                         SEQUENCE LISTING

<110>  UCB BIOPHARMA sprl
 
<120>  Tau-binding antibodies

<130>  PF0032-WO

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Phe Gln Ala Thr His Asn Pro Tyr Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Gly Phe Ser Leu Thr Ser Asn Asp Ile Ala 
1               5                   10  


<210>  5
<211>  16
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be Ser, Ala, Thr

<400>  5

Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Xaa Ala Val Gln Ser 
1               5                   10                  15      


<210>  6
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  6

His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr 
1               5                   10  


<210>  7
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Asp Ile Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asn Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Met Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Val Arg Gln Pro Leu Gly Lys Gly Leu Val Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ser Ala Val Gln 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Pro Glu Asp Thr Gly Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser 
        115         


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  9

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa can be Ile and Met

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be Ser, Ala, Thr

<400>  10

Glx Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Xaa Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser
        115         


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  11

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ser Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser
        115         


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  12

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ala Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser
        115         


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Thr Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser
        115         


<210>  14
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Thr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  15
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be Ile or Met

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa can be Ser Ala or Thr

<400>  15

Glx Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Xaa Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  16
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  16

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ser Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  17
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ala Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  18
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  18

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Thr Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  19
<211>  336
<212>  DNA
<213>  Rattus norvegicus

<400>  19
gatattgtga tgacccagac tccagtttcc ctgtctgtca cacttggaga tcaagcttct       60

atatcttgca ggtctagtca gagcctggaa tatagtgatg gctacactta tttggaatgg      120

tacctacaga agccaggcca gtctcctcag ctcctcatct atgaagtttc caaccgattt      180

tctggggtcc cagacaggtt cattggcagt gggtcaggga cagatttcac cctcaagatc      240

agcagagtag agcctgagga cttgggagtt tattactgct tccaagctac acataatccg      300

tacacgtttg gagctgggac caagctggaa ataaaa                                336


<210>  20
<211>  354
<212>  DNA
<213>  Rattus norvegicus

<400>  20
gaggtgaagc tggaggagtc tggacctggc ttgatgcagc cctcagagac cctgtccctc       60

acctgcactg tctctggctt ctcactaacc agcaatgata tagcctgggt tcgacaacct      120

ctaggaaagg gtttggtgtg gatgggaaca atatggactg atggaagtac aaattataat      180

tcagctgtcc aatcccgact gagcatcagc agggacacct ccaagagcca atttttctta      240

aaaatgaaca gtctgcaacc tgaagacaca ggcacttact actgtgccag acatcgccta      300

tactacgggg cctttgatta ctggggccaa ggaaccatgg tcaccgtctc gagt            354


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  21
gatatcgtga tgactcagac cccactctca ctgtccgtca ccccgggaca gcccgcgtca       60

atctcgtgta ggagctccca atccctcgaa tactcggacg gctatactta cctggagtgg      120

tacttgcaga agcccggaca gagcccgcag cttctgatct acgaagtgtc caacagattc      180

tccggcgtgc ctgaccgctt ttcggggtcg ggctccggta ctgatttcac cctgaaaatc      240

tcccgggtgg aagccgagga cgtgggagtc tactactgct tccaagccac ccacaaccct      300

tacaccttcg gacaggggac caagctggag atcaag                                336


<210>  22
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  22
gaggtgcagc tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

gccgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagt            354


<210>  23
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  23
gaggtgcaac tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

accgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagt            354


<210>  24
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  24
gatatcgtga tgactcagac cccactctca ctgtccgtca ccccgggaca gcccgcgtca       60

atctcgtgta ggagctccca atccctcgaa tactcggacg gctatactta cctggagtgg      120

tacttgcaga agcccggaca gagcccgcag cttctgatct acgaagtgtc caacagattc      180

tccggcgtgc ctgaccgctt ttcggggtcg ggctccggta ctgatttcac cctgaaaatc      240

tcccgggtgg aagccgagga cgtgggagtc tactactgct tccaagccac ccacaaccct      300

tacaccttcg gacaggggac caagctggag atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctt aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  25
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  25
gaggtgcagc tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

gccgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagtgcctcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc cgagtctacc      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgacagt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc ttccctgccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtcgt gaccgtgccc tcctccagcc tgggcaccaa gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agcgggtgga atctaagtac      660

ggccctccct gccccccctg ccctgcccct gaatttctgg gcggaccttc cgtgttcctg      720

ttccccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg      780

gtggtggacg tgtcccagga agatcccgag gtccagttca attggtacgt ggacggcgtg      840

gaagtgcaca atgccaagac caagcccaga gaggaacagt tcaactccac ctaccgggtg      900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag     1020

ccccgcgagc cccaggtgta caccctgccc cctagccagg aagagatgac caagaaccag     1080

gtgtccctga cctgtctggt caagggcttc tacccctccg acattgccgt ggaatgggag     1140

tccaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

tccttcttcc tgtactctcg gctgaccgtg gacaagtccc ggtggcagga aggcaacgtc     1260

ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc     1320

ctgagcctgg gcaag                                                      1335


<210>  26
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  26
gaggtgcaac tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

accgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagtgcctcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc cgagtctacc      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgacagt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc ttccctgccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtcgt gaccgtgccc tcctccagcc tgggcaccaa gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agcgggtgga atctaagtac      660

ggccctccct gccccccctg ccctgcccct gaatttctgg gcggaccttc cgtgttcctg      720

ttccccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg      780

gtggtggacg tgtcccagga agatcccgag gtccagttca attggtacgt ggacggcgtg      840

gaagtgcaca atgccaagac caagcccaga gaggaacagt tcaactccac ctaccgggtg      900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag     1020

ccccgcgagc cccaggtgta caccctgccc cctagccagg aagagatgac caagaaccag     1080

gtgtccctga cctgtctggt caagggcttc tacccctccg acattgccgt ggaatgggag     1140

tccaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

tccttcttcc tgtactctcg gctgaccgtg gacaagtccc ggtggcagga aggcaacgtc     1260

ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc     1320

ctgagcctgg gcaag                                                      1335


<210>  27
<211>  134
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  leader sequence

<400>  27

Met Asp Met Arg Val Pro Ala Gln Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Val Ser 
            20                  25                  30          


Leu Ser Val Thr Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Glu Tyr Ser Asp Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Pro Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Ala Thr His Asn Pro Tyr Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys 
    130                 


<210>  28
<211>  136
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Met Gln 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Asn Asp Ile Ala Trp Val Arg Gln Pro Leu Gly Lys Gly Leu 
    50                  55                  60                  


Val Trp Met Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Val Gln Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Phe Phe Leu Lys Met Asn Ser Leu Gln Pro Glu Asp Thr Gly Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser 
    130                 135     


<210>  29
<211>  402
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  leader sequence

<400>  29
atggacatga gggttcctgc tcaggttttt ggcttcttgt tgctctggtt tccaggcacc       60

aggtgtgata ttgtgatgac ccagactcca gtttccctgt ctgtcacact tggagatcaa      120

gcttctatat cttgcaggtc tagtcagagc ctggaatata gtgatggcta cacttatttg      180

gaatggtacc tacagaagcc aggccagtct cctcagctcc tcatctatga agtttccaac      240

cgattttctg gggtcccaga caggttcatt ggcagtgggt cagggacaga tttcaccctc      300

aagatcagca gagtagagcc tgaggacttg ggagtttatt actgcttcca agctacacat      360

aatccgtaca cgtttggagc tgggaccaag ctggaaataa aa                         402


<210>  30
<211>  411
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  leader sequence

<400>  30
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctaccggtgt ccattctgag       60

gtgaagctgg aggagtctgg acctggcttg atgcagccct cagagaccct gtccctcacc      120

tgcactgtct ctggcttctc actaaccagc aatgatatag cctgggttcg acaacctcta      180

ggaaagggtt tggtgtggat gggaacaata tggactgatg gaagtacaaa ttataattca      240

gctgtccaat cccgactgag catcagcagg gacacctcca agagccaatt tttcttaaaa      300

atgaacagtc tgcaacctga agacacaggc acttactact gtgccagaca tcgcctatac      360

tacggggcct ttgattactg gggccaagga accatggtca ccgtctcgag t               411


<210>  31
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  32
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
            100                 105                 110         


Ser



<210>  33
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  33
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctaatct atgaagtttc cagccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat acaccttcct      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  34
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  34
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatgctttt      300

gatgtctggg gccaagggac aatggtcacc gtctcttca                             339


<210>  35
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  36
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ser Ala Val Gln Ser 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ala Ala Val Gln Ser 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  38

Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Thr Ala Val Gln Ser 
1               5                   10                  15      


<210>  39
<211>  6757
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagatg tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

cgatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa     5160

ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat gggctcaagc     5220

caccaccacc accaccacag cagcggcgag aacttgtact ttcaaggatc cgcagaacca     5280

cgtcaagaat ttgaggttat ggaagatcac gcgggcactt acggtttggg tgatcgtaaa     5340

gaccagggcg gctataccat gcatcaagat caagagggcg acaccgatgc tggcttgaaa     5400

gagtcgccgc tgcagactcc gaccgaggat ggcagcgaag agccgggcag cgagactagc     5460

gatgcgaagt cgaccccgac cgccgaggac gttaccgcac cgctggtcga cgagggtgct     5520

ccgggtaaac aggcggctgc acagccgcac acggagattc cggaaggcac caccgcagaa     5580

gaggcgggta tcggcgacac tccgtccctg gaagatgagg cagccggtca tgtcacgcag     5640

gcgcgtatgg tgagcaagag caaagatggt acgggtagcg acgacaagaa ggcgaagggc     5700

gcagatggca agaccaaaat tgcgacgccg cgtggtgcgg caccgccagg ccagaaaggt     5760

caggcgaatg ccacgcgcat cccggcaaag acgccaccgg ctccgaaaac cccgccttcc     5820

agcggtgaac cgccgaaatc cggtgaccgc agcggttata gctctccggg tagcccgggt     5880

accccaggca gccgtagccg caccccgagc ctgccgaccc caccgacccg cgagccgaag     5940

aaagtggcgg tggttcgtac gccgccaaaa agcccgagct ctgccaagag ccgtctgcaa     6000

accgctcctg tgccgatgcc ggacctgaag aacgttaagt ctaaaatcgg tagcaccgaa     6060

aatctgaagc accaacctgg tggcggtaag gttcaaatca tcaacaaaaa gctggacttg     6120

agcaatgtac aaagcaagtg tggtagcaag gacaatatca aacacgtccc gggtggtggt     6180

tccgtccaga ttgtgtacaa accggtggac ctgagcaagg ttaccagcaa atgcggttcc     6240

ctgggtaaca tccatcataa accgggtggc ggccaagttg aggtcaagag cgagaaactg     6300

gacttcaaag accgcgttca gtccaaaatc ggttctctgg acaacattac gcacgtgcct     6360

ggtggtggca acaagaagat tgaaacccat aaactgacgt ttcgtgaaaa tgcgaaggcg     6420

aaaaccgacc acggcgcaga gattgtctac aaaagcccgg tggtgagcgg tgataccagc     6480

ccgcgtcacc tgtccaacgt cagcagcacg ggcagcattg atatggtgga tagcccgcag     6540

ttggctacgc tggccgatga ggttagcgcg agcctggcga agcagggtct gtgactcgag     6600

caccaccacc accaccactg agatccggct gctaacaaag cccgaaagga agctgagttg     6660

gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg     6720

aggggttttt tgctgaaagg aggaactata tccggat                              6757


<210>  40
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
                85                  90                  95      


Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln 
            100                 105                 110         


Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
        115                 120                 125             


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
    130                 135                 140                 


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
145                 150                 155                 160 


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
                165                 170                 175     


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
            180                 185                 190         


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
        195                 200                 205             


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
    210                 215                 220                 


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
225                 230                 235                 240 


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
                245                 250                 255     


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
            260                 265                 270         


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
        275                 280                 285             


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
    290                 295                 300                 


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
305                 310                 315                 320 


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                325                 330                 335     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            340                 345                 350         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        355                 360                 365             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    370                 375                 380                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
385                 390                 395                 400 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                405                 410                 415     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            420                 425                 430         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        435                 440                 445             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    450                 455                 460     


<210>  41
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala 
1               5                   10                  15      


Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met 
            20                  25                  30          


His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro 
        35                  40                  45              


Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr 
    50                  55                  60                  


Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu 
65                  70                  75                  80  


Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr 
                85                  90                  95      


Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr 
            100                 105                 110         


Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met 
        115                 120                 125             


Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys 
    130                 135                 140                 


Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro 
145                 150                 155                 160 


Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                165                 170                 175     


Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser 
            180                 185                 190         


Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly 
        195                 200                 205             


Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro 
    210                 215                 220                 


Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala 
225                 230                 235                 240 


Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
                245                 250                 255     


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
            260                 265                 270         


Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val 
        275                 280                 285             


Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly 
    290                 295                 300                 


Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
305                 310                 315                 320 


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
                325                 330                 335     


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
            340                 345                 350         


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
        355                 360                 365             


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
    370                 375                 380                 


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
385                 390                 395                 400 


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
                405                 410                 415     


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
            420                 425                 430         


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440         


<210>  42
<211>  6583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagatg tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

cgatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa     5160

ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat gggctcaagc     5220

caccaccacc accaccacag cagcggcgag aacttgtact ttcaaggatc cgcagaacca     5280

cgtcaagaat ttgaggttat ggaagatcac gcgggcactt acggtttggg tgatcgtaaa     5340

gaccagggcg gctataccat gcatcaagat caagagggcg acaccgatgc tggcttgaaa     5400

gcagaagagg cgggtatcgg cgacactccg tccctggaag atgaggcagc cggtcatgtc     5460

acgcaggcgc gtatggtgag caagagcaaa gatggtacgg gtagcgacga caagaaggcg     5520

aagggcgcag atggcaagac caaaattgcg acgccgcgtg gtgcggcacc gccaggccag     5580

aaaggtcagg cgaatgccac gcgcatcccg gcaaagacgc caccggctcc gaaaaccccg     5640

ccttccagcg gtgaaccgcc gaaatccggt gaccgcagcg gttatagctc tccgggtagc     5700

ccgggtaccc caggcagccg tagccgcacc ccgagcctgc cgaccccacc gacccgcgag     5760

ccgaagaaag tggcggtggt tcgtacgccg ccaaaaagcc cgagctctgc caagagccgt     5820

ctgcaaaccg ctcctgtgcc gatgccggac ctgaagaacg ttaagtctaa aatcggtagc     5880

accgaaaatc tgaagcacca acctggtggc ggtaaggttc aaatcatcaa caaaaagctg     5940

gacttgagca atgtacaaag caagtgtggt agcaaggaca atatcaaaca cgtcccgggt     6000

ggtggttccg tccagattgt gtacaaaccg gtggacctga gcaaggttac cagcaaatgc     6060

ggttccctgg gtaacatcca tcataaaccg ggtggcggcc aagttgaggt caagagcgag     6120

aaactggact tcaaagaccg cgttcagtcc aaaatcggtt ctctggacaa cattacgcac     6180

gtgcctggtg gtggcaacaa gaagattgaa acccataaac tgacgtttcg tgaaaatgcg     6240

aaggcgaaaa ccgaccacgg cgcagagatt gtctacaaaa gcccggtggt gagcggtgat     6300

accagcccgc gtcacctgtc caacgtcagc agcacgggca gcattgatat ggtggatagc     6360

ccgcagttgg ctacgctggc cgatgaggtt agcgcgagcc tggcgaagca gggtctgtga     6420

ctcgagcacc accaccacca ccactgagat ccggctgcta acaaagcccg aaaggaagct     6480

gagttggctg ctgccaccgc tgagcaataa ctagcataac cccttggggc ctctaaacgg     6540

gtcttgaggg gttttttgct gaaaggagga actatatccg gat                       6583


<210>  43
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly 
                85                  90                  95      


Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro 
    130                 135                 140                 


Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
145                 150                 155                 160 


Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
                165                 170                 175     


Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
            180                 185                 190         


Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala 
        195                 200                 205             


Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
    210                 215                 220                 


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile 
225                 230                 235                 240 


Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
                245                 250                 255     


Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
            260                 265                 270         


Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
        275                 280                 285             


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
    290                 295                 300                 


Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
305                 310                 315                 320 


Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
                325                 330                 335     


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            340                 345                 350         


Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
        355                 360                 365             


His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser 
    370                 375                 380                 


Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys 
385                 390                 395                 400 


Gln Gly Leu 
            


<210>  44
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala 
1               5                   10                  15      


Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met 
            20                  25                  30          


His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu 
        35                  40                  45              


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
    50                  55                  60                  


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
65                  70                  75                  80  


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
                85                  90                  95      


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
            100                 105                 110         


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
        115                 120                 125             


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
    130                 135                 140                 


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
145                 150                 155                 160 


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
                165                 170                 175     


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
            180                 185                 190         


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
        195                 200                 205             


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
    210                 215                 220                 


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
225                 230                 235                 240 


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
                245                 250                 255     


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
            260                 265                 270         


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
        275                 280                 285             


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
    290                 295                 300                 


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
305                 310                 315                 320 


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
                325                 330                 335     


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
            340                 345                 350         


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
        355                 360                 365             


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380                 


<210>  45
<211>  6490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagatg tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

cgatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa     5160

ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat gggctcaagc     5220

caccaccacc accaccacag cagcggcgag aacttgtact ttcaaggatc cgcagaacca     5280

cgtcaagaat ttgaggttat ggaagatcac gcgggcactt acggtttggg tgatcgtaaa     5340

gaccagggcg gctataccat gcatcaagat caagagggcg acaccgatgc tggcttgaaa     5400

gcagaagagg cgggtatcgg cgacactccg tccctggaag atgaggcagc cggtcatgtc     5460

acgcaggcgc gtatggtgag caagagcaaa gatggtacgg gtagcgacga caagaaggcg     5520

aagggcgcag atggcaagac caaaattgcg acgccgcgtg gtgcggcacc gccaggccag     5580

aaaggtcagg cgaatgccac gcgcatcccg gcaaagacgc caccggctcc gaaaaccccg     5640

ccttccagcg gtgaaccgcc gaaatccggt gaccgcagcg gttatagctc tccgggtagc     5700

ccgggtaccc caggcagccg tagccgcacc ccgagcctgc cgaccccacc gacccgcgag     5760

ccgaagaaag tggcggtggt tcgtacgccg ccaaaaagcc cgagctctgc caagagccgt     5820

ctgcaaaccg ctcctgtgcc gatgccggac ctgaagaacg ttaagtctaa aatcggtagc     5880

accgaaaatc tgaagcacca acctggtggc ggtaaggtcc agattgtgta caaaccggtg     5940

gacctgagca aggttaccag caaatgcggt tccctgggta acatccatca taaaccgggt     6000

ggcggccaag ttgaggtcaa gagcgagaaa ctggacttca aagaccgcgt tcagtccaaa     6060

atcggttctc tggacaacat tacgcacgtg cctggtggtg gcaacaagaa gattgaaacc     6120

cataaactga cgtttcgtga aaatgcgaag gcgaaaaccg accacggcgc agagattgtc     6180

tacaaaagcc cggtggtgag cggtgatacc agcccgcgtc acctgtccaa cgtcagcagc     6240

acgggcagca ttgatatggt ggatagcccg cagttggcta cgctggccga tgaggttagc     6300

gcgagcctgg cgaagcaggg tctgtgactc gagcaccacc accaccacca ctgagatccg     6360

gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta     6420

gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact     6480

atatccggat                                                            6490


<210>  46
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly 
                85                  90                  95      


Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro 
    130                 135                 140                 


Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
145                 150                 155                 160 


Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
                165                 170                 175     


Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
            180                 185                 190         


Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala 
        195                 200                 205             


Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
    210                 215                 220                 


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val 
225                 230                 235                 240 


Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu 
                245                 250                 255     


Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser 
            260                 265                 270         


Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu 
        275                 280                 285             


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr 
    290                 295                 300                 


His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly 
305                 310                 315                 320 


Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro 
                325                 330                 335     


Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp 
            340                 345                 350         


Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala 
        355                 360                 365             


Lys Gln Gly Leu 
    370         


<210>  47
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala 
1               5                   10                  15      


Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met 
            20                  25                  30          


His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu 
        35                  40                  45              


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
    50                  55                  60                  


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
65                  70                  75                  80  


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
                85                  90                  95      


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
            100                 105                 110         


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
        115                 120                 125             


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
    130                 135                 140                 


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
145                 150                 155                 160 


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
                165                 170                 175     


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
            180                 185                 190         


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
        195                 200                 205             


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro 
    210                 215                 220                 


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
225                 230                 235                 240 


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
                245                 250                 255     


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
            260                 265                 270         


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
        275                 280                 285             


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile 
    290                 295                 300                 


Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
305                 310                 315                 320 


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
                325                 330                 335     


Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly 
            340                 345                 350         


Leu 
    


<210>  48
<211>  6670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagatg tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

cgatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa     5160

ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat gggctcaagc     5220

caccaccacc accaccacag cagcggcgag aacttgtact ttcaaggatc cgcagaacca     5280

cgtcaagaat ttgaggttat ggaagatcac gcgggcactt acggtttggg tgatcgtaaa     5340

gaccagggcg gctataccat gcatcaagat caagagggcg acaccgatgc tggcttgaaa     5400

gagtcgccgc tgcagactcc gaccgaggat ggcagcgaag agccgggcag cgagactagc     5460

gatgcgaagt cgaccccgac cgccgaggca gaagaggcgg gtatcggcga cactccgtcc     5520

ctggaagatg aggcagccgg tcatgtcacg caggcgcgta tggtgagcaa gagcaaagat     5580

ggtacgggta gcgacgacaa gaaggcgaag ggcgcagatg gcaagaccaa aattgcgacg     5640

ccgcgtggtg cggcaccgcc aggccagaaa ggtcaggcga atgccacgcg catcccggca     5700

aagacgccac cggctccgaa aaccccgcct tccagcggtg aaccgccgaa atccggtgac     5760

cgcagcggtt atagctctcc gggtagcccg ggtaccccag gcagccgtag ccgcaccccg     5820

agcctgccga ccccaccgac ccgcgagccg aagaaagtgg cggtggttcg tacgccgcca     5880

aaaagcccga gctctgccaa gagccgtctg caaaccgctc ctgtgccgat gccggacctg     5940

aagaacgtta agtctaaaat cggtagcacc gaaaatctga agcaccaacc tggtggcggt     6000

aaggttcaaa tcatcaacaa aaagctggac ttgagcaatg tacaaagcaa gtgtggtagc     6060

aaggacaata tcaaacacgt cccgggtggt ggttccgtcc agattgtgta caaaccggtg     6120

gacctgagca aggttaccag caaatgcggt tccctgggta acatccatca taaaccgggt     6180

ggcggccaag ttgaggtcaa gagcgagaaa ctggacttca aagaccgcgt tcagtccaaa     6240

atcggttctc tggacaacat tacgcacgtg cctggtggtg gcaacaagaa gattgaaacc     6300

cataaactga cgtttcgtga aaatgcgaag gcgaaaaccg accacggcgc agagattgtc     6360

tacaaaagcc cggtggtgag cggtgatacc agcccgcgtc acctgtccaa cgtcagcagc     6420

acgggcagca ttgatatggt ggatagcccg cagttggcta cgctggccga tgaggttagc     6480

gcgagcctgg cgaagcaggg tctgtgactc gagcaccacc accaccacca ctgagatccg     6540

gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta     6600

gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact     6660

atatccggat                                                            6670


<210>  49
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu 
                85                  90                  95      


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
            100                 105                 110         


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
        115                 120                 125             


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
    130                 135                 140                 


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
145                 150                 155                 160 


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
                165                 170                 175     


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
            260                 265                 270         


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
    290                 295                 300                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
305                 310                 315                 320 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                325                 330                 335     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            340                 345                 350         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        355                 360                 365             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    370                 375                 380                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
385                 390                 395                 400 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                405                 410                 415     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430         


<210>  50
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala 
1               5                   10                  15      


Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met 
            20                  25                  30          


His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro 
        35                  40                  45              


Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr 
    50                  55                  60                  


Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile 
65                  70                  75                  80  


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
                85                  90                  95      


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
            100                 105                 110         


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
        115                 120                 125             


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
    130                 135                 140                 


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
145                 150                 155                 160 


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
                165                 170                 175     


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
            180                 185                 190         


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
        195                 200                 205             


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
    210                 215                 220                 


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
225                 230                 235                 240 


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
                245                 250                 255     


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
            260                 265                 270         


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
        275                 280                 285             


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
    290                 295                 300                 


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
305                 310                 315                 320 


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
                325                 330                 335     


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
            340                 345                 350         


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
        355                 360                 365             


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
    370                 375                 380                 


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
385                 390                 395                 400 


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410             


<210>  51
<211>  6016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
gctgcttcgc gatgtacggg ccagatatac gcgttttgag atttctgtcg ccgactaaat       60

tcatgtcgcg cgatagtggt gtttatcgcc gatagagatg gcgatattgg aaaaatcggc      120

ggccgccgat atttgaaaat atggcatatt gaaaatgtcg ccgatgtgag tttctgtgta      180

actgacatcg ccatttttcc aaaagtgatt tttgggcata cgcggtatct ggcgatagcg      240

cttatatcgt ttacggggga tggcgataga cgactttggt gacttgggcg attctgtgtg      300

tcgcaaatat cgcagtttcg atataggtga cagacgatat gaggctatat cgccgataga      360

ggcgacatca agctggcaca tggccaatgc atatcgatct atacattgaa tcaatattgg      420

ccattagcca tattattcat tggttatata gcataaatca atattggcta ttggccattg      480

catacgttgt atccatatca taatatgtac atttatattg gctcatgtcc aacattaccg      540

ccatgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt      600

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      660

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      720

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      780

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      840

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      900

tacgtattag tcatcgctat tacaatggtg atgcggtttt ggcagtacat caatgggcgt      960

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt     1020

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg     1080

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagaac tcgtttagtg     1140

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg     1200

gaccgatcca gcctccgcgg ccgggaacgg tgcattggaa cgcggattcc ccgtgccaag     1260

agtgacgtaa gtaccgccta tagagtctat aggcccaccc cattggcttc ttatgcatgc     1320

tatactgttt ttggcttggg gtctatacac ccccgcttcc tcatgttata ggtgatggta     1380

tagcttagcc tataggtgtg ggttattgac cattattgac cactccccta ttggtgacga     1440

tactttccat tactaatcca taacatggct ctttgccaca actctcttta ttggctatat     1500

gccaatacac tgtccttcag agactgacac ggactctgta tttttacagg atggggtctc     1560

atttattatt tacaaattca catatacaac accaccgtcc ccagtgcccg cagtttttat     1620

taaacataac gtgggatctc cacgcgaatc tagggtacgt gttacggaca tgggctattc     1680

tcaggtagcg gcggagcttc tacatccgag ccctgctccc atgcctccag cgaatcatgg     1740

tcgctcggca gctccttgct cctaacagtg gaggccagac ttaggcacag cacgatgccc     1800

accaccacca gtgtgccgca caaggccgtg gcggtagggt atgtgtctga aaatgaacta     1860

ggggagcggg cttgcaccgc tgacgcattt ggaagactta aggcagcggc agaagaagat     1920

gcaggcaact gagttgttgt gttctgataa gagtcagagg taactcccgt tgcggtgctg     1980

ttaacggtgg agggcagtgt agtctgagca gtactcgttg ctgccgcacg cgccaccaga     2040

cataatagct gacagactaa cagactgttc ctttcaatgg gtcttttatg cagtcaccgt     2100

ccttgacacg aagcttgcca ccatgggctc aagccaccat caccaccacc atcatcacca     2160

ccacagcagc ggcgagaact tgtactttca aggatccgct gagccccgcc aggagttcga     2220

agtgatggaa gatcacgctg ggacgtacgg gttgggggac aggaaagatc aggggggcta     2280

caccatgcac caagaccaag agggtgacac ggacgctggc ctgaaagaat ctcccctgca     2340

gacccccact gaggacggat ctgaggaacc gggctctgaa acctctgatg ctaagagcac     2400

tccaacagcg gaagatgtga cagcaccctt agtggatgag ggagctcccg gcaagcaggc     2460

tgccgcgcag ccccacacgg agatcccaga aggaaccaca gctgaagaag caggcattgg     2520

agacaccccc agcctggaag acgaagctgc tggtcacgtg acccaagctc gcatggtcag     2580

taaaagcaaa gacgggactg gaagcgatga caaaaaagcc aagggggctg atggtaaaac     2640

gaagatcgcc acaccgcggg gagcagcccc tccaggccag aagggccagg ccaacgccac     2700

caggattcca gcaaaaaccc cgcccgctcc aaagacacca cccagctctg gtgaacctcc     2760

aaaatcaggg gatcgcagcg gctacagcag ccccggctcc ccaggcactc ccggcagccg     2820

ctcccgcacc ccgtcccttc caaccccacc cacccgggag cccaagaagg tggcagtggt     2880

ccgtactcca cccaagtcgc cgtcttccgc caagagccgc ctgcagacag cccccgtgcc     2940

catgccagac ctgaagaatg tcaagtccaa gatcggctcc actgagaacc tgaagcacca     3000

gccgggaggc gggaaggtgc agataattaa taagaagctg gatcttagca acgtccagtc     3060

caagtgtggc tcaaaggata atatcaaaca cgtcccggga ggcggcagtg tgcaaatagt     3120

ctacaaacca gttgacctga gcaaggtgac ctccaagtgt ggctcattag gcaacatcca     3180

tcataaacca ggaggtggcc aggtggaagt aaaatctgag aagctagact tcaaggacag     3240

agtccagtcg aagattgggt ccctggacaa tatcacccac gtccctggcg gaggaaataa     3300

aaagattgaa acccacaagc tgaccttccg cgagaacgcc aaagccaaga cagaccacgg     3360

ggcggagatc gtgtacaagt cgccagtggt gtctggggac acgtctccac ggcatctcag     3420

caatgtctcc tccaccggca gcatcgacat ggtagactcg ccccagctcg ccacgctagc     3480

tgacgaggtg tctgcctccc tggccaagca gggtttgtga ctcgaggaga acttgtactt     3540

ccagggaagt ggtggcagtc atcaccatca ccatcaccat caccatcact gagaattcat     3600

tgatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac     3660

acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg     3720

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     3780

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgaa     3840

tcctctacgc cggacgcatc gtggccggca tcaccggcgc cacaggtgcg gttgctggcg     3900

cctatatcgc cgacatcacc gatggggaag atcgggctcg ccacttcggg ctcatgagcg     3960

cttgtttcgg cgtgggtatg gtggcaggcc ccgtggccgg gggactgttg ggcgccatct     4020

ccttgcatgc accattcctt gcggcggcgg tgctcaacgg cctcaaccta ctactgggct     4080

gcttcctaat gcaggagtcg cataagggag agcgtcgact ggggcgccct ctggtaaggt     4140

tgggaagccc tgcaaagtaa actggatggc tttctcgccg ccaagcatct gatggcgcag     4200

gggatcaagc tctgatcaag agacaggatg aggatcgttt cgcatgattg aacaagatgg     4260

attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca     4320

acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt     4380

tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaagacg aggcagcgcg     4440

gctatcgtgg ctggccacga cgggcgttcc ttgcgcagca gtgctcgacg ttgtcactga     4500

agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca     4560

ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct     4620

tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac     4680

tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc     4740

gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc gacggcgagg atctcgtcgt     4800

gacccacggc gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt     4860

catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg     4920

tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat     4980

cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgaat     5040

tattaacgct tacaatttcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc     5100

acaccgcatc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     5160

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     5220

aatagcacgt gctaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     5280

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     5340

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     5400

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     5460

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     5520

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     5580

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     5640

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     5700

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     5760

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     5820

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     5880

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     5940

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     6000

ttgctcacat gttctt                                                     6016


<210>  52
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Gly Glu Asn Leu Tyr Phe Gln Gly Ser Ala Glu Pro Arg Gln Glu Phe 
            20                  25                  30          


Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys 
        35                  40                  45              


Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp 
    50                  55                  60                  


Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser 
65                  70                  75                  80  


Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala 
                85                  90                  95      


Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln 
            100                 105                 110         


Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu 
        115                 120                 125             


Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly 
    130                 135                 140                 


His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly 
145                 150                 155                 160 


Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala 
                165                 170                 175     


Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala 
            180                 185                 190         


Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser 
        195                 200                 205             


Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
    210                 215                 220                 


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
225                 230                 235                 240 


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
                245                 250                 255     


Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val 
            260                 265                 270         


Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu 
        275                 280                 285             


Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys 
    290                 295                 300                 


Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn 
305                 310                 315                 320 


Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
                325                 330                 335     


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
            340                 345                 350         


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
        355                 360                 365             


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    370                 375                 380                 


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
385                 390                 395                 400 


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile 
                405                 410                 415     


Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
            420                 425                 430         


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
        435                 440                 445             


Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly 
    450                 455                 460                 


Leu 
465 


<210>  53
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53

Gly Ser Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala 
1               5                   10                  15      


Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met 
            20                  25                  30          


His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro 
        35                  40                  45              


Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr 
    50                  55                  60                  


Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu 
65                  70                  75                  80  


Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr 
                85                  90                  95      


Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr 
            100                 105                 110         


Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met 
        115                 120                 125             


Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys 
    130                 135                 140                 


Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro 
145                 150                 155                 160 


Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                165                 170                 175     


Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser 
            180                 185                 190         


Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly 
        195                 200                 205             


Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro 
    210                 215                 220                 


Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala 
225                 230                 235                 240 


Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
                245                 250                 255     


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
            260                 265                 270         


Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val 
        275                 280                 285             


Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly 
    290                 295                 300                 


Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
305                 310                 315                 320 


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
                325                 330                 335     


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
            340                 345                 350         


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
        355                 360                 365             


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
    370                 375                 380                 


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
385                 390                 395                 400 


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
                405                 410                 415     


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
            420                 425                 430         


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440         


<210>  54
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  54

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Ala Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  55
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  55

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Asp Ile Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Thr Asp Gly Ser Thr Asn Tyr Asn Thr Ala Val Gln 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Leu Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  56
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  56
gaggtgcagc tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

gccgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagtgcctcc      360

accaagggcc cctccgtgtt cccgctcgct ccatcatcga agtctaccag cggaggcact      420

gcggctctcg gttgcctcgt gaaggactac ttcccggagc cggtgaccgt gtcgtggaac      480

agcggagccc tgaccagcgg ggtgcacacc tttccggccg tcttgcagtc aagcggcctt      540

tactccctgt catcagtggt gactgtcccg tccagctcat tgggaaccca aacctacatc      600

tgcaatgtga atcacaaacc tagcaacacc aaggttgaca agaaagtcga gcccaaatcg      660

tgtgacaaga ctcacacttg tccgccgtgc ccggcacccg aactgctggg aggtcccagc      720

gtctttctgt tccctccaaa gccgaaagac acgctgatga tctcccgcac cccggaggtc      780

acttgcgtgg tcgtggacgt gtcacatgag gacccagagg tgaagttcaa ttggtacgtg      840

gatggcgtcg aagtccacaa tgccaaaact aagcccagag aagaacagta caattcgacc      900

taccgcgtcg tgtccgtgct cacggtgttg catcaggatt ggctgaacgg gaaggaatac      960

aagtgcaaag tgtccaacaa ggcgctgccg gcaccgatcg agaaaactat ctccaaagcg     1020

aagggacagc ctagggaacc tcaagtctac acgctgccac catcacggga tgaactgact     1080

aagaatcaag tctcactgac ttgtctggtg aaggggtttt accctagcga cattgccgtg     1140

gagtgggaat ccaacggcca gccagagaac aactacaaga ctacccctcc agtgctcgac     1200

tcggatggat cgttcttcct ttactcgaag ctcaccgtgg ataagtcccg gtggcagcag     1260

ggaaacgtgt tctcctgctc ggtgatgcat gaagccctcc ataaccacta tacccaaaag     1320

tcgctgtccc tgtcgccggg aaag                                            1344


<210>  57
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  57
gaggtgcaac tgcaggaatc cggtcccggc ctcgtgaagc cttcagaaac cctgtcgctc       60

acatgcactg tgtccgggtt ctccctgacc tctaacgaca tcgcctggat tcggcagccg      120

ccaggaaagg gactggagtg gatgggcacc atttggaccg acgggtcaac caactacaat      180

accgcggtgc aatccagagt gaccatcagc gtggacacgt ccaagaacca gttctcgctg      240

aaattgagct ccgtgactgc cgctgatact gccgtgtatt actgtgcccg gcaccgcctt      300

tactacggcg catttgacta ctggggacag ggaaccatgg tcactgtctc gagtgcctcc      360

accaagggcc cctccgtgtt cccgctcgct ccatcatcga agtctaccag cggaggcact      420

gcggctctcg gttgcctcgt gaaggactac ttcccggagc cggtgaccgt gtcgtggaac      480

agcggagccc tgaccagcgg ggtgcacacc tttccggccg tcttgcagtc aagcggcctt      540

tactccctgt catcagtggt gactgtcccg tccagctcat tgggaaccca aacctacatc      600

tgcaatgtga atcacaaacc tagcaacacc aaggttgaca agaaagtcga gcccaaatcg      660

tgtgacaaga ctcacacttg tccgccgtgc ccggcacccg aactgctggg aggtcccagc      720

gtctttctgt tccctccaaa gccgaaagac acgctgatga tctcccgcac cccggaggtc      780

acttgcgtgg tcgtggacgt gtcacatgag gacccagagg tgaagttcaa ttggtacgtg      840

gatggcgtcg aagtccacaa tgccaaaact aagcccagag aagaacagta caattcgacc      900

taccgcgtcg tgtccgtgct cacggtgttg catcaggatt ggctgaacgg gaaggaatac      960

aagtgcaaag tgtccaacaa ggcgctgccg gcaccgatcg agaaaactat ctccaaagcg     1020

aagggacagc ctagggaacc tcaagtctac acgctgccac catcacggga tgaactgact     1080

aagaatcaag tctcactgac ttgtctggtg aaggggtttt accctagcga cattgccgtg     1140

gagtgggaat ccaacggcca gccagagaac aactacaaga ctacccctcc agtgctcgac     1200

tcggatggat cgttcttcct ttactcgaag ctcaccgtgg ataagtcccg gtggcagcag     1260

ggaaacgtgt tctcctgctc ggtgatgcat gaagccctcc ataaccacta tacccaaaag     1320

tcgctgtccc tgtcgccggg aaag                                            1344


