
                                SEQUENCE LISTING

<110> Gao, Feng
      Niu, Huifeng
      Shin, Hyunjin
      Zhang, Zhongfa
      Millennium Pharmaceuticals, Inc.

<120> BIOMARKERS OF RESPONSE TO SELECTIVE
  INHIBITORS OF AURORA A KINASE
  

<130> MPI15-008P1WOM

<140> 62/188,113          
<141> 2015-07-02  

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3620
<212> DNA
<213> Homo sapiens

<400> 1
agcgccggcg aggcgcggga ggaggagaag cagtggggag gcgcagccgc tcacctgcgg 60
ggcagggcgc ggaggaggga cccgggctgc gcgctctcgg gccgaggaac caggacgcgc 120
ccggagcctc gcacgcggcc aagctcgggg cgtcccctcc cctcggccgg gcgaactcaa 180
ggggcgcagc tctttgcttt gacagagctg gccggcggag gcgtgcagag cggcgagccg 240
gcgagccagg ctgagaaact cgagccggga acaaagaggg gtcggactga gtgtgtgtgt 300
cggctcgagc tccgggcaga ggcatttggg cccgaggccc ccgctgtgac tccccgagac 360
tccgcagtgc cctccactgc ggagtccccg cgcttgccgg caaaaacttt attcttggca 420
aacttctctt tctcttcccc tcctcctcgg cccccatctt ctgctcctcc tccttctcta 480
gcagattaaa tgagcctcga gaagaaaaac cgaagcgaaa gggaagaaaa taagaagatc 540
taaaacggac atctccagcg tgggtggctc ctttttcttt ttcttttttt cccacccttc 600
aggaagtgga cgtttcgtta tcttctgatc cttgcacctt cttttggggc aaacggggcc 660
cttctgccca gatcccctct cttttctcgg aaaacaaact actaagtcgg catccggggt 720
aactacagtg gagagggttt ccgcggagac gcgccgccgg accctcctct gcactttggg 780
gaggcgtgct ccctccagaa ccggcgttct ccgcgcgcaa atcccggcga cgcggggtcg 840
cggggtggcc gccggggcag cctcgtctag cgcgcgccgc gcagacgccc ccggagtcgc 900
cagctaccgc agccctcgcc gcccagtgcc cttcggcctc gggggcgggc gcctgcgtcg 960
gtctccgcga agcgggaaag cgcggcggcc gccgggattc gggcgccgcg gcagctgctc 1020
cggctgccgg ccggcggccc cgcgctcgcc cgccccgctt ccgcccgctg tcctgctgca 1080
cgaacccttc caactctcct ttcctccccc acccttgagt tacccctctg tctttcctgc 1140
tgttgcgcgg gtgctcccac agcggagcgg agattacaga gccgccggga tgccccaact 1200
ctccggagga ggtggcggcg gcggggggga cccggaactc tgcgccacgg acgagatgat 1260
ccccttcaag gacgagggcg atcctcagaa ggaaaagatc ttcgccgaga tcagtcatcc 1320
cgaagaggaa ggcgatttag ctgacatcaa gtcttccttg gtgaacgagt ctgaaatcat 1380
cccggccagc aacggacacg aggtggccag acaagcacaa acctctcagg agccctacca 1440
cgacaaggcc agagaacacc ccgatgacgg aaagcatcca gatggaggcc tctacaacaa 1500
gggaccctcc tactcgagtt attccgggta cataatgatg ccaaatatga ataacgaccc 1560
atacatgtca aatggatctc tttctccacc catcccgaga acatcaaata aagtgcccgt 1620
ggtgcagcca tcccatgcgg tccatcctct cacccccctc atcacttaca gtgacgagca 1680
cttttctcca ggatcacacc cgtcacacat cccatcagat gtcaactcca aacaaggcat 1740
gtccagacat cctccagctc ctgatatccc tactttttat cccttgtctc cgggtggtgt 1800
tggacagatc accccacctc ttggctggca aggtcagcct gtatatccca tcacgggtgg 1860
attcaggcaa ccctacccat cctcactgtc agtcgacact tccatgtcca ggttttccca 1920
tcatatgatt cccggtcctc ctggtcccca cacaactggc atccctcatc cagctattgt 1980
aacacctcag gtcaaacagg aacatcccca cactgacagt gacctaatgc acgtgaagcc 2040
tcagcatgaa cagagaaagg agcaggagcc aaaaagacct cacattaaga agcctctgaa 2100
tgcttttatg ttatacatga aagaaatgag agcgaatgtc gttgctgagt gtactctaaa 2160
agaaagtgca gctatcaacc agattcttgg cagaaggtgg catgccctct cccgtgaaga 2220
gcaggctaaa tattatgaat tagcacggaa agaaagacag ctacatatgc agctttatcc 2280
aggctggtct gcaagagaca attatggtaa gaaaaagaag aggaagagag agaaactaca 2340
ggaatctgca tcaggtacag gtccaagaat gacagctgcc tacatctgaa acatggtgga 2400
aaacgaagct cattcccaac gtgcaaagcc aaggcagcga ccccaggacc tcttctggag 2460
atggaagctt gttgaaaacc cagactgtct ccacggcctg cccagtcgac cccaaaggaa 2520
cactgacatc aattttaccc tgaggtcact gctagagacg ctgatccata aagacaatca 2580
ctgccaaccc ctctttcgtc tactgcaaga gccaagttcc aaaataaagc ataaaaaggt 2640
tttttaaaag gaaatgtaaa agcacatgag aatgctagca ggctgtgggg cagctgagca 2700
gcttttctcc cctcatatct gcgtgcactt cccagagcat cttgcatcca aacctgtaac 2760
ctttcggcaa ggacggtaac ttggctgcat ttgcctgtca tgcgcaactg gagccagcaa 2820
ccagcacatc catcagcacc ccagtggagg agttcatgga agagttccct ctttgtttct 2880
gcttcatttt tctttctttt cttttctcct aaagctttta tttaacagtg caaaaggatc 2940
gttttttttt gcttttttaa acttgaattt ttttaattta cactttttag ttttaatttt 3000
cttgtatatt ttgctagcta tgagctttta aataaaattg aaagttctgg aaaagtttga 3060
aataatgaca taaaaagaag ccttcttttt ctgagacagc ttgtctggta agtggcttct 3120
ctgtgaattg cctgtaacac atagtggctt ctccgccctt gtaaggtgtt cagtagagct 3180
aaataaatgt aatagccaaa cccactctgt tggtagcaat tggcagccct atttcagttt 3240
attttttctt ctgttttctt cttttctttt tttaaacagt aaaccttaac agatgcgttc 3300
agcagactgg tttgcagtga attttcattt ctttccttat cacccccttg ttgtaaaaag 3360
cccagcactt gaattgttat tactttaaat gttctgtatt tgtatctgtt tttattagcc 3420
aattagtggg attttatgcc agttgttaaa atgagcattg atgtacccat tttttaaaaa 3480
agcaaggcac agcctttgcc caaaactgtc atcctaacgt ttgtcattcc agtttgagtt 3540
aatgtgctga gcattttttt aaaagaagct ttgtaataaa acatttttaa aaattgtcat 3600
ttaaaaaaaa aaaaaaaaaa                                             3620

<210> 2
<211> 399
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu
 1               5                  10                  15      
Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro
            20                  25                  30          
Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly
        35                  40                  45              
Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile
    50                  55                  60                  
Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln
65                  70                  75                  80  
Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His
                85                  90                  95      
Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser
            100                 105                 110         
Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn
        115                 120                 125             
Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val
    130                 135                 140                 
Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr
145                 150                 155                 160 
Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser
                165                 170                 175     
Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp
            180                 185                 190         
Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr
        195                 200                 205             
Pro Pro Leu Gly Trp Gln Gly Gln Pro Val Tyr Pro Ile Thr Gly Gly
    210                 215                 220                 
Phe Arg Gln Pro Tyr Pro Ser Ser Leu Ser Val Asp Thr Ser Met Ser
225                 230                 235                 240 
Arg Phe Ser His His Met Ile Pro Gly Pro Pro Gly Pro His Thr Thr
                245                 250                 255     
Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val Lys Gln Glu His
            260                 265                 270         
Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro Gln His Glu Gln
        275                 280                 285             
Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys Lys Pro Leu Asn
    290                 295                 300                 
Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn Val Val Ala Glu
305                 310                 315                 320 
Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg
                325                 330                 335     
Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala
            340                 345                 350         
Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala
        355                 360                 365             
Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Glu Lys Leu Gln
    370                 375                 380                 
Glu Ser Ala Ser Gly Thr Gly Pro Arg Met Thr Ala Ala Tyr Ile
385                 390                 395                 

<210> 3
<211> 5172
<212> DNA
<213> Homo sapiens

<400> 3
gtcctctctc gcggtatcat ccggttgctg aggccctgta ataaaggtct cgcgaaattt 60
gttctagagg tccaagtttg cttcttagct tactccaccc cacccccaac ctgtccctcc 120
ttttctttcc aagtcacaaa attctcccct cccctacccc ggagtttacg gccctcctcc 180
tgtttccgat ttcagcccgg aaccggaagt gtagtgggcg gggcccgtcg gcggaaaacg 240
cagcggagcc agagccggac acggctgtgg ccgctgcctc tacccccgcc acggatcgcc 300
gggtagtagg actgcgcggc tccaggctga gggtcggtcc ggaggcgggt gggcgcgggt 360
ctcacccgga ttgtccgggt ggcaccgttc ccggccccac cgggcgccgc gagggatcat 420
gtctacagcc tctgccgcct cctcctcctc ctcgtcttcg gccggtgaga tgatcgaagc 480
cccttcccag gtcctcaact ttgaagagat cgactacaag gagatcgagg tggaagaggt 540
tgttggaaga ggagcctttg gagttgtttg caaagctaag tggagagcaa aagatgttgc 600
tattaaacaa atagaaagtg aatctgagag gaaagcgttt attgtagagc ttcggcagtt 660
atcccgtgtg aaccatccta atattgtaaa gctttatgga gcctgcttga atccagtgtg 720
tcttgtgatg gaatatgctg aagggggctc tttatataat gtgctgcatg gtgctgaacc 780
attgccatat tatactgctg cccacgcaat gagttggtgt ttacagtgtt cccaaggagt 840
ggcttatctt cacagcatgc aacccaaagc gctaattcac agggacctga aaccaccaaa 900
cttactgctg gttgcagggg ggacagttct aaaaatttgt gattttggta cagcctgtga 960
cattcagaca cacatgacca ataacaaggg gagtgctgct tggatggcac ctgaagtttt 1020
tgaaggtagt aattacagtg aaaaatgtga cgtcttcagc tggggtatta ttctttggga 1080
agtgataacg cgtcggaaac cctttgatga gattggtggc ccagctttcc gaatcatgtg 1140
ggctgttcat aatggtactc gaccaccact gataaaaaat ttacctaagc ccattgagag 1200
cctgatgact cgttgttggt ctaaagatcc ttcccagcgc ccttcaatgg aggaaattgt 1260
gaaaataatg actcacttga tgcggtactt tccaggagca gatgagccat tacagtatcc 1320
ttgtcagtat tcagatgaag gacagagcaa ctctgccacc agtacaggct cattcatgga 1380
cattgcttct acaaatacga gtaacaaaag tgacactaat atggagcaag ttcctgccac 1440
aaatgatact attaagcgct tagaatcaaa attgttgaaa aatcaggcaa agcaacagag 1500
tgaatctgga cgtttaagct tgggagcctc ccgtgggagc agtgtggaga gcttgccccc 1560
aacctctgag ggcaagagga tgagtgctga catgtctgaa atagaagcta ggatcgccgc 1620
aaccacagcc tattccaagc ctaaacgggg ccaccgtaaa actgcttcat ttggcaacat 1680
tctggatgtc cctgagatcg tcatatcagg caacggacag ccaagacgta gatccatcca 1740
agacttgact gtaactggaa cagaacctgg tcaggtgagc agtaggtcat ccagtcccag 1800
tgtcagaatg attactacct caggaccaac ctcagaaaag ccaactcgaa gtcatccatg 1860
gacccctgat gattccacag ataccaatgg atcagataac tccatcccaa tggcttatct 1920
tacactggat caccaactac agcctctagc accgtgccca aactccaaag aatctatggc 1980
agtgtttgaa cagcattgta aaatggcaca agaatatatg aaagttcaaa cagaaattgc 2040
attgttatta cagagaaagc aagaactagt tgcagaactg gaccaggatg aaaaggacca 2100
gcaaaataca tctcgcctgg tacaggaaca taaaaagctt ttagatgaaa acaaaagcct 2160
ttctacttac taccagcaat gcaaaaaaca actagaggtc atcagaagtc agcagcagaa 2220
acgacaaggc acttcatgat tctctgggac cgttacattt tgaaatatgc aaagaaagac 2280
ttttttttta aggaaaggaa aaccttataa tgacgattca tgagtgttag ctttttggcg 2340
tgttctgaat gccaactgcc tatatttgct gcattttttt cattgtttat tttccttttc 2400
tcatggtgga catacaattt tactgtttca ttgcataaca tggtagcatc tgtgacttga 2460
atgagcagca ctttgcaact tcaaaacaga tgcagtgaac tgtggctgta tatgcatgct 2520
cattgtgtga aggctagcct aacagaacag gaggtatcaa actagctgct atgtgcaaac 2580
agcgtccatt ttttcatatt agaggtggaa cctcaagaat gactttattc ttgtatctca 2640
tctcaaaata ttaataattt ttttcccaaa agatggtata taccaagtta aagacagggt 2700
attataaatt tagagtgatt ggtggtatat tacggaaata cggaaccttt agggatagtt 2760
ccgtgtaagg gctttgatgc cagcatcctt ggatcagtac tgaactcagt tccatccgta 2820
aaatatgtaa aggtaagtgg cagctgctct atttaatgaa agcagtttta ccggattttg 2880
ttagactaaa atttgattgt gatacattga acaaaatgga actcattttt ttttaaggag 2940
taaagatttt taattctgtg attgtgtgta tgtgtgttga aactgtaaag cttttatgac 3000
tctaatatta atctcttaaa tgaaattaaa aggcaaaaga acatgattga gcttaaatga 3060
tcatttcttc ctgcagtgat tcttggattg ttttctcatg tatttgaaaa aaaaaaaatg 3120
aagaaaaata atggaaaatg gaagtaatta ctccagctaa aaaaagcttg gacttagatt 3180
tctttttatg ataccaaatg agaaataaac caggcaaatc agaaggaagt taaagaagca 3240
aatataaatt caacaagtgt cctaattatc ctggatattg gaatatttga ttttccttac 3300
aatcccgttc tagaatgcct gccgcctttc aacactttca agagaatttc aacacttaca 3360
gagtatttat attgttaaca gtaattttgc taccaaaacc ttcagaataa ctttaataat 3420
aaaatgacac tgaaataata gactatacaa actctatatt ttttcagttg gtgttaaaat 3480
aagtcacatt ttgataccag tacaagatgt cttttaaata aggatgtcat cagtctgatt 3540
tttatagcat taatgtttta tgaagaaaaa gttcaaaatg aaagcattaa ttgctgtgat 3600
tattagaatt ctatcatgac tgtattgtag tttttgctct atttcagata agcaagatct 3660
aagaagttat caaaactatt ctttaaaatg ctaaagcagg taactttttc ttccattatt 3720
ttttcctcct accactgagt tttgtaatga attccttgtg tatacaagca atacaggtga 3780
atactaaact gttattttta gcttcttcaa aagctatttt agaaagcttc ctggaaataa 3840
atgtcttctg tcatttaatt taaataaaag gagtgttaat tgttcccaaa tttgattacc 3900
tagctgaaac agatattgga ttcagcatag taatagtaaa ataaaattgg cagagaaaat 3960
aactgtagac taggataaag catgactcct ccatagcatt gttgcttgta tgtacatctg 4020
tcactccact gaaagggacc tagtcacttt aaagaggcct tttatctcag cacgagatat 4080
ccaagcgtga atgctaaggc ttgatgtttc cattaggatt tagcattcga gatttcagat 4140
tttatttata gtcattgatg tgttttgctg tattataaca catttaaggg aaattttatt 4200
atggttttta catgtagtca tttcataaaa atatccagat aggtaaatgg aagaaaatag 4260
tagattttag tcatggtacc aaatgcaaga ggctgttgaa cagttgcttg tttgtttaca 4320
gtaagttcct tgagattttc agtactgtag ttgccctgga cattgagtac agttcagcct 4380
tactctgttt ttaagtagtt gtgttgtcaa tttcatgctt ttaagtcctg atgatccttg 4440
gagatgggag aaaaagatac cagggataat taaaatccac agccagtttc atcagtttcc 4500
tcatccatcc tgcaaataaa aatgttaaca aggagccaaa cttattcgtt ctggttttac 4560
aatttatttt gaccgttttt tgggtgaaaa ttgcaaacag ccaagcaagt ggctggaatg 4620
ccccagtcta agaaattcaa aaacaatcac tgagtaagcc ctaattacat taattacatt 4680
ttactcttga ctccaggaaa agaaagcaag cttttatcta atctagaggg aagtattcgt 4740
gagcaataaa aatcactttt ttgagttgaa taataatcag ttaagaatat ttaccgcata 4800
gcaacacaac atataaagat ttgttacaag ttgtttacgg atgtttgact atttttgctg 4860
aagtatttta gagtattgaa tgtcttctct cttcaagttt ctttcatgtt cctaatttca 4920
gctcctgtag ccagagatca caggtcttcc ctgtgaaact ttggtttctt tctataaatg 4980
tgtgtggttt tcagcgctca actcctgtct tcaaatggta gtaagttcta cttctacttc 5040
tgtcattcag aacattttat gtcaaatgat gtaatgcaga aattcttgtg catatttgta 5100
actgaaggaa gctttttaga tttatttttg tttttaataa aattcagatt cctattctaa 5160
actggtaaaa aa                                                     5172


<210> 4
<211> 606
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly
 1               5                  10                  15      
Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp
            20                  25                  30          
Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly
        35                  40                  45              
Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln
    50                  55                  60                  
Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln
65                  70                  75                  80  
Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys
                85                  90                  95      
Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu
            100                 105                 110         
Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala
        115                 120                 125             
His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu
    130                 135                 140                 
His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro
145                 150                 155                 160 
Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe
                165                 170                 175     
Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser
            180                 185                 190         
Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu
        195                 200                 205             
Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr
    210                 215                 220                 
Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met
225                 230                 235                 240 
Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro
                245                 250                 255     
Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser
            260                 265                 270         
Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met
        275                 280                 285             
Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr
    290                 295                 300                 
Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met
305                 310                 315                 320 
Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu
                325                 330                 335     
Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu
            340                 345                 350         
Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu
        355                 360                 365             
Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu
    370                 375                 380                 
Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala
385                 390                 395                 400 
Ala Thr Thr Ala Tyr Ser Lys Pro Lys Arg Gly His Arg Lys Thr Ala
                405                 410                 415     
Ser Phe Gly Asn Ile Leu Asp Val Pro Glu Ile Val Ile Ser Gly Asn
            420                 425                 430         
Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu Thr Val Thr Gly Thr
        435                 440                 445             
Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser Pro Ser Val Arg Met
    450                 455                 460                 
Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro Thr Arg Ser His Pro
465                 470                 475                 480 
Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly Ser Asp Asn Ser Ile
                485                 490                 495     
Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu Gln Pro Leu Ala Pro
            500                 505                 510         
Cys Pro Asn Ser Lys Glu Ser Met Ala Val Phe Glu Gln His Cys Lys
        515                 520                 525             
Met Ala Gln Glu Tyr Met Lys Val Gln Thr Glu Ile Ala Leu Leu Leu
    530                 535                 540                 
Gln Arg Lys Gln Glu Leu Val Ala Glu Leu Asp Gln Asp Glu Lys Asp
545                 550                 555                 560 
Gln Gln Asn Thr Ser Arg Leu Val Gln Glu His Lys Lys Leu Leu Asp
                565                 570                 575     
Glu Asn Lys Ser Leu Ser Thr Tyr Tyr Gln Gln Cys Lys Lys Gln Leu
            580                 585                 590         
Glu Val Ile Arg Ser Gln Gln Gln Lys Arg Gln Gly Thr Ser
        595                 600                 605     

<210> 5
<211> 10740
<212> DNA
<213> Homo sapiens

<400> 5
gtattggtgc agcccgccag ggtgtcactg gagacagaat ggaggtgctg ccggactcgg 60
aaatggggtc caagggtagc caaggatggc tgcagcttca tatgatcagt tgttaaagca 120
agttgaggca ctgaagatgg agaactcaaa tcttcgacaa gagctagaag ataattccaa 180
tcatcttaca aaactggaaa ctgaggcatc taatatgaag gaagtactta aacaactaca 240
aggaagtatt gaagatgaag ctatggcttc ttctggacag attgatttat tagagcgtct 300
taaagagctt aacttagata gcagtaattt ccctggagta aaactgcggt caaaaatgtc 360
cctccgttct tatggaagcc gggaaggatc tgtatcaagc cgttctggag agtgcagtcc 420
tgttcctatg ggttcatttc caagaagagg gtttgtaaat ggaagcagag aaagtactgg 480
atatttagaa gaacttgaga aagagaggtc attgcttctt gctgatcttg acaaagaaga 540
aaaggaaaaa gactggtatt acgctcaact tcagaatctc actaaaagaa tagatagtct 600
tcctttaact gaaaattttt ccttacaaac agatatgacc agaaggcaat tggaatatga 660
agcaaggcaa atcagagttg cgatggaaga acaactaggt acctgccagg atatggaaaa 720
acgagcacag cgaagaatag ccagaattca gcaaatcgaa aaggacatac ttcgtatacg 780
acagctttta cagtcccaag caacagaagc agagaggtca tctcagaaca agcatgaaac 840
cggctcacat gatgctgagc ggcagaatga aggtcaagga gtgggagaaa tcaacatggc 900
aacttctggt aatggtcagg gttcaactac acgaatggac catgaaacag ccagtgtttt 960
gagttctagt agcacacact ctgcacctcg aaggctgaca agtcatctgg gaaccaaggt 1020
ggaaatggtg tattcattgt tgtcaatgct tggtactcat gataaggatg atatgtcgcg 1080
aactttgcta gctatgtcta gctcccaaga cagctgtata tccatgcgac agtctggatg 1140
tcttcctctc ctcatccagc ttttacatgg caatgacaaa gactctgtat tgttgggaaa 1200
ttcccggggc agtaaagagg ctcgggccag ggccagtgca gcactccaca acatcattca 1260
ctcacagcct gatgacaaga gaggcaggcg tgaaatccga gtccttcatc ttttggaaca 1320
gatacgcgct tactgtgaaa cctgttggga gtggcaggaa gctcatgaac caggcatgga 1380
ccaggacaaa aatccaatgc cagctcctgt tgaacatcag atctgtcctg ctgtgtgtgt 1440
tctaatgaaa ctttcatttg atgaagagca tagacatgca atgaatgaac tagggggact 1500
acaggccatt gcagaattat tgcaagtgga ctgtgaaatg tatgggctta ctaatgacca 1560
ctacagtatt acactaagac gatatgctgg aatggctttg acaaacttga cttttggaga 1620
tgtagccaac aaggctacgc tatgctctat gaaaggctgc atgagagcac ttgtggccca 1680
actaaaatct gaaagtgaag acttacagca ggttattgcg agtgttttga ggaatttgtc 1740
ttggcgagca gatgtaaata gtaaaaagac gttgcgagaa gttggaagtg tgaaagcatt 1800
gatggaatgt gctttagaag ttaaaaagga atcaaccctc aaaagcgtat tgagtgcctt 1860
atggaatttg tcagcacatt gcactgagaa taaagctgat atatgtgctg tagatggtgc 1920
acttgcattt ttggttggca ctcttactta ccggagccag acaaacactt tagccattat 1980
tgaaagtgga ggtgggatat tacggaatgt gtccagcttg atagctacaa atgaggacca 2040
caggcaaatc ctaagagaga acaactgtct acaaacttta ttacaacact taaaatctca 2100
tagtttgaca atagtcagta atgcatgtgg aactttgtgg aatctctcag caagaaatcc 2160
taaagaccag gaagcattat gggacatggg ggcagttagc atgctcaaga acctcattca 2220
ttcaaagcac aaaatgattg ctatgggaag tgctgcagct ttaaggaatc tcatggcaaa 2280
taggcctgcg aagtacaagg atgccaatat tatgtctcct ggctcaagct tgccatctct 2340
tcatgttagg aaacaaaaag ccctagaagc agaattagat gctcagcact tatcagaaac 2400
ttttgacaat atagacaatt taagtcccaa ggcatctcat cgtagtaagc agagacacaa 2460
gcaaagtctc tatggtgatt atgtttttga caccaatcga catgatgata ataggtcaga 2520
caattttaat actggcaaca tgactgtcct ttcaccatat ttgaatacta cagtgttacc 2580
cagctcctct tcatcaagag gaagcttaga tagttctcgt tctgaaaaag atagaagttt 2640
ggagagagaa cgcggaattg gtctaggcaa ctaccatcca gcaacagaaa atccaggaac 2700
ttcttcaaag cgaggtttgc agatctccac cactgcagcc cagattgcca aagtcatgga 2760
agaagtgtca gccattcata cctctcagga agacagaagt tctgggtcta ccactgaatt 2820
acattgtgtg acagatgaga gaaatgcact tagaagaagc tctgctgccc atacacattc 2880
aaacacttac aatttcacta agtcggaaaa ttcaaatagg acatgttcta tgccttatgc 2940
caaattagaa tacaagagat cttcaaatga tagtttaaat agtgtcagta gtagtgatgg 3000
ttatggtaaa agaggtcaaa tgaaaccctc gattgaatcc tattctgaag atgatgaaag 3060
taagttttgc agttatggtc aatacccagc cgacctagcc cataaaatac atagtgcaaa 3120
tcatatggat gataatgatg gagaactaga tacaccaata aattatagtc ttaaatattc 3180
agatgagcag ttgaactctg gaaggcaaag tccttcacag aatgaaagat gggcaagacc 3240
caaacacata atagaagatg aaataaaaca aagtgagcaa agacaatcaa ggaatcaaag 3300
tacaacttat cctgtttata ctgagagcac tgatgataaa cacctcaagt tccaaccaca 3360
ttttggacag caggaatgtg tttctccata caggtcacgg ggagccaatg gttcagaaac 3420
aaatcgagtg ggttctaatc atggaattaa tcaaaatgta agccagtctt tgtgtcaaga 3480
agatgactat gaagatgata agcctaccaa ttatagtgaa cgttactctg aagaagaaca 3540
gcatgaagaa gaagagagac caacaaatta tagcataaaa tataatgaag agaaacgtca 3600
tgtggatcag cctattgatt atagtttaaa atatgccaca gatattcctt catcacagaa 3660
acagtcattt tcattctcaa agagttcatc tggacaaagc agtaaaaccg aacatatgtc 3720
ttcaagcagt gagaatacgt ccacaccttc atctaatgcc aagaggcaga atcagctcca 3780
tccaagttct gcacagagta gaagtggtca gcctcaaaag gctgccactt gcaaagtttc 3840
ttctattaac caagaaacaa tacagactta ttgtgtagaa gatactccaa tatgtttttc 3900
aagatgtagt tcattatcat ctttgtcatc agctgaagat gaaataggat gtaatcagac 3960
gacacaggaa gcagattctg ctaataccct gcaaatagca gaaataaaag aaaagattgg 4020
aactaggtca gctgaagatc ctgtgagcga agttccagca gtgtcacagc accctagaac 4080
caaatccagc agactgcagg gttctagttt atcttcagaa tcagccaggc acaaagctgt 4140
tgaattttct tcaggagcga aatctccctc caaaagtggt gctcagacac ccaaaagtcc 4200
acctgaacac tatgttcagg agaccccact catgtttagc agatgtactt ctgtcagttc 4260
acttgatagt tttgagagtc gttcgattgc cagctccgtt cagagtgaac catgcagtgg 4320
aatggtaagt ggcattataa gccccagtga tcttccagat agccctggac aaaccatgcc 4380
accaagcaga agtaaaacac ctccaccacc tcctcaaaca gctcaaacca agcgagaagt 4440
acctaaaaat aaagcaccta ctgctgaaaa gagagagagt ggacctaagc aagctgcagt 4500
aaatgctgca gttcagaggg tccaggttct tccagatgct gatactttat tacattttgc 4560
cacggaaagt actccagatg gattttcttg ttcatccagc ctgagtgctc tgagcctcga 4620
tgagccattt atacagaaag atgtggaatt aagaataatg cctccagttc aggaaaatga 4680
caatgggaat gaaacagaat cagagcagcc taaagaatca aatgaaaacc aagagaaaga 4740
ggcagaaaaa actattgatt ctgaaaagga cctattagat gattcagatg atgatgatat 4800
tgaaatacta gaagaatgta ttatttctgc catgccaaca aagtcatcac gtaaagcaaa 4860
aaagccagcc cagactgctt caaaattacc tccacctgtg gcaaggaaac caagtcagct 4920
gcctgtgtac aaacttctac catcacaaaa caggttgcaa ccccaaaagc atgttagttt 4980
tacaccgggg gatgatatgc cacgggtgta ttgtgttgaa gggacaccta taaacttttc 5040
cacagctaca tctctaagtg atctaacaat cgaatcccct ccaaatgagt tagctgctgg 5100
agaaggagtt agaggagggg cacagtcagg tgaatttgaa aaacgagata ccattcctac 5160
agaaggcaga agtacagatg aggctcaagg aggaaaaacc tcatctgtaa ccatacctga 5220
attggatgac aataaagcag aggaaggtga tattcttgca gaatgcatta attctgctat 5280
gcccaaaggg aaaagtcaca agcctttccg tgtgaaaaag ataatggacc aggtccagca 5340
agcatctgcg tcttcttctg cacccaacaa aaatcagtta gatggtaaga aaaagaaacc 5400
aacttcacca gtaaaaccta taccacaaaa tactgaatat aggacacgtg taagaaaaaa 5460
tgcagactca aaaaataatt taaatgctga gagagttttc tcagacaaca aagattcaaa 5520
gaaacagaat ttgaaaaata attccaaggt cttcaatgat aagctcccaa ataatgaaga 5580
tagagtcaga ggaagttttg cttttgattc acctcatcat tacacgccta ttgaaggaac 5640
tccttactgt ttttcacgaa atgattcttt gagttctcta gattttgatg atgatgatgt 5700
tgacctttcc agggaaaagg ctgaattaag aaaggcaaaa gaaaataagg aatcagaggc 5760
taaagttacc agccacacag aactaacctc caaccaacaa tcagctaata agacacaagc 5820
tattgcaaag cagccaataa atcgaggtca gcctaaaccc atacttcaga aacaatccac 5880
ttttccccag tcatccaaag acataccaga cagaggggca gcaactgatg aaaagttaca 5940
gaattttgct attgaaaata ctccggtttg cttttctcat aattcctctc tgagttctct 6000
cagtgacatt gaccaagaaa acaacaataa agaaaatgaa cctatcaaag agactgagcc 6060
ccctgactca cagggagaac caagtaaacc tcaagcatca ggctatgctc ctaaatcatt 6120
tcatgttgaa gataccccag tttgtttctc aagaaacagt tctctcagtt ctcttagtat 6180
tgactctgaa gatgacctgt tgcaggaatg tataagctcc gcaatgccaa aaaagaaaaa 6240
gccttcaaga ctcaagggtg ataatgaaaa acatagtccc agaaatatgg gtggcatatt 6300
aggtgaagat ctgacacttg atttgaaaga tatacagaga ccagattcag aacatggtct 6360
atcccctgat tcagaaaatt ttgattggaa agctattcag gaaggtgcaa attccatagt 6420
aagtagttta catcaagctg ctgctgctgc atgtttatct agacaagctt cgtctgattc 6480
agattccatc ctttccctga aatcaggaat ctctctggga tcaccatttc atcttacacc 6540
tgatcaagaa gaaaaaccct ttacaagtaa taaaggccca cgaattctaa aaccagggga 6600
gaaaagtaca ttggaaacta aaaagataga atctgaaagt aaaggaatca aaggaggaaa 6660
aaaagtttat aaaagtttga ttactggaaa agttcgatct aattcagaaa tttcaggcca 6720
aatgaaacag ccccttcaag caaacatgcc ttcaatctct cgaggcagga caatgattca 6780
tattccagga gttcgaaata gctcctcaag tacaagtcct gtttctaaaa aaggcccacc 6840
ccttaagact ccagcctcca aaagccctag tgaaggtcaa acagccacca cttctcctag 6900
aggagccaag ccatctgtga aatcagaatt aagccctgtt gccaggcaga catcccaaat 6960
aggtgggtca agtaaagcac cttctagatc aggatctaga gattcgaccc cttcaagacc 7020
tgcccagcaa ccattaagta gacctataca gtctcctggc cgaaactcaa tttcccctgg 7080
tagaaatgga ataagtcctc ctaacaaatt atctcaactt ccaaggacat catcccctag 7140
tactgcttca actaagtcct caggttctgg aaaaatgtca tatacatctc caggtagaca 7200
gatgagccaa cagaacctta ccaaacaaac aggtttatcc aagaatgcca gtagtattcc 7260
aagaagtgag tctgcctcca aaggactaaa tcagatgaat aatggtaatg gagccaataa 7320
aaaggtagaa ctttctagaa tgtcttcaac taaatcaagt ggaagtgaat ctgatagatc 7380
agaaagacct gtattagtac gccagtcaac tttcatcaaa gaagctccaa gcccaacctt 7440
aagaagaaaa ttggaggaat ctgcttcatt tgaatctctt tctccatcat ctagaccagc 7500
ttctcccact aggtcccagg cacaaactcc agttttaagt ccttcccttc ctgatatgtc 7560
tctatccaca cattcgtctg ttcaggctgg tggatggcga aaactcccac ctaatctcag 7620
tcccactata gagtataatg atggaagacc agcaaagcgc catgatattg cacggtctca 7680
ttctgaaagt ccttctagac ttccaatcaa taggtcagga acctggaaac gtgagcacag 7740
caaacattca tcatcccttc ctcgagtaag cacttggaga agaactggaa gttcatcttc 7800
aattctttct gcttcatcag aatccagtga aaaagcaaaa agtgaggatg aaaaacatgt 7860
gaactctatt tcaggaacca aacaaagtaa agaaaaccaa gtatccgcaa aaggaacatg 7920
gagaaaaata aaagaaaatg aattttctcc cacaaatagt acttctcaga ccgtttcctc 7980
aggtgctaca aatggtgctg aatcaaagac tctaatttat caaatggcac ctgctgtttc 8040
taaaacagag gatgtttggg tgagaattga ggactgtccc attaacaatc ctagatctgg 8100
aagatctccc acaggtaata ctcccccggt gattgacagt gtttcagaaa aggcaaatcc 8160
aaacattaaa gattcaaaag ataatcaggc aaaacaaaat gtgggtaatg gcagtgttcc 8220
catgcgtacc gtgggtttgg aaaatcgcct gaactccttt attcaggtgg atgcccctga 8280
ccaaaaagga actgagataa aaccaggaca aaataatcct gtccctgtat cagagactaa 8340
tgaaagttct atagtggaac gtaccccatt cagttctagc agctcaagca aacacagttc 8400
acctagtggg actgttgctg ccagagtgac tccttttaat tacaacccaa gccctaggaa 8460
aagcagcgca gatagcactt cagctcggcc atctcagatc ccaactccag tgaataacaa 8520
cacaaagaag cgagattcca aaactgacag cacagaatcc agtggaaccc aaagtcctaa 8580
gcgccattct gggtcttacc ttgtgacatc tgtttaaaag agaggaagaa tgaaactaag 8640
aaaattctat gttaattaca actgctatat agacattttg tttcaaatga aactttaaaa 8700
gactgaaaaa ttttgtaaat aggtttgatt cttgttagag ggtttttgtt ctggaagcca 8760
tatttgatag tatactttgt cttcactggt cttattttgg gaggcactct tgatggttag 8820
gaaaaaaata gtaaagccaa gtatgtttgt acagtatgtt ttacatgtat ttaaagtagc 8880
atcccatccc aacttccttt aattattgct tgtcttaaaa taatgaacac tacagataga 8940
aaatatgata tattgctgtt atcaatcatt tctagattat aaactgacta aacttacatc 9000
agggaaaaat tggtatttat gcaaaaaaaa atgtttttgt ccttgtgagt ccatctaaca 9060
tcataattaa tcatgtggct gtgaaattca cagtaatatg gttcccgatg aacaagttta 9120
cccagcctgc tttgctttac tgcatgaatg aaactgatgg ttcaatttca gaagtaatga 9180
ttaacagtta tgtggtcaca tgatgtgcat agagatagct acagtgtaat aatttacact 9240
attttgtgct ccaaacaaaa caaaaatctg tgtaactgta aaacattgaa tgaaactatt 9300
ttacctgaac tagattttat ctgaaagtag gtagaatttt tgctatgctg taatttgttg 9360
tatattctgg tatttgaggt gagatggctg ctcttttatt aatgagacat gaattgtgtc 9420
tcaacagaaa ctaaatgaac atttcagaat aaattattgc tgtatgtaaa ctgttactga 9480
aattggtatt tgtttgaagg gtcttgtttc acatttgtat taataattgt ttaaaatgcc 9540
tcttttaaaa gcttatataa atttttttct tcagcttcta tgcattaaga gtaaaattcc 9600
tcttactgta ataaaaacaa ttgaagaaga ctgttgccac ttaaccattc catgcgttgg 9660
cacttatcta ttcctgaaat ttcttttatg tgattagctc atcttgattt ttaatatttt 9720
tccacttaaa cttttttttc ttactccact ggagctcagt aaaagtaaat tcatgtaata 9780
gcaatgcaag cagcctagca cagactaagc attgagcata ataggcccac ataatttcct 9840
ctttcttaat attatagaat tctgtacttg aaattgattc ttagacattg cagtctcttc 9900
gaggctttac agtgtaaact gtcttgcccc ttcatcttct tgttgcaact gggtctgaca 9960
tgaacacttt ttatcaccct gtatgttagg gcaagatctc agcagtgaag tataatcagc 10020
actttgccat gctcagaaaa ttcaaatcac atggaacttt agaggtagat ttaatacgat 10080
taagatattc agaagtatat tttagaatcc ctgcctgtta aggaaacttt atttgtggta 10140
ggtacagttc tggggtacat gttaagtgtc cccttataca gtggagggaa gtcttccttc 10200
ctgaaggaaa ataaactgac acttattaac taagataatt tacttaatat atcttccctg 10260
atttgtttta aaagatcaga gggtgactga tgatacatgc atacatattt gttgaataaa 10320
tgaaaattta tttttagtga taagattcat acactctgta tttggggagg gaaaaccttt 10380
ttaagcatgg tggggcactc agataggagt gaatacacct acctggtgcc ttgaaaatca 10440
catcaagtag ttaattatct accccttacc tgtgtttata acttccaggt aatgagaatg 10500
atttttttta aagctaaaat gccagtaaat aaaagtgcta tgacttgagc taagatattt 10560
gactccaatg cctgtactgt gtctactgca ccactttgta aacacttcaa tttactatct 10620
ttgaaatgat tgacctttaa atttttgcca aatgttatct gaaattgtct atgaatacca 10680
tctacttctg ttgttttccc aggcttccat aaacaatgga gatacatgca aaaaaaaaaa 10740

<210> 6
<211> 2843
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu
 1               5                  10                  15      
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn
            20                  25                  30          
His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu
        35                  40                  45              
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly
    50                  55                  60                  
Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser
65                  70                  75                  80  
Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr
                85                  90                  95      
Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro
            100                 105                 110         
Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg
        115                 120                 125             
Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu
    130                 135                 140                 
Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala
145                 150                 155                 160 
Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu
                165                 170                 175     
Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu
            180                 185                 190         
Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln
        195                 200                 205             
Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile
    210                 215                 220                 
Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr
225                 230                 235                 240 
Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp
                245                 250                 255     
Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala
            260                 265                 270         
Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr
        275                 280                 285             
Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu
    290                 295                 300                 
Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser
305                 310                 315                 320 
Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala
                325                 330                 335     
Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys
            340                 345                 350         
Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val
        355                 360                 365             
Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser
    370                 375                 380                 
Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly
385                 390                 395                 400 
Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr
                405                 410                 415     
Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp
            420                 425                 430         
Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro
        435                 440                 445             
Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His
    450                 455                 460                 
Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln
465                 470                 475                 480 
Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr
                485                 490                 495     
Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp
            500                 505                 510         
Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala
        515                 520                 525             
Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile
    530                 535                 540                 
Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys
545                 550                 555                 560 
Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala
                565                 570                 575     
Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu
            580                 585                 590         
Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala
        595                 600                 605             
Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser
    610                 615                 620                 
Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg
625                 630                 635                 640 
Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu
                645                 650                 655     
Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His
            660                 665                 670         
Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser
        675                 680                 685             
Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val
    690                 695                 700                 
Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met
705                 710                 715                 720 
Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys
                725                 730                 735     
Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu
            740                 745                 750         
His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His
        755                 760                 765             
Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser
    770                 775                 780                 
His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val
785                 790                 795                 800 
Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr
                805                 810                 815     
Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro
            820                 825                 830         
Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys
        835                 840                 845             
Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His
    850                 855                 860                 
Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile
865                 870                 875                 880 
Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala
                885                 890                 895     
Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu
            900                 905                 910         
His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala
        915                 920                 925             
His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn
    930                 935                 940                 
Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser
945                 950                 955                 960 
Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg
                965                 970                 975     
Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser
            980                 985                 990         
Lys Phe Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile
        995                 1000                1005            
His Ser Ala Asn His Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro
    1010                1015                1020                
Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg
1025                1030                1035               1040 
Gln Ser Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile
                1045                1050                1055    
Glu Asp Glu Ile Lys Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser
            1060                1065                1070        
Thr Thr Tyr Pro Val Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys
        1075                1080                1085            
Phe Gln Pro His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser
    1090                1095                1100                
Arg Gly Ala Asn Gly Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly
1105                1110                1115               1120 
Ile Asn Gln Asn Val Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu
                1125                1130                1135    
Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln
            1140                1145                1150        
His Glu Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu
        1155                1160                1165            
Glu Lys Arg His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala
    1170                1175                1180                
Thr Asp Ile Pro Ser Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser
1185                1190                1195               1200 
Ser Ser Gly Gln Ser Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu
                1205                1210                1215    
Asn Thr Ser Thr Pro Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His
            1220                1225                1230        
Pro Ser Ser Ala Gln Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr
        1235                1240                1245            
Cys Lys Val Ser Ser Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val
    1250                1255                1260                
Glu Asp Thr Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu
1265                1270                1275               1280 
Ser Ser Ala Glu Asp Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala
                1285                1290                1295    
Asp Ser Ala Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly
            1300                1305                1310        
Thr Arg Ser Ala Glu Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln
        1315                1320                1325            
His Pro Arg Thr Lys Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser
    1330                1335                1340                
Glu Ser Ala Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser
1345                1350                1355               1360 
Pro Ser Lys Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr
                1365                1370                1375    
Val Gln Glu Thr Pro Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser
            1380                1385                1390        
Leu Asp Ser Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu
        1395                1400                1405            
Pro Cys Ser Gly Met Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro
    1410                1415                1420                
Asp Ser Pro Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro
1425                1430                1435               1440 
Pro Pro Pro Gln Thr Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys
                1445                1450                1455    
Ala Pro Thr Ala Glu Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val
            1460                1465                1470        
Asn Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu
        1475                1480                1485            
Leu His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser
    1490                1495                1500                
Ser Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val
1505                1510                1515               1520 
Glu Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu
                1525                1530                1535    
Thr Glu Ser Glu Gln Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu
            1540                1545                1550        
Ala Glu Lys Thr Ile Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp
        1555                1560                1565            
Asp Asp Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro
    1570                1575                1580                
Thr Lys Ser Ser Arg Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys
1585                1590                1595               1600 
Leu Pro Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys
                1605                1610                1615    
Leu Leu Pro Ser Gln Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe
            1620                1625                1630        
Thr Pro Gly Asp Asp Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro
        1635                1640                1645            
Ile Asn Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser
    1650                1655                1660                
Pro Pro Asn Glu Leu Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln
1665                1670                1675               1680 
Ser Gly Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser
                1685                1690                1695    
Thr Asp Glu Ala Gln Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu
            1700                1705                1710        
Leu Asp Asp Asn Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile
        1715                1720                1725            
Asn Ser Ala Met Pro Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys
    1730                1735                1740                
Lys Ile Met Asp Gln Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro
1745                1750                1755               1760 
Asn Lys Asn Gln Leu Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val
                1765                1770                1775    
Lys Pro Ile Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn
            1780                1785                1790        
Ala Asp Ser Lys Asn Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn
        1795                1800                1805            
Lys Asp Ser Lys Lys Gln Asn Leu Lys Asn Asn Ser Lys Val Phe Asn
    1810                1815                1820                
Asp Lys Leu Pro Asn Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe
1825                1830                1835               1840 
Asp Ser Pro His His Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe
                1845                1850                1855    
Ser Arg Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val
            1860                1865                1870        
Asp Leu Ser Arg Glu Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys
        1875                1880                1885            
Glu Ser Glu Ala Lys Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln
    1890                1895                1900                
Gln Ser Ala Asn Lys Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg
1905                1910                1915               1920 
Gly Gln Pro Lys Pro Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser
                1925                1930                1935    
Ser Lys Asp Ile Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln
            1940                1945                1950        
Asn Phe Ala Ile Glu Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser
        1955                1960                1965            
Leu Ser Ser Leu Ser Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn
    1970                1975                1980                
Glu Pro Ile Lys Glu Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser
1985                1990                1995               2000 
Lys Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp
                2005                2010                2015    
Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile
            2020                2025                2030        
Asp Ser Glu Asp Asp Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro
        2035                2040                2045            
Lys Lys Lys Lys Pro Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser
    2050                2055                2060                
Pro Arg Asn Met Gly Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu
2065                2070                2075               2080 
Lys Asp Ile Gln Arg Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser
                2085                2090                2095    
Glu Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val
            2100                2105                2110        
Ser Ser Leu His Gln Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala
        2115                2120                2125            
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu
    2130                2135                2140                
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr
2145                2150                2155               2160 
Ser Asn Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu
                2165                2170                2175    
Glu Thr Lys Lys Ile Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys
            2180                2185                2190        
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu
        2195                2200                2205            
Ile Ser Gly Gln Met Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile
    2210                2215                2220                
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser
2225                2230                2235               2240 
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro
                2245                2250                2255    
Ala Ser Lys Ser Pro Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg
            2260                2265                2270        
Gly Ala Lys Pro Ser Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln
        2275                2280                2285            
Thr Ser Gln Ile Gly Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser
    2290                2295                2300                
Arg Asp Ser Thr Pro Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro
2305                2310                2315               2320 
Ile Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile
                2325                2330                2335    
Ser Pro Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser
            2340                2345                2350        
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser
        2355                2360                2365            
Pro Gly Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu
    2370                2375                2380                
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly
2385                2390                2395               2400 
Leu Asn Gln Met Asn Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu
                2405                2410                2415    
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser
            2420                2425                2430        
Glu Arg Pro Val Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro
        2435                2440                2445            
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser
    2450                2455                2460                
Leu Ser Pro Ser Ser Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln
2465                2470                2475               2480 
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His
                2485                2490                2495    
Ser Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser
            2500                2505                2510        
Pro Thr Ile Glu Tyr Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile
        2515                2520                2525            
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser
    2530                2535                2540                
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg
2545                2550                2555               2560 
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala
                2565                2570                2575    
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val
            2580                2585                2590        
Asn Ser Ile Ser Gly Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala
        2595                2600                2605            
Lys Gly Thr Trp Arg Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn
    2610                2615                2620                
Ser Thr Ser Gln Thr Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser
2625                2630                2635               2640 
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp
                2645                2650                2655    
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly
            2660                2665                2670        
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu
        2675                2680                2685            
Lys Ala Asn Pro Asn Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln
    2690                2695                2700                
Asn Val Gly Asn Gly Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn
2705                2710                2715               2720 
Arg Leu Asn Ser Phe Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr
                2725                2730                2735    
Glu Ile Lys Pro Gly Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn
            2740                2745                2750        
Glu Ser Ser Ile Val Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser
        2755                2760                2765            
Lys His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe
    2770                2775                2780                
Asn Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala
2785                2790                2795               2800 
Arg Pro Ser Gln Ile Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg
                2805                2810                2815    
Asp Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys
            2820                2825                2830        
Arg His Ser Gly Ser Tyr Leu Val Thr Ser Val
        2835                2840            

<210> 7
<211> 3834
<212> DNA
<213> Homo sapiens

<400> 7
gaggagagag ggcagcagcg cgcggtgtct ccggctgctc agtccgaccg cggcaagcaa 60
gcgggcaggc gcaccgcccc ctcccccgcc cggcctcccc aactctgcgg ccgcgagtaa 120
agtttgcaaa gaggcgcggg aggcggcagc cgcagcgagg aggcggcggg gaagaagcgc 180
agtctccggg ttgggggcgg gggcgggggg ggcgccaagg agccgggtgg ggggcggcgg 240
ccagcatgcg gccccgcagc gccctgcccc gcctgctgct gccgctgctg ctgctgcccg 300
ccgccgggcc ggcccagttc cacggggaga agggcatctc catcccggac cacggcttct 360
gccagcccat ctccatcccg ctgtgcacgg acatcgccta caaccagacc atcatgccca 420
accttctggg ccacacgaac caggaggacg caggcctaga ggtgcaccag ttctatccgc 480
tggtgaaggt gcagtgctcg cccgaactgc gcttcttcct gtgctccatg tacgcacccg 540
tgtgcaccgt gctggaacag gccatcccgc cgtgccgctc tatctgtgag cgcgcgcgcc 600
agggctgcga agccctcatg aacaagttcg gttttcagtg gcccgagcgc ctgcgctgcg 660
agcacttccc gcgccacggc gccgagcaga tctgcgtcgg ccagaaccac tccgaggacg 720
gagctcccgc gctactcacc accgcgccgc cgccgggact gcagccgggt gccgggggca 780
ccccgggtgg cccgggcggc ggcggcgctc ccccgcgcta cgccacgctg gagcacccct 840
tccactgccc gcgcgtcctc aaggtgccat cctatctcag ctacaagttt ctgggcgagc 900
gtgattgtgc tgcgccctgc gaacctgcgc ggcccgatgg ttccatgttc ttctcacagg 960
aggagacgcg tttcgcgcgc ctctggatcc tcacctggtc ggtgctgtgc tgcgcttcca 1020
ccttcttcac tgtcaccacg tacttggtag acatgcagcg cttccgctac ccagagcggc 1080
ctatcatttt tctgtcgggc tgctacacca tggtgtcggt ggcctacatc gcgggcttcg 1140
tgctccagga gcgcgtggtg tgcaacgagc gcttctccga ggacggttac cgcacggtgg 1200
tgcagggcac caagaaggag ggctgcacca tcctcttcat gatgctctac ttcttcagca 1260
tggccagctc catctggtgg gtcatcctgt cgctcacctg gttcctggca gccggcatga 1320
agtggggcca cgaggccatc gaggccaact ctcagtactt ccacctggcc gcctgggccg 1380
tgccggccgt caagaccatc accatcctgg ccatgggcca gatcgacggc gacctgctga 1440
gcggcgtgtg cttcgtaggc ctcaacagcc tggacccgct gcggggcttc gtgctagcgc 1500
cgctcttcgt gtacctgttc atcggcacgt ccttcctcct ggccggcttc gtgtcgctct 1560
tccgcatccg caccatcatg aagcacgacg gcaccaagac cgaaaagctg gagcggctca 1620
tggtgcgcat cggcgtcttc tccgtgctct acacagtgcc cgccaccatc gtcatcgctt 1680
gctacttcta cgagcaggcc ttccgcgagc actgggagcg ctcgtgggtg agccagcact 1740
gcaagagcct ggccatcccg tgcccggcgc actacacgcc gcgcatgtcg cccgacttca 1800
cggtctacat gatcaaatac ctcatgacgc tcatcgtggg catcacgtcg ggcttctgga 1860
tctggtcggg caagacgctg cactcgtgga ggaagttcta cactcgcctc accaacagcc 1920
gacacggtga gaccaccgtg tgagggacgc ccccaggccg gaaccgcgcg gcgctttcct 1980
ccgcccgggg tggggcccct acagactccg tattttattt ttttaaataa aaaacgatcg 2040
aaaccatttc acttttaggt tgctttttaa aagagaactc tctgcccaac acccccacaa 2100
ggtttgtaat taaaactgta aatagtcttt gtaaatttaa ttatatatat tttctattta 2160
aaagaaaaaa ggagaaaaaa aaacaggggt gtgggcgcca ggactgaaga atgaggtgtg 2220
tgtgtgttgg ggagtgtagt tggggggagg gttctctttc ttaagtgccc ttcaaaaccc 2280
gccccacttt tggagttttt tggtgatatg gcagggctgg gcctgatggg agaggcaccc 2340
agcctgagcg ctgtttttgt tggctttgag tcgttaggag tttgttccat tcaactaata 2400
taaaagccaa atttgtgagc ctcctctctg acgctgggcc tgtggaagcc gttggatatt 2460
tttgaacagg acttggattc gttttgtttc cttccccctt ttctttccct actcatttgt 2520
cctgtcttct tcactcactc ttggaaaagt cccaacagag atgaagacgt ggaaaaaaaa 2580
atcggggtcg gggtgtgctg gtggggagag ggcagagatc cggtgaggaa tggcttccac 2640
cccctggccc attcccctgc aggctggaag atctttctcc tgtctggctt ctcttctttt 2700
caattcgctg caccaagtgc ttccagtggc ccaaaaatgc tttttgaagt gtgttttgaa 2760
acagccccca ccaacataca ccccaccagg agtactgatc ctgcctccct tcatgtctag 2820
gggaagcatt cgcctttgag cacttgtttg caaatctggg gagtttgaga cctcctagca 2880
tctcttccct tctttccctg cagtctattc actcccgcag ccaaaaatct ctggcgttca 2940
ggttagcagt ttctgggttg gtttgtgtgg gtttttgttg ttgtttgggg cttatttttt 3000
tcaaaaagtg ataaagacgg gtgggttgga gggaggggac tgatgggctg gtgggctttt 3060
tagttttcct ttgagaaaaa gactggttta tttaaaattt gtccagaaaa aaatgaaaaa 3120
aaaaaaaaag gtggtatctt tgctttagaa gaagtctctg gataggccct ttgtggctgt 3180
gggggtgggt tgagtgttta cattacattc tatatcacaa gattgatagg atgtttaaag 3240
cagatgtttc ttatcttccc ctgagcccct acaaataaag tcaagacttt tctttttttg 3300
agacggagtc ttgctctgtc gcccaggctg gagtgcagtg gtgcgatctt ggctcactgc 3360
aacctccact gcagcgtttc tcctgcctca gcctcccaag tagctgggac tacaggcgca 3420
cgccaccact ccttgctaat ttttgtattt ttagtagaca cagggtttca ccatattggc 3480
caggctggtc tcgaactcct gacctcgtta tctgcctgcc tcggcctcct aaagtgctgg 3540
gattacagga gtgagccaca gtgcctggcc tgtcaagact tctcttaagt taacttcctg 3600
agaagtgatg tctaaaagta tctttgctgg tgtgagaact ccagtttcca acacatatta 3660
tttccctcaa ctatttggaa tattttagaa ttttaattcc aaaggattag tttgaataca 3720
agtatgccac ataactcagt tttcgccatc ttccatttct taacagtgta aattaaaagc 3780
taataatcat aataataaag tgcatttaat tatctttgaa aaaaaaaaaa aaaa       3834

<210> 8
<211> 565
<212> PRT
<213> Homo sapiens

<400> 8
Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser
            20                  25                  30          
Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr
        35                  40                  45              
Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr
    50                  55                  60                  
Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val
65                  70                  75                  80  
Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr
                85                  90                  95      
Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser
            100                 105                 110         
Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe
        115                 120                 125             
Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His
    130                 135                 140                 
Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala
145                 150                 155                 160 
Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala
                165                 170                 175     
Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr
            180                 185                 190         
Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro
        195                 200                 205             
Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro
    210                 215                 220                 
Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu
225                 230                 235                 240 
Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys
                245                 250                 255     
Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg
            260                 265                 270         
Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr
        275                 280                 285             
Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val
    290                 295                 300                 
Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln
305                 310                 315                 320 
Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe
                325                 330                 335     
Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp
            340                 345                 350         
Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn
        355                 360                 365             
Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr
    370                 375                 380                 
Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly
385                 390                 395                 400 
Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val
                405                 410                 415     
Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu
            420                 425                 430         
Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp
        435                 440                 445             
Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val
    450                 455                 460                 
Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr
465                 470                 475                 480 
Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser
                485                 490                 495     
Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro
            500                 505                 510         
Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr
        515                 520                 525             
Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr
    530                 535                 540                 
Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His
545                 550                 555                 560 
Gly Glu Thr Thr Val
                565 

<210> 9
<211> 8844
<212> DNA
<213> Homo sapiens

<400> 9
ccgcccccgc ccacccggcc ctccgcggcc gcagctcccc ggcggaggca agaggtggtt 60
gggggggacc atggctgacg ttttcccggg caacgactcc acggcgtctc aggacgtggc 120
caaccgcttc gcccgcaaag gggcgctgag gcagaagaac gtgcacgagg tgaaggacca 180
caaattcatc gcgcgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat 240
ctgggggttt gggaaacaag gcttccagtg ccaagtttgc tgttttgtgg tccacaagag 300
gtgccatgaa tttgttactt tttcttgtcc gggtgcggat aagggacccg acactgatga 360
ccccaggagc aagcacaagt tcaaaatcca cacttacgga agccccacct tctgcgatca 420
ctgtgggtca ctgctctatg gacttatcca tcaagggatg aaatgtgaca cctgcgatat 480
gaacgttcac aagcaatgcg tcatcaatgt ccccagcctc tgcggaatgg atcacactga 540
gaagaggggg cggatttacc taaaggctga ggttgctgat gaaaagctcc atgtcacagt 600
acgagatgca aaaaatctaa tccctatgga tccaaacggg ctttcagatc cttatgtgaa 660
gctgaaactt attcctgatc ccaagaatga aagcaagcaa aaaaccaaaa ccatccgctc 720
cacactaaat ccgcagtgga atgagtcctt tacattcaaa ttgaaacctt cagacaaaga 780
ccgacgactg tctgtagaaa tctgggactg ggatcgaaca acaaggaatg acttcatggg 840
atccctttcc tttggagttt cggagctgat gaagatgccg gccagtggat ggtacaagtt 900
gcttaaccaa gaagaaggtg agtactacaa cgtacccatt ccggaagggg acgaggaagg 960
aaacatggaa ctcaggcaga aattcgagaa agccaaactt ggccctgctg gcaacaaagt 1020
catcagtccc tctgaagaca ggaaacaacc ttccaacaac cttgaccgag tgaaactcac 1080
ggacttcaat ttcctcatgg tgttgggaaa ggggagtttt ggaaaggtga tgcttgccga 1140
caggaagggc acagaagaac tgtatgcaat caaaatcctg aagaaggatg tggtgattca 1200
ggatgatgac gtggagtgca ccatggtaga aaagcgagtc ttggccctgc ttgacaaacc 1260
cccgttcttg acgcagctgc actcctgctt ccagacagtg gatcggctgt acttcgtcat 1320
ggaatatgtc aacggtgggg acctcatgta ccacattcag caagtaggaa aatttaagga 1380
accacaagca gtattctatg cggcagagat ttccatcgga ttgttctttc ttcataaaag 1440
aggaatcatt tatagggatc tgaagttaga taacgtcatg ttggattcag aaggacatat 1500
caaaattgct gactttggga tgtgcaagga acacatgatg gatggagtca cgaccaggac 1560
cttctgtggg actccagatt atatcgcccc agagataatc gcttatcagc cgtatggaaa 1620
atctgtggac tggtgggcct atggcgtcct gttgtatgaa atgcttgccg ggcagcctcc 1680
atttgatggt gaagatgaag acgagctatt tcagtctatc atggagcaca acgtttccta 1740
tccaaaatcc ttgtccaagg aggctgtttc tgtctgcaaa ggactgatga ccaaacaccc 1800
agccaagcgg ctgggctgtg ggcctgaggg ggagagggac gtgagagagc atgccttctt 1860
ccggaggatc gactgggaaa aactggagaa cagggagatc cagccaccat tcaagcccaa 1920
agtgactttg tgtaccaaaa tgcactggct tcagtgggcc tccaggtctt cgtgtggcaa 1980
aggagcagag aactttgaca agttcttcac acgaggacag cccgtcttaa caccacctga 2040
tcagctggtt attgctaaca tagaccagtc tgattttgaa gggttctcgt atgtcaaccc 2100
ccagtttgtg caccccatct tacagagtgc agtatgaaac tcaccagcga gaacaaacac 2160
ctccccagcc cccagccctc cccgcagtgg gaagtgaatc cttaacccta aaattttaag 2220
gccacggcct tgtgtctgat tccatatgga ggcctgaaaa ttgtagggtt attagtccaa 2280
atgtgatcaa ctgttcaggg tctctctctt acaaccaaga acattatctt agtggaagat 2340
ggtacgtcat gctcagtgtc cagtttaatt ctgtagaagt tacgtctggc tctaggttaa 2400
cccttcctag aaagcaagca gactgttgcc ccattttggg tacaatttga tatactttcc 2460
ataccctcca tctgtggatt tttcagcatt ggaatccccc aaccagagat gttaaagtga 2520
gcctgtccca ggaaacatct ccacccaaga cgtctttgga atccaagaac aggaagccaa 2580
gagagtgagc agggagggat tgggggtggg ggaggcctca aaataccgac tgcgtccatt 2640
ctctgcctcc atggaaacag cccctagaat ctgaaaggcc gggataaacc taatcactgt 2700
tcccaaacat tgacaaatcc taacccaacc atggtccagc agttaccagt ttaaacaaaa 2760
aaacctcaga tgagtgttgg gtgaatctgt catctggtac cctccttggt tgataactgt 2820
cttgatactt ttcattcttt gtaagaggcc aaatcgtcta aggacgttgc tgaacaagcg 2880
tgtgaaatca tttcagatca aggataagcc agtgtgtaca tatgttcatt ttaatctctg 2940
ggagattatt tttccatcca gggtgccatc agtaatcatg ccactactca ccagtgttgt 3000
tcaccaacac ccacccccac acacaccaac attttgctgc ctaccttgtt atccttctca 3060
agaagctgaa gtgtacgccc tctccccttt tgtgcttatt tatttaatag gctgcagtgt 3120
cgcttatgaa agtacgatgt acagtaactt aatggaagtg ctgactctag catcagcctc 3180
taccgattga ttttcctccc ttctctagcc ctggatgtcc acttagggat aaaaagaata 3240
tggttttggt tcccatttct agttcacgtt gaatgacagg cctggagctg tagaatcagg 3300
aaacccggat gcctaacagc tcaaagatgt tttgttaata gaaggatttt aatacgtttt 3360
gcaaatgcat catgcaatga attttgcatg tttataataa accttaataa caagtgaatc 3420
tatattattg atataatcgt atcaagtata aagagagtat tataataatt ttataagaca 3480
caattgtgct ctatttgtgc aggttcttgt ttctaatcct cttttctaat taagttttag 3540
ctgaatccct tgcttctgtg ctttccctcc ctgcacatgg gcactgtatc agatagatta 3600
ctttttaaat gtagataaaa tttcaaaaat gaatggctag tttacgtgat agattaggct 3660
cttactacat atgtgtgtgt atatatatgt atttgattct acctgcaaac aaatttttat 3720
tggtgaggac tatttttgag ctgacactcc ctcttagttt cttcatgtca cctttcgtcc 3780
tggttcctcc gccactcttc ctcttgggga caacaggaag tgtctgattc cagtctgcct 3840
agtacgttgg tacacacgtg gcattgccgc agcacctggg ctgacctttg tgtgtgcgtg 3900
tgtgtgtgtt tccttcttcc cttcagcctg tgactgttgc tgactccagg ggtgggaggg 3960
atggggagac tcccctcttg ctgtgtgtac tggacacgca ggaagcatgc tgtcttgctg 4020
cctctgcaac gacctgtcgt ttgctccagc atgcacaaac ttcgtgagac caacacagcc 4080
gtgccctgca ggcaccagca cgtgcttttc agaggctgcg gactttcttc cagccattgt 4140
ggcattggcc tttccagtct tgggaggagc gcgctgcttt ggtgagacac ccccatgcaa 4200
ggtcctcaga gtagccgggt tctaccacaa acagaaacag aatgaaagta gctgtcagtc 4260
cttgtagaga gccgctctgt ttcctcccag aagcatctcc cagctaagct cgcattattt 4320
ttctcctctg gctgtttgcc tgaagttcac agaacacaca accatgaaag gctttttgag 4380
gtgagaggcc caggtggtcc tggcaaccct gagtagaagg agagacgggg tagggaacgg 4440
gcccggccag aaaagaacca tttcttctgc catcttttat gcaccataga catcgagact 4500
ccagggggtc ctggctcccc tgtccctgca gccctgcagg tcagtgcatg atctgggttc 4560
gtgtcctgac caggtgctcc tcctttgatc cgaggggaaa gggactggtt tatagaaaga 4620
gcctaggaga caaaagggcc agtccccctg cccagaatgg agcagcagca ggacagaccc 4680
ccacgaggcc ccccagagag gaggaagatc ccacggagga acacatgagg ttagggaccc 4740
ttgttcagca ccccaaacag cctgcctgtt taaagcaggc agcaggctta ggccttccct 4800
gcaaccccaa cacccacaag tttgtttctc taggaaacac attcactgtc tcagctggct 4860
gttactctct cagaccatat ggcaaagttt tccaagaaaa tgccccgaca ggggtgccca 4920
gcacactgcc tgagggacaa cagacatcag aacaaacccc cagagagaaa cagtcaaaat 4980
cagggcccgg tgcagtgttg tcatgtggaa cctgctttat ccattgctga gtgttgaatg 5040
tgggtaatgg ttagggcttt ccagatctca gcagccaaag acagttattg ttggaagact 5100
gtcatgtaga taaccatgag caatggctcg cctcagaatc agttcataaa attctatggt 5160
actggcccct tcgtgggtat tgtgtgaaat gagatggtgg cgaggggtgc gctgtggaac 5220
tgccgcagcc acgcaggagg tccctggggg atgctttggg aagtccttgc ccctgagcac 5280
tgcctgattg ccagggcctg tggaggtcta ggccgcctgg cagaatctag caccgtccga 5340
atccccgcag gacccatgga gctatgacca caccaggcca ttcaaatggc tctgcattat 5400
cttcccttgg aaggtggcca ctcctcggtg gcagggcctt tccctgaggc tgcaggccgt 5460
gggctggcag cccgtctctt ggcatttcaa ttgaaggtca ccaggtgctg ggtttgaaag 5520
gaagtcactg gagtgctgcc aggggccgcc ctccaaggtt aatgagaggc ccacatccag 5580
gcaagaacta attcaaaagg cagatcagaa accacaggag tcaaaattat tgctccggca 5640
gtgcttccct tcctttcatc cactggcctc gtgtggtcca tgcagggcca ctgtctgccc 5700
tttctgatgc cacgtattag gctttcttac tcagaatttt gatagaaaac catggggcca 5760
agagctctgg aagcctggcc ggaaagacca aggttcatgc agcccaacaa atgattgttg 5820
agcacctctc ggagccaaag tccttaggcg agtgtggtga cttcctggaa ggaggatgca 5880
gacttccaga gagccccccc aacggacgtg ctgagaaggg agagggaggc gggggctgta 5940
gtcaggaagg agccagagaa gaacagggtt tgggtgcatc cagaaatatg cctgcagtag 6000
gagggagagg aaggggtgcc accgtcaacg gcttcccatc ggaggtggtt ggtgcagatg 6060
gaagtttctg tctgctggcc ctcaagagag tgttttgcca gggacacagt ctgttcctcc 6120
tcagaaaaca ccccccaaat gctaacaaca tccccaccag ctgctagaag cccctttccc 6180
ctccccacct tgaagtagct catagttctc tgggcagagc cagaccatcc agtgtacccc 6240
agaggccagt aggttcctgc ccattttcct ctctggcttc ctgccaagaa ttatggcagc 6300
tgaggatgaa tggagaagta aaaacaacta acaccgcaca actaacaact aacaccgcag 6360
ttcccacctg ggttccactt agcaggagac atttcggagg gttttttttg tttttgttcc 6420
tgtttttttt ttttttgctg gaatttgttt tctcagtact gaaaagagaa aaagtgacaa 6480
tcttgtattt ttaaaagcct cggaaaggtg ataccatctg acagtcattt tctcacgttg 6540
gtcttctaaa gtcacctatt tcttgtgtgt gcacatcaca ccatttcctg tttctttata 6600
acccgacaag ggtaggagtg cctgtttccc ctgctgggca caccagacaa tcgtaatcac 6660
aaaacagaca ctgagccagg ggcccaaagg gtgtgatcat gagagttacc gggacagcag 6720
taggcatgac agtcaccagg aaggacaagg gtgctctgtt gttagtggcc acacaccaat 6780
ttgacaagga gtgttgcgaa atttttattt atttatttat ttattttgag atggagtttc 6840
actcttgttg cccaggctgg agtgcggtgg tacaatctcg gctcactgca acctccacct 6900
cccaggttca agcgattctc ctgcctcagc ctcccaagta cctgggacta caggtgcgtg 6960
ccaccacacc cagctaaatt ttgtgttttt agtagagatg gggtttcacc atgttggcca 7020
ggatggtctt gaacccctga cctcatgatc tgcctgcctc ggcctcccaa agtgctggga 7080
ttacaggcat gagccaccac gcccagccaa aatatttttt taaagtcatt ttccttaagc 7140
tgcttgggct acatgtgaaa tacactggac ggtcaacatt cctgtctcct cccatttggg 7200
ctgatgcagc agatccaggg aatgttacct gtttctgctg ctagaagatc caggaaattg 7260
ggaaggttac ctgacgcaca catggatgaa ggccatcatc tagaaatggg gtcaaccaca 7320
attgtgttaa ttccgtagtg tcagggattc ttcgggaagg tcaacagtat gaaggattct 7380
gacccctgtg cctcccattt atgtgatcag gtgacagtta ataaccgtgg aggtcacact 7440
cagccatcca acagccttac agtgacccta cacaaaagcc cccaaattcc aaagactttt 7500
tcttaaccta aaggaagaaa ttatttgtta attccagtag agcaactgaa tatactgggc 7560
tatttgtact tttttataga gaactttaat aataattctt taaaaatgag tttttagaac 7620
aaagcaactg acgatttcct aagattccaa tgccctggag cttgtaggag gacttagcct 7680
gggtcagctg gagcaccccc gacctgatct cccactgcca gattttccca tgctcctagg 7740
gtatggagtc cacgtgggaa tgactgcaag ttcaggtgga acttggccga ctgatgctct 7800
gcgagttttt aatagacact ggggacaact gcttaaggtt tagaaacttc caaaccacag 7860
gaaagacatt tttagtgtcc cccatccaga ggcagccctg gaataggatt cccaggggtt 7920
tctgggaccc ctttccttgc tccgtgaggc tctgtggcca tcttttggca ggaggaggat 7980
gcttccttgg ctctgtgccc agacccgcct ggtccccagg tctctcacct tgggtgaaga 8040
ttcagagatg ccctgtaagg attttgccca ctgggcaact cagaaatact tcgatctccc 8100
aagatataag aggcagcagc aaacgtgcct attgacgtct gtttcatagt taccacttac 8160
gcgagtagac agaactcggc ttttcagaaa ataggtgtca agtccacttt ataagaacct 8220
ttttttctaa aataagataa aaggtggctt tgcattttct gattaaacga ctgtgtcttt 8280
gtcacctctg cttaacttta ggagtatcca ttcctgtgat tgtagacttt tgttgatatt 8340
cttcctggaa gaatatcatt cttttcttga agggttggtt tactagaata ttcaaaatca 8400
atcatgaagg cagttactat tttgagtcta aaggttttct aaaaattaac ctcacatccc 8460
ttctgttagg gtctttcaga atatctttta taaacagaag catttgaagt cattgctttt 8520
gctacatgat ttgtgtgtgt gaaggacata ccacgtttaa atcattaatt gaaaaacatc 8580
atataagccc caactttgtt tggaggaaga gacggaggtt gaggtttttc cttctgtata 8640
agcacctact gacaaaatgt agaggccatt caaccgtcaa acaccatttg gttatatcgc 8700
agaggagacg gatgtgtaaa ttactgcatt gctttttttt tcagtttgta taacctctaa 8760
tctccgtttg catgatacgc tttgttagaa acattaattg tagtttggaa gcaagtgtgt 8820
atgaataaag ataatgatca ttcc                                        8844


<210> 10
<211> 688
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val
 1               5                  10                  15      
Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His
            20                  25                  30          
Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr
        35                  40                  45              
Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly
    50                  55                  60                  
Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu
65                  70                  75                  80  
Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp
                85                  90                  95      
Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro
            100                 105                 110         
Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln
        115                 120                 125             
Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val
    130                 135                 140                 
Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly
145                 150                 155                 160 
Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr
                165                 170                 175     
Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser
            180                 185                 190         
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser
        195                 200                 205             
Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn
    210                 215                 220                 
Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu
225                 230                 235                 240 
Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met
                245                 250                 255     
Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser
            260                 265                 270         
Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val
        275                 280                 285             
Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys
    290                 295                 300                 
Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro
305                 310                 315                 320 
Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu
                325                 330                 335     
Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys
            340                 345                 350         
Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys
        355                 360                 365             
Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr
    370                 375                 380                 
Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu
385                 390                 395                 400 
Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val
                405                 410                 415     
Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val
            420                 425                 430         
Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser
        435                 440                 445             
Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu
    450                 455                 460                 
Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala
465                 470                 475                 480 
Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg
                485                 490                 495     
Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr
            500                 505                 510         
Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu
        515                 520                 525             
Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp
    530                 535                 540                 
Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser
545                 550                 555                 560 
Leu Ser Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His
                565                 570                 575     
Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg
            580                 585                 590         
Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg
        595                 600                 605             
Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Thr Leu Cys Thr Lys Met
    610                 615                 620                 
His Trp Leu Gln Trp Ala Ser Arg Ser Ser Cys Gly Lys Gly Ala Glu
625                 630                 635                 640 
Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro
                645                 650                 655     
Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe
            660                 665                 670         
Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val
        675                 680                 685             

<210> 11
<211> 10974
<212> DNA
<213> Homo sapiens

<400> 11
gattcacagg gcctctgagc attatccccc atactcctcc ccatcattct ccacccagct 60
gttggagcca tctgtctgat caccttggac tccatagtac actggggcaa agcacagccc 120
cagtttctgg aggcagatgg gtaaccagga aaaggcatga atgagggggc cccaggagac 180
agtgacttag agactgaggc aagagtgccg tggtcaatca tgggtcattg tcttcgaact 240
ggacaggcca gaatgtctgc cacacccaca cctgcaggtg aaggagccag aagctcttca 300
acctgtagct ccctgagcag gctgttctgg tctcaacttg agcacataaa ctgggatgga 360
gccacagcca agaactttat taatttaagg gagttcttct cttttctgct ccctgcattg 420
agaaaagctc aaattgaaat tattccatgc aagatctgtg gagacaaatc atcaggaatc 480
cattatggtg tcattacatg tgaaggctgc aagggctttt tcaggagaag tcagcaaagc 540
aatgccacct actcctgtcc tcgtcagaag aactgtttga ttgatcgaac cagtagaaac 600
cgctgccaac actgtcgatt acagaaatgc cttgccgtag ggatgtctcg agatgctgta 660
aaatttggcc gaatgtcaaa aaagcagaga gacagcttgt atgcagaagt acagaaacac 720
cggatgcagc agcagcagcg cgaccaccag cagcagcctg gagaggctga gccgctgacg 780
cccacctaca acatctcggc caacgggctg acggaacttc acgacgacct cagtaactac 840
attgacgggc acacccctga ggggagtaag gcagactccg ccgtcagcag cttctacctg 900
gacatacagc cttccccaga ccagtcaggt cttgatatca atggaatcaa accagaacca 960
atatgtgact acacaccagc atcaggcttc tttccctact gttcgttcac caacggcgag 1020
acttccccaa ctgtgtccat ggcagaatta gaacaccttg cacagaatat atctaaatcg 1080
catctggaaa cctgccaata cttgagagaa gagctccagc agataacgtg gcagaccttt 1140
ttacaggaag aaattgagaa ctatcaaaac aagcagcggg aggtgatgtg gcaattgtgt 1200
gccatcaaaa ttacagaagc tatacagtat gtggtggagt ttgccaaacg cattgatgga 1260
tttatggaac tgtgtcaaaa tgatcaaatt gtgcttctaa aagcaggttc tctagaggtg 1320
gtgtttatca gaatgtgccg tgcctttgac tctcagaaca acaccgtgta ctttgatggg 1380
aagtatgcca gccccgacgt cttcaaatcc ttaggttgtg aagactttat tagctttgtg 1440
tttgaatttg gaaagagttt atgttctatg cacctgactg aagatgaaat tgcattattt 1500
tctgcatttg tactgatgtc agcagatcgc tcatggctgc aagaaaaggt aaaaattgaa 1560
aaactgcaac agaaaattca gctagctctt caacacgtcc tacagaagaa tcaccgagaa 1620
gatggaatac taacaaagtt aatatgcaag gtgtctacat taagagcctt atgtggacga 1680
catacagaaa agctaatggc atttaaagca atatacccag acattgtgcg acttcatttt 1740
cctccattat acaaggagtt gttcacttca gaatttgagc cagcaatgca aattgatggg 1800
taaatgttat cacctaagca cttctagaat gtctgaagta caaacatgaa aaacaaacaa 1860
aaaaattaac cgagacactt tatatggccc tgcacagacc tggagcgcca cacactgcac 1920
atcttttggt gatcggggtc aggcaaagga ggggaaacaa tgaaaacaaa taaaagttga 1980
acttgttttt ctcatgcata tgatttccat tatgcctaca gatatggacc ctttttctgt 2040
cttgacttct tgatcattga cctctgttta caacaggagg agggtactaa agtcggagga 2100
tttccttttc ttgtagctca ctgcccacag actttctaca gagtcaccaa tctgtcagta 2160
acaacagaga gtccagcaat aatcggtgac tggtgtgcat agcggaggtt gcggcattac 2220
tttgcacaac tagctctttg tttcatgaag gaagttttta ttttttcacc gattattgcc 2280
agtccgcagg atggcatgaa aagggtccat agcagtagca acaatagcat tataatatat 2340
tacagggtaa atgggcatga agactatata tagctaaaag agatattgtt tatatattgt 2400
tttaagtaat ataaaatgta gttactggtg tagcttttcc tgttgaattg ataaggcact 2460
ttcattttgc acctttttct ttaaattaaa tgctagcgtg ttcactgtcg tgtcgcatgt 2520
gcaccagaaa cacaagttta actgagaagg cttggaaggt acgttgggag gtatttatgc 2580
tgctgtttac aaaattattt ttaagagact ggctggtcat atctagaaat caccacgttg 2640
gatttttttt ttaacatgtg aatttggaat tagaaacgga actctcccta aattatactt 2700
tgctttttgg taagtttaat gatagatgtg tttatgcttc atacaaagtt gaatgattga 2760
ttggcgtggt ggacatatac catcatgctc attttttttt tttaaagctt tttaaaatgc 2820
cacctcatgg aggcgagggg gaggagaagc tcattttaca caattcagta gttaaatatg 2880
gactcggtct caacttggaa ttcttatgct ttgagaacaa atcaacaacc agaatattta 2940
ttggaatcta gcttttatta taagaaggac ccaaagatta tatcctgagc aaatgcacac 3000
tccccatgtg aggacatgaa gtatttactt tgtgaatgtt tatgttcttg gtataatcta 3060
ggaaccctat gagtttatct cagagtgaac taattctaga tttgttgtca atagatgcta 3120
taattcaaga atgttgctct ccatatttga aaaacgatgg ataggagggt gagggaagca 3180
tacaatgttg aaccagtttc tcttatttaa atattaaata ctttaagcct ttaaagtgaa 3240
gttgatgcta gctgcaaaca tttactcttg tatttatctt cactaggaaa ctgtggactg 3300
taatttattt tattaaatat ttagaagatt atttggcttg tgtgttcagg tgagaaatac 3360
tgagttgttt ttgtttaatt tcatggtttt ttttttttta atgatcccta gtgggggaag 3420
gggaaaggaa tagtctgata aacagatgtg catattttaa aaacaagtga ccttttggga 3480
atgtaggcat ttagacgatg attttagtcg cactaggggt gggattcaaa ctactggtca 3540
aagaccattt tgtacagaaa agggaacatc tccgatgggt gttaaggtag gagtttccat 3600
gcagcccttt atgtctgaga aatagtctcc tctgccattg gggtccctgc ggaatcttct 3660
acaggaattg cagctcttca cgtcatgcta ggttaccagc atgggcttcc cagagcactt 3720
cactctgttt ctaactccac tgacttttct gacttgtttc ttgagggact tggaaaaggg 3780
gaaggtatta ttcacacaga tgtgtgtatg aagcctaaat aacatccaac tttttttcca 3840
aaaacatagt aagagtttaa ccataaatag aagagtaata ttcctttaaa tttcttacag 3900
gcatgtaaaa ttttatgtgt ttatagagag atgctaactg tcagcatata gtatttatat 3960
tggggcaaga agggttaaat caaatcttta atttaagtaa gcatagttcc tttaaagatc 4020
agtagtattt atactctgaa aagagtacca agcttagttc agttatttat tcatccattt 4080
tttttctatt gtttctcctc tggggggaaa tggtgttttg tttttgtttg agttttgtgt 4140
tttagttttt tggttttggt tttgttttgt ttttttgtca ttcagattca ctaaatttgg 4200
ggatggtttt attaaagtat attaacttct ttttaaccaa agctttctga atatgaccag 4260
cctcaggtgc tagcgcatta aagagcaact aaacctaatt ccagtgtcga tttgtgaaat 4320
aataaaagct aattgaattt ctctaagggt gagagagaac ataatgatga acttaaaaag 4380
aaattccttt tcccagaagg gattctgcat gtacctacaa acaatcatgc tctaaccaca 4440
gtaatagtca tgccatggtg acattgcttt tacggtaaac caagataggt aatatgatgc 4500
ttcttcccag gtgtttctga aagaaaagca gcggtggagc ttaagagcca agtccactga 4560
ttgacataat aggatggaat tgtagacaga gacatgctcc atgaaacaag gaaacaactg 4620
actactattt ggatctaagt tgggatctga tgttaaacaa taaattcagt ttaaaaaaaa 4680
tatggagctc agaaaaggat gtgaaaaact ttgcattttc ctttcttcat tattacaaaa 4740
acacctatgt gatgacataa aatacttggg tgatatcaga acaattatcc ttaatagttt 4800
ttataattaa agtttcctaa acttcagtct ccaatagtct tttaaggatt ggaaccacat 4860
cactgtcagc cccgctgcta caatgccttt gtacaatttt tttacataag gcaaataagg 4920
cttttgtaca aagcctgaat accttctgtt ccaatggtgt ccaaatggtt attatattgt 4980
gaaaaacctg gccttggtca caatgcaaac aaaagtacag atgaaagtgc tttttggaca 5040
gtttgcaaat tgtgttaaag ctacggattt tttttaaagt gttcagcatc ttaacgtgta 5100
ttaaagctat ggattttttt ttaaagtctt cagcatccta attcaccctt tctaacttaa 5160
gaaaaacatg acttaagaca ctgcttctaa gtttggttgt tctttatagt gtggataccc 5220
agttatctgt gagcgtatgg gggtgggctg agggtcaggt gaggaaggag tgtgtgtgtg 5280
tgtgtgtgtg tgtgtgtgtg tgtgtgtgat ttgcatgtgt atgatgtgtg tgcgtcggac 5340
cgcttctagg ctactaagtg tcaatggaaa agaaaatgta ttcaaaatac ttaaatcaaa 5400
actagaagat ggggaaaaaa agatttattc tatacaaagc cttgtctgga ccactttaga 5460
gagacttcta tttttttaac ccttctataa atatttgatg gcacttgaaa tattcctgca 5520
ataaaatgtg atttgtgtaa agaaaaaaag attttgtaat gtgaaacaaa gaaagaaagt 5580
aatgtaattt tctaaaaaaa aaaatacaaa caaacaaact ttgtattatt ttcttgatgg 5640
aatttgtcta tctgtctttg gaaaactttt tatttcattg aatgtgccat agtagaaatg 5700
tgtgttttta gttttagact aaggaatagc tagttgttgt gttccgacat tccaaaatgc 5760
aaaacaacct agtagtatct ttcatgaaaa ggtttaagta gtatgtaagc ttctctcatt 5820
gttgcttttt tgcacatgtt cttcattcct ctctagtgca atatgtacat agagcacttg 5880
cgggtgtacc ttgatccctc agggaaaaat acatatttgt acagtttttt ggggtttttt 5940
tgttttttgg ttttttttgt tttgcctttt gtttttggct aaggaatgtc gatcgaatca 6000
cttgttattg ttgaggggca gccagataat aatcctaaag ccactgtttc caacattgat 6060
tgtttaaatc atatgtcctt ccaatgctat tattttaaga taataataaa aagttatttt 6120
ctgacagttc tttgtgctga ctggtgaaaa acaagggtaa ataagcacct tataattgac 6180
ttactgtgaa tgacaatcca tcttggtatc aacgatagaa gccctatcat tttggagttg 6240
gggttaagag tcagaaacaa tgtgctcagg gatctcctaa aactcttaaa acagggtggc 6300
cagtactact gggacaaatt gtgtttttta ttattaataa taatgataat aatactatcc 6360
ctccaaggca caagtgaact atatagaact gcgtgtgtgt aaactcttta ctctcgtctc 6420
attttgttga gtttagaact tgatgtgctc gtcagtcttg tgtttcaaaa cactgaataa 6480
cttccaaagc aaagttatgc cagtgtgttc aaaagataaa ttaataatgt accagcaaag 6540
agcatcattc aaagtatagt ccttgcatat tccagttacc atttctctaa taattaaaat 6600
attcatgata aatatatata tagcatcata tgttaaaaac tatttcaaat tctacatatt 6660
aaggatgaaa attttaaaat ccagtaataa gaggagagac ctgcctatca gtacagtgat 6720
ataggtaaaa gatgaaatat gtttttaaaa taccagcaat taactattgt tttcatgggt 6780
tctcctctag aagcaaacca aaaattcctt catggaaaac aattcttact tctacatgtg 6840
tagtttatat ctgatgcatt acaagagcta atgtttaaag acaaaacaaa acctgcctgt 6900
atgacagcag caactcgagc caacatttag tgttacatgt tatatttttg aaataccgtt 6960
ttgttatcat attccacata ttactttcca taaagtcaga gaagttcaat gtaattgttg 7020
gctctgattc ttccaccttg ggatacacat tcacaagaag atttatatat tttcttacta 7080
tgatagagga acataatctg ggaaaacttc ccatgtctgt aagatgaaaa ggataccttt 7140
accatgttgt ttttgataat aaagaatatg gaaaatggta gaaatctctc ctctctatgt 7200
gtatttgtat atgtgtgtat acacacacac gttgacattt ttacataaca tgtgattgcc 7260
acttcttata aagttatgat atagaacccc atgaaaacaa ctttatatta tagatcaaat 7320
aatgtgccca gaaacgcaat tgcaacagta aatcttgatc tattggtaag agtctatgat 7380
acaggtcttc attctatccc taaacataat gttagtaaag aggttccatc agattgtatt 7440
atagagacct tcctattgct atttattttt aagagatgag aagactgact agcaatgtct 7500
ccacagtgca attggtttca cttctgggtc tgtctgtctg tttgtgtagg tgagatcagt 7560
gttgtcaggc tctcagaata atttttaaaa gaatccagaa gcctgacttc acaccaagta 7620
gccatcctag atgggcgggg gggatctcca tgttcaacca aaccctcaga acttagagca 7680
ataaatacat tcagtcattt atttataaat gaatgacaga atattcaatc caaatagaaa 7740
caaccttttg tcagtgatgc aacataacat ggagtcttat attgagaaag tgaatatgaa 7800
tattttaaat agatgcctag gaaatctgtg tttgctgttt acatttaatg tactttgcca 7860
cattagcagt accacacttc ttttactttc atccttctaa gaactaatga aagatagctt 7920
gctattagct ttgacatgtt gcacatgcca ttatgttgtt ctctaagaac aactaaattc 7980
tctccagtgt tcatgtgtga ttcctttttc atcattatta ctttaatgtg gatgaatact 8040
atttctagga acttgattat cactgaacag attgcatatg taaatgcaga taattcttga 8100
gcaatatagt gaaaatgatt tcacaaaaaa aatccatatg tactgtatac atcttcctga 8160
atccaaaatt ctcctgttat ccacacagtt tgaaatctca tattaaacag tggtaaattt 8220
ttaaacatta ggacattagc tggctgcttc tataaatgta cctgtattgt ctgcctgctc 8280
cttttgtgga gatgtgtttt tgtattggat gtttgggcca atgggaggct tcaagctaca 8340
acatattttc ccactttaaa taatatttaa catatgacaa accccagaca aggcttttaa 8400
tatgtataaa gaactgcagt gttaggtggt ttatttgcaa actgttttca gtgttgtcca 8460
tttttatggc acctttaaca atattcttgt ttccaaagta caaaaaaaat aggttaaata 8520
atctagccat aactgaatgt caagcaataa aacaaatgac ttttgtgcat agacttaaaa 8580
aatacaaatt ttagacatct gcatgtaaat gcaatctctt gtttactgct ttcttcaact 8640
tgagcaatcg attccttatt tactattaac ttaagaactt gtaacggcct gtaaacattt 8700
tctctcttac tcttctttca aatttacctg tccctgcttt tgagtcataa tatttaatgt 8760
tgttctgcac atctctatac agttaacttt ttggctttca ttctgtatag ataagaaaat 8820
gttatattat aaacagccta ctcagtgcaa atatttatct gtttatcaaa tccacaatat 8880
gctgtataat accggtttta ctatataatc tattttagac atagctgttt agaactagag 8940
tgtgctattt ttgtgttttt ctgatgtgtg gtgctagaca agttactttt gtgaacaaca 9000
aaaattatcc cttttattcc tagacaatac cacctttggg tcttgttaat ttcactgagt 9060
ataactatat atttgtatat atatacatat atatatatat ctacctatgc ccaactggca 9120
gctgtatcag agtgctggat ttgggacatg cttttctctt taaatacata atatcattat 9180
ataaattatt ctagagtgta tttaattagg ataaaattac ttccttagta tggatatttg 9240
acatctatag ggtgaatttg tttataaata tggctatatg gaaacttatt agcatttact 9300
ttatgtttgc tacttggctt tacagcatat ctcctaagct gaaaaataat ttgccaggcc 9360
ttcaagatcc taaagaaact tgtttaatgg agtaatatac ttttttttct tattaaggaa 9420
ttgtattact ggcacctaac acagttgtat tcttagctcc tattatagat aatgggcatt 9480
tacataaaat atcctagatg gcttgatggc agaataaacc tttcccctcc tacctgagtc 9540
atgagaagga tggagacgtc ctctgccata acatgggcca taaagcaaat tcgacatggg 9600
atgttctgtt tcagtatgac ctcaaccagt tccatgaact gagtgaagga ccttcatttt 9660
caaagttatt taataagtag cttaattaag cctttctacc cattctccca agatctactg 9720
gcattattga aaagcaaagt ttatcaaata tctaactaag gatgtagtta accttattaa 9780
atattgatta gaattgttct gtaatattac tgaatttgta agatctttag caaagatttt 9840
tgagcaattt ataaatgtag agcaaatgtt tctgtttact gcactttttg taactgaagg 9900
tgataaattc tcaagccatg attattggct tccatgcact gcaatattta tccacaattc 9960
tagacatttt ccatttttgt ggaagagttg ctgttacctt aattataaat gcaattgtgt 10020
ggttaatgag agctaatgct agtagttaac cttttaaagt ggattggcta cagttgaggg 10080
agaaatctct tttaatataa atcacatcat tccttaactg cctctcttgg aaagagattg 10140
aaaccttttt tttaaagcac gatttagcat cctaagcttc ctgagggtag agattgtatc 10200
tttttgcgtc tgcacaatgg ctagcacatg tcagcatttg acaattgtta aatgataaca 10260
agtgtgcccc aattaaaacg tttttcctgg gttgttttgt taaatttaca aagtaagcca 10320
agccttacgg ttaacattct cctctacaac caagtattaa agccacattt aaaaagacca 10380
catgaaatgc tgattctaat tgtgtgtagg tcttgaggat taagcacaca aatttcacaa 10440
acttctgttt gagtaaacaa actcagcctt ctgtaaatat acatgcaagt ttggaaacag 10500
taatactgta cctataaata tatgctgtct gttttgtgta cagtatgtaa aaactccttt 10560
tctgccacac taaaaatgca agccatttat gggaatccta aaactagtat tgaactaaaa 10620
ctttgctaat gatctttatt agaggatcgt ccaacttttc acttaccttg ggttttcttt 10680
tcaattcact cttacactag tctgcttatt tccagctgtt tattttattg agtcctgaat 10740
ttaaaaaaaa aatattttga ttcattttgt aaatacaagc tgtacaaaaa agagagattt 10800
aatgttgtct tttaaatact ccaattttca ttctaatatg aatgttgtta tattgtactt 10860
agaaactgta cctttaatat tacattacct ttattaaaag tgcattgaac acatcaattt 10920
tagatgtgct ttatgtactg ttatcctata ataaaacttc agcttctaat ggaa       10974


<210> 12
<211> 548
<212> PRT
<213> Homo sapiens

<400> 12
Met Asn Glu Gly Ala Pro Gly Asp Ser Asp Leu Glu Thr Glu Ala Arg
 1               5                  10                  15      
Val Pro Trp Ser Ile Met Gly His Cys Leu Arg Thr Gly Gln Ala Arg
            20                  25                  30          
Met Ser Ala Thr Pro Thr Pro Ala Gly Glu Gly Ala Arg Ser Ser Ser
        35                  40                  45              
Thr Cys Ser Ser Leu Ser Arg Leu Phe Trp Ser Gln Leu Glu His Ile
    50                  55                  60                  
Asn Trp Asp Gly Ala Thr Ala Lys Asn Phe Ile Asn Leu Arg Glu Phe
65                  70                  75                  80  
Phe Ser Phe Leu Leu Pro Ala Leu Arg Lys Ala Gln Ile Glu Ile Ile
                85                  90                  95      
Pro Cys Lys Ile Cys Gly Asp Lys Ser Ser Gly Ile His Tyr Gly Val
            100                 105                 110         
Ile Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Gln Gln Ser
        115                 120                 125             
Asn Ala Thr Tyr Ser Cys Pro Arg Gln Lys Asn Cys Leu Ile Asp Arg
    130                 135                 140                 
Thr Ser Arg Asn Arg Cys Gln His Cys Arg Leu Gln Lys Cys Leu Ala
145                 150                 155                 160 
Val Gly Met Ser Arg Asp Ala Val Lys Phe Gly Arg Met Ser Lys Lys
                165                 170                 175     
Gln Arg Asp Ser Leu Tyr Ala Glu Val Gln Lys His Arg Met Gln Gln
            180                 185                 190         
Gln Gln Arg Asp His Gln Gln Gln Pro Gly Glu Ala Glu Pro Leu Thr
        195                 200                 205             
Pro Thr Tyr Asn Ile Ser Ala Asn Gly Leu Thr Glu Leu His Asp Asp
    210                 215                 220                 
Leu Ser Asn Tyr Ile Asp Gly His Thr Pro Glu Gly Ser Lys Ala Asp
225                 230                 235                 240 
Ser Ala Val Ser Ser Phe Tyr Leu Asp Ile Gln Pro Ser Pro Asp Gln
                245                 250                 255     
Ser Gly Leu Asp Ile Asn Gly Ile Lys Pro Glu Pro Ile Cys Asp Tyr
            260                 265                 270         
Thr Pro Ala Ser Gly Phe Phe Pro Tyr Cys Ser Phe Thr Asn Gly Glu
        275                 280                 285             
Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala Gln Asn
    290                 295                 300                 
Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu
305                 310                 315                 320 
Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr
                325                 330                 335     
Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile Lys Ile
            340                 345                 350         
Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile Asp Gly
        355                 360                 365             
Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly
    370                 375                 380                 
Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp Ser Gln
385                 390                 395                 400 
Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe
                405                 410                 415     
Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu Phe Gly
            420                 425                 430         
Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala Leu Phe
        435                 440                 445             
Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys
    450                 455                 460                 
Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu Gln His
465                 470                 475                 480 
Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile
                485                 490                 495     
Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr Glu Lys
            500                 505                 510         
Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu His Phe
        515                 520                 525             
Pro Pro Leu Tyr Lys Glu Leu Phe Thr Ser Glu Phe Glu Pro Ala Met
    530                 535                 540                 
Gln Ile Asp Gly
545             

<210> 13
<211> 3818
<212> DNA
<213> Homo sapiens

<400> 13
ctccccggta aagtctcgcg gtgctgccgg gctcagcccc gtctcctcct cttgctccct 60
cggccgggcg gcggtgactg tgcaccgacg tcggcgcggg ctgcaccgcc gcgtccgccc 120
gcccgccagc atggccacca ccgccacctg cacccgtttc accgacgact accagctctt 180
cgaggagctt ggcaagggtg ctttctctgt ggtccgcagg tgtgtgaaga aaacctccac 240
gcaggagtac gcagcaaaaa tcatcaatac caagaagttg tctgcccggg atcaccagaa 300
actagaacgt gaggctcgga tatgtcgact tctgaaacat ccaaacatcg tgcgcctcca 360
tgacagtatt tctgaagaag ggtttcacta cctcgtgttt gaccttgtta ccggcgggga 420
gctgtttgaa gacattgtgg ccagagagta ctacagtgaa gcagatgcca gccactgtat 480
acatcagatt ctggagagtg ttaaccacat ccaccagcat gacatcgtcc acagggacct 540
gaagcctgag aacctgctgc tggcgagtaa atgcaagggt gccgccgtca agctggctga 600
ttttggccta gccatcgaag tacagggaga gcagcaggct tggtttggtt ttgctggcac 660
cccaggttac ttgtcccctg aggtcttgag gaaagatccc tatggaaaac ctgtggatat 720
ctgggcctgc ggggtcatcc tgtatatcct cctggtgggc tatcctccct tctgggatga 780
ggatcagcac aagctgtatc agcagatcaa ggctggagcc tatgatttcc catcaccaga 840
atgggacacg gtaactcctg aagccaagaa cttgatcaac cagatgctga ccataaaccc 900
agcaaagcgc atcacggctg accaggctct caagcacccg tgggtctgtc aacgatccac 960
ggtggcatcc atgatgcatc gtcaggagac tgtggagtgt ttgcgcaagt tcaatgcccg 1020
gagaaaactg aagggtgcca tcctcacgac catgcttgtc tccaggaact tctcagctgc 1080
caaaagccta ttgaacaaga agtcggatgg cggtgtcaag ccacagagca acaacaaaaa 1140
cagtctcgta agcccagccc aagagcccgc gcccttgcag acggccatgg agccacaaac 1200
cactgtggta cacaacgcta cagatgggat caagggctcc acagagagct gcaacaccac 1260
cacagaagat gaggacctca aagctgcccc gctccgcact gggaatggca gctcggtgcc 1320
tgaaggacgg agctcccggg acagaacagc cccctctgca ggcatgcagc cccagccttc 1380
tctctgctcc tcagccatgc gaaaacagga gatcattaag attacagaac agctgattga 1440
agccatcaac aatggggact ttgaggccta cacgaagatt tgtgatccag gcctcacttc 1500
ctttgagcct gaggcccttg gtaacctcgt ggaggggatg gatttccata agttttactt 1560
tgagaatctc ctgtccaaga acagcaagcc tatccatacc accatcctaa acccacacgt 1620
ccacgtgatt ggggaggacg cagcgtgcat cgcctacatc cgcctcaccc agtacatcga 1680
cgggcagggt cggcctcgca ccagccagtc agaagagacc cgggtctggc accgtcggga 1740
tggcaagtgg ctcaatgtcc actatcactg ctcaggggcc cctgccgcac cgctgcagtg 1800
agctcagcca caggggcttt aggagattcc agccggaggt ccaaccttcg cagccagtgg 1860
ctctggaggg cctgagtgac agcggcagtc ctgtttgttt gaggtttaaa acaattcaat 1920
tacaaaagcg gcagcagcca atgcacgccc ctgcatgcag ccctcccgcc cgcccttcgt 1980
gtctgtctct gctgtaccga ggtgtttttt acatttaaga aaaaaaaaaa agaaaaaaag 2040
attgtttaaa aaaaaaagga atccatacca tgatgcgttt taaaaccacc gacagccctt 2100
gggttggcaa gaaggcagga gtatgtatga ggtccatcct ggcatgagca gtggctcacc 2160
caccggcctt gaagaggtga gcttggcctc tctggtcccc atggacttag ggggaccagg 2220
caagaactct gacagagctt tgggggccgt gatgtgattg cagctcctga ggtggcctgc 2280
ttaccccagg tctaggaatg aacttctttg gaacttgcat aggcgcctag aatggggctg 2340
atgagaacat cgtgaccatc agacctactt gggagagaac gcagagctcc cagcctgctg 2400
tggaggcagc tgagaagtgg tggcctcagg actgagagcc cggacgttgc tgtactgtct 2460
tgtttagtgt agaagggaag agaattggtg ctgcagaagt gtacccgcca tgaagccgat 2520
gagaaacctc gtgttagtct gacatgcact cactcatcca tttctatagg atgcacaatg 2580
catgtgggcc ctaatattga ggccttatcc ctgcagctag gagggggagg ggttgttgct 2640
gctttgcttc gtgttttctt ctaacctggc aaggagagag ccaggccctg gtcagggctc 2700
ccgtgccgcc tttggcggtt ctgtttctgt gctgatctgg accatctttg tcttgccttt 2760
tcacggtagt ggtccccatg ctgaccctca tctgggcctg ggccctctgc caagtgcccc 2820
tgtgggatgg gaggagtgag gcagtgggag aagaggtggt ggtcgtttct atgcattcag 2880
gctgcctttg gggctgcctc ccttcttatt cttccttgct gcacgtccat ctcttttcct 2940
gtctttgaga ttgacctgac tgctctggca agaagaagag gtgtccttac agaggcctct 3000
ttactgacca actgaagtat agacttactg ctggacaatc tgcatgggca tcacccctcc 3060
ccgcatgtaa cccaaaagag gtgtccagag ccaaggcttc taccttcatt gtccctctct 3120
gtgctcaagg agttccattc caggaggaag agatctatac cctaagcaga tagcaaagaa 3180
gataatggag gagcaattgg tcatggcctt ggtttccctc aaaacaacgc tgcagattta 3240
tctgcacaaa catctccact tttgggggaa aggtgggtag attccagttc cctggactac 3300
cttcaggagg cacgagagct gggagaagag gcaaagctac aggtttactt gggagccagc 3360
tgagaagaga gcagactcac aggtgctggt gcttggattt agccaggctc ctccgagcac 3420
ctcatgcatg tcccagcccc tgggccctag ccctttcctg ccctgcagtc tgcagtgcca 3480
gcacgcaaat cccttcacca cagggtttcg ttttgctggc ttgaagacaa atggtcttag 3540
aattcattga gacccatagc ttcatatggc tgctccagcc ccacttctta gcattcttac 3600
tcctcttctg gggctaatgt cagcatctat agacaataga ctattaaaaa atcacctttt 3660
aaacaagaaa cggaaggcat ttgatgcaga atttttgcat gacaacatag aaataattta 3720
aaaatagtgt ttgttctgaa tgttggtaga cccttcatag ctttgttaca atgaaacctt 3780
gaactgaaaa tatttaataa aataaccttt aaacagtc                         3818

<210> 14
<211> 556
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His
        115                 120                 125             
Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Pro Gln Ser Asn Asn Lys
                325                 330                 335     
Asn Ser Leu Val Ser Pro Ala Gln Glu Pro Ala Pro Leu Gln Thr Ala
            340                 345                 350         
Met Glu Pro Gln Thr Thr Val Val His Asn Ala Thr Asp Gly Ile Lys
        355                 360                 365             
Gly Ser Thr Glu Ser Cys Asn Thr Thr Thr Glu Asp Glu Asp Leu Lys
    370                 375                 380                 
Ala Ala Pro Leu Arg Thr Gly Asn Gly Ser Ser Val Pro Glu Gly Arg
385                 390                 395                 400 
Ser Ser Arg Asp Arg Thr Ala Pro Ser Ala Gly Met Gln Pro Gln Pro
                405                 410                 415     
Ser Leu Cys Ser Ser Ala Met Arg Lys Gln Glu Ile Ile Lys Ile Thr
            420                 425                 430         
Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr
        435                 440                 445             
Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly
    450                 455                 460                 
Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe Glu Asn Leu
465                 470                 475                 480 
Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His
                485                 490                 495     
Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu
            500                 505                 510         
Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu
        515                 520                 525             
Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu Asn Val His
    530                 535                 540                 
Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln
545                 550                 555     

<210> 15
<211> 3338
<212> DNA
<213> Homo sapiens

<400> 15
gacatcatgg gctattttta ggggttgact ggtagcagat aagtgttgag ctcgggctgg 60
ataagggctc agagttgcac tgagtgtggc tgaagcagcg aggcgggagt ggaggtgcgc 120
ggagtcaggc agacagacag acacagccag ccagccaggt cggcagtata gtccgaactg 180
caaatcttat tttcttttca ccttctctct aactgcccag agctagcgcc tgtggctccc 240
gggctggtgt ttcgggagtg tccagagagc ctggtctcca gccgcccccg ggaggagagc 300
cctgctgccc aggcgctgtt gacagcggcg gaaagcagcg gtacccacgc gcccgccggg 360
ggaagtcggc gagcggctgc agcagcaaag aactttcccg gctgggagga ccggagacaa 420
gtggcagagt cccggagcga acttttgcaa gcctttcctg cgtcttaggc ttctccacgg 480
cggtaaagac cagaaggcgg cggagagcca cgcaagagaa gaaggacgtg cgctcagctt 540
cgctcgcacc ggttgttgaa cttgggcgag cgcgagccgc ggctgccggg cgccccctcc 600
ccctagcagc ggaggagggg acaagtcgtc ggagtccggg cggccaagac ccgccgccgg 660
ccggccactg cagggtccgc actgatccgc tccgcgggga gagccgctgc tctgggaagt 720
gagttcgcct gcggactccg aggaaccgct gcgcccgaag agcgctcagt gagtgaccgc 780
gacttttcaa agccgggtag cgcgcgcgag tcgacaagta agagtgcggg aggcatctta 840
attaaccctg cgctccctgg agcgagctgg tgaggagggc gcagcgggga cgacagccag 900
cgggtgcgtg cgctcttaga gaaactttcc ctgtcaaagg ctccgggggg cgcgggtgtc 960
ccccgcttgc cagagccctg ttgcggcccc gaaacttgtg cgcgcagccc aaactaacct 1020
cacgtgaagt gacggactgt tctatgactg caaagatgga aacgaccttc tatgacgatg 1080
ccctcaacgc ctcgttcctc ccgtccgaga gcggacctta tggctacagt aaccccaaga 1140
tcctgaaaca gagcatgacc ctgaacctgg ccgacccagt ggggagcctg aagccgcacc 1200
tccgcgccaa gaactcggac ctcctcacct cgcccgacgt ggggctgctc aagctggcgt 1260
cgcccgagct ggagcgcctg ataatccagt ccagcaacgg gcacatcacc accacgccga 1320
cccccaccca gttcctgtgc cccaagaacg tgacagatga gcaggagggc ttcgccgagg 1380
gcttcgtgcg cgccctggcc gaactgcaca gccagaacac gctgcccagc gtcacgtcgg 1440
cggcgcagcc ggtcaacggg gcaggcatgg tggctcccgc ggtagcctcg gtggcagggg 1500
gcagcggcag cggcggcttc agcgccagcc tgcacagcga gccgccggtc tacgcaaacc 1560
tcagcaactt caacccaggc gcgctgagca gcggcggcgg ggcgccctcc tacggcgcgg 1620
ccggcctggc ctttcccgcg caaccccagc agcagcagca gccgccgcac cacctgcccc 1680
agcagatgcc cgtgcagcac ccgcggctgc aggccctgaa ggaggagcct cagacagtgc 1740
ccgagatgcc cggcgagaca ccgcccctgt cccccatcga catggagtcc caggagcgga 1800
tcaaggcgga gaggaagcgc atgaggaacc gcatcgctgc ctccaagtgc cgaaaaagga 1860
agctggagag aatcgcccgg ctggaggaaa aagtgaaaac cttgaaagct cagaactcgg 1920
agctggcgtc cacggccaac atgctcaggg aacaggtggc acagcttaaa cagaaagtca 1980
tgaaccacgt taacagtggg tgccaactca tgctaacgca gcagttgcaa acattttgaa 2040
gagagaccgt cgggggctga ggggcaacga agaaaaaaaa taacacagag agacagactt 2100
gagaacttga caagttgcga cggagagaaa aaagaagtgt ccgagaacta aagccaaggg 2160
tatccaagtt ggactgggtt gcgtcctgac ggcgccccca gtgtgcacga gtgggaagga 2220
cttggcgcgc cctcccttgg cgtggagcca gggagcggcc gcctgcgggc tgccccgctt 2280
tgcggacggg ctgtccccgc gcgaacggaa cgttggactt ttcgttaaca ttgaccaaga 2340
actgcatgga cctaacattc gatctcattc agtattaaag gggggagggg gagggggtta 2400
caaactgcaa tagagactgt agattgcttc tgtagtactc cttaagaaca caaagcgggg 2460
ggagggttgg ggaggggcgg caggagggag gtttgtgaga gcgaggctga gcctacagat 2520
gaactctttc tggcctgcct tcgttaactg tgtatgtaca tatatatatt ttttaatttg 2580
atgaaagctg attactgtca ataaacagct tcatgccttt gtaagttatt tcttgtttgt 2640
ttgtttgggt atcctgccca gtgttgtttg taaataagag atttggagca ctctgagttt 2700
accatttgta ataaagtata taattttttt atgttttgtt tctgaaaatt ccagaaagga 2760
tatttaagaa aatacaataa actattggaa agtactcccc taacctcttt tctgcatcat 2820
ctgtagatac tagctatcta ggtggagttg aaagagttaa gaatgtcgat taaaatcact 2880
ctcagtgctt cttactatta agcagtaaaa actgttctct attagacttt agaaataaat 2940
gtacctgatg tacctgatgc tatggtcagg ttatactcct cctcccccag ctatctatat 3000
ggaattgctt accaaaggat agtgcgatgt ttcaggaggc tggaggaagg ggggttgcag 3060
tggagaggga cagcccactg agaagtcaaa catttcaaag tttggattgt atcaagtggc 3120
atgtgctgtg accatttata atgttagtag aaattttaca ataggtgctt attctcaaag 3180
caggaattgg tggcagattt tacaaaagat gtatccttcc aatttggaat cttctctttg 3240
acaattccta gataaaaaga tggcctttgc ttatgaatat ttataacagc attcttgtca 3300
caataaatgt attcaaatac caaaaaaaaa aaaaaaaa                         3338

<210> 16
<211> 331
<212> PRT
<213> Homo sapiens

<400> 16
Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala
 1               5                  10                  15      
Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys
            20                  25                  30          
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser
        35                  40                  45              
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro
    50                  55                  60                  
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile
65                  70                  75                  80  
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln
                85                  90                  95      
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu
            100                 105                 110         
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro
        115                 120                 125             
Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala
    130                 135                 140                 
Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser
145                 150                 155                 160 
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe
                165                 170                 175     
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala
            180                 185                 190         
Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro
        195                 200                 205             
His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala
    210                 215                 220                 
Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro
225                 230                 235                 240 
Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu
                245                 250                 255     
Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg
            260                 265                 270         
Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys
        275                 280                 285             
Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln
    290                 295                 300                 
Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys
305                 310                 315                 320 
Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe
                325                 330     

<210> 17
<211> 4830
<212> DNA
<213> Homo sapiens

<400> 17
caaccggttc cgagtttgag gcactaggag gagggggaga agcggctgca gcggccgcgg 60
caggagcagc gggagctaca gcatcagcaa gagcaacagt agctacagcc ccggcggcgg 120
tgcctgttcc agtctttgct gctgcagtcc gtgcaaccac ccagaggggg aggggggaac 180
caccagtcgc tgaggaacaa gagaaggggg gaaagtttag gcgagccttg gggggggggg 240
ggccagcgcc ggagccgcgt gagagaggga gccgtgtttt ggtagggggg agtcggactg 300
caactggcag cagagcgtct ccccggccgt gtggactcta caccccctac tcctgccgct 360
tctgctgctg cctgtggctg gagggtcccc ctggggctga atctttggga cttgaccccg 420
ttccctcccc cttccctcac tccccagccg ggcgggagca tttattcccc agattaattc 480
cccttttggg ggggggcggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgggggaag 540
cgtccctgaa atagtaaata ttattgagct ctttttgccc ttttcctgtc cgttttttta 600
atttcctttt ttgaggtggg aaaactgaaa cccaccttga ttcgtcccct ctcccccctc 660
cccaccttcc ctcgccctaa tcccccaacg aggaaggaag gagcagttgg ttcaatctct 720
ggtaatctat gccagcaatt atgacaatgt tagcagacca tgcagctcgt cagctgcttg 780
atttcagcca aaaactggat atcaacttat tagataatgt ggtgaattgc ttataccatg 840
gagaaggagc ccagcaaaga atggctcaag aagtactgac acatttaaag gagcatcctg 900
atgcttggac aagagtcgac acaattttgg aattttctca gaatatgaat acgaaatact 960
atggactaca aattttggaa aatgtgataa aaacaaggtg gaagattctt ccaaggaacc 1020
agtgcgaagg aataaaaaaa tacgttgttg gcctcattat caagacgtca tctgacccaa 1080
cttgtgtaga gaaagaaaag gtgtatatcg gaaaattaaa tatgatcctt gttcagatac 1140
tgaaacaaga atggcccaaa cattggccaa cttttatcag tgatattgtt ggagcaagta 1200
ggaccagcga aagtctctgt caaaataata tggtgattct taaactcttg agtgaagaag 1260
tatttgattt ctctagtgga cagataaccc aagtcaaatc taagcattta aaagacagca 1320
tgtgcaatga attctcacag atatttcaac tgtgtcagtt tgtaatggaa aattctcaaa 1380
atgctccact tgtacatgca accttggaaa cattgctcag atttctgaac tggattcccc 1440
tgggatatat ttttgagacc aaattaatca gcacattgat ttataagttc ctgaatgttc 1500
caatgtttcg aaatgtctct ctgaagtgcc tcactgagat tgctggtgtg agtgtaagcc 1560
aatatgaaga acaatttgta acactattta ctctgacaat gatgcaacta aagcagatgc 1620
ttcctttaaa taccaatatt cgacttgcgt actcaaatgg aaaagatgat gaacagaact 1680
tcattcaaaa tctcagtttg tttctctgca cctttcttaa ggaacatgat caacttatag 1740
aaaaaagatt aaatctcagg gaaactctta tggaggccct tcattatatg ttgttggtat 1800
ctgaagtaga agaaactgaa atctttaaaa tttgtcttga atactggaat catttggctg 1860
ctgaactcta tagagagagt ccattctcta catctgcctc tccgttgctt tctggaagtc 1920
aacattttga tgttcctccc aggagacagc tatatttgcc catgttattc aaggtccgtt 1980
tattaatggt tagtcgaatg gctaaaccag aggaagtatt ggttgtagag aatgatcaag 2040
gagaagttgt gagagaattc atgaaggata cagattccat aaatttgtat aagaatatga 2100
gggaaacatt ggtttatctt actcatctgg attatgtaga tacagaaaga ataatgacag 2160
agaagcttca caatcaagtg aatggtacag agtggtcatg gaaaaatttg aatacattgt 2220
gttgggcaat aggctccatt agtggagcaa tgcatgaaga ggacgaaaaa cgatttcttg 2280
ttactgttat aaaggatcta ttaggattat gtgaacagaa aagaggcaaa gataataaag 2340
ctattattgc atcaaatatc atgtacatag taggtcaata cccacgtttt ttgagagctc 2400
actggaaatt tctgaagact gtagttaaca agctgttcga attcatgcat gagacccatg 2460
atggagtcca ggatatggct tgtgatactt tcattaaaat agcccaaaaa tgccgcaggc 2520
atttcgttca ggttcaggtt ggagaagtga tgccatttat tgatgaaatt ttgaacaaca 2580
ttaacactat tatttgtgat cttcagcctc aacaggttca tacgttttat gaagctgtgg 2640
ggtacatgat tggtgcacaa acagatcaaa cagtacaaga acacttgata gaaaagtaca 2700
tgttactccc taatcaagtg tgggatagta taatccagca ggcaaccaaa aatgtggata 2760
tactgaaaga tcctgaaaca gtcaagcagc ttggtagcat tttgaaaaca aatgtgagag 2820
cctgcaaagc tgttggacac ccctttgtaa ttcagcttgg aagaatttat ttagatatgc 2880
ttaatgtata caagtgcctc agtgaaaata tttctgcagc tatccaagct aatggtgaaa 2940
tggttacaaa gcaaccattg attagaagta tgcgaactgt aaaaagggaa actttaaagt 3000
taatatctgg ttgggtgagc cgatccaatg atccacagat ggtcgctgaa aattttgttc 3060
cccctctgtt ggatgcagtt ctcattgatt atcagagaaa tgtcccagct gctagagaac 3120
cagaagtgct tagtactatg gccataattg tcaacaagtt agggggacat ataacagctg 3180
aaatacctca aatatttgat gctgtttttg aatgcacatt gaatatgata aataaggact 3240
ttgaagaata tcctgaacat agaacgaact ttttcttact acttcaggct gtcaattctc 3300
attgtttccc agcattcctt gctattccac ctacacagtt taaacttgtt ttggattcca 3360
tcatttgggc tttcaaacat actatgagga atgtcgcaga tacgggctta cagatacttt 3420
ttacactctt acaaaatgtt gcacaagaag aagctgcagc tcagagtttt tatcaaactt 3480
atttttgtga tattctccag catatctttt ctgttgtgac agacacttca catactgctg 3540
gtttaacaat gcatgcatca attcttgcat atatgtttaa tttggttgaa gaaggaaaaa 3600
taagtacatc attaaatcct ggaaatccag ttaacaacca aatctttctt caggaatatg 3660
tggctaatct ccttaagtcg gccttccctc acctacaaga tgctcaagta aagctctttg 3720
tgacagggct tttcagctta aatcaagata ttcctgcttt caaggaacat ttaagagatt 3780
tcctagttca aataaaggaa tttgcaggtg aagacacttc tgatttgttt ttggaagaga 3840
gagaaatagc cctacggcag gctgatgaag agaaacataa acgtcaaatg tctgtccctg 3900
gcatctttaa tccacatgag attccagaag aaatgtgtga ttaaaatcca aattcatgct 3960
gttttttttc tctgcaactc gttagcagag gaaaacagca tgtgggtatt tgtcgaccaa 4020
aatgatgcca atttgtaaat taaaatgtca cctagtggcc ctttttctta tgtgtttttt 4080
tgtataagaa attttctgtg aaatatcctt ccattgttta agcttttgtt ttggtcatct 4140
ttatttagtt tgcatgaagt tgaaaattaa ggcattttta aaaattttac ttcatgccca 4200
tttttgtggc tgggctgggg ggaggaggca aattcgattt gaacatatac ttgtaattct 4260
aatgcaaaat tatacaattt ttcctgtaaa caataccaat ttttaattag ggagcatttt 4320
ccttctagtc tatttcagcc tagaagaaaa gataatgagt aaaacaaatt gcgttgttta 4380
aaggattata gtgctgcatt gtctgaagtt agcacctctt ggactgaatc gtttgtctag 4440
actacatgta ttacaaagtc tctttggcaa gattgcagca agatcatgtg catatcatcc 4500
cattgtaaag cgacttcaaa aatatgggaa cacagttagt tatttttaca cagttctttt 4560
tgtttttgtg tgtgtgtgct gtcgcttgtc gacaacagct ttttgttttc ctcaatgagg 4620
agtgttgctc atttgtgagc cttcattaac tcgaagtgaa atggttaaaa atatttatcc 4680
tgttagaata ggctgcatct ttttaacaac tcattaaaaa acaaaacaac tctggctttt 4740
gagatgactt atactaattt acattgttta ccaagctgta gtgctttaag aacactactt 4800
aaaaagcaaa ataaacttgg tttacattta                                  4830

<210> 18
<211> 1071
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Ala Ile Met Thr Met Leu Ala Asp His Ala Ala Arg Gln Leu
 1               5                  10                  15      
Leu Asp Phe Ser Gln Lys Leu Asp Ile Asn Leu Leu Asp Asn Val Val
            20                  25                  30          
Asn Cys Leu Tyr His Gly Glu Gly Ala Gln Gln Arg Met Ala Gln Glu
        35                  40                  45              
Val Leu Thr His Leu Lys Glu His Pro Asp Ala Trp Thr Arg Val Asp
    50                  55                  60                  
Thr Ile Leu Glu Phe Ser Gln Asn Met Asn Thr Lys Tyr Tyr Gly Leu
65                  70                  75                  80  
Gln Ile Leu Glu Asn Val Ile Lys Thr Arg Trp Lys Ile Leu Pro Arg
                85                  90                  95      
Asn Gln Cys Glu Gly Ile Lys Lys Tyr Val Val Gly Leu Ile Ile Lys
            100                 105                 110         
Thr Ser Ser Asp Pro Thr Cys Val Glu Lys Glu Lys Val Tyr Ile Gly
        115                 120                 125             
Lys Leu Asn Met Ile Leu Val Gln Ile Leu Lys Gln Glu Trp Pro Lys
    130                 135                 140                 
His Trp Pro Thr Phe Ile Ser Asp Ile Val Gly Ala Ser Arg Thr Ser
145                 150                 155                 160 
Glu Ser Leu Cys Gln Asn Asn Met Val Ile Leu Lys Leu Leu Ser Glu
                165                 170                 175     
Glu Val Phe Asp Phe Ser Ser Gly Gln Ile Thr Gln Val Lys Ser Lys
            180                 185                 190         
His Leu Lys Asp Ser Met Cys Asn Glu Phe Ser Gln Ile Phe Gln Leu
        195                 200                 205             
Cys Gln Phe Val Met Glu Asn Ser Gln Asn Ala Pro Leu Val His Ala
    210                 215                 220                 
Thr Leu Glu Thr Leu Leu Arg Phe Leu Asn Trp Ile Pro Leu Gly Tyr
225                 230                 235                 240 
Ile Phe Glu Thr Lys Leu Ile Ser Thr Leu Ile Tyr Lys Phe Leu Asn
                245                 250                 255     
Val Pro Met Phe Arg Asn Val Ser Leu Lys Cys Leu Thr Glu Ile Ala
            260                 265                 270         
Gly Val Ser Val Ser Gln Tyr Glu Glu Gln Phe Val Thr Leu Phe Thr
        275                 280                 285             
Leu Thr Met Met Gln Leu Lys Gln Met Leu Pro Leu Asn Thr Asn Ile
    290                 295                 300                 
Arg Leu Ala Tyr Ser Asn Gly Lys Asp Asp Glu Gln Asn Phe Ile Gln
305                 310                 315                 320 
Asn Leu Ser Leu Phe Leu Cys Thr Phe Leu Lys Glu His Asp Gln Leu
                325                 330                 335     
Ile Glu Lys Arg Leu Asn Leu Arg Glu Thr Leu Met Glu Ala Leu His
            340                 345                 350         
Tyr Met Leu Leu Val Ser Glu Val Glu Glu Thr Glu Ile Phe Lys Ile
        355                 360                 365             
Cys Leu Glu Tyr Trp Asn His Leu Ala Ala Glu Leu Tyr Arg Glu Ser
    370                 375                 380                 
Pro Phe Ser Thr Ser Ala Ser Pro Leu Leu Ser Gly Ser Gln His Phe
385                 390                 395                 400 
Asp Val Pro Pro Arg Arg Gln Leu Tyr Leu Pro Met Leu Phe Lys Val
                405                 410                 415     
Arg Leu Leu Met Val Ser Arg Met Ala Lys Pro Glu Glu Val Leu Val
            420                 425                 430         
Val Glu Asn Asp Gln Gly Glu Val Val Arg Glu Phe Met Lys Asp Thr
        435                 440                 445             
Asp Ser Ile Asn Leu Tyr Lys Asn Met Arg Glu Thr Leu Val Tyr Leu
    450                 455                 460                 
Thr His Leu Asp Tyr Val Asp Thr Glu Arg Ile Met Thr Glu Lys Leu
465                 470                 475                 480 
His Asn Gln Val Asn Gly Thr Glu Trp Ser Trp Lys Asn Leu Asn Thr
                485                 490                 495     
Leu Cys Trp Ala Ile Gly Ser Ile Ser Gly Ala Met His Glu Glu Asp
            500                 505                 510         
Glu Lys Arg Phe Leu Val Thr Val Ile Lys Asp Leu Leu Gly Leu Cys
        515                 520                 525             
Glu Gln Lys Arg Gly Lys Asp Asn Lys Ala Ile Ile Ala Ser Asn Ile
    530                 535                 540                 
Met Tyr Ile Val Gly Gln Tyr Pro Arg Phe Leu Arg Ala His Trp Lys
545                 550                 555                 560 
Phe Leu Lys Thr Val Val Asn Lys Leu Phe Glu Phe Met His Glu Thr
                565                 570                 575     
His Asp Gly Val Gln Asp Met Ala Cys Asp Thr Phe Ile Lys Ile Ala
            580                 585                 590         
Gln Lys Cys Arg Arg His Phe Val Gln Val Gln Val Gly Glu Val Met
        595                 600                 605             
Pro Phe Ile Asp Glu Ile Leu Asn Asn Ile Asn Thr Ile Ile Cys Asp
    610                 615                 620                 
Leu Gln Pro Gln Gln Val His Thr Phe Tyr Glu Ala Val Gly Tyr Met
625                 630                 635                 640 
Ile Gly Ala Gln Thr Asp Gln Thr Val Gln Glu His Leu Ile Glu Lys
                645                 650                 655     
Tyr Met Leu Leu Pro Asn Gln Val Trp Asp Ser Ile Ile Gln Gln Ala
            660                 665                 670         
Thr Lys Asn Val Asp Ile Leu Lys Asp Pro Glu Thr Val Lys Gln Leu
        675                 680                 685             
Gly Ser Ile Leu Lys Thr Asn Val Arg Ala Cys Lys Ala Val Gly His
    690                 695                 700                 
Pro Phe Val Ile Gln Leu Gly Arg Ile Tyr Leu Asp Met Leu Asn Val
705                 710                 715                 720 
Tyr Lys Cys Leu Ser Glu Asn Ile Ser Ala Ala Ile Gln Ala Asn Gly
                725                 730                 735     
Glu Met Val Thr Lys Gln Pro Leu Ile Arg Ser Met Arg Thr Val Lys
            740                 745                 750         
Arg Glu Thr Leu Lys Leu Ile Ser Gly Trp Val Ser Arg Ser Asn Asp
        755                 760                 765             
Pro Gln Met Val Ala Glu Asn Phe Val Pro Pro Leu Leu Asp Ala Val
    770                 775                 780                 
Leu Ile Asp Tyr Gln Arg Asn Val Pro Ala Ala Arg Glu Pro Glu Val
785                 790                 795                 800 
Leu Ser Thr Met Ala Ile Ile Val Asn Lys Leu Gly Gly His Ile Thr
                805                 810                 815     
Ala Glu Ile Pro Gln Ile Phe Asp Ala Val Phe Glu Cys Thr Leu Asn
            820                 825                 830         
Met Ile Asn Lys Asp Phe Glu Glu Tyr Pro Glu His Arg Thr Asn Phe
        835                 840                 845             
Phe Leu Leu Leu Gln Ala Val Asn Ser His Cys Phe Pro Ala Phe Leu
    850                 855                 860                 
Ala Ile Pro Pro Thr Gln Phe Lys Leu Val Leu Asp Ser Ile Ile Trp
865                 870                 875                 880 
Ala Phe Lys His Thr Met Arg Asn Val Ala Asp Thr Gly Leu Gln Ile
                885                 890                 895     
Leu Phe Thr Leu Leu Gln Asn Val Ala Gln Glu Glu Ala Ala Ala Gln
            900                 905                 910         
Ser Phe Tyr Gln Thr Tyr Phe Cys Asp Ile Leu Gln His Ile Phe Ser
        915                 920                 925             
Val Val Thr Asp Thr Ser His Thr Ala Gly Leu Thr Met His Ala Ser
    930                 935                 940                 
Ile Leu Ala Tyr Met Phe Asn Leu Val Glu Glu Gly Lys Ile Ser Thr
945                 950                 955                 960 
Ser Leu Asn Pro Gly Asn Pro Val Asn Asn Gln Ile Phe Leu Gln Glu
                965                 970                 975     
Tyr Val Ala Asn Leu Leu Lys Ser Ala Phe Pro His Leu Gln Asp Ala
            980                 985                 990         
Gln Val Lys Leu Phe Val Thr Gly Leu Phe Ser Leu Asn Gln Asp Ile
        995                 1000                1005            
Pro Ala Phe Lys Glu His Leu Arg Asp Phe Leu Val Gln Ile Lys Glu
    1010                1015                1020                
Phe Ala Gly Glu Asp Thr Ser Asp Leu Phe Leu Glu Glu Arg Glu Ile
1025                1030                1035               1040 
Ala Leu Arg Gln Ala Asp Glu Glu Lys His Lys Arg Gln Met Ser Val
                1045                1050                1055    
Pro Gly Ile Phe Asn Pro His Glu Ile Pro Glu Glu Met Cys Asp
            1060                1065                1070    

<210> 19
<211> 4099
<212> DNA
<213> Homo sapiens

<400> 19
agccagccct tgccgtggcc ggagccgagc ggcgcatccg ggccggagaa gaggacgacg 60
acgaggtcct cgaagtggac ccgtttgcga agcgccaggg agaaggagga gcggacgcat 120
cgtagaaagg ggtggtggcg cccgaccccg cgccccggcc cgaagctctg agggcttccc 180
ggcccccact gcctgcggca tggcccgggg ctcggcgctc ccgcggcggc cgctgctgtg 240
catcccggcc gtctgggcgg ccgccgcgct tctgctctca gtgtcccgga cttcaggtga 300
agtggaggtt ctggatccga acgacccttt aggacccctt gatgggcagg acggcccgat 360
tccaactctg aaaggttact ttctgaattt tctggagcca gtaaacaata tcaccattgt 420
ccaaggccag acggcaattc tgcactgcaa ggtggcagga aacccacccc ctaacgtgcg 480
gtggctaaag aatgatgccc cggtggtgca ggagccgcgg cggatcatca tccggaagac 540
agaatatggt tcacgactgc gaatccagga cctggacacg acagacactg gctactacca 600
gtgcgtggcc accaacggga tgaagaccat taccgccact ggcgtcctgt ttgtgcggct 660
gggtccaacg cacagcccaa atcataactt tcaggatgat taccacgagg atgggttctg 720
ccagccttac cggggaattg cctgtgcacg cttcattggc aaccggacca tttatgtgga 780
ctcgcttcag atgcaggggg agattgaaaa ccgaatcaca gcggccttca ccatgatcgg 840
cacgtctacg cacctgtcgg accagtgctc acagttcgcc atcccatcct tctgccactt 900
cgtgtttcct ctgtgcgacg cgcgctcccg gacacccaag ccgcgtgagc tgtgccgcga 960
cgagtgcgag gtgctggaga gcgacctgtg ccgccaggag tacaccatcg cccgctccaa 1020
cccgctcatc ctcatgcggc ttcagctgcc caagtgtgag gcgctgccca tgcctgagag 1080
ccccgacgct gccaactgca tgcgcattgg catcccagcc gagaggctgg gccgctacca 1140
tcagtgctat aacggctcag gcatggatta cagaggaacg gcaagcacca ccaagtcagg 1200
ccaccagtgc cagccgtggg ccctgcagca cccccacagc caccacctgt ccagcacaga 1260
cttccctgag cttggagggg ggcacgccta ctgccggaac cccggaggcc agatggaggg 1320
cccctggtgc tttacgcaga ataaaaacgt acgcatggaa ctgtgtgacg taccctcgtg 1380
tagtccccga gacagcagca agatggggat tctgtacatc ttggtcccca gcatcgcaat 1440
tccactggtc atcgcttgcc ttttcttctt ggtttgcatg tgccggaata agcagaaggc 1500
atctgcgtcc acaccgcagc ggcgacagct gatggcctcg cccagccaag acatggaaat 1560
gcccctcatt aaccagcaca aacaggccaa actcaaagag atcagcctgt ctgcggtgag 1620
gttcatggag gagctgggag aggaccggtt tgggaaagtc tacaaaggtc acctgttcgg 1680
ccctgccccg ggggagcaga cccaggctgt ggccatcaaa acgctgaagg acaaagcgga 1740
ggggcccctg cgggaggagt tccggcatga ggctatgctg cgagcacggc tgcaacaccc 1800
caacgtcgtc tgcctgctgg gcgtggtgac caaggaccag cccctgagca tgatcttcag 1860
ctactgttcg cacggcgacc tccacgaatt cctggtcatg cgctcgccgc actcggacgt 1920
gggcagcacc gatgatgacc gcacggtgaa gtccgccctg gagccccccg acttcgtgca 1980
ccttgtggca cagatcgcgg cggggatgga gtacctatcc agccaccacg tggttcacaa 2040
ggacctggcc acccgcaatg tgctagtgta cgacaagctg aacgtgaaga tctcagactt 2100
gggcctcttc cgagaggtgt atgccgccga ttactacaag ctgctgggga actcgctgct 2160
gcctatccgc tggatggccc cagaggccat catgtacggc aagttctcca tcgactcaga 2220
catctggtcc tacggtgtgg tcctgtggga ggtcttcagc tacggcctgc agccctactg 2280
cgggtactcc aaccaggatg tggtggagat gatccggaac cggcaggtgc tgccttgccc 2340
cgatgactgt cccgcctggg tgtatgccct catgatcgag tgctggaacg agttccccag 2400
ccggcggccc cgcttcaagg acatccacag ccggctccga gcctggggca acctttccaa 2460
ctacaacagc tcggcgcaga cctcgggggc cagcaacacc acgcagacca gctccctgag 2520
caccagccca gtgagcaatg tgagcaacgc ccgctacgtg gggcccaagc agaaggcccc 2580
gcccttccca cagccccagt tcatccccat gaagggccag atcagaccca tggtgccccc 2640
gccgcagctc tacgtccccg tcaacggcta ccagccggtg ccggcctatg gggcctacct 2700
gcccaacttc tacccggtgc agatcccaat gcagatggcc ccgcagcagg tgcctcctca 2760
gatggtcccc aagcccagct cacaccacag tggcagtggc tccaccagca caggctacgt 2820
caccacggcc ccctccaaca catccatggc agacagggca gccctgctct cagagggcgc 2880
tgatgacaca cagaacgccc cagaagatgg ggcccagagc accgtgcagg aagcagagga 2940
ggaggaggaa ggctctgtcc cagagactga gctgctgggg gactgtgaca ctctgcaggt 3000
ggacgaggcc caagtccagc tggaagcttg agtggcacca gggcccgggg ttcggggata 3060
gaagccccgc cgagacccca cagggacctc agtcaccttt gagaagacac catactcagc 3120
aatcacaaga gcccgccggc cagtgggctt gtttgcagac tgggtgaggt ggagccctgc 3180
tcctctctgt cctctgacac agagagctgc cctgcctagg agcacccaag ccaggcaggg 3240
ggtctggcag cacggcgtcc tggggagcag gacacatggt catccccagg gctgtataca 3300
ttgattctgg tggtagactg gtagtgagca gcaaatgcct ttcaagaaaa taggtggcag 3360
cttcactcca tgtcatatat ggagtgaata tttcaaaacg ttgggaataa gggcctgcaa 3420
aaggcagcga ggaggcacct cgggtcttga ggttcctgac aaccgatctg gtctgttggt 3480
ttgaggatga aggggctcca tttctgctgc ctccctgctg agaatattct ccctttagca 3540
gccaaagatt cgctggaacg gaggctgccc tctgctgcct gttggggtcg gaagacaagg 3600
ggcttctgaa atgggagttc ctgagataca acaaaatgtg tgccttcaaa gaaactgaca 3660
gctttgtatt tggtgaaatg gttttaatta tactccatgt gtattttgcc cacttttttt 3720
gggaattcaa gggaaagtgt ttcttgggtt tggaatgttc agaggaagca gtattgtaca 3780
gaacacggta ttgttatttt tgttaagaat catgtacaga gcttaaatgt aatttatatg 3840
tttttaatat gccattttca ttgaagtatt ttggtcttaa gatgacttta gtaatttaac 3900
tgtttatgtt acccacgttg ggatccagtt ggtcttggtt tgcttctctc tgtaccacgt 3960
gcacatgagg tccattcatt ttacagcccc tgttacacac agacccacag gcagccgtct 4020
gtgccccgca cacattgttg gtcctatttg taaatcccac acccggtgta tccaataaag 4080
tgaaacaaag catgtgaaa                                              4099

<210> 20
<211> 943
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro
 1               5                  10                  15      
Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser
            20                  25                  30          
Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp
        35                  40                  45              
Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe
    50                  55                  60                  
Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile
65                  70                  75                  80  
Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu
                85                  90                  95      
Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg
            100                 105                 110         
Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr
        115                 120                 125             
Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile
    130                 135                 140                 
Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro
145                 150                 155                 160 
Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro
                165                 170                 175     
Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr
            180                 185                 190         
Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala
        195                 200                 205             
Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser
    210                 215                 220                 
Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp
225                 230                 235                 240 
Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys
                245                 250                 255     
Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg
            260                 265                 270         
Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala
        275                 280                 285             
Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly
    290                 295                 300                 
Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser
305                 310                 315                 320 
Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln
                325                 330                 335     
Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser
            340                 345                 350         
Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro
        355                 360                 365             
Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val
    370                 375                 380                 
Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser
385                 390                 395                 400 
Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu
                405                 410                 415     
Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln
            420                 425                 430         
Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro
        435                 440                 445             
Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys
    450                 455                 460                 
Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly
465                 470                 475                 480 
Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala
                485                 490                 495     
Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys
            500                 505                 510         
Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg
        515                 520                 525             
Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr
    530                 535                 540                 
Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp
545                 550                 555                 560 
Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser
                565                 570                 575     
Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe
            580                 585                 590         
Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser
        595                 600                 605             
His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr
    610                 615                 620                 
Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val
625                 630                 635                 640 
Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile
                645                 650                 655     
Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp
            660                 665                 670         
Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr
        675                 680                 685             
Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met
    690                 695                 700                 
Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp
705                 710                 715                 720 
Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg
                725                 730                 735     
Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu
            740                 745                 750         
Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr
        755                 760                 765             
Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala
    770                 775                 780                 
Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln
785                 790                 795                 800 
Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln
                805                 810                 815     
Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala
            820                 825                 830         
Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro
        835                 840                 845             
Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser
    850                 855                 860                 
Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn
865                 870                 875                 880 
Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp
                885                 890                 895     
Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala
            900                 905                 910         
Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp
        915                 920                 925             
Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala
    930                 935                 940             

<210> 21
<211> 4304
<212> DNA
<213> Homo sapiens

<400> 21
cacacggact acaggggagt tttgttgaag ttgcaaagtc ctggagcctc cagagggctg 60
tcggcgcagt agcagcgagc agcagagtcc gcacgctccg gcgaggggca gaagagcgcg 120
agggagcgcg gggcagcaga agcgagagcc gagcgcggac ccagccagga cccacagccc 180
tccccagctg cccaggaaga gccccagcca tggaacacca gctcctgtgc tgcgaagtgg 240
aaaccatccg ccgcgcgtac cccgatgcca acctcctcaa cgaccgggtg ctgcgggcca 300
tgctgaaggc ggaggagacc tgcgcgccct cggtgtccta cttcaaatgt gtgcagaagg 360
aggtcctgcc gtccatgcgg aagatcgtcg ccacctggat gctggaggtc tgcgaggaac 420
agaagtgcga ggaggaggtc ttcccgctgg ccatgaacta cctggaccgc ttcctgtcgc 480
tggagcccgt gaaaaagagc cgcctgcagc tgctgggggc cacttgcatg ttcgtggcct 540
ctaagatgaa ggagaccatc cccctgacgg ccgagaagct gtgcatctac accgacaact 600
ccatccggcc cgaggagctg ctgcaaatgg agctgctcct ggtgaacaag ctcaagtgga 660
acctggccgc aatgaccccg cacgatttca ttgaacactt cctctccaaa atgccagagg 720
cggaggagaa caaacagatc atccgcaaac acgcgcagac cttcgttgcc ctctgtgcca 780
cagatgtgaa gttcatttcc aatccgccct ccatggtggc agcggggagc gtggtggccg 840
cagtgcaagg cctgaacctg aggagcccca acaacttcct gtcctactac cgcctcacac 900
gcttcctctc cagagtgatc aagtgtgacc cggactgcct ccgggcctgc caggagcaga 960
tcgaagccct gctggagtca agcctgcgcc aggcccagca gaacatggac cccaaggccg 1020
ccgaggagga ggaagaggag gaggaggagg tggacctggc ttgcacaccc accgacgtgc 1080
gggacgtgga catctgaggg cgccaggcag gcgggcgcca ccgccacccg cagcgagggc 1140
ggagccggcc ccaggtgctc ccctgacagt ccctcctctc cggagcattt tgataccaga 1200
agggaaagct tcattctcct tgttgttggt tgttttttcc tttgctcttt cccccttcca 1260
tctctgactt aagcaaaaga aaaagattac ccaaaaactg tctttaaaag agagagagag 1320
aaaaaaaaaa tagtatttgc ataaccctga gcggtggggg aggagggttg tgctacagat 1380
gatagaggat tttatacccc aataatcaac tcgtttttat attaatgtac ttgtttctct 1440
gttgtaagaa taggcattaa cacaaaggag gcgtctcggg agaggattag gttccatcct 1500
ttacgtgttt aaaaaaaagc ataaaaacat tttaaaaaca tagaaaaatt cagcaaacca 1560
tttttaaagt agaagagggt tttaggtaga aaaacatatt cttgtgcttt tcctgataaa 1620
gcacagctgt agtggggttc taggcatctc tgtactttgc ttgctcatat gcatgtagtc 1680
actttataag tcattgtatg ttattatatt ccgtaggtag atgtgtaacc tcttcacctt 1740
attcatggct gaagtcacct cttggttaca gtagcgtagc gtgcccgtgt gcatgtcctt 1800
tgcgcctgtg accaccaccc caacaaacca tccagtgaca aaccatccag tggaggtttg 1860
tcgggcacca gccagcgtag cagggtcggg aaaggccacc tgtcccactc ctacgatacg 1920
ctactataaa gagaagacga aatagtgaca taatatattc tatttttata ctcttcctat 1980
ttttgtagtg acctgtttat gagatgctgg ttttctaccc aacggccctg cagccagctc 2040
acgtccaggt tcaacccaca gctacttggt ttgtgttctt cttcatattc taaaaccatt 2100
ccatttccaa gcactttcag tccaataggt gtaggaaata gcgctgtttt tgttgtgtgt 2160
gcagggaggg cagttttcta atggaatggt ttgggaatat ccatgtactt gtttgcaagc 2220
aggactttga ggcaagtgtg ggccactgtg gtggcagtgg aggtggggtg tttgggaggc 2280
tgcgtgccag tcaagaagaa aaaggtttgc attctcacat tgccaggatg ataagttcct 2340
ttccttttct ttaaagaagt tgaagtttag gaatcctttg gtgccaactg gtgtttgaaa 2400
gtagggacct cagaggttta cctagagaac aggtggtttt taagggttat cttagatgtt 2460
tcacaccgga aggtttttaa acactaaaat atataattta tagttaaggc taaaaagtat 2520
atttattgca gaggatgttc ataaggccag tatgatttat aaatgcaatc tccccttgat 2580
ttaaacacac agatacacac acacacacac acacacacaa accttctgcc tttgatgtta 2640
cagatttaat acagtttatt tttaaagata gatcctttta taggtgagaa aaaaacaatc 2700
tggaagaaaa aaaccacaca aagacattga ttcagcctgt ttggcgtttc ccagagtcat 2760
ctgattggac aggcatgggt gcaaggaaaa ttagggtact caacctaagt tcggttccga 2820
tgaattctta tcccctgccc cttcctttaa aaaacttagt gacaaaatag acaatttgca 2880
catcttggct atgtaattct tgtaattttt atttaggaag tgttgaaggg aggtggcaag 2940
agtgtggagg ctgacgtgtg agggaggaca ggcgggagga ggtgtgagga ggaggctccc 3000
gaggggaagg ggcggtgccc acaccgggga caggccgcag ctccattttc ttattgcgct 3060
gctaccgttg acttccaggc acggtttgga aatattcaca tcgcttctgt gtatctcttt 3120
cacattgttt gctgctattg gaggatcagt tttttgtttt acaatgtcat atactgccat 3180
gtactagttt tagttttctc ttagaacatt gtattacaga tgcctttttt gtagtttttt 3240
ttttttttat gtgatcaatt ttgacttaat gtgattactg ctctattcca aaaaggttgc 3300
tgtttcacaa tacctcatgc ttcacttagc catggtggac ccagcgggca ggttctgcct 3360
gctttggcgg gcagacacgc gggcgcgatc ccacacaggc tggcgggggc cggccccgag 3420
gccgcgtgcg tgagaaccgc gccggtgtcc ccagagacca ggctgtgtcc ctcttctctt 3480
ccctgcgcct gtgatgctgg gcacttcatc tgatcggggg cgtagcatca tagtagtttt 3540
tacagctgtg ttattctttg cgtgtagcta tggaagttgc ataattatta ttattattat 3600
tataacaagt gtgtcttacg tgccaccacg gcgttgtacc tgtaggactc tcattcggga 3660
tgattggaat agcttctgga atttgttcaa gttttgggta tgtttaatct gttatgtact 3720
agtgttctgt ttgttattgt tttgttaatt acaccataat gctaatttaa agagactcca 3780
aatctcaatg aagccagctc acagtgctgt gtgccccggt cacctagcaa gctgccgaac 3840
caaaagaatt tgcaccccgc tgcgggccca cgtggttggg gccctgccct ggcagggtca 3900
tcctgtgctc ggaggccatc tcgggcacag gcccaccccg ccccacccct ccagaacacg 3960
gctcacgctt acctcaacca tcctggctgc ggcgtctgtc tgaaccacgc gggggccttg 4020
agggacgctt tgtctgtcgt gatggggcaa gggcacaagt cctggatgtt gtgtgtatcg 4080
agaggccaaa ggctggtggc aagtgcacgg ggcacagcgg agtctgtcct gtgacgcgca 4140
agtctgaggg tctgggcggc gggcggctgg gtctgtgcat ttctggttgc accgcggcgc 4200
ttcccagcac caacatgtaa ccggcatgtt tccagcagaa gacaaaaaga caaacatgaa 4260
agtctagaaa taaaactggt aaaaccccaa aaaaaaaaaa aaaa                  4304

<210> 22
<211> 295
<212> PRT
<213> Homo sapiens

<400> 22
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala
 1               5                  10                  15      
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu
            20                  25                  30          
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val
        35                  40                  45              
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met
    50                  55                  60                  
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu
65                  70                  75                  80  
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys
                85                  90                  95      
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys
            100                 105                 110         
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr
        115                 120                 125             
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu
    130                 135                 140                 
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe
145                 150                 155                 160 
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln
                165                 170                 175     
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp
            180                 185                 190         
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val
        195                 200                 205             
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu
    210                 215                 220                 
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp
225                 230                 235                 240 
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu
                245                 250                 255     
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu
            260                 265                 270         
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr
        275                 280                 285             
Asp Val Arg Asp Val Asp Ile
    290                 295 

<210> 23
<211> 3415
<212> DNA
<213> Homo sapiens

<400> 23
aggatacagc ggcttctgcg cgacttataa gagctccttg tgcggcgcca ttttaagcct 60
ctcggtctgt ggcagcagcg ttggcccggc cccgggagcg gagagcgagg ggaggcggag 120
acggaggaag gtctgaggag cagcttcagt ccccgccgag ccgccaccgc aggtcgagga 180
cggtcggact cccgcggcgg gaggagcctg ttcccctgag ggtatttgaa gtataccata 240
caactgtttt gaaaatccag cgtggacaat ggctactcaa gctgatttga tggagttgga 300
catggccatg gaaccagaca gaaaagcggc tgttagtcac tggcagcaac agtcttacct 360
ggactctgga atccattctg gtgccactac cacagctcct tctctgagtg gtaaaggcaa 420
tcctgaggaa gaggatgtgg atacctccca agtcctgtat gagtgggaac agggattttc 480
tcagtccttc actcaagaac aagtagctga tattgatgga cagtatgcaa tgactcgagc 540
tcagagggta cgagctgcta tgttccctga gacattagat gagggcatgc agatcccatc 600
tacacagttt gatgctgctc atcccactaa tgtccagcgt ttggctgaac catcacagat 660
gctgaaacat gcagttgtaa acttgattaa ctatcaagat gatgcagaac ttgccacacg 720
tgcaatccct gaactgacaa aactgctaaa tgacgaggac caggtggtgg ttaataaggc 780
tgcagttatg gtccatcagc tttctaaaaa ggaagcttcc agacacgcta tcatgcgttc 840
tcctcagatg gtgtctgcta ttgtacgtac catgcagaat acaaatgatg tagaaacagc 900
tcgttgtacc gctgggacct tgcataacct ttcccatcat cgtgagggct tactggccat 960
ctttaagtct ggaggcattc ctgccctggt gaaaatgctt ggttcaccag tggattctgt 1020
gttgttttat gccattacaa ctctccacaa ccttttatta catcaagaag gagctaaaat 1080
ggcagtgcgt ttagctggtg ggctgcagaa aatggttgcc ttgctcaaca aaacaaatgt 1140
taaattcttg gctattacga cagactgcct tcaaatttta gcttatggca accaagaaag 1200
caagctcatc atactggcta gtggtggacc ccaagcttta gtaaatataa tgaggaccta 1260
tacttacgaa aaactactgt ggaccacaag cagagtgctg aaggtgctat ctgtctgctc 1320
tagtaataag ccggctattg tagaagctgg tggaatgcaa gctttaggac ttcacctgac 1380
agatccaagt caacgtcttg ttcagaactg tctttggact ctcaggaatc tttcagatgc 1440
tgcaactaaa caggaaggga tggaaggtct ccttgggact cttgttcagc ttctgggttc 1500
agatgatata aatgtggtca cctgtgcagc tggaattctt tctaacctca cttgcaataa 1560
ttataagaac aagatgatgg tctgccaagt gggtggtata gaggctcttg tgcgtactgt 1620
ccttcgggct ggtgacaggg aagacatcac tgagcctgcc atctgtgctc ttcgtcatct 1680
gaccagccga caccaagaag cagagatggc ccagaatgca gttcgccttc actatggact 1740
accagttgtg gttaagctct tacacccacc atcccactgg cctctgataa aggctactgt 1800
tggattgatt cgaaatcttg ccctttgtcc cgcaaatcat gcacctttgc gtgagcaggg 1860
tgccattcca cgactagttc agttgcttgt tcgtgcacat caggataccc agcgccgtac 1920
gtccatgggt gggacacagc agcaatttgt ggagggggtc cgcatggaag aaatagttga 1980
aggttgtacc ggagcccttc acatcctagc tcgggatgtt cacaaccgaa ttgttatcag 2040
aggactaaat accattccat tgtttgtgca gctgctttat tctcccattg aaaacatcca 2100
aagagtagct gcaggggtcc tctgtgaact tgctcaggac aaggaagctg cagaagctat 2160
tgaagctgag ggagccacag ctcctctgac agagttactt cactctagga atgaaggtgt 2220
ggcgacatat gcagctgctg ttttgttccg aatgtctgag gacaagccac aagattacaa 2280
gaaacggctt tcagttgagc tgaccagctc tctcttcaga acagagccaa tggcttggaa 2340
tgagactgct gatcttggac ttgatattgg tgcccaggga gaaccccttg gatatcgcca 2400
ggatgatcct agctatcgtt cttttcactc tggtggatat ggccaggatg ccttgggtat 2460
ggaccccatg atggaacatg agatgggtgg ccaccaccct ggtgctgact atccagttga 2520
tgggctgcca gatctggggc atgcccagga cctcatggat gggctgcctc caggtgacag 2580
caatcagctg gcctggtttg atactgacct gtaaatcatc ctttagctgt attgtctgaa 2640
cttgcattgt gattggcctg tagagttgct gagagggctc gaggggtggg ctggtatctc 2700
agaaagtgcc tgacacacta accaagctga gtttcctatg ggaacaattg aagtaaactt 2760
tttgttctgg tcctttttgg tcgaggagta acaatacaaa tggattttgg gagtgactca 2820
agaagtgaag aatgcacaag aatggatcac aagatggaat ttatcaaacc ctagccttgc 2880
ttgttaaatt tttttttttt tttttttaag aatatctgta atggtactga ctttgcttgc 2940
tttgaagtag ctcttttttt tttttttttt ttttttttgc agtaactgtt ttttaagtct 3000
ctcgtagtgt taagttatag tgaatactgc tacagcaatt tctaattttt aagaattgag 3060
taatggtgta gaacactaat tcataatcac tctaattaat tgtaatctga ataaagtgta 3120
acaattgtgt agcctttttg tataaaatag acaaatagaa aatggtccaa ttagtttcct 3180
ttttaatatg cttaaaataa gcaggtggat ctatttcatg tttttgatca aaaactattt 3240
gggatatgta tgggtagggt aaatcagtaa gaggtgttat ttggaacctt gttttggaca 3300
gtttaccagt tgccttttat cccaaagttg ttgtaacctg ctgtgatacg atgcttcaag 3360
agaaaatgcg gttataaaaa atggttcaga attaaacttt taattcattc gattg      3415

<210> 24
<211> 781
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15      
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30          
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45              
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60                  
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80  
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95      
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110         
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125             
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140                 
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160 
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175     
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190         
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205             
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220                 
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240 
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255     
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270         
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285             
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300                 
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320 
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335     
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350         
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365             
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380                 
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400 
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415     
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430         
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445             
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460                 
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480 
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495     
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510         
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525             
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540                 
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560 
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575     
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590         
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605             
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620                 
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640 
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655     
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670         
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685             
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700                 
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720 
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735     
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750         
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765             
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780     

<210> 25
<211> 6945
<212> DNA
<213> Homo sapiens

<400> 25
atgagaaatt ctgaagaaca gccaagtgga gggaccacgg tattgcagcg tttgctacaa 60
gagcagcttc gctatggcaa tcctagtgag aatcgcagcc tgcttgccat acaccagcaa 120
gccacaggga atggccctcc tttccccagt ggcagtggga acccgggccc tcagagtgat 180
gtgttgagtc cccaagacca ccaccaacag cttgtggctc atgctgctcg acaagaaccc 240
caggggcagg aaatccagtc agaaaacctc atcatggaga agcagctgtc tcctcgaatg 300
caaaataatg aagaactccc gacctatgaa gaagccaagg tccagtccca gtactttcgg 360
ggccaacagc atgccagtgt tggagctgcc ttctatgtca ctggagtcac caaccagaag 420
atgaggactg agggacgccc atcagttcag cggctcaatc ctggaaagat gcaccaagat 480
gagggactca gagaccttaa gcaagggcat gtccgttcct tgagtgaacg actaatgcag 540
atgtcactgg ccaccagtgg agttaaggcc catccacctg ttaccagtgc tcccctctcc 600
ccaccacaac ccaatgacct ctacaagaat cccacaagtt ccagtgaatt ctacaaggcc 660
caagggccac ttcctaacca gcatagcctg aagggcatgg aacaccgagg ccccccacca 720
gaatatccct tcaagggcat gccaccccaa tctgtagtgt gcaagcccca agagccaggg 780
cacttctata gtgagcatcg cctgaaccag ccagggagaa cagaggggca actgatgagg 840
tatcagcatc cccctgagta tggagcagcc aggccagcgc aggacatctc attgccattg 900
tcagccagga actcgcagcc tcacagccct acttcttctc tgacctctgg ggggtccttg 960
cccttgctac aatctccacc atccactaga ttgtctcctg cccgacaccc cttggtccca 1020
aaccagggag accattcagc tcacctgcct aggccgcagc agcatttcct tcctaatcag 1080
gctcaccagg gggatcatta ccgtctctcc caacctggcc tgagtcagca gcagcagcaa 1140
cagcagcagc agcaccatca tcaccatcac caccaacaac agcagcagca gcagccacag 1200
cagcagccag gagaagccta ttcagctatg cctcgggctc agccatcctc tgcttcttat 1260
cagccagtgc cagcagaccc ttttgccatt gtttccagag cccagcagat ggttgagatc 1320
ctctcagacg agaaccggaa cttgaggcaa gagttggaag gatgctatga gaaggtggca 1380
agactgcaga aggtggagac agaaatccag cgcgtctcgg aggcatatga gaacctcgtg 1440
aagtcatcct ccaaaagaga ggccctagag aaagccatga gaaacaagct agagggcgag 1500
attcggagga tgcatgattt caacagggat ctgagagagc gtctagagac tgccaacaag 1560
cagcttgcag agaaggaata tgaggggtca gaggacacca gaaaaaccat ctcgcagctc 1620
tttgcaaaaa ataaagaaag ccagcgtgag aaggagaagc tggaagcgga gctggccact 1680
gcccgttcta ccaatgagga ccaaagacga cacatcgaaa tccgagatca ggccctgagt 1740
aatgcccagg ccaaggtggt aaagctggaa gaagagctga aaaagaagca agtgtacgtt 1800
gacaaggtgg agaagatgca gcaggccctt gtacagctcc aggcagcatg tgaaaaacgt 1860
gagcagctag agcaccgtct ccggacacga ctggagaggg aactggaatc cctgagaatc 1920
cagcagcgtc agggcaactg tcagcccacc aacgtttcag aatacaatgc tgctgcactg 1980
atggagctcc ttcgggagaa agaggagagg attctggctc tggaagctga tatgacaaag 2040
tgggagcaga aatatttgga ggagaatgtg atgagacatt ttgctctgga tgctgctgca 2100
actgtggctg ctcagaggga cacaacagtc atcagtcact ctcctaacac cagctatgac 2160
acagctctag aagctcgcat ccagaaagag gaggaagaaa tcttgatggc caataagcgt 2220
tgccttgaca tggagggcag gattaagacc ctccatgccc agattattga gaaggatgcc 2280
atgatcaaag tactccagca gcgttcccgg aaggagccga gcaagacaga gcagctgtcg 2340
tgcatgcggc cagcgaagtc tctgatgtcc atttccaatg ctggatcagg cttgctctcc 2400
cactcatcca ccctgactgg ctcccccatc atggaagaaa agcgagacga caagagctgg 2460
aaggggagcc taggcattct cctgggtgga gactaccgtg ctgaatatgt cccttccaca 2520
ccctcgcctg tgccaccctc gactcccctg ctctcggctc actccaagac aggcagccga 2580
gactgcagta cccaaactga acgtgggacg gaatcgaaca aaactgcagc tgttgctccc 2640
atctctgttc ctgctccagt tgctgctgcc gccactgctg ccgccatcac tgccactgct 2700
gccaccatca ccaccaccat ggtagctgct gctccagttg ctgttgctgc tgctgctgct 2760
ccagctgctg ctgctgcccc gtctccagcc actgccgctg ctactgctgc tgctgtttct 2820
ccagctgctg ctggtcagat tccagctgct gcctctgttg cctcagctgc tgccgttgct 2880
ccttctgctg ctgctgctgc tgctgttcag gttgctccag ctgctccggc tccagttcca 2940
gctccggctc tggttccggt tccagctcca gcagcggctc aggcttctgc tcctgctcag 3000
actcaggcac caacttcagc tccggctgtg gctccaactc cagctccaac tccaactcca 3060
gctgtggctc aggctgaggt tcctgcaagt ccagctaccg gtcctggacc acatcgtttg 3120
tctataccaa gtttgacctg caatccagac aaaacagatg ggcctgtgtt ccactccaat 3180
actctggaaa gaaaaactcc cattcagatc ctgggacaag agcctgatgc agagatggtg 3240
gaatatctca tctaaacggc caaatcaaga gctgcagatt atcagcaaaa atgcttttaa 3300
tcattttccc ccttttattg gttcttgttt tgagggtgag gacaagggtt gtggggaggg 3360
gatgtttttt aacaggactt tttattggaa caatgtacta cttgagtaat accatgtgaa 3420
caccagtcta ttttggtatg cttagggagt acctctaaag acagattaat cagaatgtgc 3480
tctaaagctt attgtttgaa tttatacgaa tactgggact gttaacaggt ggctatacat 3540
cgacgttttc aatgtgctta aatttgttta aattttccat attctagatc attttttatt 3600
gaagagcaca gtatgtgtgg aagacagtgt ataacacgta gtttggaagt gggaagctag 3660
agagaattga gtgtgtgctg ttttgtatag ttactatcct gtgcagcagc tggagaaagc 3720
actcacctca ggcttacaaa agggaatagt ttcaggagct atgtaagctg gaaaaaaggt 3780
agggagtttt ggggtgcaga agggtactgg agctaatttt ttcttccagt ttcccagcta 3840
ccctgcccca gggaattgtg tttgtcttca tttcagtggt gctttggaaa tggattcttt 3900
tggttccctc ctggaggttc atacattcat atatatgctc tggagtaatt tatgcatttg 3960
gataattaat atattgcttt cagatgctgg gagagtacat taactgagtg atgcgcaact 4020
tcctctctct tagggaatta gaccatcaga ggccttgatg gagagttgca tggggtgcta 4080
tatgcagact tccatggttt gtgtgtagcc atgaacacag cttgcttgca tttagtaaga 4140
ccaatcagct tagtgtttat ttcttctaca gcacagattc actggctggg tctccagtct 4200
caaattgcca atcatttgca aagtgaggaa ggatctttgt tgacaggttg aatgctttga 4260
atttctggtg actactttga aataacttgt tttgtttgtc aaattctaag catatgtctt 4320
aaaaggcatt tttgactatc acctccaagg gaatagcttg agaaacccaa agtactatgc 4380
tgcagtcggg ggagaggtgg attgcagcag tatcctcaac tacctcttct cactgtcagt 4440
gacaccatct tggaatacct ttgggaagca gcaggaaatg tgcatgtggg tagagatcaa 4500
aggaggcaat ggctccaagc cttgccatag ggctgcctcc aaggacacag aaggatgcca 4560
gttgccacag gtccctgccc tgtgtcacct gtctgccctt cattaaggtg agaaatctgc 4620
agatagcatc attaagatca gttttaaggg gtatagggag ggtgagggaa gtggggggtg 4680
ttaggtaagg gttgggggta gaggttttgg gatgtcttag ttagaaacca gattaataga 4740
agagtaggcc tgatatatta catcatgagc catagtggtg ggaaagaact ttagcaatat 4800
agccctacct cctcatttta gtgatgagga atctgagaac tggagaggtt cagtgacttt 4860
ttgaaagtca tacaacacag ctaaccatta tgccaatcac catgcttatt ttgggaaact 4920
ctttatcttt tttaaattcc attttatgaa aaggcatctt catggtccag ggaatatgta 4980
tcttgtaaaa tgtacctggt tggagtagct tgtccagtct tgacaaacta ctgaatttct 5040
gtcttgcctc tccttcagtg ccttttaaaa ggttttccct tttctgatct gcatttcaac 5100
atagagtcac ataaatgtcc ccctgagaaa ccaatcccac ttctttctag gagattgggt 5160
atcttagata atcttttggg gttcctctgt gagtatagga atggtatcct tcctaattat 5220
cttccaaagg aattattttg tgtgtgtgcc tgtgtgtgtg tagagacata aaggagggtg 5280
atgtgatttt cagctagtcc tttcacattt tcaataatga ggtaatcatg ttacatacac 5340
attagtcctc agttataaag tgaatctcag atagaaatta aaagtgcagt tgtgttaaga 5400
ctctttcata ctacccttta gtcataagga gaaaaaaaca ctcaaatagt agaagcagca 5460
agtagcaaac ttcaggagag ctactttcta tccaaataat ttaaaaaaca cttttcacct 5520
actcctttca tggttataac acattggcag actttttgct ggctctggga gccatgattt 5580
taatcacatt ctgcaaggtg acaaatgtca tacattccac attgtgtggt agccatctct 5640
ttagactcat gtgttttggg gaaaggaaga agttcttggc tgagtactat tttgaacttt 5700
ccagaaccct ctcacaccag agacagttct tctctgttca gtttccaatc cccgataatt 5760
tgctaaaata acattgtaca tccaagagag ggaagaagag tatgtcagta tattatgcag 5820
aagatagata cagccttttc agaagatctc cactagtttt tgttccaaaa attcaagttt 5880
atgggagaaa tctcaattag ccaccttttc acagttgtgt ggatataaca tttgggggat 5940
ctttctggac tcctacctat ctgtgcattt taccggcacc tcaggaaagg agggtgacca 6000
ggttgtctta gcttgtactg cttggtgatc tctgaggacc ttctaattca gttgtacccc 6060
agtgttccat gtatagaaaa acttcattag aacaaacttt acttgatatg aaactcctat 6120
taacagtctt tttttgaaat aaaaagtagc ttgagctttc ttttaaaatc atgtatcttg 6180
attgttgatt taatgaagga tttcctttta atgctgcttt tgagcttcaa ggtaatagga 6240
cagcaggaac ctaaaatatc tgccatcatc tgccatagga aagataccca gagacccatc 6300
atgttctctt tttgttgtta cactgttggg tgggtataac aattggaaaa tgaacaaact 6360
gattgattgt gcaaactact ttttatgaca agcctaaacc ctcataatgc ggcagcttaa 6420
agtgtataca tatgcactaa ctttgatcaa ttatattctc atatctgtta gctacacagt 6480
ctcctattat ctcaattgct tatgtgcata tggaatatgt tacttaaaac gtgtgcattc 6540
ttactgaaaa tgttttcaaa ggaaggtatc agctgtgggc taattgccac caatttcagc 6600
ctgccacgat tcttggaaat atgtcttcca agtgccatcc atcatcagta ggacaagtgt 6660
cgggagtttg tttatttttt tccagtagca acgatgggtt acatggagcc atgaaacctc 6720
cttctggcct cccttgtgat taatggcatg tgtttgtaaa atggatagct ggggttggca 6780
gatggctaga gaagaatcgc ctttggttta aaatgtatgt ggtcccctaa tgattgtgac 6840
cccattctgt aatcaactga gctagttcca ataaagttaa gcaggtttaa atccactttg 6900
tgcctatctt ttcactgaca ataaagttag ctattttaaa atgca                 6945


<210> 26
<211> 1084
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Asn Ser Glu Glu Gln Pro Ser Gly Gly Thr Thr Val Leu Gln
 1               5                  10                  15      
Arg Leu Leu Gln Glu Gln Leu Arg Tyr Gly Asn Pro Ser Glu Asn Arg
            20                  25                  30          
Ser Leu Leu Ala Ile His Gln Gln Ala Thr Gly Asn Gly Pro Pro Phe
        35                  40                  45              
Pro Ser Gly Ser Gly Asn Pro Gly Pro Gln Ser Asp Val Leu Ser Pro
    50                  55                  60                  
Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro
65                  70                  75                  80  
Gln Gly Gln Glu Ile Gln Ser Glu Asn Leu Ile Met Glu Lys Gln Leu
                85                  90                  95      
Ser Pro Arg Met Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu Glu Ala
            100                 105                 110         
Lys Val Gln Ser Gln Tyr Phe Arg Gly Gln Gln His Ala Ser Val Gly
        115                 120                 125             
Ala Ala Phe Tyr Val Thr Gly Val Thr Asn Gln Lys Met Arg Thr Glu
    130                 135                 140                 
Gly Arg Pro Ser Val Gln Arg Leu Asn Pro Gly Lys Met His Gln Asp
145                 150                 155                 160 
Glu Gly Leu Arg Asp Leu Lys Gln Gly His Val Arg Ser Leu Ser Glu
                165                 170                 175     
Arg Leu Met Gln Met Ser Leu Ala Thr Ser Gly Val Lys Ala His Pro
            180                 185                 190         
Pro Val Thr Ser Ala Pro Leu Ser Pro Pro Gln Pro Asn Asp Leu Tyr
        195                 200                 205             
Lys Asn Pro Thr Ser Ser Ser Glu Phe Tyr Lys Ala Gln Gly Pro Leu
    210                 215                 220                 
Pro Asn Gln His Ser Leu Lys Gly Met Glu His Arg Gly Pro Pro Pro
225                 230                 235                 240 
Glu Tyr Pro Phe Lys Gly Met Pro Pro Gln Ser Val Val Cys Lys Pro
                245                 250                 255     
Gln Glu Pro Gly His Phe Tyr Ser Glu His Arg Leu Asn Gln Pro Gly
            260                 265                 270         
Arg Thr Glu Gly Gln Leu Met Arg Tyr Gln His Pro Pro Glu Tyr Gly
        275                 280                 285             
Ala Ala Arg Pro Ala Gln Asp Ile Ser Leu Pro Leu Ser Ala Arg Asn
    290                 295                 300                 
Ser Gln Pro His Ser Pro Thr Ser Ser Leu Thr Ser Gly Gly Ser Leu
305                 310                 315                 320 
Pro Leu Leu Gln Ser Pro Pro Ser Thr Arg Leu Ser Pro Ala Arg His
                325                 330                 335     
Pro Leu Val Pro Asn Gln Gly Asp His Ser Ala His Leu Pro Arg Pro
            340                 345                 350         
Gln Gln His Phe Leu Pro Asn Gln Ala His Gln Gly Asp His Tyr Arg
        355                 360                 365             
Leu Ser Gln Pro Gly Leu Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln
    370                 375                 380                 
His His His His His His His Gln Gln Gln Gln Gln Gln Gln Pro Gln
385                 390                 395                 400 
Gln Gln Pro Gly Glu Ala Tyr Ser Ala Met Pro Arg Ala Gln Pro Ser
                405                 410                 415     
Ser Ala Ser Tyr Gln Pro Val Pro Ala Asp Pro Phe Ala Ile Val Ser
            420                 425                 430         
Arg Ala Gln Gln Met Val Glu Ile Leu Ser Asp Glu Asn Arg Asn Leu
        435                 440                 445             
Arg Gln Glu Leu Glu Gly Cys Tyr Glu Lys Val Ala Arg Leu Gln Lys
    450                 455                 460                 
Val Glu Thr Glu Ile Gln Arg Val Ser Glu Ala Tyr Glu Asn Leu Val
465                 470                 475                 480 
Lys Ser Ser Ser Lys Arg Glu Ala Leu Glu Lys Ala Met Arg Asn Lys
                485                 490                 495     
Leu Glu Gly Glu Ile Arg Arg Met His Asp Phe Asn Arg Asp Leu Arg
            500                 505                 510         
Glu Arg Leu Glu Thr Ala Asn Lys Gln Leu Ala Glu Lys Glu Tyr Glu
        515                 520                 525             
Gly Ser Glu Asp Thr Arg Lys Thr Ile Ser Gln Leu Phe Ala Lys Asn
    530                 535                 540                 
Lys Glu Ser Gln Arg Glu Lys Glu Lys Leu Glu Ala Glu Leu Ala Thr
545                 550                 555                 560 
Ala Arg Ser Thr Asn Glu Asp Gln Arg Arg His Ile Glu Ile Arg Asp
                565                 570                 575     
Gln Ala Leu Ser Asn Ala Gln Ala Lys Val Val Lys Leu Glu Glu Glu
            580                 585                 590         
Leu Lys Lys Lys Gln Val Tyr Val Asp Lys Val Glu Lys Met Gln Gln
        595                 600                 605             
Ala Leu Val Gln Leu Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu
    610                 615                 620                 
His Arg Leu Arg Thr Arg Leu Glu Arg Glu Leu Glu Ser Leu Arg Ile
625                 630                 635                 640 
Gln Gln Arg Gln Gly Asn Cys Gln Pro Thr Asn Val Ser Glu Tyr Asn
                645                 650                 655     
Ala Ala Ala Leu Met Glu Leu Leu Arg Glu Lys Glu Glu Arg Ile Leu
            660                 665                 670         
Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu Glu Glu
        675                 680                 685             
Asn Val Met Arg His Phe Ala Leu Asp Ala Ala Ala Thr Val Ala Ala
    690                 695                 700                 
Gln Arg Asp Thr Thr Val Ile Ser His Ser Pro Asn Thr Ser Tyr Asp
705                 710                 715                 720 
Thr Ala Leu Glu Ala Arg Ile Gln Lys Glu Glu Glu Glu Ile Leu Met
                725                 730                 735     
Ala Asn Lys Arg Cys Leu Asp Met Glu Gly Arg Ile Lys Thr Leu His
            740                 745                 750         
Ala Gln Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu Gln Gln Arg
        755                 760                 765             
Ser Arg Lys Glu Pro Ser Lys Thr Glu Gln Leu Ser Cys Met Arg Pro
    770                 775                 780                 
Ala Lys Ser Leu Met Ser Ile Ser Asn Ala Gly Ser Gly Leu Leu Ser
785                 790                 795                 800 
His Ser Ser Thr Leu Thr Gly Ser Pro Ile Met Glu Glu Lys Arg Asp
                805                 810                 815     
Asp Lys Ser Trp Lys Gly Ser Leu Gly Ile Leu Leu Gly Gly Asp Tyr
            820                 825                 830         
Arg Ala Glu Tyr Val Pro Ser Thr Pro Ser Pro Val Pro Pro Ser Thr
        835                 840                 845             
Pro Leu Leu Ser Ala His Ser Lys Thr Gly Ser Arg Asp Cys Ser Thr
    850                 855                 860                 
Gln Thr Glu Arg Gly Thr Glu Ser Asn Lys Thr Ala Ala Val Ala Pro
865                 870                 875                 880 
Ile Ser Val Pro Ala Pro Val Ala Ala Ala Ala Thr Ala Ala Ala Ile
                885                 890                 895     
Thr Ala Thr Ala Ala Thr Ile Thr Thr Thr Met Val Ala Ala Ala Pro
            900                 905                 910         
Val Ala Val Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Pro Ser
        915                 920                 925             
Pro Ala Thr Ala Ala Ala Thr Ala Ala Ala Val Ser Pro Ala Ala Ala
    930                 935                 940                 
Gly Gln Ile Pro Ala Ala Ala Ser Val Ala Ser Ala Ala Ala Val Ala
945                 950                 955                 960 
Pro Ser Ala Ala Ala Ala Ala Ala Val Gln Val Ala Pro Ala Ala Pro
                965                 970                 975     
Ala Pro Val Pro Ala Pro Ala Leu Val Pro Val Pro Ala Pro Ala Ala
            980                 985                 990         
Ala Gln Ala Ser Ala Pro Ala Gln Thr Gln Ala Pro Thr Ser Ala Pro
        995                 1000                1005            
Ala Val Ala Pro Thr Pro Ala Pro Thr Pro Thr Pro Ala Val Ala Gln
    1010                1015                1020                
Ala Glu Val Pro Ala Ser Pro Ala Thr Gly Pro Gly Pro His Arg Leu
1025                1030                1035               1040 
Ser Ile Pro Ser Leu Thr Cys Asn Pro Asp Lys Thr Asp Gly Pro Val
                1045                1050                1055    
Phe His Ser Asn Thr Leu Glu Arg Lys Thr Pro Ile Gln Ile Leu Gly
            1060                1065                1070        
Gln Glu Pro Asp Ala Glu Met Val Glu Tyr Leu Ile
        1075                1080                

<210> 27
<211> 3046
<212> DNA
<213> Homo sapiens

<400> 27
agtcacgtga catgaggaga ggtgggcggg tacctggagg aagctcgcgg cgtcggtggc 60
ggtggcgcgc ggcggccgct gagaccgggg ctttgagtcg caccccgcgg cccgcccccc 120
gccgccaccc tcgcagatcc gtgctttttc ccctttgctt ctctcccgta ctgggtcagt 180
cctgtccgcg ctcgcgcgtc ggtttgcggg tgtgcgcagg cgcggcaggg gccattagcc 240
ctttgggtgg gcggtggagc ccgggagcgc gcgggcgaga ccatggcggg tagcagcact 300
gggggcggtg gggttgggga gacgaaggtg atttaccacc tggatgagga agagactccc 360
tacctggtga agatccctgt ccccgccgag cgcatcaccc tcggcgattt caagagcgtc 420
ctgcagcggc ccgcgggcgc caagtacttt ttcaagtcta tggatcagga tttcggggtg 480
gtgaaggaag aaatttcaga tgacaacgcc cgcctcccct gcttcaacgg aagggtggta 540
tcctggctgg tgtcctcaga taatccccaa cccgagatgg cccctccagt ccatgagcct 600
cgggcagaac tggcgcctcc agccccacct ttacctcctt tgccacccga gaggaccagc 660
ggcattgggg actcaaggcc tccatccttc caccctaatg tgtccagcag ccatgagaat 720
ctggagcctg agacagaaac cgagtcagta gtgtcactga ggcgggagcg gcctcgcagg 780
agagacagca gtgagcatgg cgctgggggc cacaggactg gtggcccctc aaggctggag 840
cgccacctgg ccggatacga gagctcctct accctcatga ccagcgagct ggagagtacc 900
agcctggggg actcggacga ggaggacacc atgagcaggt tcagcagctc cacggagcag 960
agcagtgcct cccgcctcct taagcgccac cggcggcgaa ggaagcagag gccaccccgc 1020
ctggagagga cgtcatcctt cagcagcgtc acagattcca caatgtctct caatatcatc 1080
acagtcacgc taaacatgga gaagtacaac ttcctgggta tctccattgt tggccagagc 1140
aatgagcggg gagacggagg catctacatt ggctccatca tgaagggtgg ggctgtggcg 1200
gccgacgggc gcattgagcc aggggacatg cttttgcagg tgaatgacat gaactttgag 1260
aacatgagca acgatgacgc tgtgcgggtg ctgagggaca ttgtgcacaa gcctggcccc 1320
attgtgctga ctgtggccaa gtgctgggat ccctctcctc aggcctattt cactctcccc 1380
cgaaatgagc ccatccagcc aattgaccct gctgcctggg tgtcccattc cgcggctctg 1440
actggcacct tcccagccta tccaggttcc tcctccatga gcaccattac atctggatcg 1500
tctttgcctg atggctgtga aggccggggt ctctccgtcc atacggacat ggcatcggtg 1560
accaaggcca tggcagctcc agagtctgga ctggaagtcc gggaccgcat gtggctcaag 1620
atcaccatcc ctaatgcctt tctgggctcg gatgtggttg actggctcta ccatcacgtg 1680
gagggctttc ctgagcggcg ggaggcccgc aagtatgcca gcgggctgct caaagcaggc 1740
ctgatccgac acaccgtcaa caagatcacc ttctctgagc agtgctatta cgtcttcgga 1800
gacctcagtg gtggctgtga gagctaccta gtcaacctgt ctctcaatga caacgatggc 1860
tccagtgggg cttcagacca ggataccctg gctcctctgc ctggggccac cccctggccc 1920
ctgctgccca ctttctccta ccaataccct gccccacacc cctacagccc gcagcctcca 1980
ccctaccatg agctttcatc ttacacctat ggtgggggca gtgccagcag ccagcatagt 2040
gagggcagcc ggagcagtgg gtcgacacgg agtgatgggg gggcagggcg cacggggagg 2100
cccgaggagc gggcccccga gtccaagtcc ggcagtggca gtgagtctga gccctccagc 2160
cgagggggca gccttcggcg gggtggggaa gcaagtggga ctagcgatgg gggccctcct 2220
ccatccagag gctcaactgg gggtgcccct aatctccgag cccacccagg gctccatccc 2280
tatggaccgc cccctggcat ggccctcccc tacaacccca tgatggtggt catgatgccc 2340
ccacctccac ctccagtccc tccagcagtg cagcctccgg gggcccctcc agtcagagac 2400
ctgggctctg tgcccccaga actgacagcc agccgccaaa gcttccacat ggccatgggc 2460
aatcccagcg agttctttgt ggatgttatg tagcccactg tggggccagg ctgggccggg 2520
cgctcctggt gtgtgactgg gtgtcctggc cgtcatgtgc ttgctcttac agtgcctggg 2580
ctcagcctac cagctgctgc catacaggag attgtggcca ctgtgactct caccagcagt 2640
gcctggttcc tcccccttcc ctcaggggta gacaagggac ctttgattat ttttagcttt 2700
gtttttttat aagccttttt gggggttaaa atagagtttc ttacattttt gggacttttt 2760
taataggcat ttcctctttt atatgaagaa ttcccatcca ttgggcccct tctaacccca 2820
gaatgtgacc tcctcctcca gttacccaca gccctgccct ttgcagggtt gggggtggtc 2880
agcggtaccc cggggttagg catcctagac agcagcctga ggaagctggg agatttgggc 2940
catgtagctg cctttgttac tctatttatt ttagtcactt gtataaaaca ccaaataaag 3000
caatagaggc aaactcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                3046

<210> 28
<211> 736
<212> PRT
<213> Hono sapiens

<400> 28
Met Ala Gly Ser Ser Thr Gly Gly Gly Gly Val Gly Glu Thr Lys Val
 1               5                  10                  15      
Ile Tyr His Leu Asp Glu Glu Glu Thr Pro Tyr Leu Val Lys Ile Pro
            20                  25                  30          
Val Pro Ala Glu Arg Ile Thr Leu Gly Asp Phe Lys Ser Val Leu Gln
        35                  40                  45              
Arg Pro Ala Gly Ala Lys Tyr Phe Phe Lys Ser Met Asp Gln Asp Phe
    50                  55                  60                  
Gly Val Val Lys Glu Glu Ile Ser Asp Asp Asn Ala Arg Leu Pro Cys
65                  70                  75                  80  
Phe Asn Gly Arg Val Val Ser Trp Leu Val Ser Ser Asp Asn Pro Gln
                85                  90                  95      
Pro Glu Met Ala Pro Pro Val His Glu Pro Arg Ala Glu Leu Ala Pro
            100                 105                 110         
Pro Ala Pro Pro Leu Pro Pro Leu Pro Pro Glu Arg Thr Ser Gly Ile
        115                 120                 125             
Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ser Ser Ser His
    130                 135                 140                 
Glu Asn Leu Glu Pro Glu Thr Glu Thr Glu Ser Val Val Ser Leu Arg
145                 150                 155                 160 
Arg Glu Arg Pro Arg Arg Arg Asp Ser Ser Glu His Gly Ala Gly Gly
                165                 170                 175     
His Arg Thr Gly Gly Pro Ser Arg Leu Glu Arg His Leu Ala Gly Tyr
            180                 185                 190         
Glu Ser Ser Ser Thr Leu Met Thr Ser Glu Leu Glu Ser Thr Ser Leu
        195                 200                 205             
Gly Asp Ser Asp Glu Glu Asp Thr Met Ser Arg Phe Ser Ser Ser Thr
    210                 215                 220                 
Glu Gln Ser Ser Ala Ser Arg Leu Leu Lys Arg His Arg Arg Arg Arg
225                 230                 235                 240 
Lys Gln Arg Pro Pro Arg Leu Glu Arg Thr Ser Ser Phe Ser Ser Val
                245                 250                 255     
Thr Asp Ser Thr Met Ser Leu Asn Ile Ile Thr Val Thr Leu Asn Met
            260                 265                 270         
Glu Lys Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Glu
        275                 280                 285             
Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala
    290                 295                 300                 
Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val
305                 310                 315                 320 
Asn Asp Met Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val
                325                 330                 335     
Leu Arg Asp Ile Val His Lys Pro Gly Pro Ile Val Leu Thr Val Ala
            340                 345                 350         
Lys Cys Trp Asp Pro Ser Pro Gln Ala Tyr Phe Thr Leu Pro Arg Asn
        355                 360                 365             
Glu Pro Ile Gln Pro Ile Asp Pro Ala Ala Trp Val Ser His Ser Ala
    370                 375                 380                 
Ala Leu Thr Gly Thr Phe Pro Ala Tyr Pro Gly Ser Ser Ser Met Ser
385                 390                 395                 400 
Thr Ile Thr Ser Gly Ser Ser Leu Pro Asp Gly Cys Glu Gly Arg Gly
                405                 410                 415     
Leu Ser Val His Thr Asp Met Ala Ser Val Thr Lys Ala Met Ala Ala
            420                 425                 430         
Pro Glu Ser Gly Leu Glu Val Arg Asp Arg Met Trp Leu Lys Ile Thr
        435                 440                 445             
Ile Pro Asn Ala Phe Leu Gly Ser Asp Val Val Asp Trp Leu Tyr His
    450                 455                 460                 
His Val Glu Gly Phe Pro Glu Arg Arg Glu Ala Arg Lys Tyr Ala Ser
465                 470                 475                 480 
Gly Leu Leu Lys Ala Gly Leu Ile Arg His Thr Val Asn Lys Ile Thr
                485                 490                 495     
Phe Ser Glu Gln Cys Tyr Tyr Val Phe Gly Asp Leu Ser Gly Gly Cys
            500                 505                 510         
Glu Ser Tyr Leu Val Asn Leu Ser Leu Asn Asp Asn Asp Gly Ser Ser
        515                 520                 525             
Gly Ala Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro Gly Ala Thr Pro
    530                 535                 540                 
Trp Pro Leu Leu Pro Thr Phe Ser Tyr Gln Tyr Pro Ala Pro His Pro
545                 550                 555                 560 
Tyr Ser Pro Gln Pro Pro Pro Tyr His Glu Leu Ser Ser Tyr Thr Tyr
                565                 570                 575     
Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly Ser Arg Ser Ser
            580                 585                 590         
Gly Ser Thr Arg Ser Asp Gly Gly Ala Gly Arg Thr Gly Arg Pro Glu
        595                 600                 605             
Glu Arg Ala Pro Glu Ser Lys Ser Gly Ser Gly Ser Glu Ser Glu Pro
    610                 615                 620                 
Ser Ser Arg Gly Gly Ser Leu Arg Arg Gly Gly Glu Ala Ser Gly Thr
625                 630                 635                 640 
Ser Asp Gly Gly Pro Pro Pro Ser Arg Gly Ser Thr Gly Gly Ala Pro
                645                 650                 655     
Asn Leu Arg Ala His Pro Gly Leu His Pro Tyr Gly Pro Pro Pro Gly
            660                 665                 670         
Met Ala Leu Pro Tyr Asn Pro Met Met Val Val Met Met Pro Pro Pro
        675                 680                 685             
Pro Pro Pro Val Pro Pro Ala Val Gln Pro Pro Gly Ala Pro Pro Val
    690                 695                 700                 
Arg Asp Leu Gly Ser Val Pro Pro Glu Leu Thr Ala Ser Arg Gln Ser
705                 710                 715                 720 
Phe His Met Ala Met Gly Asn Pro Ser Glu Phe Phe Val Asp Val Met
                725                 730                 735     

<210> 29
<211> 7533
<212> DNA
<213> Homo sapiens

<400> 29
gcgacgctca cgaacgatca gagctgcggg cgacgcaacg aagcccggag gccgcaggct 60
gcgcgctccc tcgcagcagc cgggcgggca aaagccccca gtcctcggcc cccgcgcaag 120
cgacgccggg aaatgcccac atccgggaaa cctgcagcgg agtgcggcgg cggcgacact 180
gagtggaagg caaaatggcg gcggcggcgg cggtggcctg gtgttaaggg gagagccagg 240
tcctcacgac ccctgggacg ggccgcgctg gcccgcggca gcccccccgt tcgtctcccc 300
gctctgcccc accagggata cttggggttg ctgggacgga ctctggccgc ctcagcgtcc 360
gccctcaggc ccgtggccgc tgtccaggag ctctgctctc ccctccagag ttaattattt 420
atattgtaaa gaattttaac agtcctgggg acttccttga aggatcattt tcacttttgc 480
tcagaagaaa gctctggatc tatcaaataa agaagtcctt cgtgtgggct acatatatag 540
atgttttcat gaagaggagt gaaaagccag aaggatatag acaaatgagg cctaagacct 600
ttcctgccag taactatact gtcagtagcc ggcaaatgtt acaagaaatt cgggaatccc 660
ttaggaattt atctaaacca tctgatgctg ctaaggctga gcataacatg agtaaaatgt 720
caaccgaaga tcctcgacaa gtcagaaatc cacccaaatt tgggacgcat cataaagcct 780
tgcaggaaat tcgaaactct ctgcttccat ttgcaaatga aacaaattct tctcggagta 840
cttcagaagt taatccacaa atgcttcaag acttgcaagc tgctggattt gatgaggata 900
tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca 960
ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac 1020
ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct 1080
ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg 1140
tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat 1200
ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac 1260
caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc 1320
caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt 1380
ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag 1440
agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga 1500
gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat 1560
ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga 1620
tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc 1680
tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt 1740
cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata 1800
acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt 1860
ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca 1920
taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta 1980
attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg 2040
tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt 2100
cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt 2160
caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac 2220
cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta 2280
agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg 2340
aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta 2400
ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag 2460
catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc 2520
tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc 2580
aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg 2640
ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg 2700
aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa 2760
agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg 2820
ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt 2880
tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg 2940
gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa 3000
gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc 3060
gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg 3120
attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg 3180
aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag 3240
ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg 3300
cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg 3360
ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa 3420
cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca 3480
gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca 3540
agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg 3600
acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa 3660
attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa 3720
atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat 3780
ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg 3840
aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca 3900
caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt 3960
aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt 4020
atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat 4080
tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa 4140
aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa 4200
agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata 4260
tgctaaataa ttttaaaata caagagtttt tgaaattttt ttgaaagaca gttttagttt 4320
tatcttgctt taaccaaata tgaaacatac cccctatttt acagagctct tttttcccct 4380
cataaccttg tttttggtag aaaataagct agagaaatta agccatcgtg ttggtgagtg 4440
ttcctaggct aatgataatc tgtataattc acatcctgaa actaaggaat acagggttga 4500
aaaaatatta atatgtttgt cagaaggaaa aataatgcat ttatcttccc ccccaccccc 4560
cgccccatgg aatatttaat ctatttaatc ttcttgcatt tatttctcaa gaattactgg 4620
ctttaaaaga agccaaagca ctactagctt tttttccata ttggtatttt tgatgctgct 4680
tccaatttta aaagggaaca aagctgccat aaatcgaaat gttcaatact aaaagctaaa 4740
atatttctca ccatcctaag cagataatta ttttaatttt catatacttt tcctgtatag 4800
taactatttt gattatatca tcaatgttac ctgtttcctc tttcagaaca gtgctgcata 4860
tacagattgt tattggcaaa ggaaaatctg gctatctggc aatattttac ctaagcgcag 4920
attaattggt gaaaaaatta actcttaaga tggccattaa taattaggaa agtttacaga 4980
gtggtcttag tagaaaattc aagtcctcct aatttattta aggttcaata atgcgttcaa 5040
catgcctgtt atgtataacg cttaggttct aaggaagatt aaggtttcat accaaaatac 5100
atgtagctta tcttttagga aggggaaaaa ggctccattt tgaccatagt aaaatttgtg 5160
ttgtgtttta tttccttttc ttaagctcca ctgataaggg attgttttta tcaaaagtta 5220
ctatttgtag attggaggca taattttagt gattttcata cttttagctt tcttcgcata 5280
aaagctaatt gaaaccgtat atgtagtaaa attaaaggca gagctgttgc agttgaattg 5340
gagagttagg gcaaagaaca cttattagcc cacacttccc acctttctac aggtggtcct 5400
ttcagagctc agcctgaaaa cccactactg tgttatcgtg cgtcttttgg ggttagtggt 5460
tcttttgaga atctgaagga agctgtggac tcttcctaga aaaaaaaacc acacatacac 5520
atacaatgtt gcatgcagtt tcaagggatt ttggacatat tgaaacctat cacaggctgt 5580
aggttatgga cctctgtgcc atgagaaaat tgatacatta aactaagaac tttgttttta 5640
acttaccaat cactactcag cacatcttat ataagctgat aatttgtgat ggaaaaggtc 5700
tgtagcatgt gatataaggt gaccttatga atgcctctct tgctggtaca ttaagttgtt 5760
ttaatatatc atttggaggg gactgaaatg ttaggctcat tacaagcttg atacagaaat 5820
atttctgaag gatttctaat cagaattgta aaacaatgtg ctatcatgaa atcgcagtct 5880
tcacctcatg gttcatggaa catttggtta gtcccataaa atcctatgca aaacaaagta 5940
gttcaagaat ttttaggtgg gtagtcacat ttataaggta ttcctcttac tctttgggct 6000
ttttcagtct gatttattta aattttcatt tagttgtttt acttttggac taaggtgcaa 6060
tacagtagaa gataactttg ttacatttat gttgtaggaa aactaaggtg ctgtctcctc 6120
ccccttccct tcccacaaaa tctgtattcc ccctattgct gaaatgtaac agacactaca 6180
aattttgtat tctttttttg ttttttgttt tgagacaggg tctcactctg tcacccaggc 6240
tggagggcag tggcgcttca cagctcactg catcctcaac cttgggggct cacgcagtcc 6300
tcccgcctca gcctcccaag tagctgggca tgcgccacca agcccagcta atttttgtat 6360
ctttagtaga gatggggttt cgccatgttg cccaggttgg tgtggaattc ctgggctcca 6420
gttatatgcc cacctcagcc tcccaaagtg ctgggattac agacgtgacc caccgcgcct 6480
ggcgcaaata tgtattcttt taaaatttcc tctgatacta taagcttttt gcatttatct 6540
gaagcagtat acatgccttt ggtatcagca attttaacag tttggatata cttatcagct 6600
atcttattcc aaaactacat ctacttcttc cagtatagaa tctggtgctt cctgaccaaa 6660
aagatgagaa aaacaatgtt aaaaatatag atgctttcca ttgaaatgga gtgaaaacat 6720
tggttctata tgttttcttt taaaataatt ttcttattaa aaacttgctg tctttattat 6780
acttaccctt tttatgcata tcaatagtat ttataagatg tgttctataa ttatgtaatt 6840
gtagatactg ttatgcattg tccagtgaca tcataaggca ggccctactg ctgtatcttt 6900
tctaccttct tatttgtaat agaaactata gaatgtatga ctaaaaagtc actttgagat 6960
tgactttttt aaaaagttat taccttctgc tgttgcaaag tgcaaaactg tgagtggaat 7020
tgttttattc tgacttaatg tgttagaaat tagagaatac agtgggagga tttttagaca 7080
ttgctgctgc tgttacccaa ggtattttag ataaaaaatt tttaataaac atccctttgg 7140
tatttaaagt ggaacattta gcctgttcat tttaatctaa agcaaaaagt aatttgggtc 7200
aaaatattgg tatatttgta aagcgcctta atatatccct ttgtggaagg cactacacag 7260
tttactttta tattgtattg tgtatataag tattttgtat taaaattgaa tcagtggcaa 7320
cattaaagtt ttataaaatc atgctttgtt agaaaaagaa ttacagcttt gcaatataac 7380
taattgtttc gcataattct gaatgtaata gatatgaata atcagcctgt gtttttaatg 7440
aacttatttg tattttccca atcattttct ctagtgtaat gtttgctggg ataataaaaa 7500
aaattcaaat ctttcaaaaa aaaaaaaaaa aaa                              7533


<210> 30
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 30
Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys
 1               5                  10                  15      
Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln
            20                  25                  30          
Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala
        35                  40                  45              
Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln
    50                  55                  60                  
Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu
65                  70                  75                  80  
Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg
                85                  90                  95      
Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala
            100                 105                 110         
Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn
        115                 120                 125             
Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln
    130                 135                 140                 
Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn
145                 150                 155                 160 
Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln
                165                 170                 175     
Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro
            180                 185                 190         
Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln
        195                 200                 205             
Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val
    210                 215                 220                 
Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro
225                 230                 235                 240 
Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro
                245                 250                 255     
Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser
            260                 265                 270         
Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile
        275                 280                 285             
Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro
    290                 295                 300                 
Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile
305                 310                 315                 320 
Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser
                325                 330                 335     
Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly
            340                 345                 350         
Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val
        355                 360                 365             
Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln
    370                 375                 380                 
Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr
385                 390                 395                 400 
Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser
                405                 410                 415     
His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn
            420                 425                 430         
Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly
        435                 440                 445             
His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser
    450                 455                 460                 
Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln
465                 470                 475                 480 
Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln
                485                 490                 495     
Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu
            500                 505                 510         
Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln
        515                 520                 525             
Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro
    530                 535                 540                 
Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro
545                 550                 555                 560 
Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile
                565                 570                 575     
Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu
            580                 585                 590         
Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys
        595                 600                 605             
Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu
    610                 615                 620                 
Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys
625                 630                 635                 640 
Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln
                645                 650                 655     
Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Gly
            660                 665                 670         
Leu Ser Gln Asp Ala Gln Asp Gln Met Arg Lys Met Leu Cys Gln Lys
        675                 680                 685             
Glu Ser Asn Tyr Ile Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met
    690                 695                 700                 
Phe Val Lys Ile Lys Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys
705                 710                 715                 720 
Leu Ala Arg Lys Val Asp Thr Lys Ala Leu Tyr Ala Thr Lys Thr Leu
                725                 730                 735     
Arg Lys Lys Asp Val Leu Leu Arg Asn Gln Val Ala His Val Lys Ala
            740                 745                 750         
Glu Arg Asp Ile Leu Ala Glu Ala Asp Asn Glu Trp Val Val Arg Leu
        755                 760                 765             
Tyr Tyr Ser Phe Gln Asp Lys Asp Asn Leu Tyr Phe Val Met Asp Tyr
    770                 775                 780                 
Ile Pro Gly Gly Asp Met Met Ser Leu Leu Ile Arg Met Gly Ile Phe
785                 790                 795                 800 
Pro Glu Ser Leu Ala Arg Phe Tyr Ile Ala Glu Leu Thr Cys Ala Val
                805                 810                 815     
Glu Ser Val His Lys Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp
            820                 825                 830         
Asn Ile Leu Ile Asp Arg Asp Gly His Ile Lys Leu Thr Asp Phe Gly
        835                 840                 845             
Leu Cys Thr Gly Phe Arg Trp Thr His Asp Ser Lys Tyr Tyr Gln Ser
    850                 855                 860                 
Gly Asp His Pro Arg Gln Asp Ser Met Asp Phe Ser Asn Glu Trp Gly
865                 870                 875                 880 
Asp Pro Ser Ser Cys Arg Cys Gly Asp Arg Leu Lys Pro Leu Glu Arg
                885                 890                 895     
Arg Ala Ala Arg Gln His Gln Arg Cys Leu Ala His Ser Leu Val Gly
            900                 905                 910         
Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Leu Arg Thr Gly Tyr Thr
        915                 920                 925             
Gln Leu Cys Asp Trp Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu
    930                 935                 940                 
Val Gly Gln Pro Pro Phe Leu Ala Gln Thr Pro Leu Glu Thr Gln Met
945                 950                 955                 960 
Lys Val Ile Asn Trp Gln Thr Ser Leu His Ile Pro Pro Gln Ala Lys
                965                 970                 975     
Leu Ser Pro Glu Ala Ser Asp Leu Ile Ile Lys Leu Cys Arg Gly Pro
            980                 985                 990         
Glu Asp Arg Leu Gly Lys Asn Gly Ala Asp Glu Ile Lys Ala His Pro
        995                 1000                1005            
Phe Phe Lys Thr Ile Asp Phe Ser Ser Asp Leu Arg Gln Gln Ser Ala
    1010                1015                1020                
Ser Tyr Ile Pro Lys Ile Thr His Pro Thr Asp Thr Ser Asn Phe Asp
1025                1030                1035               1040 
Pro Val Asp Pro Asp Lys Leu Trp Ser Asp Asp Asn Glu Glu Glu Asn
                1045                1050                1055    
Val Asn Asp Thr Leu Asn Gly Trp Tyr Lys Asn Gly Lys His Pro Glu
            1060                1065                1070        
His Ala Phe Tyr Glu Phe Thr Phe Arg Arg Phe Phe Asp Asp Asn Gly
        1075                1080                1085            
Tyr Pro Tyr Asn Tyr Pro Lys Pro Ile Glu Tyr Glu Tyr Ile Asn Ser
    1090                1095                1100                
Gln Gly Ser Glu Gln Gln Ser Asp Glu Asp Asp Gln Asn Thr Gly Ser
1105                1110                1115               1120 
Glu Ile Lys Asn Arg Asp Leu Val Tyr Val
                1125                1130

<210> 31
<211> 5581
<212> DNA
<213> Homo sapiens

<400> 31
attcccgtgc cctagtttag cgacgtgtgg ggggtttggc tttctcttct gatgtaagct 60
cacctgcgct tagctcccca gccggactct ggagatgggg attctgacat cattcacatc 120
ttgccatcac atccttcagc ccaactccag aacttctggg gagctttccc tcggggatgg 180
agtgcggcct ggagcaaacc cgtttgtgaa atgcaagtct ccagtgtccc gagggttggg 240
aacggggggc gaggcgagga atggaccctg aagaagagag tgataatctt caaaatgaag 300
actttggaaa attttaggtt ctctatagga actacaaaaa tggaaggaaa gaacattttc 360
aaaaggaaat tattttgaaa gtatgtttac aacaaactga tactattgac agtttttttt 420
tttaaataat aaaacacttt aagaagattg tatttatggt aaaaggaaac tggactaaca 480
atgaggccaa agacttttcc tgccacgact tattctggaa atagccggca gcgactgcaa 540
gagattcgtg aggggttaaa acagccatcc aagtcttcgg ttcaggggct acccgcagga 600
ccaaacagtg acacttccct ggatgccaaa gtcctgggga gcaaagatgc caccaggcag 660
cagcagcaga tgagagccac cccaaagttc ggaccttatc agaaagcctt gagggaaatc 720
agatattcct tgttgccttt tgctaatgaa tcgggcacct ctgcagctgc agaagtgaac 780
cggcaaatgc tgcaggaact ggtgaacgca ggatgcgacc aggagatggc tggccgagct 840
ctcaagcaga ctggcagcag gagcatcgag gccgccctgg agtacatcag caagatgggc 900
tacctggacc cgaggaatga gcagattgtg cgggtcatta agcagacctc cccaggaaag 960
gggctcatgc caaccccagt gacgcggagg cccagcttcg aaggaaccgg cgattcgttt 1020
gcgtcctacc accagctgag cggtaccccc tacgagggcc caagcttcgg cgctgacggc 1080
cccacggcgc tggaggagat gccgcggccg tacgtggact accttttccc cggagtcggc 1140
ccccacgggc ccggccacca gcaccagcac ccacccaagg gctacggtgc cagcgtagag 1200
gcagcagggg cacacttccc gctgcagggc gcgcactacg ggcggccgca cctgctggtg 1260
cctggggaac ccctgggcta cggagtgcag cgcagcccct ccttccagag caagacgccg 1320
ccggagaccg ggggttacgc cagcctgccc acgaagggcc agggaggacc gccaggcgcc 1380
ggcctcgctt tcccaccccc tgccgccggg ctctacgtgc cgcacccaca ccacaagcag 1440
gccggtcccg cggcccacca gctgcatgtg ctgggctccc gcagccaggt gttcgccagc 1500
gacagccccc cgcagagcct gctcactccc tcgcggaaca gcctcaacgt ggacctgtat 1560
gaattgggca gcacctccgt ccagcagtgg ccggctgcca ccctggcccg ccgggactcc 1620
ctgcagaagc cgggcctgga ggcgccgccg cgcgcgcacg tggccttccg gcctgactgc 1680
ccagtgccca gcaggaccaa ctccttcaac agccaccagc cgcggcccgg tccgcctggc 1740
aaggccgagc cctccctgcc cgcccccaac accgtgacgg ctgtcacggc cgcgcacatc 1800
ttgcacccgg tgaagagcgt gcgtgtgctg aggccggagc cgcagacggc tgtggggccc 1860
tcgcaccccg cctgggtgcc cgcgcctgcc ccggcccccg cccccgcccc cgccccggct 1920
gcggagggct tggacgccaa ggaggagcat gccctggcgc tgggcggcgc aggcgccttc 1980
ccgctggacg tggagtacgg aggcccagac cggaggtgcc cgcctccgcc ctacccgaag 2040
cacctgctgc tgcgcagcaa gtcggagcag tacgacctgg acagcctgtg cgcaggcatg 2100
gagcagagcc tccgtgcggg ccccaacgag cccgagggcg gcgacaagag ccgcaaaagc 2160
gccaaggggg acaaaggcgg aaaggataaa aagcagattc agacctctcc cgttcccgtc 2220
cgcaaaaaca gcagagacga agagaagaga gagtcacgca tcaagagcta ctcgccatac 2280
gcctttaagt tcttcatgga gcagcacgtg gagaatgtca tcaaaaccta ccagcagaag 2340
gttaaccgga ggctgcagct ggagcaagaa atggccaaag ctggactctg tgaagctgag 2400
caggagcaga tgcggaagat cctctaccag aaagagtcta attacaacag gttaaagagg 2460
gccaagatgg acaagtctat gtttgtcaag atcaaaaccc tggggatcgg tgcctttgga 2520
gaagtgtgcc ttgcttgtaa ggtggacact cacgccctgt acgccatgaa gaccctaagg 2580
aaaaaggatg tcctgaaccg gaatcaggtg gcccacgtca aggccgagag ggacatcctg 2640
gccgaggcag acaatgagtg ggtggtcaaa ctctactact ccttccaaga caaagacagc 2700
ctgtactttg tgatggacta catccctggt ggggacatga tgagcctgct gatccggatg 2760
gaggtcttcc ctgagcacct ggcccggttc tacatcgcag agctgacttt ggccattgag 2820
agtgtccaca agatgggctt catccaccga gacatcaagc ctgataacat tttgatagat 2880
ctggatggtc acattaaact cacagatttc ggcctctgca ctgggttcag gtggactcac 2940
aattccaaat attaccagaa agggagccat gtcagacagg acagcatgga gcccagcgac 3000
ctctgggatg atgtgtctaa ctgtcggtgt ggggacaggc tgaagaccct agagcagagg 3060
gcgcggaagc agcaccagag gtgcctggca cattcactgg tggggactcc aaactacatc 3120
gcacccgagg tgctcctccg caaagggtac actcaactct gtgactggtg gagtgttgga 3180
gtgattctct tcgagatgct ggtggggcag ccgccctttt tggcacctac tcccacagaa 3240
acccagctga aggtgatcaa ctgggagaac acgctccaca ttccagccca ggtgaagctg 3300
agccctgagg ccagggacct catcaccaag ctgtgctgct ccgcagacca ccgcctgggg 3360
cggaatgggg ccgatgacct gaaggcccac cccttcttca gcgccattga cttctccagt 3420
gacatccgga agcagccagc cccctacgtt cccaccatca gccaccccat ggacacctcg 3480
aatttcgacc ccgtagatga agaaagccct tggaacgatg ccagcgaagg tagcaccaag 3540
gcctgggaca cactcacctc gcccaataac aagcatcctg agcacgcatt ttacgaattc 3600
accttccgaa ggttctttga tgacaatggc tacccctttc gatgcccaaa gccttcagga 3660
gcagaagctt cacaggctga gagctcagat ttagaaagct ctgatctggt ggatcagact 3720
gaaggctgcc agcctgtgta cgtgtagatg ggggccaggc acccccacca ctcgctgcct 3780
cccaggtcag ggtcccggag ccggtgccct cacaggccaa tagggaagcc gagggctgtt 3840
ttgttttaaa ttagtccgtc gattacttca cttgaaattc tgctcttcac caagaaaacc 3900
caaacaggac acttttgaaa acaggactca gcatcgcttt caataggctt ttcaggacct 3960
tcactgcatt aaaacaatat ttttgaaaat ttagtacagt ttagaaagag cacttatttt 4020
gtttatatcc attttttctt actaaattat agggattaac tttgacaaat catgctgctg 4080
ttattttcta catttgtatt ttatccatag cacttattca catttaggaa aagacataaa 4140
aactgaagaa cattgatgag aaatctctgt gcaataatgt aaaaaaaaaa aaagataaca 4200
ctctgctcaa tgtcacggag accattttat ccacacaatg gtttttgttt tttatttttt 4260
cccatgtttc aaaattgtga tataatgata taatgttaaa agctgctttt tttggctttt 4320
tgcatatcta gtataatagg aagtgtgagc aaggtgatga tgtggctgtg atttccgacg 4380
tctggtgtgt ggagagtact gcatgagcag agttcttcta ttataaaatt accatatctt 4440
gccattcaca gcaggtcctg tgaatacgtt tttactgagt gtctttaaat gaggtgttct 4500
agacagtgtg ctgataatgt attgtgcggg tgacctcttc gctatgattg tatctcttac 4560
tgttttgtta aagaaatgca gatgtgtaac tgagaagtga tttgtgtgtg tgtcttggtt 4620
gtgattggat tctttggggg gggggaactg aaacatttgt catatactga acttatatac 4680
atcaaaaggg attaatacag cgatgccaaa aagtttaatc acggacacat gtccgtttct 4740
gtagtccgta tgctctttca ttcttggtag agctggtatg tggaatgcca tacctctgac 4800
cctactactt acctttttac tgacagactg cccacactga aagcttcagt gaatgttctt 4860
agtcctgttt tcttctgtta ctgtcaggaa actgagtgat ctaatggttc tctcactttt 4920
tttttgttct tttagtgtac tttgaagtat caaatcttaa cttggtttaa acaatacata 4980
ttcctaacct ttgtaaaaaa gcaaagattc ttcaaaatga cattgaaata aaaagtaagc 5040
catacgtatt ttcttagaag tatagatgta tgtgcgtgta tacacacaca cacacacaca 5100
cagagataaa cacaatattc cttatttcaa attagtatga ttcctattta aagtgattta 5160
tatttgagta aaaagttcaa ttcttttttg ctttttaaaa aatctgatgc ttcataattt 5220
tcattatatt attccacata tttttccttg aagttcttag cataatgtat ccattactta 5280
gtatatatct aggcaacaac acttagaagt ttatcagtgt ttaaactaaa aaaataaaga 5340
ttcctgtgta ctggtttaca tttgtgtgag tggcatactc aagtctgctg tgcctgtcgt 5400
cgtgactgtc agtattctcg ctattttata gtcgtgccat gttgttactc acagcgctct 5460
gacatacttt catgtggtag gttctttctc aggaactcag tttaactatt atttattgat 5520
atatcattac ctttgaaaag cttctactgg cacaatttat tattaaaatt ttgaatccaa 5580
a                                                                 5581


<210> 32
<211> 1088
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Pro Lys Thr Phe Pro Ala Thr Thr Tyr Ser Gly Asn Ser Arg
 1               5                  10                  15      
Gln Arg Leu Gln Glu Ile Arg Glu Gly Leu Lys Gln Pro Ser Lys Ser
            20                  25                  30          
Ser Val Gln Gly Leu Pro Ala Gly Pro Asn Ser Asp Thr Ser Leu Asp
        35                  40                  45              
Ala Lys Val Leu Gly Ser Lys Asp Ala Thr Arg Gln Gln Gln Gln Met
    50                  55                  60                  
Arg Ala Thr Pro Lys Phe Gly Pro Tyr Gln Lys Ala Leu Arg Glu Ile
65                  70                  75                  80  
Arg Tyr Ser Leu Leu Pro Phe Ala Asn Glu Ser Gly Thr Ser Ala Ala
                85                  90                  95      
Ala Glu Val Asn Arg Gln Met Leu Gln Glu Leu Val Asn Ala Gly Cys
            100                 105                 110         
Asp Gln Glu Met Ala Gly Arg Ala Leu Lys Gln Thr Gly Ser Arg Ser
        115                 120                 125             
Ile Glu Ala Ala Leu Glu Tyr Ile Ser Lys Met Gly Tyr Leu Asp Pro
    130                 135                 140                 
Arg Asn Glu Gln Ile Val Arg Val Ile Lys Gln Thr Ser Pro Gly Lys
145                 150                 155                 160 
Gly Leu Met Pro Thr Pro Val Thr Arg Arg Pro Ser Phe Glu Gly Thr
                165                 170                 175     
Gly Asp Ser Phe Ala Ser Tyr His Gln Leu Ser Gly Thr Pro Tyr Glu
            180                 185                 190         
Gly Pro Ser Phe Gly Ala Asp Gly Pro Thr Ala Leu Glu Glu Met Pro
        195                 200                 205             
Arg Pro Tyr Val Asp Tyr Leu Phe Pro Gly Val Gly Pro His Gly Pro
    210                 215                 220                 
Gly His Gln His Gln His Pro Pro Lys Gly Tyr Gly Ala Ser Val Glu
225                 230                 235                 240 
Ala Ala Gly Ala His Phe Pro Leu Gln Gly Ala His Tyr Gly Arg Pro
                245                 250                 255     
His Leu Leu Val Pro Gly Glu Pro Leu Gly Tyr Gly Val Gln Arg Ser
            260                 265                 270         
Pro Ser Phe Gln Ser Lys Thr Pro Pro Glu Thr Gly Gly Tyr Ala Ser
        275                 280                 285             
Leu Pro Thr Lys Gly Gln Gly Gly Pro Pro Gly Ala Gly Leu Ala Phe
    290                 295                 300                 
Pro Pro Pro Ala Ala Gly Leu Tyr Val Pro His Pro His His Lys Gln
305                 310                 315                 320 
Ala Gly Pro Ala Ala His Gln Leu His Val Leu Gly Ser Arg Ser Gln
                325                 330                 335     
Val Phe Ala Ser Asp Ser Pro Pro Gln Ser Leu Leu Thr Pro Ser Arg
            340                 345                 350         
Asn Ser Leu Asn Val Asp Leu Tyr Glu Leu Gly Ser Thr Ser Val Gln
        355                 360                 365             
Gln Trp Pro Ala Ala Thr Leu Ala Arg Arg Asp Ser Leu Gln Lys Pro
    370                 375                 380                 
Gly Leu Glu Ala Pro Pro Arg Ala His Val Ala Phe Arg Pro Asp Cys
385                 390                 395                 400 
Pro Val Pro Ser Arg Thr Asn Ser Phe Asn Ser His Gln Pro Arg Pro
                405                 410                 415     
Gly Pro Pro Gly Lys Ala Glu Pro Ser Leu Pro Ala Pro Asn Thr Val
            420                 425                 430         
Thr Ala Val Thr Ala Ala His Ile Leu His Pro Val Lys Ser Val Arg
        435                 440                 445             
Val Leu Arg Pro Glu Pro Gln Thr Ala Val Gly Pro Ser His Pro Ala
    450                 455                 460                 
Trp Val Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala
465                 470                 475                 480 
Ala Glu Gly Leu Asp Ala Lys Glu Glu His Ala Leu Ala Leu Gly Gly
                485                 490                 495     
Ala Gly Ala Phe Pro Leu Asp Val Glu Tyr Gly Gly Pro Asp Arg Arg
            500                 505                 510         
Cys Pro Pro Pro Pro Tyr Pro Lys His Leu Leu Leu Arg Ser Lys Ser
        515                 520                 525             
Glu Gln Tyr Asp Leu Asp Ser Leu Cys Ala Gly Met Glu Gln Ser Leu
    530                 535                 540                 
Arg Ala Gly Pro Asn Glu Pro Glu Gly Gly Asp Lys Ser Arg Lys Ser
545                 550                 555                 560 
Ala Lys Gly Asp Lys Gly Gly Lys Asp Lys Lys Gln Ile Gln Thr Ser
                565                 570                 575     
Pro Val Pro Val Arg Lys Asn Ser Arg Asp Glu Glu Lys Arg Glu Ser
            580                 585                 590         
Arg Ile Lys Ser Tyr Ser Pro Tyr Ala Phe Lys Phe Phe Met Glu Gln
        595                 600                 605             
His Val Glu Asn Val Ile Lys Thr Tyr Gln Gln Lys Val Asn Arg Arg
    610                 615                 620                 
Leu Gln Leu Glu Gln Glu Met Ala Lys Ala Gly Leu Cys Glu Ala Glu
625                 630                 635                 640 
Gln Glu Gln Met Arg Lys Ile Leu Tyr Gln Lys Glu Ser Asn Tyr Asn
                645                 650                 655     
Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met Phe Val Lys Ile Lys
            660                 665                 670         
Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys Leu Ala Cys Lys Val
        675                 680                 685             
Asp Thr His Ala Leu Tyr Ala Met Lys Thr Leu Arg Lys Lys Asp Val
    690                 695                 700                 
Leu Asn Arg Asn Gln Val Ala His Val Lys Ala Glu Arg Asp Ile Leu
705                 710                 715                 720 
Ala Glu Ala Asp Asn Glu Trp Val Val Lys Leu Tyr Tyr Ser Phe Gln
                725                 730                 735     
Asp Lys Asp Ser Leu Tyr Phe Val Met Asp Tyr Ile Pro Gly Gly Asp
            740                 745                 750         
Met Met Ser Leu Leu Ile Arg Met Glu Val Phe Pro Glu His Leu Ala
        755                 760                 765             
Arg Phe Tyr Ile Ala Glu Leu Thr Leu Ala Ile Glu Ser Val His Lys
    770                 775                 780                 
Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp Asn Ile Leu Ile Asp
785                 790                 795                 800 
Leu Asp Gly His Ile Lys Leu Thr Asp Phe Gly Leu Cys Thr Gly Phe
                805                 810                 815     
Arg Trp Thr His Asn Ser Lys Tyr Tyr Gln Lys Gly Ser His Val Arg
            820                 825                 830         
Gln Asp Ser Met Glu Pro Ser Asp Leu Trp Asp Asp Val Ser Asn Cys
        835                 840                 845             
Arg Cys Gly Asp Arg Leu Lys Thr Leu Glu Gln Arg Ala Arg Lys Gln
    850                 855                 860                 
His Gln Arg Cys Leu Ala His Ser Leu Val Gly Thr Pro Asn Tyr Ile
865                 870                 875                 880 
Ala Pro Glu Val Leu Leu Arg Lys Gly Tyr Thr Gln Leu Cys Asp Trp
                885                 890                 895     
Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu Val Gly Gln Pro Pro
            900                 905                 910         
Phe Leu Ala Pro Thr Pro Thr Glu Thr Gln Leu Lys Val Ile Asn Trp
        915                 920                 925             
Glu Asn Thr Leu His Ile Pro Ala Gln Val Lys Leu Ser Pro Glu Ala
    930                 935                 940                 
Arg Asp Leu Ile Thr Lys Leu Cys Cys Ser Ala Asp His Arg Leu Gly
945                 950                 955                 960 
Arg Asn Gly Ala Asp Asp Leu Lys Ala His Pro Phe Phe Ser Ala Ile
                965                 970                 975     
Asp Phe Ser Ser Asp Ile Arg Lys Gln Pro Ala Pro Tyr Val Pro Thr
            980                 985                 990         
Ile Ser His Pro Met Asp Thr Ser Asn Phe Asp Pro Val Asp Glu Glu
        995                 1000                1005            
Ser Pro Trp Asn Asp Ala Ser Glu Gly Ser Thr Lys Ala Trp Asp Thr
    1010                1015                1020                
Leu Thr Ser Pro Asn Asn Lys His Pro Glu His Ala Phe Tyr Glu Phe
1025                1030                1035               1040 
Thr Phe Arg Arg Phe Phe Asp Asp Asn Gly Tyr Pro Phe Arg Cys Pro
                1045                1050                1055    
Lys Pro Ser Gly Ala Glu Ala Ser Gln Ala Glu Ser Ser Asp Leu Glu
            1060                1065                1070        
Ser Ser Asp Leu Val Asp Gln Thr Glu Gly Cys Gln Pro Val Tyr Val
        1075                1080                1085            

<210> 33
<211> 7091
<212> DNA
<213> Homo sapiens

<400> 33
gctacccact tccgccccct ccccctgcca ttggaactag ctgagccgaa ctagttgcgg 60
ccaccgagca gccggctctc ggcacctcct cctccgcctc cctgtctcct gttccattcg 120
cctttcctct tctttcctgg cccacgccgc tccgaggcct cgcgaccgcc gagcctgcag 180
cctgccccgc ggccaacatg agcttcttgt tgagttctca gcctgaagtt gactggaact 240
ttcagttaac aagtatttat cgaatacctg atctgtagtg ttggacttag acctatggaa 300
ggagctactg atgtgaatga aagtggtagt cgctcttcta aaacttttaa accaaagaag 360
aacattccag agggttctca ccagtatgag ctcttaaaac acgcagaagc cacacttggc 420
agtggcaacc ttcggatggc tgtcatgctt cctgaagggg aagatctcaa tgaatgggtt 480
gcagttaaca ctgtggattt cttcaatcag atcaacatgc tttatggaac tatcacagac 540
ttctgtacag aagagagttg tccagtgatg tcagctggcc caaaatatga gtatcattgg 600
gcagatggaa cgaacataaa gaaacctatt aagtgctctg caccaaagta tattgattac 660
ttgatgactt gggttcagga ccagttggat gatgagacgt tatttccatc aaaaattggt 720
gtcccgttcc caaagaattt catgtctgtg gcaaaaacta tactcaaacg cctctttagg 780
gtttatgctc acatttatca tcagcatttt gaccctgtga tccagcttca ggaggaagca 840
catctaaata catctttcaa gcactttatt ttttttgtcc aggaattcaa ccttattgat 900
agaagagaac ttgcaccact ccaagaactg attgaaaaac tcacctcaaa agacagataa 960
aaggatgcag agctgtgcaa attgttcctc aaatgaagca gtgtggagtg tattggggat 1020
tttgttatat tttgttttta tctggattgt ttttgtccta ggtttggggg cgggggcttg 1080
tttgggttcc tttttcttta ttctgattat gtgaaaccat attctattgc taggggaagc 1140
caagaaccat tctctataca cttgataagg gtaaatttat cttagtgttt ttaaacttgg 1200
ttttggttac ttgaggagtt ttttaataat attgtgtgct gcaagaaagt gcttgttgat 1260
tgaactgccg atggattggt ttctgtgtgg tataaattgt ggcccattta tgaagtcccc 1320
aaaagagtta tgtttttaag tgccttggca ggctcacttc tgaggtgcaa aacatagata 1380
tagaactgaa cagggcttga aacaatatta ggattactac ccagggcact tactggtgca 1440
tgttgtaaca tatctatgat aaaagccata gtttacctaa aatggtgatt tccagccttt 1500
actgctttga agaaacagaa tttgtaaagg tatgcatgta gaacataaaa aatatttctt 1560
aattattttt tatattgatg gtaatatatt acgttcaaca atgcttaaag ctctacaagc 1620
aggtcttttc ccacctcttg atatctgtga tactgaaact tgaggatgtt gaaatgtatt 1680
acattttggc ttctttctac atgttaactg cactgtagat gtaaaaattc aggttatata 1740
taggattgcc atcttcagag gtgatgctga actgtgaggt ttcctagtaa ttgccaaatg 1800
agccgtaagt ctgcagaatt cccttctact ttgaagagaa ggggatagga atgtatattt 1860
ggctgggggc atggagatgt tcgtatgtat gaggagttag ggatggggag tcaagttcta 1920
gaaagttttg tctgaaaacc tttgaataga atggcatgaa gattttaatc aattacttat 1980
aaacaaagtc ttagagactt ccttttagga atcaacttcc atgagaagtt aaaaataaat 2040
tattaatttt aggtacagac attaaacatg gaatttaagg actgttgggg gaaattgatc 2100
acttcttagc atttccattc agtgaatgga gctgatgttt gcctgtcatt ttaagatgat 2160
accatacctt ctttggttat tataggtcca gtttgaagca ttctgacttc tggtttttcc 2220
accctgaaag gaaatgtttt tctttgcagc agtattagat aatgaaaaat gctaattcag 2280
tagttattaa cttctaaatt ttattcgcca tgactttcta gtgaattatt accataaata 2340
acaatttcag aaacttagtt tttagaataa atattaattt ttccacttca gttttattct 2400
agaaaatacc ctttttagaa atccagtttt agttttgtca ttttcgataa atctttcttc 2460
agttagaaat atatatcctt ccttcagttg aaacatatac ctttttcaca tctaggaaga 2520
aatgcttgct ctgaaatagt atagattaaa aacactcagt agaaaagaat ctaaaattaa 2580
atgaatttgt tttgccatta aagtagagca gtgatacaat ttaatgccat tacaattatg 2640
ttgactagaa actgcctttt tctccacttc atttctagca attatttacc aagtaccaac 2700
agtagaagta acaggaaagc ctggcagagt taaatatctt ggacatttat tggtaaagct 2760
tatttataaa ctgcagtcag agctagttaa tttccttaaa tctttttgta ttcagataga 2820
taatatgaat cattatgggt tgattcagaa ataaaatttg tgaggtgatt ttgaatcttg 2880
tccatatagg aaaatgaagc acagaattac tcagtcttcc atattgtatt tgacttcata 2940
tcaatctagt aaaaaaggag ttgcaatagc caagtataga gagaatagtg aaaaattaat 3000
cttgcccttt caagccttat acagtagtac actgtacttg tttttagtag taagacctac 3060
tttcccacta tatgtagata gtttgttttc actgtgccag aatctcaggt gcctgcttag 3120
agtatttctt taatcacagt cactgggaag taaggagatg tatatatgtg tatatatggt 3180
aacaaagcat agcagttctc taggggagag gcctggcatt gcacatggtg ttacatggct 3240
acaagtaagg aaaaaatcag aaagtgaaag aactgatgta ataaaaggtt gatttggttg 3300
gttcccatga aagttagtaa gatgcccttt taaatataag gatcagtgct ttgttctgca 3360
gcagagtttg ctgataaatg tctgttggat tctttttgga tttctttaat taatttgtaa 3420
gtaaccaaga taattatttt cccccttgct ctctatatta atacgtagct ataaagcaac 3480
agttggtttt cttatccttt gataaaagca tcccataaaa tataaagtag taagttaaca 3540
tagtattatt gtcacacaca atgctttttt tggttaaatg ttgatacgaa gcaatgtttt 3600
ggaattactt taattgatgg agtagtggtg gtagagagaa attaataaca aaaagagtga 3660
aaatatttta attagcagta gatggtgcta ctggctttca tttgctgact tgattattcc 3720
ctttctctta aaaaccatgg cattagactg cactaaatta acaagcatgt tagttgctgg 3780
tagaggtttt ggaggttaat ttaccttaaa ttggaagact tttaattgca gtctctttct 3840
accttccctc tgttagtcat ttgtaaattc taaatggtca ccataaaatg tattaggtag 3900
gagaagatac gttttatgta taatatatct cagactgagt tactgcctgt cttatcagga 3960
tggataaaac actacagtct cttatcagga aatagagatg atgtggatat ttatatatta 4020
catatataac caccagactc cattttatat attagcattt tccttgctta tgggaaaata 4080
gcaaaacaac atttcattta tacttttgtt tacccctctc tgagacaggt tttgataacc 4140
actgaaatgg tagaatatgt gagatacaaa tattgagttg tagaactttc tttttaaggt 4200
gaataagtca tgccttaaca tccaaataag agttcatctt cagagtggtt cttttgggag 4260
cactgtttat tccagctata ctgcaaaagt ataatgtttt tggaactgtt ctagagcata 4320
ccatgaaaag cagtttgtta ttatgcagga aaatcagttt catcatttta gttacactaa 4380
acacttttgg cagcttaata tgaccttttt aaattttttt tatttttttt atttttattt 4440
ctttaagatg gagtcttgct ctgttgcccg ggctggagta caatggcatg atctcagctc 4500
actgcaacct ccacctcctg ggttcaagca tttctcctgc ctcagcctcc caagtagctg 4560
ggattacagg cagcaccaca cctggctaat tttcatattt ttagtagaga tggggtttca 4620
acatattggc caggctggtc tcaaactcct gacctcaagt gatccgccct ccccagcctc 4680
ccaaagtgct gggattacag gtgtgagcca ccacagccag ccagtatgac ctatcttaat 4740
catcagctca actgtaattt aaatttggct gttctctgga gctaaaccat tagggaagtt 4800
caaaggaatg tgccatgatt tccgaatttg cacaagagaa tgttttaagc attggtagca 4860
taattgaata aaagaatagt ttcctgatgt cactattttg aagtggaaat tatcacttgg 4920
atgtggaggt tttacttttt aaaaacattc agcttaatta ccttacctta attaccttag 4980
ttagatatac taatggaaaa aaaccaagtc ctttctctag aacttgtttt ctatttttgt 5040
tccttttcat gaaaacttct caatttaatt ttaactactg taggatagta ttgattgaat 5100
ggatactatg gaaaagtgga tccaatattt aagatagaag tagtttaagg agacaacagc 5160
ctttactgcc attttttttt aaatgttttc actcagatga acaatttgac tttaataaaa 5220
gactggagat ttttgtacaa agaaatagga ataagtttca tatactaatt atgctgagtt 5280
ttaagcctac atatcacaaa atatttagaa ttgtataacc ttttcatata tttataactt 5340
ttaatgtctt tttaaaagat gtgggaccaa aaatatattt ataatttgga aatgtgactg 5400
cataccaata agaaaactta ccttattttg aaatttatct gggatattaa agaatctacc 5460
aattcttaaa aacacagatt tatactttaa gcttatttta aaattaaaga atatatacca 5520
attcttagaa acactttaag gactactctt aaataactta aatatcagag ttttgttgta 5580
atattaaaat ttaccgtgga aatcactgtt gttcagctat caccttaatt gtgtatgata 5640
tgataaatgt ttagcagtaa agctatctta agatttaatg gaaaagttta atttgaagat 5700
gtaacaaaaa ttctgaccac agttgattct gaatttttaa ggctttccta ataggctgat 5760
cacagagaat aatccatttt gaaggtataa aactgcactg tatgtctgtc acttgtagct 5820
gaactgattc acattttgac aaaagagaga aaatacaaaa atgagttttg caaatgtaat 5880
aactttttct gcatatagaa ctaaataatt gaaaaatatg ggctatagtt ctcaaaggta 5940
gatagtaaaa tcactggctt tttccagctg tatgtttttc cactgtgcgt gtacacacac 6000
actggaaaat aattaggctg attttgcagg tcttcattgt tagagattct gaagtattta 6060
ctgtcaattc ataggtttca gtttatttag gaaattagtg tttgacagct ttttttaaat 6120
tatttcactg aagctgagat tattagtgat acaaagttaa aatttcaata tttaatttct 6180
ctatatatta ttaatattaa attgtttttt acttataaat tcatgttctc atctgattta 6240
atattaaatt tgtataggtg ggcgtttctt accattttgc acaagttttt gtttttctga 6300
aatacttaat tgtgcaggtt gtaaaaaaga ttagtgcatt ttcattttaa ggatgctttg 6360
ctccttaaat tgttcgacag aaatgacttt ttagggaaag tagttttttt ggagctacta 6420
acttgtattt attattgtac atgcataacc agggtggtga gggcactaat cttgtaggaa 6480
acacttactt gatgttttat ttgaactttt cctataggtt taacttttac tgcatagaat 6540
taacactagg aacagtgtca tgaaatctgg gttgaaggag aatacagtat atatgagaac 6600
acttaaagtt caaatagaaa tcatttctga agacaaaagc agaggaatat tgtcagtgcc 6660
aagtaatgga agaataaggg cggcatttac actgtgcaag tattgagaag agtgcataaa 6720
gacagggaac tactctcatg gagacagttt ctctcttata atcaagtaac tagaagggga 6780
aaaatcatct aagttatgaa atccaacata ggcgctatat tacaaactgt gccggattat 6840
gcaaattgta gttgttactg atcaaagttt aattgcttca tttttgttta aaaagggata 6900
ctgatgtcag aaaatctgta atatgtttta ttcaaaagat gtaaataatg tatacagact 6960
tgtatgtgat gggatgggaa atatttaaat tctaggtgtt tttttttttt taaagaagaa 7020
actcaatgtt tataagaaaa aaatgaataa atagttacgt ttggccatga atcctgaaaa 7080
aaaaaaaaaa a                                                      7091


<210> 34
<211> 221
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Gly Ala Thr Asp Val Asn Glu Ser Gly Ser Arg Ser Ser Lys
 1               5                  10                  15      
Thr Phe Lys Pro Lys Lys Asn Ile Pro Glu Gly Ser His Gln Tyr Glu
            20                  25                  30          
Leu Leu Lys His Ala Glu Ala Thr Leu Gly Ser Gly Asn Leu Arg Met
        35                  40                  45              
Ala Val Met Leu Pro Glu Gly Glu Asp Leu Asn Glu Trp Val Ala Val
    50                  55                  60                  
Asn Thr Val Asp Phe Phe Asn Gln Ile Asn Met Leu Tyr Gly Thr Ile
65                  70                  75                  80  
Thr Asp Phe Cys Thr Glu Glu Ser Cys Pro Val Met Ser Ala Gly Pro
                85                  90                  95      
Lys Tyr Glu Tyr His Trp Ala Asp Gly Thr Asn Ile Lys Lys Pro Ile
            100                 105                 110         
Lys Cys Ser Ala Pro Lys Tyr Ile Asp Tyr Leu Met Thr Trp Val Gln
        115                 120                 125             
Asp Gln Leu Asp Asp Glu Thr Leu Phe Pro Ser Lys Ile Gly Val Pro
    130                 135                 140                 
Phe Pro Lys Asn Phe Met Ser Val Ala Lys Thr Ile Leu Lys Arg Leu
145                 150                 155                 160 
Phe Arg Val Tyr Ala His Ile Tyr His Gln His Phe Asp Pro Val Ile
                165                 170                 175     
Gln Leu Gln Glu Glu Ala His Leu Asn Thr Ser Phe Lys His Phe Ile
            180                 185                 190         
Phe Phe Val Gln Glu Phe Asn Leu Ile Asp Arg Arg Glu Leu Ala Pro
        195                 200                 205             
Leu Gln Glu Leu Ile Glu Lys Leu Thr Ser Lys Asp Arg
    210                 215                 220     

<210> 35
<211> 5020
<212> DNA
<213> Homo sapiens

<400> 35
gtgacgcgag gcgggttctt ggactgagtg tgcggcgcgg tgcgccgcct tccgaggctc 60
ctcccgcggg tggcagcgga cggggcgcgc ccctcggcca gtcctcggtc ctcaggcttg 120
tggctccgtt gagcaccggc cgccgggcct ctgggtccgt cgagtggaga ctctctgaaa 180
agcgtgggct ccgtggcctc cggcgcggcc gcggcgggtc ggtctcctag atcatccggg 240
aagcccacgg gaccctcagg cgggcaggat gaacgactgg cacaggatct tcacccaaaa 300
cgtgcttgtc cctccccacc cacagagagc gcgccagcct tggaaggaat ccacggcatt 360
ccagtgtgtc ctcaagtggc tggacggacc ggtaattagg cagggcgtgc tggaggtact 420
gtcagaggtt gaatgccatc tgcgagtgtc tttctttgat gtcacctacc ggcacttctt 480
tgggaggacg tggaaaacca cagtgaagcc gacgaagaga ccgccgtcca ggatcgtctt 540
taatgagccc ttgtattttc acacatccct aaaccaccct catatcgtgg ctgtggtgga 600
agtggtcgct gagggcaaga aacgggatgg gagcctccag acattgtcct gtgggtttgg 660
aattcttcgg atcttcagca accagccgga ctctcctatc tctgcttccc aggacaaaag 720
gttgcggctg taccatggca cccccagagc cctcctgcac ccgcttctcc aggaccccgc 780
agagcaaaac agacacatga ccctcattga gaactgcagc ctgcagtaca cgctgaagcc 840
acacccggcc ctggagcctg cgttccacct tcttcctgag aaccttctgg tgtctggtct 900
gcagcagata cctggcctgc ttccagctca tggagaatcc ggcgacgctc tccgaaagcc 960
tcgcctccag aagcccatca cggggcactt ggatgactta ttcttcaccc tgtacccctc 1020
cctggagaag tttgaggaag agctgctgga gctccacgtc caggaccact tccaggaggg 1080
atgtggccca ctggacggtg gtgccctgga gatcctggag cggcgcctgc gtgtgggcgt 1140
gcacaatggt ctgggcttcg tgcagaggcc gcaggtcgtt gtactggtgc ctgagatgga 1200
tgtggccttg acgcgctcag ctagcttcag caggaaagtg gtctcctctt ccaagaccag 1260
ctccgggagc caagctctgg ttttgagaag ccgcctccgc ctcccagaga tggtcggcca 1320
ccctgcattt gcggtcatct tccagctgga gtacgtgttc agcagccctg caggagtgga 1380
cggcaatgca gcttcggtca cctctctgtc caacctggca tgcatgcaca tggtccgctg 1440
ggctgtttgg aaccccttgc tggaagctga ttctggaagg gtgaccctgc ctctgcaggg 1500
tgggatccag cccaacccct cgcactgtct ggtctacaag gtaccctcag ccagcatgag 1560
ctctgaagag gtgaagcagg tggagtcggg tacactccgg ttccagttct cgctgggctc 1620
agaagaacac ctggatgcac ccacggagcc tgtcagtggc cccaaagtgg agcggcggcc 1680
ttccaggaaa ccacccacgt ccccttcgag cccgccagcg ccagtacctc gagttctcgc 1740
tgccccgcag aactcacctg tgggaccagg gttgtcaatt tcccagctgg cggcctcccc 1800
gcggtccccg actcagcact gcttggccag gcctacttca cagctacccc atggctctca 1860
ggcctccccg gcccaggcac aggagttccc gttggaggcc ggtatctccc acctggaagc 1920
cgacctgagc cagacctccc tggtcctgga aacatccatt gccgaacagt tacaggagct 1980
gccgttcacg cctttgcatg cccctattgt tgtgggaacc cagaccagga gctctgcagg 2040
gcagccctcg agagcctcca tggtgctcct gcagtcctcc ggctttcccg agattctgga 2100
tgccaataaa cagccagccg aggctgtcag cgctacagaa cctgtgacgt ttaaccctca 2160
gaaggaagaa tcagattgtc tacaaagcaa cgagatggtg ctacagtttc ttgcctttag 2220
cagagtggcc caggactgcc gaggaacatc atggccaaag actgtgtatt tcaccttcca 2280
gttctaccgc ttcccacccg caacgacgcc acgactgcag ctggtccagc tggatgaggc 2340
cggccagccc agctctggcg ccctgaccca catcctcgtg cctgtgagca gagatggcac 2400
ctttgatgct gggtctcctg gcttccagct gaggtacatg gtgggccctg ggttcctgaa 2460
gccaggtgag cggcgctgct ttgcccgcta cctggccgtg cagaccctgc agattgacgt 2520
ctgggacgga gactccctgc tgctcatcgg atctgctgcc gtccagatga agcatctcct 2580
ccgccaaggc cggccggctg tgcaggcctc ccacgagctt gaggtcgtgg caactgaata 2640
cgagcaggac aacatggtgg tgagtggaga catgctgggg tttggccgcg tcaagcccat 2700
cggcgtccac tcggtggtga agggccggct gcacctgact ttggccaacg tgggtcaccc 2760
gtgtgaacag aaagtgagag gttgtagcac attgccaccg tccagatctc gggtcatctc 2820
aaacgatgga gccagccgct tctctggagg cagcctcctc acgactggaa gctcaaggcg 2880
aaaacacgtg gtgcaagcac agaagctggc ggacgtggac agtgagctgg ctgccatgct 2940
actgacccat gcccggcagg gcaaggggcc ccaggacgtc agccgcgagt cggatgccac 3000
ccgcaggcgt aagctggagc ggatgaggtc tgtgcgcctg caggaggccg ggggagactt 3060
gggccggcgc gggacgagcg tgttggcgca gcagagcgtc cgcacacagc acttgcggga 3120
cctacaggtc atcgccgcct accgggaacg cacgaaggcc gagagcatcg ccagcctgct 3180
gagcctggcc atcaccacgg agcacacgct ccacgccacg ctgggggtcg ccgagttctt 3240
tgagtttgtg cttaagaacc cccacaacac acagcacacg gtgactgtgg agatcgacaa 3300
ccccgagctc agcgtcatcg tggacagtca ggagtggagg gacttcaagg gtgctgctgg 3360
cctgcacaca ccggtggagg aggacatgtt ccacctgcgt ggcagcctgg ccccccagct 3420
ctacctgcgc ccccacgaga ccgcccacgt ccccttcaag ttccagagct tctctgcagg 3480
gcagctggcc atggtgcagg cctctcctgg gttgagcaac gagaagggca tggacgccgt 3540
gtcaccttgg aagtccagcg cagtgcccac taaacacgcc aaggtcttgt tccgagcgag 3600
tggtggcaag cccatcgccg tgctctgcct gactgtggag ctgcagcccc acgtggtgga 3660
ccaggtcttc cgcttctatc acccggagct ctccttcctg aagaaggcca tccgcctgcc 3720
gccctggcac acatttccag gtgctccggt gggaatgctt ggtgaggacc ccccagtcca 3780
tgttcgctgc agcgacccga acgtcatctg tgagacccag aatgtgggcc ccggggaacc 3840
acgggacata tttctgaagg tggccagtgg tccaagcccg gagatcaaag acttctttgt 3900
catcatttac tcggatcgct ggctggcgac acccacacag acgtggcagg tctacctcca 3960
ctccctgcag cgcgtggatg tctcctgcgt cgcaggccag ctgacccgcc tgtcccttgt 4020
ccttcggggg acacagacag tgaggaaagt gagagctttc acctctcatc cccaggagct 4080
gaagacagac cccaaaggtg tcttcgtgct gccgcctcgt ggggtgcagg acctgcatgt 4140
tggcgtgagg ccccttaggg ccggcagccg ctttgtccat ctcaacctgg tggacgtgga 4200
ttgccaccag ctggtggcct cctggctcgt gtgcctctgc tgccgccagc cgctcatctc 4260
caaggccttt gagatcatgt tggctgcggg cgaagggaag ggtgtcaaca agaggatcac 4320
ctacaccaac ccctacccct cccggaggac attccacctg cacagcgacc acccggagct 4380
gctgcggttc agagaggact ccttccaggt cgggggtgga gagacctaca ccatcggctt 4440
gcagtttgcg cctagtcaga gagtgggtga ggaggagatc ctgatctaca tcaatgacca 4500
tgaggacaaa aacgaagagg cattttgcgt gaaggtcatc taccagtgag ggcttgaggg 4560
tgacgtcctt cctgcggcac ccagctgggg cctgtctgtg cccctcctgc cctgcaggct 4620
gtcctccccg cctctctgca gcctttcact tcagtgccca cctggctgac ctgtgcactt 4680
ggctgaggaa gcagagaccg agcgctggtc attttgtagt acctgcatcc agcttagctg 4740
ctgctgacac ccagcaggcc tgggttccgt gagcgcgaac tccgtggtgg tgggtctggc 4800
tctggtgctg ccatctacgc atgtgggacc ctcgttatcg ctgttgctca aaatgtattt 4860
tatgaatcat cctaaatgag aaaattatgt ttttcttact ggattttgta caaacataat 4920
ctattatttg ctatgcaata ttttatgctg gtattatatc tgttttttaa attgttgaac 4980
aaaatactaa acttttacac gtcttcaaaa aaaaaaaaaa                       5020


<210> 36
<211> 1426
<212> PRT
<213> Homo sapiens

<400> 36
Met Asn Asp Trp His Arg Ile Phe Thr Gln Asn Val Leu Val Pro Pro
 1               5                  10                  15      
His Pro Gln Arg Ala Arg Gln Pro Trp Lys Glu Ser Thr Ala Phe Gln
            20                  25                  30          
Cys Val Leu Lys Trp Leu Asp Gly Pro Val Ile Arg Gln Gly Val Leu
        35                  40                  45              
Glu Val Leu Ser Glu Val Glu Cys His Leu Arg Val Ser Phe Phe Asp
    50                  55                  60                  
Val Thr Tyr Arg His Phe Phe Gly Arg Thr Trp Lys Thr Thr Val Lys
65                  70                  75                  80  
Pro Thr Lys Arg Pro Pro Ser Arg Ile Val Phe Asn Glu Pro Leu Tyr
                85                  90                  95      
Phe His Thr Ser Leu Asn His Pro His Ile Val Ala Val Val Glu Val
            100                 105                 110         
Val Ala Glu Gly Lys Lys Arg Asp Gly Ser Leu Gln Thr Leu Ser Cys
        115                 120                 125             
Gly Phe Gly Ile Leu Arg Ile Phe Ser Asn Gln Pro Asp Ser Pro Ile
    130                 135                 140                 
Ser Ala Ser Gln Asp Lys Arg Leu Arg Leu Tyr His Gly Thr Pro Arg
145                 150                 155                 160 
Ala Leu Leu His Pro Leu Leu Gln Asp Pro Ala Glu Gln Asn Arg His
                165                 170                 175     
Met Thr Leu Ile Glu Asn Cys Ser Leu Gln Tyr Thr Leu Lys Pro His
            180                 185                 190         
Pro Ala Leu Glu Pro Ala Phe His Leu Leu Pro Glu Asn Leu Leu Val
        195                 200                 205             
Ser Gly Leu Gln Gln Ile Pro Gly Leu Leu Pro Ala His Gly Glu Ser
    210                 215                 220                 
Gly Asp Ala Leu Arg Lys Pro Arg Leu Gln Lys Pro Ile Thr Gly His
225                 230                 235                 240 
Leu Asp Asp Leu Phe Phe Thr Leu Tyr Pro Ser Leu Glu Lys Phe Glu
                245                 250                 255     
Glu Glu Leu Leu Glu Leu His Val Gln Asp His Phe Gln Glu Gly Cys
            260                 265                 270         
Gly Pro Leu Asp Gly Gly Ala Leu Glu Ile Leu Glu Arg Arg Leu Arg
        275                 280                 285             
Val Gly Val His Asn Gly Leu Gly Phe Val Gln Arg Pro Gln Val Val
    290                 295                 300                 
Val Leu Val Pro Glu Met Asp Val Ala Leu Thr Arg Ser Ala Ser Phe
305                 310                 315                 320 
Ser Arg Lys Val Val Ser Ser Ser Lys Thr Ser Ser Gly Ser Gln Ala
                325                 330                 335     
Leu Val Leu Arg Ser Arg Leu Arg Leu Pro Glu Met Val Gly His Pro
            340                 345                 350         
Ala Phe Ala Val Ile Phe Gln Leu Glu Tyr Val Phe Ser Ser Pro Ala
        355                 360                 365             
Gly Val Asp Gly Asn Ala Ala Ser Val Thr Ser Leu Ser Asn Leu Ala
    370                 375                 380                 
Cys Met His Met Val Arg Trp Ala Val Trp Asn Pro Leu Leu Glu Ala
385                 390                 395                 400 
Asp Ser Gly Arg Val Thr Leu Pro Leu Gln Gly Gly Ile Gln Pro Asn
                405                 410                 415     
Pro Ser His Cys Leu Val Tyr Lys Val Pro Ser Ala Ser Met Ser Ser
            420                 425                 430         
Glu Glu Val Lys Gln Val Glu Ser Gly Thr Leu Arg Phe Gln Phe Ser
        435                 440                 445             
Leu Gly Ser Glu Glu His Leu Asp Ala Pro Thr Glu Pro Val Ser Gly
    450                 455                 460                 
Pro Lys Val Glu Arg Arg Pro Ser Arg Lys Pro Pro Thr Ser Pro Ser
465                 470                 475                 480 
Ser Pro Pro Ala Pro Val Pro Arg Val Leu Ala Ala Pro Gln Asn Ser
                485                 490                 495     
Pro Val Gly Pro Gly Leu Ser Ile Ser Gln Leu Ala Ala Ser Pro Arg
            500                 505                 510         
Ser Pro Thr Gln His Cys Leu Ala Arg Pro Thr Ser Gln Leu Pro His
        515                 520                 525             
Gly Ser Gln Ala Ser Pro Ala Gln Ala Gln Glu Phe Pro Leu Glu Ala
    530                 535                 540                 
Gly Ile Ser His Leu Glu Ala Asp Leu Ser Gln Thr Ser Leu Val Leu
545                 550                 555                 560 
Glu Thr Ser Ile Ala Glu Gln Leu Gln Glu Leu Pro Phe Thr Pro Leu
                565                 570                 575     
His Ala Pro Ile Val Val Gly Thr Gln Thr Arg Ser Ser Ala Gly Gln
            580                 585                 590         
Pro Ser Arg Ala Ser Met Val Leu Leu Gln Ser Ser Gly Phe Pro Glu
        595                 600                 605             
Ile Leu Asp Ala Asn Lys Gln Pro Ala Glu Ala Val Ser Ala Thr Glu
    610                 615                 620                 
Pro Val Thr Phe Asn Pro Gln Lys Glu Glu Ser Asp Cys Leu Gln Ser
625                 630                 635                 640 
Asn Glu Met Val Leu Gln Phe Leu Ala Phe Ser Arg Val Ala Gln Asp
                645                 650                 655     
Cys Arg Gly Thr Ser Trp Pro Lys Thr Val Tyr Phe Thr Phe Gln Phe
            660                 665                 670         
Tyr Arg Phe Pro Pro Ala Thr Thr Pro Arg Leu Gln Leu Val Gln Leu
        675                 680                 685             
Asp Glu Ala Gly Gln Pro Ser Ser Gly Ala Leu Thr His Ile Leu Val
    690                 695                 700                 
Pro Val Ser Arg Asp Gly Thr Phe Asp Ala Gly Ser Pro Gly Phe Gln
705                 710                 715                 720 
Leu Arg Tyr Met Val Gly Pro Gly Phe Leu Lys Pro Gly Glu Arg Arg
                725                 730                 735     
Cys Phe Ala Arg Tyr Leu Ala Val Gln Thr Leu Gln Ile Asp Val Trp
            740                 745                 750         
Asp Gly Asp Ser Leu Leu Leu Ile Gly Ser Ala Ala Val Gln Met Lys
        755                 760                 765             
His Leu Leu Arg Gln Gly Arg Pro Ala Val Gln Ala Ser His Glu Leu
    770                 775                 780                 
Glu Val Val Ala Thr Glu Tyr Glu Gln Asp Asn Met Val Val Ser Gly
785                 790                 795                 800 
Asp Met Leu Gly Phe Gly Arg Val Lys Pro Ile Gly Val His Ser Val
                805                 810                 815     
Val Lys Gly Arg Leu His Leu Thr Leu Ala Asn Val Gly His Pro Cys
            820                 825                 830         
Glu Gln Lys Val Arg Gly Cys Ser Thr Leu Pro Pro Ser Arg Ser Arg
        835                 840                 845             
Val Ile Ser Asn Asp Gly Ala Ser Arg Phe Ser Gly Gly Ser Leu Leu
    850                 855                 860                 
Thr Thr Gly Ser Ser Arg Arg Lys His Val Val Gln Ala Gln Lys Leu
865                 870                 875                 880 
Ala Asp Val Asp Ser Glu Leu Ala Ala Met Leu Leu Thr His Ala Arg
                885                 890                 895     
Gln Gly Lys Gly Pro Gln Asp Val Ser Arg Glu Ser Asp Ala Thr Arg
            900                 905                 910         
Arg Arg Lys Leu Glu Arg Met Arg Ser Val Arg Leu Gln Glu Ala Gly
        915                 920                 925             
Gly Asp Leu Gly Arg Arg Gly Thr Ser Val Leu Ala Gln Gln Ser Val
    930                 935                 940                 
Arg Thr Gln His Leu Arg Asp Leu Gln Val Ile Ala Ala Tyr Arg Glu
945                 950                 955                 960 
Arg Thr Lys Ala Glu Ser Ile Ala Ser Leu Leu Ser Leu Ala Ile Thr
                965                 970                 975     
Thr Glu His Thr Leu His Ala Thr Leu Gly Val Ala Glu Phe Phe Glu
            980                 985                 990         
Phe Val Leu Lys Asn Pro His Asn Thr Gln His Thr Val Thr Val Glu
        995                 1000                1005            
Ile Asp Asn Pro Glu Leu Ser Val Ile Val Asp Ser Gln Glu Trp Arg
    1010                1015                1020                
Asp Phe Lys Gly Ala Ala Gly Leu His Thr Pro Val Glu Glu Asp Met
1025                1030                1035               1040 
Phe His Leu Arg Gly Ser Leu Ala Pro Gln Leu Tyr Leu Arg Pro His
                1045                1050                1055    
Glu Thr Ala His Val Pro Phe Lys Phe Gln Ser Phe Ser Ala Gly Gln
            1060                1065                1070        
Leu Ala Met Val Gln Ala Ser Pro Gly Leu Ser Asn Glu Lys Gly Met
        1075                1080                1085            
Asp Ala Val Ser Pro Trp Lys Ser Ser Ala Val Pro Thr Lys His Ala
    1090                1095                1100                
Lys Val Leu Phe Arg Ala Ser Gly Gly Lys Pro Ile Ala Val Leu Cys
1105                1110                1115               1120 
Leu Thr Val Glu Leu Gln Pro His Val Val Asp Gln Val Phe Arg Phe
                1125                1130                1135    
Tyr His Pro Glu Leu Ser Phe Leu Lys Lys Ala Ile Arg Leu Pro Pro
            1140                1145                1150        
Trp His Thr Phe Pro Gly Ala Pro Val Gly Met Leu Gly Glu Asp Pro
        1155                1160                1165            
Pro Val His Val Arg Cys Ser Asp Pro Asn Val Ile Cys Glu Thr Gln
    1170                1175                1180                
Asn Val Gly Pro Gly Glu Pro Arg Asp Ile Phe Leu Lys Val Ala Ser
1185                1190                1195               1200 
Gly Pro Ser Pro Glu Ile Lys Asp Phe Phe Val Ile Ile Tyr Ser Asp
                1205                1210                1215    
Arg Trp Leu Ala Thr Pro Thr Gln Thr Trp Gln Val Tyr Leu His Ser
            1220                1225                1230        
Leu Gln Arg Val Asp Val Ser Cys Val Ala Gly Gln Leu Thr Arg Leu
        1235                1240                1245            
Ser Leu Val Leu Arg Gly Thr Gln Thr Val Arg Lys Val Arg Ala Phe
    1250                1255                1260                
Thr Ser His Pro Gln Glu Leu Lys Thr Asp Pro Lys Gly Val Phe Val
1265                1270                1275               1280 
Leu Pro Pro Arg Gly Val Gln Asp Leu His Val Gly Val Arg Pro Leu
                1285                1290                1295    
Arg Ala Gly Ser Arg Phe Val His Leu Asn Leu Val Asp Val Asp Cys
            1300                1305                1310        
His Gln Leu Val Ala Ser Trp Leu Val Cys Leu Cys Cys Arg Gln Pro
        1315                1320                1325            
Leu Ile Ser Lys Ala Phe Glu Ile Met Leu Ala Ala Gly Glu Gly Lys
    1330                1335                1340                
Gly Val Asn Lys Arg Ile Thr Tyr Thr Asn Pro Tyr Pro Ser Arg Arg
1345                1350                1355               1360 
Thr Phe His Leu His Ser Asp His Pro Glu Leu Leu Arg Phe Arg Glu
                1365                1370                1375    
Asp Ser Phe Gln Val Gly Gly Gly Glu Thr Tyr Thr Ile Gly Leu Gln
            1380                1385                1390        
Phe Ala Pro Ser Gln Arg Val Gly Glu Glu Glu Ile Leu Ile Tyr Ile
        1395                1400                1405            
Asn Asp His Glu Asp Lys Asn Glu Glu Ala Phe Cys Val Lys Val Ile
    1410                1415                1420                
Tyr Gln
1425    

<210> 37
<211> 7971
<212> DNA
<213> Homo sapiens

<400> 37
cgggcatgct cagtgggccg ggccggcagg tttgcgtggc cgctgagttg ccggcgccgg 60
ctgagccagc ggacgccgcg ttccttggcg gccgccggtt cccgggaagt tacgtggcga 120
agccggcttc cgaggagacg ccgggaggcc acgggtgctg ctgacgggcg ggcgaccggg 180
cgaggccgac gtggccgggc tgcgaaagct gcgggaggcc gagtgggtgg ccgcgctcgg 240
agggaggtgc cggtcgggcg cgccccgtgg agaagacccg ggcggggcgg gcgcttcccg 300
gacttttgtc cgagttgaat tccctccccc tgggccgggc ccttccggcc gcccccgccc 360
gtgccccgct cgctctcggg agatgtttat ttgggctgtg gcgtgaggag cgggcgggcc 420
agcgccgcgg agtttcgggt ccgaggagcc tcgcgcggcg ctggagagag acaagatgtc 480
cgccagagct gcggccgcca agagcacagc aatggaggaa acagctatat gggaacaaca 540
tacagtgacg cttcacaggg ctcctggatt tggatttgga attgcaatat ctggtggacg 600
agataatcct cattttcaga gtggggaaac gtcaatagtg atttcagatg tgctgaaagg 660
aggaccagct gaaggacagc tacaggaaaa tgaccgagtt gcaatggtta acggagtttc 720
aatggataat gttgaacatg cttttgctgt tcagcaacta aggaaaagtg ggaaaaatgc 780
aaaaattaca attagaagga agaagaaagt tcaaatacca gtaagtcgtc ctgatcctga 840
accagtatct gataatgaag aagatagtta tgatgaggaa atacatgatc caagaagtgg 900
ccggagtggt gtggttaaca gaaggagtga gaagatttgg ccgagggata gaagtgcaag 960
tagagagagg agcttgtccc cgcggtcaga caggcggtca gtggcttcca gccagcctgc 1020
taaacctact aaagtcacac tggtgaaatc ccggaaaaat gaagaatatg gtcttcgatt 1080
ggcaagccat atatttgtta aggaaatttc acaagatagt ttggcagcaa gagatggcaa 1140
tattcaagaa ggtgatgttg tattgaagat aaatggtact gtgacagaaa atatgtcatt 1200
gacagatgca aagacattga tagaaaggtc taaaggcaaa ttaaaaatgg tagttcaaag 1260
agatgaacgg gctacgctat tgaatgtccc tgatctttct gacagcatcc actctgctaa 1320
tgcctctgag agagacgaca tttcagaaat tcagtcactg gcatcagatc attctggtcg 1380
atcacacgat aggcctcccc gccgcagccg gtcacgatct cctgaccagc ggtcagagcc 1440
ttctgatcat tccaggcact cgccgcagca gccaagcaat ggcagtctcc ggagtagaga 1500
tgaagagaga atttctaaac ctggggctgt ctcaactcct gtaaagcatg ctgatgatca 1560
cacacctaaa acagtggaag aagttacagt tgaaagaaat gagaaacaaa caccttctct 1620
tccagaacca aagcctgtgt atgcccaagt tgggcaacca gatgtggatt tacctgtcag 1680
tccatctgat ggtgtcctac ctaattcaac tcatgaagat gggattcttc ggcccagcat 1740
gaaattggta aaattcagaa aaggagatag tgtgggtttg cggctggctg gtggaaatga 1800
tgttggaata tttgtagctg gcgttctaga agatagccct gcagccaagg aaggcttaga 1860
ggaaggtgat caaattctca gggtaaacaa cgtagatttt acaaatatca taagagaaga 1920
agccgtcctt ttcctgcttg acctccctaa aggagaagaa gtgaccatat tggctcagaa 1980
gaagaaggat gtttatcgtc gcattgtaga atcagatgta ggagattctt tctatattag 2040
aacccatttt gaatatgaaa aggaatctcc ctatggactt agttttaaca aaggagaggt 2100
gttccgtgtt gtggatacct tgtacaatgg aaaactgggc tcttggcttg ctattcgaat 2160
tggtaaaaat cataaggagg tagaacgagg catcatccct aataagaaca gagctgagca 2220
gctagccagt gtacagtata cacttccaaa aacagcaggc ggagaccgtg ctgacttctg 2280
gagattcaga ggtcttcgca gctccaagag aaatcttcga aaaagcagag aggatttgtc 2340
cgctcagcct gttcaaacaa agtttccagc ttatgaaaga gtggttcttc gagaagctgg 2400
atttctgagg cctgtaacca tttttggacc aatagctgat gttgccagag aaaagctggc 2460
aagagaagaa ccagatattt atcaaattgc aaagagtgaa ccacgagacg ctggaactga 2520
ccaacgtagc tctggcatta ttcgcctgca tacaataaag caaatcatag atcaagacaa 2580
acatgcttta ttagatgtaa caccaaatgc agttgatcgt cttaactatg cccagtggta 2640
tccaattgtt gtatttctta accctgattc taagcaagga gtaaaaacaa tgagaatgag 2700
gttatgtcca gaatctcgga aaagtgccag gaagttatac gagcgatctc ataaacttcg 2760
taaaaataat caccatcttt ttacaactac aattaactta aattcaatga atgatggttg 2820
gtatggtgcg ctgaaagaag caattcaaca acagcaaaac cagctggtat gggtttccga 2880
gggaaaggcg gatggtgcta caagtgatga ccttgatttg catgatgatc gtctgtccta 2940
cctgtcagct ccaggtagtg aatactcaat gtatagcacg gacagtagac acacttctga 3000
ctatgaagac acagacacag aaggcggggc ctacactgat caagaactag atgaaactct 3060
taatgatgag gttgggactc caccggagtc tgccattaca cggtcctctg agcctgtaag 3120
agaggactcc tctggaatgc atcatgaaaa ccaaacatat cctccttact caccacaagc 3180
gcagccacaa ccaattcata gaatagactc ccctggattt aagccagcct ctcaacagaa 3240
agcagaagct tcatctccag tcccttacct ttcgcctgaa acaaacccag catcatcaac 3300
ctctgctgtt aatcataatg taaatttaac taatgtcaga ctggaggagc ccaccccagc 3360
tccttccacc tcttactcac cacaagctga ttctttaaga acaccaagta ctgaggcagc 3420
tcacataatg ctaagagatc aagaaccatc attgtcgtcg catgtagatc caacaaaggt 3480
gtatagaaag gatccatatc ccgaggaaat gatgaggcag aaccatgttt tgaaacagcc 3540
agccgttagt cacccagggc acaggccaga caaagagcct aatctgacct atgaacccca 3600
actcccatac gtagagaaac aagccagcag agacctcgag cagcccacat acagatacga 3660
gtcctcaagc tatacggacc agttttctcg aaactatgaa catcgtctgc gatacgaaga 3720
tcgcgtcccc atgtatgaag aacagtggtc atattatgat gacaaacagc cctacccatc 3780
tcggccacct tttgataatc agcactctca agaccttgac tccagacagc atcccgaaga 3840
gtcctcagaa cgagggtact ttccacgttt tgaagagcca gcccctctgt cttacgacag 3900
cagaccacgt tacgaacagg cacctagagc atccgccctg cggcacgaag agcagccagc 3960
tcctgggtat gacacacatg gtagactcag accggaagcc cagccccacc cttcagcagg 4020
gcccaagcct gcagagtcca agcagtattt tgagcaatat tcacgcagtt acgagcaagt 4080
accaccccaa ggatttacct ctagagcagg tcattttgag cctctccatg gtgctgcagc 4140
tgtccctccg ctgatacctt catctcagca taagccagaa gctctgcctt caaacaccaa 4200
accactgcct ccacccccaa ctcaaaccga agaagaggaa gatccagcaa tgaagccaca 4260
gtctgtactc accagagtta agatgtttga aaacaaaaga tctgcatcct tagagaccaa 4320
gaaggatgta aatgacactg gcagttttaa gcctccagaa gtagcatcta aaccttcagg 4380
tgctcccatc attggtccca aacccacttc tcagaatcaa ttcagtgaac atgacaaaac 4440
tctgtacagg atcccagaac ctcaaaaacc tcaactgaag ccacctgaag atattgttcg 4500
gtccaatcat tatgaccctg aagaagatga agaatattat cgaaaacagc tgtcatactt 4560
tgaccgaaga agttttgaga ataagcctcc tgcacacatt gccgccagcc atctctccga 4620
gcctgcaaag ccagcgcatt ctcagaatca atcaaatttt tctagttatt cttcaaaggg 4680
aaagcctcct gaagctgatg gtgtggatag atcatttggc gagaaacgct atgaacccat 4740
ccaggccact ccccctcctc ctccattgcc ctcgcagtat gcccagccat ctcagcctgt 4800
caccagcgcg tctctccaca tacattctaa gggagcacat ggtgaaggta attcagtgtc 4860
attggatttt cagaattcct tagtgtccaa accagaccca cctccatctc agaataagcc 4920
agcaactttc agaccaccaa accgagaaga tactgctcag gcagctttct atccccagaa 4980
aagttttcca gataaagccc cagttaatgg aactgaacag actcagaaaa cagtcactcc 5040
agcatacaat cgattcacac caaaaccata tacaagttct gcccgaccat ttgaacgcaa 5100
gtttgaaagt cctaaattca atcacaatct tctgccaagt gaaactgcac ataaacctga 5160
cttgtcttca aaaactccca cttctccaaa aactcttgtg aaatcgcaca gtttggcaca 5220
gcctcctgag tttgacagtg gagttgaaac tttctctatc catgcagaga agcctaaata 5280
tcaaataaat aatatcagca cagtgcctaa agctattcct gtgagtcctt cagctgtgga 5340
agaggatgaa gatgaagatg gtcatactgt ggtggccaca gcccgaggca tatttaacag 5400
caatgggggc gtgctgagtt ccatagaaac tggtgttagt ataattatcc ctcaaggagc 5460
cattcccgaa ggagttgagc aggaaatcta tttcaaggtc tgccgggaca acagcatcct 5520
tccaccttta gataaagaga aaggtgaaac actgctgagt cctttggtga tgtgtggtcc 5580
ccatggcctc aagttcctga agcctgtgga gctgcgctta ccacactgtg atcctaaaac 5640
ctggcaaaac aagtgtcttc ccggagatcc aaattatctc gttggagcaa actgtgtttc 5700
tgtccttatt gaccactttt aactcttgaa atataggaac ttaaataatg tgaaactgga 5760
ttaaacttaa tctaaatgga accactctat caagtattat acctttttta gagttgatac 5820
tacagtttgt tagtatgagg catttgtttg aactgataaa gatgagtgag catgcccctg 5880
aaccatggtc ggaaaacatg ctacacactg catgtttgtg attgacggga ctgttggtat 5940
tggctagagg ttcaaagata ttttgctttg tgatttttgt aattttttta tcgtcactgc 6000
ttaacttcac atattgattt ccgttaaaat accagccagt aaatgggggt gcatttgagg 6060
tctgttcttt ccaaagtaca ctgtttcaaa ctttactatg gccctggcct agcatacgta 6120
cacattttat tttattatgc atgaagtaat atgcacacat tttttaaatg cacctggaat 6180
atataaccag tgttgtggat ttaacagaaa tgtacagcaa ggagatttac aactggggga 6240
gggtgaagtg aagacaatga cttactgtac atgaaaacac atttttctta gggaaggata 6300
caaaagcatg tgagactggt tccatggcct cttcagatct ctaacttcac catattacca 6360
cagacatact aaccagcaga aatgccttac cctcatgttc ttaattctta gctcattctc 6420
cttgtgttac taagttttta tggcttttgt gcattatcta gatactgtat catgacaaag 6480
actgagtacg ttgtgcattt ggtggtttca gaaatgtgtt atcacccaga agaaaatagt 6540
ggtgtgattt ggggatattt ttttcttttc ttttcttttc tttttttttt tttttgacaa 6600
ggggcagtgg tggttttctg ttctttctgg ctatgcattt gaaaattttg atgttttaag 6660
gatgcttgta cataatgcgt gcataccact tttgttcttg gtttgtaaat taacttttat 6720
aaactttacc ttttttatac ataaacaaga ccacgtttct aaaggctacc tttgtattct 6780
ctcctgtacc tcttgagcct tgaactttga cctctgcagc aataaagcag cgtttctatg 6840
acacatgcaa ggtcattttt tttaagaaaa aggatgcaca gagttgttac atttttaagt 6900
gctgcattta aaagatacag ttactcagaa ttctctagtt tgattaaatt cttgcaaagt 6960
atccctactg taatttgtga tacaatgctg tgccctaaag tgtatttttt tactaataga 7020
caatttatta tggcacatca gcacgatttc tgtttagata atacaccact acattctgtt 7080
aatcattagg tgtgactgaa tttcttttgc cgttattaaa aatctcaaat ttctaaatct 7140
ccaaaataaa actttttaaa ataaagtgct ggcttggtct gtttgcccac tgttttctag 7200
tttcatgcag ctttataatc ctgttttaaa atcctgcaca caaatcccta tcacccagcg 7260
tcacctacca cctcgtcgtc tggtgttgca tgcagaattt ctccccttgg ccagcatgta 7320
cagatgggtg ggcagtgctc atctgaaggg ctcagactga agtggggcag aaggacctgg 7380
agacagagtg ggagaaggca gcaggccgac ttccccctgt gggtaaacac acacccctgc 7440
gtggagaaac acccctgcat ggggacacac gtgcgtttgt gtgtgtgcgt gtaaccattt 7500
gtatatggtt ttattcccca gataaatagc acgggcattg tttaatgtca cccacatttg 7560
ggggaagaaa atgggtttag tgagcataaa tattccattg tggacatcct acttacttaa 7620
ctgccacccc tgttgacatt tggattattg ctatagtgtt tcagtaaaca cctttgtgga 7680
ctgaatccat ctatgtggat tttatttttt tcatctttgt taaggtataa tttacataga 7740
gtaagttact gtttttaaaa tgtatagttc aaattttgac aaacacatac tgtttattta 7800
ccacggttaa tacatacaac agtttcttta tcttctctaa tcatttgtac ccctttatac 7860
tcaacccttc ttccagcccc tggcaggatg atctcttctg tttctatagt tgcctttttg 7920
acagtgtcat ataaatggaa tcatacaata aaaaaaaaaa aaaaaaaaaa a          7971


<210> 38
<211> 1748
<212> PRT
<213> Homo sapiens

<400> 38
Met Ser Ala Arg Ala Ala Ala Ala Lys Ser Thr Ala Met Glu Glu Thr
 1               5                  10                  15      
Ala Ile Trp Glu Gln His Thr Val Thr Leu His Arg Ala Pro Gly Phe
            20                  25                  30          
Gly Phe Gly Ile Ala Ile Ser Gly Gly Arg Asp Asn Pro His Phe Gln
        35                  40                  45              
Ser Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu Lys Gly Gly Pro
    50                  55                  60                  
Ala Glu Gly Gln Leu Gln Glu Asn Asp Arg Val Ala Met Val Asn Gly
65                  70                  75                  80  
Val Ser Met Asp Asn Val Glu His Ala Phe Ala Val Gln Gln Leu Arg
                85                  90                  95      
Lys Ser Gly Lys Asn Ala Lys Ile Thr Ile Arg Arg Lys Lys Lys Val
            100                 105                 110         
Gln Ile Pro Val Ser Arg Pro Asp Pro Glu Pro Val Ser Asp Asn Glu
        115                 120                 125             
Glu Asp Ser Tyr Asp Glu Glu Ile His Asp Pro Arg Ser Gly Arg Ser
    130                 135                 140                 
Gly Val Val Asn Arg Arg Ser Glu Lys Ile Trp Pro Arg Asp Arg Ser
145                 150                 155                 160 
Ala Ser Arg Glu Arg Ser Leu Ser Pro Arg Ser Asp Arg Arg Ser Val
                165                 170                 175     
Ala Ser Ser Gln Pro Ala Lys Pro Thr Lys Val Thr Leu Val Lys Ser
            180                 185                 190         
Arg Lys Asn Glu Glu Tyr Gly Leu Arg Leu Ala Ser His Ile Phe Val
        195                 200                 205             
Lys Glu Ile Ser Gln Asp Ser Leu Ala Ala Arg Asp Gly Asn Ile Gln
    210                 215                 220                 
Glu Gly Asp Val Val Leu Lys Ile Asn Gly Thr Val Thr Glu Asn Met
225                 230                 235                 240 
Ser Leu Thr Asp Ala Lys Thr Leu Ile Glu Arg Ser Lys Gly Lys Leu
                245                 250                 255     
Lys Met Val Val Gln Arg Asp Glu Arg Ala Thr Leu Leu Asn Val Pro
            260                 265                 270         
Asp Leu Ser Asp Ser Ile His Ser Ala Asn Ala Ser Glu Arg Asp Asp
        275                 280                 285             
Ile Ser Glu Ile Gln Ser Leu Ala Ser Asp His Ser Gly Arg Ser His
    290                 295                 300                 
Asp Arg Pro Pro Arg Arg Ser Arg Ser Arg Ser Pro Asp Gln Arg Ser
305                 310                 315                 320 
Glu Pro Ser Asp His Ser Arg His Ser Pro Gln Gln Pro Ser Asn Gly
                325                 330                 335     
Ser Leu Arg Ser Arg Asp Glu Glu Arg Ile Ser Lys Pro Gly Ala Val
            340                 345                 350         
Ser Thr Pro Val Lys His Ala Asp Asp His Thr Pro Lys Thr Val Glu
        355                 360                 365             
Glu Val Thr Val Glu Arg Asn Glu Lys Gln Thr Pro Ser Leu Pro Glu
    370                 375                 380                 
Pro Lys Pro Val Tyr Ala Gln Val Gly Gln Pro Asp Val Asp Leu Pro
385                 390                 395                 400 
Val Ser Pro Ser Asp Gly Val Leu Pro Asn Ser Thr His Glu Asp Gly
                405                 410                 415     
Ile Leu Arg Pro Ser Met Lys Leu Val Lys Phe Arg Lys Gly Asp Ser
            420                 425                 430         
Val Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly Ile Phe Val Ala
        435                 440                 445             
Gly Val Leu Glu Asp Ser Pro Ala Ala Lys Glu Gly Leu Glu Glu Gly
    450                 455                 460                 
Asp Gln Ile Leu Arg Val Asn Asn Val Asp Phe Thr Asn Ile Ile Arg
465                 470                 475                 480 
Glu Glu Ala Val Leu Phe Leu Leu Asp Leu Pro Lys Gly Glu Glu Val
                485                 490                 495     
Thr Ile Leu Ala Gln Lys Lys Lys Asp Val Tyr Arg Arg Ile Val Glu
            500                 505                 510         
Ser Asp Val Gly Asp Ser Phe Tyr Ile Arg Thr His Phe Glu Tyr Glu
        515                 520                 525             
Lys Glu Ser Pro Tyr Gly Leu Ser Phe Asn Lys Gly Glu Val Phe Arg
    530                 535                 540                 
Val Val Asp Thr Leu Tyr Asn Gly Lys Leu Gly Ser Trp Leu Ala Ile
545                 550                 555                 560 
Arg Ile Gly Lys Asn His Lys Glu Val Glu Arg Gly Ile Ile Pro Asn
                565                 570                 575     
Lys Asn Arg Ala Glu Gln Leu Ala Ser Val Gln Tyr Thr Leu Pro Lys
            580                 585                 590         
Thr Ala Gly Gly Asp Arg Ala Asp Phe Trp Arg Phe Arg Gly Leu Arg
        595                 600                 605             
Ser Ser Lys Arg Asn Leu Arg Lys Ser Arg Glu Asp Leu Ser Ala Gln
    610                 615                 620                 
Pro Val Gln Thr Lys Phe Pro Ala Tyr Glu Arg Val Val Leu Arg Glu
625                 630                 635                 640 
Ala Gly Phe Leu Arg Pro Val Thr Ile Phe Gly Pro Ile Ala Asp Val
                645                 650                 655     
Ala Arg Glu Lys Leu Ala Arg Glu Glu Pro Asp Ile Tyr Gln Ile Ala
            660                 665                 670         
Lys Ser Glu Pro Arg Asp Ala Gly Thr Asp Gln Arg Ser Ser Gly Ile
        675                 680                 685             
Ile Arg Leu His Thr Ile Lys Gln Ile Ile Asp Gln Asp Lys His Ala
    690                 695                 700                 
Leu Leu Asp Val Thr Pro Asn Ala Val Asp Arg Leu Asn Tyr Ala Gln
705                 710                 715                 720 
Trp Tyr Pro Ile Val Val Phe Leu Asn Pro Asp Ser Lys Gln Gly Val
                725                 730                 735     
Lys Thr Met Arg Met Arg Leu Cys Pro Glu Ser Arg Lys Ser Ala Arg
            740                 745                 750         
Lys Leu Tyr Glu Arg Ser His Lys Leu Arg Lys Asn Asn His His Leu
        755                 760                 765             
Phe Thr Thr Thr Ile Asn Leu Asn Ser Met Asn Asp Gly Trp Tyr Gly
    770                 775                 780                 
Ala Leu Lys Glu Ala Ile Gln Gln Gln Gln Asn Gln Leu Val Trp Val
785                 790                 795                 800 
Ser Glu Gly Lys Ala Asp Gly Ala Thr Ser Asp Asp Leu Asp Leu His
                805                 810                 815     
Asp Asp Arg Leu Ser Tyr Leu Ser Ala Pro Gly Ser Glu Tyr Ser Met
            820                 825                 830         
Tyr Ser Thr Asp Ser Arg His Thr Ser Asp Tyr Glu Asp Thr Asp Thr
        835                 840                 845             
Glu Gly Gly Ala Tyr Thr Asp Gln Glu Leu Asp Glu Thr Leu Asn Asp
    850                 855                 860                 
Glu Val Gly Thr Pro Pro Glu Ser Ala Ile Thr Arg Ser Ser Glu Pro
865                 870                 875                 880 
Val Arg Glu Asp Ser Ser Gly Met His His Glu Asn Gln Thr Tyr Pro
                885                 890                 895     
Pro Tyr Ser Pro Gln Ala Gln Pro Gln Pro Ile His Arg Ile Asp Ser
            900                 905                 910         
Pro Gly Phe Lys Pro Ala Ser Gln Gln Lys Ala Glu Ala Ser Ser Pro
        915                 920                 925             
Val Pro Tyr Leu Ser Pro Glu Thr Asn Pro Ala Ser Ser Thr Ser Ala
    930                 935                 940                 
Val Asn His Asn Val Asn Leu Thr Asn Val Arg Leu Glu Glu Pro Thr
945                 950                 955                 960 
Pro Ala Pro Ser Thr Ser Tyr Ser Pro Gln Ala Asp Ser Leu Arg Thr
                965                 970                 975     
Pro Ser Thr Glu Ala Ala His Ile Met Leu Arg Asp Gln Glu Pro Ser
            980                 985                 990         
Leu Ser Ser His Val Asp Pro Thr Lys Val Tyr Arg Lys Asp Pro Tyr
        995                 1000                1005            
Pro Glu Glu Met Met Arg Gln Asn His Val Leu Lys Gln Pro Ala Val
    1010                1015                1020                
Ser His Pro Gly His Arg Pro Asp Lys Glu Pro Asn Leu Thr Tyr Glu
1025                1030                1035               1040 
Pro Gln Leu Pro Tyr Val Glu Lys Gln Ala Ser Arg Asp Leu Glu Gln
                1045                1050                1055    
Pro Thr Tyr Arg Tyr Glu Ser Ser Ser Tyr Thr Asp Gln Phe Ser Arg
            1060                1065                1070        
Asn Tyr Glu His Arg Leu Arg Tyr Glu Asp Arg Val Pro Met Tyr Glu
        1075                1080                1085            
Glu Gln Trp Ser Tyr Tyr Asp Asp Lys Gln Pro Tyr Pro Ser Arg Pro
    1090                1095                1100                
Pro Phe Asp Asn Gln His Ser Gln Asp Leu Asp Ser Arg Gln His Pro
1105                1110                1115               1120 
Glu Glu Ser Ser Glu Arg Gly Tyr Phe Pro Arg Phe Glu Glu Pro Ala
                1125                1130                1135    
Pro Leu Ser Tyr Asp Ser Arg Pro Arg Tyr Glu Gln Ala Pro Arg Ala
            1140                1145                1150        
Ser Ala Leu Arg His Glu Glu Gln Pro Ala Pro Gly Tyr Asp Thr His
        1155                1160                1165            
Gly Arg Leu Arg Pro Glu Ala Gln Pro His Pro Ser Ala Gly Pro Lys
    1170                1175                1180                
Pro Ala Glu Ser Lys Gln Tyr Phe Glu Gln Tyr Ser Arg Ser Tyr Glu
1185                1190                1195               1200 
Gln Val Pro Pro Gln Gly Phe Thr Ser Arg Ala Gly His Phe Glu Pro
                1205                1210                1215    
Leu His Gly Ala Ala Ala Val Pro Pro Leu Ile Pro Ser Ser Gln His
            1220                1225                1230        
Lys Pro Glu Ala Leu Pro Ser Asn Thr Lys Pro Leu Pro Pro Pro Pro
        1235                1240                1245            
Thr Gln Thr Glu Glu Glu Glu Asp Pro Ala Met Lys Pro Gln Ser Val
    1250                1255                1260                
Leu Thr Arg Val Lys Met Phe Glu Asn Lys Arg Ser Ala Ser Leu Glu
1265                1270                1275               1280 
Thr Lys Lys Asp Val Asn Asp Thr Gly Ser Phe Lys Pro Pro Glu Val
                1285                1290                1295    
Ala Ser Lys Pro Ser Gly Ala Pro Ile Ile Gly Pro Lys Pro Thr Ser
            1300                1305                1310        
Gln Asn Gln Phe Ser Glu His Asp Lys Thr Leu Tyr Arg Ile Pro Glu
        1315                1320                1325            
Pro Gln Lys Pro Gln Leu Lys Pro Pro Glu Asp Ile Val Arg Ser Asn
    1330                1335                1340                
His Tyr Asp Pro Glu Glu Asp Glu Glu Tyr Tyr Arg Lys Gln Leu Ser
1345                1350                1355               1360 
Tyr Phe Asp Arg Arg Ser Phe Glu Asn Lys Pro Pro Ala His Ile Ala
                1365                1370                1375    
Ala Ser His Leu Ser Glu Pro Ala Lys Pro Ala His Ser Gln Asn Gln
            1380                1385                1390        
Ser Asn Phe Ser Ser Tyr Ser Ser Lys Gly Lys Pro Pro Glu Ala Asp
        1395                1400                1405            
Gly Val Asp Arg Ser Phe Gly Glu Lys Arg Tyr Glu Pro Ile Gln Ala
    1410                1415                1420                
Thr Pro Pro Pro Pro Pro Leu Pro Ser Gln Tyr Ala Gln Pro Ser Gln
1425                1430                1435               1440 
Pro Val Thr Ser Ala Ser Leu His Ile His Ser Lys Gly Ala His Gly
                1445                1450                1455    
Glu Gly Asn Ser Val Ser Leu Asp Phe Gln Asn Ser Leu Val Ser Lys
            1460                1465                1470        
Pro Asp Pro Pro Pro Ser Gln Asn Lys Pro Ala Thr Phe Arg Pro Pro
        1475                1480                1485            
Asn Arg Glu Asp Thr Ala Gln Ala Ala Phe Tyr Pro Gln Lys Ser Phe
    1490                1495                1500                
Pro Asp Lys Ala Pro Val Asn Gly Thr Glu Gln Thr Gln Lys Thr Val
1505                1510                1515               1520 
Thr Pro Ala Tyr Asn Arg Phe Thr Pro Lys Pro Tyr Thr Ser Ser Ala
                1525                1530                1535    
Arg Pro Phe Glu Arg Lys Phe Glu Ser Pro Lys Phe Asn His Asn Leu
            1540                1545                1550        
Leu Pro Ser Glu Thr Ala His Lys Pro Asp Leu Ser Ser Lys Thr Pro
        1555                1560                1565            
Thr Ser Pro Lys Thr Leu Val Lys Ser His Ser Leu Ala Gln Pro Pro
    1570                1575                1580                
Glu Phe Asp Ser Gly Val Glu Thr Phe Ser Ile His Ala Glu Lys Pro
1585                1590                1595               1600 
Lys Tyr Gln Ile Asn Asn Ile Ser Thr Val Pro Lys Ala Ile Pro Val
                1605                1610                1615    
Ser Pro Ser Ala Val Glu Glu Asp Glu Asp Glu Asp Gly His Thr Val
            1620                1625                1630        
Val Ala Thr Ala Arg Gly Ile Phe Asn Ser Asn Gly Gly Val Leu Ser
        1635                1640                1645            
Ser Ile Glu Thr Gly Val Ser Ile Ile Ile Pro Gln Gly Ala Ile Pro
    1650                1655                1660                
Glu Gly Val Glu Gln Glu Ile Tyr Phe Lys Val Cys Arg Asp Asn Ser
1665                1670                1675               1680 
Ile Leu Pro Pro Leu Asp Lys Glu Lys Gly Glu Thr Leu Leu Ser Pro
                1685                1690                1695    
Leu Val Met Cys Gly Pro His Gly Leu Lys Phe Leu Lys Pro Val Glu
            1700                1705                1710        
Leu Arg Leu Pro His Cys Asp Pro Lys Thr Trp Gln Asn Lys Cys Leu
        1715                1720                1725            
Pro Gly Asp Pro Asn Tyr Leu Val Gly Ala Asn Cys Val Ser Val Leu
    1730                1735                1740                
Ile Asp His Phe
1745            

<210> 39
<211> 4725
<212> DNA
<213> Homo sapiens

<400> 39
gacgcggttc gccgcaggag cctcgaaggc gcggcgccgg cgagcccttc cccggcaggc 60
gcgtgggtgg tagcggccaa tttgacagtt tcccgggccg ggcggccagc gcggaggcgc 120
cacgctcggg tcgggggcgg gctgacgccg ccgccgccgc gggaggaggg acaaaggggt 180
gggtccccgc gggtcggcac cccggcggtt gggctgcggg tcagagcact gtccggtggt 240
gcccaggagg agtaggagca ggagcagaag cagaagcggg gtccggagct gcgcgcctac 300
gcgggacctg tgtccgaaat gccggtgcga ggagaccgcg ggtttccacc ccggcgggag 360
ctgtcaggtt ggctccgcgc cccaggcatg gaagagctga tatgggaaca gtacactgtg 420
accctacaaa aggattccaa aagaggattt ggaattgcag tgtccggagg cagagacaac 480
ccccactttg aaaatggaga aacgtcaatt gtcatttctg atgtgctccc gggtgggcct 540
gctgatgggc tgctccaaga aaatgacaga gtggtcatgg tcaatggcac ccccatggag 600
gatgtgcttc attcgtttgc agttcagcag ctcagaaaaa gtgggaaggt cgctgctatt 660
gtggtcaaga ggccccggaa ggtccaggtg gccgcacttc aggccagccc tcccctggat 720
caggatgacc gggcttttga ggtgatggac gagtttgatg gcagaagttt ccggagtggc 780
tacagcgaga ggagccggct gaacagccat ggggggcgca gccgcagctg ggaggacagc 840
ccggaaaggg ggcgtcccca tgagcgggcc cggagccggg agcgggacct cagccgggac 900
cggagccgtg gccggagcct ggagcggggc ctggaccaag accatgcgcg cacccgagac 960
cgcagccgtg gccggagcct ggagcggggc ctggaccacg actttgggcc atcccgggac 1020
cgggaccgtg accgcagccg cggccggagc attgaccagg actacgagcg agcctatcac 1080
cgggcctacg acccagacta cgagcgggcc tacagcccgg agtacaggcg cggggcccgc 1140
cacgatgccc gctctcgggg accccgaagc cgcagccgcg agcacccgca ctcacggagc 1200
cccagccccg agcctagggg gcggccgggg cccatcgggg tcctcctgat gaaaagcaga 1260
gcgaacgaag agtatggtct ccggcttggg agtcagatct tcgtaaagga aatgacccga 1320
acgggtctgg caactaaaga tggcaacctt cacgaaggag acataattct caagatcaat 1380
gggactgtaa ctgagaacat gtctttaacg gatgctcgaa aattgataga aaagtcaaga 1440
ggaaaactac agctagtggt gttgagagac agccagcaga ccctcatcaa catcccgtca 1500
ttaaatgaca gtgactcaga aatagaagat atttcagaaa tagagtcaaa ccgatcattt 1560
tctccagagg agagacgtca tcagtattct gattatgatt atcattcctc aagtgagaag 1620
ctgaaggaaa ggccaagttc cagagaggac acgccgagca gattgtccag gatgggtgcg 1680
acacccactc cctttaagtc cacaggggat attgcaggca cagttgtccc agagaccaac 1740
aaggaaccca gataccaaga ggacccccca gctcctcaac caaaagcagc cccgagaact 1800
tttcttcgtc ctagtcctga agatgaagca atatatggcc ctaataccaa aatggtaagg 1860
ttcaagaagg gagacagcgt gggcctccgg ttggctggtg gcaatgatgt cgggatattt 1920
gttgctggca ttcaagaagg gacctcggcg gagcaggagg gccttcaaga aggagaccag 1980
attctgaagg tgaacacaca ggatttcaga ggattagtgc gggaggatgc cgttctctac 2040
ctgttagaaa tccctaaagg tgaaatggtg accattttag ctcagagccg agccgatgtg 2100
tatagagaca tcctggcttg tggcagaggg gattcgtttt ttataagaag ccactttgaa 2160
tgtgagaagg aaactccaca gagcctggcc ttcaccagag gggaggtctt ccgagtggta 2220
gacacactgt atgacggcaa gctgggcaac tggctggctg tgaggattgg gaacgagttg 2280
gagaaaggct taatccccaa caagagcaga gctgaacaaa tggccagtgt tcaaaatgcc 2340
cagagagaca acgctgggga ccgggcagat ttctggagaa tgcgtggcca gaggtctggg 2400
gtgaagaaga acctgaggaa aagtcgggaa gacctcacag ctgttgtgtc tgtcagcacc 2460
aagttcccag cttatgagag ggttttgctg cgagaagctg gtttcaagag acctgtggtc 2520
ttattcggcc ccatagctga tatagcaatg gaaaaattgg ctaatgagtt acctgactgg 2580
tttcaaactg ctaaaacgga accaaaagat gcaggatctg agaaatccac tggagtggtc 2640
cggttaaata ccgtgaggca aattattgaa caggataagc atgcactact ggatgtgact 2700
ccgaaagctg tggacctgtt gaattacacc cagtggttcc caattgtgat ttttttcaac 2760
ccagactcca gacaaggtgt caaaaccatg agacaaaggt taaatccaac gtccaacaaa 2820
agttctcgaa agttatttga tcaagccaac aagcttaaaa aaacgtgtgc acaccttttt 2880
acagctacaa tcaacctaaa ttcagccaat gatagctggt ttggcagctt aaaggacact 2940
attcagcatc agcaaggaga agcggtttgg gtctctgaag gaaagatgga agggatggat 3000
gatgaccccg aagaccgcat gtcctactta accgccatgg gcgcggacta tctgagttgc 3060
gacagccgcc tcatcagtga ctttgaagac acggacggtg aaggaggcgc ctacactgac 3120
aatgagctgg atgagccagc cgaggagccg ctggtgtcgt ccatcacccg ctcctcggag 3180
ccggtgcagc acgaggagag cataaggaaa cccagcccag agccacgagc tcagatgagg 3240
agggctgcta gcagcgatca acttagggac aatagcccgc ccccagcatt caagccagag 3300
ccgcccaagg ccaaaaccca gaacaaagaa gaatcctatg acttctccaa atcctatgaa 3360
tataagtcaa acccctctgc cgttgctggt aatgaaactc ctggggcatc taccaaaggt 3420
tatcctcctc ctgttgcagc aaaacctacc tttgggcggt ctatactgaa gccctccact 3480
cccatccctc ctcaagaggg tgaggaggtg ggagagagca gtgaggagca agataatgct 3540
cccaaatcag tcctgggcaa agtcaaaata tttgagaaga tggatcacaa ggccaggtta 3600
cagagaatgc aggagctcca ggaagcacag aatgcaagga tcgaaattgc ccagaagcat 3660
cctgatatct atgcagttcc aatcaaaacg cacaagccag accctggcac gccccagcac 3720
acgagttcca gaccccctga gccacagaaa gctccttcca gaccttatca ggataccaga 3780
ggaagttatg gcagtgatgc cgaggaggag gagtaccgcc agcagctgtc agaacactcc 3840
aagcgcggtt actatggcca gtctgcccga taccgggaca cagaattata gatgtctgag 3900
cacggactct cccaggcctg cctgcatggc atcagactag ccactcctgc caggccgccg 3960
ggatggttct tctccagtta gaatgcacca tggagacgtg gtgggactcc agctcgtgtg 4020
tcctcatgga gaacccaggg gacagctggt gcaaattcag aactgagggc tctgtttgtg 4080
ggactgggtt agaggagtct gtggcttttt gttcagaatt aagcagaaca ctgcagtcag 4140
atcctgttac ttgcttcagt ggaccgaaat ctgtattctg tttgcgtact tgtaatatgt 4200
atattaagaa gcaataacta tttttcctca ttaatagctg ccttcaagga ctgtttcagt 4260
gtgagtcaga atgtgaaaaa ggaataaaaa atactgttgg gctcaaacta aattcaaaga 4320
agtactttat tgcaactctt ttaagtgcct tggatgagaa gtgtcttaaa ttttcttcct 4380
ttgaagcttt aggcagagcc ataatggact aaaacatttt gactaagttt ttataccagc 4440
ttaatagctg tagttttccc tgcactgtgt catcttttca aggcatttgt ctttgtaata 4500
ttttccataa atttggactg tctatatcat aactatactt gatagtttgg ctataagtgc 4560
tcaatagctt gaagcccaag aagttggtat cgaaatttgt tgtttgttta aacccaagtg 4620
ctgcacaaaa gcagatactt gaggaaaaca ctatttccaa aagcacatgt attgacaaca 4680
gttttataat ttaataaaaa ggaatacatt gcaatccgta atttt                 4725

<210> 40
<211> 1190
<212> PRT
<213> Homo sapiens

<400> 40
Met Pro Val Arg Gly Asp Arg Gly Phe Pro Pro Arg Arg Glu Leu Ser
 1               5                  10                  15      
Gly Trp Leu Arg Ala Pro Gly Met Glu Glu Leu Ile Trp Glu Gln Tyr
            20                  25                  30          
Thr Val Thr Leu Gln Lys Asp Ser Lys Arg Gly Phe Gly Ile Ala Val
        35                  40                  45              
Ser Gly Gly Arg Asp Asn Pro His Phe Glu Asn Gly Glu Thr Ser Ile
    50                  55                  60                  
Val Ile Ser Asp Val Leu Pro Gly Gly Pro Ala Asp Gly Leu Leu Gln
65                  70                  75                  80  
Glu Asn Asp Arg Val Val Met Val Asn Gly Thr Pro Met Glu Asp Val
                85                  90                  95      
Leu His Ser Phe Ala Val Gln Gln Leu Arg Lys Ser Gly Lys Val Ala
            100                 105                 110         
Ala Ile Val Val Lys Arg Pro Arg Lys Val Gln Val Ala Ala Leu Gln
        115                 120                 125             
Ala Ser Pro Pro Leu Asp Gln Asp Asp Arg Ala Phe Glu Val Met Asp
    130                 135                 140                 
Glu Phe Asp Gly Arg Ser Phe Arg Ser Gly Tyr Ser Glu Arg Ser Arg
145                 150                 155                 160 
Leu Asn Ser His Gly Gly Arg Ser Arg Ser Trp Glu Asp Ser Pro Glu
                165                 170                 175     
Arg Gly Arg Pro His Glu Arg Ala Arg Ser Arg Glu Arg Asp Leu Ser
            180                 185                 190         
Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly Leu Asp Gln Asp
        195                 200                 205             
His Ala Arg Thr Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly
    210                 215                 220                 
Leu Asp His Asp Phe Gly Pro Ser Arg Asp Arg Asp Arg Asp Arg Ser
225                 230                 235                 240 
Arg Gly Arg Ser Ile Asp Gln Asp Tyr Glu Arg Ala Tyr His Arg Ala
                245                 250                 255     
Tyr Asp Pro Asp Tyr Glu Arg Ala Tyr Ser Pro Glu Tyr Arg Arg Gly
            260                 265                 270         
Ala Arg His Asp Ala Arg Ser Arg Gly Pro Arg Ser Arg Ser Arg Glu
        275                 280                 285             
His Pro His Ser Arg Ser Pro Ser Pro Glu Pro Arg Gly Arg Pro Gly
    290                 295                 300                 
Pro Ile Gly Val Leu Leu Met Lys Ser Arg Ala Asn Glu Glu Tyr Gly
305                 310                 315                 320 
Leu Arg Leu Gly Ser Gln Ile Phe Val Lys Glu Met Thr Arg Thr Gly
                325                 330                 335     
Leu Ala Thr Lys Asp Gly Asn Leu His Glu Gly Asp Ile Ile Leu Lys
            340                 345                 350         
Ile Asn Gly Thr Val Thr Glu Asn Met Ser Leu Thr Asp Ala Arg Lys
        355                 360                 365             
Leu Ile Glu Lys Ser Arg Gly Lys Leu Gln Leu Val Val Leu Arg Asp
    370                 375                 380                 
Ser Gln Gln Thr Leu Ile Asn Ile Pro Ser Leu Asn Asp Ser Asp Ser
385                 390                 395                 400 
Glu Ile Glu Asp Ile Ser Glu Ile Glu Ser Asn Arg Ser Phe Ser Pro
                405                 410                 415     
Glu Glu Arg Arg His Gln Tyr Ser Asp Tyr Asp Tyr His Ser Ser Ser
            420                 425                 430         
Glu Lys Leu Lys Glu Arg Pro Ser Ser Arg Glu Asp Thr Pro Ser Arg
        435                 440                 445             
Leu Ser Arg Met Gly Ala Thr Pro Thr Pro Phe Lys Ser Thr Gly Asp
    450                 455                 460                 
Ile Ala Gly Thr Val Val Pro Glu Thr Asn Lys Glu Pro Arg Tyr Gln
465                 470                 475                 480 
Glu Asp Pro Pro Ala Pro Gln Pro Lys Ala Ala Pro Arg Thr Phe Leu
                485                 490                 495     
Arg Pro Ser Pro Glu Asp Glu Ala Ile Tyr Gly Pro Asn Thr Lys Met
            500                 505                 510         
Val Arg Phe Lys Lys Gly Asp Ser Val Gly Leu Arg Leu Ala Gly Gly
        515                 520                 525             
Asn Asp Val Gly Ile Phe Val Ala Gly Ile Gln Glu Gly Thr Ser Ala
    530                 535                 540                 
Glu Gln Glu Gly Leu Gln Glu Gly Asp Gln Ile Leu Lys Val Asn Thr
545                 550                 555                 560 
Gln Asp Phe Arg Gly Leu Val Arg Glu Asp Ala Val Leu Tyr Leu Leu
                565                 570                 575     
Glu Ile Pro Lys Gly Glu Met Val Thr Ile Leu Ala Gln Ser Arg Ala
            580                 585                 590         
Asp Val Tyr Arg Asp Ile Leu Ala Cys Gly Arg Gly Asp Ser Phe Phe
        595                 600                 605             
Ile Arg Ser His Phe Glu Cys Glu Lys Glu Thr Pro Gln Ser Leu Ala
    610                 615                 620                 
Phe Thr Arg Gly Glu Val Phe Arg Val Val Asp Thr Leu Tyr Asp Gly
625                 630                 635                 640 
Lys Leu Gly Asn Trp Leu Ala Val Arg Ile Gly Asn Glu Leu Glu Lys
                645                 650                 655     
Gly Leu Ile Pro Asn Lys Ser Arg Ala Glu Gln Met Ala Ser Val Gln
            660                 665                 670         
Asn Ala Gln Arg Asp Asn Ala Gly Asp Arg Ala Asp Phe Trp Arg Met
        675                 680                 685             
Arg Gly Gln Arg Ser Gly Val Lys Lys Asn Leu Arg Lys Ser Arg Glu
    690                 695                 700                 
Asp Leu Thr Ala Val Val Ser Val Ser Thr Lys Phe Pro Ala Tyr Glu
705                 710                 715                 720 
Arg Val Leu Leu Arg Glu Ala Gly Phe Lys Arg Pro Val Val Leu Phe
                725                 730                 735     
Gly Pro Ile Ala Asp Ile Ala Met Glu Lys Leu Ala Asn Glu Leu Pro
            740                 745                 750         
Asp Trp Phe Gln Thr Ala Lys Thr Glu Pro Lys Asp Ala Gly Ser Glu
        755                 760                 765             
Lys Ser Thr Gly Val Val Arg Leu Asn Thr Val Arg Gln Ile Ile Glu
    770                 775                 780                 
Gln Asp Lys His Ala Leu Leu Asp Val Thr Pro Lys Ala Val Asp Leu
785                 790                 795                 800 
Leu Asn Tyr Thr Gln Trp Phe Pro Ile Val Ile Phe Phe Asn Pro Asp
                805                 810                 815     
Ser Arg Gln Gly Val Lys Thr Met Arg Gln Arg Leu Asn Pro Thr Ser
            820                 825                 830         
Asn Lys Ser Ser Arg Lys Leu Phe Asp Gln Ala Asn Lys Leu Lys Lys
        835                 840                 845             
Thr Cys Ala His Leu Phe Thr Ala Thr Ile Asn Leu Asn Ser Ala Asn
    850                 855                 860                 
Asp Ser Trp Phe Gly Ser Leu Lys Asp Thr Ile Gln His Gln Gln Gly
865                 870                 875                 880 
Glu Ala Val Trp Val Ser Glu Gly Lys Met Glu Gly Met Asp Asp Asp
                885                 890                 895     
Pro Glu Asp Arg Met Ser Tyr Leu Thr Ala Met Gly Ala Asp Tyr Leu
            900                 905                 910         
Ser Cys Asp Ser Arg Leu Ile Ser Asp Phe Glu Asp Thr Asp Gly Glu
        915                 920                 925             
Gly Gly Ala Tyr Thr Asp Asn Glu Leu Asp Glu Pro Ala Glu Glu Pro
    930                 935                 940                 
Leu Val Ser Ser Ile Thr Arg Ser Ser Glu Pro Val Gln His Glu Glu
945                 950                 955                 960 
Ser Ile Arg Lys Pro Ser Pro Glu Pro Arg Ala Gln Met Arg Arg Ala
                965                 970                 975     
Ala Ser Ser Asp Gln Leu Arg Asp Asn Ser Pro Pro Pro Ala Phe Lys
            980                 985                 990         
Pro Glu Pro Pro Lys Ala Lys Thr Gln Asn Lys Glu Glu Ser Tyr Asp
        995                 1000                1005            
Phe Ser Lys Ser Tyr Glu Tyr Lys Ser Asn Pro Ser Ala Val Ala Gly
    1010                1015                1020                
Asn Glu Thr Pro Gly Ala Ser Thr Lys Gly Tyr Pro Pro Pro Val Ala
1025                1030                1035               1040 
Ala Lys Pro Thr Phe Gly Arg Ser Ile Leu Lys Pro Ser Thr Pro Ile
                1045                1050                1055    
Pro Pro Gln Glu Gly Glu Glu Val Gly Glu Ser Ser Glu Glu Gln Asp
            1060                1065                1070        
Asn Ala Pro Lys Ser Val Leu Gly Lys Val Lys Ile Phe Glu Lys Met
        1075                1080                1085            
Asp His Lys Ala Arg Leu Gln Arg Met Gln Glu Leu Gln Glu Ala Gln
    1090                1095                1100                
Asn Ala Arg Ile Glu Ile Ala Gln Lys His Pro Asp Ile Tyr Ala Val
1105                1110                1115               1120 
Pro Ile Lys Thr His Lys Pro Asp Pro Gly Thr Pro Gln His Thr Ser
                1125                1130                1135    
Ser Arg Pro Pro Glu Pro Gln Lys Ala Pro Ser Arg Pro Tyr Gln Asp
            1140                1145                1150        
Thr Arg Gly Ser Tyr Gly Ser Asp Ala Glu Glu Glu Glu Tyr Arg Gln
        1155                1160                1165            
Gln Leu Ser Glu His Ser Lys Arg Gly Tyr Tyr Gly Gln Ser Ala Arg
    1170                1175                1180                
Tyr Arg Asp Thr Glu Leu
1185                1190

<210> 41
<211> 6753
<212> DNA
<213> Homo sapiens

<400> 41
gcggccgccc gggctaagag cggccggctg gagccgctga gcccccgctg cggccgggag 60
ctgcatgggg gagcgccggc agcgcttggg aagatgcccc ggccggagct gcccctgccg 120
gagggctggg aggaggcgcg cgacttcgac ggcaaggtct actacataga ccacacgaac 180
cgcaccacca gctggatcga cccgcgggac aggtacacca aaccgctcac ctttgctgac 240
tgcattagtg atgagttgcc gctaggatgg gaagaggcat atgacccaca ggttggagat 300
tacttcatag accacaacac caaaaccact cagattgagg atcctcgagt acaatggcgg 360
cgggagcagg aacatatgct gaaggattac ctggtggtgg cccaggaggc tctgagtgca 420
caaaaggaga tctaccaggt gaagcagcag cgcctggagc ttgcacagca ggagtaccag 480
caactgcatg ccgtctggga gcataagctg ggctcccagg tcagcttggt ctctggttca 540
tcatccagct ccaagtatga ccctgagatc ctgaaagctg aaattgccac tgcaaaatcc 600
cgggtcaaca agctgaagag agagatggtt cacctccagc acgagctgca gttcaaagag 660
cgtggctttc agaccctgaa gaaaatcgat aagaaaatgt ctgatgctca gggcagctac 720
aaactggatg aagctcaggc tgtcttgaga gaaacaaaag ccatcaaaaa ggctattacc 780
tgtggggaaa aggaaaagca agatctcatt aagagccttg ccatgttgaa ggacggcttc 840
cgcactgaca gggggtctca ctcagacctg tggtccagca gcagctctct ggagagttcg 900
agtttcccgc taccgaaaca gtacctggat gtgagctccc agacagacat ctcgggaagc 960
ttcggcatca acagcaacaa tcagttggca gagaaggtca gattgcgcct tcgatatgaa 1020
gaggctaaga gaaggatcgc caacctgaag atccagctgg ccaagcttga cagtgaggcc 1080
tggcctgggg tgctggactc agagagggac cggctgatcc ttatcaacga gaaggaggag 1140
ctgctgaagg agatgcgctt catcagcccc cgcaagtgga cccaggggga ggtggagcag 1200
ctggagatgg cccggaagcg gctggaaaag gacctgcagg cagcccggga cacccagagc 1260
aaggcgctga cggagaggtt aaagttaaac agtaagagga accagcttgt gagagaactg 1320
gaggaagcca cccggcaggt ggcaactctg cactcccagc tgaaaagtct ctcaagcagc 1380
atgcagtccc tgtcctcagg cagcagcccc ggatccctca cgtccagccg gggctccctg 1440
gttgcatcca gcctggactc ctccacttca gccagcttca ctgacctcta ctatgacccc 1500
tttgagcagc tggactcaga gctgcagagc aaggtggagt tcctgctcct ggagggggcc 1560
accggcttcc ggccctcagg ctgcatcacc accatccacg aggatgaggt ggccaagacc 1620
cagaaggcag agggaggtgg ccgcctgcag gctctgcgtt ccctgtctgg caccccaaag 1680
tccatgacct ccctatcccc acgttcctct ctctcctccc cctccccacc ctgttcccct 1740
ctcatggctg accccctcct ggctggtgat gccttcctca actccttgga gtttgaagac 1800
ccggagctga gtgccactct ttgtgaactg agccttggta acagcgccca ggaaagatac 1860
cggctggagg aaccaggaac ggagggcaag cagctgggcc aagctgtgaa tacggcccag 1920
gggtgtggcc tgaaagtggc ctgtgtctca gccgccgtat cggacgagtc agtggctgga 1980
gacagtggtg tgtacgaggc ttccgtgcag agactgggtg cttcagaagc tgctgcattt 2040
gacagtgacg aatcggaagc agtgggtgcg acccgaattc agattgccct gaagtatgat 2100
gagaagaata agcaatttgc aatattaatc atccagctga gtaacctttc tgctctgttg 2160
cagcaacaag accagaaagt gaatatccgc gtggctgtcc ttccttgctc tgaaagcaca 2220
acctgcctgt tccggacccg gcctctggac gcctcagaca ctctagtgtt caatgaggtg 2280
ttctgggtat ccatgtccta tccagccctt caccagaaga ccttaagagt cgatgtctgt 2340
accaccgaca ggagccatct ggaagagtgc ctgggaggcg cccagatcag cctggcggag 2400
gtctgccggt ctggggagag gtcgactcgc tggtacaacc ttctcagcta caaatacttg 2460
aagaaacaga gcagggagct caagccagtg ggagtcatgg cccctgcctc agggcctgcc 2520
agcacggacg ctgtgtctgc tctgttggaa cagacagcag tggagctgga gaagaggcag 2580
gagggcagga gcagcacaca gacactggaa gacagctgga ggtatgagga gaccagtgag 2640
aatgaggcag tagccgagga agaggaggag gaggtggagg aggaggaggg agaagaggat 2700
gttttcaccg agaaagcctc acctgatatg gatgggtacc cagcattaaa ggtggacaaa 2760
gagaccaaca cggagacccc ggccccatcc cccacagtgg tgcgacctaa ggaccggaga 2820
gtgggcaccc cgtcccaggg gccatttctt cgagggagca ccatcatccg ctctaagacc 2880
ttctccccag gaccccagag ccagtacgtg tgccggctga atcggagtga tagtgacagc 2940
tccactctgt ccaaaaagcc accttttgtt cgaaactccc tggagcgacg cagcgtccgg 3000
atgaagcggc cgtccccacc cccacagcct tcctcggtca agtcgctgcg ctccgagcgt 3060
ctgatccgta cctcgctgga cctggagtta gacctgcagg cgacaagaac ctggcacagc 3120
caattgaccc aggagatctc ggtgctgaag gagctcaagg agcagctgga acaagccaag 3180
agccacgggg agaaggagct gccacagtgg ttgcgtgagg acgagcgttt ccgcctgctg 3240
ctgaggatgc tggagaagcg gcagatggac cgagcggagc acaagggtga gcttcagaca 3300
gacaagatga tgagggcagc tgccaaggat gtgcacaggc tccgaggcca gagctgtaag 3360
gaacccccag aagttcagtc tttcagggag aagatggcat ttttcacccg gcctcggatg 3420
aatatcccag ctctctctgc agatgacgtc taatcgccag aaaagtattt cctttgttcc 3480
actgaccagg ctgtgaacat tgactgtggc taaagttatt tatgtggtgt tatatgaagg 3540
tactgagtca caagtcctct agtgctcttg ttggtttgaa gatgaaccga ctttttagtt 3600
tgggtcctac tgttgttatt aaaaacagaa caaaaacaaa acacacacac acacaaaaac 3660
agaaacaaaa aaaaccagca ttaaaataat aagattgtat agtttgtata tttaggagtg 3720
tatttttggg aaagaaaatt taaatgaact aaagcagtat tgagttgctg ctcttcttaa 3780
aatcgtttag attttttttg gtttgtacag ctccaccttt tagaggtctt actgcaataa 3840
gaagtaatgc ctgggggacg gtaatcctaa taggacgtcc cgcacttgtc acagtacagc 3900
taatttttcc tagttaacat attttgtaca atattaaaaa aatgcacaga aaccattggg 3960
ggggattcag aggtgcatcc acggatcttc ttgagctgtg acgtgttttt atgtggctgc 4020
ccaacgtgga gcgggcagtg tgataggctg ggtgggctaa gcagcctagt ctatgtgggt 4080
gacaggccac gctggtctca gatgcccagt gaagccacta acatgagtga ggggagggct 4140
gtggggaact ccattcagtt ttatctccat caataaagtg gcctttcaaa aagaatcttc 4200
ctcttgctct ctttttcttt cctacccctc acttcatctg tttccctgat ttttgactct 4260
cccctttcca gtcatttctt tcccacccat ccgcagtcct ggaaacattt attttttctt 4320
ttgcccactg ttttcatttg ctcattaaat taaaatgact gctcggctca ttgggaatcc 4380
acatccccaa gttagactgg ggatatgctc tctgtactgt ctccttctat ggaattccac 4440
cccacccaga gagagatgac ttcacagttt gttcatatga gcatcatccc atgtcgtccc 4500
caacccaggg gctggtaggt gctacagctt gtgcttcatg ctgctcctgt ggcccctatt 4560
cctacccagc tcagagcttt gcagggtcta ctgcagacaa tcagaagtca gtttctaaca 4620
aatagcaaca gccacaaatc tcttcctcct tcctctctga cattaccctg tgcaactttt 4680
ctcaaagtct gttgcaccac tcagcaaagc aagttgcacc agctatatca gaatcacctg 4740
gggcagccta ttaaaaatgc agactgttga gaccatcctg gctaacacgg tgaaaccctg 4800
tctctactaa aaatacaaaa aattagccgg ccgtggtggc gggcagctac tcgggaggct 4860
gaggcaggag aatgacctga acctgggagg cagagcttgc agtgagctga gattgtgcca 4920
ctgcactcca gcctgggtga cagagcaaga ctccgtctca aaaaaaaaaa aaaaagaaaa 4980
atgcagactg gctggcgcgg tggctcatgc ttgtaatccc agcactttgg gaggctgagg 5040
cgggcagatc aactgagatc gggggttcga gaccagcctg atcaacatgg agaaacctgg 5100
tctctactaa aaatacataa ttagctgggc gtagtggcgc atacctgtaa tcccagctac 5160
ttgggtggcc aaggcttgaa cccaggaggc ggaggttgcg gtgagccgag atggcgccat 5220
tgactccagc ctgggcaaca agagcgtaac tccatctcaa aaaaataata ataataaaaa 5280
taaaatgcag actgtcaggt cctctctaga cccactgaac tatcccgccc accctgggac 5340
ggtccccagt gccagtgttt tacccatgtt ccctctgtaa gtcttatgca caccgcaatt 5400
tgagagcccc actggtataa agtgagtgaa acccaggcag agacaggcaa aatggtgagg 5460
cccgcatcct attggtgagt cacacaggga acgctgaaat tcatggcctt ctccaggcta 5520
ctgggaaccc atgggcggtg atggagggag tggtgccacc ttcacttgct gctgaggctc 5580
ttccccctct ccccagcata ctccttacct ggctgtctct cctcatgtat aaggaaccta 5640
tagtggtgta gaatctactc ttcttccccc tgtggcttcc aggcccccct gtatagctgc 5700
tatccagccc gatttctcac cactggccca gggcttcctc ctgccccgtg gcttcacgtc 5760
tctgaacaca tcaatctctg atgttctctc tccttccatt gaattccacc agacacattc 5820
agggtttact tcgtaatgtc ttcatatgag tatcaatcaa caccttcccc aactcaattg 5880
tactaggttg tagagcacaa ggatggtctc gtgctgctct gtggcacctg tgcctacact 5940
cctctgagct ttgaggaggc tgctctcttt gctgacccca tgatcttttc tgcccttctg 6000
ttaagggcat tggccacagc aacggggcaa atgccccaag ctggctgtaa gtgacccatc 6060
cctttggctc ccatgattag accaaggaga ggcatggggt ccagctgagc cattcagaac 6120
cattccttag cattttccac tcaaaggtta gagatgagat tttctcttcc caaggctacc 6180
tctggccatg gttccagctt catgggggca atgggattag gaaaatgagg tcaacctgca 6240
aaggaaagca gatgcaagag atggagacag aatgggggtg tcctggggat cttggagcct 6300
gaattcattg gcacaaaagg cagcagcatc ctcactgtat ctgcagtcca tttggactca 6360
ataaaaactt tgaaagtcac atgtgttatg gaattccttc tcagtgacac attcatctgt 6420
gctcagttgt cccagcaagg gtcagcccct catacccctg cagcatccgc tgctatgaag 6480
cagagctgta aacgccctcc ctgtgtatag gaaaagctac atggagcaaa tcctcctgcc 6540
tgaagaagtg catctcagca tcacttcagc tgtcggggca tttgtgggga gaaccagacc 6600
acctctgcgg aaggcagcag accctcttcc agccatggat ggagttgaat tctctataaa 6660
cggttcacca gcaaaccacc aatacattcc attgtttgcc tagagagaaa tttaaaaata 6720
aataaatgtt cacttataaa aaaaaaaaaa aaa                              6753


<210> 42
<211> 1119
<212> PRT
<213> Homo sapiens

<400> 42
Met Pro Arg Pro Glu Leu Pro Leu Pro Glu Gly Trp Glu Glu Ala Arg
 1               5                  10                  15      
Asp Phe Asp Gly Lys Val Tyr Tyr Ile Asp His Thr Asn Arg Thr Thr
            20                  25                  30          
Ser Trp Ile Asp Pro Arg Asp Arg Tyr Thr Lys Pro Leu Thr Phe Ala
        35                  40                  45              
Asp Cys Ile Ser Asp Glu Leu Pro Leu Gly Trp Glu Glu Ala Tyr Asp
    50                  55                  60                  
Pro Gln Val Gly Asp Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Gln
65                  70                  75                  80  
Ile Glu Asp Pro Arg Val Gln Trp Arg Arg Glu Gln Glu His Met Leu
                85                  90                  95      
Lys Asp Tyr Leu Val Val Ala Gln Glu Ala Leu Ser Ala Gln Lys Glu
            100                 105                 110         
Ile Tyr Gln Val Lys Gln Gln Arg Leu Glu Leu Ala Gln Gln Glu Tyr
        115                 120                 125             
Gln Gln Leu His Ala Val Trp Glu His Lys Leu Gly Ser Gln Val Ser
    130                 135                 140                 
Leu Val Ser Gly Ser Ser Ser Ser Ser Lys Tyr Asp Pro Glu Ile Leu
145                 150                 155                 160 
Lys Ala Glu Ile Ala Thr Ala Lys Ser Arg Val Asn Lys Leu Lys Arg
                165                 170                 175     
Glu Met Val His Leu Gln His Glu Leu Gln Phe Lys Glu Arg Gly Phe
            180                 185                 190         
Gln Thr Leu Lys Lys Ile Asp Lys Lys Met Ser Asp Ala Gln Gly Ser
        195                 200                 205             
Tyr Lys Leu Asp Glu Ala Gln Ala Val Leu Arg Glu Thr Lys Ala Ile
    210                 215                 220                 
Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu Ile Lys
225                 230                 235                 240 
Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly Ser His
                245                 250                 255     
Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser Phe Pro
            260                 265                 270         
Leu Pro Lys Gln Tyr Leu Asp Val Ser Ser Gln Thr Asp Ile Ser Gly
        275                 280                 285             
Ser Phe Gly Ile Asn Ser Asn Asn Gln Leu Ala Glu Lys Val Arg Leu
    290                 295                 300                 
Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu Lys Ile
305                 310                 315                 320 
Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu Asp Ser
                325                 330                 335     
Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu Leu Lys
            340                 345                 350         
Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu Val Glu
        355                 360                 365             
Gln Leu Glu Met Ala Arg Lys Arg Leu Glu Lys Asp Leu Gln Ala Ala
    370                 375                 380                 
Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu Asn Ser
385                 390                 395                 400 
Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg Gln Val
                405                 410                 415     
Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met Gln Ser
            420                 425                 430         
Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg Gly Ser
        435                 440                 445             
Leu Val Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe Thr Asp
    450                 455                 460                 
Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Gln Ser Lys
465                 470                 475                 480 
Val Glu Phe Leu Leu Leu Glu Gly Ala Thr Gly Phe Arg Pro Ser Gly
                485                 490                 495     
Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln Lys Ala
            500                 505                 510         
Glu Gly Gly Gly Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly Thr Pro
        515                 520                 525             
Lys Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser Pro Ser
    530                 535                 540                 
Pro Pro Cys Ser Pro Leu Met Ala Asp Pro Leu Leu Ala Gly Asp Ala
545                 550                 555                 560 
Phe Leu Asn Ser Leu Glu Phe Glu Asp Pro Glu Leu Ser Ala Thr Leu
                565                 570                 575     
Cys Glu Leu Ser Leu Gly Asn Ser Ala Gln Glu Arg Tyr Arg Leu Glu
            580                 585                 590         
Glu Pro Gly Thr Glu Gly Lys Gln Leu Gly Gln Ala Val Asn Thr Ala
        595                 600                 605             
Gln Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val Ser Asp
    610                 615                 620                 
Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Val Gln Arg
625                 630                 635                 640 
Leu Gly Ala Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser Glu Ala
                645                 650                 655     
Val Gly Ala Thr Arg Ile Gln Ile Ala Leu Lys Tyr Asp Glu Lys Asn
            660                 665                 670         
Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu Ser Asn Leu Ser Ala Leu
        675                 680                 685             
Leu Gln Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Val Leu Pro
    690                 695                 700                 
Cys Ser Glu Ser Thr Thr Cys Leu Phe Arg Thr Arg Pro Leu Asp Ala
705                 710                 715                 720 
Ser Asp Thr Leu Val Phe Asn Glu Val Phe Trp Val Ser Met Ser Tyr
                725                 730                 735     
Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr Thr Asp
            740                 745                 750         
Arg Ser His Leu Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser Leu Ala
        755                 760                 765             
Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn Leu Leu
    770                 775                 780                 
Ser Tyr Lys Tyr Leu Lys Lys Gln Ser Arg Glu Leu Lys Pro Val Gly
785                 790                 795                 800 
Val Met Ala Pro Ala Ser Gly Pro Ala Ser Thr Asp Ala Val Ser Ala
                805                 810                 815     
Leu Leu Glu Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu Gly Arg
            820                 825                 830         
Ser Ser Thr Gln Thr Leu Glu Asp Ser Trp Arg Tyr Glu Glu Thr Ser
        835                 840                 845             
Glu Asn Glu Ala Val Ala Glu Glu Glu Glu Glu Glu Val Glu Glu Glu
    850                 855                 860                 
Glu Gly Glu Glu Asp Val Phe Thr Glu Lys Ala Ser Pro Asp Met Asp
865                 870                 875                 880 
Gly Tyr Pro Ala Leu Lys Val Asp Lys Glu Thr Asn Thr Glu Thr Pro
                885                 890                 895     
Ala Pro Ser Pro Thr Val Val Arg Pro Lys Asp Arg Arg Val Gly Thr
            900                 905                 910         
Pro Ser Gln Gly Pro Phe Leu Arg Gly Ser Thr Ile Ile Arg Ser Lys
        915                 920                 925             
Thr Phe Ser Pro Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu Asn Arg
    930                 935                 940                 
Ser Asp Ser Asp Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe Val Arg
945                 950                 955                 960 
Asn Ser Leu Glu Arg Arg Ser Val Arg Met Lys Arg Pro Ser Pro Pro
                965                 970                 975     
Pro Gln Pro Ser Ser Val Lys Ser Leu Arg Ser Glu Arg Leu Ile Arg
            980                 985                 990         
Thr Ser Leu Asp Leu Glu Leu Asp Leu Gln Ala Thr Arg Thr Trp His
        995                 1000                1005            
Ser Gln Leu Thr Gln Glu Ile Ser Val Leu Lys Glu Leu Lys Glu Gln
    1010                1015                1020                
Leu Glu Gln Ala Lys Ser His Gly Glu Lys Glu Leu Pro Gln Trp Leu
1025                1030                1035               1040 
Arg Glu Asp Glu Arg Phe Arg Leu Leu Leu Arg Met Leu Glu Lys Arg
                1045                1050                1055    
Gln Met Asp Arg Ala Glu His Lys Gly Glu Leu Gln Thr Asp Lys Met
            1060                1065                1070        
Met Arg Ala Ala Ala Lys Asp Val His Arg Leu Arg Gly Gln Ser Cys
        1075                1080                1085            
Lys Glu Pro Pro Glu Val Gln Ser Phe Arg Glu Lys Met Ala Phe Phe
    1090                1095                1100                
Thr Arg Pro Arg Met Asn Ile Pro Ala Leu Ser Ala Asp Asp Val
1105                1110                1115                

<210> 43
<211> 5052
<212> DNA
<213> Homo sapiens

<400> 43
gacacactcc tctacaacac cagagactcc caaacacaag gccttatatt gactcatttc 60
agctcacatc ctggcgactc tcaagagaga aacctcagag tgactaaaat ctccataatg 120
agaagacatg tacattcagt atctattttg gcattttccc caatacatct ctgctcatct 180
gactcttatc ttggcatctg cttcctggtg gatctgaact gacccataag ccacgcttac 240
tagtgatttt ccagaagatg aatccggcct cggcgccccc tccgctcccg ccgcctgggc 300
agcaagtgat ccacgtcacg caggacctag acacagacct cgaagccctc ttcaactctg 360
tcatgaatcc gaagcctagc tcgtggcgga agaagatcct gccggagtct ttctttaagg 420
agcctgattc gggctcgcac tcgcgccagt ccagcaccga ctcgtcgggc ggccacccgg 480
ggcctcgact ggctgggggt gcccagcatg tccgctcgca ctcgtcgccc gcgtccctgc 540
agctgggcac cggcgcgggt gctgcgggta gccccgcgca gcagcacgcg cacctccgcc 600
agcagtccta cgacgtgacc gacgagctgc cactgccccc gggctgggag atgaccttca 660
cggccactgg ccagaggtac ttcctcaatc acatagaaaa aatcaccaca tggcaagacc 720
ctaggaaggc gatgaatcag cctctgaatc atatgaacct ccaccctgcc gtcagttcca 780
caccagtgcc tcagaggtcc atggcagtat cccagccaaa tctcgtgatg aatcaccaac 840
accagcagca gatggccccc agtaccctga gccagcagaa ccaccccact cagaacccac 900
ccgcagggct catgagtatg cccaatgcgc tgaccactca gcagcagcag cagcagaaac 960
tgcggcttca gagaatccag atggagagag aaaggattcg aatgcgccaa gaggagctca 1020
tgaggcagga agctgccctc tgtcgacagc tccccatgga agctgagact cttgccccag 1080
ttcaggctgc tgtcaaccca cccacgatga ccccagacat gagatccatc actaataata 1140
gctcagatcc tttcctcaat ggagggccat atcattcgag ggagcagagc actgacagtg 1200
gcctggggtt agggtgctac agtgtcccca caactccgga ggacttcctc agcaatgtgg 1260
atgagatgga tacaggagaa aacgcaggac aaacacccat gaacatcaat ccccaacaga 1320
cccgtttccc tgatttcctt gactgtcttc caggaacaaa cgttgactta ggaactttgg 1380
aatctgaaga cctgatcccc ctcttcaatg atgtagagtc tgctctgaac aaaagtgagc 1440
cctttctaac ctggctgtaa tcactaccat tgtaacttgg atgtagccat gaccttacat 1500
ttcctgggcc tcttggaaaa agtgatggag cagagcaagt ctgcaggtgc accacttccc 1560
gcctccatga ctcgtgctcc ctccttttta tgttgccagt ttaatcattg cctggttttg 1620
attgagagta acttaagtta aacataaata aatattctat tttcattttc tgcaagcctg 1680
cgttcttgtg acagattata cagaattgtg tctgcaggat tgattatgca gaatactttt 1740
ctctttcttc tctgctgccc catggctaag ctttatgggt gttaattgaa atttatacac 1800
caattgattt taaaccataa aaagctgacc acaggcagtt acttctgagg gcatcttggt 1860
ccaggaaatg tgcacaaaat tcgacctgat ttacagtttc aaaaactgta ttgatgacag 1920
tagtaccaaa tgctttaaaa actatttaac ttgagcttta aaaatcattg tatggatagt 1980
aaaattctac tgtatggaat acaatgtaat tttgaatcca tgctggctct gatggctctt 2040
attagtctgt atttataaag gcacacagtc ctattgtagc ttatctttcg ttattttact 2100
gcagagcatc tagacaactt agtccctcca gcgggaaagt agcagcagca gcattagtca 2160
caggtcttac actacagatc ttgtgaaaga gaccagtttg gtactaatta tgagcatttt 2220
attcaaacaa aagtttttga aatattacaa ctggggattt aaaaaattgc agcttagaat 2280
ctgatggttt ttttttttct tgatgttgtt tgtttgtttt tgagatcgag ttttgctctt 2340
gttgtccagg ctggaatgca atggcacaat ctcggctcac tgcaacctct gccttctggg 2400
ttcaagcgat tctcctgcct tagcctcccg agtagctggg attacaggca cctgccacca 2460
cgtccggcta attttttgta ttttgagtag agacggggtt tcaccataat ggtcaggctg 2520
ttctcaaact cctgatctca ggtgatccac ccatctcggc ctcccaaagt gctgggatta 2580
ctggcgtgag ccaccgcacc cggccttgat gtttatttta taaagcactg taattttgta 2640
gctgatgaca aaaggcagcc aaatgttttt gataaatcag tggcaactgt atttttgtct 2700
tttgaaataa ctctgaaaac atcaggacaa catagatttc aacctgatag cacaccacac 2760
acagtgagct gttgcttttt aaattctgaa gccttgtcag gtttgcttcc tagatttcaa 2820
gtgtttaaaa taattctatc tatgaaactg aaggatgaag cagatctctg actgacatgt 2880
aaaaaaaaat gccctttgag ggtgtatggt ggagataaat gtttctgaat tcagtaaaat 2940
tgattcctaa gtatattatc ctaatcctgt ttgctacagt tggtataaaa aggcatgaaa 3000
tatgtattca atacctctta tgtaaccaaa accattttta attagctttt aaggactgag 3060
agagcatcat gttcaactgg catgcagtct gcctgcattg ccaatgaagt cctcaactgt 3120
ttaatatttt gaactaatat tatttataat ctatgaattt aatctttttt gaaagacttt 3180
aataatttga gtctctgaga ggatactttc aatttccatg ggggacttat ttgttgggga 3240
tcttaaataa gattcctttt gatctaccgg aatatacatg tacagagtac attggatcat 3300
gttggaaaga aggcaagtga aaaggtcaga gatgaagtag caaagttatg gaatatcgtg 3360
gaaaggatac tagttgtgaa atggaaagag acaagttata gtaccccaaa agcaaaacaa 3420
gcaggagatg caagagatgc cccaaaagga caaagcaaca attttctgtt gccaccttta 3480
taccggaaga ctctgttgta gaagaaaaga aggctttggt gcaccttatg tgggaggagg 3540
aggggcaggg catgctgatg ctgagcgtac aggcagacaa gagcgtagcc tgctgttgcc 3600
tccatcacta tgaaatgact tattttacct gaaggaccca tggtttatgt tcctctaatt 3660
cctttcactc tccctaagcc ctctgagaga gatgaagata gatgatttta ttgctactaa 3720
attgaaggga gcactatttc tttttgtctt ttgttagcaa aaaattgcaa aaagaattgt 3780
acattcttgc taaaaataaa taaataaata aaaaattaaa aaaacaaggg acctaacaaa 3840
actcagcagt gttactgtat ttttaaaaaa tatttttata gactcatttt caggttatta 3900
aatgtaagag aaacagatac ccctcttttt taaagtaggt aaatcattga tgatttatat 3960
taccaatttt tagaagtaat tttctagtaa gcttgtggca tcagaaaata ctagaagatt 4020
tttttagtta aattagttag aacatttatg aatgaatata ataaatattt tttcagaata 4080
aaatatggac cctttgtgtt tactaataga taaagccaga tataattttt tgtttttaag 4140
gccacaaaat atggcctttg ttaaagaaca ctaaagttag aaatctaaag ttagagcaac 4200
tttttaatgg ctatttccta ttattgtaag tgttaaaacc cctgcagaat tcttgataag 4260
gtgctattta tactatattt cttattataa gataactgtc tttagtcttc ttagtactag 4320
tctttttagt actaaatcaa tcagtaaaca tcatcatttc accccaaaat tttgtcacag 4380
aaaaggcgta tcaaatgaaa aataatttca gagatctttc tttcaagata ttttttcctg 4440
ataaaataca ttgtcttgaa gtaaatacat tgtcaaaacc taattgcaat tctgttaaat 4500
ctaagtaatt tttagacagt gtttcaccgt attatttagg atgtgaaatg ccatttcttt 4560
cactgattac accatataca ggaaacaggt aaaacagtga aaactttatt gtgctggttg 4620
atgccaactt ggttgaaaag ctctctgcag aagaagtgat ctagactgac agaagtgttg 4680
ctaattacaa gttgtgttct catgacgtaa ttagaaagta acttctcaaa gtacaacttt 4740
tatgaaaaaa ataagctgtt aaaaaaagga aatcgtaggt taatttaatt gggaaaatgg 4800
gcaattgaca gagaccattt tcctaacaca tatatgtgct agtactttaa ctttttaaaa 4860
ttttacttct acgttttgta atataaaaat ttctatttta agtttagaat gttatacgta 4920
ccgaaagtat gcagccaaat cgatcagatc aaaccatttt acctggagtt tggtactggt 4980
ttttacttct ctgaatctgt ataagaaaaa taaagacaat tgaacttcca aagaaaaaaa 5040
aaaaaaaaaa aa                                                     5052


<210> 44
<211> 400
<212> PRT
<213> Homo sapiens

<400> 44
Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln
 1               5                  10                  15      
Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe
            20                  25                  30          
Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu
        35                  40                  45              
Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln
    50                  55                  60                  
Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly
65                  70                  75                  80  
Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu
                85                  90                  95      
Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His
            100                 105                 110         
Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro
        115                 120                 125             
Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn
    130                 135                 140                 
His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn
145                 150                 155                 160 
Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro
                165                 170                 175     
Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn
            180                 185                 190         
His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn
        195                 200                 205             
His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala
    210                 215                 220                 
Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile
225                 230                 235                 240 
Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg
                245                 250                 255     
Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu
            260                 265                 270         
Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met
        275                 280                 285             
Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro
    290                 295                 300                 
Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys
305                 310                 315                 320 
Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu
                325                 330                 335     
Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro
            340                 345                 350         
Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn
        355                 360                 365             
Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn
    370                 375                 380                 
Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu
385                 390                 395                 400 

<210> 45
<211> 5408
<212> DNA
<213> Homo sapiens

<400> 45
gccgccgcca gggaaaagaa agggaggaag gaaggaacaa gaaaaggaaa taaagagaaa 60
ggggaggcgg ggaaaggcaa cgagctgtcc ggcctccgtc aagggagttg gagggaaaaa 120
gttctcaggc gccgcaggtc cgagtgcctc gcagcccctc ccgaggcgca gccgccagac 180
cagtggagcc ggggcgcagg gcgggggcgg aggcgccggg gcgggggatg cggggccgcg 240
gcgcagcccc ccggccctga gagcgaggac agcgccgccc ggcccgcagc cgtcgccgct 300
tctccacctc ggcccgtgga gccggggcgt ccgggcgtag ccctcgctcg cctgggtcag 360
ggggtgcgcg tcgggggagg cagaagccat ggatcccggg cagcagccgc cgcctcaacc 420
ggccccccag ggccaagggc agccgccttc gcagcccccg caggggcagg gcccgccgtc 480
cggacccggg caaccggcac ccgcggcgac ccaggcggcg ccgcaggcac cccccgccgg 540
gcatcagatc gtgcacgtcc gcggggactc ggagaccgac ctggaggcgc tcttcaacgc 600
cgtcatgaac cccaagacgg ccaacgtgcc ccagaccgtg cccatgaggc tccggaagct 660
gcccgactcc ttcttcaagc cgccggagcc caaatcccac tcccgacagg ccagtactga 720
tgcaggcact gcaggagccc tgactccaca gcatgttcga gctcattcct ctccagcttc 780
tctgcagttg ggagctgttt ctcctgggac actgaccccc actggagtag tctctggccc 840
agcagctaca cccacagctc agcatcttcg acagtcttct tttgagatac ctgatgatgt 900
acctctgcca gcaggttggg agatggcaaa gacatcttct ggtcagagat acttcttaaa 960
tcacatcgat cagacaacaa catggcagga ccccaggaag gccatgctgt cccagatgaa 1020
cgtcacagcc cccaccagtc caccagtgca gcagaatatg atgaactcgg cttcaggtcc 1080
tcttcctgat ggatgggaac aagccatgac tcaggatgga gaaatttact atataaacca 1140
taagaacaag accacctctt ggctagaccc aaggcttgac cctcgttttg ccatgaacca 1200
gagaatcagt cagagtgctc cagtgaaaca gccaccaccc ctggctcccc agagcccaca 1260
gggaggcgtc atgggtggca gcaactccaa ccagcagcaa cagatgcgac tgcagcaact 1320
gcagatggag aaggagaggc tgcggctgaa acagcaagaa ctgcttcggc aggtgaggcc 1380
acaggcaatg cggaatatca atcccagcac agcaaattct ccaaaatgtc aggagttagc 1440
cctgcgtagc cagttaccaa cactggagca ggatggtggg actcaaaatc cagtgtcttc 1500
tcccgggatg tctcaggaat tgagaacaat gacgaccaat agctcagatc ctttccttaa 1560
cagtggcacc tatcactctc gagatgagag tacagacagt ggactaagca tgagcagcta 1620
cagtgtccct cgaaccccag atgacttcct gaacagtgtg gatgagatgg atacaggtga 1680
tactatcaac caaagcaccc tgccctcaca gcagaaccgt ttcccagact accttgaagc 1740
cattcctggg acaaatgtgg accttggaac actggaagga gatggaatga acatagaagg 1800
agaggagctg atgccaagtc tgcaggaagc tttgagttct gacatcctta atgacatgga 1860
gtctgttttg gctgccacca agctagataa agaaagcttt cttacatggt tatagagccc 1920
tcaggcagac tgaattctaa atctgtgaag gatctaagga gacacatgca ccggaaattt 1980
ccataagcca gttgcagttt tcaggctaat acagaaaaag atgaacaaac gtccagcaag 2040
atactttaat cctctatttt gctcttcctt gtccattgct gctgttaatg tattgctgac 2100
ctctttcaca gttggctcta aagaatcaaa agaaaaaaac tttttatttc ttttgctatt 2160
aaaactactg ttcattttgg gggctggggg aagtgagcct gtttggatga tggatgccat 2220
tccttttgcc cagttaaatg ttcaccaatc attttaacta aatactcaga cttagaagtc 2280
agatgcttca tgtcacagca tttagtttgt tcaacagttg tttcttcagc ttcctttgtc 2340
cagtggaaaa acatgattta ctggtctgac aagccaaaaa tgttatatct gatattaaat 2400
acttaatgct gatttgaaga gatagctgaa accaaggctg aagactgttt tactttcagt 2460
attttctttt cctcctagtg ctatcattag tcacataatg accttgattt tattttagga 2520
gcttataagg catgagacaa tttccatata aatatattaa ttattgccac atactctaat 2580
atagattttg gtggataatt ttgtgggtgt gcattttgtt ctgttttgtt gggttttttg 2640
ttttttttgt ttttggcagg gtcggtgggg gggttggttg gttggttggt tttgtcggaa 2700
cctaggcaaa tgaccatatt agtgaatctg ttaatagttg tagcttggga tggttattgt 2760
agttgttttg gtaaaatctt catttcctgg ttttttttac caccttattt aaatctcgat 2820
tatctgctct ctcttttata tacatacaca cacccaaaca taacatttat aatagtgtgg 2880
tagtggaatg tatccttttt taggtttccc tgctttccag ttaattttta aaatggtagc 2940
gctttgtatg catttagaat acatgactag tagtttatat ttcactggta gtttaaatct 3000
ggttggggca gtctgcagat gtttgaagta gtttagtgtt ctagaaagag ctattactgt 3060
ggatagtgcc taggggagtg ctccacgccc tctgggcata cggtagatat tatctgatga 3120
attggaaagg agcaaaccag aaatggcttt attttctccc ttggactaat ttttaagtct 3180
cgattggaat tcagtgagta ggttcataat gtgcatgaca gaaataagct ttatagtggt 3240
ttaccttcat ttagctttgg aagttttctt tgccttagtt ttggaagtaa attctagttt 3300
gtagttctca tttgtaatga acacattaac gactagatta aaatattgcc ttcaagattg 3360
ttcttactta caagacttgc tcctacttct atgctgaaaa ttgaccctgg atagaatact 3420
ataaggtttt gagttagctg gaaaagtgat cagattaata aatgtatatt ggtagttgaa 3480
tttagcaaag aaatagagat aatcatgatt atacctttat ttttacagga agagatgatg 3540
taactagagt atgtgtctac aggagtaata atggtttcca aagagtattt tttaaaggaa 3600
caaaacgagc atgaattaac tcttcaatat aagctatgaa gtaatagttg gttgtgaatt 3660
aaagtggcac cagctagcac ctctgtgttt taagggtctt tcaatgtttc tagaataagc 3720
ccttattttc aagggttcat aacaggcata aaatctcttc tcctggcaaa agctgctatg 3780
aaaagcctca gcttgggaag atagattttt ttccccccaa ttacaaaatc taagtatttt 3840
ggcccttcaa tttggaggag ggcaaaagtt ggaagtaaga agttttattt taagtacttt 3900
cagtgctcaa aaaaatgcaa tcactgtgtt gtatataata gttcataggt tgatcactca 3960
taataattga ctctaaggct tttattaaga aaacagcaga aagattaaat cttgaattaa 4020
gtctgggggg aaatggccac tgcagatgga gttttagagt agtaatgaaa ttctacctag 4080
aatgcaaaat tgggtatatg aattacatag catgttgttg ggattttttt taatgtgcag 4140
aagatcaaag ctacttggaa ggagtgccta taatttgcca gtagccacag attaagatta 4200
tatcttatat atcagcagat tagctttagc ttagggggag ggtgggaaag tttggggggg 4260
gggttgtgaa gatttagggg gaccttgata gagaacttta taaacttctt tctctttaat 4320
aaagacttgt cttacaccgt gctgccatta aaggcagctg ttctagagtt tcagtcacct 4380
aagtacaccc acaaaacaat atgaatatgg agatcttcct ttacccctca actttaattt 4440
gcccagttat acctcagtgt tgtagcagta ctgtgatacc tggcacagtg ctttgatctt 4500
acgatgccct ctgtactgac ctgaaggaga cctaagagtc ctttcccttt ttgagtttga 4560
atcatagcct tgatgtggtc tcttgtttta tgtccttgtt cctaatgtaa aagtgcttaa 4620
ctgcttcttg gttgtattgg gtagcattgg gataagattt taactgggta ttcttgaatt 4680
gcttttacaa taaaccaatt ttataatctt taaatttatc aactttttac atttgtgtta 4740
ttttcagtca gggcttctta gatctactta tggttgatgg agcacattga tttggagttt 4800
cagatcttcc aaagcactat ttgttgtaat aacttttcta aatgtagtgc ctttaaagga 4860
aaaatgaaca cagggaagtg actttgctac aaataatgtt gctgtgttaa gtattcatat 4920
taaatacatg ccttctatat ggaacatggc agaaagactg aaaaataaca gtaattaatt 4980
gtgtaattca gaattcatac caatcagtgt tgaaactcaa acattgcaaa agtgggtggc 5040
aatattcagt gcttaacact tttctagcgt tggtacatct gagaaatgag tgctcaggtg 5100
gattttatcc tcgcaagcat gttgttataa gaattgtggg tgtgcctatc ataacaattg 5160
ttttctgtat cttgaaaaag tattctccac attttaaatg ttttatatta gagaattctt 5220
taatgcacac ttgtcaaata tatatatata gtaccaatgt taccttttta ttttttgttt 5280
tagatgtaag agcatgctca tatgttaggt acttacataa attgttacat tattttttct 5340
tatgtaatac ctttttgttt gtttatgtgg ttcaaatata ttctttcctt aaactcttaa 5400
aaaaaaaa                                                          5408


<210> 46
<211> 508
<212> PRT
<213> Homo sapiens

<400> 46
Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln
 1               5                  10                  15      
Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly
            20                  25                  30          
Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro
        35                  40                  45              
Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp
    50                  55                  60                  
Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val
65                  70                  75                  80  
Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe
                85                  90                  95      
Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala
            100                 105                 110         
Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser
        115                 120                 125             
Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro
    130                 135                 140                 
Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu
145                 150                 155                 160 
Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly
                165                 170                 175     
Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His
            180                 185                 190         
Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser
        195                 200                 205             
Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met
    210                 215                 220                 
Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met
225                 230                 235                 240 
Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr
                245                 250                 255     
Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg
            260                 265                 270         
Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln
        275                 280                 285             
Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln
    290                 295                 300                 
Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu
305                 310                 315                 320 
Lys Gln Gln Glu Leu Leu Arg Gln Val Arg Pro Gln Ala Met Arg Asn
                325                 330                 335     
Ile Asn Pro Ser Thr Ala Asn Ser Pro Lys Cys Gln Glu Leu Ala Leu
            340                 345                 350         
Arg Ser Gln Leu Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro
        355                 360                 365             
Val Ser Ser Pro Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn
    370                 375                 380                 
Ser Ser Asp Pro Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu
385                 390                 395                 400 
Ser Thr Asp Ser Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr
                405                 410                 415     
Pro Asp Asp Phe Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr
            420                 425                 430         
Ile Asn Gln Ser Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr
        435                 440                 445             
Leu Glu Ala Ile Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly
    450                 455                 460                 
Asp Gly Met Asn Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu
465                 470                 475                 480 
Ala Leu Ser Ser Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala
                485                 490                 495     
Thr Lys Leu Asp Lys Glu Ser Phe Leu Thr Trp Leu
            500                 505             