                         SEQUENCE LISTING

<110>  UCB BIOPHARMA SPRL
 
<120>  ANTIBODY MOLECULES WHICH BIND CD45

<130>  PF0061

<160>  215   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 formula


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is F or V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is S, G or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is G, S or N

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is W or Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is I or M

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is C, S or Y

<400>  1

Gly Xaa Ser Phe Ser Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10      


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 formula


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be amino acid C or S

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be amino acid T, I or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be amino acid A or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid R or S

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be amino acid N or S

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be amino acid V or A

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be amino acid N or K

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be amino acid G, A, S or T

<400>  2

Xaa Xaa Tyr Xaa Gly Xaa Ser Gly Ser Thr Tyr Tyr Ala Xaa Trp Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 formula


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be amino acid G, A or D

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be amino acid N, S or L

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be amino acid A or G

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be amino acid G, W or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be amino acid V, T or E

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid I or absent

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid D or absent

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be amino acid G, S, A, T or Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be amino acid Y, V or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be amino acid G or M

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid G, A or D

<400>  3

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu 
1               5                   10          


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 formula


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid I, F or V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid S or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be amino acid N or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be amino acid W, L or N

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be amino acid N or absent

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid N, S, Q or absent

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be amino acid N  or A

<400>  4

Gln Ala Ser Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 formula


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be amino acid Q, G or D

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be amino acid K, N or D

<400>  5

Xaa Ala Ser Xaa Leu Ala Ser 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 formula VI


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be amino acid Q or  absent

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be amino acid S or L

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be amino acid S or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be amino acid Y, G or absent

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be amino acid D or Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid G, A, T, S or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid G or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be amino acid N, S, Y or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be amino acid V, A or W

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid F or Y or absent

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be amino acid F or absent

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be amino acid N, A or absent

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 formula Ia


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid S, G or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid G, S or N

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be amino acid W or Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be amino acid I or M

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid C, S or Y

<400>  7

Gly Phe Ser Phe Ser Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 formula Ib


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid S, G or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid G, S or N

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid C, S or Y

<400>  8

Gly Phe Ser Phe Ser Xaa Xaa Tyr Trp Ile Xaa 
1               5                   10      


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 formula VIa


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be amino acid Y, A or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be amino acid G, A, T, S or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be amino acid G or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be amino acid N, S, Y or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be amino acid V, A or W

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be amino acid F or Y or absent

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be amino acid F or absent

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be amino acid N, A or absent

<400>  9

Gln Ser Xaa Tyr Asp Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  10

Gly Phe Ser Phe Ser Ala Gly Tyr Trp Ile Cys 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  11

Gly Phe Ser Phe Ser Ala Gly Tyr Trp Ile Ser 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  12

Gly Phe Ser Phe Ser Ala Gly Tyr Trp Ile Cys 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  13

Gly Phe Ser Phe Ser Ala Gly Tyr Trp Ile Ser 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  14

Gly Val Ser Phe Ser Ser Ser Tyr Trp Ile Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  15

Gly Phe Ser Phe Ser Gly Asn Tyr Tyr Met Cys 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  16

Gly Phe Ser Phe Ser Gly Asn Tyr Tyr Met Ser 
1               5                   10      


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  17

Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Gly 
        


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  18

Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Ala 
        


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  19

Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Ser 
        


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  20

Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Thr 
        


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  21

Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Gly 
        


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  22

Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Ala 
        


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  23

Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Ser 
        


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  24

Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Thr 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  25

Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  26

Ser Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  27

Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  28

Ser Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  29

Cys Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  30

Ser Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  31

Gly Asn Ala Gly Val Ala Val Gly Ala Leu 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  32

Gly Asn Ala Gly Val Ala Val Gly Ala Leu 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  33

Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu 
1               5                   10  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  34

Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  35

Asp Leu Gly Tyr Glu Ile Asp Ser Tyr Gly Gly Leu 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  36

Asp Leu Gly Tyr Glu Ile Asp Ala Tyr Gly Gly Leu 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  37

Asp Leu Gly Tyr Glu Ile Asp Thr Tyr Gly Gly Leu 
1               5                   10          


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  38

Gln Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  39

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ser 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  40

Gln Ala Ser Gln Ser Phe Tyr Asn Leu Leu Ala 
1               5                   10      


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  41

Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn Asn Leu Ser 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  42

Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn Ser Leu Ser 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  43

Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn Gln Leu Ser 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  44

Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn Asn Leu Ala 
1               5                   10              


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  45

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  46

Gly Ala Ser Asn Leu Ala Ser 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  47

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  48

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  49

Gln Ser Tyr Tyr Asp Ser Gly Ser Asn Val Phe Phe Ala 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  50

Gln Ser Tyr Tyr Asp Ala Gly Ser Asn Val Phe Phe Ala 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  51

Gln Ser Tyr Tyr Asp Thr Gly Ser Asn Val Phe Phe Ala 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  52

Gln Ser Tyr Tyr Asp Ser Gly Ser Ser Val Phe Phe Asn 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  53

Gln Ser Tyr Tyr Asp Ala Gly Ser Ser Val Phe Phe Asn 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  54

Gln Ser Tyr Tyr Asp Thr Gly Ser Ser Val Phe Phe Asn 
1               5                   10              


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  55

Gln Ser Ala Asp Gly Ser Ser Tyr Ala 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  56

Gln Ser Ala Asp Ser Ser Ser Tyr Ala 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  57

Gln Ser Ala Asp Ala Ser Ser Tyr Ala 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  58

Gln Ser Ala Asp Thr Ser Ser Tyr Ala 
1               5                   


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  59

Leu Gly Gly Tyr Tyr Ser Ser Gly Trp Tyr Phe Ala 
1               5                   10          


<210>  60
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4122 VL region

<400>  60

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Met Cys Gln Ala Ser Gln Ser Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Ser Gly Ser 
                85                  90                  95      


Asn Val Phe Phe Ala Phe Gly Gly Gly Thr Lys Val Val Val Glu 
            100                 105                 110     


<210>  61
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4122 VL region

<400>  61
gacattgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcatgtgcc aggccagtca gagcattagc aattggttag cctggtatca acagaaacca      120

gggcagcctc ccaagctcct gatctaccag gcatccaaac tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tattatgata gtggtagtaa tgtttttttt      300

gctttcggcg gagggaccaa ggtggtggtc gaa                                   333


<210>  62
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4122 VH region

<400>  62

Leu Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly Tyr 
            20                  25                  30          


Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Pro Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Ser Gly Ala Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4122 VH region

<400>  63
ctgtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatccct gacactcacc       60

tgcacagcct ctggattctc cttcagtgcc ggctattgga tatgttgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcatgc acttatgctg gtcgtagtgg tagcacttac      180

tacgcgaact gggtgaatgg ccgattcacc atccccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgtc aggcgcggac acggccagct atttctgtgc gagaggtaat      300

gctggtgttg ctgttggtgc cttgtggggc ccaggcaccc tggtcaccgt ctcgagt         357


<210>  64
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4122 gL1 V-region - IGKV1-5 framework

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Ser Gly Ser 
                85                  90                  95      


Asn Val Phe Phe Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4122 gH6 V-region - IGHV3-7 framework

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4122 gH4 V-region - IGHV3-7 framework

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  67
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4122 gH3 V-region - IGHV2-70 framework

<400>  67

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  68
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4122 gH5 V-region - IGHV2-70 framework

<400>  68

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Thr Tyr Ala Gly Arg Ser Gly Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  69
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4129 VL region

<400>  69

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Ser Gly Ser 
                85                  90                  95      


Ser Val Phe Phe Asn Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110     


<210>  70
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4129 VL region

<400>  70
gacattgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaattgcc aagccagtca gagcattagc agttggttat cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatggt gcatccaatc tggcatctgg ggtcccatca      180

cggttcagcg gcagtggatc tgggacacag ttcagtctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tattatgata gtggtagtag tgtttttttt      300

aatttcggcg gagggaccaa ggtggtcgtc aaa                                   333


<210>  71
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4129 VH region

<400>  71

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly Tyr 
            20                  25                  30          


Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Pro Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Gly Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4129 VH region

<400>  72
cagtcgttgg aggagtccgg gggagacctg gttaagcctg gggcatccct gacactcacc       60

tgcacagcct ctggattctc cttcagtgcc ggctattgga tatgttgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcatgc atttatgctg gtagtagtgg tagcacttac      180

tacgcgagct gggcgaaagg ccgattcacc atccccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac aggcgcggac acggccacct atttctgtgc gagaggtaat      300

gctggtgttg ctgttggtgc cttgtggggc ccaggcaccc tcgtcaccgt ctcgagt         357


<210>  73
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4129 gL3 V-region - IGKV1-5 framework

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asp Ser Gly Ser 
                85                  90                  95      


Ser Val Phe Phe Asn Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  74
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4129 gH1 V-region - IGHV3-7 framework

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4129 gH4 V-region - IGHV3-7 framework

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4129 gH3 V-region - IGHV2-70 framework

<400>  76

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  77
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4129 gH5 V-region - IGHV2-70 framework

<400>  77

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ala Gly 
            20                  25                  30          


Tyr Trp Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Ala Gly Val Ala Val Gly Ala Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4131 VL region

<400>  78

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Ser Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Phe Tyr Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Ala Tyr Tyr Cys Gln Ser Ala Asp Gly Ser Ser Tyr 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105         


<210>  79
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4131 VL region

<400>  79
gacattgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg ctcagtcacc       60

atcaagtgcc aggccagtca gagcttttac aacctcttag cctggtatca gcagaaacca      120

gggcagcctc ccaaactcct gatctatgat gcatccgatc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggactgat ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccgcttacta ctgtcaaagt gctgatggta gtagttacgc tttcggcgga      300

gggaccgagg tggtcgtcaa a                                                321


<210>  80
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4131 VH region

<400>  80

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Val Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Val Ser Glu Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4131 VH region

<400>  81
caggagcaat tggaggagtc cgggggaggc ctggtcaagc ctgagggatc cctgacactc       60

acctgcacag cctctggagt ctccttcagt agcagctatt ggatatactg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttata ctggtagtag tggtagcact      180

tactacgcga gctgggcgaa aggccgattc accgtctccg aaacctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgagagca      300

agcgcttgga cctacggcat ggacctctgg ggcccgggca ccctcgtcac cgtctcgagt      360


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gL8 V-region - IGKV1-12 framework

<400>  82

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Phe Tyr Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ala Asp Gly Ser Ser Tyr 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  83
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gL3 V-region - IGKV1-12 framework

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Phe Tyr Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ala Asp Gly Ser Ser Tyr 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  84
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gH5 V-region - IGHV3-7 framework

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Val Ser Glu Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  85
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gH4 V-region - IGHV3-7 framework

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Val Ser Glu Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gH6 V-region - IGHV4-31 framework

<400>  86

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Val Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Val Ser Glu Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4131 gH3 V-region - IGHV4-31 framework

<400>  87

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Val Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Ile Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Val Ser Glu Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ser Ala Trp Thr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4133 VL region

<400>  88

Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Val Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asn Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Ser 
                85                  90                  95      


Ser Gly Trp Tyr Phe Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110         


<210>  89
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4133 VL region

<400>  89
gcgcaagtgc tgacccagac tccatctccc gtgtctgcag ttgtgggagg cacagtcagc       60

atcagttgcc aggccagtca gagtgtttat aataacaaca acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcttgatc tacgatgcat ccaaattggc atctggggtc      180

ccatcccggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt attatagtag tggttggtat      300

tttgctttcg gcggagggac caaggtggtg gtcaaa                                336


<210>  90
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4133 VH region

<400>  90

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  91
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4133 VH region

<400>  91
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacacta       60

acctgcacag cttctggatt ctccttcagt ggcaactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgga tgcctttata ctggtagtag tggtagcaca      180

tattacgcga gctgggcgaa aggccgattc accatctcca aaacctcgtc gaccacggtg      240

actctgcaaa tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgagagat      300

ctaggttatg aaattgatgg ttatgggggc ttgtggggcc agggcaccct cgtcaccgtc      360

tcgagt                                                                 366


<210>  92
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gL7 V-region - IGKV1D-13 framework

<400>  92

Ala Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asn Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Ser 
                85                  90                  95      


Ser Gly Trp Tyr Phe Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  93
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gL1 V-region - IGKV1D-13 framework

<400>  93

Ala Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Ser 
                85                  90                  95      


Ser Gly Trp Tyr Phe Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  94
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gH1 V-region - IGHV3-21 framework

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  95
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gH4 V-region - IGHV3-21 framework

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Thr Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  96
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gH3 V-region - IGHV4-4 framework

<400>  96

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  97
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4133 gH3 V-region - IGHV4-4 framework

<400>  97

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Leu Tyr Thr Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Thr Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Tyr Glu Ile Asp Gly Tyr Gly Gly Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Ab 4447

<400>  98

Gly Phe Ser Leu Ser Asn Tyr Ala Val Ser 
1               5                   10  


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Ab 4447

<400>  99

Ile Ile Tyr Ile Glu Thr Gly Thr Thr Trp Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Ab 4447

<400>  100

Glu Pro Tyr Glu Pro Tyr Asp Asp Ser Asn Ile Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Pro 
    


<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1  Ab4447

<400>  101

Gln Ala Ser Gln Ser Val Val Ser Gly Asn Tyr Leu Ala 
1               5                   10              


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Ab4447

<400>  102

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Ab4447

<400>  103

Leu Gly Glu Phe Ser Cys Ser Ser His Asp Cys Asn Ala 
1               5                   10              


<210>  104
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Ab4447 variant 1

<400>  104

Leu Gly Glu Phe Ser Ser Ser Ser His Asp Ser Asn Ala 
1               5                   10              


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Ab4447  variant 2

<400>  105

Leu Gly Glu Phe Ser Cys Ser Ser His Asp Ser Asn Ala 
1               5                   10              


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Ab4447 variant 3

<400>  106

Leu Gly Glu Phe Ser Ser Ser Ser His Asp Cys Asn Ala 
1               5                   10              


<210>  107
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4447 VL region

<400>  107

Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Val Ser Gly 
            20                  25                  30          


Asn Tyr Leu Ala Trp Leu Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln 
        35                  40                  45              


Leu Ile His Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Cys 
                85                  90                  95      


Ser Ser His Asp Cys Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  108
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4447 VL region

<400>  108
gcccaagtgc tgacccagac tccgtcccct gtgtctgcac ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagtgttgtt agtggcaatt acctagcctg gcttcagcag      120

aaaccagggc agcctcccaa gcaactgatc cattctgcat ccactctggc atctggggtc      180

tcatcgcggt tcagcggcag tggatctggg acacaattca ctctcaccat cagcggcgtg      240

cagtgtgaag atgctgccac ttactactgt ctaggcgaat ttagttgtag tagtcatgat      300

tgtaatgctt tcggcggagg gaccgaggtg gtggtcaaa                             339


<210>  109
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4447 VH region

<400>  109

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Val Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ile Glu Thr Gly Thr Thr Trp Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Ser Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu 
                85                  90                  95      


Pro Tyr Glu Pro Tyr Asp Asp Ser Asn Ile Tyr Tyr Gly Met Asp Pro 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  110
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4447 VH region

<400>  110
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcagtaac tatgcagtaa gctgggtccg ccaggctcca      120

ggggagggac tggaatggat cgggatcatt tatattgaaa ctggtaccac atggtacgcg      180

aactgggcga aaggccgatt caccatctcc aaaacctcga ccacggtgga tctgacaatc      240

accagtccgt caaccgagga cacggccacc tatttctgtg ccagagaacc ttatgaacct      300

tatgatgata gtaatattta ctacggcatg gacccctggg gcccaggcac cctcgtcacc      360

gtctcgagt                                                              369


<210>  111
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4447 gL1 V-region - IGKV1D-13 framework

<400>  111

Ala Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Val Ser Gly 
            20                  25                  30          


Asn Tyr Leu Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln 
        35                  40                  45              


Leu Ile His Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Cys 
                85                  90                  95      


Ser Ser His Asp Cys Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  112
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4447 gL2 V-region - IGKV1D-13 framework

<400>  112

Ala Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Val Ser Gly 
            20                  25                  30          


Asn Tyr Leu Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln 
        35                  40                  45              


Leu Ile His Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Ser 
                85                  90                  95      


Ser Ser His Asp Ser Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  113
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4447 gH1 V-region - IGHV3-48 framework

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Ile Glu Thr Gly Thr Thr Trp Tyr Ala Asn Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Tyr Glu Pro Tyr Asp Asp Ser Asn Ile Tyr Tyr Gly 
            100                 105                 110         


Met Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  114
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4447 gH3 V-region - IGHV4-59 framework

<400>  114

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Ile Glu Thr Gly Thr Thr Trp Tyr Ala Asn Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Tyr Glu Pro Tyr Asp Asp Ser Asn Ile Tyr Tyr Gly 
            100                 105                 110         


Met Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Ab 4450

<400>  115

Gly Phe Ser Leu Asn Asn Tyr Val Met Val 
1               5                   10  


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Ab 4450

<400>  116

Ile Ile Tyr Val Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Ab 4450

<400>  117

Asp Ala Gly His Ser Asp Val Asp Val Leu Asp Ile 
1               5                   10          


<210>  118
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Ab 4450

<400>  118

Gln Ser Ser Gln Ser Ile Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Ab 4450

<400>  119

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Ab 4450

<400>  120

Gln Gly Gly Gly Ser Gly Gly Asp Gly Ile Ala 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 4450 CDRL3 - variant 1

<400>  121

Gln Gly Gly Gly Ser Gly Gly Glu Gly Ile Ala 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 4450 CDRL3 - variant 2

<400>  122

Gln Gly Gly Gly Ser Gly Gly Asp Ala Ile Ala 
1               5                   10      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 4450 CDRL3 - variant 3

<400>  123

Gln Gly Gly Gly Ser Gly Gly Asp Ser Ile Ala 
1               5                   10      


<210>  124
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4450 VL region

<400>  124

Ala Ile Asp Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Ile Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Asp Gly Ile Ala Phe Gly Gly Gly Thr Lys Val Val Val Glu 
            100                 105                 110     


<210>  125
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4450 VL region

<400>  125
gccattgata tgacccagac tccatccccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtatttat aataataatg acttagcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tacgaagcat ccaaactggc atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagtggcgtg      240

cagtgtgatg atgctgccac ttactactgt cagggcggtg gtagtggtgg tgatggcatt      300

gctttcggcg gagggaccaa ggtggtcgtc gaa                                   333


<210>  126
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4450 VH region

<400>  126

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Ala Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Val 
            20                  25                  30          


Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Val Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Val Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ala 
                85                  90                  95      


Gly His Ser Asp Val Asp Val Leu Asp Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  127
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit Ab 4450 VH region

<400>  127
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg gggcacccct gacactcacc       60

tgcacagtct ctggattctc cctcaataac tatgtaatgg tctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt tatgttagtg gtaatgcata ctacgcgagc      180

tgggcaaaag gccgattcac catctccaga acctcgacca cggtggatct gaaagtgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagatgctgg tcatagtgat      300

gtcgatgttt tggatatttg gggcccgggc accctcgtca ccgtctcgag t               351


<210>  128
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4450 gL1 V-region - IGKV1-6 framework

<400>  128

Ala Ile Asp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Ile Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Asp Gly Ile Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  129
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4450 gH1 V-region - IGHV3-66 framework

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Val Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ala Gly His Ser Asp Val Asp Val Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  130
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4450 gH3 V-region - IGHV4-59 framework

<400>  130

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Val Met Val Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Val Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ala Gly His Ser Asp Val Asp Val Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 dAbH1

<400>  131

Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn 
1               5                   10  


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 dAbH1

<400>  132

Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 dAbH1

<400>  133

Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu 
1               5                   10              


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 dAbL1

<400>  134

Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
1               5                   10          


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 dAbL1

<400>  135

Glu Ala Ser Lys Leu Thr Ser 
1               5           


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 dAbL1

<400>  136

Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr 
1               5                   10      


<210>  137
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (no ds)

<400>  137

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  138
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (ds)

<400>  138

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  139
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain of anti-albumin antibody (no ds)

<400>  139

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  140
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain of anti-albumin antibody (ds)

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  141
<211>  1304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD45

<400>  141

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly 
            20                  25                  30          


Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu 
        35                  40                  45              


Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu 
    50                  55                  60                  


Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser 
65                  70                  75                  80  


Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr 
                85                  90                  95      


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
            100                 105                 110         


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
        115                 120                 125             


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
    130                 135                 140                 


Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
145                 150                 155                 160 


Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
                165                 170                 175     


Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
            180                 185                 190         


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
        195                 200                 205             


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
    210                 215                 220                 


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
225                 230                 235                 240 


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
                245                 250                 255     


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
            260                 265                 270         


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
        275                 280                 285             


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
    290                 295                 300                 


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
305                 310                 315                 320 


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
                325                 330                 335     


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
            340                 345                 350         


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
        355                 360                 365             


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
    370                 375                 380                 


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
385                 390                 395                 400 


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
                405                 410                 415     


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
            420                 425                 430         


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
        435                 440                 445             


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
    450                 455                 460                 


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
465                 470                 475                 480 


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
                485                 490                 495     


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
            500                 505                 510         


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
        515                 520                 525             


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
    530                 535                 540                 


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
545                 550                 555                 560 


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
                565                 570                 575     


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
            580                 585                 590         


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
        595                 600                 605             


Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
    610                 615                 620                 


Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
625                 630                 635                 640 


Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
                645                 650                 655     


Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
            660                 665                 670         


Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
        675                 680                 685             


Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
    690                 695                 700                 


Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
705                 710                 715                 720 


Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
                725                 730                 735     


Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
            740                 745                 750         


Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
        755                 760                 765             


Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
    770                 775                 780                 


Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
785                 790                 795                 800 


Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
                805                 810                 815     


Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
            820                 825                 830         


Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
        835                 840                 845             


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
    850                 855                 860                 


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
865                 870                 875                 880 


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
                885                 890                 895     


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
            900                 905                 910         


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
        915                 920                 925             


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
    930                 935                 940                 


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
945                 950                 955                 960 


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
                965                 970                 975     


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
            980                 985                 990         


Lys Glu Ser Glu His Asp Ser Asp  Glu Ser Ser Asp Asp  Asp Ser Asp 
        995                 1000                 1005             


Ser Glu  Glu Pro Ser Lys Tyr  Ile Asn Ala Ser Phe  Ile Met Ser 
    1010                 1015                 1020             


Tyr Trp  Lys Pro Glu Val Met  Ile Ala Ala Gln Gly  Pro Leu Lys 
    1025                 1030                 1035             


Glu Thr  Ile Gly Asp Phe Trp  Gln Met Ile Phe Gln  Arg Lys Val 
    1040                 1045                 1050             


Lys Val  Ile Val Met Leu Thr  Glu Leu Lys His Gly  Asp Gln Glu 
    1055                 1060                 1065             


Ile Cys  Ala Gln Tyr Trp Gly  Glu Gly Lys Gln Thr  Tyr Gly Asp 
    1070                 1075                 1080             


Ile Glu  Val Asp Leu Lys Asp  Thr Asp Lys Ser Ser  Thr Tyr Thr 
    1085                 1090                 1095             


Leu Arg  Val Phe Glu Leu Arg  His Ser Lys Arg Lys  Asp Ser Arg 
    1100                 1105                 1110             


Thr Val  Tyr Gln Tyr Gln Tyr  Thr Asn Trp Ser Val  Glu Gln Leu 
    1115                 1120                 1125             


Pro Ala  Glu Pro Lys Glu Leu  Ile Ser Met Ile Gln  Val Val Lys 
    1130                 1135                 1140             


Gln Lys  Leu Pro Gln Lys Asn  Ser Ser Glu Gly Asn  Lys His His 
    1145                 1150                 1155             


Lys Ser  Thr Pro Leu Leu Ile  His Cys Arg Asp Gly  Ser Gln Gln 
    1160                 1165                 1170             


Thr Gly  Ile Phe Cys Ala Leu  Leu Asn Leu Leu Glu  Ser Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Val Val Asp Ile  Phe Gln Val Val Lys  Ala Leu Arg 
    1190                 1195                 1200             


Lys Ala  Arg Pro Gly Met Val  Ser Thr Phe Glu Gln  Tyr Gln Phe 
    1205                 1210                 1215             


Leu Tyr  Asp Val Ile Ala Ser  Thr Tyr Pro Ala Gln  Asn Gly Gln 
    1220                 1225                 1230             


Val Lys  Lys Asn Asn His Gln  Glu Asp Lys Ile Glu  Phe Asp Asn 
    1235                 1240                 1245             


Glu Val  Asp Lys Val Lys Gln  Asp Ala Asn Cys Val  Asn Pro Leu 
    1250                 1255                 1260             


Gly Ala  Pro Glu Lys Leu Pro  Glu Ala Lys Glu Gln  Ala Glu Gly 
    1265                 1270                 1275             


Ser Glu  Pro Thr Ser Gly Thr  Glu Gly Pro Glu His  Ser Val Asn 
    1280                 1285                 1290             


Gly Pro  Ala Ser Pro Ala Leu  Asn Gln Gly Ser 
    1295                 1300                 


<210>  142
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD79a

<400>  142

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  143
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD79b

<400>  143

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  144
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4(7P14P) sequence

<400>  144

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  145
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCN4(7P14P) sequence

<400>  145
gctagcggag gcggaagaat gaaacaactt gaacccaagg ttgaagaatt gcttccgaaa       60

aattatcact tggaaaatga ggttgccaga ttaaagaaat tagttggcga acgccatcac      120

catcaccatc ac                                                          132


<210>  146
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52SR4 ds scFv sequence

<400>  146

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Cys Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Ala Ala Ala His His His His His His Glu Gln Lys Leu 
                245                 250                 255     


Ile Ser Glu Glu Asp Leu 
            260         


<210>  147
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  52SR4 ds scFv sequence

<400>  147
gatgcggtgg tgacccagga aagcgcgctg accagcagcc cgggcgaaac cgtgaccctg       60

acctgccgca gcagcaccgg cgcggtgacc accagcaact atgcgagctg ggtgcaggaa      120

aaaccggatc atctgtttac cggcctgatt ggcggcacca acaaccgcgc gccgggcgtg      180

ccggcgcgct ttagcggcag cctgattggc gataaagcgg cgctgaccat taccggcgcg      240

cagaccgaag atgaagcgat ttatttttgc gtgctgtggt atagcgacca ttgggtgttt      300

ggctgcggca ccaaactgac cgtgctgggt ggaggcggtg gctcaggcgg aggtggctca      360

ggcggtggcg ggtctggcgg cggcggcagc gatgtgcagc tgcagcagag cggcccgggc      420

ctggtggcgc cgagccagag cctgagcatt acctgcaccg tgagcggctt tctcctgacc      480

gattatggcg tgaactgggt gcgccagagc ccgggcaaat gcctggaatg gctgggcgtg      540

atttggggcg atggcattac cgattataac agcgcgctga aaagccgcct gagcgtgacc      600

aaagataaca gcaaaagcca ggtgtttctg aaaatgaaca gcctgcagag cggcgatagc      660

gcgcgctatt attgcgtgac cggcctgttt gattattggg gccagggcac caccctgacc      720

gtgagcagcg cggccgccca tcaccatcac catcacgaac agaaactgat tagcgaagaa      780

gatctgtaat ag                                                          792


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  148

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  149

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  150

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  151
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  151

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  152
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  152

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  153
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  153

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  154
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  154

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  155

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  156
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  156

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker Sequence

<400>  157

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  158

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  159

Asp Lys Thr His Thr Ser 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  160

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  161

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  162

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  163
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  163

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  164
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  164

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  165

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  166
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  166

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  167
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  168
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  168

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  169
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  169

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  170

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  171
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  171

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  172

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  173
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  173

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  174
<400>  174
000



<210>  175
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  175

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  176
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  176

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  177
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  177

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  178
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  178

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  179
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  179

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  180

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  181
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  181

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  182
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  182

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  183

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  184

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  185

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  186

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  187
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  187

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  188
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  188

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  189
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  189

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  190

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  191
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  191

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  192

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  193
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  193

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  194
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  194

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  195
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  195

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  196

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  197
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  197

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  198
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker sequence

<400>  198

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  199

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  200
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  200

Pro Pro Pro Pro 
1               


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  201

Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  202

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  203
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  203

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  204
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  204

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  205
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  205

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  206
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  206

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val Lys 
            20      


<210>  207
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  207

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15  


<210>  208
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  208

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  209
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  209

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15      


<210>  210
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  210

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15  


<210>  211
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  211

Arg Leu Met Glu Asp Ile Cys Leu Ala Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  212
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  212

Glu Val Arg Ser Phe Cys Thr Arg Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210>  213
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  213

Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210>  214
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequences

<400>  214

Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210>  215
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  215

Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10      


