                         SEQUENCE LISTING

<110>  SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
       WARE, Carl F.
       SEDY, John
 
<120>  BTLA FUSION PROTEIN AGONISTS AND USES THEREOF

<130>  BURN1680-1WO

<150>  US 62/187,105
<151>  2015-06-30

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  1049
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  HVEM

<400>  1
gccgcagcaa tggcgctgag ttcctctgct ggagttcatc ctgctagctg ggttcccgag       60

ctgccggtct gagcctgagg catggagcct cctggagact gggggcctcc tccctggaga      120

tccaccccca gaaccgacgt cttgaggctg gtgctgtatc tcaccttcct gggagccccc      180

tgctacgccc cagctctgcc gtcctgcaag gaggacgagt acccagtggg ctccgagtgc      240

tgccccaagt gcagtccagg ttatcgtgtg aaggaggcct gcggggagct gacgggcaca      300

gtgtgtgaac cctgccctcc aggcacctac attgcccacc tcaatggcct aagcaagtgt      360

ctgcagtgcc aaatgtgtga cccagccatg ggcctgcgcg cgagccggaa ctgctccagg      420

acagagaacg ccgtgtgtgg ctgcagccca ggccacttct gcatcgtcca ggacggggac      480

cactgcgccg cgtgccgcgc ttacgccacc tccagcccgg gccagagggt gcagaaggga      540

ggcaccgaga gtcaggacac cctgtgtcag aactgccccc cggggacctt ctctcccaat      600

gggaccctgg aggaatgtca gcaccagacc aagtgcagct ggctggtgac gaaggccgga      660

gctgggacca gcagctccca ctgggtatgg tggtttctct cagggagcct cgtcatcgtc      720

attgtttgct ccacagttgg cctaatcata tgtgtgaaaa gaagaaagcc aaggggtgat      780

gtagtcaagg tgatcgtctc cgtccagcgg aaaagacagg aggcagaagg tgaggccaca      840

gtcattgagg ccctgcaggc ccctccggac gtcaccacgg tggccgtgga ggagacaata      900

ccctcattca cggggaggag cccaaaccac tgacccacag actctgcacc ccgacgccag      960

agatacctgg agcgacggct gctgaaagag gctgtccacc tggcgaaacc accggagccc     1020

ggaggcttgg gggctccgcc ctgggctgg                                       1049


<210>  2
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Arg Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  3
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  3
aaacccgaag cagtgcaatt aggaaatcag tg                                     32


<210>  4
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  4
taattgcact gcttcgggtt tgcatatttc ag                                     32


<210>  5
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  5
acccgaagaa tatcaattag gaaatcagtg ttgtc                                  35


<210>  6
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  6
ttcctaattg atattcttcg ggtttgcata tttc                                   34


<210>  7
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  7
gaagaagtgc cattaggaaa tcagtgttgt ccc                                    33


<210>  8
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  8
atttcctaat ggcacttctt cgggtttgca tatttc                                 36


<210>  9
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  9
gcaattagga agtcagtgtt gtcccccatg taaac                                  35


<210>  10
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  10
acaacactga cttcctaatt gcacttcttc gg                                     32


<210>  11
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  11
ttaggaaatg cgtgttgtcc cccatgtaaa caag                                   34


<210>  12
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  12
gggacaacac gcatttccta attgcacttc ttc                                    33


<210>  13
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  13
cagtgttgtg ccccatgtaa acaaggatat cgtg                                   34


<210>  14
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  14
tttacatggg gcacaacact gatttcctaa ttg                                    33


<210>  15
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  15
gtgttgtccc aaatgtaaac aaggatatcg tgttac                                 36


<210>  16
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  16
ttgtttacat ttgggacaac actgatttcc taattg                                 36


<210>  17
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  17
tcccccatgt tcacaaggat atcgtgttac agg                                    33


<210>  18
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  18
atatccttgt gaacatgggg gacaacactg atttc                                  35


<210>  19
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  19
tgtaaacaag catatcgtgt tacaggacaa tgtac                                  35


<210>  20
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  20
aacacgatat gcttgtttac atgggggaca acactg                                 36


<210>  21
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  21
cccccatgta aacaaggagc tcgtgttaca ggacaatg                               38


<210>  22
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  22
cattgtcctg taacacgagc tccttgttta catggggg                               38


<210>  23
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  23
caaggatatg ctgttacagg acaatgtacg caatatac                               38


<210>  24
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  24
tcctgtaaca gcatatcctt gtttacatgg ggg                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  25
tatcgtgttg caggacaatg tacgcaatat acg                                    33


<210>  26
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  26
acattgtcct gcaacacgat atccttgttt acatgg                                 36


<210>  27
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  27
cgtgttacag cacaatgtac gcaatatacg agtac                                  35


<210>  28
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  28
cgtacattgt gctgtaacac gatatccttg tttac                                  35


<210>  29
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  29
aaacaaggat atcgtgttac aaaacaatgt acgcaatata cgagt                       45


<210>  30
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  30
actcgtatat tgcgtacatt gttttgtaac acgatatcct tgttt                       45


<210>  31
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  31
gttacaggag catgtacgca atatacgagt acaac                                  35


<210>  32
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  32
tgcgtacatg ctcctgtaac acgatatcct tg                                     32


<210>  33
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  33
ggacaatgtg ggcaatatac gagtacaaca tgtac                                  35


<210>  34
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  34
cgtatattgc ccacattgtc ctgtaacacg atatc                                  35


<210>  35
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  35
caatgtacgg catatacgag tacaacatgt acag                                   34


<210>  36
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  36
actcgtatat gccgtacatt gtcctgtaac acgatatc                               38


<210>  37
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  37
acgcaatatg cgagtacaac atgtacactt tgccc                                  35


<210>  38
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  38
tgttgtactc gcatattgcg tacattgttc tgtaac                                 36


<210>  39
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  39
tgttgtactc gcatattgcg tacattgttc tgtaac                                 36


<210>  40
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  40
cgtaccggca gggcaaagtg tacatgttgt ac                                     32


<210>  41
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  41
gtatcagggg cttacaattg taccaattgc actg                                   34


<210>  42
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  42
acaattgtaa gcccctgata catacgtacc gttag                                  35


<210>  43
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  43
caattgcact atgtgtaatg acactgaggt tac                                    33


<210>  44
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  44
caattgcact atgtgtaatg acactgaggt tac                                    33


<210>  45
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  45
ttttccgttg caggcgtcca acatcacaag caacg                                  35


<210>  46
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  46
ttggacgcct gcaacggaaa atgacgtata attc                                   34


<210>  47
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  47
caagtgcagt tcaggttatc gtgtgaagga g                                      31


<210>  48
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  48
cgataacctg aactgcactt ggggcagcac                                        30


<210>  49
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  49
tgcagtccag attatcgtgt gaaggaggcc tg                                     32


<210>  50
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  50
acacgataat ctggactgca cttggggc                                          28


<210>  51
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  51
gtccaggttg tcgtgtgaag gaggcctgc                                         29


<210>  52
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  52
cttcacacga caacctggac tgcacttggg                                        30


<210>  53
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  53
gctgacggac acagtgtgtg aaccctgc                                          28


<210>  54
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  54
acacactgtg tccgtcagct ccccgcag                                          28


<210>  55
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  55
tccaggcccc tacattgccc acctcaatg                                         29


<210>  56
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  56
aatgtagggg cctggagggc agggttc                                           27


<210>  57
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  57
ctcaatggcc taataagcaa gtgtctgcag tgc                                    33


<210>  58
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  58
cacttgctta ttaggccatt gaggtgggca atg                                    33


<210>  59
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  59
gtgacccacc catgggcctg cgcgcg                                            26


<210>  60
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  60
ggcccatggg tgggtcacac atttggcact g                                      31


<210>  61
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  61
cgcgagctgg aactgctcca ggacagag                                          28


<210>  62
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  62
gagcagttcc agctcgcgcg caggccc                                           27


<210>  63
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  63
catgtgatgt agcgctttat ataaagagac aatctgaaca ctc                         43


<210>  64
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  64
ctttatataa agcgctacat cacatgattc tttcccatg                              39


<210>  65
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  65
atgtgatgta cagcattata taaagagaca atctgaacac tcc                         43


<210>  66
<211>  41
<212>  DNA
<213>  Homo sapiens

<400>  66
ttgtctcttt atataatgct gtacatcaca tgattctttc c                           41


<210>  67
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  67
ctttatataa aggaccaatc tgaacactcc atcttagc                               38


<210>  68
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  68
gtgttcagat tggtccttta tataaagctg tacatcacat gattc                       45


<210>  69
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  69
agagacaatc tgcacactcc atcttagcag gagatcc                                37


<210>  70
<211>  41
<212>  DNA
<213>  Homo sapiens

<400>  70
aagatggagt gtggagattg tctctttata taaagctgta c                           41


<210>  71
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  71
ctttgaacta gcatgccctg tgaaatactg tgctaac                                37


<210>  72
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  72
tcacagggca tgctagttca aagggatctc ctgctaag                               38


<210>  73
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  73
gaactagaat gcgctgtgaa atactgtgct aacaggc                                37


<210>  74
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  74
gtatttcaca gcgcattcta gttcaaaggg atctc                                  35


<210>  75
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  75
acaagttggg cggaagagaa gaacatttca tttttcattc                             40


<210>  76
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  76
cttctcttcc gcccaacttg tttgtctatc ttcaagtttt ac                          42


<210>  77
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  77
tgttctgcaa attttcagtc taatctcatt gaaagc                                 36


<210>  78
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  78
gattagactg aaaatttgca gaacagcggt atgaccc                                37


<210>  79
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  79
gctgttctgc attttttcag tctaatctca ttgaaagc                               38


<210>  80
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  80
tagactgaaa aaatgcagaa cagcggtatg ac                                     32


<210>  81
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  81
gttctgcaaa tgctcagtct aatctcattg aaagccac                               38


<210>  82
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  82
gagattagac tgagcatttg cagaacagcg gtatg                                  35


<210>  83
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  83
caaattttca gcataatctc attgaaagcc actcaac                                37


<210>  84
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  84
caatgagatt atgctgaaaa tttgcagaac agcg                                   34


<210>  85
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  85
cattgaaagc gactcaacaa ctctttatgt gacagatg                               38


<210>  86
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  86
gttgttgagt cgctttcaat gagattagac tgaaaatttg                             40


<210>  87
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  87
tgaaagccac catacaactc tttatgtgac agatgtaaaa ag                          42


<210>  88
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  88
aagagttgta tggtggcttt caatgagatt agactg                                 36


<210>  89
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  89

Cys Lys Glu Asp Glu Tyr Pro Val Gly Ser Glu Cys Cys Pro Lys Cys 
1               5                   10                  15      


Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu Thr Gly Thr 
            20                  25                  30          


Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His Leu Asn Gly 
        35                  40                  45              


Leu Ser Lys Cys Leu Gln Cys Gln Met Cys Ser Pro Ala Met Gly Leu 
    50                  55                  60                  


Arg Ala Ser Arg Asn Cys Ser Arg Thr Glu Asn Ala Val Cys 
65                  70                  75              


<210>  90
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  90

Cys Lys Pro Glu Glu Val Gln Gly Asn Cys Cys Pro Pro Cys Lys Gln 
1               5                   10                  15      


Gly Tyr Arg Val Thr Gly Gln Cys Thr Gln Tyr Thr Ala Thr Thr Cys 
            20                  25                  30          


Thr Leu Cys Pro Asn Gly Thr Tyr Val Ser Gly Leu Tyr Asn Cys Thr 
        35                  40                  45              


Asn Cys Thr Glu Cys Asn Asp Thr Glu Val Thr Ile Arg Asn Cys Thr 
    50                  55                  60                  


Ser Thr Asn Asn Thr Val Cys 
65                  70      


<210>  91
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  91

Cys Lys Gln Asp Glu Tyr Ala Val Gly Ser Glu Cys Cys Pro Lys Cys 
1               5                   10                  15      


Gly Lys Gly Tyr Arg Val Lys Thr Asn Cys Ser Glu Thr Thr Gly Thr 
            20                  25                  30          


Val Cys Glu Pro Cys Pro Ala Gly Ser Tyr Asn Asp Leu Arg Glu Thr 
        35                  40                  45              


Ile Cys Thr Gln Cys Asp Thr Cys Asn Ser Ser Ser Ile Ala Val Asn 
    50                  55                  60                  


Arg Cys Asn Thr Thr His Asn Val Arg Cys 
65                  70                  


