                         SEQUENCE LISTING

<110>  BerGenBio AS
 
<120>  Biomarkers

<130>  RKA/LP7211626

<150>  GB 1512133.8
<151>  2015-07-10

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Phe Ala Asn Leu Arg Lys Val Leu Ile Ser Asp Ser Leu Asp 
1               5                   10                  15      


Pro Cys Cys Arg Lys Ile Leu Gln Asp Gly Gly Leu Gln Val Val Glu 
            20                  25                  30          


Lys Gln Asn Leu Ser Lys Glu Glu Leu Ile Ala Glu Leu Gln Asp Cys 
        35                  40                  45              


Glu Gly Leu Ile Val Arg Ser Ala Thr Lys Val Thr Ala Asp Val Ile 
    50                  55                  60                  


Asn Ala Ala Glu Lys Leu Gln Val Val Gly Arg Ala Gly Thr Gly Val 
65                  70                  75                  80  


Asp Asn Val Asp Leu Glu Ala Ala Thr Arg Lys Gly Ile Leu Val Met 
                85                  90                  95      


Asn Thr Pro Asn Gly Asn Ser Leu Ser Ala Ala Glu Leu Thr Cys Gly 
            100                 105                 110         


Met Ile Met Cys Leu Ala Arg Gln Ile Pro Gln Ala Thr Ala Ser Met 
        115                 120                 125             


Lys Asp Gly Lys Trp Glu Arg Lys Lys Phe Met Gly Thr Glu Leu Asn 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg Glu Val 
145                 150                 155                 160 


Ala Thr Arg Met Gln Ser Phe Gly Met Lys Thr Ile Gly Tyr Asp Pro 
                165                 170                 175     


Ile Ile Ser Pro Glu Val Ser Ala Ser Phe Gly Val Gln Gln Leu Pro 
            180                 185                 190         


Leu Glu Glu Ile Trp Pro Leu Cys Asp Phe Ile Thr Val His Thr Pro 
        195                 200                 205             


Leu Leu Pro Ser Thr Thr Gly Leu Leu Asn Asp Asn Thr Phe Ala Gln 
    210                 215                 220                 


Cys Lys Lys Gly Val Arg Val Val Asn Cys Ala Arg Gly Gly Ile Val 
225                 230                 235                 240 


Asp Glu Gly Ala Leu Leu Arg Ala Leu Gln Ser Gly Gln Cys Ala Gly 
                245                 250                 255     


Ala Ala Leu Asp Val Phe Thr Glu Glu Pro Pro Arg Asp Arg Ala Leu 
            260                 265                 270         


Val Asp His Glu Asn Val Ile Ser Cys Pro His Leu Gly Ala Ser Thr 
        275                 280                 285             


Lys Glu Ala Gln Ser Arg Cys Gly Glu Glu Ile Ala Val Gln Phe Val 
    290                 295                 300                 


Asp Met Val Lys Gly Lys Ser Leu Thr Gly Val Val Asn Ala Gln Ala 
305                 310                 315                 320 


Leu Thr Ser Ala Phe Ser Pro His Thr Lys Pro Trp Ile Gly Leu Ala 
                325                 330                 335     


Glu Ala Leu Gly Thr Leu Met Arg Ala Trp Ala Gly Ser Pro Lys Gly 
            340                 345                 350         


Thr Ile Gln Val Ile Thr Gln Gly Thr Ser Leu Lys Asn Ala Gly Asn 
        355                 360                 365             


Cys Leu Ser Pro Ala Val Ile Val Gly Leu Leu Lys Glu Ala Ser Lys 
    370                 375                 380                 


Gln Ala Asp Val Asn Leu Val Asn Ala Lys Leu Leu Val Lys Glu Ala 
385                 390                 395                 400 


Gly Leu Asn Val Thr Thr Ser His Ser Pro Ala Ala Pro Gly Glu Gln 
                405                 410                 415     


Gly Phe Gly Glu Cys Leu Leu Ala Val Ala Leu Ala Gly Ala Pro Tyr 
            420                 425                 430         


Gln Ala Val Gly Leu Val Gln Gly Thr Thr Pro Val Leu Gln Gly Leu 
        435                 440                 445             


Asn Gly Ala Val Phe Arg Pro Glu Val Pro Leu Arg Arg Asp Leu Pro 
    450                 455                 460                 


Leu Leu Leu Phe Arg Thr Gln Thr Ser Asp Pro Ala Met Leu Pro Thr 
465                 470                 475                 480 


Met Ile Gly Leu Leu Ala Glu Ala Gly Val Arg Leu Leu Ser Tyr Gln 
                485                 490                 495     


Thr Ser Leu Val Ser Asp Gly Glu Thr Trp His Val Met Gly Ile Ser 
            500                 505                 510         


Ser Leu Leu Pro Ser Leu Glu Ala Trp Lys Gln His Val Thr Glu Ala 
        515                 520                 525             


Phe Gln Phe His Phe 
    530             


<210>  2
<211>  2478
<212>  DNA
<213>  Homo sapiens

<400>  2
cacctttccg cgggccgcgg ggatggcggc gcagggcgta gggcctgggc cggggtcggc     60

ggcgcccccg gggctggagg cggcccggca gaagctggcg ctgcggcgga agaaggtgct    120

gagcaccgaa ggagatggag ctgtacgagc tggcgcaggc ggcgggcggc gctatcgacc    180

ccgacgtgtt caagatcctg gtggacctgc tgaagctgaa cgtggccccc ctcgccgtct    240

tccagatgct caagtccatg tgtgccgggc agaggctagc gagcgagccc caggaccctg    300

cggccgtgtc tctgcccacg tcgagcgtgc ccgagacccg agggagaaac aaaggcagcg    360

ctgccctcgg gggagcattg gccctggcgg aacgcagcag ccgcgaagga tccagccaga    420

ggatgccacg ccagcccagc gctaccaggc tgcccaaggg gggcgggcct gggaagagcc    480

ctacacgggg cagcacctag gatggggcag agacttgttg catctttgtc cccagcaaag    540

gctacatgtt acctccttca attgataata aacctttctg agatgcaaac tcgagaatac    600

tgcccagtta ctctagcgcg ccaggccgaa ccgcagcttc ttggcttagg tacttctact    660

cacagcggcc gattccgagg ccaactccag caatggcttt tgcaaatctg cggaaagtgc    720

tcatcagtga cagcctggac ccttgctgcc ggaagatctt gcaagaggga gggctgcagg    780

tggtggaaaa gcagaacctt agcaaagagg agctgatagc ggagctgcag gactgtgaag    840

gccttattgt tcgctctgcc accaaggtga ccgctgatgt catcaacgca gctgagaaac    900

tccaggtggt gggcagggct ggcacaggtg tggacaatgt ggatctggag gccgcaacaa    960

ggaagggcat cttggttatg aacaccccca atgggaacag cctcagtgcc gcagaactca   1020

cttgtggaat gatcatgtgc ctggccaggc agattcccca ggcgacggct tcgatgaagg   1080

acggcaaatg ggagcggaag aagttcatgg gaacagagct gaatggaaag accctgggaa   1140

ttcttggcct gggcaggatt gggagagagg tagctacccg gatgcagtcc tttgggatga   1200

agactatagg gtatgacccc atcatttccc cagaggtctc ggcctccttt ggtgttcagc   1260

agctgcccct ggaggagatc tggcctctct gtgatttcat cactgtgcac actcctctcc   1320

tgccctccac gacaggcttg ctgaatgaca acacctttgc ccagtgcaag aagggggtgc   1380

gtgtggtgaa ctgtgcccgt ggagggatcg tggacgaagg cgccctgctc cgggccctgc   1440

agtctggcca gtgtgccggg gctgcactgg acgtgtttac ggaagagccg ccacgggacc   1500

gggccttggt ggaccatgag aatgtcatca gctgtcccca cctgggtgcc agcaccaagg   1560

aggctcagag ccgctgtggg gaggaaattg ctgttcagtt cgtggacatg gtgaagggga   1620

aatctctcac gggggttgtg aatgcccagg cccttaccag tgccttctct ccacacacca   1680

agccttggat tggtctggca gaagctctgg ggacactgat gcgagcctgg gctgggtccc   1740

ccaaagggac catccaggtg ataacacagg gaacatccct gaagaatgct gggaactgcc   1800

taagccccgc agtcattgtc ggcctcctga aagaggcttc caagcaggcg gatgtgaact   1860

tggtgaacgc taagctgctg gtgaaagagg ctggcctcaa tgtcaccacc tcccacagcc   1920

ctgctgcacc aggggagcaa ggcttcgggg aatgcctcct ggccgtggcc ctggcaggcg   1980

ccccttacca ggctgtgggc ttggtccaag gcactacacc tgtactgcag gggctcaatg   2040

gagctgtctt caggccagaa gtgcctctcc gcagggacct gcccctgctc ctattccgga   2100

ctcagacctc tgaccctgca atgctgccta ccatgattgg cctcctggca gaggcaggcg   2160

tgcggctgct gtcctaccag acttcactgg tgtcagatgg ggagacctgg cacgtcatgg   2220

gcatctcctc cttgctgccc agcctggaag cgtggaagca gcatgtgact gaagccttcc   2280

agttccactt ctaaccttgg agctcactgg tccctgcctc tggggctttt ctgaagaaac   2340

ccacccactg tgatcaatag ggagagaaaa tccacattct tgggctgaac gcgggcctct   2400

gacactgctt acactgcact ctgaccctgt agtacagcaa taaccgtcta ataaagagcc   2460

tacccccaaa aaaaaaaa                                                 2478


<210>  3
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  4
<211>  3227
<212>  DNA
<213>  Homo sapiens

<400>  4
gctgggcaaa gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa     60

tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg    120

ctgggagccc agcaacttct gaggaaagtt tggcacccat ggcgtggcgg tgccccagga    180

tgggcagggt cccgctggcc tggtgcttgg cgctgtgcgg ctgggcgtgc atggccccca    240

ggggcacgca ggctgaagaa agtcccttcg tgggcaaccc agggaatatc acaggtgccc    300

ggggactcac gggcaccctt cggtgtcagc tccaggttca gggagagccc cccgaggtac    360

attggcttcg ggatggacag atcctggagc tcgcggacag cacccagacc caggtgcccc    420

tgggtgagga tgaacaggat gactggatag tggtcagcca gctcagaatc acctccctgc    480

agctttccga cacgggacag taccagtgtt tggtgtttct gggacatcag accttcgtgt    540

cccagcctgg ctatgttggg ctggagggct tgccttactt cctggaggag cccgaagaca    600

ggactgtggc cgccaacacc cccttcaacc tgagctgcca agctcaggga cccccagagc    660

ccgtggacct actctggctc caggatgctg tccccctggc cacggctcca ggtcacggcc    720

cccagcgcag cctgcatgtt ccagggctga acaagacatc ctctttctcc tgcgaagccc    780

ataacgccaa gggggtcacc acatcccgca cagccaccat cacagtgctc ccccagcagc    840

cccgtaacct ccacctggtc tcccgccaac ccacggagct ggaggtggct tggactccag    900

gcctgagcgg catctacccc ctgacccact gcaccctgca ggctgtgctg tcagacgatg    960

ggatgggcat ccaggcggga gaaccagacc ccccagagga gcccctcacc tcgcaagcat   1020

ccgtgccccc ccatcagctt cggctaggca gcctccatcc tcacacccct tatcacatcc   1080

gcgtggcatg caccagcagc cagggcccct catcctggac ccactggctt cctgtggaga   1140

cgccggaggg agtgcccctg ggccccccta agaacattag tgctacgcgg aatgggagcc   1200

aggccttcgt gcattggcaa gagccccggg cgcccctgca gggtaccctg ttagggtacc   1260

ggctggcgta tcaaggccag gacaccccag aggtgctaat ggacataggg ctaaggcaag   1320

aggtgaccct ggagctgcag ggggacgggt ctgtgtccaa tctgacagtg tgtgtggcag   1380

cctacactgc tgctggggat ggaccctgga gcctcccagt acccctggag gcctggcgcc   1440

cagtgaagga accttcaact cctgccttct cgtggccctg gtggtatgta ctgctaggag   1500

cagtcgtggc cgctgcctgt gtcctcatct tggctctctt ccttgtccac cggcgaaaga   1560

aggagacccg ttatggagaa gtgtttgaac caacagtgga aagaggtgaa ctggtagtca   1620

ggtaccgcgt gcgcaagtcc tacagtcgtc ggaccactga agctaccttg aacagcctgg   1680

gcatcagtga agagctgaag gagaagctgc gggatgtgat ggtggaccgg cacaaggtgg   1740

ccctggggaa gactctggga gagggagagt ttggagctgt gatggaaggc cagctcaacc   1800

aggacgactc catcctcaag gtggctgtga agacgatgaa gattgccatc tgcacgaggt   1860

cagagctgga ggatttcctg agtgaagcgg tctgcatgaa ggaatttgac catcccaacg   1920

tcatgaggct catcggtgtc tgtttccagg gttctgaacg agagagcttc ccagcacctg   1980

tggtcatctt acctttcatg aaacatggag acctacacag cttcctcctc tattcccggc   2040

tcggggacca gccagtgtac ctgcccactc agatgctagt gaagttcatg gcagacatcg   2100

ccagtggcat ggagtatctg agtaccaaga gattcataca ccgggacctg gcggccagga   2160

actgcatgct gaatgagaac atgtccgtgt gtgtggcgga cttcgggctc tccaagaaga   2220

tctacaatgg ggactactac cgccagggac gtatcgccaa gatgccagtc aagtggattg   2280

ccattgagag tctagctgac cgtgtctaca ccagcaagag cgatgtgtgg tccttcgggg   2340

tgacaatgtg ggagattgcc acaagaggcc aaaccccata tccgggcgtg gagaacagcg   2400

agatttatga ctatctgcgc cagggaaatc gcctgaagca gcctgcggac tgtctggatg   2460

gactgtatgc cttgatgtcg cggtgctggg agctaaatcc ccaggaccgg ccaagtttta   2520

cagagctgcg ggaagatttg gagaacacac tgaaggcctt gcctcctgcc caggagcctg   2580

acgaaatcct ctatgtcaac atggatgagg gtggaggtta tcctgaaccc cctggagctg   2640

caggaggagc tgacccccca acccagccag accctaagga ttcctgtagc tgcctcactg   2700

cggctgaggt ccatcctgct ggacgctatg tcctctgccc ttccacaacc cctagccccg   2760

ctcagcctgc tgataggggc tccccagcag ccccagggca ggaggatggt gcctgagaca   2820

accctccacc tggtactccc tctcaggatc caagctaagc actgccactg gggaaaactc   2880

caccttccca cttttccacc ccacgcctta tccccacttg cagccctgtc ttcctaccta   2940

tcccacctcc atcccagaca ggtccctccc cttctctgtg cagtagcatc accttgaaag   3000

cagtagcatc accatctgta aaaggaaggg gttggattgc aatatctgaa gccctcccag   3060

gtgttaacat tccaagactc tagagtccaa ggtttaaaga gtctagattc aaaggttcta   3120

ggtttcaaag atgctgtgag tctttggttc taaggacctg aaattccaaa gtctctaatt   3180

ctattaaagt gctaaggttc taaggcaaaa aaaaaaaaaa aaaaaaa                 3227


<210>  5
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  6
<211>  1708
<212>  DNA
<213>  Homo sapiens

<400>  6
aggggagtca tcatgagcga tgttaccatt gtgaaggaag gttgggttca gaagagggga     60

gaatatataa aaaactggag gccaagatac ttccttttga agacagatgg ctcattcata    120

ggatataaag agaaacctca agatgtggat ttaccttatc ccctcaacaa cttttcagtg    180

gcaaaatgcc agttaatgaa aacagaacga ccaaagccaa acacatttat aatcagatgt    240

ctccagtgga ctactgttat agagagaaca tttcatgtag atactccaga ggaaagggaa    300

gaatggacag aagctatcca ggctgtagca gacagactgc agaggcaaga agaggagaga    360

atgaattgta gtccaacttc acaaattgat aatataggag aggaagagat ggatgcctct    420

acaacccatc ataaaagaaa gacaatgaat gattttgact atttgaaact actaggtaaa    480

ggcacttttg ggaaagttat tttggttcga gagaaggcaa gtggaaaata ctatgctatg    540

aagattctga agaaagaagt cattattgca aaggatgaag tggcacacac tctaactgaa    600

agcagagtat taaagaacac tagacatccc tttttaacat ccttgaaata ttccttccag    660

acaaaagacc gtttgtgttt tgtgatggaa tatgttaatg ggggcgagct gtttttccat    720

ttgtcgagag agcgggtgtt ctctgaggac cgcacacgtt tctatggtgc agaaattgtc    780

tctgccttgg actatctaca ttccggaaag attgtgtacc gtgatctcaa gttggagaat    840

ctaatgctgg acaaagatgg ccacataaaa attacagatt ttggactttg caaagaaggg    900

atcacagatg cagccaccat gaagacattc tgtggcactc cagaatatct ggcaccagag    960

gtgttagaag ataatgacta tggccgagca gtagactggt ggggcctagg ggttgtcatg   1020

tatgaaatga tgtgtgggag gttacctttc tacaaccagg accatgagaa actttttgaa   1080

ttaatattaa tggaagacat taaatttcct cgaacactct cttcagatgc aaaatcattg   1140

ctttcagggc tcttgataaa ggatccaaat aaacgccttg gtggaggacc agatgatgca   1200

aaagaaatta tgagacacag tttcttctct ggagtaaact ggcaagatgt atatgataaa   1260

aagcttgtac ctccttttaa acctcaagta acatctgaga cagatactag atattttgat   1320

gaagaattta cagctcagac tattacaata acaccacctg aaaaatatga tgaggatggt   1380

atggactgca tggacaatga gaggcggccg catttccctc aattttccta ctctgcaagt   1440

ggacgagaat aagtctcttt cattctgcta cttcactgtc atcttcaatt tattactgaa   1500

aatgattcct ggacatcacc agtcctagct cttacacata gcaggggcac cttccgacat   1560

cccagaccag ccaagggtcc tcacccctcg ccacctttca ccctcatgaa aacacacata   1620

cacgcaaata cactccagtt tttgtttttg catgaaattg tatctcagtc taaggtctca   1680

tgctgttgct gctactgtct tactatta                                      1708


<210>  7
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Ala Asn Gln Cys Pro Leu Val Val Glu Pro Ser Tyr Pro Asp 
1               5                   10                  15      


Leu Val Ile Asn Val Gly Glu Val Thr Leu Gly Glu Glu Asn Arg Lys 
            20                  25                  30          


Lys Leu Gln Lys Ile Gln Arg Asp Gln Glu Lys Glu Arg Val Met Arg 
        35                  40                  45              


Ala Ala Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Arg Met Ala 
    50                  55                  60                  


Lys Lys Val Glu His Pro Val Glu Met Gly Leu Asp Leu Glu Gln Ser 
65                  70                  75                  80  


Leu Arg Glu Leu Ile Gln Ser Ser Asp Leu Gln Ala Phe Phe Glu Thr 
                85                  90                  95      


Lys Gln Gln Gly Arg Cys Phe Tyr Ile Phe Val Lys Ser Trp Ser Ser 
            100                 105                 110         


Gly Pro Phe Pro Glu Asp Arg Ser Val Lys Pro Arg Leu Cys Ser Leu 
        115                 120                 125             


Ser Ser Ser Leu Tyr Arg Arg Ser Glu Thr Ser Val Arg Ser Met Asp 
    130                 135                 140                 


Ser Arg Glu Ala Phe Cys Phe Leu Lys Thr Lys Arg Lys Pro Lys Ile 
145                 150                 155                 160 


Leu Glu Glu Gly Pro Phe His Lys Ile His Lys Gly Val Tyr Gln Glu 
                165                 170                 175     


Leu Pro Asn Ser Asp Pro Ala Asp Pro Asn Ser Asp Pro Ala Asp Leu 
            180                 185                 190         


Ile Phe Gln Lys Asp Tyr Leu Glu Tyr Gly Glu Ile Leu Pro Phe Pro 
        195                 200                 205             


Glu Ser Gln Leu Val Glu Phe Lys Gln Phe Ser Thr Lys His Phe Gln 
    210                 215                 220                 


Glu Tyr Val Lys Arg Thr Ile Pro Glu Tyr Val Pro Ala Phe Ala Asn 
225                 230                 235                 240 


Thr Gly Gly Gly Tyr Leu Phe Ile Gly Val Asp Asp Lys Ser Arg Glu 
                245                 250                 255     


Val Leu Gly Cys Ala Lys Glu Asn Val Asp Pro Asp Ser Leu Arg Arg 
            260                 265                 270         


Lys Ile Glu Gln Ala Ile Tyr Lys Leu Pro Cys Val His Phe Cys Gln 
        275                 280                 285             


Pro Gln Arg Pro Ile Thr Phe Thr Leu Lys Ile Val Asn Val Leu Lys 
    290                 295                 300                 


Arg Gly Glu Leu Tyr Gly Tyr Ala Cys Met Ile Arg Val Asn Pro Phe 
305                 310                 315                 320 


Cys Cys Ala Val Phe Ser Glu Ala Pro Asn Ser Trp Ile Val Glu Asp 
                325                 330                 335     


Lys Tyr Val Cys Ser Leu Thr Thr Glu Lys Trp Val Gly Met Met Thr 
            340                 345                 350         


Asp Thr Asp Pro Asp Leu Leu Gln Leu Ser Glu Asp Phe Glu Cys Gln 
        355                 360                 365             


Leu Ser Leu Ser Ser Gly Pro Pro Leu Ser Arg Pro Val Tyr Ser Lys 
    370                 375                 380                 


Lys Gly Leu Glu His Lys Lys Glu Leu Gln Gln Leu Leu Phe Ser Val 
385                 390                 395                 400 


Pro Pro Gly Tyr Leu Arg Tyr Thr Pro Glu Ser Leu Trp Arg Asp Leu 
                405                 410                 415     


Ile Ser Glu His Arg Gly Leu Glu Glu Leu Ile Asn Lys Gln Met Gln 
            420                 425                 430         


Pro Phe Phe Arg Gly Ile Leu Ile Phe Ser Arg Ser Trp Ala Val Asp 
        435                 440                 445             


Leu Asn Leu Gln Glu Lys Pro Gly Val Ile Cys Asp Ala Leu Leu Ile 
    450                 455                 460                 


Ala Gln Asn Ser Thr Pro Ile Leu Tyr Thr Ile Leu Arg Glu Gln Asp 
465                 470                 475                 480 


Ala Glu Gly Gln Asp Tyr Cys Thr Arg Thr Ala Phe Thr Leu Lys Gln 
                485                 490                 495     


Lys Leu Val Asn Met Gly Gly Tyr Thr Gly Lys Val Cys Val Arg Ala 
            500                 505                 510         


Lys Val Leu Cys Leu Ser Pro Glu Ser Ser Ala Glu Ala Leu Glu Ala 
        515                 520                 525             


Ala Val Ser Pro Met Asp Tyr Pro Ala Ser Tyr Ser Leu Ala Gly Thr 
    530                 535                 540                 


Gln His Met Glu Ala Leu Leu Gln Ser Leu Val Ile Val Leu Leu Gly 
545                 550                 555                 560 


Phe Arg Ser Leu Leu Ser Asp Gln Leu Gly Cys Glu Val Leu Asn Leu 
                565                 570                 575     


Leu Thr Ala Gln Gln Tyr Glu Ile Phe Ser Arg Ser Leu Arg Lys Asn 
            580                 585                 590         


Arg Glu Leu Phe Val His Gly Leu Pro Gly Ser Gly Lys Thr Ile Met 
        595                 600                 605             


Ala Met Lys Ile Met Glu Lys Ile Arg Asn Val Phe His Cys Glu Ala 
    610                 615                 620                 


His Arg Ile Leu Tyr Val Cys Glu Asn Gln Pro Leu Arg Asn Phe Ile 
625                 630                 635                 640 


Ser Asp Arg Asn Ile Cys Arg Ala Glu Thr Arg Lys Thr Phe Leu Arg 
                645                 650                 655     


Glu Asn Phe Glu His Ile Gln His Ile Val Ile Asp Glu Ala Gln Asn 
            660                 665                 670         


Phe Arg Thr Glu Asp Gly Asp Trp Tyr Gly Lys Ala Lys Ser Ile Thr 
        675                 680                 685             


Arg Arg Ala Lys Gly Gly Pro Gly Ile Leu Trp Ile Phe Leu Asp Tyr 
    690                 695                 700                 


Phe Gln Thr Ser His Leu Asp Cys Ser Gly Leu Pro Pro Leu Ser Asp 
705                 710                 715                 720 


Gln Tyr Pro Arg Glu Glu Leu Thr Arg Ile Val Arg Asn Ala Asp Pro 
                725                 730                 735     


Ile Ala Lys Tyr Leu Gln Lys Glu Met Gln Val Ile Arg Ser Asn Pro 
            740                 745                 750         


Ser Phe Asn Ile Pro Thr Gly Cys Leu Glu Val Phe Pro Glu Ala Glu 
        755                 760                 765             


Trp Ser Gln Gly Val Gln Gly Thr Leu Arg Ile Lys Lys Tyr Leu Thr 
    770                 775                 780                 


Val Glu Gln Ile Met Thr Cys Val Ala Asp Thr Cys Arg Arg Phe Phe 
785                 790                 795                 800 


Asp Arg Gly Tyr Ser Pro Lys Asp Val Ala Val Leu Val Ser Thr Ala 
                805                 810                 815     


Lys Glu Val Glu His Tyr Lys Tyr Glu Leu Leu Lys Ala Met Arg Lys 
            820                 825                 830         


Lys Arg Val Val Gln Leu Ser Asp Ala Cys Asp Met Leu Gly Asp His 
        835                 840                 845             


Ile Val Leu Asp Ser Val Arg Arg Phe Ser Gly Leu Glu Arg Ser Ile 
    850                 855                 860                 


Val Phe Gly Ile His Pro Arg Thr Ala Asp Pro Ala Ile Leu Pro Asn 
865                 870                 875                 880 


Val Leu Ile Cys Leu Ala Ser Arg Ala Lys Gln His Leu Tyr Ile Phe 
                885                 890                 895     


Pro Trp Gly Gly His 
            900     


<210>  8
<211>  4620
<212>  DNA
<213>  Homo sapiens

<400>  8
gtgcagtggc acgatcttgg ttcaccacaa tctcgtctcg aaggctcagg tgattctctc     60

acctcagccg cctgagtagc tgggaccaca gtttcagctg tgagttcaac atggaggcaa    120

atcagtgccc cctggttgtg gaaccatctt acccagacct ggtcatcaat gtaggagaag    180

tgactcttgg agaagaaaac agaaaaaagc tgcagaaaat tcagagagac caagagaagg    240

agagagttat gcgggctgca tgtgctttat taaactcagg aggaggagtg attcgaatgg    300

ccaagaaggt tgagcatccc gtggagatgg gactggattt agaacagtct ttgagagagc    360

ttattcagtc ttcagatctg caggctttct ttgagaccaa gcaacaagga aggtgttttt    420

acatttttgt taaatcttgg agcagtggcc ctttccctga agatcgctct ttcaagcccc    480

gcctttgcag cctcagttct tcattatacc tgtagatctg agacctctgt gcgttccatg    540

gactcaagag aggcattctg tttcctgaag accaaaagga agccaaaaat cttggaagaa    600

ggaccttttc acaaaattca caagggtgta taccaagagc tccctaactc ggatcctgct    660

gacccaaact cggatcctgc tgacctaatt ttccaaaaag actatcttga atatggtgaa    720

atcctgcctt ttcctgagtc tcagttagta gagtttaaac agttctctac aaaacacttc    780

caagaatatg taaaaaggac aattccagaa tacgtccctg catttgcaaa cactggagga    840

ggctatcttt ttattggagt ggatgataag agtagggaag tcctgggatg tgcaaaagaa    900

aatgttgacc ctgactcttt gagaaggaaa atagaacaag ccatatacaa actaccttgt    960

gttcattttt gccaacccca acgcccgata accttcacac tcaaaattgt ggatgtgtta   1020

aaaaggggag agctctatgg ctatgcttgc atgatcagag taaatccctt ctgctgtgca   1080

gtgttctcag aagctcccaa ttcatggata gtggaggaca agtacgtctg cagcctgaca   1140

accgagaaat gggtaggcat gatgacagac acagatccag atcttctaca gttgtctgaa   1200

gattttgaat gtcagctgag tctatctagt gggcctcccc ttagcagacc agtgtactcc   1260

aagaaaggcc tggaacataa aaaggaactc cagcaacttt tattttcagt cccaccagga   1320

tatttgcgat atactccaga gtcactctgg agggacctga tctcagagca cagaggacta   1380

gaggagttaa taaataagca aatgcaacct ttctttcggg gaattttgat cttctctaga   1440

agttgggctg tggacctgaa cttgcaggag aagccaggag tcatctgtga tgctctgctg   1500

atagcacaga acagcacccc cattctctac accattctca gggagcagga tgcagagggc   1560

caggactact gcactcgcac tgcctttact ttgaagcaga agctagtgaa catggggggc   1620

tacaccggga aggtgtgtgt cagggccaag gtcctctgcc tgagtcctga gagcagcgca   1680

gaggccttgg aggctgcagt gtctccgatg gattaccctg cgtcctatag ccttgcaggc   1740

acccagcaca tggaagccct gctgcagtcc ctcgtgattg tcttactcgg cttcaggtct   1800

ctcttgagtg accagctcgg ctgtgaggtt ttaaatctgc tcacagccca gcagtatgag   1860

atattctcca gaagcctccg caagaacaga gagttgtttg tccacggctt acctggctca   1920

gggaagacca tcatggccat gaagatcatg gagaagatca ggaatgtgtt tcactgtgag   1980

gcacacagaa ttctctacgt ttgtgaaaac cagcctctga ggaactttat cagtgataga   2040

aatatctgcc gagcagagac ccggaaaact ttcctaagag aaaactttga acacattcaa   2100

cacatcgtca ttgacgaagc tcagaatttc cgtactgaag atggggactg gtatgggaag   2160

gcaaaaagca tcactcggag agcaaagggt ggcccaggaa ttctctggat ctttctggat   2220

tactttcaga ccagccactt ggattgcagt ggcctccctc ctctctcaga ccaatatcca   2280

agagaagagc tcaccagaat agttcgcaat gcagatccaa tagccaagta cttacaaaaa   2340

gaaatgcaag taattagaag taatccttca tttaacatcc ccactgggtg cctcgaggta   2400

tttcctgaag ccgaatggtc ccagggtgtt cagggaacct tacgaattaa gaaatacttg   2460

actgtggagc aaataatgac ctgtgtggca gacacgtgca ggcgcttctt tgataggggc   2520

tattctccaa aggatgttgc tgtgcttgtc agcaccgcaa aagaagtgga gcactataag   2580

tatgagctct tgaaagcaat gaggaagaaa agggtggtgc agctcagtga tgcatgtgat   2640

atgttgggtg atcacattgt gttggacagt gttcggcgat tctcaggcct ggaaaggagc   2700

atagtgtttg ggatccatcc aaggacagct gacccagcta tcttacccaa tgttctgatc   2760

tgtctggctt ccagggcaaa acaacacctg tatatttttc cgtggggtgg ccattaggaa   2820

gaactccaaa tcaaaatgct atgtaaatgt ctatgggtga cagtctgctg atggtagaaa   2880

cctttctttt tagttcacaa gtcagagatt tggacggagc tgacacaaag agtttggagc   2940

tcccccattt ctggctctcc tttcaggggt tccttcccca acccttttca gcagcggtgg   3000

ctgcccccca ttctgacccc tgactcttcc agccagaaag atggtggttt tctaaaggaa   3060

ctttagctgt cctgcacaat gccgatctgt gtcttgcatt ttgggtaaaa gccataaaaa   3120

taagaaactc agcctgtggc ctttctttct tccaaggctg ggcttctttt tttaagtgac   3180

ttcatgcagt ttgttgcttt taaaaatttg tccagaatcg ttttctgcag aagcatggtc   3240

tgttaggagc ttactggccg tagcagaagc aattgtttcc tgaattcttg acatttatct   3300

ttgctgtatt catttagggc ttgggagagt ccgaagataa ttcagtcact gtcagattaa   3360

taattctgtc aggacaaaga ataccgttat gattatttaa tcctttaaaa ttgtggtctc   3420

cagagcttgt tctcagaatg gcccagacca agccttaatt gtgatagtga atattaatgg   3480

tcactttaag gagaaattat aggccaagat gaaatgaaca taaacctgtt tgccctggct   3540

ttcagtggaa gatgatatta gagaccaaaa tctggttctg aaggtgtgta tcagccctaa   3600

ggtgaaccag acttgggaaa gattgtcttt aaaaatcaat gagtttatgt tttaacttct   3660

cagcttagtt ctatgcattg ctctataaca cacctagtta agttttatgt tattcttgaa   3720

ctgtgatttt ttttctattt actttcatgg tttggtgggc cattgttatg gactgaatgt   3780

ttgtgtccca cccttcaccc ccaaattccc gtgttgaagc cccaacctgc actgtggagc   3840

tggggctgct aaggaagtaa ttaaggttac atgaagtcat ggtggggctc tgatctgcta   3900

aggttggtgt ccttataggg agagacccca gagagcttgt tccctccctc cctgtgcatg   3960

caaacaagag ggcatgggag cacacagaga gatggcagcc acctacaagc caagaggaga   4020

agcctcacaa tcaaactctc gctgctggcg agagtcttgg actctgtctt ggacttccag   4080

cctccagact gtgagaaaca aatttctgtt gtttcagctt ctcagtctct ggtgttttgt   4140

tattgcagcc tgagaacaca gctgtacgat tatttgtcaa acagaaaaca ctgatactta   4200

acaatgctaa tgcaattatt tatttgcttt tcagtctcta caaaacgttc taaaacacta   4260

atctaaatat taacagtaaa atatttgcat aactaatgga aactaagaaa tcatatgacc   4320

aatatttcac ttattggtaa tcttactcta ctgatttccc cccagactgt gatttttgaa   4380

cttccttgcc tttctcctgt ctttctgtgt ttattcatgg aattccagtt atctgggctt   4440

gaaattgcag gctctcctaa cttaagcaaa atctgacaga tcagcaaaat gagataaatg   4500

tttctttttt ctttctgact gcattaaatc agatacaact cagcattaaa aagctatctt   4560

tgtaaatgtt gttactaata aattagtctt ataagatccc tggactttgg agttgttgca   4620


<210>  9
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  10
<211>  1866
<212>  DNA
<213>  Homo sapiens

<400>  10
cgttcctcgg cgccgccggg gccccagagg gcagcggcag caacagcagc agcagcagca     60

gcgggagtgg agatggcggc ggcggcggct caggggggcg ggggcgggga gccccgtaga    120

accgaggggg tcggcccggg ggtcccgggg gaggtggaga tggtgaaggg gcagccgttc    180

gacgtgggcc cgcgctacac gcagttgcag tacatcggcg agggcgcgta cggcatggtc    240

agctcggcct atgaccacgt gcgcaagact cgcgtggcca tcaagaagat cagccccttc    300

gaacatcaga cctactgcca gcgcacgctc cgggagatcc agatcctgct gcgcttccgc    360

catgagaatg tcatcggcat ccgagacatt ctgcgggcgt ccaccctgga agccatgaga    420

gatgtctaca ttgtgcagga cctgatggag actgacctgt acaagttgct gaaaagccag    480

cagctgagca atgaccatat ctgctacttc ctctaccaga tcctgcgggg cctcaagtac    540

atccactccg ccaacgtgct ccaccgagat ctaaagccct ccaacctgct cagcaacacc    600

acctgcgacc ttaagatttg tgatttcggc ctggcccgga ttgccgatcc tgagcatgac    660

cacaccggct tcctgacgga gtatgtggct acgcgctggt accgggcccc agagatcatg    720

ctgaactcca agggctatac caagtccatc gacatctggt ctgtgggctg cattctggct    780

gagatgctct ctaaccggcc catcttccct ggcaagcact acctggatca gctcaaccac    840

attctgggca tcctgggctc cccatcccag gaggacctga attgtatcat caacatgaag    900

gcccgaaact acctacagtc tctgccctcc aagaccaagg tggcttgggc caagcttttc    960

cccaagtcag actccaaagc ccttgacctg ctggaccgga tgttaacctt taaccccaat   1020

aaacggatca cagtggagga agcgctggct cacccctacc tggagcagta ctatgacccg   1080

acggatgagc cagtggccga ggagcccttc accttcgcca tggagctgga tgacctacct   1140

aaggagcggc tgaaggagct catcttccag gagacagcac gcttccagcc cggagtgctg   1200

gaggccccct agcccagaca gacatctctg caccctgggg cctggacctg cctcctgcct   1260

gcccctctcc cgccagactg ttagaaaatg gacactgtgc ccagcccgga ccttggcagc   1320

ccaggccggg gtggagcatg ggcctggcca cctctctcct ttgctgaggc ctccagcttc   1380

aggcaggcca aggccttctc ctccccaccc gccctcccca cggggcctcg ggagctcagg   1440

tggccccagt tcaatctccc gctgctgctg ctgctgcgcc cttaccttcc ccagcgtccc   1500

agtctctggc agttctggaa tggaagggtt ctggctgccc caacctgctg aagggcagag   1560

gtggagggtg gggggcgctg agtagggact cagggccatg cctgcccccc tcatctcatt   1620

caaaccccac cctagtttcc ctgaaggaac attccttagt ctcaagggct agcatccctg   1680

aggagccagg ccgggccgaa tcccctccct gtcaaagctg tcacttcgcg tgccctcgct   1740

gcttctgtgt gtggtgagca gaagtggagc tggggggcgt ggagagcccg gcgcccctgc   1800

cacctccctg acccgtctaa tatataaata tagagatgtg tctatggctg aaaaaaaaaa   1860

aaaaaa                                                              1866


<210>  11
<211>  1290
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15      


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30          


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45              


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60                  


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80  


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95      


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110         


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125             


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140                 


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160 


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175     


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190         


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205             


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220                 


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240 


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255     


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270         


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285             


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300                 


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320 


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335     


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350         


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365             


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380                 


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400 


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415     


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430         


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445             


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460                 


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480 


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495     


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510         


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525             


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540                 


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560 


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575     


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590         


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605             


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620                 


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640 


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655     


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670         


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685             


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700                 


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720 


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735     


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750         


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765             


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780                 


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800 


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815     


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830         


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845             


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860                 


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880 


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895     


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910         


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925             


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940                 


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960 


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975     


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990         


Asn Lys Ala Lys Gly Lys Lys Phe  Leu Gln Tyr Asn Arg  Leu Gln Leu 
        995                 1000                 1005             


Ser Arg  Ile Tyr Pro Lys Gly  Gln Arg Leu Asp Ser  Ser Asn Tyr 
    1010                 1015                 1020             


Asp Pro  Leu Pro Met Trp Ile  Cys Gly Ser Gln Leu  Val Ala Leu 
    1025                 1030                 1035             


Asn Phe  Gln Thr Pro Asp Lys  Pro Met Gln Met Asn  Gln Ala Leu 
    1040                 1045                 1050             


Phe Met  Thr Gly Arg His Cys  Gly Tyr Val Leu Gln  Pro Ser Thr 
    1055                 1060                 1065             


Met Arg  Asp Glu Ala Phe Asp  Pro Phe Asp Lys Ser  Ser Leu Arg 
    1070                 1075                 1080             


Gly Leu  Glu Pro Cys Ala Ile  Ser Ile Glu Val Leu  Gly Ala Arg 
    1085                 1090                 1095             


His Leu  Pro Lys Asn Gly Arg  Gly Ile Val Cys Pro  Phe Val Glu 
    1100                 1105                 1110             


Ile Glu  Val Ala Gly Ala Glu  Tyr Asp Ser Thr Lys  Gln Lys Thr 
    1115                 1120                 1125             


Glu Phe  Val Val Asp Asn Gly  Leu Asn Pro Val Trp  Pro Ala Lys 
    1130                 1135                 1140             


Pro Phe  His Phe Gln Ile Ser  Asn Pro Glu Phe Ala  Phe Leu Arg 
    1145                 1150                 1155             


Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser Asp Gln  Asn Phe Leu 
    1160                 1165                 1170             


Ala Gln  Ala Thr Phe Pro Val  Lys Gly Leu Lys Thr  Gly Tyr Arg 
    1175                 1180                 1185             


Ala Val  Pro Leu Lys Asn Asn  Tyr Ser Glu Asp Leu  Glu Leu Ala 
    1190                 1195                 1200             


Ser Leu  Leu Ile Lys Ile Asp  Ile Phe Pro Ala Lys  Glu Asn Gly 
    1205                 1210                 1215             


Asp Leu  Ser Pro Phe Ser Gly  Thr Ser Leu Arg Glu  Arg Gly Ser 
    1220                 1225                 1230             


Asp Ala  Ser Gly Gln Leu Phe  His Gly Arg Ala Arg  Glu Gly Ser 
    1235                 1240                 1245             


Phe Glu  Ser Arg Tyr Gln Gln  Pro Phe Glu Asp Phe  Arg Ile Ser 
    1250                 1255                 1260             


Gln Glu  His Leu Ala Asp His  Phe Asp Ser Arg Glu  Arg Arg Ala 
    1265                 1270                 1275             


Pro Arg  Arg Thr Arg Val Asn  Gly Asp Asn Arg Leu  
    1280                 1285                 1290 


<210>  12
<211>  4408
<212>  DNA
<213>  Homo sapiens

<400>  12
ggggtgccgc cgccgccgtt gcgcttgctc ccgggcggtc ctggcctgtg ccgccgccgc     60

ccccagcgtc ggagccatgg cgggcgccgc gtccccttgc gccaacggct gcgggcccgg    120

cgcgccctcg gacgccgagg tgctgcacct ctgccgcagc ctcgaggtgg gcaccgtcat    180

gactttgttc tactccaaga agtcgcagcg acccgagcgg aagaccttcc aggtcaagct    240

ggagacgcgc cagatcacgt ggagccgggg cgccgacaag atcgaggggg ccattgacat    300

tcgtgaaatt aaggagatcc gcccagggaa gacctcacgg gactttgatc gctatcaaga    360

ggacccagct ttccggccgg accagtcaca ttgctttgtc attctctatg gaatggaatt    420

tcgcctgaaa acgctgagcc tgcaagccac atctgaggat gaagtgaaca tgtggatcaa    480

gggcttaact tggctgatgg aggatacatt gcaggcaccc acacccctgc agattgagag    540

gtggctccgg aagcagtttt actcagtgga tcggaatcgt gaggatcgta tatcagccaa    600

ggacctgaag aacatgctgt cccaggtcaa ctaccgggtc cccaacatgc gcttcctccg    660

agagcggctg acggacctgg agcagcgcag cggggacatc acctacgggc agtttgctca    720

gctgtaccgc agcctcatgt acagcgccca gaagacgatg gacctcccct tcttggaagc    780

cagtactctg agggctgggg agcggccgga gctttgccga gtgtcccttc ctgagttcca    840

gcagttcctt cttgactacc agggggagct gtgggctgtt gatcgcctcc aggtgcagga    900

gttcatgctc agcttcctcc gagacccctt acgagagatc gaggagccat acttcttcct    960

ggatgagttt gtcaccttcc tgttctccaa agagaacagt gtgtggaact cgcagctgga   1020

tgcagtatgc ccggacacca tgaacaaccc tctttcccac tactggatct cctcctcgca   1080

caacacgtac ctgaccgggg accagttctc cagtgagtcc tccttggaag cctatgctcg   1140

ctgcctgcgg atgggctgtc gctgcattga gttggactgc tgggacggcc cggatgggat   1200

gccagttatt taccatgggc acacccttac caccaagatc aagttctcag atgtcctgca   1260

caccatcaag gagcatgcct ttgtggcctc agagtaccca gtcatcctgt ccattgagga   1320

ccactgcagc attgcccagc agagaaacat ggcccaatac ttcaagaagg tgctggggga   1380

cacactcctc accaagcccg tggagatctc tgccgacggg ctcccctcac ccaaccagct   1440

taagaggaag atcctcatca agcacaagaa gctggctgag ggcagtgcct acgaggaggt   1500

gcctacatcc atgatgtact ctgagaacga catcagcaac tctatcaaga atggcatcct   1560

ctacctggag gaccctgtga accacgaatg gtatccccac tactttgttc tgaccagcag   1620

caagatctac tactctgagg agaccagcag tgaccagggc aacgaggatg aggaggagcc   1680

caaggaggtc agcagcagca cagagctgca ctccaatgag aagtggttcc atgggaagct   1740

aggggcaggg cgtgacgggc gtcacatcgc tgagcgcctg cttactgagt actgcatcga   1800

gaccggagcc cctgacggct ccttcctcgt gcgagagagt gagaccttcg tgggcgacta   1860

cacgctctct ttctggcgga acgggaaagt ccagcactgc cgtatccact cccggcaaga   1920

tgctgggacc cccaagttct tcttgacaga caacctcgtc tttgactccc tctatgacct   1980

catcacgcac taccagcagg tgcccctgcg ctgtaatgag tttgagatgc gactttcaga   2040

gcctgtccca cagaccaacg cccacgagag caaagagtgg taccacgcga gcctgaccag   2100

agcacaggct gagcacatgc taatgcgcgt ccctcgtgat ggggccttcc tggtgcggaa   2160

gcggaatgaa cccaactcat atgccatctc tttccgggct gagggcaaga tcaagcattg   2220

ccgtgtccag caagagggcc agacagtgat gctagggaac tcggagttcg acagccttgt   2280

tgacctcatc agctactatg agaaacaccc gctataccgc aagatgaagc tgcgctatcc   2340

catcaacgag gaggcactgg agaagattgg cacagctgag cctgactacg gggccctgta   2400

tgagggacgc aaccctggct tctatgtaga ggcaaaccct atgccaactt tcaagtgtgc   2460

agtcaaagcc ctctttgact acaaggccca gagggaggac gagctgacct tcatcaagag   2520

cgccatcatc cagaatgtgg agaagcaaga gggaggctgg tggcgagggg actacggagg   2580

gaagaagcag ctgtggttcc catcaaacta cgtggaagag atggtcaacc ccgtggccct   2640

ggagccggag agggagcact tggacgagaa cagcccccta ggggacttgc tgcggggggt   2700

cttggatgtg ccggcttgtc agattgccat ccgtcctgag ggcaagaaca accggctctt   2760

cgtcttctcc atcagcatgg cgtcggtggc ccactggtcc ctggatgttg ctgccgactc   2820

acaggaggag ctgcaggact gggtgaaaaa gatccgtgaa gtggcccaga cagcagacgc   2880

caggctcact gaagggaaga taatggaacg gaggaagaag attgccctgg agctctctga   2940

acttgtcgtc tactgccggc ctgttccctt tgatgaagag aagattggca cagaacgtgc   3000

ttgctaccgg gacatgtcat ccttcccgga aaccaaggct gagaaatacg tgaacaaggc   3060

caaaggcaag aagttccttc agtacaatcg actgcagctc tcccgcatct accccaaggg   3120

ccagcgactg gattcctcca actacgatcc tttgcccatg tggatctgtg gcagtcagct   3180

tgtggccctc aacttccaga cccctgacaa gcctatgcag atgaaccagg ccctcttcat   3240

gacgggcagg cactgtggct acgtgctgca gccaagcacc atgcgggatg aggccttcga   3300

cccctttgac aagagcagcc tccgcgggct ggagccatgt gccatctcta ttgaggtgct   3360

gggggcccga catctgccaa agaatggccg aggcattgtg tgtccttttg tggagattga   3420

ggtggctgga gctgagtatg acagcaccaa gcagaagaca gagtttgtgg tggacaatgg   3480

actcaaccct gtatggccag ccaagccctt ccacttccag atcagtaacc ctgaatttgc   3540

ctttctgcgc ttcgtggtgt atgaggaaga catgtttagt gaccagaatt tcctggctca   3600

ggctactttc ccagtaaaag gcctgaagac aggatacaga gcagtgcctt tgaagaacaa   3660

ctacagtgag gacctggagt tggcctccct gctgatcaag attgacattt tccctgccaa   3720

ggagaatggt gacctcagtc ccttcagtgg tacgtccctg cgggagcggg gctcagatgc   3780

ctcaggccag ctgtttcatg gccgagcccg ggaaggctcc tttgaatccc gctaccagca   3840

gccgtttgag gacttccgca tctcccagga gcatctcgca gaccattttg acagtcgaga   3900

acgaagggcc ccaagaagga ctcgggtcaa tggagacaac cgcctctagt tgtaccccag   3960

cctcgttgga gagcagcagg tgctgtgcgc cttgtagaat gccgcgaact gggttctttg   4020

gaagcagccc cctgtggcgg ccttccgggt ctcgcagcct gaagcctgga ttccagcagt   4080

gaatgctaga cagaaaccaa gccattaatg agatgttatt actgttttgg gcctccatgc   4140

cccagctctg gatgaaggca aaaactgtac tgtgtttcgc attaagcaca cacatctggc   4200

cctgacttct ggagatggat ccttccatct tgtggggcca ggaccatggc cgaagcccct   4260

tggagagaga ggctgcctca gccagtggca caggagactc caaggagcta ctgacattcc   4320

taagagtgga ggaggaggag gagccttgct gggccaggga aacaaagttt acattgtcct   4380

gtagctttaa aaccacagct gggcaggg                                      4408


