                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
       Yin, Hao
       Anderson, Daniel G.
 
<120>  COMPOSITIONS COMPRISING NUCLEIC ACIDS

<130>  127299.00302

<140>  PCT/US2016/040221
<141>  2016-06-29

<150>  62/186,358
<151>  2015-06-29

<150>  62/243,589
<151>  2015-10-19

<150>  62/290,907
<151>  2016-02-03

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA1 GFP-1

<400>  1
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  2
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 GFP-2


<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (70)..(72)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (85)..(86)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (96)..(101)
<223>  fluorinated base

<400>  2
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  3
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA3 GFP-3


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  fluorinated base

<400>  3
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  4
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2F GPF-4


<220>
<221>  misc_feature
<222>  (22)..(25)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (59)..(61)
<223>  fluorinated base

<400>  4
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  5
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2F GFP-5


<220>
<221>  misc_feature
<222>  (22)..(25)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (59)..(61)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (70)..(72)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (85)..(86)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (96)..(101)
<223>  fluorinated base

<400>  5
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  6
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2F GFP-6


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  fluorinated base

<400>  6
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  7
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2F GFP-7


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (22)..(25)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (59)..(61)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (70)..(72)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (85)..(86)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (96)..(101)
<223>  fluorinated base

<400>  7
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  8
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2F GFP-8


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (85)..(86)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (96)..(101)
<223>  fluorinated base

<400>  8
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  9
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  u and c GFP-9


<220>
<221>  misc_feature
<222>  (62)..(66)
<223>  methylated base

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  methylated base

<220>
<221>  misc_feature
<222>  (74)..(76)
<223>  methylated base

<220>
<221>  misc_feature
<222>  (78)..(81)
<223>  methylated base

<400>  9
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  10
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  u and c GFP-10


<220>
<221>  misc_feature
<222>  (29)..(32)
<223>  methylated base

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  methylated base

<400>  10
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  11
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA11

<400>  11
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg                          42


<210>  12
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA12

<400>  12
uuaucaacuu gaaaaagugg caccgagucg gugcuuuuuu u                           41


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA13

<400>  13
gggcgaggag cuguucaccg                                                   20


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-abl IV

<400>  14

Asp Arg Leu Arg Arg 
1               5   


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NS1 15

<400>  15

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hepatitis virus delta antigen16

<400>  16

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mx protein17

<400>  17

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADP-ribose18

<400>  18

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucocorticoid19

<400>  19

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 20


<220>
<221>  misc_feature
<222>  (9)..(21)
<223>  n is a, c, g, or t

<400>  20
mmmmmmmmnn nnnnnnnnnn ngg                                               23


<210>  21
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 21


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<400>  21
nnnnnnnnnn nnngg                                                        15


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. pyogenes Cas9 22


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  n is a, c, g, or t

<400>  22
mmmmmmmmmn nnnnnnnnnn ngg                                               23


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 23


<220>
<221>  misc_feature
<222>  (9)..(22)
<223>  n is a, c, g, or t

<400>  23
mmmmmmmmnn nnnnnnnnnn nnagaaw                                           27


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 24


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  n is a, c, g, or t

<400>  24
nnnnnnnnnn nnnnagaaw                                                    19


<210>  25
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. thermophilus CRISPR1 Cas9 25


<220>
<221>  misc_feature
<222>  (10)..(22)
<223>  n is a, c, g, or t

<400>  25
mmmmmmmmmn nnnnnnnnnn nnagaaw                                           27


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. thermophilus CRISPR1 Cas9 26


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<400>  26
nnnnnnnnnn nnnagaaw                                                     18


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 27


<220>
<221>  misc_feature
<222>  (9)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a, c, g, or t

<400>  27
mmmmmmmmnn nnnnnnnnnn nggng                                             25


<210>  28
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 28


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  28
nnnnnnnnnn nnnggng                                                      17


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. pyogenes Cas9 29


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a, c, g, or t

<400>  29
mmmmmmmmmn nnnnnnnnnn nggng                                             25


<210>  30
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S. pyogenes Cas9 30


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  30
nnnnnnnnnn nnggng                                                       16


<210>  31
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-1 31

<400>  31
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  32
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA 32

<400>  32
aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa guggcaccga       60

gucggugcuu uuuuu                                                        75


<210>  33
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-3 33


<220>
<221>  misc_feature
<222>  (20)..(42)
<223>  deoxyribonucleic acid

<400>  33
gggcgaggag ctgttcaccg guuuuagagc uaugcuguuu ug                          42


<210>  34
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-4 34


<220>
<221>  misc_feature
<222>  (10)..(42)
<223>  deoxyribonucleic

<400>  34
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-7 35


<220>
<221>  misc_feature
<222>  (18)..(42)
<223>  deoxyribonucleic

<400>  35
gggcgaggag ctgttcaccg guuuuagagc uaugcuguuu ug                          42


<210>  36
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-8 36


<220>
<221>  misc_feature
<222>  (16)..(42)
<223>  deoxyribonucleic

<400>  36
gggcgaggag ctgttcaccg guuuuagarg cuaugcuguu uug                         43


<210>  37
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-9 37


<220>
<221>  misc_feature
<222>  (14)..(42)
<223>  deoxyribonucleic

<400>  37
gggcgaggag ctgtucaccg guuuuagagc uaugcuguuu ug                          42


<210>  38
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-10 38


<220>
<221>  misc_feature
<222>  (12)..(42)
<223>  deoxyribonucleic

<400>  38
gggcgaggag ctguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  39
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-11 39


<220>
<221>  misc_feature
<222>  (8)..(42)
<223>  deoxyribonucleic

<400>  39
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  40
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-12 40


<220>
<221>  misc_feature
<222>  (6)..(42)
<223>  deoxyribonucleic

<400>  40
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  41
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-13 41


<220>
<221>  misc_feature
<222>  (4)..(42)
<223>  deoxyribonucleic

<400>  41
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  42
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA-GFP-14 42


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  deoxyribonucleic

<400>  42
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  43
<211>  101
<212>  RNA
<213>  Artificial  Sequence

<220>
<223>  2F GFP-12 43


<220>
<221>  misc_feature
<222>  (30)..(32)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (69)..(80)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (85)..(86)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (96)..(101)
<223>  fluorinated base

<400>  43
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  44
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-33 44


<220>
<221>  misc_feature
<222>  (21)..(101)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (21)..(101)
<223>  phosphorothioate modified pentose sugar

<400>  44
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  45
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GFP sgRNA45

<400>  45
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  46
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-35 46


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  0-methylated base

<400>  46
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  47
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-36 47


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (29)..(33)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  0-methylated base

<400>  47
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  48
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-39 48


<220>
<221>  misc_feature
<222>  (70)..(79)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (70)..(79)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (84)..(90)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (92)..(101)
<223>  phosphorothioate

<400>  48
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  49
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-40 49


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  Phosphorothioate

<220>
<221>  misc_feature
<222>  (29)..(32)
<223>  Phosphorothioate

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Phosphorothioate

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Phosphorothioate

<400>  49
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  50
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-CS 50


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  0-methylated base

<400>  50
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  51
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-17 51


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  0-methylated base

<400>  51
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  52
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-18 52


<220>
<221>  misc_feature
<223>  0-methylated base

<400>  52
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  53
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-19 53


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  0-methylated base

<400>  53
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  54
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-20 54


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  0-methylated base

<400>  54
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  55
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-21 55


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  0-methylated base

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  0-methylated base

<400>  55
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  56
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  nf GFP-22 56


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  fluorinated base

<400>  56
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  57
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  nf GFP-23 57


<220>
<221>  misc_feature
<222>  (11)..(20)
<223>  fluorinated base

<400>  57
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  58
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  nf GFP-24 58


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  fluorinated base

<400>  58
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  59
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  nf GFP-25 59


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  fluorinated base

<400>  59
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  60
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  nf GFP-26 60


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  fluorinated base

<400>  60
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  61
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-27 61


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  phosphorothioate modified pentose sugar

<400>  61
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  62
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-28 62


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  Phosphorothioate modified pentose sugar

<400>  62
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  63
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-29 63


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Phosphorothioate modified pentose sugar

<400>  63
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  64
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  n GFP-30 64

<400>  64
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  65
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-31 65


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  phosphorothioate modified pentose sugar

<400>  65
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  66
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  s GFP-32 66


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  66
gggcgaggag cuguucaccg guuuuagagc uaugcuguuu ug                          42


<210>  67
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-VEGFA 67

<400>  67
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  68
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-VEGFA_M 68


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate modified pentose sugar

<400>  68
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  69
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMX1 69

<400>  69
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  70
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMX1_M 70


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  70
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  71
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-HBB 71

<400>  71
cuugccccac agggcaguaa guuuuagagc uaugcuguuu ug                          42


<210>  72
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-HBB_M 72


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  72
cuugccccac agggcaguaa guuuuagagc uaugcuguuu ug                          42


<210>  73
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GFP-42 73


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  phosphorothioate modified pentose sugar

<400>  73
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  74
<211>  101
<212>  RNA
<213>  Artificial Sequenc

<220>
<223>  s GFP- 43 74


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (29)..(32)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  phosphorothioate modified pentose sugar

<400>  74
gggcgaggag cuguucaccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu u                          101


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 75

<400>  75

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 76

<400>  76

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc NLS 77

<400>  77

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc NLS 78

<400>  78

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  79
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNPAI M9 NLS 79

<400>  79

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  80
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNPAI M9 NLS 80

<400>  80

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  importin-alpha 81

<400>  81

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSRKRPRP 82

<400>  82

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myoma T protein 83

<400>  83

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human p53 84

<400>  84

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse sgRNA-1 85

<400>  85
gcacccatac cttggagcaa                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 86

<400>  86
cccatacctt ggagcaacgg                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 87

<400>  87
gctcgccctc ccgtcccagg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 88

<400>  88
gttggtcccc aaagtcccca                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 89

<400>  89
gctccggcag cagatggcaa                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 90

<400>  90
tctttgactc taaggcccaa                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 91

<400>  91
catgtggcct ggtcaacaag                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 92

<400>  92
tgtgctggct tccatgaagg                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 93

<400>  93
tagatcgaag acatgtggct                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 94

<400>  94
tgaaaacaag agcaaggccg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 95

<400>  95
gcgccgtagc ctcagcctga                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 96

<400>  96
ggcgcatgtg aactccctgg                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-1 97

<400>  97
ggtcagctac tgggacaccg                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 98

<400>  98
agtgatgttg aggaagagga                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 99

<400>  99
gagcttcctg aattaaactt                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 100

<400>  100
catagacccc tgttgtaaga                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 101

<400>  101
aggaagtcag aatctgggca                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 102

<400>  102
tggcttgcct tggatttcag                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 103

<400>  103
ggtaggggaa gaccaccgag                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 104

<400>  104
gtatttctac tgcgacgagg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 105

<400>  105
cttcggggag acaacgacgg                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 106

<400>  106
tcccttctca ggattcctac                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 107

<400>  107
agatattcac cattataggt                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 108

<400>  108
aattactact tgcttcctgt                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sgRNA-1 109

<400>  109
ggtcggtctc cgagtccccg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2 110

<400>  110
gatgatgtac ctctgccagc                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 111

<400>  111
tcagatcgtg cacgtccgcg                                                   20


<210>  112
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas-protein 112

<400>  112
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg                          42


<210>  113
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas-protein 113


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (5)..(22)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (28)..(30)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (32)..(37)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (39)..(41)
<223>  n is a, c, g, t or u

<400>  113
nuuunnnnnn nnnnnnnnnn nnguunannn annnnnngnn ng                          42


<210>  114
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid 114

<400>  114
uuaucaacuu gaaaaagugg caccgagucg gugcuuuuu                              39


<210>  115
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid 115


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (7)..(39)
<223>  n is a, c, g, t or u

<400>  115
uuannannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnn                              39


<210>  116
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HY-VTM3 116


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  116
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  117
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HY-VTM4 117


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  117
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  118
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HY-VTM6 118


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  118
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  119
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMXM3 119


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  119
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  120
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMXM4 120


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  fluorinated base

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  fluorinated base

<400>  120
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  121
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMXM5 121


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (3)..(8)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate modified pentose sugar

<400>  121
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  122
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-EMXM6 122


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate modified pentose sugar

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate modified pentose sugar

<400>  122
gaguccgagc agaagaagaa guuuuagagc uaugcuguuu ug                          42


<210>  123
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HBBM3 crRNA

<400>  123
cuugccccac agggcaguaa guuuuagagc uaugcuguuu ug                          42


<210>  124
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-HBBM4

<400>  124
cuugccccac agggcaguaa guuuuagagc uaugcuguuu ug                          42


<210>  125
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-HBBM5


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioated deoxyribonucleoside

<400>  125
cuugccccac agggcaguaa guuuuagagc uaugcuguuu ug                          42


<210>  126
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PC-9 cRNA

<400>  126
ggcugaugag gccgcacaug guuuuagagc uaugcuguuu ug                          42


<210>  127
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-PC9M1


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioated ribnucleoside

<400>  127
ggcugaugag gccgcacaug guuuuagagc uaugcuguuu ug                          42


<210>  128
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HY-PC9M2


<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  fluorinated nucleotide

<400>  128
ggcugaugag gccgcacaug guuuuagagc uaugcuguuu ug                          42


<210>  129
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgHBB1

<400>  129
cuugccccac agggcaguaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  130
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgHBB2


<220>
<221>  misc_feature
<222>  (82)..(100)
<223>  deoxyribonucleic nucleoside

<400>  130
cuugccccac agggcaguaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  131
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgHBB3


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methylation

<400>  131
cuugccccac agggcaguaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  132
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HBB4


<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  phosphorothioate modified nucleoside

<400>  132
cuugccccac agggcaguaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  133
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgHBB5


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  fluorinated nucleoside

<400>  133
cuugccccac agggcaguaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  134
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HYVT1


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  deoxyribonucleotsides with RNA base

<400>  134
gacccccucc accccgccuc guuuuagagc uaugcuguuu ug                          42


<210>  135
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HYVT2


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  deoxyribonucleic acids

<220>
<221>  misc_feature
<222>  (11)..(42)
<223>  ribonucleic bases

<400>  135
gaccccctcc accccgccuc guuuuagagc uaugcuguuu ug                          42


