                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Fusion molecules

<130>  DE2015/080WOPCT

<150>  EP 15 306 106.4
<151>  July 7, 2015

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGAL wt

<400>  1

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  2
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.12C05

<400>  2

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Asn Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ile Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Val Val Gln Phe Trp Asp Lys Lys Cys Leu Tyr Gln Ile 
65                  70                  75                  80  


Gln Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly His 
                85                  90                  95      


Ile Lys Ser Lys Pro Gly His Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Arg Val Trp Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Asp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  3
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.02P05

<400>  3

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Thr Ala Gly Asn Gly Phe Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Leu Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Trp Phe Ala Leu Lys Lys Cys Tyr Tyr Asp Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ile 
                85                  90                  95      


Ile Lys Ser Glu Pro Gly His Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asn Gln 
        115                 120                 125             


Asn Arg Glu Asn Phe Gln Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  4
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.09A08

<400>  4

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Ser Glu Lys Lys Cys Ser Tyr Ser Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Lys Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Ala Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  5
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.09M05

<400>  5

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Asn Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Thr Phe Glu Ala Lys Lys Cys Arg Tyr Arg Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Tyr 
                85                  90                  95      


Ile Lys Ser Lys Pro Gly Pro Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Gly Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  6
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.09E05

<400>  6

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Val Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Val Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  7
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.09E13

<400>  7

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Phe Phe Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ala Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Trp Phe Leu Asn Lys Lys Cys Gln Tyr Glu Ile 
65                  70                  75                  80  


His Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Tyr 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Tyr Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Val Val His Gln 
        115                 120                 125             


Asn Arg Asp Lys Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  8
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.17L07

<400>  8

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Pro Glu Lys Lys Cys Ile Tyr Ser Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  9
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.17O10

<400>  9

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Pro Asp Lys Lys Cys Ile Tyr Ser Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Asp Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Val Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  10
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.19M08

<400>  10

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Pro Glu Lys Lys Cys Thr Tyr Ser Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Glu Thr Ser His Leu Val Arg Val Met Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Asp Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  11
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.17O03

<400>  11

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Pro Asp Lys Lys Cys Val Tyr Ser Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Asn Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Val Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  12
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0510.05H10

<400>  12

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Leu Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Val Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  13
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.06H10

<400>  13

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  14
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.04N16

<400>  14

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro 
        35                  40                  45              


Leu Lys Met Met Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Val Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  15
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0544.01B06_H28Q_N65D

<400>  15

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asp Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  16
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0544.04C04_H28Q_N65D

<400>  16

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Thr Ala Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Pro Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  17
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.04N16_N65D

<400>  17

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro 
        35                  40                  45              


Leu Lys Met Met Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Val Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  18
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.04N16_N65Q

<400>  18

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro 
        35                  40                  45              


Leu Lys Met Met Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Val Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  19
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S447.3 M1.1_N4

<400>  19

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Glu Val Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Ser Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Gln Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  20
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S449.1 M1.1_M5

<400>  20

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Arg Phe Ile Met Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ile 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Met Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  21
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S449.5 M1.1_L10

<400>  21

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Ile Ala Gly Asn Thr Val Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Ala Pro Lys Lys Cys Ile Tyr Ser Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Met 
                85                  90                  95      


Ile Lys Ser Ser Pro Gly Gly Thr Ser Ala Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  22
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S449.8 M1.1_F3

<400>  22

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Asn Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ala Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Ser Gln Lys Lys Cys Met Tyr Ala Ile 
65                  70                  75                  80  


Tyr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Arg 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Thr Thr Ser Ile Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Met Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  23
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S449.5 M1.1_E8

<400>  23

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn His Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ala Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Gly Arg Lys Lys Cys His Tyr Trp Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Arg 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ala Val Asp Gln 
        115                 120                 125             


Asn Arg Glu Asn Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  24
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S437.1 M1.1_P2

<400>  24

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Asn Ala Gly Asn Gly Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Arg Val Trp Phe Asn Gln Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Thr Pro Gly Trp Thr Ser Asn Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Asn Val Met Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  25
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S449.1 M1.1_I7

<400>  25

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Gly Arg Lys Lys Cys Gly Tyr Trp Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Trp Pro Gly Ile Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Asn Gln 
        115                 120                 125             


Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  26
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.06L06

<400>  26

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Glu Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Ser Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Val Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Asn Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  27
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.08G23

<400>  27

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Ser Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Gln Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  28
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.06G17

<400>  28

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe His Lys Lys Lys Cys Asn Tyr Phe Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gln Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  29
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.03N20

<400>  29

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Gln Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Trp Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly His Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  30
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.05F20

<400>  30

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Arg Phe Ile Phe Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Met Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  31
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22

<400>  31

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  32
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.06L06_N65D_S79F

<400>  32

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Glu Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Phe Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Val Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Asn Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  33
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.06L06_N65Q_S79F

<400>  33

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Glu Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Phe Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Val Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Asn Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  34
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65D

<400>  34

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  35
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65Q

<400>  35

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  36
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_H28Q_T54A_N65D

<400>  36

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  37
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_N65Q

<400>  37

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  38
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.14D07

<400>  38

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Trp Met Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


His Lys Met Asn Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Lys Phe Gln Ala Lys Lys Cys Ile Tyr Ser Ile 
65                  70                  75                  80  


His Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ile 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Gly Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val His Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Gln Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  39
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.05N20

<400>  39

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Arg Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ile Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gln Val Asn Phe Trp Leu Lys Lys Cys Ala Tyr Ser Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Arg 
                85                  90                  95      


Ile Lys Ser Ile Pro Gly Pro Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Thr Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  40
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.16B14

<400>  40

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Arg Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Arg Phe Leu Tyr Lys Lys Cys Ile Tyr Ser Ile 
65                  70                  75                  80  


Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Phe Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Ala Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  41
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.15E20

<400>  41

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Trp Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asn Val Arg Phe Trp Pro Lys Lys Cys Arg Tyr Ser Ile 
65                  70                  75                  80  


Ser Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Met 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Gly Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  42
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0466.13C10

<400>  42

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr Asp Ile 
65                  70                  75                  80  


Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  43
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0510.11H24

<400>  43

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  44
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.01M12_x103Q

<400>  44

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Thr Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg Arg Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Val 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  45
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0512.01F10_x103Q

<400>  45

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  46
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0510.10A04_x103Q

<400>  46

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg Tyr Lys Lys Cys Gln Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Ser Glu 
                85                  90                  95      


Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
            100                 105                 110         


Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Phe 
        115                 120                 125             


Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
    130                 135                 140                 


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
145                 150                 155                 160 


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                165                 170                 


<210>  47
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07G09

<400>  47

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Arg Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  48
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07K20

<400>  48

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asn Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Pro Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  49
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07K21

<400>  49

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Gly Arg Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  50
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07G09_N65D

<400>  50

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Arg Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  51
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07K20_N65D

<400>  51

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asn Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Pro Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  52
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07K21_N65D

<400>  52

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Gly Arg Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  53
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0530.07G09_H28Q_N65D

<400>  53

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ala Arg Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  54
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0455.04F12

<400>  54

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ile Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


His Lys Met Leu Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr His Val Thr Phe Lys Trp Lys Lys Cys Tyr Tyr Ala Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Met 
                85                  90                  95      


Ile Lys Ser Glu Pro Gly His Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asp Gln 
        115                 120                 125             


Asn Arg Glu Glu Phe Leu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  55
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0455.04F23

<400>  55

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys His Tyr Arg Ile 
65                  70                  75                  80  


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  56
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0455.04F09

<400>  56

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  57
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0455.04M08

<400>  57

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ala Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Arg Phe Trp Arg Lys Lys Cys Arg Tyr Asp Ile 
65                  70                  75                  80  


Trp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Pro 
                85                  90                  95      


Ile Lys Ser Glu Pro Gly Gln Thr Ser Arg Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Leu Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  58
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0522.15K24

<400>  58

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Leu Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys Gly Val Trp Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Ala Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  59
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0527.05N11

<400>  59

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Thr 
65                  70                  75                  80  


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys Gly Val Trp Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  60
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0522.05A05

<400>  60

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Gly Arg Asp Pro 
        35                  40                  45              


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys Leu Tyr Arg Ile 
65                  70                  75                  80  


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  61
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0522.05M06

<400>  61

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly Asp Tyr Asp Pro 
        35                  40                  45              


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys His Tyr Arg Ile 
65                  70                  75                  80  


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  62
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0522.05A05_H28Q_N65D

<400>  62

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Gly Arg Asp Pro 
        35                  40                  45              


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys Leu Tyr Arg Ile 
65                  70                  75                  80  


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  63
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0522.05M06_N65D

<400>  63

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly Asp Tyr Asp Pro 
        35                  40                  45              


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys His Tyr Arg Ile 
65                  70                  75                  80  


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  64
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3004wt = NGAL98

<400>  64

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  65
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.12C05

<400>  65
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcaatgc cggaaatgga      120

tggctgcgtg aggataagga tccgatcaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgttgtgcaa ttttgggaca agaaatgcct gtaccaaatt      240

caaacctttg tgccggggag ccagccgggc gagtttactt taggccacat taaaagtaaa      300

ccgggccaca catcacactt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agcgtgtgtg gcagaaccgc gagtggtttg acatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  66
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.02P05

<400>  66
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcaccgc cggaaatgga      120

ttcctgcgtg aggataagga tccgctgaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cagcgtgtgg tttgcactga agaaatgcta ctacgacatt      240

ggaacctttg tgccggggag ccagccgggc gagtttactt taggcatcat taaaagtgag      300

ccgggccaca catcacaatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtgggtgaa tcagaaccgc gagaattttc aaatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  67
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.09A08

<400>  67
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatacc      120

accctgcgtg aggataagga tccgcctaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtgcaa tttagcgaga agaaatgcag ctacagcatt      240

atcacctttg tgccggggag ccagccgggc gagtttactt taggcggaat taaaagtaat      300

ccgggcaaaa catcacactt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtacgtggc acagaaccgc gagggattta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  68
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.09M05

<400>  68
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcttcgc cggaaataat      120

cgtctgcgtg aggataagga tccgcctaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtgacc tttgaggcaa agaaatgccg ttaccgtatt      240

atcacctttg tgccggggag ccagccgggc gagtttactt taggctacat taaaagtaaa      300

ccgggcccta catcattctt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agagcgtgac ccagaaccgc gagtggtttg gaatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  69
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.09E05

<400>  69
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcctggc cggaaatgga      120

tggctgcgtg aggataagga tccggttaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgttgtggac tttgagctga agaaatgccg ttacatgatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcgacat taaaagtttc      300

ccgggctgga catcacaatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggagtgta ccagaaccgc gagtggtttc acatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  70
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.09E13

<400>  70
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatttc      120

ttcctgcgtg aggataagga tccggcaaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgtgg tttctgaata agaaatgcca atacgagatt      240

cacacctttg tgccggggag ccagccgggc gagtttactt taggctacat taaaagttac      300

ccgggctaca catcacactt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca aggttgtgca ccagaaccgc gataaatttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  71
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.17L07

<400>  71
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatacg      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgcag tttcctgaga agaaatgcat ttactctact      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtagt      300

ccgggccaga catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgat tcagaaccgc gaggggttta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  72
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.17O10

<400>  72
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatacg      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgcag tttccggata agaaatgcat ttactcgatt      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcgggat taaaagtaat      300

ccgggcgata catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtggt gcagaaccgc gagggtttta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  73
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.19M08

<400>  73
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatacg      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgcag tttcctgaga agaaatgcac gtactcgatt      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcgatat taaaagtaat      300

ccgggcgaga catcacattt ggtccgcgtc atgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgga tcagaaccgc gaggggttta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  74
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.17O03

<400>  74
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatact      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgcag tttccggata agaaatgcgt gtactcgatt      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcgggat taaaagtaat      300

ccgggcaata catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtggt gcagaaccgc gaggggttta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  75
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0510.05H10

<400>  75
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccttgc cggaaatggt      120

tggctgcgtg aggataagga tccgcttaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgtggtggat tttgagctta agaaatgcag gtacatgatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcgatat taaaagttct      300

ccgggctgga catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggggtgta tcagaaccgc gagtggtttc atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  76
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.06H10

<400>  76
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggctgggc cggaaatacg      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcgg tcatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgcag tttcccgaga aggaatgcat ttactctact      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtagt      300

ccgggccaga catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgac tcagaaccgc gaggggttta atatcacgct gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  77
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.04N16

<400>  77
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccttgc cggaaatggt      120

tggctgcgtg aggatgagga tccgcttaaa atgatggcgg ccgtttacga gttgagagaa      180

gataaatcat ataacgtcac cgtggtggat tttgagcttg aggaatgcag gtacatgact      240

gagacctttg tgccggggaa ccagccgggc gagtttactt taggcgatat taaaagttct      300

ccgggctgga catcacagct ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggggtgta tcagaaccgc gagtggtttc atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  78
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0544.01B06_H28Q_N65D

<400>  78
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaagggaaa tggtatgtcg tgggctgggc cggagatacg      120

acgctgcgtg aggataagga tccgcctaaa atgcctgcgg tcatttacga gttgaaagaa      180

gataaatcat atgatgtcac cgatgtgcag tttcccgaga aggaatgcat ttactctact      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtagt      300

ccgggccaga catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgac tcagaaccgc gaggggttta atatcgcgct gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  79
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0544.04C04_H28Q_N65D

<400>  79
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaagggaaa tggtatgtcg tgggctgggc cggaaatacg      120

gctctgcgtg aggataagga tccgcctaaa atgcctgcgg tcatttacga gttgaaagaa      180

gataaatcat atgatgtcac cgatgtgcag tttcccgaga aggaatgcat ttactctact      240

attacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtagt      300

ccgggccaga catcacattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgac tcagaaccgc gaggggttta atatcgctct gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  80
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.04N16_N65D

<400>  80
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccttgc cggaaatggt      120

tggctgcgtg aggatgagga tccgcttaaa atgatggcgg ccgtttacga gttgagagaa      180

gataaatcat atgacgtcac cgtggtggat tttgagcttg aggaatgcag gtacatgact      240

gagacctttg tgccggggaa ccagccgggc gagtttactt taggcgatat taaaagttct      300

ccgggctgga catcacagct ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggggtgta tcagaaccgc gagtggtttc atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  81
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.04N16_N65Q

<400>  81
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccttgc cggaaatggt      120

tggctgcgtg aggatgagga tccgcttaaa atgatggcgg ccgtttacga gttgagagaa      180

gataaatcat atcaggtcac cgtggtggat tttgagcttg aggaatgcag gtacatgact      240

gagacctttg tgccggggaa ccagccgggc gagtttactt taggcgatat taaaagttct      300

ccgggctgga catcacagct ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggggtgta tcagaaccgc gagtggtttc atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  82
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S447.3 M1.1_N4

<400>  82
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatgag      120

gttctgcgtg aggataagga tccgggaaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttcacaata agaaatgcaa ttacagcatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtaat      300

ccgggccaaa catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaagtgaa acagaaccgc gagggatttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  83
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S449.1 M1.1_M5

<400>  83
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcctggc cggaaatacc      120

atcctgcgtg aggataagga tccgggaaaa atgaatgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtgcgt tttatcatga agaaatgcca ctactacatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcatcat taaaagtaat      300

ccgggcacca catcacaatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agatcgtgcg tcagaaccgc gagatgtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  84
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S449.5 M1.1_L10

<400>  84
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcatcgc cggaaatacc      120

gttctgcgtg aggataagga tccgggaaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttgcaccta agaaatgcat ctacagcatt      240

agcacctttg tgccggggag ccagccgggc gagtttactt taggcatgat taaaagtagc      300

ccgggcggaa catcagcatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaagtgag ccagaaccgc gaggtttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  85
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S449.8 M1.1_F3

<400>  85
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcctggc cggaaataat      120

atcctgcgtg aggataagga tccggcaaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttagccaaa agaaatgcat gtacgcaatt      240

tacacctttg tgccggggag ccagccgggc gagtttactt taggccgtat taaaagtcct      300

ccgggcacca catcaatctt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaagtgat gcagaaccgc gagttctttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  86
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S449.5 M1.1_E8

<400>  86
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcctggc cggaaatcac      120

atcctgcgtg aggataagga tccggcaaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttggacgta agaaatgcca ctactggatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggccgtat taaaagtgac      300

ccgggcatga catcattctt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca aggcagtgga ccagaaccgc gagaattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  87
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S437.1 M1.1_P2

<400>  87
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcaatgc cggaaatgga      120

cgtctgcgtg aggataagga tccgcctaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccgtgtgtgg tttaatcaaa agaaatgcaa atacgacatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcgacat taaaagtacc      300

ccgggctgga catcaaattt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaatgtgat gcagaaccgc gagatctttt acatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  88
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S449.1 M1.1_I7

<400>  88
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatacc      120

accctgcgtg aggataagga tccgggaaaa atgggagcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttggacgta agaaatgcgg atactggatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcgcaat taaaagttgg      300

ccgggcatca catcaggatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaagtgaa tcagaaccgc gaggtttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  89
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.06L06

<400>  89
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatgag      120

gtgctgcgtg atgataagga tccggggaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttcataata agaaatgcaa ttactcgatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaagat taaaagtaat      300

ccgggcgtga catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaatgtgaa gcagaaccgc gaggggtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  90
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.08G23

<400>  90
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatact      120

gtgctgcgtg atgataagga tccggggaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttcataata agaaatgcaa ttactctatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggccaga catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtgaa gcagaaccgc gaggtgtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  91
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.06G17

<400>  91
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatacg      120

gtgctgcgtg acgataagga tccgggtaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgg tttcataaga agaaatgcaa ttactttatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaagat taaaagtcat      300

ccgggccaga catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtgaa gcagaaccgc gaggcgtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  92
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.03N20

<400>  92
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatcag      120

gtgctgcgtg atgataagga tccgggtaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttcataata agaaatgcaa ttactggatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtaat      300

ccgggccata catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtgaa gcagaaccgc gagggttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  93
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.05F20

<400>  93
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaatacg      120

attctgcgtg aggataagga tccggggaaa atgaatgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgagg tttattttta agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcatga catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  94
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.01H22

<400>  94
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatact      120

attctgcgtg aggataagga tccggggaaa atgaatgcaa ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgatgtgagg tttattagga agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcacta catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  95
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.06L06_N65D_S79F

<400>  95
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatgag      120

gtgctgcgtg atgataagga tccggggaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat atgatgtcac cgaggtgagg tttcataata agaaatgcaa ttacttcatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaagat taaaagtaat      300

ccgggcgtga catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaatgtgaa gcagaaccgc gaggggtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  96
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0475.06L06_N65Q_S79F

<400>  96
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatgag      120

gtgctgcgtg atgataagga tccggggaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat atcaggtcac cgaggtgagg tttcataata agaaatgcaa ttacttcatt      240

gagacctttg tgccggggag ccagccgggc gagtttactt taggcaagat taaaagtaat      300

ccgggcgtga catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaatgtgaa gcagaaccgc gaggggtttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  97
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65D

<400>  97
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatact      120

attctgcgtg aggataagga tccggggaaa atgaatgcag ccatttacga gttgaaagaa      180

gataaatcat atgatgtcac cgatgtgagg tttattagga agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcacta catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  98
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65Q

<400>  98
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatact      120

attctgcgtg aggataagga tccggggaaa atgaatgcag ccatttacga gttgaaagaa      180

gataaatcat atcaggtcac cgatgtgagg tttattagga agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcacta catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  99
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_H28Q_T54A_N65D

<400>  99
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaagggaaa tggtatgtcg tgggcgtggc cggaaatact      120

attctgcgtg aggataagga tccggggaaa atgaatgcag ccatttacga gttgaaagaa      180

gataaatcat atgatgtcac cgatgtgagg tttattagga agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcacta catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  100
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_N65Q

<400>  100
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgtggc cggaaatact      120

attctgcgtg aggataagga tccggggaaa atgaatgcaa ccatttacga gttgaaagaa      180

gataaatcat atcaggtcac cgatgtgagg tttattagga agaaatgcca ttactatatt      240

gatacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagttat      300

ccgggcacta catcacagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agattgtgag gcagaaccgc gagatttttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  101
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.14D07

<400>  101
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcttcgc cggaaattgg      120

atgctgcgtg aggataagga tccgcacaaa atgaatgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgaaa tttcaagcaa agaaatgcat ctacagcatt      240

cacacctttg tgccggggag ccagccgggc gagtttactt taggcatcat taaaagtaat      300

ccgggcggaa catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtgggtgca ccagaaccgc gagttctttc aaatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  102
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.05N20

<400>  102
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcttcgc cggaaatcgt      120

tggctgcgtg aggataagga tccgatcaaa atgtacgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccaagtgaat ttttggctga agaaatgcgc atacagcatt      240

agcacctttg tgccggggag ccagccgggc gagtttactt taggccgtat taaaagtatc      300

ccgggcccta catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaccgtgat ccagaaccgc gagttctttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  103
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.16B14

<400>  103
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcttcgc cggaaatctg      120

ctgctgcgtg aggataagga tccgcgtaaa atgcgtgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtgcgt tttctgtaca agaaatgcat ctacagcatt      240

gcaacctttg tgccggggag ccagccgggc gagtttactt taggcggaat taaaagtgca      300

ccgggcttca catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtgggtggc acagaaccgc gagtactttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  104
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.15E20

<400>  104
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcttcgc cggaaattgg      120

cgtctgcgtg aggataagga tccgcctaaa atgagcgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac caatgtgcgt ttttggccta agaaatgccg ttacagcatt      240

agcacctttg tgccggggag ccagccgggc gagtttactt taggcatgat taaaagtcct      300

ccgggcggaa catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtgggtgtt ccagaaccgc gagttctttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  105
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0466.13C10

<400>  105
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctg      120

gcactgcgtg aggataagga tccgaaaaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgcgt tttcgtcaca agaaatgcca atacgacatt      240

gcaacctttg tgccggggag ccagccgggc gagtttactt taggcctgat taaaagtgac      300

ccgggccaaa catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaagtggt tcagaaccgc gagttctttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  106
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0510.11H24

<400>  106
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcaga agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  107
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.01M12_X103Q

<400>  107
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

actctgcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcgta agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggcgtgat taaaagtgat      300

ccgggccaga catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  108
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0512.01F10_X103Q

<400>  108
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga catcagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  109
<211>  522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0510.10A04_X103Q

<400>  109
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg aggataagga tccgaagaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttcggtata agaaatgcca gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taagtgagcc gggccagaca      300

tcagagttgg tccgcgtcgt gagcaccaac tacaaccagc atgccatggt gttcttcaag      360

aaggtggtgc agaaccgcga gtttttttgg atcacactgt acgggcgcac gaaagaactg      420

acaagcgagc tgaaggaaaa ttttatccgc ttttccaaat ctctgggcct ccctgaaaac      480

cacatcgtct tccctgtccc aatcgaccag tgtatcgacg gc                         522


<210>  110
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07G09

<400>  110
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctcggcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga caccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt ccagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  111
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07K20

<400>  111
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg aggataagaa tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttaccttcg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga cgccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgccaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  112
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07K21

<400>  112
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg agggtaggga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga caccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  113
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07G09_N65D

<400>  113
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctcggcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga caccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt ccagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  114
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07K20_N65D

<400>  114
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg aggataagaa tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttaccttcg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga cgccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgccaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  115
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07K21_N65D

<400>  115
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctctgcgtg agggtaggga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga caccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt tcagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  116
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0530.07G09_H28Q_N65D

<400>  116
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaagggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

gctcggcgtg aggataagga tccgatgaaa atgatggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgaggtgagg tttaggcata agaaatgcaa gtacgatatt      240

gttacctttg tgccggggag ccagccgggc gagtttactt taggccttat taaaagtgat      300

ccgggccaga caccagagtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agaaggtggt ccagaaccgc gagtattttt ggatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  117
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0455.04F12

<400>  117
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcctggc cggaaatatc      120

ctgctgcgtg aggataagga tccgcacaaa atgctggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccacgtgacc tttaaatgga agaaatgcta ctacgcaatt      240

cgtacctttg tgccggggag ccagccgggc gagtttactt taggcatgat taaaagtgag      300

ccgggccaca catcaatgtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtgggtgga ccagaaccgc gaggagtttc tgatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  118
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0455.04F23

<400>  118
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccacgc cggaaatcaa      120

tggctgcgtg aggataagga tccgcgtaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtggac tttgcaatca agaaatgcca ctaccgtatt      240

accacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtcac      300

ccgggcggaa catcaggatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agttcgtgat ccagaaccgc gaggcatttt tcatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  119
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0455.04F09

<400>  119
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcatggc cggaaatttc      120

cacctgcgtg aggataagga tccgagcaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccacgtgcct ttttgggcaa agaaatgcgc atacaaaatt      240

atcacctttg tgccggggag ccagccgggc gagtttactt taggcgcaat taaaagtgga      300

ccgggcatga catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agggagtgtg gcagaaccgc gagacctttg ttatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  120
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0455.04M08

<400>  120
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgttgc cggaaattac      120

tggctgcgtg aggataagga tccggcaaaa atgtacgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtgcgt ttttggcgta agaaatgccg ttacgacatt      240

tggacctttg tgccggggag ccagccgggc gagtttactt taggccctat taaaagtgag      300

ccgggccaaa catcacggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agctggtgcg tcagaaccgc gaggcattta atatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  121
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0522.15K24

<400>  121
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcc tgggcatggc cggaaatttc      120

cacctgcgtg aggataagga tccgagcaag atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccacgtgcct ttttgggcaa agaaatgcgc atacaaaact      240

atcacctttg tgccggggag ccagccgggc gagtttactt taggcgcaat taaaagtgga      300

ccgggcatga catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttctcca agggagtgtg gcagaaccgc gagacctttg ttatcacact gtacgggcgc      420

gcgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  122
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0527.05N11

<400>  122
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcatggc cggaaatttc      120

cacctgcgtg aggataagga tccgagcaaa atgcctgcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccacgtgcct ttttgggcaa agaaatgcgc atacaaaact      240

atcacctttg tgccggggag ccagccgggc gagtttactt taggcgcaat taaaagtgga      300

ccgggcatga catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttctcca agggagtgtg gcagaaccgt gagacctttg ttatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  123
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0522.05A05

<400>  123
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccacgc cggaaatcaa      120

tggctgcgtg agggtaggga tccgcgtaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtggac tttgcaatca agaaatgcct ctaccgtatt      240

accacctttg tgccagggag ccagccgggc gagtttactt taggcaatat taaaagtcac      300

ccgggcggaa catcaggatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agttcgtgat ccagaaccgc gaggcatttt tcatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  124
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0522.05M06

<400>  124
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccacgc cggaaatcaa      120

tggctgcgtg gggattacga tccgcgtaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac cgacgtggac tttgcaatcg agaaatgcca ctaccgtatt      240

accacctttg tgccggggag ccagccgggc gagtttactt ttggcaatat aaaaagtcac      300

ccgggcggaa catcaggatt ggcccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agttcgtgat ccagaaccgc gaggcatttt tcatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  125
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0522.05A05_H28Q_N65D

<400>  125
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaagggaaa tggtatgtcg tgggccacgc cggaaatcaa      120

tggctgcgtg agggtaggga tccgcgtaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgacgtggac tttgcaatca agaaatgcct ctaccgtatt      240

accacctttg tgccagggag ccagccgggc gagtttactt taggcaatat taaaagtcac      300

ccgggcggaa catcaggatt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agttcgtgat ccagaaccgc gaggcatttt tcatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  126
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0522.05M06_N65D

<400>  126
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccacgc cggaaatcaa      120

tggctgcgtg gggattacga tccgcgtaaa atgtgggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cgacgtggac tttgcaatcg agaaatgcca ctaccgtatt      240

accacctttg tgccggggag ccagccgggc gagtttactt ttggcaatat aaaaagtcac      300

ccgggcggaa catcaggatt ggcccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agttcgtgat ccagaaccgc gaggcatttt tcatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal sequence of muteins

<400>  127

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SA linker and the Strep Tag II

<400>  128

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  129
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Expressed protein amino acid sequence

<400>  129

Met Lys His His His His His His Asp Tyr Asp Ile Pro Thr Thr Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
            20                  25                  30          


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
        35                  40                  45              


Phe His Gly Lys Trp Tyr Val Val Gly Val Ala Gly Asn Thr Ile Leu 
    50                  55                  60                  


Arg Glu Asp Lys Asp Pro Gly Lys Met Asn Ala Thr Ile Tyr Glu Leu 
65                  70                  75                  80  


Lys Glu Asp Lys Ser Tyr Asn Val Thr Asp Val Arg Phe Ile Arg Lys 
                85                  90                  95      


Lys Cys His Tyr Tyr Ile Asp Thr Phe Val Pro Gly Ser Gln Pro Gly 
            100                 105                 110         


Glu Phe Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln 
        115                 120                 125             


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
    130                 135                 140                 


Phe Lys Ile Val Arg Gln Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr 
145                 150                 155                 160 


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
                165                 170                 175     


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
            180                 185                 190         


Pro Ile Asp Gln Cys Ile Asp Gly 
        195                 200 


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  positions 95-98

<400>  130

Gly Asn Ile Lys 
1               


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  examples of albumin binding peptides


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any of Asp, Asn, Ser, Thr, or Trp

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any of Asn, Gln, His, Ile, Leu, or Lys

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any of Ala, Asp, Phe, Trp, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any of Asp, Gly, Leu, Phe, Ser, or Thr

<400>  131

Cys Xaa Xaa Xaa Xaa Cys 
1               5       


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  132

Asp Tyr Asp Ile Pro Thr Thr 
1               5           


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  133

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  134
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_H28Q_T54A_N65D_(G4S)2S0544.04C04_H28Q_N65D_(G4S)2 
       S0530.07G09_H28Q_N65D_(G4S)2 S0522.05A05_H28Q_N65D

<400>  134

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Asn Thr Ala Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe Gln Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu 
        595                 600                 605             


Gly Arg Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys 
625                 630                 635                 640 


Leu Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly 
            740         


<210>  135
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65D_(G4S)2S0530.04N16_N65D_(G4S)2 
       S0530.07G09_N65D_(G4S)2 S0522.05M06_N65D

<400>  135

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly 
        595                 600                 605             


Asp Tyr Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Phe Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly 
            740         


<210>  136
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_H28Q_T54A_N65D(G4S)2S0544.04C04_H28Q_N65D(G4S)2 
       S0530.07G09_H28Q_N65D_(G4S)2 S0522.05A05_H28Q_N65D_(G4S)2 
       huIgG4Fc

<400>  136

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Asn Thr Ala Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe Gln Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu 
        595                 600                 605             


Gly Arg Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys 
625                 630                 635                 640 


Leu Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
        755                 760                 765             


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    770                 775                 780                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
785                 790                 795                 800 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
                805                 810                 815     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
            820                 825                 830         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        835                 840                 845             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
    850                 855                 860                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
865                 870                 875                 880 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
                885                 890                 895     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            900                 905                 910         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        915                 920                 925             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
    930                 935                 940                 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
945                 950                 955                 960 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                965                 970                 975     


Leu Ser Leu Gly 
            980 


<210>  137
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65D_(G4S)2 S0530.04N16_N65D_(G4S)2_ 
       S0530.07G09_N65D_(G4S)2_ S0522.05M06_N65D_(G4S)2_hIgG4Fc

<400>  137

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly 
        595                 600                 605             


Asp Tyr Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Phe Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
        755                 760                 765             


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    770                 775                 780                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
785                 790                 795                 800 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
                805                 810                 815     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
            820                 825                 830         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        835                 840                 845             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
    850                 855                 860                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
865                 870                 875                 880 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
                885                 890                 895     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            900                 905                 910         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        915                 920                 925             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
    930                 935                 940                 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
945                 950                 955                 960 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                965                 970                 975     


Leu Ser Leu Gly 
            980 


<210>  138
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4Fc_(G4S)2_S0474.01H22_T54A_N65D_(G4S)2S0530.04N16_N65D_(G4S)
       2_S0530.07G09_N65D_(G4S)2_ S0522.05M06_N65D

<400>  138

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp 
225                 230                 235                 240 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                245                 250                 255     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            260                 265                 270         


Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro Gly Lys 
        275                 280                 285             


Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val 
    290                 295                 300                 


Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile Asp Thr 
305                 310                 315                 320 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn Ile Lys 
                325                 330                 335     


Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn 
            340                 345                 350         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln Asn Arg 
        355                 360                 365             


Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    370                 375                 380                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
385                 390                 395                 400 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp 
            420                 425                 430         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        435                 440                 445             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    450                 455                 460                 


Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met Ala Ala 
465                 470                 475                 480 


Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp 
                485                 490                 495     


Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val Pro Gly 
            500                 505                 510         


Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly 
        515                 520                 525             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    530                 535                 540                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
545                 550                 555                 560 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                565                 570                 575     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            580                 585                 590         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    610                 615                 620                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
625                 630                 635                 640 


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Arg 
                645                 650                 655     


Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu 
            660                 665                 670         


Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg His Lys 
        675                 680                 685             


Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly 
    690                 695                 700                 


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu 
705                 710                 715                 720 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                725                 730                 735     


Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr 
            740                 745                 750         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        755                 760                 765             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    770                 775                 780                 


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
                805                 810                 815     


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
            820                 825                 830         


Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly Asp Tyr 
        835                 840                 845             


Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
    850                 855                 860                 


Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys His Tyr 
865                 870                 875                 880 


Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe 
                885                 890                 895     


Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala Arg Val 
            900                 905                 910         


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val 
        915                 920                 925             


Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys 
    930                 935                 940                 


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
945                 950                 955                 960 


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
                965                 970                 975     


Cys Ile Asp Gly 
            980 


<210>  139
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22_T54A_N65D_(G4S)2S0530.04N16_N65D_(G4S)2_hIgG4Fc_S0530
       .07G09_N65D_(G4S)2 S0522.05M06_N65D

<400>  139

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
    370                 375                 380                 


Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
385                 390                 395                 400 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                405                 410                 415     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            420                 425                 430         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        435                 440                 445             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    450                 455                 460                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
465                 470                 475                 480 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                485                 490                 495     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            500                 505                 510         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        515                 520                 525             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    530                 535                 540                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
545                 550                 555                 560 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                565                 570                 575     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            580                 585                 590         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    610                 615                 620                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
625                 630                 635                 640 


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Arg 
                645                 650                 655     


Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu 
            660                 665                 670         


Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg His Lys 
        675                 680                 685             


Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly 
    690                 695                 700                 


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu 
705                 710                 715                 720 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                725                 730                 735     


Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr 
            740                 745                 750         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        755                 760                 765             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    770                 775                 780                 


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
                805                 810                 815     


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
            820                 825                 830         


Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly Asp Tyr 
        835                 840                 845             


Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
    850                 855                 860                 


Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys His Tyr 
865                 870                 875                 880 


Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Phe 
                885                 890                 895     


Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala Arg Val 
            900                 905                 910         


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val 
        915                 920                 925             


Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys 
    930                 935                 940                 


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
945                 950                 955                 960 


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
                965                 970                 975     


Cys Ile Asp Gly 
            980 


<210>  140
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4-Fc

<400>  140


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  141

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  142
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  142

Gly Ser Gly Gly Ser Gly 
1               5       


<210>  143
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(H28Q;T54A;N65D) (G4S)2 S0544.04C04(H28Q;N65D) (G4S)2 
       (FC;HuIgG4) (G4S)2  S0530.07G09(H28Q;N65D) (G4S)2 
       S0522.05A05(H28Q;N65D)

<400>  143

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Asn Thr Ala Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Val Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Glu Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Thr Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
    370                 375                 380                 


Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
385                 390                 395                 400 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                405                 410                 415     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            420                 425                 430         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        435                 440                 445             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    450                 455                 460                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
465                 470                 475                 480 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                485                 490                 495     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            500                 505                 510         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        515                 520                 525             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    530                 535                 540                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
545                 550                 555                 560 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                565                 570                 575     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            580                 585                 590         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    610                 615                 620                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
625                 630                 635                 640 


Phe Gln Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Arg 
                645                 650                 655     


Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu 
            660                 665                 670         


Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg His Lys 
        675                 680                 685             


Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly 
    690                 695                 700                 


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu 
705                 710                 715                 720 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                725                 730                 735     


Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr 
            740                 745                 750         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        755                 760                 765             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    770                 775                 780                 


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
                805                 810                 815     


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys 
            820                 825                 830         


Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Gly Arg 
        835                 840                 845             


Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
    850                 855                 860                 


Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys Leu Tyr 
865                 870                 875                 880 


Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
                885                 890                 895     


Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val 
            900                 905                 910         


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val 
        915                 920                 925             


Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys 
    930                 935                 940                 


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
945                 950                 955                 960 


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
                965                 970                 975     


Cys Ile Asp Gly 
            980 


<210>  144
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(T54A;N65D) GQPKAAPS S0530.04N16(N65D) GQPKAAPS 
       S0530.07G09(N65Q) GQPKAAPS S0522.05A05(N65D) Cterm StrepII 6His

<400>  144

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met Ala Ala 
225                 230                 235                 240 


Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys 
        355                 360                 365             


Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Arg Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys 
        435                 440                 445             


Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly His Ala Gly Asn Gln Trp Leu Arg Glu Gly Arg Asp Pro Arg Lys 
        595                 600                 605             


Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val 
    610                 615                 620                 


Thr Asp Val Asp Phe Ala Ile Lys Lys Cys Leu Tyr Arg Ile Thr Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn Ile Lys 
                645                 650                 655     


Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln Asn Arg 
        675                 680                 685             


Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  145
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(T54A;N65D) GSGGSG S0530.04N16(N65D) GSGGSG 
       S0530.07G09(N65Q) GSGGSG S0522.05A05(N65D) Cterm StrepII 6His

<400>  145

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Ser Gly Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile 
            180                 185                 190         


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
        195                 200                 205             


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly 
    210                 215                 220                 


Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met Ala Ala Val Tyr 
225                 230                 235                 240 


Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu 
                245                 250                 255     


Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val Pro Gly Asn Gln 
            260                 265                 270         


Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr 
        275                 280                 285             


Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
    290                 295                 300                 


Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr 
305                 310                 315                 320 


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
                325                 330                 335     


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
            340                 345                 350         


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Ser Gly Gly Ser Gly 
        355                 360                 365             


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
    370                 375                 380                 


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
385                 390                 395                 400 


Val Val Gly Glu Ala Gly Asn Leu Ala Arg Arg Glu Asp Lys Asp Pro 
                405                 410                 415     


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
            420                 425                 430         


Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Lys Tyr Asp Ile 
        435                 440                 445             


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
    450                 455                 460                 


Ile Lys Ser Asp Pro Gly Gln Thr Pro Glu Leu Val Arg Val Val Ser 
465                 470                 475                 480 


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
                485                 490                 495     


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
            500                 505                 510         


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
        515                 520                 525             


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
    530                 535                 540                 


Asp Gly Gly Ser Gly Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile 
545                 550                 555                 560 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
                565                 570                 575     


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln 
            580                 585                 590         


Trp Leu Arg Glu Gly Arg Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr 
        595                 600                 605             


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala 
    610                 615                 620                 


Ile Lys Lys Cys Leu Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln 
625                 630                 635                 640 


Pro Gly Glu Phe Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr 
                645                 650                 655     


Ser Gly Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
            660                 665                 670         


Val Phe Phe Lys Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr 
        675                 680                 685             


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
    690                 695                 700                 


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
705                 710                 715                 720 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro 
                725                 730                 735     


Gln Phe Glu Lys His His His His His His 
            740                 745     


<210>  146
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(T54A;N65D) (G4S)2 S0530.04N16(N65D) (G4S)2 
       S0530.07G09(N65Q) (G4S)2 S0522.05A05(N65D) Cterm StrepII 6His

<400>  146

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu 
        595                 600                 605             


Gly Arg Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys 
625                 630                 635                 640 


Leu Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  147
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) (G4S)2 S0530.04N16(N65Q) (G4S)2 
       S0530.07K20(N65Q) (G4S)2 S0522.15K24(N65Q) Cterm StrepII His

<400>  147

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Gln Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asn Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Pro Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Leu Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Thr Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Ala Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  148
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) (G4S)2 S0530.04N16(N65Q) (G4S)2 
       S0530.07K20(N65Q) (G4S)2 S0522.05M06 (N65Q) Cterm StrepII His

<400>  148

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Gln Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asn Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Pro Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly 
        595                 600                 605             


Asp Tyr Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Gln Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Phe Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  149
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) (G4S)2 S0530.04N16(N65Q) (G4S)2 
       S0530.07G09(N65Q) (G4S)2 S0522.15K24(N65Q) Cterm StrepII His

<400>  149

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Gln Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Leu Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Thr Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Ala Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  150
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0530.04N16(N65D) (G4S)2 
       S0530.07K20(N65D) (G4S)2 S0522.15K24(N65D) Cterm StrepII His

<400>  150

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asn Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Pro Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Leu Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Thr Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Ala Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  151
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0530.04N16(N65D) (G4S)2 
       S0530.07K20(N65D) (G4S)2 S0522.05M06 (N65D) Cterm StrepII His

<400>  151

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asn Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Pro Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly 
        595                 600                 605             


Asp Tyr Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Phe Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  152
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0530.04N16(N65D) (G4S)2 
       S0530.07G09(N65D) (G4S)2 S0522.15K24(N65D) Cterm StrepII His

<400>  152

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Leu Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Thr Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Ser Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Ala Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  153
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0530.04N16(N65D) (G4S)2 
       S0530.07G09(N65D) (G4S)2 S0522.05M06 (N65D) Cterm StrepII His

<400>  153

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Glu Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Ala Val Tyr Glu Leu Arg Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Glu Glu Cys Arg Tyr Met Thr Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Asn Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Arg Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Pro Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Gly 
        595                 600                 605             


Asp Tyr Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Glu Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Phe Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Ala 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  154
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GQPKAAPS S0466.09E05(N65Q) GQPKAAPS 
       S0466.13C10(N65Q) GQPKAAPS S0455.04F09(N65Q) StrepII, His6

<400>  154

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr 
225                 230                 235                 240 


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys 
        355                 360                 365             


Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys 
        435                 440                 445             


Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys 
        595                 600                 605             


Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val 
    610                 615                 620                 


Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys 
                645                 650                 655     


Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg 
        675                 680                 685             


Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  155
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GQPKAAPS S0466.09E05(N65Q) GQPKAAPS 
       S0466.13C10(N65Q) GQPKAAPS S0455.04F09(N65Q) StrepII, His6

<400>  155

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr 
225                 230                 235                 240 


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys 
        355                 360                 365             


Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys 
        435                 440                 445             


Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys 
        595                 600                 605             


Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val 
    610                 615                 620                 


Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys 
                645                 650                 655     


Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg 
        675                 680                 685             


Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  156
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) ASTKGP  S0466.09E05(N65Q) ASTKGP  
       S0466.13C10(N65Q) ASTKGP  S0455.04F09(N65Q) StrepII, His6

<400>  156

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Ala Ser Thr Lys Gly Pro Gln Asp Ser Thr Ser Asp Leu Ile 
            180                 185                 190         


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
        195                 200                 205             


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly 
    210                 215                 220                 


Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile Tyr 
225                 230                 235                 240 


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe Glu 
                245                 250                 255     


Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln 
            260                 265                 270         


Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp Thr 
        275                 280                 285             


Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
    290                 295                 300                 


Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr 
305                 310                 315                 320 


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
                325                 330                 335     


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
            340                 345                 350         


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ala Ser Thr Lys Gly Pro 
        355                 360                 365             


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
    370                 375                 380                 


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
385                 390                 395                 400 


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
                405                 410                 415     


Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
            420                 425                 430         


Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr Asp Ile 
        435                 440                 445             


Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
    450                 455                 460                 


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
465                 470                 475                 480 


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
                485                 490                 495     


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
            500                 505                 510         


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
        515                 520                 525             


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
    530                 535                 540                 


Asp Gly Ala Ser Thr Lys Gly Pro Gln Asp Ser Thr Ser Asp Leu Ile 
545                 550                 555                 560 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
                565                 570                 575     


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe 
            580                 585                 590         


His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr 
        595                 600                 605             


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp 
    610                 615                 620                 


Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln 
625                 630                 635                 640 


Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr 
                645                 650                 655     


Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
            660                 665                 670         


Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr 
        675                 680                 685             


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
    690                 695                 700                 


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
705                 710                 715                 720 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro 
                725                 730                 735     


Gln Phe Glu Lys His His His His His His 
            740                 745     


<210>  157
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) ASTKGPS S0466.09E05(N65Q) ASTKGPS 
       S0466.13C10(N65Q) ASTKGPS S0455.04F09(N65Q) StrepII, His6

<400>  157

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Ala Ser Thr Lys Gly Pro Ser Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ala Ser Thr Lys Gly 
        355                 360                 365             


Pro Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr 
        435                 440                 445             


Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Ala Ser Thr Lys Gly Pro Ser Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  158
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) QPKAAP S0466.09E05(N65Q) QPKAAP 
       S0466.13C10(N65Q) QPKAAP S0455.04F09(N65Q) StrepII, His6

<400>  158

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gln Pro Lys Ala Ala Pro Gln Asp Ser Thr Ser Asp Leu Ile 
            180                 185                 190         


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
        195                 200                 205             


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly 
    210                 215                 220                 


Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile Tyr 
225                 230                 235                 240 


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe Glu 
                245                 250                 255     


Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln 
            260                 265                 270         


Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp Thr 
        275                 280                 285             


Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
    290                 295                 300                 


Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr 
305                 310                 315                 320 


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
                325                 330                 335     


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
            340                 345                 350         


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gln Pro Lys Ala Ala Pro 
        355                 360                 365             


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
    370                 375                 380                 


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
385                 390                 395                 400 


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
                405                 410                 415     


Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
            420                 425                 430         


Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr Asp Ile 
        435                 440                 445             


Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
    450                 455                 460                 


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
465                 470                 475                 480 


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
                485                 490                 495     


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
            500                 505                 510         


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
        515                 520                 525             


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
    530                 535                 540                 


Asp Gly Gln Pro Lys Ala Ala Pro Gln Asp Ser Thr Ser Asp Leu Ile 
545                 550                 555                 560 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
                565                 570                 575     


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe 
            580                 585                 590         


His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr 
        595                 600                 605             


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp 
    610                 615                 620                 


Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln 
625                 630                 635                 640 


Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr 
                645                 650                 655     


Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
            660                 665                 670         


Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr 
        675                 680                 685             


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
    690                 695                 700                 


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
705                 710                 715                 720 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro 
                725                 730                 735     


Gln Phe Glu Lys His His His His His His 
            740                 745     


<210>  159
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GQPKAAP S0466.09E05(N65Q) GQPKAAP 
       S0466.13C10(N65Q) GQPKAAP S0455.04F09(N65Q) StrepII, His6

<400>  159

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Pro Lys Ala Ala Pro Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys Ala 
        355                 360                 365             


Ala Pro Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr 
        435                 440                 445             


Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Gly Gln Pro Lys Ala Ala Pro Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  160
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GQPKAAPS S0466.09E05(N65Q) GQPKAAPS 
       S0466.13C10(N65Q) GQPKAAPS S0455.04F09(N65Q) StrepII, His6

<400>  160

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr 
225                 230                 235                 240 


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys 
        355                 360                 365             


Ala Ala Pro Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys 
        435                 440                 445             


Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gln Pro Lys Ala Ala Pro Ser Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys 
        595                 600                 605             


Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val 
    610                 615                 620                 


Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys 
                645                 650                 655     


Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg 
        675                 680                 685             


Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  161
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GGSGG S0466.09E05(N65Q) GGSGG 
       S0466.13C10(N65Q) GGSGG S0455.04F09(N65Q) StrepII, His6

<400>  161

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro 
            180                 185                 190         


Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn 
        195                 200                 205             


Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp 
    210                 215                 220                 


Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile Tyr Glu 
225                 230                 235                 240 


Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe Glu Leu 
                245                 250                 255     


Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro 
            260                 265                 270         


Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp Thr Ser 
        275                 280                 285             


Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val 
    290                 295                 300                 


Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu 
305                 310                 315                 320 


Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile 
                325                 330                 335     


Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro 
            340                 345                 350         


Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Gln Asp 
        355                 360                 365             


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
    370                 375                 380                 


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
385                 390                 395                 400 


Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys 
                405                 410                 415     


Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val 
            420                 425                 430         


Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr Asp Ile Ala Thr 
        435                 440                 445             


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys 
    450                 455                 460                 


Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser Thr Asn 
465                 470                 475                 480 


Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln Asn Arg 
                485                 490                 495     


Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
            500                 505                 510         


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
        515                 520                 525             


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro 
545                 550                 555                 560 


Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe 
                565                 570                 575     


His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg 
            580                 585                 590         


Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys 
        595                 600                 605             


Glu Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys 
    610                 615                 620                 


Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu 
625                 630                 635                 640 


Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu 
                645                 650                 655     


Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe 
            660                 665                 670         


Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly 
        675                 680                 685             


Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe 
    690                 695                 700                 


Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro 
705                 710                 715                 720 


Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu 
                725                 730                 735     


Lys His His His His His His 
            740             


<210>  162
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A)SGGSG S0466.09E05(N65Q) SGGSG 
       S0466.13C10(N65Q) SGGSG S0455.04F09(N65Q) StrepII, His6

<400>  162

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr 
        435                 440                 445             


Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  163
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GGGSGGG S0466.09E05(N65Q) GGGSGGG 
       S0466.13C10(N65Q) GGGSGGG S0455.04F09(N65Q) StrepII, His6

<400>  163

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys Gln Tyr 
        435                 440                 445             


Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  164
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A)GGSGGSGG S0466.09E05(N65Q) GGSGGSGG 
       S0466.13C10(N65Q)GGSGGSGG S0455.04F09(N65Q) StrepII, His6

<400>  164

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala Thr 
225                 230                 235                 240 


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys Lys Cys 
        435                 440                 445             


Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys 
        595                 600                 605             


Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val 
    610                 615                 620                 


Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys 
                645                 650                 655     


Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg 
        675                 680                 685             


Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  165
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) GGGSGGSGGG  S0466.09E05(N65Q) GGGSGGSGGG  
       S0466.13C10(N65Q) GGGSGGSGGG  S0455.04F09(N65Q) StrepII, His6

<400>  165

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser 
            180                 185                 190         


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
        195                 200                 205             


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala 
    210                 215                 220                 


Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala 
225                 230                 235                 240 


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val 
                245                 250                 255     


Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro 
            260                 265                 270         


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro 
        275                 280                 285             


Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
    290                 295                 300                 


His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe 
305                 310                 315                 320 


His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
                325                 330                 335     


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
            340                 345                 350         


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    370                 375                 380                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
385                 390                 395                 400 


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu 
                405                 410                 415     


Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu 
            420                 425                 430         


Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys 
        435                 440                 445             


Lys Cys Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly 
    450                 455                 460                 


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu 
465                 470                 475                 480 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                485                 490                 495     


Phe Lys Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr 
            500                 505                 510         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        515                 520                 525             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    530                 535                 540                 


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
                565                 570                 575     


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp 
            580                 585                 590         


Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp 
        595                 600                 605             


Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
    610                 615                 620                 


Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys 
625                 630                 635                 640 


Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
                645                 650                 655     


Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val 
            660                 665                 670         


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp 
        675                 680                 685             


Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
    690                 695                 700                 


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
705                 710                 715                 720 


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
                725                 730                 735     


Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His 
            740                 745                 750         


His His His 
        755 


<210>  166
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A)GGGSGGSGGG S0466.09E05(N65Q) GGGSGGSGGG 
       S0466.13C10(N65Q)GGGSGGSGGG S0455.04F09(N65Q) StrepII, His6

<400>  166

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser 
            180                 185                 190         


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
        195                 200                 205             


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala 
    210                 215                 220                 


Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met Ala 
225                 230                 235                 240 


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val Val 
                245                 250                 255     


Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro 
            260                 265                 270         


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe Pro 
        275                 280                 285             


Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
    290                 295                 300                 


His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe 
305                 310                 315                 320 


His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
                325                 330                 335     


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
            340                 345                 350         


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    370                 375                 380                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
385                 390                 395                 400 


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu 
                405                 410                 415     


Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr Glu Leu 
            420                 425                 430         


Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg His Lys 
        435                 440                 445             


Lys Cys Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln Pro Gly 
    450                 455                 460                 


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu 
465                 470                 475                 480 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                485                 490                 495     


Phe Lys Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr 
            500                 505                 510         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        515                 520                 525             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    530                 535                 540                 


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
                565                 570                 575     


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp 
            580                 585                 590         


Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp 
        595                 600                 605             


Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
    610                 615                 620                 


Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys 
625                 630                 635                 640 


Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
                645                 650                 655     


Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val 
            660                 665                 670         


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp 
        675                 680                 685             


Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
    690                 695                 700                 


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
705                 710                 715                 720 


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
                725                 730                 735     


Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His 
            740                 745                 750         


His His His 
        755 


<210>  167
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) S0510.05H10(N65D) S0510.11H24(N65D) 
       S0455.04F09(N65D) StrepII His tag

<400>  167

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
            180                 185                 190         


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
        195                 200                 205             


Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys 
    210                 215                 220                 


Asp Pro Leu Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
225                 230                 235                 240 


Ser Tyr Asp Val Thr Val Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr 
                245                 250                 255     


Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
            260                 265                 270         


Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg Val 
        275                 280                 285             


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val 
    290                 295                 300                 


Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr Lys 
305                 310                 315                 320 


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
                325                 330                 335     


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
            340                 345                 350         


Cys Ile Asp Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
        355                 360                 365             


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
    370                 375                 380                 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
385                 390                 395                 400 


Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
                405                 410                 415     


Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys 
            420                 425                 430         


Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
        435                 440                 445             


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
    450                 455                 460                 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
465                 470                 475                 480 


Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg 
                485                 490                 495     


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
            500                 505                 510         


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
        515                 520                 525             


Asp Gln Cys Ile Asp Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
    530                 535                 540                 


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
545                 550                 555                 560 


Phe His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu 
                565                 570                 575     


Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu 
            580                 585                 590         


Lys Glu Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys 
        595                 600                 605             


Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly 
    610                 615                 620                 


Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp 
625                 630                 635                 640 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
                645                 650                 655     


Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr 
            660                 665                 670         


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
        675                 680                 685             


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
    690                 695                 700                 


Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe 
705                 710                 715                 720 


Glu Lys His His His His His His 
                725             


<210>  168
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G) S0510.05H10(N65D) (G) 
       S0510.11H24(N65D) (G) S0455.04F09(N65D) StrepII His tag

<400>  168

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
            180                 185                 190         


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
        195                 200                 205             


Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg Glu Asp 
    210                 215                 220                 


Lys Asp Pro Leu Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
225                 230                 235                 240 


Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu Leu Lys Lys Cys Arg 
                245                 250                 255     


Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
            260                 265                 270         


Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu Val Arg 
        275                 280                 285             


Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly 
    290                 295                 300                 


Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly Arg Thr 
305                 310                 315                 320 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
                325                 330                 335     


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
            340                 345                 350         


Gln Cys Ile Asp Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
        355                 360                 365             


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
    370                 375                 380                 


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu 
385                 390                 395                 400 


Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu 
                405                 410                 415     


Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg Gln Lys 
            420                 425                 430         


Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly 
        435                 440                 445             


Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu 
    450                 455                 460                 


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
465                 470                 475                 480 


Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr 
                485                 490                 495     


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
            500                 505                 510         


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
        515                 520                 525             


Pro Ile Asp Gln Cys Ile Asp Gly Gly Gln Asp Ser Thr Ser Asp Leu 
    530                 535                 540                 


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
545                 550                 555                 560 


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn 
                565                 570                 575     


Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile 
            580                 585                 590         


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe 
        595                 600                 605             


Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser 
    610                 615                 620                 


Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met 
625                 630                 635                 640 


Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
                645                 650                 655     


Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile 
            660                 665                 670         


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
        675                 680                 685             


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
    690                 695                 700                 


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His 
705                 710                 715                 720 


Pro Gln Phe Glu Lys His His His His His His 
                725                 730     


<210>  169
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G)3 S0510.05H10(N65D) (G)3 
       S0510.11H24(N65D) (G)3 S0455.04F09(N65D) StrepII His tag

<400>  169

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro 
            180                 185                 190         


Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe 
        195                 200                 205             


His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp Leu Arg 
    210                 215                 220                 


Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile Tyr Glu Leu Lys 
225                 230                 235                 240 


Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu Leu Lys Lys 
                245                 250                 255     


Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu 
            260                 265                 270         


Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr Ser Gln Leu 
        275                 280                 285             


Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe 
    290                 295                 300                 


Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu Tyr Gly 
305                 310                 315                 320 


Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe 
                325                 330                 335     


Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro 
            340                 345                 350         


Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gln Asp Ser Thr Ser Asp 
        355                 360                 365             


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
    370                 375                 380                 


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly 
385                 390                 395                 400 


Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr 
                405                 410                 415     


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg 
            420                 425                 430         


Phe Arg Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly 
        435                 440                 445             


Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly 
    450                 455                 460                 


Gln Thr Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
465                 470                 475                 480 


Ala Met Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp 
                485                 490                 495     


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
            500                 505                 510         


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
        515                 520                 525             


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gln 
    530                 535                 540                 


Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro 
545                 550                 555                 560 


Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val 
                565                 570                 575     


Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser 
            580                 585                 590         


Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp 
        595                 600                 605             


Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile 
    610                 615                 620                 


Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile 
625                 630                 635                 640 


Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr 
                645                 650                 655     


Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn 
            660                 665                 670         


Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr 
        675                 680                 685             


Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu 
    690                 695                 700                 


Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp 
705                 710                 715                 720 


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His 
                725                 730                 735     


His 
    


<210>  170
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (GSGSG) S0510.05H10(N65D) (GSGSG) 
       S0510.11H24(N65D) (GSGSG) S0455.04F09(N65D) StrepII His tag

<400>  170

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Ser Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro 
            180                 185                 190         


Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn 
        195                 200                 205             


Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp 
    210                 215                 220                 


Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile Tyr Glu 
225                 230                 235                 240 


Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu Leu 
                245                 250                 255     


Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro 
            260                 265                 270         


Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr Ser 
        275                 280                 285             


Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val 
    290                 295                 300                 


Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu 
305                 310                 315                 320 


Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile 
                325                 330                 335     


Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro 
            340                 345                 350         


Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Ser Gly Ser Gly Gln Asp 
        355                 360                 365             


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
    370                 375                 380                 


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
385                 390                 395                 400 


Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro Met Lys 
                405                 410                 415     


Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val 
            420                 425                 430         


Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr 
        435                 440                 445             


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys 
    450                 455                 460                 


Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser Thr Asn 
465                 470                 475                 480 


Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln Asn Arg 
                485                 490                 495     


Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
            500                 505                 510         


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
        515                 520                 525             


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
    530                 535                 540                 


Gly Ser Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro 
545                 550                 555                 560 


Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe 
                565                 570                 575     


His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg 
            580                 585                 590         


Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys 
        595                 600                 605             


Glu Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys 
    610                 615                 620                 


Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu 
625                 630                 635                 640 


Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu 
                645                 650                 655     


Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe 
            660                 665                 670         


Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly 
        675                 680                 685             


Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe 
    690                 695                 700                 


Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro 
705                 710                 715                 720 


Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu 
                725                 730                 735     


Lys His His His His His His 
            740             


<210>  171
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G2SG2) S0510.05H10(N65D) (G2SG2) 
       S0510.11H24(N65D) (G2SG2) S0455.04F09(N65D) StrepII His tag

<400>  171

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro 
            180                 185                 190         


Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn 
        195                 200                 205             


Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly Trp 
    210                 215                 220                 


Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile Tyr Glu 
225                 230                 235                 240 


Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu Leu 
                245                 250                 255     


Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln Pro 
            260                 265                 270         


Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr Ser 
        275                 280                 285             


Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val 
    290                 295                 300                 


Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr Leu 
305                 310                 315                 320 


Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile 
                325                 330                 335     


Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro 
            340                 345                 350         


Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Gln Asp 
        355                 360                 365             


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
    370                 375                 380                 


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
385                 390                 395                 400 


Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro Met Lys 
                405                 410                 415     


Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val 
            420                 425                 430         


Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr 
        435                 440                 445             


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys 
    450                 455                 460                 


Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser Thr Asn 
465                 470                 475                 480 


Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln Asn Arg 
                485                 490                 495     


Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
            500                 505                 510         


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
        515                 520                 525             


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro 
545                 550                 555                 560 


Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe 
                565                 570                 575     


His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg 
            580                 585                 590         


Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys 
        595                 600                 605             


Glu Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys 
    610                 615                 620                 


Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu 
625                 630                 635                 640 


Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu 
                645                 650                 655     


Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe 
            660                 665                 670         


Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly 
        675                 680                 685             


Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe 
    690                 695                 700                 


Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro 
705                 710                 715                 720 


Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu 
                725                 730                 735     


Lys His His His His His His 
            740             


<210>  172
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (GSG2SG) S0510.05H10(N65D) (GSG2SG) 
       S0510.11H24(N65D) (GSG2SG) S0455.04F09(N65D)  StrepII His tag

<400>  172

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Ser Gly Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile 
            180                 185                 190         


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
        195                 200                 205             


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Gly 
    210                 215                 220                 


Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile Tyr 
225                 230                 235                 240 


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe Glu 
                245                 250                 255     


Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser Gln 
            260                 265                 270         


Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp Thr 
        275                 280                 285             


Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
    290                 295                 300                 


Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile Thr 
305                 310                 315                 320 


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
                325                 330                 335     


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
            340                 345                 350         


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Ser Gly Gly Ser Gly 
        355                 360                 365             


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
    370                 375                 380                 


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
385                 390                 395                 400 


Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys Asp Pro 
                405                 410                 415     


Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
            420                 425                 430         


Asp Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr Asp Ile 
        435                 440                 445             


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Leu 
    450                 455                 460                 


Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val Val Ser 
465                 470                 475                 480 


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Val Gln 
                485                 490                 495     


Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
            500                 505                 510         


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
        515                 520                 525             


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
    530                 535                 540                 


Asp Gly Gly Ser Gly Gly Ser Gly Gln Asp Ser Thr Ser Asp Leu Ile 
545                 550                 555                 560 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
                565                 570                 575     


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe 
            580                 585                 590         


His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr 
        595                 600                 605             


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp 
    610                 615                 620                 


Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln 
625                 630                 635                 640 


Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr 
                645                 650                 655     


Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
            660                 665                 670         


Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr 
        675                 680                 685             


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
    690                 695                 700                 


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
705                 710                 715                 720 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro 
                725                 730                 735     


Gln Phe Glu Lys His His His His His His 
            740                 745     


<210>  173
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G2SGSG2) S0510.05H10(N65D) (G2SGSG2) 
       S0510.11H24(N65D) (G2SGSG2) S0455.04F09(N65D) StrepII  His tag

<400>  173

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Ser 
        355                 360                 365             


Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Asp Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr 
        435                 440                 445             


Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Gly Gly Ser Gly Ser Gly Gly Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  174
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G3SG3) S0510.05H10(N65D) (G3SG3) 
       S0510.11H24(N65D) (G3SG3) S0455.04F09(N65D) StrepII His tag

<400>  174

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu 
            180                 185                 190         


Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln 
        195                 200                 205             


Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn 
    210                 215                 220                 


Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr Ile 
225                 230                 235                 240 


Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp Phe 
                245                 250                 255     


Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly Ser 
            260                 265                 270         


Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly Trp 
        275                 280                 285             


Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala 
    290                 295                 300                 


Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His Ile 
305                 310                 315                 320 


Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn 
                325                 330                 335     


Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val 
            340                 345                 350         


Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
    370                 375                 380                 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
385                 390                 395                 400 


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu Asp Lys 
                405                 410                 415     


Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
            420                 425                 430         


Ser Tyr Asp Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys Lys Tyr 
        435                 440                 445             


Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
    450                 455                 460                 


Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val Arg Val 
465                 470                 475                 480 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
                485                 490                 495     


Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys 
            500                 505                 510         


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
        515                 520                 525             


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
    530                 535                 540                 


Cys Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser 
545                 550                 555                 560 


Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn 
                565                 570                 575     


Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Met Ala 
            580                 585                 590         


Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys Met Pro Ala 
        595                 600                 605             


Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr His Val 
    610                 615                 620                 


Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr Phe Val Pro 
625                 630                 635                 640 


Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys Ser Gly Pro 
                645                 650                 655     


Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln 
            660                 665                 670         


His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg Glu Thr Phe 
        675                 680                 685             


Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys 
    690                 695                 700                 


Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His 
705                 710                 715                 720 


Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Ser Ala Trp 
                725                 730                 735     


Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 


<210>  175
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G2SG2SG2) S0510.05H10(N65D) (G2SG2SG2) 
       S0510.11H24(N65D) (G2SG2SG2) S0455.04F09(N65D) StrepII His tag

<400>  175

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp 
            180                 185                 190         


Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe 
        195                 200                 205             


Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu Ala Gly 
    210                 215                 220                 


Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met Ala Thr 
225                 230                 235                 240 


Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val Val Asp 
                245                 250                 255     


Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val Pro Gly 
            260                 265                 270         


Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser Pro Gly 
        275                 280                 285             


Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His 
    290                 295                 300                 


Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp Phe His 
305                 310                 315                 320 


Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu 
                325                 330                 335     


Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile 
            340                 345                 350         


Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Ser Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
    370                 375                 380                 


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
385                 390                 395                 400 


Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Ala Leu Arg Glu 
                405                 410                 415     


Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr Glu Leu Lys Glu 
            420                 425                 430         


Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg Gln Lys Lys Cys 
        435                 440                 445             


Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
    450                 455                 460                 


Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Ser Gly Gly Ser Gly Gly Gln Asp 
545                 550                 555                 560 


Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu 
                565                 570                 575     


Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val 
            580                 585                 590         


Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro Ser Lys 
        595                 600                 605             


Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val 
    610                 615                 620                 


Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile Ile Thr 
625                 630                 635                 640 


Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala Ile Lys 
                645                 650                 655     


Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser Thr Asn 
            660                 665                 670         


Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln Asn Arg 
        675                 680                 685             


Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser 
    690                 695                 700                 


Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro 
705                 710                 715                 720 


Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly 
                725                 730                 735     


Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His His His 
            740                 745                 750         


<210>  176
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G3SG2SG3) S0510.05H10(N65D) (G3SG2SG3) 
       S0510.11H24(N65D) (G3SG2SG3) S0455.04F09(N65D) StrepII His tag

<400>  176

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  177
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0512.17L07(N39S_N65D_T136A) (G4S)2
       S0510.10A04_stop103Q(N65D) (G4S)2-S0455.04F23(N65D) StrepII His 
       tag

<400>  177

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Ser Thr Thr Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Lys Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Ile Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Tyr Lys Lys Cys Gln Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Ser Glu Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
                565                 570                 575     


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            580                 585                 590         


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Asp Lys Asp Pro 
        595                 600                 605             


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    610                 615                 620                 


Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys His Tyr Arg Ile 
625                 630                 635                 640 


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                645                 650                 655     


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser 
            660                 665                 670         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        675                 680                 685             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    690                 695                 700                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
705                 710                 715                 720 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                725                 730                 735     


Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His 
            740                 745                 750         


His His 
        


<210>  178
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0512.17L07(N39S_N65D_T136A) 
       (G4S)2-S0510.10A04_stop103Q(N65D) (G4S)2-S0455.04F09(N65D)StrepII
       His tag

<400>  178

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Ser Thr Thr Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Lys Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Ile Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Tyr Lys Lys Cys Gln Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Ser Glu Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
                565                 570                 575     


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            580                 585                 590         


Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro 
        595                 600                 605             


Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    610                 615                 620                 


Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile 
625                 630                 635                 640 


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                645                 650                 655     


Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser 
            660                 665                 670         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln 
        675                 680                 685             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    690                 695                 700                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
705                 710                 715                 720 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                725                 730                 735     


Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His 
            740                 745                 750         


His His 
        


<210>  179
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0510.05H10(N65D) (G4S)2 
       S0510.10A04_stop103Q(N65D) (G4S)2 S0455.04F23(N65D) StrepII His 
       tag

<400>  179

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Tyr Lys Lys Cys Gln Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Ser Glu Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
                565                 570                 575     


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            580                 585                 590         


Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu Asp Lys Asp Pro 
        595                 600                 605             


Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    610                 615                 620                 


Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys His Tyr Arg Ile 
625                 630                 635                 640 


Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                645                 650                 655     


Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val Arg Val Val Ser 
            660                 665                 670         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Phe Val Ile Gln 
        675                 680                 685             


Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    690                 695                 700                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
705                 710                 715                 720 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                725                 730                 735     


Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His 
            740                 745                 750         


His His 
        


<210>  180
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2-S0510.05H10(N65D) (G4S)2 
       S0510.10A04_stop103Q(N65D) (G4S)2-S0455.04F09(N65D) StrepII His 
       tag

<400>  180

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Tyr Lys Lys Cys Gln Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Ser Glu Pro Gly Gln Thr Ser Glu Leu Val 
465                 470                 475                 480 


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
                485                 490                 495     


Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg 
            500                 505                 510         


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
        515                 520                 525             


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
    530                 535                 540                 


Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
                565                 570                 575     


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            580                 585                 590         


Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu Asp Lys Asp Pro 
        595                 600                 605             


Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    610                 615                 620                 


Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys Ala Tyr Lys Ile 
625                 630                 635                 640 


Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                645                 650                 655     


Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val Arg Val Val Ser 
            660                 665                 670         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Gly Val Trp Gln 
        675                 680                 685             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    690                 695                 700                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
705                 710                 715                 720 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                725                 730                 735     


Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys His His His His 
            740                 745                 750         


His His 
        


<210>  181
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0512.17L07(N39S_N65D_T136A) (G4S)2
       S0510.11H24(N65D) (G4S)2 S0455.04F23(N65D) StrepII His tag

<400>  181

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Ser Thr Thr Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Lys Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Ile Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  182
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0512.17L07(N39S_N65D_T136A) 
       (G4S)2-S0510.11H24(N65D) (G4S)2-S0455.04F09(N65D) StrepII His tag

<400>  182

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Trp 
    210                 215                 220                 


Ala Gly Ser Thr Thr Leu Arg Glu Asp Lys Asp Pro Pro Lys Met Pro 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Asp 
                245                 250                 255     


Val Gln Phe Pro Glu Lys Lys Cys Ile Tyr Ser Thr Ile Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Gln Thr Ser His Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Tyr Val Ile Gln Asn Arg Glu Gly 
305                 310                 315                 320 


Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  183
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A) (G4S)2 S0510.05H10(N65D) (G4S)2 
       S0510.11H24(N65D) (G4S)2 S0455.04F23(N65D) StrepII His tag

<400>  183

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly His Ala Gly Asn Gln Trp Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Arg Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr Asp Val Asp Phe Ala Ile Lys Lys Cys 
625                 630                 635                 640 


His Tyr Arg Ile Thr Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Asn Ile Lys Ser His Pro Gly Gly Thr Ser Gly Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Phe Val Ile Gln Asn Arg Glu Ala Phe Phe Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  184
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65D;T54A)(G4S)2 S0510.05H10(N65D) (G4S)2 
       S0510.11H24(N65D) (G4S)2 S0455.04F09(N65D)StrepII His tag

<400>  184

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Leu Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Ser 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Met Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Asp Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


Gln Lys Lys Cys Lys Tyr Asp Ile Val Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Tyr Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Asp Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  185
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0474.01H22(N65Q;T54A) (G4S)2 S0466.09E05(N65Q) (G4S)2 
       S0466.13C10(N65Q) (G4S)2 S0455.04F09(N65Q) StrepII, His6

<400>  185

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Thr Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Asn Ala Ala Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Asp Val Arg Phe Ile Arg Lys Lys Cys His Tyr Tyr Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Thr Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ile Val Arg Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             


<210>  186
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S0475.06L06(N65Q;S79F) (G4S)2 S0466.09E05(N65Q) (G4S)2 
       S0466.13C10(N65Q) (G4S)2 S0455.04F09(N65Q) StrepII His tag

<400>  186

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Glu Val Leu Arg Asp Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Glu Val Arg Phe His Asn Lys Lys Cys Asn Tyr Phe Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      


Ile Lys Ser Asn Pro Gly Val Thr Ser Met Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Asn Val Lys Gln 
        115                 120                 125             


Asn Arg Glu Gly Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr 
            180                 185                 190         


Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln 
        195                 200                 205             


Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Leu 
    210                 215                 220                 


Ala Gly Asn Gly Trp Leu Arg Glu Asp Lys Asp Pro Val Lys Met Met 
225                 230                 235                 240 


Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Val 
                245                 250                 255     


Val Asp Phe Glu Leu Lys Lys Cys Arg Tyr Met Ile Glu Thr Phe Val 
            260                 265                 270         


Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp Ile Lys Ser Phe 
        275                 280                 285             


Pro Gly Trp Thr Ser Gln Leu Val Arg Val Val Ser Thr Asn Tyr Asn 
    290                 295                 300                 


Gln His Ala Met Val Phe Phe Lys Gly Val Tyr Gln Asn Arg Glu Trp 
305                 310                 315                 320 


Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu 
                325                 330                 335     


Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn 
            340                 345                 350         


His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile 
    370                 375                 380                 


Pro Ala Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp 
385                 390                 395                 400 


Asn Gln Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu 
                405                 410                 415     


Ala Leu Arg Glu Asp Lys Asp Pro Lys Lys Met Met Ala Thr Ile Tyr 
            420                 425                 430         


Glu Leu Lys Glu Asp Lys Ser Tyr Gln Val Thr Glu Val Arg Phe Arg 
        435                 440                 445             


His Lys Lys Cys Gln Tyr Asp Ile Ala Thr Phe Val Pro Gly Ser Gln 
    450                 455                 460                 


Pro Gly Glu Phe Thr Leu Gly Leu Ile Lys Ser Asp Pro Gly Gln Thr 
465                 470                 475                 480 


Ser Glu Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met 
                485                 490                 495     


Val Phe Phe Lys Lys Val Val Gln Asn Arg Glu Phe Phe Trp Ile Thr 
            500                 505                 510         


Leu Tyr Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe 
        515                 520                 525             


Ile Arg Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe 
    530                 535                 540                 


Pro Val Pro Ile Asp Gln Cys Ile Asp Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
                565                 570                 575     


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His 
            580                 585                 590         


Gly Lys Trp Tyr Val Val Gly Met Ala Gly Asn Phe His Leu Arg Glu 
        595                 600                 605             


Asp Lys Asp Pro Ser Lys Met Pro Ala Thr Ile Tyr Glu Leu Lys Glu 
    610                 615                 620                 


Asp Lys Ser Tyr Gln Val Thr His Val Pro Phe Trp Ala Lys Lys Cys 
625                 630                 635                 640 


Ala Tyr Lys Ile Ile Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe 
                645                 650                 655     


Thr Leu Gly Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Trp Leu Val 
            660                 665                 670         


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
        675                 680                 685             


Gly Val Trp Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg 
    690                 695                 700                 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
705                 710                 715                 720 


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
                725                 730                 735     


Asp Gln Cys Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745                 750         


His His His His His His 
        755             