                         SEQUENCE LISTING

<110>  RXi Pharmaceuticals Corporation
 
<120>  NUCLEIC ACID MOLECULES TARGETING SUPEROXIDE DISMUTASE 1 (SOD1)

<130>  R0659.70030WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/189,050
<151>  2015-07-06

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  1
gagaggcaug uua                                                          13


<210>  2
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  2
gagaggcaug uua                                                          13


<210>  3
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  3
gagaggcaug uua                                                          13


<210>  4
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  4
gagaggcaug uua                                                          13


<210>  5
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  5
gagaggcaug uua                                                          13


<210>  6
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  6
gagaggcaug uua                                                          13


<210>  7
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  7
gagaggcaug uua                                                          13


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  8
gagaggcaug uua                                                          13


<210>  9
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  9
gagaggcaug uua                                                          13


<210>  10
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  10
gagaggcaug uua                                                          13


<210>  11
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  11
agguggaaau gaa                                                          13


<210>  12
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  12
agguggaaau gaa                                                          13


<210>  13
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  13
agguggaaau gaa                                                          13


<210>  14
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  14
agguggaaau gaa                                                          13


<210>  15
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  15
agguggaaau gaa                                                          13


<210>  16
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  16
agguggaaau gaa                                                          13


<210>  17
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  17
agguggaaau gaa                                                          13


<210>  18
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  18
agguggaaau gaa                                                          13


<210>  19
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  19
agguggaaau gaa                                                          13


<210>  20
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  20
agguggaaau gaa                                                          13


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  21
agguggaaau gaa                                                          13


<210>  22
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  22
agguggaaau gaa                                                          13


<210>  23
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  23
agguggaaau gaa                                                          13


<210>  24
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  24
agguggaaau gaa                                                          13


<210>  25
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  25
agguggaaau gaa                                                          13


<210>  26
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  26
agguggaaau gaa                                                          13


<210>  27
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  27
agguggaaau gaa                                                          13


<210>  28
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  28
agguggaaau gaa                                                          13


<210>  29
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  29
agguggaaau gaa                                                          13


<210>  30
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  30
agguggaaau gaa                                                          13


<210>  31
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  31
gagaggcaug uua                                                          13


<210>  32
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  32
gagaggcaug uua                                                          13


<210>  33
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  33
gagaggcaug uua                                                          13


<210>  34
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  34
gagaggcaug uua                                                          13


<210>  35
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  35
gagaggcaug uua                                                          13


<210>  36
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  36
gagaggcaug uua                                                          13


<210>  37
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  37
gagaggcaug uua                                                          13


<210>  38
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  38
gagaggcaug uua                                                          13


<210>  39
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  39
gagaggcaug uua                                                          13


<210>  40
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  40
agguggaaau gaa                                                          13


<210>  41
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  41
agguggaaau gaa                                                          13


<210>  42
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  42
agguggaaau gaa                                                          13


<210>  43
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  43
agguggaaau gaa                                                          13


<210>  44
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  44
agguggaaau gaa                                                          13


<210>  45
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  45
agguggaaau gaa                                                          13


<210>  46
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  46
agguggaaau gaa                                                          13


<210>  47
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  47
agguggaaau gaa                                                          13


<210>  48
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  48
agguggaaau gaa                                                          13


<210>  49
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  49
agguggaaau gaa                                                          13


<210>  50
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  50
agguggaaau gaa                                                          13


<210>  51
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  51
agguggaaau gaa                                                          13


<210>  52
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  52
agguggaaau gaa                                                          13


<210>  53
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  53
agguggaaau gaa                                                          13


<210>  54
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  54
agguggaaau gaa                                                          13


<210>  55
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  55
agguggaaau gaa                                                          13


<210>  56
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  56
agguggaaau gaa                                                          13


<210>  57
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  57
agguggaaau gaa                                                          13


<210>  58
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  58
agguggaaau gaa                                                          13


<210>  59
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Phosphodiester linkage

<400>  59
agguggaaau gaa                                                          13


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  60
uaacaugccu cucuucaucc u                                                 21


<210>  61
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  61
uaacaugccu cucuucaucc u                                                 21


<210>  62
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  62
uaacaugccu cucuucauc                                                    19


<210>  63
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  63
uaacaugccu cucuucaucc u                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  64
uaacaugccu cucuucaucc u                                                 21


<210>  65
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  65
uaacaugccu cucuucaucc u                                                 21


<210>  66
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  66
uaacaugccu cucuucauc                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  67
uaacaugccu cucuucauc                                                    19


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  68
uaacaugccu cucuucaucc u                                                 21


<210>  69
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  69
uaacaugccu cucuucaucc u                                                 21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  70
uucauuucca ccuuugccca a                                                 21


<210>  71
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  71
uucauuucca ccuuugccca a                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  72
uucauuucca ccuuugccca a                                                 21


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  73
uucauuucca ccuuugccca a                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  74
uucauuucca ccuuugccca a                                                 21


<210>  75
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  75
uucauuucca ccuuugccca a                                                 21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  76
uucauuucca ccuuugccca a                                                 21


<210>  77
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  77
uucauuucca ccuuugccca a                                                 21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  78
uucauuucca ccuuugccca a                                                 21


<210>  79
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  79
uucauuucca ccuuugccca a                                                 21

<210>  80
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  80
uucauuucca ccuuugccca a                                                 21


<210>  81
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  81
uucauuucca ccuuugccca a                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  82
uucauuucca ccuuugccca a                                                 21


<210>  83
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  83
uucauuucca ccuuugccca a                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  84
uucauuucca ccuuugccca a                                                 21


<210>  85
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  85
uucauuucca ccuuugccca a                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  86
uucauuucca ccuuugccca a                                                 21


<210>  87
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  87
uucauuucca ccuuugccca a                                                 21



<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  88
uucauuucca ccuuugccca a                                                 21


<210>  89
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  89
uucauuucca ccuuugccca a                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  90
uaacaugccu cucuucaucc u                                                 21


<210>  91
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  91
uaacaugccu cucuucaucc u                                                 21


<210>  92
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  92
uaacaugccu cucuucauc                                                    19


<210>  93
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  93
uaacaugccu cucuucaucc u                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  94
uaacaugccu cucuucaucc u                                                 21


<210>  95
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  95
uaacaugccu cucuucauc                                                    19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Phosphodiester linkage

<400>  96
uaacaugccu cucuucauc                                                    19


<210>  97
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  97
uaacaugccu cucuucaucc u                                                 21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  98
uaacaugccu cucuucaucc u                                                 21


<210>  99
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  99
uucauuucca ccuuugccca a                                                 21


<210>  100
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  100
uucauuucca ccuuugccca a                                                 21


<210>  101
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  101
uucauuucca ccuuugccca a                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  102
uucauuucca ccuuugccca a                                                 21


<210>  103
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  103
uucauuucca ccuuugccca a                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  104
uucauuucca ccuuugccca a                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  105
uucauuucca ccuuugccca a                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  106
uucauuucca ccuuugccca a                                                 21


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  107
uucauuucca ccuuugccca a                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  108
uucauuucca ccuuugccca a                                                 21


<210>  109
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  109
uucauuucca ccuuugccca a                                                 21


<210>  110
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  110
uucauuucca ccuuugccca a                                                 21


<210>  111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  111
uucauuucca ccuuugccca a                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  112
uucauuucca ccuuugccca a                                                 21


<210>  113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  113
uucauuucca ccuuugccca a                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  114
uucauuucca ccuuugccca a                                                 21


<210>  115
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  115
uucauuucca ccuuugccca a                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  116
uucauuucca ccuuugccca a                                                 21



<210>  117
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  117
uucauuucca ccuuugccca a                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'Fluoro modified

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphodiester linkage

<400>  118
uucauuucca ccuuugccca a                                                 21


<210>  119
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  119
gtttggggcc agagtgggcg aggcgcggag gtctggccta taaagtagtc gcggagacgg       60

ggtgctggtt tgcgtcgtag tctcctgcag cgtctggggt ttccgttgca gtcctcggaa      120

ccaggacctc ggcgtggcct agcgagttat ggcgacgaag gccgtgtgcg tgctgaaggg      180

cgacggccca gtgcagggca tcatcaattt cgagcagaag gaaagtaatg gaccagtgaa      240

ggtgtgggga agcattaaag gactgactga aggcctgcat ggattccatg ttcatgagtt      300

tggagataat acagcaggct gtaccagtgc aggtcctcac tttaatcctc tatccagaaa      360

acacggtggg ccaaaggatg aagagaggca tgttggagac ttgggcaatg tgactgctga      420

caaagatggt gtggccgatg tgtctattga agattctgtg atctcactct caggagacca      480

ttgcatcatt ggccgcacac tggtggtcca tgaaaaagca gatgacttgg gcaaaggtgg      540

aaatgaagaa agtacaaaga caggaaacgc tggaagtcgt ttggcttgtg gtgtaattgg      600

gatcgcccaa taaacattcc cttggatgta gtctgaggcc ccttaactca tctgttatcc      660

tgctagctgt agaaatgtat cctgataaac attaaacact gtaatcttaa aagtgtaatt      720

gtgtgacttt ttcagagttg ctttaaagta cctgtagtga gaaactgatt tatgatcact      780

tggaagattt gtatagtttt ataaaactca gttaaaatgt ctgtttcaat gacctgtatt      840

ttgccagact taaatcacag atgggtatta aacttgtcag aatttctttg tcattcaagc      900

ctgtgaataa aaaccctgta tggcacttat tatgaggcta ttaaaagaat ccaaattcaa      960

actaaaaaaa aaaaaaaaaa a                                                981


<210>  120
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Phosphorothioate linkage

<400>  120
gagaggcaug uua                                                          13


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  121
uaacaugccu cucuucaucc u                                                 21


<210>  122
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Phosphorothioate linkage

<400>  122
gagaggcaug uua                                                          13


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  123
uaacaugccu cucuucaucc u                                                 21


<210>  124
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Phosphorothioate linkage

<400>  124
gagaggcaug uua                                                          13


<210>  125
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  Phosphorothioate linkage

<400>  125
uaacaugccu cucuucauc                                                    19


<210>  126
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'Ome modified

<400>  126
gagaggcaug uua                                                          13


<210>  127
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'Ome modified

<400>  127
gagaggcaug uua                                                          13


<210>  128
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  128
uaacaugccu cucuucaucc u                                                 21


<210>  129
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'Ome modified

<400>  129
gagaggcaug uua                                                          13


<210>  130
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (13)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  130
uaacaugccu cucuucaucc u                                                 21


<210>  131
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Phosphorothioate linkage

<400>  131
gagaggcaug uua                                                          13


<210>  132
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'fluoro modified

<400>  132
uaacaugccu cucuucauc                                                    19


<210>  133
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'Ome modified

<400>  133
gagaggcaug uua                                                          13


<210>  134
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'fluoro modified

<400>  134
uaacaugccu cucuucauc                                                    19


<210>  135
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Phosphodiester linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Phosphorothioate linkage

<400>  135
gagaggcaug uua                                                          13


<210>  136
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothiote linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  136
uaacaugccu cucuucaucc u                                                 21


<210>  137
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'Ome modified

<400>  137
gagaggcaug uua                                                          13


<210>  138
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'Ome modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  2'fluoro modified

<400>  138
uaacaugccu cucuucaucc u                                                 21


<210>  139
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  139
agguggaaau gaa                                                          13


<210>  140
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  140
agguggaaau gaa                                                          13


<210>  141
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  141
agguggaaau gaa                                                          13


<210>  142
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  142
agguggaaau gaa                                                          13


<210>  143
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  143
agguggaaau gaa                                                          13


<210>  144
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  144
agguggaaau gaa                                                          13


<210>  145
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  145
uucauuucca ccuuugccca a                                                 21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  146
uucauuucca ccuuugccca a                                                 21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  147
uucauuucca ccuuugccca a                                                 21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  148
uucauuucca ccuuugccca a                                                 21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  OCtyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  149
uucauuucca ccuuugccca a                                                 21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  150
uucauuucca ccuuugccca a                                                 21


<210>  151
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  151
agguggaaau gaa                                                          13


<210>  152
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  152
agguggaaau gaa                                                          13


<210>  153
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  153
agguggaaau gaa                                                          13


<210>  154
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  154
agguggaaau gaa                                                          13


<210>  155
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  155
agguggaaau gaa                                                          13


<210>  156
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  156
agguggaaau gaa                                                          13


<210>  157
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  OCtyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  157
uucauuucca ccuuugccca a                                                 21


<210>  158
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  OCtyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  158
uucauuucca ccuuugccca a                                                 21


<210>  159
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Octyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  159
uucauuucca ccuuugccca a                                                 21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  160
uucauuucca ccuuugccca a                                                 21


<210>  161
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  161
uucauuucca ccuuugccca a                                                 21


<210>  162
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  162
uucauuucca ccuuugccca a                                                 21


<210>  163
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  163
agguggaaau gaa                                                          13


<210>  164
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  164
agguggaaau gaa                                                          13


<210>  165
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  165
agguggaaau gaa                                                          13


<210>  166
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  166
agguggaaau gaa                                                          13


<210>  167
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  167
agguggaaau gaa                                                          13


<210>  168
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  168
agguggaaau gaa                                                          13


<210>  169
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  169
uucauuucca ccuuugccca a                                                 21


<210>  170
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  170
uucauuucca ccuuugccca a                                                 21


<210>  171
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  171
uucauuucca ccuuugccca a                                                 21


<210>  172
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Thiophene modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  172
uucauuucca ccuuugccca a                                                 21


<210>  173
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  173
uucauuucca ccuuugccca a                                                 21


<210>  174
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  174
uucauuucca ccuuugccca a                                                 21


<210>  175
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  175
agguggaaau gaa                                                          13


<210>  176
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  176
agguggaaau gaa                                                          13


<210>  177
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  177
agguggaaau gaa                                                          13


<210>  178
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  178
agguggaaau gaa                                                          13


<210>  179
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  179
agguggaaau gaa                                                          13


<210>  180
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  DY547 dye modified

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'OMe modified

<400>  180
agguggaaau gaa                                                          13


<210>  181
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  181
uucauuucca ccuuugccca a                                                 21

<210>  182
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  182
uucauuucca ccuuugccca a                                                 21


<210>  183
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  183
uucauuucca ccuuugccca a                                                 21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'fluoro modified

220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  184
uucauuucca ccuuugccca a                                                 21


<210>  185
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Deoxyribose modified

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Isobutyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  185
uucauuucca ccuuugccca a                                                 21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Phosphate modified

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'fluoro modified

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe modified

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'fluoro modified

<400>  186
uucauuucca ccuuugccca a                                                 21


