                         SEQUENCE LISTING

<110>  Auckland Uniservices Limited
       Proft, Thomas
 
<120>  Peptides and Uses Thereof

<130>  826787

<150>  NZ709611
<151>  2015-07-01

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  340
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu 
        275                 280                 285             


Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys 
    290                 295                 300                 


Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr 
305                 310                 315                 320 


Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys 
                325                 330                 335     


Lys Lys Asn Ala 
            340 


<210>  2
<211>  1023
<212>  DNA
<213>  Streptococcus pyogenes

<400>  2
atgaaattac gtcacttact attaacggga gcagccctaa ctagttttgc tgctacaaca       60

gttcacgggg agactgttgt aaacggagcc aaactaacag ttacaaaaaa ccttgattta      120

gttaatagca atgcattaat tccaaataca gattttacat ttaaaatcga acctgatact      180

actgtcaacg aagacggaaa taagtttaaa ggtgtagctt tgaacacacc gatgactaaa      240

gtcacttaca ccaattcaga taaaggtgga tcaaatacga aaactgcaga atttgatttt      300

tcagaagtta cttttgaaaa accaggtgtt tattattaca aagtaactga ggagaagata      360

gataaagttc ctggtgtttc ttatgataca acatcttaca ctgttcaagt tcatgtcttg      420

tggaatgaag agcaacaaaa accagtagct acttatattg ttggttataa agaaggtagt      480

aaggtgccaa ttcagttcaa aaatagctta gattctacta cattaacggt gaagaaaaaa      540

gtttcaggta ccggtggaga tcgctctaaa gattttaatt ttggtctgac tttaaaagca      600

aatcagtatt ataaggcgtc agaaaaagtc atgattgaga agacaactaa aggtggtcaa      660

gctcctgttc aaacagaggc tagtatagat caactctatc attttacctt gaaagatggt      720

gaatcaatca aagtcacaaa tcttccagta ggtgtggatt atgttgtcac tgaagacgat      780

tacaaatcag aaaaatatac aaccaacgtg gaagttagtc ctcaagatgg agctgtaaaa      840

aatatcgcag gtaattcaac tgaacaagag acatctactg ataaagatat gaccattact      900

tttacaaata aaaaagactt tgaagtgcca acaggagtag caatgactgt ggcaccatat      960

attgctttag gaattgtagc agttggtgga gctctttact ttgttaaaaa gaaaaatgct     1020

taa                                                                   1023


<210>  3
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - oligonucleotide synthesised in laboratory

<400>  3
gcggatccga tatgatgtca cattgagag                                         29


<210>  4
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  4
gcggatccgt cgtggggcaa taaaaaattc                                        30


<210>  5
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  5
cccgctcgag ggagccaaac taacagttac                                        30


<210>  6
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  6
cccgctcgag gtttacaaca gtctcccc                                          28


<210>  7
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  7
gagagagact cgagggaaat aagtttaaag gtgtagc                                37


<210>  8
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  8
gagagagact cgagagtatc aggttcgatt ttaaatg                                37


<210>  9
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  9
gagagagact cgagggtgtt tattattaca aag                                    33


<210>  10
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  10
gagagagact cgagaaaatc aaattctgca g                                      31


<210>  11
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  11
gagagagact cgagggtgtt tcttatgata caac                                   34


<210>  12
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  12
gagagagact cgagctcctc agttactttg                                        30


<210>  13
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  13
gagagagact cgagtcagaa aaagtcatga ttgag                                  35


<210>  14
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  14
gagagagact cgagtgcttt taaagtcaga cc                                     32


<210>  15
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  15
gagagagact cgagcctgtt caaacagagg ctag                                   34


<210>  16
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  16
gagagagact cgagagttgt cttctcaatc atgac                                  35


<210>  17
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  17
gagagagact cgagaaaaat atcgcaggta attc                                   34


<210>  18
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  18
gagagagact cgagttgagg actaacttcc acg                                    33


<210>  19
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  19
tcacaagctg ttcatgctgc acatgcagaa attaatgaag caggtaga                    48


<210>  20
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  20

Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg 
1               5                   10                  15      


<210>  21
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  21

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Leu Glu Ser Gln 
            20                  25                  30          


Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Leu Asp 
        35                  40                  45              


Gly Ala Lys Leu Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn 
    50                  55                  60                  


Ala Leu Ile Pro Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr 
65                  70                  75                  80  


Thr Val Asn Glu Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr 
                85                  90                  95      


Pro Met Thr Lys Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn 
            100                 105                 110         


Thr Lys Thr Ala Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro 
        115                 120                 125             


Gly Val Tyr Tyr Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro 
    130                 135                 140                 


Gly Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu 
145                 150                 155                 160 


Trp Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr 
                165                 170                 175     


Lys Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser 
            180                 185                 190         


Thr Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg 
        195                 200                 205             


Ser Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr 
    210                 215                 220                 


Lys Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln 
225                 230                 235                 240 


Ala Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr 
                245                 250                 255     


Leu Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val 
            260                 265                 270         


Asp Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr 
        275                 280                 285             


Asn Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly 
    290                 295                 300                 


Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr 
305                 310                 315                 320 


Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr 
                325                 330                 335     


Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu 
            340                 345                 350         


Tyr Phe Val Lys Lys Lys Asn Ala Met Lys Leu Arg His Leu Leu Leu 
        355                 360 1               5               


Thr Gly Ala Ala Leu Thr Ser Phe Ala Ala Thr Thr Val His Gly Glu 
    10                  15                  20                  


Thr Val Val Asn Leu Glu Ser Gln Ala Val His Ala Ala His Ala Glu 
25                  30                  35                  40  


Ile Asn Glu Ala Gly Arg Leu Asp Gly Ala Lys Leu Thr Val Thr Lys 
                45                  50                  55      


Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro Asn Thr Asp Phe 
            60                  65                  70          


Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu Asp Gly Asn Lys 
        75                  80                  85              


Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys Val Thr Tyr Thr 
    90                  95                  100                 


Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala Glu Phe Asp Phe 
105                 110                 115                 120 


Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr Tyr Lys Val Thr 
                125                 130                 135     


Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr Asp Thr Thr Ser 
            140                 145                 150         


Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln Lys Pro 
        155                 160                 165             


Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val Pro Ile 
    170                 175                 180                 


Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys Lys Lys 
185                 190                 195                 200 


Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe Gly Leu 
                205                 210                 215     


Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val Met Ile 
            220                 225                 230         


Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu Ala Ser 
        235                 240                 245             


Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser Ile Lys 
    250                 255                 260                 


Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu Asp Asp 
265                 270                 275                 280 


Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro Gln Asp 
                285                 290                 295     


Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr Ser 
            300                 305                 310         


Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe Glu 
        315                 320                 325             


Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala Leu Gly 
    330                 335                 340                 


Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn Ala 
345                 350                 355                 360 


<210>  22
<211>  373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  22

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Leu Glu Lys Gln 
            20                  25                  30          


Ala Glu Asp Lys Val Lys Ala Ser Arg Glu Ala Lys Lys Gln Val Glu 
        35                  40                  45              


Lys Ala Leu Glu Gln Leu Glu Asp Lys Val Gln Leu Asp Gly Ala Lys 
    50                  55                  60                  


Leu Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile 
65                  70                  75                  80  


Pro Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn 
                85                  90                  95      


Glu Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr 
            100                 105                 110         


Lys Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr 
        115                 120                 125             


Ala Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr 
    130                 135                 140                 


Tyr Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser 
145                 150                 155                 160 


Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu 
                165                 170                 175     


Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly 
            180                 185                 190         


Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu 
        195                 200                 205             


Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp 
    210                 215                 220                 


Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser 
225                 230                 235                 240 


Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val 
                245                 250                 255     


Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp 
            260                 265                 270         


Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val 
        275                 280                 285             


Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu 
    290                 295                 300                 


Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr 
305                 310                 315                 320 


Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn 
                325                 330                 335     


Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro 
            340                 345                 350         


Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val 
        355                 360                 365             


Lys Lys Lys Asn Ala 
    370             


<210>  23
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  23

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Leu Glu Ser Gln 
    50                  55                  60                  


Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Leu Asp 
65                  70                  75                  80  


Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys Val 
                85                  90                  95      


Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala Glu 
            100                 105                 110         


Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr Tyr 
        115                 120                 125             


Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr Asp 
    130                 135                 140                 


Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln 
145                 150                 155                 160 


Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys 
                165                 170                 175     


Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val 
            180                 185                 190         


Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn 
        195                 200                 205             


Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys 
    210                 215                 220                 


Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr 
225                 230                 235                 240 


Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu 
                245                 250                 255     


Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr 
            260                 265                 270         


Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser 
        275                 280                 285             


Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln 
    290                 295                 300                 


Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys 
305                 310                 315                 320 


Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile 
                325                 330                 335     


Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys 
            340                 345                 350         


Lys Asn Ala 
        355 


<210>  24
<211>  352
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  24

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Leu Glu Ser Gln Ala Val His Ala Ala His Ala Glu 
            100                 105                 110         


Ile Asn Glu Ala Gly Arg Leu Asp Gly Val Tyr Tyr Tyr Lys Val Thr 
        115                 120                 125             


Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr Asp Thr Thr Ser 
    130                 135                 140                 


Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln Lys Pro 
145                 150                 155                 160 


Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val Pro Ile 
                165                 170                 175     


Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys Lys Lys 
            180                 185                 190         


Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe Gly Leu 
        195                 200                 205             


Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val Met Ile 
    210                 215                 220                 


Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu Ala Ser 
225                 230                 235                 240 


Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser Ile Lys 
                245                 250                 255     


Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu Asp Asp 
            260                 265                 270         


Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro Gln Asp 
        275                 280                 285             


Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr Ser 
    290                 295                 300                 


Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe Glu 
305                 310                 315                 320 


Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala Leu Gly 
                325                 330                 335     


Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn Ala 
            340                 345                 350         


<210>  25
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  25

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Ser Gln Ala Val His Ala Ala His 
        115                 120                 125             


Ala Glu Ile Asn Glu Ala Gly Arg Leu Asp Gly Val Ser Tyr Asp Thr 
    130                 135                 140                 


Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln 
145                 150                 155                 160 


Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val 
                165                 170                 175     


Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys 
            180                 185                 190         


Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe 
        195                 200                 205             


Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val 
    210                 215                 220                 


Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu 
225                 230                 235                 240 


Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser 
                245                 250                 255     


Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu 
            260                 265                 270         


Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro 
        275                 280                 285             


Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu 
    290                 295                 300                 


Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp 
305                 310                 315                 320 


Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala 
                325                 330                 335     


Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys 
            340                 345                 350         


Asn Ala 
        


<210>  26
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  26

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Leu Glu Ser Gln Ala Val His Ala 
        195                 200                 205             


Ala His Ala Glu Ile Asn Glu Ala Gly Arg Leu Asp Ser Glu Lys Val 
    210                 215                 220                 


Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu 
225                 230                 235                 240 


Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser 
                245                 250                 255     


Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu 
            260                 265                 270         


Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro 
        275                 280                 285             


Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu 
    290                 295                 300                 


Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp 
305                 310                 315                 320 


Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala 
                325                 330                 335     


Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys 
            340                 345                 350         


Asn Ala 
        


<210>  27
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  27

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Leu Glu Ser Gln Ala Val His Ala 
    210                 215                 220                 


Ala His Ala Glu Ile Asn Glu Ala Gly Arg Leu Asp Pro Val Gln Thr 
225                 230                 235                 240 


Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu 
                245                 250                 255     


Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr 
            260                 265                 270         


Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser 
        275                 280                 285             


Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln 
    290                 295                 300                 


Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys 
305                 310                 315                 320 


Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile 
                325                 330                 335     


Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys 
            340                 345                 350         


Lys Asn Ala 
        355 


<210>  28
<211>  369
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic - synthesised in laboratory

<400>  28

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Leu Glu Lys Gln Ala Glu Asp Lys Val Lys Ala Ser Arg 
        275                 280                 285             


Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Gln Leu Glu Asp Lys 
    290                 295                 300                 


Val Gln Leu Asp Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr 
305                 310                 315                 320 


Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe 
                325                 330                 335     


Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala Leu 
            340                 345                 350         


Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn 
        355                 360                 365             


Ala 
    


<210>  29
<211>  5451
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  gene
<222>  (45)..(2318)
<223>  Spy0125 (Cpa)

<220>
<221>  gene
<222>  (2473)..(2868)
<223>  Spy0127 (Sip)

<220>
<221>  gene
<222>  (2901)..(3923)
<223>  Spy0128 (pilin)

<220>
<221>  gene
<222>  (3933)..(4646)
<223>  Spy0129 (SrtC)

<220>
<221>  gene
<222>  (4668)..(5315)
<223>  Spy0130

<400>  29
tgacttcaat agaatgatat gatgtcacat tgagaggaga gaaaatgaaa aaaacaaggt       60

ttccaaataa gcttaatact cttaatactc aaagggtatt aagtaaaaac tcaaaacgat      120

ttactgtcac tttagtggga gtctttttaa tgatcttcgc tttggtaact tccatggttg      180

gtgctaagac tgtttttggt ttagtagaat cctcgacgcc aaacgcaata aatccagatt      240

caagttcgga atacagatgg tatggatatg aatcttatgt aagagggcat ccatattata      300

aacagtttag agtagcacac gatttaaggg ttaacttaga aggaagtaga agttatcaag      360

tttattgctt taatttaaag aaagcatttc ctctcggatc agatagtagt gttaaaaagt      420

ggtataaaaa acatgatgga atctctacaa aatttgaaga ttatgcgatg agccctagaa      480

ttacgggaga tgagctaaat cagaagttac gagctgttat gtataatgga catccacaaa      540

atgccaatgg tattatggaa ggcttggaac ccttgaatgc tatcagagtt acacaagagg      600

cggtatggta ctattctgat aatgctccta tttctaatcc agatgaaagt tttaaaaggg      660

agtcagaaag taacttggtt agtacttctc aattatcttt gatgcgtcaa gctttgaagc      720

aactgattga tccgaatttg gcaactaaaa tgccaaaaca agttccggat gattttcagc      780

taagtatttt tgagtctgag gacaagggag ataaatataa taaaggatac caaaatcttt      840

tgagtggtgg tttagttcct actaaaccac caactccagg agacccacca atgcctccaa      900

atcaacctca aacgacttca gtacttatta gaaagtatgc tataggtgat tactctaaat      960

tgcttgaagg tgcaacatta cagttgacag gggataacgt gaatagtttt caagcgagag     1020

tgtttagcag taatgatatt ggagaaagaa ttgaactatc agatggaact tatactttaa     1080

ctgaattgaa ttctccagct ggttatagta tcgcagagcc aatcactttt aaggttgaag     1140

ctggcaaagt gtatactatt attgatggaa aacagattga aaatcccaat aaagagatag     1200

tagagcctta ctcagtagaa gcatataatg attttgaaga atttagcgtt ttaactacac     1260

aaaactatgc aaaattttat tatgcaaaaa ataaaaatgg aagttcacag gttgtctatt     1320

gctttaatgc agatctaaaa tctccaccag actctgaaga tggtgggaaa acaatgactc     1380

cagactttac aacaggagaa gtaaaataca ctcatattgc aggtcgtgac ctctttaaat     1440

atactgtgaa accaagagat accgatcctg acactttctt aaaacatatc aaaaaagtaa     1500

ttgagaaggg ttacagggaa aaaggacaag ctattgagta tagtggtcta actgagacac     1560

aattgcgtgc ggctactcag ttagcaatat attatttcac tgatagtgct gaattagata     1620

aggataaact aaaagactat catggttttg gagacatgaa tgatagtact ttagcagttg     1680

ctaaaatcct tgtagaatac gctcaagata gtaatcctcc acagctaact gaccttgatt     1740

tctttattcc gaataacaat aaatatcaat ctcttattgg aactcagtgg catccagaag     1800

atttagttga tattattcgt atggaagata aaaaagaagt tatacctgta actcataatt     1860

taacattgag aaaaacggtg actggtttag ctggtgacag aactaaagat ttccattttg     1920

aaattgaatt aaaaaataat aagcaagaat tgctttctca aactgttaaa acagataaaa     1980

caaacctcga atttaaagat ggtaaagcaa ccattaattt aaaacatggg gaaagtttaa     2040

cacttcaagg tttaccagaa ggttattctt accttgtcaa agaaacagat tctgaaggct     2100

ataaggttaa agttaatagc caagaagtag caaatgctac agtttcaaaa acaggaataa     2160

caagtgatga gacacttgct tttgaaaata ataaagagcc tgttgttcct acaggagttg     2220

atcaaaagat caatggctat ctagctttga tagttatcgc tggtatcagt ttggggatct     2280

ggggaattca cacgataagg ataagaaaac atgactagag ctgatttcag aacttctaat     2340

tcatctggag aacttaacaa actatcattt tcagataaag aagcaataaa gcccttactc     2400

ataggacttg ttaaaaaaat agcccttatt cttattggcg gctatctact ttttcacttt     2460

gtttttggat ttatgattat caaaagaaac gatatggctc ctagtgtaaa agcaggagat     2520

gctattttat tttatcgctt atctcagact tataaagtag aagaagcagt tgtttatgag     2580

gactctaaaa catctataac gaaagtcggt cggattattg ctcaagcagg tgatgaagtg     2640

gacctgacag aacaaggtga attaaaaatt aatggccata ttcaaaatga aggactaact     2700

tttataaaat caagagaagc taattatccg tatcgaattg ctgataatag ttatttgata     2760

ctcaatgatt actatagcca agagagtgag aattacctac aagatgcaat tgctaaagat     2820

gctataaaag gcacgattaa tacacttatt cgattaagaa accattaagc taaaggctta     2880

tttaaaaaag gagagaaaca atgaaattac gtcacttact attaacggga gcagccctaa     2940

ctagttttgc tgctacaaca gttcacgggg agactgttgt aaacggagcc aaactaacag     3000

ttacaaaaaa ccttgattta gttaatagca atgcattaat tccaaataca gattttacat     3060

ttaaaatcga acctgatact actgtcaacg aagacggaaa taagtttaaa ggtgtagctt     3120

tgaacacacc gatgactaaa gtcacttaca ccaattcaga taaaggtgga tcaaatacga     3180

aaactgcaga atttgatttt tcagaagtta cttttgaaaa accaggtgtt tattattaca     3240

aagtaactga ggagaagata gataaagttc ctggtgtttc ttatgataca acatcttaca     3300

ctgttcaagt tcatgtcttg tggaatgaag agcaacaaaa accagtagct acttatattg     3360

ttggttataa agaaggtagt aaggtgccaa ttcagttcaa aaatagctta gattctacta     3420

cattaacggt gaagaaaaaa gtttcaggta ccggtggaga tcgctctaaa gattttaatt     3480

ttggtctgac tttaaaagca aatcagtatt ataaggcgtc agaaaaagtc atgattgaga     3540

agacaactaa aggtggtcaa gctcctgttc aaacagaggc tagtatagat caactctatc     3600

attttacctt gaaagatggt gaatcaatca aagtcacaaa tcttccagta ggtgtggatt     3660

atgttgtcac tgaagacgat tacaaatcag aaaaatatac aaccaacgtg gaagttagtc     3720

ctcaagatgg agctgtaaaa aatatcgcag gtaattcaac tgaacaagag acatctactg     3780

ataaagatat gaccattact tttacaaata aaaaagactt tgaagtgcca acaggagtag     3840

caatgactgt ggcaccatat attgctttag gaattgtagc agttggtgga gctctttact     3900

ttgttaaaaa gaaaaatgct taaattatta ttatgatagt aagactgatt aagctccttg     3960

acaagttgat aaacgtcatt gttctttgtt tcttctttct ttgtttattg attgcggcac     4020

ttggaatcta cgatgcttta acagtttatc aaggagctaa tgctactaac tatcaacaat     4080

ataagaaaaa gggtgttcag tttgacgatt tattagctat taattctgat gttatggcat     4140

ggctgactgt taaaggaacg catattgatt atccaattgt acagggagag aataatttag     4200

aatatatcaa caaatcagta gaaggagagt actccttatc aggaagtgtt tttctagatt     4260

atcgtaataa agtaactttt gaagataaat actcattaat ctatgcacat catatggctg     4320

gaaatgttat gtttggcgaa ttacctaact ttaggaaaaa atcatttttt aataaacaca     4380

aagaatttag tattgaaacc aaaacaaagc aaaaactgaa aatcaatatt tttgcatgta     4440

tccaaacaga tgcttttgac agtttactgt ttaatccaat tgatgttgat atttctagta     4500

aaaatgaatt tttaaaccat atcaagcaaa aatcggtaca gtatcgtgaa atattgacaa     4560

caaatgaaag tcgttttgtt gccttatcaa cctgtgagga tatgacaaca gatggtagga     4620

ttatcgttat tggacaaatt gaataattgt aagagaaagg aggtcatatg aaaaaatcta     4680

tattaagaat tttagctatt ggttatttac ttatgagttt ttgtttgtta gactccgtag     4740

aggcagagaa cctcactgca agcattaata ttgaagttat taatcaagtt gatgttgcta     4800

ccaacaaaca atcctctgac atagatgaaa cgtttatgtt tgtaattgaa gcgttagata     4860

aagaaagtcc tttacctaat tcggtaacta cttctgttaa gggaaatggg aaaacatcat     4920

ttgaacagtt gactttttca gaagttggac aatatcatta taaaattcat caactgttag     4980

gtaagaatag tcaatatcat tatgatgaaa cagtatatga agttgttatt tacgtattgt     5040

ataatgagca aagtggtgct ttagaaacta acctagtttc taacaaactt ggagaaaccg     5100

aaaaatcgga gcttattttt aaacaagaat atagtgaaaa aacaccggaa cctcatcaac     5160

cagatacaac tgagaaggaa aaacctcaga aaaaacgtaa tggtattttg ccatcaactg     5220

gtgaaatggt gagttacgta tctgctttag gaattgtctt agtggctacc attactttgt     5280

attctattta taaaaagcta aagacaagca aatagattca attttaagca gagtaattct     5340

ccttgaggat ttaggaaaga tatgtaagaa aaaccaaaaa ttcctttact taatgataaa     5400

ggaatttttt attgccccac gacagcaaat tgttcgtaag cgtccaataa c              5451


<210>  30
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg 
1               5                   10                  15      


Ile 
    


<210>  31
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Lys Gln Ala Glu Asp Lys Val Lys Ala Ser Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


Val Glu Lys Ala Leu Glu Gln Leu Glu Asp Lys Val Gln 
            20                  25                  


<210>  32
<211>  15
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  32

Phe Gln Asp Ala Tyr Asn Ala Ala Gly Gly His Asn Ala Val Phe 
1               5                   10                  15  


<210>  33
<211>  20
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  33

Met Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ile Gln Gly 
            20  


<210>  34
<211>  10
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  34

Gly Ala Pro Ile Asn Ser Ala Thr Ala Met 
1               5                   10  


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  36
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile Lys Val 
1               5                   10                  15      


<210>  37
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Ser Pro Ser Tyr Val Tyr His Gln Phe 
1               5                   


<210>  38
<211>  23
<212>  PRT
<213>  Influenza A virus

<400>  38

Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
1               5                   10                  15      


Asp Tyr Glu Glu Leu Lys His 
            20              


<210>  39
<211>  56
<212>  PRT
<213>  Influenza A

<400>  39

Leu Gly His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr 
1               5                   10                  15      


Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser 
            20                  25                  30          


Ser Thr Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys 
        35                  40                  45              


Asn Cys Thr Leu Ile Asp Ala Leu 
    50                  55      


<210>  40
<211>  17
<212>  PRT
<213>  Influenza virus A

<400>  40

Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
1               5                   10                  15      


Gln 
    


<210>  41
<211>  23
<212>  PRT
<213>  Influenza virus A

<400>  41

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp 
            20              


<210>  42
<211>  20
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  42

Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu Leu Asn 
1               5                   10                  15      


Asn Ala Leu Gln 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  43

Ser Glu Phe Ala Tyr Gly Ser Phe Val Arg Thr Val Ser Leu Pro Val 
1               5                   10                  15      


Gly Ala Asp Glu 
            20  


<210>  44
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile Lys Val 
1               5                   10                  15      


<210>  45
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Leu Glu Ser Gln Ala Val His Ala Ala His Ala Glu Ile 
        275                 280                 285             


Asn Glu Ala Gly Arg Val Glu Lys Asn Ile Ala Gly Asn Ser Thr Glu 
    290                 295                 300                 


Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys 
305                 310                 315                 320 


Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr 
                325                 330                 335     


Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys 
            340                 345                 350         


Lys Lys Asn Ala 
        355     


<210>  46
<211>  168
<212>  DNA
<213>  Influenza virus A

<400>  46
cttggtcatc acgctgttcc taatggaact ttggtaaaaa caattactaa tgatcaaatt       60

gaagttacta atgctacaga acttgtacaa tcatctagta caggaagaat ttgtgattca      120

ccacatagaa ttcttgatgg taaaaattgt actttgatcg atgctctt                   168


<210>  47
<211>  51
<212>  DNA
<213>  Influenza virus A

<400>  47
aaaagaggtc tttttggagc tattgcaggt tttatcgaag gaggttggca a                51


<210>  48
<211>  69
<212>  DNA
<213>  Influenza virus A

<400>  48
tcacttttaa ctgaagttga aacacctatt agaaatgaat ggggttgtag atgtaatgat       60

tcatctgat                                                               69


<210>  49
<211>  394
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  49

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Leu Gly His His Ala Val Pro Asn 
        115                 120                 125             


Gly Thr Leu Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn 
    130                 135                 140                 


Ala Thr Glu Leu Val Gln Ser Ser Ser Thr Gly Arg Ile Cys Asp Ser 
145                 150                 155                 160 


Pro His Arg Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu 
                165                 170                 175     


Leu Glu Gly Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His 
            180                 185                 190         


Val Leu Trp Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val 
        195                 200                 205             


Gly Tyr Lys Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu 
    210                 215                 220                 


Asp Ser Thr Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly 
225                 230                 235                 240 


Asp Arg Ser Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln 
                245                 250                 255     


Tyr Tyr Lys Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly 
            260                 265                 270         


Gly Gln Ala Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His 
        275                 280                 285             


Phe Thr Leu Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val 
    290                 295                 300                 


Gly Val Asp Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr 
305                 310                 315                 320 


Thr Thr Asn Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile 
                325                 330                 335     


Ala Gly Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr 
            340                 345                 350         


Ile Thr Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala 
        355                 360                 365             


Met Thr Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly 
    370                 375                 380                 


Ala Leu Tyr Phe Val Lys Lys Lys Asn Ala 
385                 390                 


<210>  50
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  50

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Lys Arg Gly Leu Phe Gly Ala Ile 
        115                 120                 125             


Ala Gly Phe Ile Glu Gly Gly Trp Gln Leu Glu Glu Phe Leu Glu Gly 
    130                 135                 140                 


Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp 
145                 150                 155                 160 


Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys 
                165                 170                 175     


Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr 
            180                 185                 190         


Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser 
        195                 200                 205             


Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys 
    210                 215                 220                 


Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala 
225                 230                 235                 240 


Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu 
                245                 250                 255     


Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp 
            260                 265                 270         


Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn 
        275                 280                 285             


Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn 
    290                 295                 300                 


Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe 
305                 310                 315                 320 


Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val 
                325                 330                 335     


Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr 
            340                 345                 350         


Phe Val Lys Lys Lys Asn Ala 
        355                 


<210>  51
<211>  374
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  51

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Lys Arg Gly Leu Phe Gly Ala Ile 
        115                 120                 125             


Ala Gly Phe Ile Glu Gly Gly Trp Gln Leu Glu Lys Arg Gly Leu Phe 
    130                 135                 140                 


Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Leu Glu Gly Val 
145                 150                 155                 160 


Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn 
                165                 170                 175     


Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu 
            180                 185                 190         


Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr 
        195                 200                 205             


Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys 
    210                 215                 220                 


Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala 
225                 230                 235                 240 


Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro 
                245                 250                 255     


Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys 
            260                 265                 270         


Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr 
        275                 280                 285             


Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val 
    290                 295                 300                 


Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser 
305                 310                 315                 320 


Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr 
                325                 330                 335     


Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala 
            340                 345                 350         


Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe 
        355                 360                 365             


Val Lys Lys Lys Asn Ala 
    370                 


<210>  52
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  52

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Asn Ser Gly Gly Ser Leu Glu Ser 
        115                 120                 125             


Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys Arg 
    130                 135                 140                 


Cys Asn Asp Ser Ser Asp Leu Glu Glu Phe Arg Arg Ile Leu Glu Gly 
145                 150                 155                 160 


Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp 
                165                 170                 175     


Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys 
            180                 185                 190         


Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr 
        195                 200                 205             


Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser 
    210                 215                 220                 


Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys 
225                 230                 235                 240 


Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala 
                245                 250                 255     


Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu 
            260                 265                 270         


Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp 
        275                 280                 285             


Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn 
    290                 295                 300                 


Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn 
305                 310                 315                 320 


Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe 
                325                 330                 335     


Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val 
            340                 345                 350         


Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr 
        355                 360                 365             


Phe Val Lys Lys Lys Asn Ala 
    370                 375 


<210>  53
<211>  393
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  53

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Ser His Leu Thr Glu Val Glu Thr 
        115                 120                 125             


Pro Ile Arg Asn Glu Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp Leu 
    130                 135                 140                 


Lys Glu Ser Val Gly Ser Leu Glu Ser Leu Leu Thr Glu Val Glu Thr 
145                 150                 155                 160 


Pro Ile Arg Asn Glu Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp Leu 
                165                 170                 175     


Glu Gly Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val 
            180                 185                 190         


Leu Trp Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly 
        195                 200                 205             


Tyr Lys Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp 
    210                 215                 220                 


Ser Thr Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp 
225                 230                 235                 240 


Arg Ser Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr 
                245                 250                 255     


Tyr Lys Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly 
            260                 265                 270         


Gln Ala Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe 
        275                 280                 285             


Thr Leu Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly 
    290                 295                 300                 


Val Asp Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr 
305                 310                 315                 320 


Thr Asn Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala 
                325                 330                 335     


Gly Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile 
            340                 345                 350         


Thr Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met 
        355                 360                 365             


Thr Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala 
    370                 375                 380                 


Leu Tyr Phe Val Lys Lys Lys Asn Ala 
385                 390             


<210>  54
<211>  60
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  54
atgacagaac aacaatggaa ttttgctgga attgaagctg cagcttcagc tattcaagga       60


<210>  55
<211>  60
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  55
tatcaaggtg ttcaacaaaa atgggatgct actgcaacag aacttaataa cgctttacaa       60


<210>  56
<211>  60
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  56
tctgaatttg catatggttc atttgttcgt acagtttctc ttccagtcgg agcagatgaa       60


<210>  57
<211>  358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  57

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Met Thr Glu Gln Gln Trp Asn Phe 
        115                 120                 125             


Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Leu Glu Gly Val 
    130                 135                 140                 


Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn 
145                 150                 155                 160 


Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu 
                165                 170                 175     


Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr 
            180                 185                 190         


Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys 
        195                 200                 205             


Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala 
    210                 215                 220                 


Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro 
225                 230                 235                 240 


Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys 
                245                 250                 255     


Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr 
            260                 265                 270         


Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val 
        275                 280                 285             


Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser 
    290                 295                 300                 


Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr 
305                 310                 315                 320 


Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala 
                325                 330                 335     


Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe 
            340                 345                 350         


Val Lys Lys Lys Asn Ala 
        355             


<210>  58
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  58

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Leu Asp Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr 
        275                 280                 285             


Ala Thr Glu Leu Asn Asn Ala Leu Gln Val Glu Lys Asn Ile Ala Gly 
    290                 295                 300                 


Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr 
305                 310                 315                 320 


Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr 
                325                 330                 335     


Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu 
            340                 345                 350         


Tyr Phe Val Lys Lys Lys Asn Ala 
        355                 360 


<210>  59
<211>  358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  59

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Ser Asn Thr Lys Thr Ala Glu Phe Asp Phe Asp Phe Thr Phe 
    50                  55                  60                  


Lys Ile Glu Pro Asp Thr Thr Val Asn Glu Asp Gly Asn Lys Phe Lys 
65                  70                  75                  80  


Gly Val Ala Leu Asn Thr Pro Met Thr Lys Val Thr Tyr Thr Asn Ser 
                85                  90                  95      


Asp Lys Gly Gly Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Ser Glu Phe Ala Tyr Gly Ser Phe 
        115                 120                 125             


Val Arg Thr Val Ser Leu Pro Val Gly Ala Asp Glu Leu Glu Gly Val 
    130                 135                 140                 


Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn 
145                 150                 155                 160 


Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu 
                165                 170                 175     


Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr 
            180                 185                 190         


Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys 
        195                 200                 205             


Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala 
    210                 215                 220                 


Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro 
225                 230                 235                 240 


Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys 
                245                 250                 255     


Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr 
            260                 265                 270         


Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val 
        275                 280                 285             


Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser 
    290                 295                 300                 


Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr 
305                 310                 315                 320 


Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala 
                325                 330                 335     


Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe 
            340                 345                 350         


Val Lys Lys Lys Asn Ala 
        355             


<210>  60
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  60

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Gly Ser Val Pro Ser Glu Phe Leu 
        115                 120                 125             


Glu Glu Phe Arg Ser Asp Pro Ser Arg Lys Glu Val Phe Leu Glu Leu 
    130                 135                 140                 


Leu Gln Val Leu Ser Lys Glu Val Gly Asn Ser Arg Asn Ser Gly Arg 
145                 150                 155                 160 


Ile Leu Glu Gly Val Ser Tyr Asp Thr Thr Ser Tyr Thr Val Gln Val 
                165                 170                 175     


His Val Leu Trp Asn Glu Glu Gln Gln Lys Pro Val Ala Thr Tyr Ile 
            180                 185                 190         


Val Gly Tyr Lys Glu Gly Ser Lys Val Pro Ile Gln Phe Lys Asn Ser 
        195                 200                 205             


Leu Asp Ser Thr Thr Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly 
    210                 215                 220                 


Gly Asp Arg Ser Lys Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn 
225                 230                 235                 240 


Gln Tyr Tyr Lys Ala Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys 
                245                 250                 255     


Gly Gly Gln Ala Pro Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr 
            260                 265                 270         


His Phe Thr Leu Lys Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro 
        275                 280                 285             


Val Gly Val Asp Tyr Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys 
    290                 295                 300                 


Tyr Thr Thr Asn Val Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn 
305                 310                 315                 320 


Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met 
                325                 330                 335     


Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val 
            340                 345                 350         


Ala Met Thr Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly 
        355                 360                 365             


Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn Ala 
    370                 375                 


<210>  61
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  61

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Ser Gln Ala Val His Ala Ala His 
        115                 120                 125             


Ala Glu Ile Asn Glu Ala Gly Arg Val Glu Lys Gln Ala Glu Asp Lys 
    130                 135                 140                 


Val Lys Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu 
145                 150                 155                 160 


Gln Leu Glu Asp Lys Val Gln Val Glu Gly Val Ser Tyr Asp Thr Thr 
                165                 170                 175     


Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln Lys 
            180                 185                 190         


Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val Pro 
        195                 200                 205             


Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys Lys 
    210                 215                 220                 


Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe Gly 
225                 230                 235                 240 


Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val Met 
                245                 250                 255     


Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu Ala 
            260                 265                 270         


Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser Ile 
        275                 280                 285             


Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu Asp 
    290                 295                 300                 


Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro Gln 
305                 310                 315                 320 


Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr 
                325                 330                 335     


Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe 
            340                 345                 350         


Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala Leu 
        355                 360                 365             


Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn 
    370                 375                 380                 


Ala 
385 


<210>  62
<211>  365
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  62

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Ile Asp Gly Val Ser Tyr Asp Thr Thr Ser 
        115                 120                 125             


Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln Lys Pro 
    130                 135                 140                 


Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val Pro Ile 
145                 150                 155                 160 


Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys Lys Lys 
                165                 170                 175     


Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe Gly Leu 
            180                 185                 190         


Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val Met Ile 
        195                 200                 205             


Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu Ala Ser 
    210                 215                 220                 


Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser Ile Lys 
225                 230                 235                 240 


Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu Asp Asp 
                245                 250                 255     


Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro Gln Leu 
            260                 265                 270         


Glu Lys Gln Ala Glu Asp Lys Val Lys Ala Ser Arg Glu Ala Lys Lys 
        275                 280                 285             


Gln Val Glu Lys Ala Leu Glu Gln Leu Glu Asp Lys Val Gln Leu Asp 
    290                 295                 300                 


Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu Thr Ser Thr Asp Lys 
305                 310                 315                 320 


Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Phe Glu Val Pro Thr 
                325                 330                 335     


Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala Leu Gly Ile Val Ala 
            340                 345                 350         


Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys Asn Ala 
        355                 360                 365 


<210>  63
<211>  358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  63

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Leu Glu Ser Gln Ala 
                165                 170                 175     


Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly Arg Val Glu Thr 
            180                 185                 190         


Leu Thr Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys 
        195                 200                 205             


Asp Phe Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala 
    210                 215                 220                 


Ser Glu Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro 
225                 230                 235                 240 


Val Gln Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys 
                245                 250                 255     


Asp Gly Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr 
            260                 265                 270         


Val Val Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val 
        275                 280                 285             


Glu Val Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser 
    290                 295                 300                 


Thr Glu Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr 
305                 310                 315                 320 


Asn Lys Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala 
                325                 330                 335     


Pro Tyr Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe 
            340                 345                 350         


Val Lys Lys Lys Asn Ala 
        355             


<210>  64
<211>  5079
<212>  DNA
<213>  Streptococcus pyogenes

<400>  64
tgtaatagct ctctcctaaa cttctagtct acaataaaat tttatctaag cttataaaat       60

aaagcaattt aagaaactaa tttaacaata agtttagaag ctaagaatat tgatatacca      120

atattttatc aaaaaaagga ttcgataagg tgttaaaatg ggaaaaaaat taaatgaatt      180

ctctattaga atagctattc agtgatatta taatatttgt attaattaga aagaaggacc      240

ccaaatgaca taatcaaaaa tcttatcgta cactgtgacc atatacacgg ttgcaggaaa      300

ctaatattag aagcagcagt gtagtttatg acagctaagt ctgttatgtg gctaagttta      360

atggaaacag gcgaatgatt gaccaaaaaa acgctaagct actttagttt agaaggaggg      420

agaggatata ttgcaaaaga gggataaaac caattatgga agcgctaaca acaaacgacg      480

acaaacgacg atcggattac tgaaagtatt tttgacgttt gtagctctga taggaatagt      540

agggttttct atcagagcgt tcggagctga agaacaatct actgaaacta aaaaaacgtc      600

agtcattatt agaaaatatg ctgaaggtga ctactctaaa cttctagagg gagcaacctt      660

aaagcttgct caaattgaag gaagtggttt tcaagaacag agttttgaaa gtagtacttc      720

aggacaaaaa ttgcagttgt cggatggtac atatatttta actgaaacta aatcacctca      780

aggatatgag attgccgaac ctattacttt taaagttaca gctgggaaag tttttataaa      840

aggtaaagac ggtcagtttg tagagaacca aaataaagag gtcgcagaac catactctgt      900

aacagcctat aatgattttg atgatagtgg ttttataaat cctaaaacct tcactccata      960

tggcaagttt tactatgcaa aaaatgctaa tggaactagt caagtcgttt actgtttcaa     1020

cgtagactta cattctccgc cagacagtct tgacaaggga gaaacgattg atccagactt     1080

taatgagggg aaggaaatca aatatactca catattgggt gctgacttgt ttagctatgc     1140

taataaccct agggcctcaa caaacgatga gttattatct caagtaaaaa aagttttaga     1200

aaagggttat cgtgatgatt cgacgactta tgcgaattta acatcggtag aatttagagc     1260

agctacccaa ttggctattt attattttac agatagtgta gacctcgata atttagcaga     1320

ttatcatggt tttggagctt tgacaacaga agctttaaat gcaacaaaag aaatagttgc     1380

ttatgctgaa gacagggcta atcttcctaa catttctaat ttagattttt atgttcctaa     1440

tagtaataag tatcagtctt taattggaac acaatatcat ccagagtctt tagtggatat     1500

tattcgaatg gaagataaac aggctcctat tattcctatt actcacaagt taactatttc     1560

taaaactgtt actggaacta ttgcagataa gaaaaaagaa tttaactttg aaatacattt     1620

aaaatcttct gatggacaag ctataagtgg aacatatccg acaaactctg gagaactcac     1680

agttacagat ggaaaagcta ccttcacatt aaaggatgga gaatcattga ttgttgaggg     1740

gctaccttca ggttactctt atgaaattac cgaaacgggt gcttcagatt atgaggtaag     1800

tgttaatgga aaaaatgcac cagatggaaa agcgacgaaa gcctcagtta aggaagacga     1860

aacgataact tttgaaaacc gtaaagatct tgtcccacca actggtttga caacagatgg     1920

ggctatctat ctttggttgt tattacttgt tctactcggg ttatgggttt ggctaattgg     1980

tcgtaaggga ctaaaaaatg actaattacc taaatcgctt aaatgagaat ccactattta     2040

aagctttcat acggttagta cttaagattt ctattattgg gtttctaggt tacattctat     2100

ttcagtatat ttttggtgtc atgattatta acactaatgt tatgagtcct gctttaagtg     2160

caggtgatgg aatcttatat tatcgattga ctgatcgcta tcatattaat gatgtggtgg     2220

tctatgaggt tgataacact ttgaaagttg gtcgaattgt cgctcaagct ggcgatgagg     2280

ttagttttac gcaagaagga ggactgttga ttaatgggca tccaccagaa aaagaggtcc     2340

cttacctgac gtatcctcac tcaagtggcc caaattttcc ctataaagtt cctacgggta     2400

cgtatttcat attgaatgat tatcgtgaag aacgtttgga cagtcgttat tatggggcgt     2460

tacccatcaa tcaaatcaaa gggaaaatct caactctatt aagagtgaga ggaatttaaa     2520

aaatttggag agagaaaaaa tgaaaaaaaa caaattatta cttgctactg caatcttagc     2580

aactgcttta ggaacagctt ctttaaatca aaacgtaaaa gctgagacag caggagtgat     2640

tgatggttca acattagtag ttaaaaaaac attcccatct tatactgatg ataaagtttt     2700

aatgccaaaa gctgattata cttttaaagt agaggcagat gataatgcta aaggtaaaac     2760

taaagatggg ttagatatta agccaggagt gattgatggt ttagaaaata caaagactat     2820

tcattacggt aattctgata aaacgactgc taaagagaaa tccgttaatt ttgactttgc     2880

taatgtaaaa ttccctggtg ttggtgttta tcgttatacg gtttctgaag taaatggtaa     2940

caaggcaggc atagcttatg attctcaaca atggacagtt gatgtttatg tggtaaatag     3000

agaagatgga ggttttgagg ctaagtatat tgtttctaca gaaggtggac aatctgataa     3060

aaaaccagtt ctgtttaaaa atttttttga tacaacttcg ttaaaggtta ctaaaaaagt     3120

aacaggtaat actggggaac accaacgttc gtttagtttc acattattat taacacctaa     3180

tgaatgtttt gaaaaaggtc aagttgtaaa tattttacaa ggaggagaga ctaaaaaagt     3240

agttattggt gaggaatata gttttacctt aaaagataaa gaaagtgtta ctctatcaca     3300

attacctgtt ggaattgaat ataaggtcac tgaagaagat gttacaaaag atggttacaa     3360

aacaagtgcc actttgaaag atggagatgt tactgatggt tataatttag gtgattctaa     3420

aacgacagac aaatctactg acgaaatcgt tgtcacaaat aagcgtgaca ctcaagttcc     3480

aactggtgtt gtagggaccc ttgctccatt tgcagttctt agcattgtgg ctattggtgg     3540

agttatctat attacaaaac gtaaaaaagc ttaagtgatt agtcaaagaa tgatgatgac     3600

aattgtacag gttatcaata aagccattga tactctcatt cttatctttt gtttagtcgt     3660

actattttta gctggttttg gtttgtggga ttcttatcat ctctatcaac aagcagacgc     3720

ttctaatttc aaaaaattta aaacagctca acaacagcct aaatttgaag acttgttagc     3780

tttgaatgag gatgtcattg gttggttaaa tatcccaggg actcatatgg attatcctct     3840

agttcaggga aaaacgaatt tagagtatat taataaagca gttgatggca gcgttgccat     3900

gtctggtagt ttatttttag atacacggaa tcataatgat tttacggacg attactctct     3960

gatttatggc catcatatgg caggtaatgc catgtttggc gaaattccaa aatttttaaa     4020

aaaggatttt ttcaacaaac ataataaagc tatcattgaa acaaaagaga gaaaaaaact     4080

aaccgtcact atttttgctt gtctcaagac agatgccttt gaccagttag tttttaatcc     4140

taatgctatt accaatcaag accaacaaag gcagctcgtt gattatatca gtaaaagatc     4200

aaaacaattt aaacctgtta aattgaagca tcatacaaag tttgttgctt tttcaacgtg     4260

tgaaaatttt tctactgaca atcgtgttat cgttgtcggt actattcaag aataacgaaa     4320

ggaggagact tttgagaaaa tattggaaaa tgttattttc tgtcgtaatg atattaacca     4380

tgctggcctt taatcagact gttttagcaa aagacagcac tgttcaaact agcattagtg     4440

ttgaaaatgt cttagagaga gcaggcgata gtacctcatt ttcggttgca ttagaatcaa     4500

ttgatgcgat gaaaacaata gacgaaataa caattgctgg ttctggaaaa gcaagctttt     4560

cccctctgac cttcacaaca gttgggcaat atacttatcg tgtttaccag aagccttcac     4620

aaaataaaga ttatcaagca gatactactg tatttgacgt tcttgtctat gtgacctatg     4680

atgaagatgg gactctagtc gcaaaagtta tttctcgaag ggctggagac gaagaaaaat     4740

cagcgattac ttttaagccc aaacggttag taaaaccaat accgcctaga caacctgaca     4800

tccctaaaac cccattacca ttagctggtg aagtaaaaag tttattgggt atcttaagta     4860

tcgtattact ggggttacta gttcttcttt atgttaaaaa actgaagagt aggctataaa     4920

acccattttt aagagtcaca catttttagt tgctctattt ttataatgaa acttattgac     4980

atctccacag tcttgcttga ctttggagat gtttttctat gctgataggt ttttgtacca     5040

tataagataa tgattgatga aaagagtgtc ttgaattct                            5079


<210>  65
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  65
gcggatccga ccatatacac ggttgcagga                                        30


<210>  66
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide primer

<400>  66
cggctgcagt cttatatggt acaaaaacct atcagc                                 36


<210>  67
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  67
gagagagact cgagtagctt atgattctca ac                                     32


<210>  68
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  68
gagagagact cgagtacttc agaaaccgta taac                                   34


<210>  69
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  69

Met Lys Lys Asn Lys Leu Leu Leu Ala Thr Ala Ile Leu Ala Thr Ala 
1               5                   10                  15      


Leu Gly Thr Ala Ser Leu Asn Gln Asn Val Lys Ala Glu Thr Ala Gly 
            20                  25                  30          


Val Ile Asp Gly Ser Thr Leu Val Val Lys Lys Thr Phe Pro Ser Tyr 
        35                  40                  45              


Thr Asp Asp Lys Val Leu Met Pro Lys Ala Asp Tyr Thr Phe Lys Val 
    50                  55                  60                  


Glu Ala Asp Asp Asn Ala Lys Gly Lys Thr Lys Asp Gly Leu Asp Ile 
65                  70                  75                  80  


Lys Pro Gly Val Ile Asp Gly Leu Glu Asn Thr Lys Thr Ile His Tyr 
                85                  90                  95      


Gly Asn Ser Asp Lys Thr Thr Ala Lys Glu Lys Ser Val Asn Phe Asp 
            100                 105                 110         


Phe Ala Asn Val Lys Phe Pro Gly Val Gly Val Tyr Arg Tyr Thr Val 
        115                 120                 125             


Ser Glu Val Leu Glu Ser Gln Ala Val His Ala Ala His Ala Glu Ile 
    130                 135                 140                 


Asn Glu Ala Gly Arg Val Glu Ile Ala Tyr Asp Ser Gln Gln Trp Thr 
145                 150                 155                 160 


Val Asp Val Tyr Val Val Asn Arg Glu Asp Gly Gly Phe Glu Ala Lys 
                165                 170                 175     


Tyr Ile Val Ser Thr Glu Gly Gly Gln Ser Asp Lys Lys Pro Val Leu 
            180                 185                 190         


Phe Lys Asn Phe Phe Asp Thr Thr Ser Leu Lys Val Thr Lys Lys Val 
        195                 200                 205             


Thr Gly Asn Thr Gly Glu His Gln Arg Ser Phe Ser Phe Thr Leu Leu 
    210                 215                 220                 


Leu Thr Pro Asn Glu Cys Phe Glu Lys Gly Gln Val Val Asn Ile Leu 
225                 230                 235                 240 


Gln Gly Gly Glu Thr Lys Lys Val Val Ile Gly Glu Glu Tyr Ser Phe 
                245                 250                 255     


Thr Leu Lys Asp Lys Glu Ser Val Thr Leu Ser Gln Leu Pro Val Gly 
            260                 265                 270         


Ile Glu Tyr Lys Val Thr Glu Glu Asp Val Thr Lys Asp Gly Tyr Lys 
        275                 280                 285             


Thr Ser Ala Thr Leu Lys Asp Gly Asp Val Thr Asp Gly Tyr Asn Leu 
    290                 295                 300                 


Gly Asp Ser Lys Thr Thr Asp Lys Ser Thr Asp Glu Ile Val Val Thr 
305                 310                 315                 320 


Asn Lys Arg Asp Thr Gln Val Pro Thr Gly Val Val Gly Thr Leu Ala 
                325                 330                 335     


Pro Phe Ala Val Leu Ser Ile Val Ala Ile Gly Gly Val Ile Tyr Ile 
            340                 345                 350         


Thr Lys Arg Lys Lys 
        355         


<210>  70
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  70

Met Lys Lys Asn Lys Leu Leu Leu Ala Thr Ala Ile Leu Ala Thr Ala 
1               5                   10                  15      


Leu Gly Thr Ala Ser Leu Asn Gln Asn Val Lys Ala Glu Thr Ala Gly 
            20                  25                  30          


Val Ile Asp Gly Ser Thr Leu Val Val Lys Lys Thr Phe Pro Ser Tyr 
        35                  40                  45              


Thr Asp Asp Lys Val Leu Met Pro Lys Ala Asp Tyr Thr Phe Lys Val 
    50                  55                  60                  


Glu Ala Asp Asp Asn Ala Lys Gly Lys Thr Lys Asp Gly Leu Asp Ile 
65                  70                  75                  80  


Lys Pro Gly Val Ile Asp Gly Leu Glu Asn Thr Lys Thr Ile His Tyr 
                85                  90                  95      


Gly Asn Ser Asp Lys Thr Thr Ala Lys Glu Lys Ser Val Asn Phe Asp 
            100                 105                 110         


Phe Ala Asn Val Lys Phe Pro Gly Val Gly Val Tyr Arg Tyr Thr Val 
        115                 120                 125             


Ser Glu Val Leu Glu Ser Gln Ala Val His Ala Ala His Ala Glu Ile 
    130                 135                 140                 


Asn Glu Ala Gly Arg Val Glu Ser Gln Ala Val His Ala Ala His Ala 
145                 150                 155                 160 


Glu Ile Asn Glu Ala Gly Arg Val Glu Ile Ala Tyr Asp Ser Gln Gln 
                165                 170                 175     


Trp Thr Val Asp Val Tyr Val Val Asn Arg Glu Asp Gly Gly Phe Glu 
            180                 185                 190         


Ala Lys Tyr Ile Val Ser Thr Glu Gly Gly Gln Ser Asp Lys Lys Pro 
        195                 200                 205             


Val Leu Phe Lys Asn Phe Phe Asp Thr Thr Ser Leu Lys Val Thr Lys 
    210                 215                 220                 


Lys Val Thr Gly Asn Thr Gly Glu His Gln Arg Ser Phe Ser Phe Thr 
225                 230                 235                 240 


Leu Leu Leu Thr Pro Asn Glu Cys Phe Glu Lys Gly Gln Val Val Asn 
                245                 250                 255     


Ile Leu Gln Gly Gly Glu Thr Lys Lys Val Val Ile Gly Glu Glu Tyr 
            260                 265                 270         


Ser Phe Thr Leu Lys Asp Lys Glu Ser Val Thr Leu Ser Gln Leu Pro 
        275                 280                 285             


Val Gly Ile Glu Tyr Lys Val Thr Glu Glu Asp Val Thr Lys Asp Gly 
    290                 295                 300                 


Tyr Lys Thr Ser Ala Thr Leu Lys Asp Gly Asp Val Thr Asp Gly Tyr 
305                 310                 315                 320 


Asn Leu Gly Asp Ser Lys Thr Thr Asp Lys Ser Thr Asp Glu Ile Val 
                325                 330                 335     


Val Thr Asn Lys Arg Asp Thr Gln Val Pro Thr Gly Val Val Gly Thr 
            340                 345                 350         


Leu Ala Pro Phe Ala Val Leu Ser Ile Val Ala Ile Gly Gly Val Ile 
        355                 360                 365             


Tyr Ile Thr Lys Arg Lys Lys 
    370                 375 


<210>  71
<211>  48
<212>  DNA
<213>  Gallus gallus

<400>  71
acagaatgga cttcatctaa tgttatggaa gagcgtaaaa ttaaagtt                    48


<210>  72
<211>  16
<212>  PRT
<213>  Gallus gallus

<400>  72

Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile Lys Val 
1               5                   10                  15      


<210>  73
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  73

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Leu Glu Thr Glu Trp Thr Ser Ser Asn Val 
        115                 120                 125             


Met Glu Glu Arg Lys Ile Lys Val Leu Glu Gly Val Ser Tyr Asp Thr 
    130                 135                 140                 


Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln Gln 
145                 150                 155                 160 


Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys Val 
                165                 170                 175     


Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val Lys 
            180                 185                 190         


Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn Phe 
        195                 200                 205             


Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys Val 
    210                 215                 220                 


Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr Glu 
225                 230                 235                 240 


Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu Ser 
                245                 250                 255     


Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr Glu 
            260                 265                 270         


Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser Pro 
        275                 280                 285             


Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln Glu 
    290                 295                 300                 


Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp 
305                 310                 315                 320 


Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr Ile Ala 
                325                 330                 335     


Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys Lys Lys 
            340                 345                 350         


Asn Ala 
        


