                         SEQUENCE LISTING

<110>  Inserm
 
<120>  ANTIBODIES HAVING SPECIFICITY TO MYOSIN 18A AND USES THEREOF

<130>  BIO15266 BENSUSSAN /MC

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  2054
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Asn Leu Met Lys Lys Asp Lys Asp Lys Asp Gly Gly Arg Lys 
1               5                   10                  15      


Glu Lys Lys Glu Lys Lys Glu Lys Lys Glu Arg Met Ser Ala Ala Glu 
            20                  25                  30          


Leu Arg Ser Leu Glu Glu Met Ser Leu Arg Arg Gly Phe Phe Asn Leu 
        35                  40                  45              


Asn Arg Ser Ser Lys Arg Glu Ser Lys Thr Arg Leu Glu Ile Ser Asn 
    50                  55                  60                  


Pro Ile Pro Ile Lys Val Ala Ser Gly Ser Asp Leu His Leu Thr Asp 
65                  70                  75                  80  


Ile Asp Ser Asp Ser Asn Arg Gly Ser Val Ile Leu Asp Ser Gly His 
                85                  90                  95      


Leu Ser Thr Ala Ser Ser Ser Asp Asp Leu Lys Gly Glu Glu Gly Ser 
            100                 105                 110         


Phe Arg Gly Ser Val Leu Gln Arg Ala Ala Lys Phe Gly Ser Leu Ala 
        115                 120                 125             


Lys Gln Asn Ser Gln Met Ile Val Lys Arg Phe Ser Phe Ser Gln Arg 
    130                 135                 140                 


Ser Arg Asp Glu Ser Ala Ser Glu Thr Ser Thr Pro Ser Glu His Ser 
145                 150                 155                 160 


Ala Ala Pro Ser Pro Gln Val Glu Val Arg Thr Leu Glu Gly Gln Leu 
                165                 170                 175     


Val Gln His Pro Gly Pro Gly Ile Pro Arg Pro Gly His Arg Ser Arg 
            180                 185                 190         


Ala Pro Glu Leu Val Thr Lys Lys Phe Pro Val Asp Leu Arg Leu Pro 
        195                 200                 205             


Pro Val Val Pro Leu Pro Pro Pro Thr Leu Arg Glu Leu Glu Leu Gln 
    210                 215                 220                 


Arg Arg Pro Thr Gly Asp Phe Gly Phe Ser Leu Arg Arg Thr Thr Met 
225                 230                 235                 240 


Leu Asp Arg Gly Pro Glu Gly Gln Ala Cys Arg Arg Val Val His Phe 
                245                 250                 255     


Ala Glu Pro Gly Ala Gly Thr Lys Asp Leu Ala Leu Gly Leu Val Pro 
            260                 265                 270         


Gly Asp Arg Leu Val Glu Ile Asn Gly His Asn Val Glu Ser Lys Ser 
        275                 280                 285             


Arg Asp Glu Ile Val Glu Met Ile Arg Gln Ser Gly Asp Ser Val Arg 
    290                 295                 300                 


Leu Lys Val Gln Pro Ile Pro Glu Leu Ser Glu Leu Ser Arg Ser Trp 
305                 310                 315                 320 


Leu Arg Ser Gly Glu Gly Pro Arg Arg Glu Pro Ser Asp Ala Lys Thr 
                325                 330                 335     


Glu Glu Gln Ile Ala Ala Glu Glu Ala Trp Asn Glu Thr Glu Lys Val 
            340                 345                 350         


Trp Leu Val His Arg Asp Gly Phe Ser Leu Ala Ser Gln Leu Lys Ser 
        355                 360                 365             


Glu Glu Leu Asn Leu Pro Glu Gly Lys Val Arg Val Lys Leu Asp His 
    370                 375                 380                 


Asp Gly Ala Ile Leu Asp Val Asp Glu Asp Asp Val Glu Lys Ala Asn 
385                 390                 395                 400 


Ala Pro Ser Cys Asp Arg Leu Glu Asp Leu Ala Ser Leu Val Tyr Leu 
                405                 410                 415     


Asn Glu Ser Ser Val Leu His Thr Leu Arg Gln Arg Tyr Gly Ala Ser 
            420                 425                 430         


Leu Leu His Thr Tyr Ala Gly Pro Ser Leu Leu Val Leu Gly Pro Arg 
        435                 440                 445             


Gly Ala Pro Ala Val Tyr Ser Glu Lys Val Met His Met Phe Lys Gly 
    450                 455                 460                 


Cys Arg Arg Glu Asp Met Ala Pro His Ile Tyr Ala Val Ala Gln Thr 
465                 470                 475                 480 


Ala Tyr Arg Ala Met Leu Met Ser Arg Gln Asp Gln Ser Ile Ile Leu 
                485                 490                 495     


Leu Gly Ser Ser Gly Ser Gly Lys Thr Thr Ser Cys Gln His Leu Val 
            500                 505                 510         


Gln Tyr Leu Ala Thr Ile Ala Gly Ile Ser Gly Asn Lys Val Phe Ser 
        515                 520                 525             


Val Glu Lys Trp Gln Ala Leu Tyr Thr Leu Leu Glu Ala Phe Gly Asn 
    530                 535                 540                 


Ser Pro Thr Ile Ile Asn Gly Asn Ala Thr Arg Phe Ser Gln Ile Leu 
545                 550                 555                 560 


Ser Leu Asp Phe Asp Gln Ala Gly Gln Val Ala Ser Ala Ser Ile Gln 
                565                 570                 575     


Thr Met Leu Leu Glu Lys Leu Arg Val Ala Arg Arg Pro Ala Ser Glu 
            580                 585                 590         


Ala Thr Phe Asn Val Phe Tyr Tyr Leu Leu Ala Cys Gly Asp Gly Thr 
        595                 600                 605             


Leu Arg Thr Glu Leu His Leu Asn His Leu Ala Glu Asn Asn Val Phe 
    610                 615                 620                 


Gly Ile Val Pro Leu Ala Lys Pro Glu Glu Lys Gln Lys Ala Ala Gln 
625                 630                 635                 640 


Gln Phe Ser Lys Leu Gln Ala Ala Met Lys Val Leu Gly Ile Ser Pro 
                645                 650                 655     


Asp Glu Gln Lys Ala Cys Trp Phe Ile Leu Ala Ala Ile Tyr His Leu 
            660                 665                 670         


Gly Ala Ala Gly Ala Thr Lys Glu Ala Ala Glu Ala Gly Arg Lys Gln 
        675                 680                 685             


Phe Ala Arg His Glu Trp Ala Gln Lys Ala Ala Tyr Leu Leu Gly Cys 
    690                 695                 700                 


Ser Leu Glu Glu Leu Ser Ser Ala Ile Phe Lys His Gln His Lys Gly 
705                 710                 715                 720 


Gly Thr Leu Gln Arg Ser Thr Ser Phe Arg Gln Gly Pro Glu Glu Ser 
                725                 730                 735     


Gly Leu Gly Asp Gly Thr Gly Pro Lys Leu Ser Ala Leu Glu Cys Leu 
            740                 745                 750         


Glu Gly Met Ala Ala Gly Leu Tyr Ser Glu Leu Phe Thr Leu Leu Val 
        755                 760                 765             


Ser Leu Val Asn Arg Ala Leu Lys Ser Ser Gln His Ser Leu Cys Ser 
    770                 775                 780                 


Met Met Ile Val Asp Thr Pro Gly Phe Gln Asn Pro Glu Gln Gly Gly 
785                 790                 795                 800 


Ser Ala Arg Gly Ala Ser Phe Glu Glu Leu Cys His Asn Tyr Thr Gln 
                805                 810                 815     


Asp Arg Leu Gln Arg Leu Phe His Glu Arg Thr Phe Val Gln Glu Leu 
            820                 825                 830         


Glu Arg Tyr Lys Glu Glu Asn Ile Glu Leu Ala Phe Asp Asp Leu Glu 
        835                 840                 845             


Pro Pro Thr Asp Asp Ser Val Ala Ala Val Asp Gln Ala Ser His Gln 
    850                 855                 860                 


Ser Leu Val Arg Ser Leu Ala Arg Thr Asp Glu Ala Arg Gly Leu Leu 
865                 870                 875                 880 


Trp Leu Leu Glu Glu Glu Ala Leu Val Pro Gly Ala Ser Glu Asp Thr 
                885                 890                 895     


Leu Leu Glu Arg Leu Phe Ser Tyr Tyr Gly Pro Gln Glu Gly Asp Lys 
            900                 905                 910         


Lys Gly Gln Ser Pro Leu Leu His Ser Ser Lys Pro His His Phe Leu 
        915                 920                 925             


Leu Gly His Ser His Gly Thr Asn Trp Val Glu Tyr Asn Val Thr Gly 
    930                 935                 940                 


Trp Leu Asn Tyr Thr Lys Gln Asn Pro Ala Thr Gln Asn Ala Pro Arg 
945                 950                 955                 960 


Leu Leu Gln Asp Ser Gln Lys Lys Ile Ile Ser Asn Leu Phe Leu Gly 
                965                 970                 975     


Arg Ala Gly Ser Ala Thr Val Leu Ser Gly Ser Ile Ala Gly Leu Glu 
            980                 985                 990         


Gly Gly Ser Gln Leu Ala Leu Arg  Arg Ala Thr Ser Met  Arg Lys Thr 
        995                 1000                 1005             


Phe Thr  Thr Gly Met Ala Ala  Val Lys Lys Lys Ser  Leu Cys Ile 
    1010                 1015                 1020             


Gln Met  Lys Leu Gln Val Asp  Ala Leu Ile Asp Thr  Ile Lys Lys 
    1025                 1030                 1035             


Ser Lys  Leu His Phe Val His  Cys Phe Leu Pro Val  Ala Glu Gly 
    1040                 1045                 1050             


Trp Ala  Gly Glu Pro Arg Ser  Ala Ser Ser Arg Arg  Val Ser Ser 
    1055                 1060                 1065             


Ser Ser  Glu Leu Asp Leu Pro  Ser Gly Asp His Cys  Glu Ala Gly 
    1070                 1075                 1080             


Leu Leu  Gln Leu Asp Val Pro  Leu Leu Arg Thr Gln  Leu Arg Gly 
    1085                 1090                 1095             


Ser Arg  Leu Leu Asp Ala Met  Arg Met Tyr Arg Gln  Gly Tyr Pro 
    1100                 1105                 1110             


Asp His  Met Val Phe Ser Glu  Phe Arg Arg Arg Phe  Asp Val Leu 
    1115                 1120                 1125             


Ala Pro  His Leu Thr Lys Lys  His Gly Arg Asn Tyr  Ile Val Val 
    1130                 1135                 1140             


Asp Glu  Arg Arg Ala Val Glu  Glu Leu Leu Glu Cys  Leu Asp Leu 
    1145                 1150                 1155             


Glu Lys  Ser Ser Cys Cys Met  Gly Leu Ser Arg Val  Phe Phe Arg 
    1160                 1165                 1170             


Ala Gly  Thr Leu Ala Arg Leu  Glu Glu Gln Arg Asp  Glu Gln Thr 
    1175                 1180                 1185             


Ser Arg  Asn Leu Thr Leu Phe  Gln Ala Ala Cys Arg  Gly Tyr Leu 
    1190                 1195                 1200             


Ala Arg  Gln His Phe Lys Lys  Arg Lys Ile Gln Asp  Leu Ala Ile 
    1205                 1210                 1215             


Arg Cys  Val Gln Lys Asn Ile  Lys Lys Asn Lys Gly  Val Lys Asp 
    1220                 1225                 1230             


Trp Pro  Trp Trp Lys Leu Phe  Thr Thr Val Arg Pro  Leu Ile Glu 
    1235                 1240                 1245             


Val Gln  Leu Ser Glu Glu Gln  Ile Arg Asn Lys Asp  Glu Glu Ile 
    1250                 1255                 1260             


Gln Gln  Leu Arg Ser Lys Leu  Glu Lys Ala Glu Lys  Glu Arg Asn 
    1265                 1270                 1275             


Glu Leu  Arg Leu Asn Ser Asp  Arg Leu Glu Ser Arg  Ile Ser Glu 
    1280                 1285                 1290             


Leu Thr  Ser Glu Leu Thr Asp  Glu Arg Asn Thr Gly  Glu Ser Ala 
    1295                 1300                 1305             


Ser Gln  Leu Leu Asp Ala Glu  Thr Ala Glu Arg Leu  Arg Ala Glu 
    1310                 1315                 1320             


Lys Glu  Met Lys Glu Leu Gln  Thr Gln Tyr Asp Ala  Leu Lys Lys 
    1325                 1330                 1335             


Gln Met  Glu Val Met Glu Met  Glu Val Met Glu Ala  Arg Leu Ile 
    1340                 1345                 1350             


Arg Ala  Ala Glu Ile Asn Gly  Glu Val Asp Asp Asp  Asp Ala Gly 
    1355                 1360                 1365             


Gly Glu  Trp Arg Leu Lys Tyr  Glu Arg Ala Val Arg  Glu Val Asp 
    1370                 1375                 1380             


Phe Thr  Lys Lys Arg Leu Gln  Gln Glu Phe Glu Asp  Lys Leu Glu 
    1385                 1390                 1395             


Val Glu  Gln Gln Asn Lys Arg  Gln Leu Glu Arg Arg  Leu Gly Asp 
    1400                 1405                 1410             


Leu Gln  Ala Asp Ser Glu Glu  Ser Gln Arg Ala Leu  Gln Gln Leu 
    1415                 1420                 1425             


Lys Lys  Lys Cys Gln Arg Leu  Thr Ala Glu Leu Gln  Asp Thr Lys 
    1430                 1435                 1440             


Leu His  Leu Glu Gly Gln Gln  Val Arg Asn His Glu  Leu Glu Lys 
    1445                 1450                 1455             


Lys Gln  Arg Arg Phe Asp Ser  Glu Leu Ser Gln Ala  His Glu Glu 
    1460                 1465                 1470             


Ala Gln  Arg Glu Lys Leu Gln  Arg Glu Lys Leu Gln  Arg Glu Lys 
    1475                 1480                 1485             


Asp Met  Leu Leu Ala Glu Ala  Phe Ser Leu Lys Gln  Gln Leu Glu 
    1490                 1495                 1500             


Glu Lys  Asp Met Asp Ile Ala  Gly Phe Thr Gln Lys  Val Val Ser 
    1505                 1510                 1515             


Leu Glu  Ala Glu Leu Gln Asp  Ile Ser Ser Gln Glu  Ser Lys Asp 
    1520                 1525                 1530             


Glu Ala  Ser Leu Ala Lys Val  Lys Lys Gln Leu Arg  Asp Leu Glu 
    1535                 1540                 1545             


Ala Lys  Val Lys Asp Gln Glu  Glu Glu Leu Asp Glu  Gln Ala Gly 
    1550                 1555                 1560             


Thr Ile  Gln Met Leu Glu Gln  Ala Lys Leu Arg Leu  Glu Met Glu 
    1565                 1570                 1575             


Met Glu  Arg Met Arg Gln Thr  His Ser Lys Glu Met  Glu Ser Arg 
    1580                 1585                 1590             


Asp Glu  Glu Val Glu Glu Ala  Arg Gln Ser Cys Gln  Lys Lys Leu 
    1595                 1600                 1605             


Lys Gln  Met Glu Val Gln Leu  Glu Glu Glu Tyr Glu  Asp Lys Gln 
    1610                 1615                 1620             


Lys Val  Leu Arg Glu Lys Arg  Glu Leu Glu Gly Lys  Leu Ala Thr 
    1625                 1630                 1635             


Leu Ser  Asp Gln Val Asn Arg  Arg Asp Phe Glu Ser  Glu Lys Arg 
    1640                 1645                 1650             


Leu Arg  Lys Asp Leu Lys Arg  Thr Lys Ala Leu Leu  Ala Asp Ala 
    1655                 1660                 1665             


Gln Leu  Met Leu Asp His Leu  Lys Asn Ser Ala Pro  Ser Lys Arg 
    1670                 1675                 1680             


Glu Ile  Ala Gln Leu Lys Asn  Gln Leu Glu Glu Ser  Glu Phe Thr 
    1685                 1690                 1695             


Cys Ala  Ala Ala Val Lys Ala  Arg Lys Ala Met Glu  Val Glu Ile 
    1700                 1705                 1710             


Glu Asp  Leu His Leu Gln Ile  Asp Asp Ile Ala Lys  Ala Lys Thr 
    1715                 1720                 1725             


Ala Leu  Glu Glu Gln Leu Ser  Arg Leu Gln Arg Glu  Lys Asn Glu 
    1730                 1735                 1740             


Ile Gln  Asn Arg Leu Glu Glu  Asp Gln Glu Asp Met  Asn Glu Leu 
    1745                 1750                 1755             


Met Lys  Lys His Lys Ala Ala  Val Ala Gln Ala Ser  Arg Asp Leu 
    1760                 1765                 1770             


Ala Gln  Ile Asn Asp Leu Gln  Ala Gln Leu Glu Glu  Ala Asn Lys 
    1775                 1780                 1785             


Glu Lys  Gln Glu Leu Gln Glu  Lys Leu Gln Ala Leu  Gln Ser Gln 
    1790                 1795                 1800             


Val Glu  Phe Leu Glu Gln Ser  Met Val Asp Lys Ser  Leu Val Ser 
    1805                 1810                 1815             


Arg Gln  Glu Ala Lys Ile Arg  Glu Leu Glu Thr Arg  Leu Glu Phe 
    1820                 1825                 1830             


Glu Arg  Thr Gln Val Lys Arg  Leu Glu Ser Leu Ala  Ser Arg Leu 
    1835                 1840                 1845             


Lys Glu  Asn Met Glu Lys Leu  Thr Glu Glu Arg Asp  Gln Arg Ile 
    1850                 1855                 1860             


Ala Ala  Glu Asn Arg Glu Lys  Glu Gln Asn Lys Arg  Leu Gln Arg 
    1865                 1870                 1875             


Gln Leu  Arg Asp Thr Lys Glu  Glu Met Gly Glu Leu  Ala Arg Lys 
    1880                 1885                 1890             


Glu Ala  Glu Ala Ser Arg Lys  Lys His Glu Leu Glu  Met Asp Leu 
    1895                 1900                 1905             


Glu Ser  Leu Glu Ala Ala Asn  Gln Ser Leu Gln Ala  Asp Leu Lys 
    1910                 1915                 1920             


Leu Ala  Phe Lys Arg Ile Gly  Asp Leu Gln Ala Ala  Ile Glu Asp 
    1925                 1930                 1935             


Glu Met  Glu Ser Asp Glu Asn  Glu Asp Leu Ile Asn  Ser Leu Gln 
    1940                 1945                 1950             


Asp Met  Val Thr Lys Tyr Gln  Lys Arg Lys Asn Lys  Leu Glu Gly 
    1955                 1960                 1965             


Asp Ser  Asp Val Asp Ser Glu  Leu Glu Asp Arg Val  Asp Gly Val 
    1970                 1975                 1980             


Lys Ser  Trp Leu Ser Lys Asn  Lys Gly Pro Ser Lys  Ala Ala Ser 
    1985                 1990                 1995             


Asp Asp  Gly Ser Leu Lys Ser  Ser Ser Pro Thr Ser  Tyr Trp Lys 
    2000                 2005                 2010             


Ser Leu  Ala Pro Asp Arg Ser  Asp Asp Glu His Asp  Pro Leu Asp 
    2015                 2020                 2025             


Asn Thr  Ser Arg Pro Arg Tyr  Ser His Ser Tyr Leu  Ser Asp Ser 
    2030                 2035                 2040             


Asp Thr  Glu Ala Lys Leu Thr  Glu Thr Asn Ala 
    2045                 2050                 


