                         SEQUENCE LISTING

<110>  University of Ottawa
 
<120>  LYSOSOMAL DEGRADATION OF LIPIDS AND PROTEINS AND METHOD OF USE 
       THEREOF

<130>  08930769WO

<140>  PCT/CA2016/000192
<141>  2016-07-08

<150>  US 62/191,274
<151>  2015-07-10

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  2
<211>  875
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu 
1               5                   10                  15      


Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr 
            20                  25                  30          


Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Gly Cys 
        35                  40                  45              


Asn Arg Phe Glu Val Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys 
    50                  55                  60                  


Lys Ile Gln Gln Ile His Val Val Ser Gln Phe Lys Ile Leu Val Ser 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln 
                85                  90                  95      


Ile Thr Thr Val Ser Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp 
            100                 105                 110         


Leu Gln His Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala 
        115                 120                 125             


Val Lys Lys Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His 
    130                 135                 140                 


Glu Leu Gln Gly Asp Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala 
145                 150                 155                 160 


Trp Cys Glu Asn Ser Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu 
                165                 170                 175     


Ile Arg Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly 
            180                 185                 190         


Lys Gln Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala 
        195                 200                 205             


Val Gly Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys 
    210                 215                 220                 


Thr Gln Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu 
225                 230                 235                 240 


His Gln Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile 
                245                 250                 255     


Arg Thr Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg 
            260                 265                 270         


Pro Arg Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser 
        275                 280                 285             


Asn His Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile 
    290                 295                 300                 


Gln Gln Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala 
305                 310                 315                 320 


Glu Met Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His 
                325                 330                 335     


Ile Lys Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp 
            340                 345                 350         


Glu Ser Met Gln Val Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val 
        355                 360                 365             


Met Gly Leu Tyr Pro Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu 
    370                 375                 380                 


Gln Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu 
                405                 410                 415     


Val Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu 
            420                 425                 430         


Met Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile 
        435                 440                 445             


Ile Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu 
    450                 455                 460                 


Val Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu 
465                 470                 475                 480 


Ser Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile 
                485                 490                 495     


Leu Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val 
            500                 505                 510         


Asp Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr 
        515                 520                 525             


Val Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe 
    530                 535                 540                 


Ser Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys 
545                 550                 555                 560 


Ile Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg 
                565                 570                 575     


Val Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr 
            580                 585                 590         


Leu Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His 
        595                 600                 605             


Asn Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly 
625                 630                 635                 640 


Glu Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe 
                645                 650                 655     


Leu Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe 
            660                 665                 670         


Pro Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met 
        675                 680                 685             


Gly Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp 
    690                 695                 700                 


Thr Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys 
705                 710                 715                 720 


Asp Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser 
                725                 730                 735     


Pro Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu 
            740                 745                 750         


Pro Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His 
        755                 760                 765             


Ser Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr 
    770                 775                 780                 


Gln Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn 
785                 790                 795                 800 


Ala Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala 
                805                 810                 815     


Glu Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys 
            820                 825                 830         


Cys Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile 
        835                 840                 845             


Gly Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr 
    850                 855                 860                 


Phe Cys Ser Lys Glu Val Asn Pro Ala Asp Thr 
865                 870                 875 


<210>  3
<211>  854
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15      


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30          


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45              


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60                  


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80  


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95      


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110         


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125             


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140                 


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160 


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175     


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190         


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205             


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220                 


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240 


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255     


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270         


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285             


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300                 


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320 


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335     


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350         


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365             


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380                 


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400 


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415     


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430         


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445             


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460                 


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480 


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495     


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510         


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525             


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540                 


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560 


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575     


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590         


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605             


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620                 


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640 


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655     


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670         


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685             


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700                 


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720 


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735     


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750         


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765             


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780                 


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800 


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815     


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830         


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845             


Ile Leu Glu Met Lys Lys 
    850                 


<210>  4
<211>  829
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15      


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30          


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45              


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60                  


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80  


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95      


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110         


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125             


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140                 


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160 


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175     


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190         


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205             


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220                 


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240 


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255     


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270         


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285             


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300                 


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320 


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335     


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350         


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365             


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380                 


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400 


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415     


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430         


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445             


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460                 


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480 


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495     


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510         


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525             


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540                 


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560 


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575     


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590         


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605             


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620                 


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640 


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655     


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670         


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685             


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700                 


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720 


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735     


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750         


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765             


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780                 


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800 


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815     


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825                 


<210>  5
<211>  941
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Ala Ala Tyr Leu Gln Trp Arg Arg Phe Val Phe Phe Asp Lys Glu 
1               5                   10                  15      


Leu Val Lys Glu Pro Leu Ser Asn Asp Gly Ala Ala Pro Gly Ala Thr 
            20                  25                  30          


Pro Ala Ser Gly Ser Ala Ala Ser Lys Phe Leu Cys Leu Pro Pro Gly 
        35                  40                  45              


Ile Thr Val Cys Asp Ser Gly Arg Gly Ser Leu Val Phe Gly Asp Met 
    50                  55                  60                  


Glu Gly Gln Ile Trp Phe Leu Pro Arg Ser Leu Gln Leu Thr Gly Phe 
65                  70                  75                  80  


Gln Ala Tyr Lys Leu Arg Val Thr His Leu Tyr Gln Leu Lys Gln His 
                85                  90                  95      


Asn Ile Leu Ala Ser Val Gly Glu Asp Glu Glu Gly Ile Asn Pro Leu 
            100                 105                 110         


Val Lys Ile Trp Asn Leu Glu Lys Arg Asp Gly Gly Asn Pro Leu Cys 
        115                 120                 125             


Thr Arg Ile Phe Pro Ala Ile Pro Gly Thr Glu Pro Thr Val Val Ser 
    130                 135                 140                 


Cys Leu Thr Val His Glu Asn Leu Asn Phe Met Ala Ile Gly Phe Thr 
145                 150                 155                 160 


Asp Gly Ser Val Thr Leu Asn Lys Gly Asp Ile Thr Arg Asp Arg His 
                165                 170                 175     


Ser Lys Thr Gln Ile Leu His Lys Gly Asn Tyr Pro Val Thr Gly Leu 
            180                 185                 190         


Ala Phe Arg Gln Ala Gly Lys Thr Thr His Leu Phe Val Val Thr Thr 
        195                 200                 205             


Glu Asn Val Gln Ser Tyr Ile Val Ser Gly Lys Asp Tyr Pro Arg Val 
    210                 215                 220                 


Glu Leu Asp Thr His Gly Cys Gly Leu Arg Cys Ser Ala Leu Ser Asp 
225                 230                 235                 240 


Pro Ser Gln Asp Leu Gln Phe Ile Val Ala Gly Asp Glu Cys Val Tyr 
                245                 250                 255     


Leu Tyr Gln Pro Asp Glu Arg Gly Pro Cys Phe Ala Phe Glu Gly His 
            260                 265                 270         


Lys Leu Ile Ala His Trp Phe Arg Gly Tyr Leu Ile Ile Val Ser Arg 
        275                 280                 285             


Asp Arg Lys Val Ser Pro Lys Ser Glu Phe Thr Ser Arg Asp Ser Gln 
    290                 295                 300                 


Ser Ser Asp Lys Gln Ile Leu Asn Ile Tyr Asp Leu Cys Asn Lys Phe 
305                 310                 315                 320 


Ile Ala Tyr Ser Thr Val Phe Glu Asp Val Val Asp Val Leu Ala Glu 
                325                 330                 335     


Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp Gly Arg Val His Ala Leu 
            340                 345                 350         


Gln Glu Lys Asp Thr Gln Thr Lys Leu Glu Met Leu Phe Lys Lys Asn 
        355                 360                 365             


Leu Phe Glu Met Ala Ile Asn Leu Ala Lys Ser Gln His Leu Asp Ser 
    370                 375                 380                 


Asp Gly Leu Ala Gln Ile Phe Met Gln Tyr Gly Asp His Leu Tyr Ser 
385                 390                 395                 400 


Lys Gly Asn His Asp Gly Ala Val Gln Gln Tyr Ile Arg Thr Ile Gly 
                405                 410                 415     


Lys Leu Glu Pro Ser Tyr Val Ile Arg Lys Phe Leu Asp Ala Gln Arg 
            420                 425                 430         


Ile His Asn Leu Thr Ala Tyr Leu Gln Thr Leu His Arg Gln Ser Leu 
        435                 440                 445             


Ala Asn Ala Asp His Thr Thr Leu Leu Leu Asn Cys Tyr Thr Lys Leu 
    450                 455                 460                 


Lys Asp Ser Ser Lys Leu Glu Glu Phe Ile Lys Lys Lys Ser Glu Ser 
465                 470                 475                 480 


Glu Val His Phe Asp Val Glu Thr Ala Ile Lys Val Leu Arg Gln Ala 
                485                 490                 495     


Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala Glu Asn His Ala His His 
            500                 505                 510         


Glu Trp Tyr Leu Lys Ile Gln Leu Glu Asp Ile Lys Asn Tyr Gln Glu 
        515                 520                 525             


Ala Leu Arg Tyr Ile Gly Lys Leu Pro Phe Glu Gln Ala Glu Ser Asn 
    530                 535                 540                 


Met Lys Arg Tyr Gly Lys Ile Leu Met His His Ile Pro Glu Gln Thr 
545                 550                 555                 560 


Thr Gln Leu Leu Lys Gly Leu Cys Thr Asp Tyr Arg Pro Ser Leu Glu 
                565                 570                 575     


Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys Arg Ala Asn Ser Glu Glu 
            580                 585                 590         


Phe Ile Pro Ile Phe Ala Asn Asn Pro Arg Glu Leu Lys Ala Phe Leu 
        595                 600                 605             


Glu His Met Ser Glu Val Gln Pro Asp Ser Pro Gln Gly Ile Tyr Asp 
    610                 615                 620                 


Thr Leu Leu Glu Leu Arg Leu Gln Asn Trp Ala His Glu Lys Asp Pro 
625                 630                 635                 640 


Gln Val Lys Glu Lys Leu His Ala Glu Ala Ile Ser Leu Leu Lys Ser 
                645                 650                 655     


Gly Arg Phe Cys Asp Val Phe Asp Lys Ala Leu Val Leu Cys Gln Met 
            660                 665                 670         


His Asp Phe Gln Asp Gly Val Leu Tyr Leu Tyr Glu Gln Gly Lys Leu 
        675                 680                 685             


Phe Gln Gln Ile Met His Tyr His Met Gln His Glu Gln Tyr Arg Gln 
    690                 695                 700                 


Val Ile Ser Val Cys Glu Arg His Gly Glu Gln Asp Pro Ser Leu Trp 
705                 710                 715                 720 


Glu Gln Ala Leu Ser Tyr Phe Ala Arg Lys Glu Glu Asp Cys Lys Glu 
                725                 730                 735     


Tyr Val Ala Ala Val Leu Lys His Ile Glu Asn Lys Asn Leu Met Pro 
            740                 745                 750         


Pro Leu Leu Val Val Gln Thr Leu Ala His Asn Ser Thr Ala Thr Leu 
        755                 760                 765             


Ser Val Ile Arg Asp Tyr Leu Val Gln Lys Leu Gln Lys Gln Ser Gln 
    770                 775                 780                 


Gln Ile Ala Gln Asp Glu Leu Arg Val Arg Arg Tyr Arg Glu Glu Thr 
785                 790                 795                 800 


Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu Lys Ala Ser Pro Lys Ile 
                805                 810                 815     


Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn Ser Ala Leu Glu Leu Pro 
            820                 825                 830         


Ser Val His Phe Leu Cys Gly His Ser Phe His Gln His Cys Phe Glu 
        835                 840                 845             


Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro Thr Cys Leu Pro Glu Asn 
    850                 855                 860                 


Arg Lys Val Met Asp Met Ile Arg Ala Gln Glu Gln Lys Arg Asp Leu 
865                 870                 875                 880 


His Asp Gln Phe Gln His Gln Leu Lys Cys Ser Asn Asp Ser Phe Ser 
                885                 890                 895     


Val Ile Ala Asp Tyr Phe Gly Arg Gly Val Phe Asn Lys Leu Thr Leu 
            900                 905                 910         


Leu Thr Asp Pro Pro Thr Ala Arg Leu Thr Ser Ser Leu Glu Ala Gly 
        915                 920                 925             


Leu Gln Arg Asp Leu Leu Met His Ser Arg Arg Gly Thr 
    930                 935                 940     


<210>  6
<211>  931
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Lys Ser Val Cys Arg Arg Gly Pro Cys Arg Ala Pro Leu Trp Phe 
1               5                   10                  15      


Ser Trp Ser Ser Arg Val Val Leu Trp Ser Thr Gly Arg Lys Lys Glu 
            20                  25                  30          


Val His Leu Leu Thr Cys Tyr Gln Leu Ser Asn Pro Gly Arg Leu Leu 
        35                  40                  45              


Asp Tyr Pro Ala His Met Glu Gly Gln Ile Trp Phe Leu Pro Arg Ser 
    50                  55                  60                  


Leu Gln Leu Thr Gly Phe Gln Ala Tyr Lys Leu Arg Val Thr His Leu 
65                  70                  75                  80  


Tyr Gln Leu Lys Gln His Asn Ile Leu Ala Ser Val Gly Glu Asp Glu 
                85                  90                  95      


Glu Gly Ile Asn Pro Leu Val Lys Ile Trp Asn Leu Glu Lys Arg Asp 
            100                 105                 110         


Gly Gly Asn Pro Leu Cys Thr Arg Ile Phe Pro Ala Ile Pro Gly Thr 
        115                 120                 125             


Glu Pro Thr Val Val Ser Cys Leu Thr Val His Glu Asn Leu Asn Phe 
    130                 135                 140                 


Met Ala Ile Gly Phe Thr Asp Gly Ser Val Thr Leu Asn Lys Gly Asp 
145                 150                 155                 160 


Ile Thr Arg Asp Arg His Ser Lys Thr Gln Ile Leu His Lys Gly Asn 
                165                 170                 175     


Tyr Pro Val Thr Gly Leu Ala Phe Arg Gln Ala Gly Lys Thr Thr His 
            180                 185                 190         


Leu Phe Val Val Thr Thr Glu Asn Val Gln Ser Tyr Ile Val Ser Gly 
        195                 200                 205             


Lys Asp Tyr Pro Arg Val Glu Leu Asp Thr His Gly Cys Gly Leu Arg 
    210                 215                 220                 


Cys Ser Ala Leu Ser Asp Pro Ser Gln Asp Leu Gln Phe Ile Val Ala 
225                 230                 235                 240 


Gly Asp Glu Cys Val Tyr Leu Tyr Gln Pro Asp Glu Arg Gly Pro Cys 
                245                 250                 255     


Phe Ala Phe Glu Gly His Lys Leu Ile Ala His Trp Phe Arg Gly Tyr 
            260                 265                 270         


Leu Ile Ile Val Ser Arg Asp Arg Lys Val Ser Pro Lys Ser Glu Phe 
        275                 280                 285             


Thr Ser Arg Asp Ser Gln Ser Ser Asp Lys Gln Ile Leu Asn Ile Tyr 
    290                 295                 300                 


Asp Leu Cys Asn Lys Phe Ile Ala Tyr Ser Thr Val Phe Glu Asp Val 
305                 310                 315                 320 


Val Asp Val Leu Ala Glu Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp 
                325                 330                 335     


Gly Arg Val His Ala Leu Gln Glu Lys Asp Thr Gln Thr Lys Leu Glu 
            340                 345                 350         


Met Leu Phe Lys Lys Asn Leu Phe Glu Met Ala Ile Asn Leu Ala Lys 
        355                 360                 365             


Ser Gln His Leu Asp Ser Asp Gly Leu Ala Gln Ile Phe Met Gln Tyr 
    370                 375                 380                 


Gly Asp His Leu Tyr Ser Lys Gly Asn His Asp Gly Ala Val Gln Gln 
385                 390                 395                 400 


Tyr Ile Arg Thr Ile Gly Lys Leu Glu Pro Ser Tyr Val Ile Arg Lys 
                405                 410                 415     


Phe Leu Asp Ala Gln Arg Ile His Asn Leu Thr Ala Tyr Leu Gln Thr 
            420                 425                 430         


Leu His Arg Gln Ser Leu Ala Asn Ala Asp His Thr Thr Leu Leu Leu 
        435                 440                 445             


Asn Cys Tyr Thr Lys Leu Lys Asp Ser Ser Lys Leu Glu Glu Phe Ile 
    450                 455                 460                 


Lys Lys Lys Ser Glu Ser Glu Val His Phe Asp Val Glu Thr Ala Ile 
465                 470                 475                 480 


Lys Val Leu Arg Gln Ala Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala 
                485                 490                 495     


Glu Asn His Ala His His Glu Trp Tyr Leu Lys Ile Gln Leu Glu Asp 
            500                 505                 510         


Ile Lys Asn Tyr Gln Glu Ala Leu Arg Tyr Ile Gly Lys Leu Pro Phe 
        515                 520                 525             


Glu Gln Ala Glu Ser Asn Met Lys Arg Tyr Gly Lys Ile Leu Met His 
    530                 535                 540                 


His Ile Pro Glu Gln Thr Thr Gln Leu Leu Lys Gly Leu Cys Thr Asp 
545                 550                 555                 560 


Tyr Arg Pro Ser Leu Glu Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys 
                565                 570                 575     


Arg Ala Asn Ser Glu Glu Phe Ile Pro Ile Phe Ala Asn Asn Pro Arg 
            580                 585                 590         


Glu Leu Lys Ala Phe Leu Glu His Met Ser Glu Val Gln Pro Asp Ser 
        595                 600                 605             


Pro Gln Gly Ile Tyr Asp Thr Leu Leu Glu Leu Arg Leu Gln Asn Trp 
    610                 615                 620                 


Ala His Glu Lys Asp Pro Gln Val Lys Glu Lys Leu His Ala Glu Ala 
625                 630                 635                 640 


Ile Ser Leu Leu Lys Ser Gly Arg Phe Cys Asp Val Phe Asp Lys Ala 
                645                 650                 655     


Leu Val Leu Cys Gln Met His Asp Phe Gln Asp Gly Val Leu Tyr Leu 
            660                 665                 670         


Tyr Glu Gln Gly Lys Leu Phe Gln Gln Ile Met His Tyr His Met Gln 
        675                 680                 685             


His Glu Gln Tyr Arg Gln Val Ile Ser Val Cys Glu Arg His Gly Glu 
    690                 695                 700                 


Gln Asp Pro Ser Leu Trp Glu Gln Ala Leu Ser Tyr Phe Ala Arg Lys 
705                 710                 715                 720 


Glu Glu Asp Cys Lys Glu Tyr Val Ala Ala Val Leu Lys His Ile Glu 
                725                 730                 735     


Asn Lys Asn Leu Met Pro Pro Leu Leu Val Val Gln Thr Leu Ala His 
            740                 745                 750         


Asn Ser Thr Ala Thr Leu Ser Val Ile Arg Asp Tyr Leu Val Gln Lys 
        755                 760                 765             


Leu Gln Lys Gln Ser Gln Gln Ile Ala Gln Asp Glu Leu Arg Val Arg 
    770                 775                 780                 


Arg Tyr Arg Glu Glu Thr Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu 
785                 790                 795                 800 


Lys Ala Ser Pro Lys Ile Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn 
                805                 810                 815     


Ser Ala Leu Glu Leu Pro Ser Val His Phe Leu Cys Gly His Ser Phe 
            820                 825                 830         


His Gln His Cys Phe Glu Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro 
        835                 840                 845             


Thr Cys Leu Pro Glu Asn Arg Lys Val Met Asp Met Ile Arg Ala Gln 
    850                 855                 860                 


Glu Gln Lys Arg Asp Leu His Asp Gln Phe Gln His Gln Leu Lys Cys 
865                 870                 875                 880 


Ser Asn Asp Ser Phe Ser Val Ile Ala Asp Tyr Phe Gly Arg Gly Val 
                885                 890                 895     


Phe Asn Lys Leu Thr Leu Leu Thr Asp Pro Pro Thr Ala Arg Leu Thr 
            900                 905                 910         


Ser Ser Leu Glu Ala Gly Leu Gln Arg Asp Leu Leu Met His Ser Arg 
        915                 920                 925             


Arg Gly Thr 
    930     


<210>  7
<211>  854
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15      


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30          


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45              


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60                  


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80  


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95      


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110         


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125             


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140                 


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160 


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175     


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190         


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205             


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220                 


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240 


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255     


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270         


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285             


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300                 


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320 


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335     


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350         


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365             


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380                 


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400 


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415     


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430         


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445             


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460                 


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480 


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495     


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510         


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525             


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540                 


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560 


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575     


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590         


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605             


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620                 


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640 


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655     


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670         


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685             


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700                 


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720 


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735     


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750         


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765             


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780                 


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800 


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815     


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830         


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845             


Ile Leu Glu Met Lys Lys 
    850                 


<210>  8
<211>  829
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15      


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30          


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45              


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60                  


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80  


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95      


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110         


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125             


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140                 


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160 


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175     


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190         


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205             


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220                 


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240 


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255     


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270         


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285             


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300                 


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320 


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335     


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350         


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365             


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380                 


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400 


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415     


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430         


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445             


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460                 


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480 


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495     


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510         


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525             


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540                 


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560 


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575     


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590         


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605             


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620                 


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640 


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655     


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670         


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685             


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700                 


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720 


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735     


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750         


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765             


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780                 


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800 


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815     


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825                 


<210>  9
<211>  941
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Ala Ala Tyr Leu Gln Trp Arg Arg Phe Val Phe Phe Asp Lys Glu 
1               5                   10                  15      


Leu Val Lys Glu Pro Leu Ser Asn Asp Gly Ala Ala Pro Gly Ala Thr 
            20                  25                  30          


Pro Ala Ser Gly Ser Ala Ala Ser Lys Phe Leu Cys Leu Pro Pro Gly 
        35                  40                  45              


Ile Thr Val Cys Asp Ser Gly Arg Gly Ser Leu Val Phe Gly Asp Met 
    50                  55                  60                  


Glu Gly Gln Ile Trp Phe Leu Pro Arg Ser Leu Gln Leu Thr Gly Phe 
65                  70                  75                  80  


Gln Ala Tyr Lys Leu Arg Val Thr His Leu Tyr Gln Leu Lys Gln His 
                85                  90                  95      


Asn Ile Leu Ala Ser Val Gly Glu Asp Glu Glu Gly Ile Asn Pro Leu 
            100                 105                 110         


Val Lys Ile Trp Asn Leu Glu Lys Arg Asp Gly Gly Asn Pro Leu Cys 
        115                 120                 125             


Thr Arg Ile Phe Pro Ala Ile Pro Gly Thr Glu Pro Thr Val Val Ser 
    130                 135                 140                 


Cys Leu Thr Val His Glu Asn Leu Asn Phe Met Ala Ile Gly Phe Thr 
145                 150                 155                 160 


Asp Gly Ser Val Thr Leu Asn Lys Gly Asp Ile Thr Arg Asp Arg His 
                165                 170                 175     


Ser Lys Thr Gln Ile Leu His Lys Gly Asn Tyr Pro Val Thr Gly Leu 
            180                 185                 190         


Ala Phe Arg Gln Ala Gly Lys Thr Thr His Leu Phe Val Val Thr Thr 
        195                 200                 205             


Glu Asn Val Gln Ser Tyr Ile Val Ser Gly Lys Asp Tyr Pro Arg Val 
    210                 215                 220                 


Glu Leu Asp Thr His Gly Cys Gly Leu Arg Cys Ser Ala Leu Ser Asp 
225                 230                 235                 240 


Pro Ser Gln Asp Leu Gln Phe Ile Val Ala Gly Asp Glu Cys Val Tyr 
                245                 250                 255     


Leu Tyr Gln Pro Asp Glu Arg Gly Pro Cys Phe Ala Phe Glu Gly His 
            260                 265                 270         


Lys Leu Ile Ala His Trp Phe Arg Gly Tyr Leu Ile Ile Val Ser Arg 
        275                 280                 285             


Asp Arg Lys Val Ser Pro Lys Ser Glu Phe Thr Ser Arg Asp Ser Gln 
    290                 295                 300                 


Ser Ser Asp Lys Gln Ile Leu Asn Ile Tyr Asp Leu Cys Asn Lys Phe 
305                 310                 315                 320 


Ile Ala Tyr Ser Thr Val Phe Glu Asp Val Val Asp Val Leu Ala Glu 
                325                 330                 335     


Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp Gly Arg Val His Ala Leu 
            340                 345                 350         


Gln Glu Lys Asp Thr Gln Thr Lys Leu Glu Met Leu Phe Lys Lys Asn 
        355                 360                 365             


Leu Phe Glu Met Ala Ile Asn Leu Ala Lys Ser Gln His Leu Asp Ser 
    370                 375                 380                 


Asp Gly Leu Ala Gln Ile Phe Met Gln Tyr Gly Asp His Leu Tyr Ser 
385                 390                 395                 400 


Lys Gly Asn His Asp Gly Ala Val Gln Gln Tyr Ile Arg Thr Ile Gly 
                405                 410                 415     


Lys Leu Glu Pro Ser Tyr Val Ile Arg Lys Phe Leu Asp Ala Gln Arg 
            420                 425                 430         


Ile His Asn Leu Thr Ala Tyr Leu Gln Thr Leu His Arg Gln Ser Leu 
        435                 440                 445             


Ala Asn Ala Asp His Thr Thr Leu Leu Leu Asn Cys Tyr Thr Lys Leu 
    450                 455                 460                 


Lys Asp Ser Ser Lys Leu Glu Glu Phe Ile Lys Lys Lys Ser Glu Ser 
465                 470                 475                 480 


Glu Val His Phe Asp Val Glu Thr Ala Ile Lys Val Leu Arg Gln Ala 
                485                 490                 495     


Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala Glu Asn His Ala His His 
            500                 505                 510         


Glu Trp Tyr Leu Lys Ile Gln Leu Glu Asp Ile Lys Asn Tyr Gln Glu 
        515                 520                 525             


Ala Leu Arg Tyr Ile Gly Lys Leu Pro Phe Glu Gln Ala Glu Ser Asn 
    530                 535                 540                 


Met Lys Arg Tyr Gly Lys Ile Leu Met His His Ile Pro Glu Gln Thr 
545                 550                 555                 560 


Thr Gln Leu Leu Lys Gly Leu Cys Thr Asp Tyr Arg Pro Ser Leu Glu 
                565                 570                 575     


Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys Arg Ala Asn Ser Glu Glu 
            580                 585                 590         


Phe Ile Pro Ile Phe Ala Asn Asn Pro Arg Glu Leu Lys Ala Phe Leu 
        595                 600                 605             


Glu His Met Ser Glu Val Gln Pro Asp Ser Pro Gln Gly Ile Tyr Asp 
    610                 615                 620                 


Thr Leu Leu Glu Leu Arg Leu Gln Asn Trp Ala His Glu Lys Asp Pro 
625                 630                 635                 640 


Gln Val Lys Glu Lys Leu His Ala Glu Ala Ile Ser Leu Leu Lys Ser 
                645                 650                 655     


Gly Arg Phe Cys Asp Val Phe Asp Lys Ala Leu Val Leu Cys Gln Met 
            660                 665                 670         


His Asp Phe Gln Asp Gly Val Leu Tyr Leu Tyr Glu Gln Gly Lys Leu 
        675                 680                 685             


Phe Gln Gln Ile Met His Tyr His Met Gln His Glu Gln Tyr Arg Gln 
    690                 695                 700                 


Val Ile Ser Val Cys Glu Arg His Gly Glu Gln Asp Pro Ser Leu Trp 
705                 710                 715                 720 


Glu Gln Ala Leu Ser Tyr Phe Ala Arg Lys Glu Glu Asp Cys Lys Glu 
                725                 730                 735     


Tyr Val Ala Ala Val Leu Lys His Ile Glu Asn Lys Asn Leu Met Pro 
            740                 745                 750         


Pro Leu Leu Val Val Gln Thr Leu Ala His Asn Ser Thr Ala Thr Leu 
        755                 760                 765             


Ser Val Ile Arg Asp Tyr Leu Val Gln Lys Leu Gln Lys Gln Ser Gln 
    770                 775                 780                 


Gln Ile Ala Gln Asp Glu Leu Arg Val Arg Arg Tyr Arg Glu Glu Thr 
785                 790                 795                 800 


Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu Lys Ala Ser Pro Lys Ile 
                805                 810                 815     


Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn Ser Ala Leu Glu Leu Pro 
            820                 825                 830         


Ser Val His Phe Leu Cys Gly His Ser Phe His Gln His Cys Phe Glu 
        835                 840                 845             


Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro Thr Cys Leu Pro Glu Asn 
    850                 855                 860                 


Arg Lys Val Met Asp Met Ile Arg Ala Gln Glu Gln Lys Arg Asp Leu 
865                 870                 875                 880 


His Asp Gln Phe Gln His Gln Leu Lys Cys Ser Asn Asp Ser Phe Ser 
                885                 890                 895     


Val Ile Ala Asp Tyr Phe Gly Arg Gly Val Phe Asn Lys Leu Thr Leu 
            900                 905                 910         


Leu Thr Asp Pro Pro Thr Ala Arg Leu Thr Ser Ser Leu Glu Ala Gly 
        915                 920                 925             


Leu Gln Arg Asp Leu Leu Met His Ser Arg Arg Gly Thr 
    930                 935                 940     


<210>  10
<211>  931
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Lys Ser Val Cys Arg Arg Gly Pro Cys Arg Ala Pro Leu Trp Phe 
1               5                   10                  15      


Ser Trp Ser Ser Arg Val Val Leu Trp Ser Thr Gly Arg Lys Lys Glu 
            20                  25                  30          


Val His Leu Leu Thr Cys Tyr Gln Leu Ser Asn Pro Gly Arg Leu Leu 
        35                  40                  45              


Asp Tyr Pro Ala His Met Glu Gly Gln Ile Trp Phe Leu Pro Arg Ser 
    50                  55                  60                  


Leu Gln Leu Thr Gly Phe Gln Ala Tyr Lys Leu Arg Val Thr His Leu 
65                  70                  75                  80  


Tyr Gln Leu Lys Gln His Asn Ile Leu Ala Ser Val Gly Glu Asp Glu 
                85                  90                  95      


Glu Gly Ile Asn Pro Leu Val Lys Ile Trp Asn Leu Glu Lys Arg Asp 
            100                 105                 110         


Gly Gly Asn Pro Leu Cys Thr Arg Ile Phe Pro Ala Ile Pro Gly Thr 
        115                 120                 125             


Glu Pro Thr Val Val Ser Cys Leu Thr Val His Glu Asn Leu Asn Phe 
    130                 135                 140                 


Met Ala Ile Gly Phe Thr Asp Gly Ser Val Thr Leu Asn Lys Gly Asp 
145                 150                 155                 160 


Ile Thr Arg Asp Arg His Ser Lys Thr Gln Ile Leu His Lys Gly Asn 
                165                 170                 175     


Tyr Pro Val Thr Gly Leu Ala Phe Arg Gln Ala Gly Lys Thr Thr His 
            180                 185                 190         


Leu Phe Val Val Thr Thr Glu Asn Val Gln Ser Tyr Ile Val Ser Gly 
        195                 200                 205             


Lys Asp Tyr Pro Arg Val Glu Leu Asp Thr His Gly Cys Gly Leu Arg 
    210                 215                 220                 


Cys Ser Ala Leu Ser Asp Pro Ser Gln Asp Leu Gln Phe Ile Val Ala 
225                 230                 235                 240 


Gly Asp Glu Cys Val Tyr Leu Tyr Gln Pro Asp Glu Arg Gly Pro Cys 
                245                 250                 255     


Phe Ala Phe Glu Gly His Lys Leu Ile Ala His Trp Phe Arg Gly Tyr 
            260                 265                 270         


Leu Ile Ile Val Ser Arg Asp Arg Lys Val Ser Pro Lys Ser Glu Phe 
        275                 280                 285             


Thr Ser Arg Asp Ser Gln Ser Ser Asp Lys Gln Ile Leu Asn Ile Tyr 
    290                 295                 300                 


Asp Leu Cys Asn Lys Phe Ile Ala Tyr Ser Thr Val Phe Glu Asp Val 
305                 310                 315                 320 


Val Asp Val Leu Ala Glu Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp 
                325                 330                 335     


Gly Arg Val His Ala Leu Gln Glu Lys Asp Thr Gln Thr Lys Leu Glu 
            340                 345                 350         


Met Leu Phe Lys Lys Asn Leu Phe Glu Met Ala Ile Asn Leu Ala Lys 
        355                 360                 365             


Ser Gln His Leu Asp Ser Asp Gly Leu Ala Gln Ile Phe Met Gln Tyr 
    370                 375                 380                 


Gly Asp His Leu Tyr Ser Lys Gly Asn His Asp Gly Ala Val Gln Gln 
385                 390                 395                 400 


Tyr Ile Arg Thr Ile Gly Lys Leu Glu Pro Ser Tyr Val Ile Arg Lys 
                405                 410                 415     


Phe Leu Asp Ala Gln Arg Ile His Asn Leu Thr Ala Tyr Leu Gln Thr 
            420                 425                 430         


Leu His Arg Gln Ser Leu Ala Asn Ala Asp His Thr Thr Leu Leu Leu 
        435                 440                 445             


Asn Cys Tyr Thr Lys Leu Lys Asp Ser Ser Lys Leu Glu Glu Phe Ile 
    450                 455                 460                 


Lys Lys Lys Ser Glu Ser Glu Val His Phe Asp Val Glu Thr Ala Ile 
465                 470                 475                 480 


Lys Val Leu Arg Gln Ala Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala 
                485                 490                 495     


Glu Asn His Ala His His Glu Trp Tyr Leu Lys Ile Gln Leu Glu Asp 
            500                 505                 510         


Ile Lys Asn Tyr Gln Glu Ala Leu Arg Tyr Ile Gly Lys Leu Pro Phe 
        515                 520                 525             


Glu Gln Ala Glu Ser Asn Met Lys Arg Tyr Gly Lys Ile Leu Met His 
    530                 535                 540                 


His Ile Pro Glu Gln Thr Thr Gln Leu Leu Lys Gly Leu Cys Thr Asp 
545                 550                 555                 560 


Tyr Arg Pro Ser Leu Glu Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys 
                565                 570                 575     


Arg Ala Asn Ser Glu Glu Phe Ile Pro Ile Phe Ala Asn Asn Pro Arg 
            580                 585                 590         


Glu Leu Lys Ala Phe Leu Glu His Met Ser Glu Val Gln Pro Asp Ser 
        595                 600                 605             


Pro Gln Gly Ile Tyr Asp Thr Leu Leu Glu Leu Arg Leu Gln Asn Trp 
    610                 615                 620                 


Ala His Glu Lys Asp Pro Gln Val Lys Glu Lys Leu His Ala Glu Ala 
625                 630                 635                 640 


Ile Ser Leu Leu Lys Ser Gly Arg Phe Cys Asp Val Phe Asp Lys Ala 
                645                 650                 655     


Leu Val Leu Cys Gln Met His Asp Phe Gln Asp Gly Val Leu Tyr Leu 
            660                 665                 670         


Tyr Glu Gln Gly Lys Leu Phe Gln Gln Ile Met His Tyr His Met Gln 
        675                 680                 685             


His Glu Gln Tyr Arg Gln Val Ile Ser Val Cys Glu Arg His Gly Glu 
    690                 695                 700                 


Gln Asp Pro Ser Leu Trp Glu Gln Ala Leu Ser Tyr Phe Ala Arg Lys 
705                 710                 715                 720 


Glu Glu Asp Cys Lys Glu Tyr Val Ala Ala Val Leu Lys His Ile Glu 
                725                 730                 735     


Asn Lys Asn Leu Met Pro Pro Leu Leu Val Val Gln Thr Leu Ala His 
            740                 745                 750         


Asn Ser Thr Ala Thr Leu Ser Val Ile Arg Asp Tyr Leu Val Gln Lys 
        755                 760                 765             


Leu Gln Lys Gln Ser Gln Gln Ile Ala Gln Asp Glu Leu Arg Val Arg 
    770                 775                 780                 


Arg Tyr Arg Glu Glu Thr Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu 
785                 790                 795                 800 


Lys Ala Ser Pro Lys Ile Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn 
                805                 810                 815     


Ser Ala Leu Glu Leu Pro Ser Val His Phe Leu Cys Gly His Ser Phe 
            820                 825                 830         


His Gln His Cys Phe Glu Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro 
        835                 840                 845             


Thr Cys Leu Pro Glu Asn Arg Lys Val Met Asp Met Ile Arg Ala Gln 
    850                 855                 860                 


Glu Gln Lys Arg Asp Leu His Asp Gln Phe Gln His Gln Leu Lys Cys 
865                 870                 875                 880 


Ser Asn Asp Ser Phe Ser Val Ile Ala Asp Tyr Phe Gly Arg Gly Val 
                885                 890                 895     


Phe Asn Lys Leu Thr Leu Leu Thr Asp Pro Pro Thr Ala Arg Leu Thr 
            900                 905                 910         


Ser Ser Leu Glu Ala Gly Leu Gln Arg Asp Leu Leu Met His Ser Arg 
        915                 920                 925             


Arg Gly Thr 
    930     


<210>  11
<211>  875
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu 
1               5                   10                  15      


Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr 
            20                  25                  30          


Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Gly Cys 
        35                  40                  45              


Asn Arg Phe Glu Val Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys 
    50                  55                  60                  


Lys Ile Gln Gln Ile His Val Val Ser Gln Phe Lys Ile Leu Val Ser 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln 
                85                  90                  95      


Ile Thr Thr Val Ser Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp 
            100                 105                 110         


Leu Gln His Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala 
        115                 120                 125             


Val Lys Lys Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His 
    130                 135                 140                 


Glu Leu Gln Gly Asp Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala 
145                 150                 155                 160 


Trp Cys Glu Asn Ser Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu 
                165                 170                 175     


Ile Arg Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly 
            180                 185                 190         


Lys Gln Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala 
        195                 200                 205             


Val Gly Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys 
    210                 215                 220                 


Thr Gln Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu 
225                 230                 235                 240 


His Gln Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile 
                245                 250                 255     


Arg Thr Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg 
            260                 265                 270         


Pro Arg Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser 
        275                 280                 285             


Asn His Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile 
    290                 295                 300                 


Gln Gln Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala 
305                 310                 315                 320 


Glu Met Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His 
                325                 330                 335     


Ile Lys Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp 
            340                 345                 350         


Glu Ser Met Gln Val Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val 
        355                 360                 365             


Met Gly Leu Tyr Pro Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu 
    370                 375                 380                 


Gln Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu 
                405                 410                 415     


Val Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu 
            420                 425                 430         


Met Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile 
        435                 440                 445             


Ile Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu 
    450                 455                 460                 


Val Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu 
465                 470                 475                 480 


Ser Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile 
                485                 490                 495     


Leu Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val 
            500                 505                 510         


Asp Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr 
        515                 520                 525             


Val Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe 
    530                 535                 540                 


Ser Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys 
545                 550                 555                 560 


Ile Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg 
                565                 570                 575     


Val Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr 
            580                 585                 590         


Leu Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His 
        595                 600                 605             


Asn Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly 
625                 630                 635                 640 


Glu Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe 
                645                 650                 655     


Leu Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe 
            660                 665                 670         


Pro Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met 
        675                 680                 685             


Gly Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp 
    690                 695                 700                 


Thr Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys 
705                 710                 715                 720 


Asp Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser 
                725                 730                 735     


Pro Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu 
            740                 745                 750         


Pro Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His 
        755                 760                 765             


Ser Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr 
    770                 775                 780                 


Gln Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn 
785                 790                 795                 800 


Ala Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala 
                805                 810                 815     


Glu Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys 
            820                 825                 830         


Cys Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile 
        835                 840                 845             


Gly Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr 
    850                 855                 860                 


Phe Cys Ser Lys Glu Val Asn Pro Ala Asp Thr 
865                 870                 875 


<210>  12
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T34N substitution, GDP-binding

<400>  12

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Asn Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  13
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q75L substitution, GTP-binding

<400>  13

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Leu Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  14
<211>  1327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP labelled Arl8bWT

<400>  14
ttccccaaat tataggagca gagctctctg gctactagag aacccactgc ttactggctt       60

atcgaaatta atacgactca ctatagggag acccaagctg gctagttaag cttggtaccg      120

agctcggatc cactagtcca gtgtggtgga attgcccttc accatgctgg cgctcatctc      180

ccgcctgctg gactggttcc gttcgctctt ctggaaggaa gagatggagc tgacgctcgt      240

ggggctgcag tactcgggca agaccacctt cgtcaatgtc atcgcgtcag gtcaattcag      300

tgaagatatg atacccacag tgggcttcaa catgaggaag gtaactaaag gtaacgtcac      360

aataaagatc tgggacatag gaggacaacc ccgatttcga agcatgtggg agcggtattg      420

cagaggagtc aatgctattg tttacatgat agatgctgca gatcgtgaaa agatagaagc      480

ttcccgaaat gagctacata atcttctaga taaaccacag ttacaaggaa ttccagtgct      540

agtgcttgga aacaagagag atcttcctaa tgccttggat gagaaacagc taattgaaaa      600

aatgaatctg tctgctattc aggatagaga aatttgctgc tattcaattt cttgcaaaga      660

aaaggataat atagatatca cacttcagtg gcttattcag cattcaaaat ctagaagaag      720

cgaagggcaa ttctgcagat atccagcaca gtggcggccg ctcgagtcta gaatggctag      780

caaaggagaa gaacttttca ctggagttgt cccaattctt gtttgaatta gatggtgatg      840

ttaatgggca caaattttct gtcagtggag agggtgaagg tgaatgctac atacggaaag      900

cttaccctta aatttatttt gcactactgg aaaactacct gttccatggg ccaatacttg      960

tcactacttt ctcttatgtt gtccatgctt tttcccgtta tccggataat atgaaacggc     1020

atgacttttc cagagtgcca tggcccgaag ggttatgttc taggaacgca cttatatctt     1080

tcaagatgac gggaactaac aagaacccgt gctgaagtca agtttgaagg ggataccttg     1140

gtttatcgta cgagtttaaa gggtattgat tttaaagaaa taggaatacc atcctccgga     1200

ctcctacttc tgtagttcca ctctattacc tccccaccat tgtgttatat tccatgtgcc     1260

ggctcaccaa gtgaatggta ttactaagct aatactctca tcaatcttcc tccaccaaca     1320

cactgag                                                               1327


<210>  15
<211>  1250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcherry labelled Arl8bWT

<400>  15
cacccaagac aaaagcagag ctggtttagt gaccgtcaga tccgctagcg ctaccggact       60

cagatctcga gatgctggcg ctcatctccc gcctgctgga ctggttccgt tcgctcttct      120

ggaaggaaga gatggagctg acgctcgtgg ggctgcagta ctcgggcaag accaccttcg      180

tcaatgtcat cgcgtcaggt caattcagtg aagatatgat acccacagtg ggcttcaaca      240

tgaggaaggt aactaaaggt aacgtcacaa taaagatctg ggacatagga ggacaacccc      300

gatttcgaag catgtgggag cggtattgca gaggagtcaa tgctattgtt tacatgatag      360

atgctgcaga tcgtgaaaag atagaagctt cccgaaatga gctacataat cttctagata      420

aaccacagtt acaaggaatt ccagtgctag tgcttggaaa caagagagat cttcctaatg      480

ccttggatga gaaacagcta attgaaaaaa tgaatctgtc tgctattcag gatagagaaa      540

tttgctgcta ttcaatttct tgcaaagaaa aggataatat agatatcaca cttcagtggc      600

ttattcagca ttcaaaatct agaagaagcc gggatccgat ggtgagcaag ggcgaggagg      660

ataacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag ggctccgtga      720

acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag ggcacccaga      780

ccgccaagct gaaggtgacc aagggtggcc ccctgccctt cgcctgggac atcctgtccc      840

ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc cccgactact      900

tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc gaggacggcg      960

gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc tacaagtgaa     1020

gctgcgcggc accaacttcc cctccgacgg ccccgtaatg cagaagagga ccatgggctg     1080

gaggcctcct cgagcgatgt accccgagga cgcgccctga ggcgagatca gcagaggctg     1140

agctgagacg ccgccactac gacgctgagt cagaactact acaagtcaga gccggcagct     1200

gctggcctac acgtcacttc agtggaactt aacttcacaa agcgaggaac                1250


<210>  16
<211>  1193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcherry labelled Arl8bQ75L

<400>  16
tttcaacgga atacaaatag cgagctggtt tagtgaccgt cagatccgct agcgctaccg       60

gactcagatc tcgagatgct ggcgctcatc tcccgcctgc tggactggtt ccgttcgctc      120

ttctggaagg aagagatgga gctgacgctc gtggggctgc agtactcggg caagaccacc      180

ttcgtcaatg tcatcgcgtc aggtcaattc agtgaagata tgatacccac agtgggcttc      240

aacatgagga aggtaactaa aggtaacgtc acaataaaga tctgggacat aggaggacta      300

ccccgatttc gaagcatgtg ggagcggtat tgcagaggag tcaatgctat tgtttacatg      360

atagatgctg cagatcgtga aaagatagaa gcttcccgaa atgagctaca taatcttcta      420

gataaaccac agttacaagg aattccagtg ctagtgcttg gaaacaagag agatcttcct      480

aatgccttgg atgagaaaca gctaattgaa aaaatgaatc tgtctgctat tcaggataga      540

gaaatttgct gctattcaat ttcttgcaaa gaaaaggata atatagatat cacacttcag      600

tggcttattc agcattcaaa atctagaaga agccgggatc cgatggtgag caagggcgag      660

gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc      720

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc      780

cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg      840

tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac      900

tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac      960

ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacagt     1020

gaagctgcgc ggcaccaact tcccctccga cgctcgtatg cagagagaca tgggctggga     1080

gctctcgagc gatgtacccg agacgcgcct gaggcgagat cagcagagct gagctgagga     1140

cgcgcactac gacgctgaag tcagacacta cagtcagaag ccgttcagct gcc            1193


<210>  17
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcherry labelled Arl8bT34N

<400>  17
ataaccccaa tacaaaagca gagctggttt agtgaccgtc agatccgcta gcgctaccgg       60

actcagatct cgagatgctg gcgctcatct cccgcctgct ggactggttc cgttcgctct      120

tctggaagga agagatggag ctgacgctcg tggggctgca gtactcgggc aagaacacct      180

tcgtcaatgt catcgcgtca ggtcaattca gtgaagatat gatacccaca gtgggcttca      240

acatgaggaa ggtaactaaa ggtaacgtca caataaagat ctgggacata ggaggacaac      300

cccgatttcg aagcatgtgg gagcggtatt gcagaggagt caatgctatt gtttacatga      360

tagatgctgc agatcgtgaa aagatagaag cttcccgaaa tgagctacat aatcttctag      420

ataaaccaca gttacaagga attccagtgc tagtgcttgg aaacaagaga gatcttccta      480

atgccttgga tgagaaacag ctaattgaaa agatgaatct gtctgctatt caggatagag      540

aaatttgctg ctattcaatt tcttgcaaag aaaaggataa tatagatatc acacttcagt      600

ggcttattca gcattcaaaa tctagaagaa gccgggatcc gatggtgagc aagggcgagg      660

aggataacat ggccatcatc aaggagttca tgcgcttcaa ggtgcacatg gagggctccg      720

tgaacggcca cgagttcgag atcgagggcg agggcgaggg ccgcccctac gagggcaccc      780

agaccgccaa gctgaaggtg accaagggtg gccccctgcc cttcgcctgg gacatcctgt      840

cccctcagtt catgtacggc tccaaggcct acgtgaagca ccccgccgac atccccgact      900

acttgaagct gtccttcccc gagggcttca agtgggagcg cgtgatgaac ttccaggacg      960

gcggcgtggt gaccgtgacc caggacttcc tcccctgcag gacggcgagt tcatctacaa     1020

agtgaagctg cgcgggcacc aacttccccc tccgacggcc ccgtaatgca gaagaaagac     1080

catgggcctg gaaggccttc ctcgagcgat gttacccgaa gacggcgtcc ctgaaaggcg     1140

agatatcagc atgaagctga agcttgaaga tcggcgtcac ttacgtactg ccttgagtca     1200

tagaccaact tacaagccat agaagtcggt gcagcttgtc ctgtccttta cacatgctct     1260

ataactatct aagtttggaa acattcacta cggtctacac agcaggatga c              1311


<210>  18
<211>  1250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MG1021 vector

<400>  18
cacccaagac aaaagcagag ctggtttagt gaccgtcaga tccgctagcg ctaccggact       60

cagatctcga gatgctggcg ctcatctccc gcctgctgga ctggttccgt tcgctcttct      120

ggaaggaaga gatggagctg acgctcgtgg ggctgcagta ctcgggcaag accaccttcg      180

tcaatgtcat cgcgtcaggt caattcagtg aagatatgat acccacagtg ggcttcaaca      240

tgaggaaggt aactaaaggt aacgtcacaa taaagatctg ggacatagga ggacaacccc      300

gatttcgaag catgtgggag cggtattgca gaggagtcaa tgctattgtt tacatgatag      360

atgctgcaga tcgtgaaaag atagaagctt cccgaaatga gctacataat cttctagata      420

aaccacagtt acaaggaatt ccagtgctag tgcttggaaa caagagagat cttcctaatg      480

ccttggatga gaaacagcta attgaaaaaa tgaatctgtc tgctattcag gatagagaaa      540

tttgctgcta ttcaatttct tgcaaagaaa aggataatat agatatcaca cttcagtggc      600

ttattcagca ttcaaaatct agaagaagcc gggatccgat ggtgagcaag ggcgaggagg      660

ataacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag ggctccgtga      720

acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag ggcacccaga      780

ccgccaagct gaaggtgacc aagggtggcc ccctgccctt cgcctgggac atcctgtccc      840

ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc cccgactact      900

tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc gaggacggcg      960

gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc tacaagtgaa     1020

gctgcgcggc accaacttcc cctccgacgg ccccgtaatg cagaagagga ccatgggctg     1080

gaggcctcct cgagcgatgt accccgagga cgcgccctga ggcgagatca gcagaggctg     1140

agctgagacg ccgccactac gacgctgagt cagaactact acaagtcaga gccggcagct     1200

gctggcctac acgtcacttc agtggaactt aacttcacaa agcgaggaac                1250


<210>  19
<211>  1193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MG1022 vector

<400>  19
tttcaacgga atacaaatag cgagctggtt tagtgaccgt cagatccgct agcgctaccg       60

gactcagatc tcgagatgct ggcgctcatc tcccgcctgc tggactggtt ccgttcgctc      120

ttctggaagg aagagatgga gctgacgctc gtggggctgc agtactcggg caagaccacc      180

ttcgtcaatg tcatcgcgtc aggtcaattc agtgaagata tgatacccac agtgggcttc      240

aacatgagga aggtaactaa aggtaacgtc acaataaaga tctgggacat aggaggacta      300

ccccgatttc gaagcatgtg ggagcggtat tgcagaggag tcaatgctat tgtttacatg      360

atagatgctg cagatcgtga aaagatagaa gcttcccgaa atgagctaca taatcttcta      420

gataaaccac agttacaagg aattccagtg ctagtgcttg gaaacaagag agatcttcct      480

aatgccttgg atgagaaaca gctaattgaa aaaatgaatc tgtctgctat tcaggataga      540

gaaatttgct gctattcaat ttcttgcaaa gaaaaggata atatagatat cacacttcag      600

tggcttattc agcattcaaa atctagaaga agccgggatc cgatggtgag caagggcgag      660

gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc      720

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc      780

cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg      840

tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac      900

tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac      960

ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacagt     1020

gaagctgcgc ggcaccaact tcccctccga cgctcgtatg cagagagaca tgggctggga     1080

gctctcgagc gatgtacccg agacgcgcct gaggcgagat cagcagagct gagctgagga     1140

cgcgcactac gacgctgaag tcagacacta cagtcagaag ccgttcagct gcc            1193


<210>  20
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MG1023 vector

<400>  20
ataaccccaa tacaaaagca gagctggttt agtgaccgtc agatccgcta gcgctaccgg       60

actcagatct cgagatgctg gcgctcatct cccgcctgct ggactggttc cgttcgctct      120

tctggaagga agagatggag ctgacgctcg tggggctgca gtactcgggc aagaacacct      180

tcgtcaatgt catcgcgtca ggtcaattca gtgaagatat gatacccaca gtgggcttca      240

acatgaggaa ggtaactaaa ggtaacgtca caataaagat ctgggacata ggaggacaac      300

cccgatttcg aagcatgtgg gagcggtatt gcagaggagt caatgctatt gtttacatga      360

tagatgctgc agatcgtgaa aagatagaag cttcccgaaa tgagctacat aatcttctag      420

ataaaccaca gttacaagga attccagtgc tagtgcttgg aaacaagaga gatcttccta      480

atgccttgga tgagaaacag ctaattgaaa agatgaatct gtctgctatt caggatagag      540

aaatttgctg ctattcaatt tcttgcaaag aaaaggataa tatagatatc acacttcagt      600

ggcttattca gcattcaaaa tctagaagaa gccgggatcc gatggtgagc aagggcgagg      660

aggataacat ggccatcatc aaggagttca tgcgcttcaa ggtgcacatg gagggctccg      720

tgaacggcca cgagttcgag atcgagggcg agggcgaggg ccgcccctac gagggcaccc      780

agaccgccaa gctgaaggtg accaagggtg gccccctgcc cttcgcctgg gacatcctgt      840

cccctcagtt catgtacggc tccaaggcct acgtgaagca ccccgccgac atccccgact      900

acttgaagct gtccttcccc gagggcttca agtgggagcg cgtgatgaac ttccaggacg      960

gcggcgtggt gaccgtgacc caggacttcc tcccctgcag gacggcgagt tcatctacaa     1020

agtgaagctg cgcgggcacc aacttccccc tccgacggcc ccgtaatgca gaagaaagac     1080

catgggcctg gaaggccttc ctcgagcgat gttacccgaa gacggcgtcc ctgaaaggcg     1140

agatatcagc atgaagctga agcttgaaga tcggcgtcac ttacgtactg ccttgagtca     1200

tagaccaact tacaagccat agaagtcggt gcagcttgtc ctgtccttta cacatgctct     1260

ataactatct aagtttggaa acattcacta cggtctacac agcaggatga c              1311


