  


Ala Leu Asp Pro Pro Val Asp Val Phe Val His Gln Ser Lys Leu His 
65                  70                  75                  80  


Met Glu Gly Phe Arg Ser Leu Lys Glu Gly Glu Ala Val Glu Phe Thr 
                85                  90                  95      


Phe Lys Lys Ser Ala Lys Gly Leu Glu Ser Ile Arg Val Thr Gly Pro 
            100                 105                 110         


Gly Gly Val Phe Cys Ile Gly Ser Glu Arg Arg Pro Lys Gly Lys Ser 
        115                 120                 125             


Met Gln Lys Arg Arg Ser Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly 
    130                 135                 140                 


Leu Asp His His Ala Lys Glu Cys Lys Leu Pro Pro Gln Pro Lys Lys 
145                 150                 155                 160 


Cys His Phe Cys Gln Ser Ile Ser His Met Val Ala Ser Cys Pro Leu 
                165                 170                 175     


Lys Ala Gln Gln Gly Pro Ser Ala Gln Gly Lys Pro Thr Tyr Phe Arg 
            180                 185                 190         


Glu Glu Glu Glu Glu Ile His Ser Pro Thr Leu Leu Pro Glu Ala Gln 
        195                 200                 205             


Asn 
    


<210>  37
<211>  1589
<212>  DNA
<213>  Homo sapiens

<400>  37
ggaaaaaagg aaagtgcact tggaagagat ccaagtgggc aacttgaaga acaagtgcca       60

aatagcactt ctgtcatgct ggatgtcagg gctctttgtc cactttgtat agccgctggc      120

ttatagaagg tgctcgataa atctcttgaa tttaaaaatc aattaggatg cctctatagt      180

gaaaaagata cagtaaagat gagggataat caatttaaaa aatgagtaag tacacacaaa      240

gcactttatc cattcttatg acacctgtta cttttttgct gtgtttgtgt gtatgcatgc      300

catgttatag tttgtgggac cctcaaagca agctggggag agtatatact gaatttagct      360

tctgagacat gatgctcttc ctttttaatt aacccagaac ttagcagctt atctatttct      420

ctaatctcaa aacatcctta aactgggggt gatacttgag tgagagaatt ttgcaggtat      480

taaatgaact atcttctttt ttttttttct ttgagacaga gtcttgctct gtcacccagg      540

ctggagtgca gtggcgtgat ctcagctcac tgcaacctcc gcctcccggg ttcaagtgat      600

tctcctgcct cagcctcctg agtagctggg attacagtcc caggacatca aagctctgca      660

gaaagaactc gagcaatttg ccaagctcct gaagcagaag aggatcaccc tgggatatac      720

acaggccgat gtggggctca ccctgggggt tctatttggg aaggtattca gccaaacgac      780

catctgccgc tttgaggctc tgcagcttag cttcaagaac atgtgtaagc tgcggccctt      840

gctgcagaag tgggtggagg aagctgacaa caatgaaaat cttcaggaga tatgcaaagc      900

agaaaccctc gtgcaggccc gaaagagaaa gcgaaccagt atcgagaacc gagtgagagg      960

caacctggag aatttgttcc tgcagtgccc gaaacccaca ctgcagcaga tcagccacat     1020

cgcccagcag cttgggctcg agaaggatgt ggtccgagtg tggttctgta accggcgcca     1080

gaagggcaag cgatcaagca gcgactatgc acaacgagag gattttgagg ctgctgggtc     1140

tcctttctca gggggaccag tgtcctttcc tctggcccca gggccccatt ttggtacccc     1200

aggctatggg agccctcact tcactgcact gtactcctcg gtccctttcc ctgaggggga     1260

agcctttccc cctgtctccg tcaccactct gggctctccc atgcattcaa actgaggtgc     1320

ctgcccttct aggaatgggg gacaggggga ggggaggagc tagggaaaga aaacctggag     1380

tttgtgccag ggtttttggg attaagttct tcattcacta aggaaggaat tgggaacaca     1440

aagggtgggg gcaggggagt ttggggcaac tggttggagg gaaggtgaag ttcaatgatg     1500

ctcttgattt taatcccaca tcatgtatca cttttttctt aaataaagaa gcctgggaca     1560

cagtagatag acacacttaa aaaaaaaaa                                       1589


<210>  38
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  39
<211>  2379
<212>  DNA
<213>  Homo sapiens

<400>  39
gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc       60

ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag      120

ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc      180

cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag      240

agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg      300

gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa      360

ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac      420

gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc      480

caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg      540

gtagtggaaa accagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg      600

aactatgacc tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac      660

ttctaccagc agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg      720

aagaaattcg agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc      780

tcgccctcct acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc      840

gggagcttct ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg      900

gtgaaccaga gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc      960

caggactgta tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc     1020

tcctaccagg ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc     1080

tgctccacct ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac     1140

ccctcggtgg tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg     1200

caagactcca gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc     1260

ccgcagggca gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc     1320

gactctgagg aggaacaaga agatgaggaa gaaatcgatg ttgtttctgt ggaaaagagg     1380

caggctcctg gcaaaaggtc agagtctgga tcaccttctg ctggaggcca cagcaaacct     1440

cctcacagcc cactggtcct caagaggtgc cacgtctcca cacatcagca caactacgca     1500

gcgcctccct ccactcggaa ggactatcct gctgccaaga gggtcaagtt ggacagtgtc     1560

agagtcctga gacagatcag caacaaccga aaatgcacca gccccaggtc ctcggacacc     1620

gaggagaatg tcaagaggcg aacacacaac gtcttggagc gccagaggag gaacgagcta     1680

aaacggagct tttttgccct gcgtgaccag atcccggagt tggaaaacaa tgaaaaggcc     1740

cccaaggtag ttatccttaa aaaagccaca gcatacatcc tgtccgtcca agcagaggag     1800

caaaagctca tttctgaaga ggacttgttg cggaaacgac gagaacagtt gaaacacaaa     1860

cttgaacagc tacggaactc ttgtgcgtaa ggaaaagtaa ggaaaacgat tccttctaac     1920

agaaatgtcc tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc     1980

acaaccttgg ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt     2040

ggactttggg cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat     2100

ttgtatttaa gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata     2160

ttgccattaa atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat     2220

cctagtatat agtacctagt attataggta ctataaaccc taattttttt tatttaagta     2280

cattttgctt tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc     2340

aaatatatca ttgagccaaa tcttaaaaaa aaaaaaaaa                            2379


<210>  40
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH primer

<400>  41
gtggacctga cctgccgtct                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gapdh primer

<400>  42
ggaggagtgg gtgtcgctgt                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oct4 primer

<400>  43
cctcacttca ctgcactgta                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oct4 primer

<400>  44
caggttttct ttccctagct                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nanog primer

<400>  45
tgaacctcag ctacaaacag                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nanog primer

<400>  46
tggtggtagg aagagtaaag                                                   20


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2 primer

<400>  47
cccagcagac ttcacatgt                                                    19


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2 primer

<400>  48
cctcccattt ccctcgtttt                                                   20


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ki67 primer

<400>  49
atacgtgaac aggagccag                                                    19


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ki67 primer

<400>  50
ccttggaatc ttgagctttc tc                                                22


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX1 primer

<400>  51
aattttattt tcggcgttgc                                                   20


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX1 primer

<400>  52
tgggctctgt ctcttaaatt tgt                                               23


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nestin primer

<400>  53
ctggagcagg agaaacagg                                                    19


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nestin primer

<400>  54
tgggagcaaa gatccaagac                                                   20


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX6 primer

<400>  55
atgtgtgagt aaaattctgg gca                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX6 primer

<400>  56
gcttacaact tctggagtcg cta                                               23


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFAP primer

<400>  57
ctgctcaatg tcaagctgg                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFAP primer

<400>  58
aatggtgatc cggttctcc                                                    19


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAP2 primer

<400>  59
ggagacagag atgagaattc ct                                                22


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Map2 primer

<400>  60
gaattggctc tgacctggt                                                    19


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TH primer

<400>  61
gtgctaaacc tgctcttctc                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TH primer

<400>  62
ttcaaacgtc tcaaacacct                                                   20


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABA primer

<400>  63
caacaactgc tacagggac                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
gagaagatgg caaacccag                                                    19


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glutamate transporter primer

<400>  65
ccatgactaa gcacaagact c                                                 21


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glutamate transporter primer

<400>  66
agatgacacc tccatagtgc                                                   20


<210>  67
<211>  5977
<212>  DNA
<213>  Homo sapiens

<400>  67
tgtctctctt acctccttga tgttcggcac tatttgtggc cggcgtggtg gaaggacaca       60

gtgaggttct cacccccgcc ccccgctcct cgctcccatc ccagttccat caaaacgaac      120

ccgggccagc gcaaggatct ccgagttgcg agtgtgctga ggctgggact gtcactcatt      180

ctccgatcag cgcgtgaacg cagctcggct gccgctggca ggaaacaatt ctgcaaaaat      240

aatcatactc agcctggcaa ttgtctgccc ctaggtctgt cgctcagccg ccgtccacac      300

tcgctgcagg ggggggggca cagaatttac cgcggcaaga acatccctcc cagccagcag      360

attacaatgc tgcaaactaa ggatctcatc tggactttgt ttttcctggg aactgcagtt      420

tctctgcagg tggatattgt tcccagccag ggggagatca gcgttggaga gtccaaattc      480

ttcttatgcc aagtggcagg agatgccaaa gataaagaca tctcctggtt ctcccccaat      540

ggagaaaagc tcaccccaaa ccagcagcgg atctcagtgg tgtggaatga tgattcctcc      600

tccaccctca ccatctataa cgccaacatc gacgacgccg gcatttacaa gtgtgtggtt      660

acaggcgagg atggcagtga gtcagaggcc accgtcaacg tgaagatctt tcagaagctc      720

atgttcaaga atgcgccaac cccacaggag ttccgggagg gggaagatgc cgtgattgtg      780

tgtgatgtgg tcagctccct cccaccaacc atcatctgga aacacaaagg ccgagatgtc      840

atcctgaaaa aagatgtccg attcatagtc ctgtccaaca actacctgca gatccggggc      900

atcaagaaaa cagatgaggg cacttatcgc tgtgagggca gaatcctggc acggggggag      960

atcaacttca aggacattca ggtcattgtg aatgtgccac ctaccatcca ggccaggcag     1020

aatattgtga atgccaccgc caacctcggc cagtccgtca ccctggtgtg cgatgccgaa     1080

ggcttcccag agcccaccat gagctggaca aaggatgggg aacagataga gcaagaggaa     1140

gacgatgaga agtacatctt cagcgacgat agttcccagc tgaccatcaa aaaggtggat     1200

aagaacgacg aggctgagta catctgcatt gctgagaaca aggctggcga gcaggatgcg     1260

accatccacc tcaaagtctt tgcaaaaccc aaaatcacat atgtagagaa ccagactgcc     1320

atggaattag aggagcaggt cactcttacc tgtgaagcct ccggagaccc cattccctcc     1380

atcacctgga ggacttctac ccggaacatc agcagcgaag aaaagactct ggatgggcac     1440

atggtggtgc gtagccatgc ccgtgtgtcg tcgctgaccc tgaagagcat ccagtacact     1500

gatgccggag agtacatctg caccgccagc aacaccatcg gccaggactc ccagtccatg     1560

taccttgaag tgcaatatgc cccaaagcta cagggccctg tggctgtgta cacttgggag     1620

gggaaccagg tgaacatcac ctgcgaggta tttgcctatc ccagtgccac gatctcatgg     1680

tttcgggatg gccagctgct gccaagctcc aattacagca atatcaagat ctacaacacc     1740

ccctctgcca gctatctgga ggtgacccca gactctgaga atgattttgg gaactacaac     1800

tgtactgcag tgaaccgcat tgggcaggag tccttggaat tcatccttgt tcaagcagac     1860

accccctctt caccatccat cgaccaggtg gagccatact ccagcacagc ccaggtgcag     1920

tttgatgaac cagaggccac aggtggggtg cccatcctca aatacaaagc tgagtggaga     1980

gcagttggtg aagaagtatg gcattccaag tggtatgatg ccaaggaagc cagcatggag     2040

ggcatcgtca ccatcgtggg cctgaagccc gaaacaacgt acgccgtaag gctggcggcg     2100

ctcaatggca aagggctggg tgagatcagc gcggcctccg agttcaagac gcagccagtc     2160

caaggggaac ccagtgcacc taagctcgaa gggcagatgg gagaggatgg aaactctatt     2220

aaagtgaacc tgatcaagca ggatgacggc ggctccccca tcagacacta tctggtcagg     2280

taccgagcgc tctcctccga gtggaaacca gagatcaggc tcccgtctgg cagtgaccac     2340

gtcatgctga agtccctgga ctggaatgct gagtatgagg tctacgtggt ggctgagaac     2400

cagcaaggaa aatccaaggc ggctcatttt gtgttcagga cctcggccca gcccacagcc     2460

atcccagcca acggcagccc cacctcaggc ctgagcaccg gggccatcgt gggcatcctc     2520

atcgtcatct tcgtcctgct cctggtggtt gtggacatca cctgctactt cctgaacaag     2580

tgtggcctgt tcatgtgcat tgcggtcaac ctgtgtggaa aagccgggcc cggggccaag     2640

ggcaaggaca tggaggaggg caaggccgcc ttctcgaaag atgagtccaa ggagcccatc     2700

gtggaggttc gaacggagga ggagaggacc ccaaaccatg atggagggaa acacacagag     2760

cccaacgaga ccacgccact gacggagccc gagaagggcc ccgtagaagc aaagccagag     2820

tgccaggaga cagaaacgaa gccagcgcca gccgaagtca agacggtccc caatgacgcc     2880

acacagacaa aggagaacga gagcaaagca tgatgggtga agagaaccga gcaaagatca     2940

aaataaaaag tgacacagca gcttcaccag agcatttcca acaccacaga cacacacacg     3000

cacgcacaca cacaaacaca catgcacaca cacacatctc atttctctag tgtcttttgc     3060

ctttaaaaaa aactaaacag ataaaacatg ggaatctcct ttttgtaggt ttatagaaag     3120

ggtccctttg ttgcacactc acttgtaaga aaatgagaca aaaaggttaa acccacagcc     3180

aaactaggac actccgttcc ctgaaaccgt taaaaaatca aacaaaagga ccccaaatta     3240

agaatctagg aagctcagaa acgaaatcta ggttcaggaa gaccacactt ggtgttaccc     3300

gattggcaca gaccagtttc agagaaatac tttcaggcac taagactaat cgaatgaaca     3360

aagtccacag tttattttta tactttcagt caagtttgaa ctctgtaaaa cctcataaat     3420

aagttataat ttctgttcac tttgtatttg ttcagtatgc aaagtgtgtc accctttcta     3480

gctgaattca attcccacgt agactcttat tttataggac gaatgccaaa ttgcagcttc     3540

tgggggtaga tctcaatttg cagtattcag acttcttttt ctttctttta cattcttttt     3600

tctttctttc tttctgccaa ctttgttttc cagtgtttac aaggtgacaa atgtttgact     3660

ttggttgtgt ttaaatgtcc gtgtaaaata gctgcctttt attttttaag gtaacaaata     3720

ccacctagag gtaggtagga tcatcccacg cttgctttag cacaggacaa ctttacaaaa     3780

catgattgtt tacagctgct cttcccctct tttctgatct gcagtttttg cctgggtccc     3840

actcaggtga aaatccatct cattctggaa tggttttgct tttgaatttt tggttatttt     3900

tgtgtttctt tgggggttag accactttct gattagccgc cacctgcctg catctgtgaa     3960

aagggatctg ctcccaggcg ttctcaccct tcttttgaag gactccttag gctttgttga     4020

atgaagcaga gaagattgta tagttggggc tggtcttggt gaacacacat tattacccca     4080

cacatcccct ttgtgtagaa agccaaataa aatctataca taccatttcc ttttgagccc     4140

agaatctaga tttgagcgga agagcatgtg tgcttcaggg aattagtgtc tttttttgga     4200

aatctgttga agtaaagtaa catcggcctt ctgttcactt aggcagcatt tatagaaaca     4260

aaagaagaaa gaaacaacct actgtctgga gtcataacac aactttcctg gattggaaac     4320

caagtggggg aaaaaataca gaaactttaa gggggatggg agggggggga gaagggaaaa     4380

gccagccctt tgtatagaaa ttttgctttt ttttccctca ttctacttta gaactgcaag     4440

cttgtgcact gtggatgcgt gaatatttta gtgtgaaacg tgtttttgtc atagtattga     4500

aataaaactt caacatagtt tggttgtgga aggtatagca gatagttcag aaaaaatatt     4560

caggaaacaa aaatcactca aacggaatcg aagcctttta acaaagaaaa tgaaatacag     4620

atgatgatga tgatgatgaa gatgatgcta agtaaacaga aatcagtact ccgcatgcgc     4680

tcctctccta aggtacaaag cagcaagagg ttagggtggc aaggctgcct ctgggtccat     4740

tctgtgggcc actctcccca acgttctgac acttctgcag tctgatcagt ggcgatgcta     4800

gattataatt tcaaactgtg aagaataatg gtcttgtcat ttgctcaatg tggggttatg     4860

ttgcattttc tcagctcctg gggatggaaa tggaggatcc cagaacacac agccctggcc     4920

cctttgattc tagggcctgc acagatctct ggttcaaatg cacaggccct cagaatagag     4980

gaacatgaag agagatctta gagcacacag tagaatgtga gagcctgggt gtctgagacc     5040

gggagggccc agcagtgagg ggcaggctct tctggtcacc aggctgttca gtggactcag     5100

ttcttcatct tgtaatgtcg atggctttgc cacaccaggc caagcccatg ccataccttg     5160

tcaagactgt caaagtggtt gtggttaggt caaactggtt ttggttctga tggttaggaa     5220

gaaacaggtc agccctcaga tcacctggcc cgggacagct gaccccctag aaccctggct     5280

ctgccattag ctaggaccta agactctgcc cacattttgg tctgttctct cccattacac     5340

ataggtttgt ctcagcatgc aagagttttt cctttaaaaa aaaaaaaaaa aaaaaaaaaa     5400

aagcaatgct ttctctaaaa tcaaagaggg agtcatttta ttccaagatg ttttatcttt     5460

tatgttaaga gatcaaagct tataattttc ttttttaatt tttgaaggag ggatcaactc     5520

cagtttccaa tgtctatgtg tctatgtgtg tatgtgccat acatatgtat tcacatgaag     5580

accggcatgg ccaagttctg ctggaggagc actcaagtgt gacgagcagg gccactggac     5640

cctgcagggc tgtggtgtat atagtgcagc tttggaggtg gaactctatt ttcacacttt     5700

tctatggagc cttccgagtc ccaggttttc acttgaggct gtctgtctgg atggcggttt     5760

tcagacctcc attaacatcc ctacccagca ttctgtactt cgggggcctt ctctcttgtt     5820

ataaaacttt ttaccaagtg aaacatcgat accacctttg tttccattct cactggtgta     5880

aatactgagt actaactgag aattttgact ttgcattctg tcggaatact tgtgttcaat     5940

aaaaattgaa agaaaaaagc taaaaaaaaa aaaaaaa                              5977


<210>  68
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  69
<211>  5591
<212>  DNA
<213>  Homo sapiens

<400>  69
gctactccca ccccgccccg ccccgtcatt gtccccgtcg gtctcttttc tcttccgtcc       60

taaaagctct gcgagccgct cccttctccc ggtgccccgc gtctgtccat cctcagtggg      120

tcagacgagc aggatggagg gctgcatggg ggaggagtcg tttcagatgt gggagctcaa      180

tcggcgcctg gaggcctacc tggcccgggt caaggcgctg gaggagcaga atgagctgct      240

cagcgcggag ctcggggggc tccgggcaca atccgcggac acctcctggc gggcgcatgc      300

cgacgacgag ctggcggccc tgcgggccct cgttgaccaa cgctggcggg agaagcacgc      360

ggccgaggtg gcgcgcgaca acctggctga agagctggag ggcgtggcag gccgatgcca      420

gcagctgcgg ctggcccggg agcggacgac ggaggaggta gcccgcaacc ggcgcgccgt      480

cgaggcagag aaatgcgccc gggcctggct gagtagccag gtggcagagc tggagcgcga      540

gctagaggct ctacgcgtgg cgcacgagga ggagcgcgtc ggcctgaacg cgcaggctgc      600

ctgtgccccc cgctgccccg cgccgccccg cgggcctccc gcgccggccc cggaggtaga      660

ggagctggca aggcgactgg gcgaggcgtg gcgcggggca gtgcgcggct accaggagcg      720

cgtggcacac atggagacgt cgctgggcca ggcccgcgag cggctgggcc gggcggtgca      780

gggtgcccgc gagggccgcc tggagctgca gcagctccag gctgagcgcg gaggcctcct      840

ggagcgcagg gcagcgttgg aacagaggtt ggagggccgc tggcaggagc ggctgcgggc      900

tactgaaaag ttccagctgg ctgtggaggc cctggagcag gagaaacagg gcctacagag      960

ccagatcgct caggtcctgg aaggtcggca gcagctggcg cacctcaaga tgtccctcag     1020

cctggaggtg gccacgtaca ggaccctcct ggaggctgag aactcccggc tgcaaacacc     1080

tggcggtggc tccaagactt ccctcagctt tcaggacccc aagctggagc tgcaattccc     1140

taggacccca gagggccggc gtcttggatc tttgctccca gtcctgagcc caacttccct     1200

cccctcaccc ttgcctgcta cccttgagac acctgtgcca gcctttctta agaaccaaga     1260

attcctccag gcccgtaccc ctaccttggc cagcaccccc atccccccca cacctcaggc     1320

accctctcct gctgtagatg cagagatcag agcccaggat gctcctctct ctctgctcca     1380

gacacagggt gggaggaaac aggctccaga gcccctgcgg gctgaagcca gggtggccat     1440

tcctgccagc gtcctgcctg gaccagagga gcctgggggc cagcggcaag aggccagtac     1500

aggccagtcc ccagaggacc atgcctcctt ggcaccaccc ctcagccctg accactccag     1560

tttagaggct aaggatggag aatccggtgg gtctagagtg ttcagcatat gccgagggga     1620

aggtgaaggg caaatctggg ggttggtaga gaaagaaaca gccatagagg gcaaagtggt     1680

aagcagcttg cagcaggaaa tatgggaaga agaggatcta aacaggaagg aaatccagga     1740

ctcccaggtt cctttggaaa aagaaaccct gaagtctctg ggagaggaga ttcaagagtc     1800

actgaagact ctggaaaacc agagccatga gacactagaa agggagaatc aagaatgtcc     1860

gaggtcttta gaagaagact tagaaacact aaaaagtcta gaaaaggaaa ataaagagct     1920

attaaaggat gtggaggtag tgagacctct agaaaaagag gctgtaggcc aacttaagcc     1980

tacaggaaaa gaggacacac agacattgca atccctgcaa aaggagaatc aagaactaat     2040

gaaatctctt gaaggtaatc tagagacatt tttatttcca ggaacggaaa atcaagaatt     2100

agtaagttct ctgcaagaga acttagagtc attgacagct ctggaaaagg agaatcaaga     2160

gccactgaga tctccagaag taggggatga ggaggcactg agacctctga caaaggagaa     2220

tcaggaaccc ctgaggtctc ttgaagatga gaacaaagag gcctttagat ctctagaaaa     2280

agagaaccag gagccactga agactctaga agaagaggac cagagtattg tgagacctct     2340

agaaacagag aatcacaaat cactgaggtc tttagaagaa caggaccaag agacattgag     2400

aactcttgaa aaagagactc aacagcgacg gaggtctcta ggggaacagg atcagatgac     2460

attaagaccc ccagaaaaag tggatctaga accactgaag tctcttgacc aggagatagc     2520

tagacctctt gaaaatgaga atcaagagtt cttaaagtca ctcaaagaag agagcgtaga     2580

ggcagtaaaa tctttagaaa cagagatcct agaatcactg aagtctgcgg gacaagagaa     2640

cctggaaaca ctgaaatctc cagaaactca agcaccactg tggactccag aagaaataaa     2700

tcagggggca atgaatcctc tagaaaagga aattcaagaa ccactggagt ctgtggaagt     2760

gaaccaagag acattcagac tcctggaaga ggagaatcag gaatcattga gatctctggg     2820

agcatggaac ctggagaatt tgagatctcc agaggaggta gacaaggaaa gtcaaaggaa     2880

tctggaagag gaagagaacc tgggaaaggg agagtaccaa gagtcactga ggtctctgga     2940

ggaggaggga caggagctgc cgcagtctgc agatgtgcag aggtgggaag atacggtgga     3000

gaaggaccaa gaactggctc aggaaagccc tcctgggatg gctggagtgg aaaatgagga     3060

tgaggcagag ctgaatctga gggagcagga tggcttcact gggaaggagg aggtggtaga     3120

gcagggagag ctgaatgcca cagaggaggt ctggatccca ggcgaggggc acccagagag     3180

ccctgagccc aaagagcaga gaggcctggt tgagggagcc agtgtgaagg gaggggctga     3240

gggcctccag gaccctgaag ggcaatcaca acaggtgggg gccccaggcc tccaggctcc     3300

ccaggggctg ccagaggcga tagagcccct ggtggaagat gatgtggccc cagggggtga     3360

ccaagcctcc ccagaggtca tgttggggtc agagcctgcc atgggtgagt ctgctgcggg     3420

agctgagcca ggcccggggc agggggtggg agggctgggg gacccaggcc atctgaccag     3480

ggaagaggtg atggaaccac ccctggaaga ggagagtttg gaggcaaaga gggttcaggg     3540

cttggaaggg cctagaaagg acctagagga ggcaggtggt ctggggacag agttctccga     3600

gctgcctggg aagagcagag acccttggga gcctcccagg gagggtaggg aggagtcaga     3660

ggctgaggcc cccaggggag cagaggaggc gttccctgct gagaccctgg gccacactgg     3720

aagtgatgcc ccttcacctt ggcctctggg gtcagaggaa gctgaggagg atgtaccacc     3780

agtgctggtc tcccccagcc caacgtacac cccgatcctg gaagatgccc ctgggcctca     3840

gcctcaggct gaagggagtc aggaggctag ctggggggtg caggggaggg ctgaagccct     3900

ggggaaagta gagagcgagc aggaggagtt gggttctggg gagatccccg agggccccca     3960

ggaggaaggg gaggagagca gagaagagag cgaggaggat gagctcgggg agacccttcc     4020

agactccact cccctgggct tctacctcag gtcccccacc tcccccaggt gggaccccac     4080

tggagagcag aggccacccc ctcaagggga gactggaaag gagggctggg atcctgctgt     4140

cctggcttcc gagggccttg aggccccacc ctcagaaaag gaggaggggg aggagggaga     4200

agaggagtgt ggccgtgact ctgacctgtc agaagaattt gaggacctgg ggactgaggc     4260

accttttctt cctggggtcc ctggggaggt ggcagaacct ctgggccagg tgccccagct     4320

gctactggat cctgcagcct gggatcgaga tggggagtcc gatgggtttg cagatgagga     4380

agaaagtggg gaggagggag aggaggatca ggaggagggg agggagccag gggctgggcg     4440

gtgggggcca gggtcttctg ttggcagcct ccaggccctg agtagctccc agagagggga     4500

attcctggag tctgattctg tgagtgtcag tgtcccctgg gatgacagct tgaggggtgc     4560

agtggctggt gcccccaaga ctgccctgga aacggagtcc caggacagtg ctgagccttc     4620

tggctcagag gaagagtctg accctgtttc cttggagagg gaggacaaag tccctggccc     4680

tctagagatc cccagtggga tggaggatgc aggcccaggg gcagacatca ttggtgttaa     4740

tggccagggt cccaacttgg aggggaagtc acagcatgtg aatgggggag tgatgaacgg     4800

gctggagcag tctgaggaag tggggcaagg aatgccgcta gtctctgagg gagaccgagg     4860

gagccccttt caggaggagg aggggagtgc tctgaagacc tcttgggcag gggctcctgt     4920

tcacctgggc cagggtcagt tcctgaagtt cactcagagg gaaggagata gagagtcctg     4980

gtcctcaggg gaggactagg aaaagaccat ctgcccggca ctggggactt aggggtgcgg     5040

ggaggggaag gacgcctcca agcccgctcc ctgctcagga gcagcactct taacttacga     5100

tctcttgaca tatggtttct ggctgagagg cctggcccgc taaggtgaaa aggggtgtgg     5160

caaaggagcc tactccaaga atggaggctg taggaatata acctcccacc ctgcaaaggg     5220

aatctcttgc ctgctccatc tcataggcta agtcagctga atcccgatag tactaggtcc     5280

ccttccctcc gcatcccgtc agctggaaaa ggcctgtggc ccagaggctt ctccaaaggg     5340

agggtgacat gctggctttt gtgcccaagc tcaccagccc tgcgccacct cactgcagta     5400

gtgcaccatc tcactgcagt agcacgccct cctgggccgt ctggcctgtg gctaatggag     5460

gtgacggcac tcccatgtgc tgactccccc catccctgcc acgctgtggc cctgcctggc     5520

tagtccctgc ctgaataaag taatgcctcc gcttcaaaaa aaaaaaaaaa aaaaaaaaaa     5580

aaaaaaaaaa a                                                          5591


<210>  70
<211>  1621
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu 
            580                 585                 590         


Asn Lys Glu Leu Leu Lys Asp Val Glu Val Val Arg Pro Leu Glu Lys 
        595                 600                 605             


Glu Ala Val Gly Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr 
    610                 615                 620                 


Leu Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu 
625                 630                 635                 640 


Gly Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu 
                645                 650                 655     


Val Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys 
            660                 665                 670         


Glu Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala 
        675                 680                 685             


Leu Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu 
    690                 695                 700                 


Asp Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu 
705                 710                 715                 720 


Pro Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu 
                725                 730                 735     


Glu Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln 
            740                 745                 750         


Glu Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser 
        755                 760                 765             


Leu Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp 
    770                 775                 780                 


Leu Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu 
785                 790                 795                 800 


Asn Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu 
                805                 810                 815     


Ala Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala 
            820                 825                 830         


Gly Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro 
        835                 840                 845             


Leu Trp Thr Pro Glu Glu Ile Asn Gln Gly Ala Met Asn Pro Leu Glu 
    850                 855                 860                 


Lys Glu Ile Gln Glu Pro Leu Glu Ser Val Glu Val Asn Gln Glu Thr 
865                 870                 875                 880 


Phe Arg Leu Leu Glu Glu Glu Asn Gln Glu Ser Leu Arg Ser Leu Gly 
                885                 890                 895     


Ala Trp Asn Leu Glu Asn Leu Arg Ser Pro Glu Glu Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Glu Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Ile 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Ser Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Ala  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Pro Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Pro  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Leu Gly Lys Val Glu  Ser Glu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Gly Ser Gly Glu  Ile Pro Glu Gly Pro  Gln Glu Glu 
    1265                 1270                 1275             


Gly Glu  Glu Ser Arg Glu Glu  Ser Glu Glu Asp Glu  Leu Gly Glu 
    1280                 1285                 1290             


Thr Leu  Pro Asp Ser Thr Pro  Leu Gly Phe Tyr Leu  Arg Ser Pro 
    1295                 1300                 1305             


Thr Ser  Pro Arg Trp Asp Pro  Thr Gly Glu Gln Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gln Gly  Glu Thr Gly Lys Glu  Gly Trp Asp Pro Ala  Val Leu Ala 
    1325                 1330                 1335             


Ser Glu  Gly Leu Glu Ala Pro  Pro Ser Glu Lys Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Gly  Glu Glu Glu Cys Gly  Arg Asp Ser Asp Leu  Ser Glu Glu 
    1355                 1360                 1365             


Phe Glu  Asp Leu Gly Thr Glu  Ala Pro Phe Leu Pro  Gly Val Pro 
    1370                 1375                 1380             


Gly Glu  Val Ala Glu Pro Leu  Gly Gln Val Pro Gln  Leu Leu Leu 
    1385                 1390                 1395             


Asp Pro  Ala Ala Trp Asp Arg  Asp Gly Glu Ser Asp  Gly Phe Ala 
    1400                 1405                 1410             


Asp Glu  Glu Glu Ser Gly Glu  Glu Gly Glu Glu Asp  Gln Glu Glu 
    1415                 1420                 1425             


Gly Arg  Glu Pro Gly Ala Gly  Arg Trp Gly Pro Gly  Ser Ser Val 
    1430                 1435                 1440             


Gly Ser  Leu Gln Ala Leu Ser  Ser Ser Gln Arg Gly  Glu Phe Leu 
    1445                 1450                 1455             


Glu Ser  Asp Ser Val Ser Val  Ser Val Pro Trp Asp  Asp Ser Leu 
    1460                 1465                 1470             


Arg Gly  Ala Val Ala Gly Ala  Pro Lys Thr Ala Leu  Glu Thr Glu 
    1475                 1480                 1485             


Ser Gln  Asp Ser Ala Glu Pro  Ser Gly Ser Glu Glu  Glu Ser Asp 
    1490                 1495                 1500             


Pro Val  Ser Leu Glu Arg Glu  Asp Lys Val Pro Gly  Pro Leu Glu 
    1505                 1510                 1515             


Ile Pro  Ser Gly Met Glu Asp  Ala Gly Pro Gly Ala  Asp Ile Ile 
    1520                 1525                 1530             


Gly Val  Asn Gly Gln Gly Pro  Asn Leu Glu Gly Lys  Ser Gln His 
    1535                 1540                 1545             


Val Asn  Gly Gly Val Met Asn  Gly Leu Glu Gln Ser  Glu Glu Val 
    1550                 1555                 1560             


Gly Gln  Gly Met Pro Leu Val  Ser Glu Gly Asp Arg  Gly Ser Pro 
    1565                 1570                 1575             


Phe Gln  Glu Glu Glu Gly Ser  Ala Leu Lys Thr Ser  Trp Ala Gly 
    1580                 1585                 1590             


Ala Pro  Val His Leu Gly Gln  Gly Gln Phe Leu Lys  Phe Thr Gln 
    1595                 1600                 1605             


Arg Glu  Gly Asp Arg Glu Ser  Trp Ser Ser Gly Glu  Asp 
    1610                 1615                 1620     


