                         SEQUENCE LISTING

<110>  bioMmune Technologies Inc.
       Fenninger, Franz
       Nohara, Lilian
       Jefferies, Wilfred
 
<120>  Methods of Treating Immune Disorders

<130>  BIMN-006/01WO 320528-2035

<150>  US 62/186,850
<151>  2015-06-30

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ala Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Glu 
465                 470                 475                 480 


Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val Cys Arg Arg Leu Arg 
            500                 505                 510         


Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Thr Gln Ile 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln 
    770                 775                 780                 


Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly 
785                 790                 795                 800 


Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu 
            820                 825                 830         


Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly 
        835                 840                 845             


Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg Lys Gly Cys 
    850                 855                 860                 


His Thr Leu Ile His His His Val Phe Thr Asn Leu Ile Leu Val Phe 
865                 870                 875                 880 


Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala 
                885                 890                 895     


His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr 
            900                 905                 910         


Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val Phe Gly Ala 
        915                 920                 925             


Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser 
945                 950                 955                 960 


Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Thr Cys Thr  Asp Glu Ala Lys His  Thr Pro Gln 
    1025                 1030                 1035             


Glu Cys  Lys Gly Ser Phe Leu  Val Tyr Pro Asp Gly  Asp Val Ser 
    1040                 1045                 1050             


Arg Pro  Leu Val Arg Glu Arg  Leu Trp Val Asn Ser  Asp Phe Asn 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1070                 1075                 1080             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala 
    1085                 1090                 1095             


Tyr Ala  Glu Asp His Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Val  Phe Phe Ile Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Ile Thr Phe  Arg Ala Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Pro His Gln  Tyr Arg Val Trp Ala  Thr Val Asn 
    1175                 1180                 1185             


Ser Ala  Ala Phe Glu Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Thr Val  Ala Leu Ala Met Gln  His Tyr Glu Gln Thr  Ala Pro Phe 
    1205                 1210                 1215             


Asn Tyr  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Leu Phe 
    1220                 1225                 1230             


Thr Ile  Glu Met Val Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Thr Asp Ala Trp Asn  Thr Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Val Thr Glu Val Asn  Asn Gly Gly 
    1265                 1270                 1275             


His Leu  Gly Glu Ser Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Thr 
    1280                 1285                 1290             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1295                 1300                 1305             


Lys Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1310                 1315                 1320             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe 
    1325                 1330                 1335             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1355                 1360                 1365             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1370                 1375                 1380             


Ala Trp  Gln Glu Ile Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys 
    1385                 1390                 1395             


Asp Pro  Glu Ser Asp Phe Gly  Pro Gly Glu Glu Phe  Thr Cys Gly 
    1400                 1405                 1410             


Ser Asn  Phe Ala Ile Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys 
    1415                 1420                 1425             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1430                 1435                 1440             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1445                 1450                 1455             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala 
    1460                 1465                 1470             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Ala Leu  Leu Arg Arg 
    1475                 1480                 1485             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1490                 1495                 1500             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1505                 1510                 1515             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1520                 1525                 1530             


Ser Leu  Lys Ile Lys Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Gln 
    1535                 1540                 1545             


Glu Leu  Arg Ile Val Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln 
    1550                 1555                 1560             


Lys Leu  Leu Asp Glu Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val 
    1565                 1570                 1575             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Asp Tyr Phe 
    1580                 1585                 1590             


Arg Lys  Phe Arg Arg Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp 
    1595                 1600                 1605             


Ala Ala  Pro Ser Thr Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser 
    1610                 1615                 1620             


Leu Gln  Asp Leu Gly Pro Glu  Met Arg Gln Ala Leu  Thr Cys Asp 
    1625                 1630                 1635             


Thr Glu  Glu Glu Glu Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu 
    1640                 1645                 1650             


Asp Glu  Lys Asp Leu Glu Thr  Asn Lys Ala Thr Met  Val Ser Gln 
    1655                 1660                 1665             


Pro Ser  Ala Arg Arg Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val 
    1670                 1675                 1680             


Gly Asp  Arg Leu Pro Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp 
    1685                 1690                 1695             


Asp Arg  Gly Thr Pro Thr Ser  Ser Gln Pro Ser Val  Pro Gln Ala 
    1700                 1705                 1710             


Gly Ser  Asn Thr His Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Thr 
    1715                 1720                 1725             


Ile Pro  Glu Glu Gly Asn Ser  Gln Pro Lys Gly Thr  Lys Gly Gln 
    1730                 1735                 1740             


Asn Lys  Gln Asp Glu Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr 
    1745                 1750                 1755             


Leu Asp  Glu Gln Ala Gly Thr  Pro Pro Cys Ser Val  Leu Leu Pro 
    1760                 1765                 1770             


Pro His  Arg Ala Gln Arg Tyr  Met Asp Gly His Leu  Val Pro Arg 
    1775                 1780                 1785             


Arg Arg  Leu Leu Pro Pro Thr  Pro Ala Gly Arg Lys  Pro Ser Phe 
    1790                 1795                 1800             


Thr Ile  Gln Cys Leu Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro 
    1805                 1810                 1815             


Ile Pro  Gly Thr Tyr His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg 
    1820                 1825                 1830             


Ala Gln  Gly Ser Trp Ala Thr  Pro Pro Gln Arg Gly  Arg Leu Leu 
    1835                 1840                 1845             


Tyr Ala  Pro Leu Leu Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly 
    1850                 1855                 1860             


Tyr Leu  Gly Arg Ser Ser Gly  Pro Leu Arg Thr Phe  Thr Cys Leu 
    1865                 1870                 1875             


His Val  Pro Gly Thr His Ser  Asp Pro Ser His Gly  Lys Arg Gly 
    1880                 1885                 1890             


Ser Ala  Asp Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    1895                 1900                 1905             


Gly Leu  Phe Ala Arg Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln 
    1910                 1915                 1920             


Glu Ile  Ala Asp Ala Cys Arg  Leu Thr Leu Asp Glu  Met Asp Asn 
    1925                 1930                 1935             


Ala Ala  Ser Asp Leu Leu Ala  Gln Gly Thr Ser Ser  Leu Tyr Ser 
    1940                 1945                 1950             


Asp Glu  Glu Ser Ile Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly 
    1955                 1960                 1965             


Asp Glu  Met Ala Cys Val His  Ala Leu 
    1970                 1975         


<210>  2
<211>  1984
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Glu Ser Glu Val Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Thr Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Thr Val Gly Thr Asp Thr Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Arg Arg Arg Thr Gln His Asn Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Thr Asn Pro 
65                  70                  75                  80  


Ile Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ser Cys Thr Leu Asn His Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Leu 
                405                 410                 415     


His Asp Pro Ser Val Asp Gly Asn Leu Ala Ser Leu Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ser Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Asp 
465                 470                 475                 480 


Thr Pro Gly Asp Glu Asp Glu Glu Glu Gly Thr Met Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Ile Cys Arg His Phe Arg 
            500                 505                 510         


Arg Ala Asn Arg Gly Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Leu Trp Leu Thr Gln Thr 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Val Tyr Val Ala Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Val 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Arg Glu Lys Ser Ser Glu Gly Asn Pro Pro Lys 
    770                 775                 780                 


Glu Asn Lys Val Leu Val Pro Gly Gly Glu Asn Glu Asp Ala Lys Gly 
785                 790                 795                 800 


Ala Arg Ser Glu Gly Ala Ala Pro Gly Met Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Gly Ala Gly His 
            820                 825                 830         


Val Glu Leu Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile 
        835                 840                 845             


Pro Glu Gly Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg 
    850                 855                 860                 


Lys Ala Cys His Thr Leu Ile His His His Ile Phe Thr Ser Leu Ile 
865                 870                 875                 880 


Leu Val Phe Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro 
                885                 890                 895     


Ile Arg Ala His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr 
            900                 905                 910         


Ala Phe Thr Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val 
        915                 920                 925             


Phe Gly Ala Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn 
    930                 935                 940                 


Leu Leu Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile 
945                 950                 955                 960 


His Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val 
                965                 970                 975     


Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val 
            980                 985                 990         


Val Gln Cys Val Phe Val Ala Ile  Arg Thr Ile Gly Asn  Ile Met Ile 
        995                 1000                 1005             


Val Thr  Thr Leu Leu Gln Phe  Met Phe Ala Cys Ile  Gly Val Gln 
    1010                 1015                 1020             


Leu Phe  Lys Gly Lys Phe Tyr  Ser Cys Thr Asp Glu  Ala Lys His 
    1025                 1030                 1035             


Thr Leu  Lys Glu Cys Lys Gly  Ser Phe Leu Ile Tyr  Pro Asp Gly 
    1040                 1045                 1050             


Asp Val  Ser Arg Pro Leu Val  Arg Glu Arg Leu Trp  Val Asn Ser 
    1055                 1060                 1065             


Asp Phe  Asn Phe Asp Asn Val  Leu Ser Ala Met Met  Ala Leu Phe 
    1070                 1075                 1080             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Ala Leu Leu  Tyr Lys Ala 
    1085                 1090                 1095             


Ile Asp  Ala Asn Ala Glu Asp  Glu Gly Pro Ile Tyr  Asn Tyr His 
    1100                 1105                 1110             


Val Glu  Ile Ser Val Phe Phe  Ile Val Tyr Ile Ile  Ile Ile Ala 
    1115                 1120                 1125             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Ile Thr Phe 
    1130                 1135                 1140             


Arg Ala  Gln Gly Glu Gln Glu  Tyr Gln Asn Cys Glu  Leu Asp Lys 
    1145                 1150                 1155             


Asn Gln  Arg Gln Cys Val Glu  Tyr Ala Leu Lys Ala  Gln Pro Leu 
    1160                 1165                 1170             


Arg Arg  Tyr Ile Pro Lys Asn  Pro His Gln Tyr Arg  Val Trp Ala 
    1175                 1180                 1185             


Thr Val  Asn Ser Ala Ala Phe  Glu Tyr Leu Met Phe  Leu Leu Ile 
    1190                 1195                 1200             


Leu Leu  Asn Thr Val Ala Leu  Ala Met Gln His Tyr  Glu Gln Thr 
    1205                 1210                 1215             


Ala Pro  Phe Asn Tyr Ala Met  Asp Ile Leu Asn Met  Val Phe Thr 
    1220                 1225                 1230             


Gly Leu  Phe Thr Ile Glu Met  Val Leu Lys Ile Ile  Ala Phe Lys 
    1235                 1240                 1245             


Pro Lys  His Tyr Phe Ala Asp  Ala Trp Asn Thr Phe  Asp Ala Leu 
    1250                 1255                 1260             


Ile Val  Val Gly Ser Val Val  Asp Ile Ala Val Thr  Glu Val Asn 
    1265                 1270                 1275             


Asn Gly  Gly His Leu Gly Glu  Ser Ser Glu Asp Ser  Ser Arg Ile 
    1280                 1285                 1290             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1295                 1300                 1305             


Leu Leu  Ser Lys Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1310                 1315                 1320             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala 
    1325                 1330                 1335             


Met Ile  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly 
    1340                 1345                 1350             


Lys Val  Ala Leu Gln Asp Gly  Thr Gln Ile Asn Arg  Asn Asn Asn 
    1355                 1360                 1365             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1370                 1375                 1380             


Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu Ala Ser  Leu Pro Gly 
    1385                 1390                 1395             


Asn Arg  Cys Asp Pro Glu Ser  Asp Phe Gly Pro Gly  Glu Glu Phe 
    1400                 1405                 1410             


Thr Cys  Gly Ser Ser Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Phe 
    1415                 1420                 1425             


Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile 
    1430                 1435                 1440             


Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly 
    1445                 1450                 1455             


Pro His  His Leu Asp Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp 
    1460                 1465                 1470             


Pro Gly  Ala Lys Gly Arg Ile  Lys His Leu Asp Val  Val Ala Leu 
    1475                 1480                 1485             


Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro 
    1490                 1495                 1500             


His Arg  Val Ala Cys Lys Arg  Leu Val Ala Met Asn  Val Pro Leu 
    1505                 1510                 1515             


Asn Ser  Asp Gly Thr Val Thr  Phe Asn Ala Thr Leu  Phe Ala Leu 
    1520                 1525                 1530             


Val Arg  Thr Ser Leu Lys Ile  Lys Thr Glu Gly Asn  Leu Asp Gln 
    1535                 1540                 1545             


Ala Asn  Gln Glu Leu Arg Met  Val Ile Lys Lys Ile  Trp Lys Arg 
    1550                 1555                 1560             


Ile Lys  Gln Lys Leu Leu Asp  Glu Val Ile Pro Pro  Pro Asp Glu 
    1565                 1570                 1575             


Glu Glu  Val Thr Val Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln 
    1580                 1585                 1590             


Asp Tyr  Phe Arg Lys Phe Arg  Arg Arg Lys Glu Lys  Gly Leu Leu 
    1595                 1600                 1605             


Gly Arg  Glu Ala Pro Thr Ser  Thr Ser Ser Ala Leu  Gln Ala Gly 
    1610                 1615                 1620             


Leu Arg  Ser Leu Gln Asp Leu  Gly Pro Glu Ile Arg  Gln Ala Leu 
    1625                 1630                 1635             


Thr Tyr  Asp Thr Glu Glu Glu  Glu Glu Glu Glu Glu  Ala Val Gly 
    1640                 1645                 1650             


Gln Glu  Ala Glu Glu Glu Glu  Ala Glu Asn Asn Pro  Glu Pro Tyr 
    1655                 1660                 1665             


Lys Asp  Ser Ile Asp Ser Gln  Pro Gln Ser Arg Trp  Asn Ser Arg 
    1670                 1675                 1680             


Ile Ser  Val Ser Leu Pro Val  Lys Glu Lys Leu Pro  Asp Ser Leu 
    1685                 1690                 1695             


Ser Thr  Gly Pro Ser Asp Asp  Asp Gly Leu Ala Pro  Asn Ser Arg 
    1700                 1705                 1710             


Gln Pro  Ser Val Ile Gln Ala  Gly Ser Gln Pro His  Arg Arg Ser 
    1715                 1720                 1725             


Ser Gly  Val Phe Met Phe Thr  Ile Pro Glu Glu Gly  Ser Ile Gln 
    1730                 1735                 1740             


Leu Lys  Gly Thr Gln Gly Gln  Asp Asn Gln Asn Glu  Glu Gln Glu 
    1745                 1750                 1755             


Val Pro  Asp Trp Thr Pro Asp  Leu Asp Glu Gln Ala  Gly Thr Pro 
    1760                 1765                 1770             


Ser Asn  Pro Val Leu Leu Pro  Pro His Trp Ser Gln  Gln His Val 
    1775                 1780                 1785             


Asn Gly  His His Val Pro Arg  Arg Arg Leu Leu Pro  Pro Thr Pro 
    1790                 1795                 1800             


Ala Gly  Arg Lys Pro Ser Phe  Thr Ile Gln Cys Leu  Gln Arg Gln 
    1805                 1810                 1815             


Gly Ser  Cys Glu Asp Leu Pro  Ile Pro Gly Thr Tyr  His Arg Gly 
    1820                 1825                 1830             


Arg Thr  Ser Gly Pro Ser Arg  Ala Gln Gly Ser Trp  Ala Ala Pro 
    1835                 1840                 1845             


Pro Gln  Lys Gly Arg Leu Leu  Tyr Ala Pro Leu Leu  Leu Val Glu 
    1850                 1855                 1860             


Glu Ser  Thr Val Gly Glu Gly  Tyr Leu Gly Lys Leu  Gly Gly Pro 
    1865                 1870                 1875             


Leu Arg  Thr Phe Thr Cys Leu  Gln Val Pro Gly Ala  His Pro Asn 
    1880                 1885                 1890             


Pro Ser  His Arg Lys Arg Gly  Ser Ala Asp Ser Leu  Val Glu Ala 
    1895                 1900                 1905             


Val Leu  Ile Ser Glu Gly Leu  Gly Leu Phe Ala Gln  Asp Pro Arg 
    1910                 1915                 1920             


Phe Val  Ala Leu Ala Lys Gln  Glu Ile Ala Asp Ala  Cys His Leu 
    1925                 1930                 1935             


Thr Leu  Asp Glu Met Asp Ser  Ala Ala Ser Asp Leu  Leu Ala Gln 
    1940                 1945                 1950             


Arg Thr  Thr Ser Leu Tyr Ser  Asp Glu Glu Ser Ile  Leu Ser Arg 
    1955                 1960                 1965             


Phe Asp  Glu Glu Asp Leu Gly  Asp Glu Met Ala Cys  Val His Ala 
    1970                 1975                 1980             


Leu 
    


<210>  3
<211>  6070
<212>  DNA
<213>  Homo sapiens

<400>  3
ctccaaagct gggggaagag aggggggttg tgtgcagatg gcccttcaat ctcgaaagaa       60

agatgtcgga atctgaaggc gggaaagaca ccaccccaga gcccagtcca gccaatgggg      120

caggccctgg tcccgaatgg gggctgtgcc ccgggccccc agctgtggaa ggtgaaagca      180

gtggggcatc aggcctaggg acccctaagc gaagaaacca gcacagcaag cacaagacag      240

tggcagtggc cagtgcccag cggtcacctc gggcactctt ctgcctcacc ctggccaatc      300

ctctgcgacg gtcctgcatc agcatcgtgg agtggaagcc cttcgacatc ctcatcctgc      360

tgaccatctt tgccaactgc gtggccctgg gagtttacat ccccttccct gaggacgact      420

ccaacactgc caaccacaac ctggagcagg tggagtacgt attcctggtg attttcactg      480

tggagacggt gctcaagatc gtggcctacg ggctggtgct ccaccccagc gcctacatcc      540

gcaatggctg gaacctactc gacttcatca tcgtcgtggt cgggctgttc agcgttctgc      600

tggagcaggg ccccggacgg ccaggcgacg ccccgcacac cgggggaaag ccaggaggct      660

tcgatgtgaa ggcattgagg gcgtttcggg tgctgcggcc actgaggctg gtgtctgggg      720

tcccgagcct gcacatagtg ctcaattcca tcatgaaggc tctggtgccg ctgctgcaca      780

ttgcactgct cgtgctcttc gtcatcatca tttatgccat cattgggctc gagctgttcc      840

ttggacgaat gcacaagacg tgctacttcc tgggatccga catggaagcg gaggaggacc      900

catcgccctg tgcgtcttcg ggatcagggc gtgcgtgcac gctgaaccag actgagtgcc      960

gcgggcgctg gccagggccc aatggaggca tcaccaactt tgacaacttc ttcttcgcca     1020

tgctgacagt cttccagtgt gtcaccatgg aaggctggac cgatgtgctc tactggatgc     1080

aagatgccat ggggtatgaa ctgccctggg tgtactttgt gagccttgtc atctttgggt     1140

ccttcttcgt cctcaacctt gtgcttggcg tcctgagtgg ggagttctcc aaggagagag     1200

agaaagcgaa agctcgcggg gacttccaga agcagcggga gaagcagcag atggaggaag     1260

acctgcgggg ctacctggac tggatcactc aagccgaaga gctggacatg gaggacccct     1320

ccgccgatga caaccttggt tctatggctg aagagggccg ggcgggccat cggccacagc     1380

tggccgagct gaccaatagg aggcgtggac gtctgcgctg gttcagtcat tctactcgct     1440

ccacacactc caccagcagc catgccagcc tcccagccag tgacaccggt tccatgacag     1500

agacccaagg cgatgaggat gaggaggagg gggctctggc cagctgtaca cgctgcctaa     1560

acaagatcat gaaaaccaga gtctgccgcc gcctccgccg agccaaccgg gtccttcggg     1620

cacgctgccg tcgggcagtg aagtccaatg cctgctactg ggctgtgctg ttgctcgtct     1680

tcctcaacac gttgaccatc gcctctgagc accacgggca gcctgtgtgg ctcacccaga     1740

tccaggagta tgccaacaaa gtgttgctct gtctgttcac ggtggagatg cttctcaaat     1800

tgtacggtct gggcccctct gcctatgtgt cttccttctt caaccgcttt gactgctttg     1860

tggtctgtgg gggcatccta gagaccacct tggtggaggt gggtgccatg cagcccttgg     1920

gcatctcagt gctccgatgt gtgcgcctcc tcaggatctt taaggtcacc agacactggg     1980

cttctctgag caatctggtg gcatccctgc tcaattcaat gaaatccatc gcatccttgc     2040

tgcttctcct cttcctcttc atcattatct tctccctgct tggcatgcag ctgtttgggg     2100

gcaagttcaa ctttgaccag acccacacca agcgaagcac ctttgacacg ttcccccagg     2160

ccctcctcac tgtctttcag atcctgacag gtgaggactg gaacgtggtc atgtatgatg     2220

gtatcatggc atatggtggc cccttcttcc caggaatgtt ggtgtgcatc tatttcatca     2280

ttctcttcat ctgtggcaac tacatcctgt tgaacgtgtt tcttgccatt gctgtggaca     2340

acctggccag tggagatgca ggcactgcca aggacaaggg cggggagaag agcaatgaga     2400

aggatctccc acaggagaat gaaggcctgg tgcctggtgt ggagaaagag gaagaggagg     2460

gtgcaaggag ggaaggagca gacatggagg aggaggagga ggaggaagaa gaggaagaag     2520

aggaagaaga ggaagagggt gcagggggtg tggaactcct gcaggaagtt gtacccaagg     2580

agaaggtggt acccatccct gagggcagcg ccttcttctg cctcagccaa accaacccgc     2640

tgaggaaggg ctgccacacc ctcatccacc atcatgtctt caccaatctt atcctggtgt     2700

tcatcatcct cagcagtgtg tccctggccg ctgaggaccc catccgagcc cactccttcc     2760

gcaaccatat tctgggttac ttcgattatg ccttcacctc cattttcact gtggagattc     2820

tactaaagat gacagtgttt ggggccttcc tgcaccgcgg ctccttctgc cgtagctggt     2880

ttaatatgtt ggatctgctg gtggtcagtg tgtccctcat ctcctttggc atccactcca     2940

gcgccatctc ggtggtgaag attctgcgag tactccgagt actgcggccc ctccgagcca     3000

tcaacagggc caagggactc aagcatgtgg tgcagtgtgt atttgtggcc atccggacca     3060

tcggaaacat catgattgtc accacacttc tgcaatttat gttcgcctgc atcggggtgc     3120

agctcttcaa ggggaaattc tacacctgca cggacgaggc caaacacacc cctcaagaat     3180

gcaagggctc cttcctggta tacccagatg gagacgtgtc acggcccctg gtccgggagc     3240

ggctctgggt caacagtgat ttcaactttg acaatgtcct ttcagccatg atggccctgt     3300

tcactgtctc cacctttgaa ggctggcctg cactgctata caaggccatc gatgcatatg     3360

cagaggacca cggccccatc tataattacc gtgtggagat ctcagtgttc ttcattgtct     3420

acatcatcat cattgcgttc ttcatgatga acatcttcgt gggcttcgtc atcatcactt     3480

tccgtgccca gggcgagcag gagtaccaaa actgtgagct ggacaagaac cagcgtcaat     3540

gtgtggaata tgccctcaag gcccagccac tccgccgtta catccccaag aacccgcatc     3600

agtatcgtgt gtgggccact gtgaactctg ctgcctttga gtacctgatg ttcctgctca     3660

tcctgctcaa cacagttgcc ctagccatgc agcactatga gcagactgct cccttcaact     3720

atgccatgga catcctcaac atggtcttca ctggcctctt cactattgag atggtgctca     3780

aaatcatcgc cttcaagccc aagcattact tcactgatgc ctggaacacg tttgacgctc     3840

ttattgtggt gggcagcata gtggatattg ccgtcactga agtcaataat ggtggccacc     3900

ttggcgagag ctctgaggac agctcccgca tttccattac cttctttcgc ctcttccgag     3960

ttatgcggct ggtcaagctt ctcagtaagg gtgaagggat ccgcacattg ctctggacat     4020

tcatcaagtc cttccaggcc ttgccctatg tggctcttct catcgcaatg atattcttca     4080

tctatgccgt cattggcatg cagatgttcg gcaaggtggc tcttcaggat ggcacacaga     4140

taaaccgaaa caacaacttc cagacctttc cacaggctgt gctgcttctg ttcaggtgtg     4200

ccactggtga ggcatggcag gagataatgc ttgccagcct tcccggaaat cggtgtgatc     4260

ctgagtctga cttcggccct ggtgaagagt ttacctgtgg tagcaatttt gccatcgcct     4320

atttcatcag cttcttcatg ctctgtgcct tcctgatcat aaatctcttt gtggctgtga     4380

tcatggacaa ctttgattat ctcaccagag attggtccat cctgggcccc catcaccttg     4440

atgaattcaa gaggatctgg tctgaatatg accctggggc caagggccgc atcaaacact     4500

tggatgtggt tgccctgctg agacgtatcc agccccctct gggatttggg aagctgtgcc     4560

cacaccgagt ggcctgcaag agacttgtgg caatgaacat gcccctcaac tcagatggga     4620

cggtgacatt caacgccaca ctctttgccc tggtccggac atccctgaag atcaaaacag     4680

aagggaacct ggagcaagcc aaccaggagc tgcggattgt catcaaaaag atctggaagc     4740

ggatgaaaca gaagctgcta gatgaggtca tccccccacc agacgaggag gaggtcaccg     4800

tgggcaaatt ctacgccaca tttctgatcc aggactattt ccgcaaattc cggcggagga     4860

aagaaaaagg gctactaggc aacgacgccg cccctagcac ctcttccgcc cttcaggctg     4920

gtctgcggag cctgcaggac ttgggtcctg agatgcggca ggccctcacc tgtgacacag     4980

aggaggagga agaagagggg caggagggag tggaggagga agatgaaaag gacttggaaa     5040

ctaacaaagc cacgatggtc tcccagccct cagctcgccg gggctccggg atttctgtgt     5100

ctctgcctgt cggggacaga cttccagatt cactctcctt tgggcccagt gatgatgaca     5160

gggggactcc cacctccagt cagcccagtg tgccccaggc tggatccaac acccacagga     5220

gaggctctgg ggctctcatt ttcaccatcc cagaagaagg aaattctcag cccaagggaa     5280

ccaaagggca aaacaagcaa gatgaggatg aggaagtccc tgatcggctt tcctacctag     5340

atgagcaggc agggactccc ccgtgctcag tccttttgcc acctcacaga gctcagagat     5400

acatggatgg gcacctggta ccacgccgcc gtctgctgcc ccccacacct gcaggtcgga     5460

agccctcctt caccatccag tgtctgcagc gccagggcag ttgtgaggat ttacccatcc     5520

caggcaccta tcatcgtggg cgaaattcag ggcccaatag ggctcagggt tcctgggcaa     5580

caccacctca gcggggtcgg ctcctgtatg ccccgctgtt gttggtggaa gagggcgcag     5640

cgggggaggg gtacctcggc agatccagtg gcccactgcg caccttcacc tgtctgcacg     5700

tgcctggaac ccactcggac cccagccatg ggaagagggg cagtgccgac agcttggtgg     5760

aggctgtgct tatctcagag ggtctgggcc tctttgctcg agacccacgt ttcgtggccc     5820

tggccaagca ggagattgca gatgcgtgtc gcctgacgct ggatgagatg gacaatgctg     5880

ccagtgacct gctggcacag ggaaccagct ctctctatag cgacgaggag tccatcctct     5940

cccgcttcga tgaggaggac ttgggagacg agatggcctg cgtccacgcc ctctgaattc     6000

ccacccctcc ccaactgctc aataaacctc ctgccctccc ctccccagca ggaggcaggc     6060

atggaccaca                                                            6070


<210>  4
<211>  6114
<212>  DNA
<213>  Mus musculus

<400>  4
tagttgggag gactgtgtgc atgatggtcc ttatatctcc tgaggaggat gtcggaatct       60

gaagtcggga aagatacaac cccagagccc agtccagcca atgggactgg ccctggccct      120

gaatgggggc tctgtcctgg gcctccaact gtggggactg ataccagcgg ggcgtcaggc      180

ctggggaccc caagaagaag gacccagcac aacaaacaca agactgtggc ggtggccagt      240

gctcagagat cacctcgagc gctcttctgc ctcaccctta ctaatcccat tcgtcggtcc      300

tgcatcagca ttgtagagtg gaagcctttt gatattctca tcctcctgac aatctttgcc      360

aactgcgtgg cattgggggt atatatcccc ttccctgagg acgactccaa cactgctaac      420

cacaacttgg aacaggtaga atacgtgttc ctggtgattt tcaccgtgga gacagtgctc      480

aagatcgtag cctatgggct ggtgctccat cccagcgcct atattcgcaa tggctggaac      540

ctgctcgact tcatcatcgt cgtggtcggg ctgttcagcg tgctgctgga acaaggacct      600

gggcggccag gagatgcccc gcatactgga ggaaagccag gaggcttcga tgtaaaggca      660

ctgcgggcat ttagggtgct acgacctcta aggctagtgt ctggggtccc gagtctgcac      720

atagtcgtca attccatcat gaaggcgctt gtgccgctgc tgcacattgc cctgttggtg      780

ctcttcgtca ttatcattta cgccatcatc ggactcgagc tattcctcgg acgaatgcac      840

aagacatgct acttcctggg atctgatatg gaagcagagg aggacccatc accttgtgca      900

tcttctggct ctgggcgttc atgcacactg aaccataccg agtgccgcgg gcgctggcca      960

ggacccaacg gtggcatcac gaacttcgac aattttttct ttgccatgct aactgtgttc     1020

cagtgtatta ccatggaagg ctggacagac gtcctctact ggatgcagga tgccatgggg     1080

tatgagctgc cttgggtgta ctttgtgagc cttgtcatct ttgggtcctt ctttgtcctc     1140

aaccttgtgc ttggagtcct aagcggggag ttctccaagg aaagagaaaa ggcaaaagca     1200

cgaggtgact ttcagaagct tcgggagaag cagcagatgg aagaagacct tcggggctac     1260

ctggactgga tcacacaggc tgaggagtta gaccttcatg acccctcagt agacggcaac     1320

ttggcttctc ttgctgaaga gggacgggcg ggccatcggc cacaactgtc agagctgacc     1380

aataggaggc gcggacggct gcgatggttc agccactcta ctcgctccac acactccacc     1440

agcagccacg ccagcctccc agccagtgac actggctcca tgacagacac ccctggagat     1500

gaggatgaag aagaggggac catggctagc tgtacacgct gcctaaacaa gattatgaaa     1560

acaaggatct gccgccactt ccgccgagcc aaccggggtc tccgtgcacg ctgccgccgg     1620

gccgtcaagt ccaacgcctg ctactgggct gtactgttgc tcgtcttcct caacacgttg     1680

accatcgctt cagagcacca tgggcagcct ttgtggctca cccagaccca agagtatgcc     1740

aacaaagttc tgctctgcct cttcactgtg gagatgctcc tcaaactgta cggcctgggc     1800

ccctctgtct acgttgcctc ctttttcaac cgctttgact gcttcgtggt ctgtgggggc     1860

atcctagaaa ccactttggt ggaggtgggg gccatgcagc ctcttggcat ctcagtgctc     1920

cgatgtgtac gtctcctcag gatcttcaag gtcaccaggc actgggcatc cctgagcaat     1980

ctggtggcat ctttgctcaa ttccatgaag tccatcgcct ccttgctgct tctcctcttt     2040

ctcttcatca tcatcttctc cctgcttggc atgcagctgt ttgggggcaa gttcaacttt     2100

gaccagaccc acaccaagag gagcaccttt gataccttcc cccaagccct cctcactgtc     2160

tttcagatcc tgactggtga ggattggaac gttgtcatgt atgatggtat catggcctac     2220

ggtgggccct tcttcccagg gatgctggtg tgtgtttatt tcatcatcct cttcatctgt     2280

ggcaactaca tcctgctgaa cgtgtttctt gccattgccg tggataacct agccagcggg     2340

gatgcaggca ctgccaaaga taagggcaga gagaagagca gtgaaggaaa ccctccaaag     2400

gagaacaaag tattggtgcc tggtggagag aatgaggacg caaagggcgc aagaagtgaa     2460

ggagcagcac caggcatgga ggaggaggag gaggaggagg aggaagaaga agaggaggag     2520

gaggaggaag aggaaaatgg tgcaggacat gtggaactct tgcaggaagt agtacccaag     2580

gagaaggtgg tacccatccc tgaaggcagt gccttcttct gccttagcca aaccaacccg     2640

cttcggaagg cctgccacac actcatacat caccatatct tcaccagtct catcctagtg     2700

ttcatcatcc tcagtagtgt gtccctggct gctgaggacc ccatccgagc tcactccttc     2760

cgaaaccata ttctgggata ttttgattat gccttcacct ccatattcac tgtggagatt     2820

ctactcaaga tgacagtgtt tggggccttc ctgcaccgag gctctttctg ccgtagctgg     2880

ttcaatctgt tggatctcct tgtggtcagt gtgtccctca tctccttcgg catccactcc     2940

agtgccatct cagttgtgaa gattctccga gtcctccgag tcctgcggcc tctccgagcc     3000

atcaacagag ccaagggact caagcatgtg gtgcagtgtg tgttcgtggc catccggacc     3060

atcggaaaca tcatgattgt caccaccctc ttgcagttca tgttcgcctg cattggtgtt     3120

cagctgttca agggaaaatt ctacagttgc actgatgagg ccaaacacac cctgaaagaa     3180

tcgaagggct ccttcctcat ctaccctgat ggagatgtgt cacgaccttt ggtccgggag     3240

cggctctggg tcaacagtga ttttaacttt gacaacgtcc tttcagccat gatggccctg     3300

ttcactgtct ctacctttga aggctggcct gcgctactat acaaggccat agatgcaaac     3360

gcagaagatg agggccctat ctacaattac catgtggaga tatcagtatt cttcattgtc     3420

tacatcatca tcatcgcctt cttcatgatg aacatctttg tgggctttgt tatcatcaca     3480

ttccgtgccc agggagagca ggagtaccaa aactgtgaac tggacaagaa ccagcgccag     3540

tgtgtggaat atgccctcaa agctcagcca ctccgccgat acatccctaa gaatcctcat     3600

cagtaccgcg tgtgggccac tgtgaactct cgtgcctttg agtacctcat gtttctgctc     3660

atcctgctca acacggtggc cctagccatg cagcactatg aacagactgc tccctttaac     3720

tatgccatgg acatcctcaa catggtcttc actggcctct tcaccattga gatggtgctc     3780

aaaatcatcg cctttaaacc caagcattac tttgcagatg cctggaatac gtttgatgct     3840

ctcattgtag tgggcagtgt agtcgacatc gccgtcacag aagtcaataa cggaggccat     3900

cttggcgaga gttcagagga cacgtcccgc atatctatca cgttctttcg cctcttccga     3960

gtcatgaggc tggtcaagct tctgagtaag ggtgaaggga tccgcacact gctctggaca     4020

ttcatcaagt ctttccaggc cttgccctat gtggcacttc tcatagcaat gatattcttc     4080

atctatgcag tcattggcat gcagatgttt ggcttggtgg ctcttcagga cggcacgcag     4140

ataaatcgaa acaacaattt ccagaccttt ccgcaggctg tgctgcttct gttcaggtgt     4200

gccactggtg aggcctggca agagataatg ctagccagcc ttccaggaaa tcgatgtgac     4260

cctgagtctg actttggccc aggcgaggaa tttacctgtg gtagcagttt tgccatcgtc     4320

tacttcatca gcttctttat gctctgtgcc ttcctgatta taaatctctt tgtggctgta     4380

atcatggata actttgatta cctaaccaga gattggtcta tcctgggacc ccaccacctt     4440

gatgaattca agaggatctg gtctgaatat gaccccggag ccaagggccg catcaagcac     4500

ttggatgtgg ttgccctgct gagacgcatc cagcccccat tgggatttgg aaagctatgc     4560

ccacaccgag tggcctgcaa gagactcgtg gcaatgaatg tgcccctcaa ctcagatgga     4620

acagtgacat tcaacgctac actctttgcc ctggtgcgga catccctgaa gatcaagaca     4680

gaagggaacc tggatcaagc caaccaggag cttcggatgg tcatcaaaaa gatctggaag     4740

cggataaagc agaaattgtt ggatgaggtc atccctcctc ccgatgagga ggaggtcact     4800

gtgggaaaat tctatgccac attcctgatc caagattatt tccgaaaatt ccggagaagg     4860

aaagaaaagg ggctactagg aagagaggcc ccaacaagca catcctctgc cctccaggct     4920

ggtctaagga gcctgcagga cttgggtcct gagatccgtc aagccctcac ctatgtcact     4980

gaggaagaag aggaagagga agaggcagtg ggtcaggagg ctgaggaaga ggaagctgag     5040

aacaacccag aaccatacaa agactccata gactcccagc cccaatctcg atggaactct     5100

aggatttcgg tgtctctacc tgttaaggag aaacttccag attctctctc aactgggccg     5160

agtgatgatg atgggctggc tcccaactcc aggcagccca gtgtgataca ggctggctcc     5220

caaccacaca ggagaagctc tggggttttc atgttcacta tcccggaaga aggaagtatt     5280

cagctcaagg gaactcaagg gcaggacaat cagaatgagg aacaggaact ccctgactgg     5340

actcctgacc tggatcgagc aggccgggac tccttcgaac ccagtccttt taccacctca     5400

ctggtccagc aacacgtaaa cgggcacatg tcgacgccga cgtttgctgc cccccacgcc     5460

tgcaggtcgg agccctcctt caccatccag tgtctgcaac gcctgggcag ttgtgaagat     5520

ttacctatcc caggcaccta ccatcgtgga cggacctcag gaccaagcag ggctcagggt     5580

tcctgggcag cccctcctca gaagggtcga ctgctatatg cccccctgtt gttggtggag     5640

gaatctacag tgggtgaagg ataccttggc aaacttggcg gcccactgcg taccttcacc     5700

tgtctgcaag tgcctggagc tcatccgaat cccagccacc gcaagagggg cagtgctgac     5760

agtttggtgg aggctgtgct catctccgaa ggcctaggtc tctttgccca agacccacga     5820

tttgtggccc tggccaagca ggagattgca gatgcatgtc acctgaccct ggatgagatg     5880

gacagtgctg ccagtgacct gctggcacag agaaccatct ccctttacag tgatgaggag     5940

tctattcttt cccgctttga tgaagaggac ctgggagatg agatggcctg tgtccatgcc     6000

ctctaaatcc ttacccctca tctactgctc aataaactcc ctgcccttcc ttcccccaga     6060

ggaggcaggc atggaccaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           6114


