                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF BRITISH COLUMBIA
       ONG, Christopher  J.
       GLEAVE, Martin E.
       PEACOCK, James
 
<120>  B1SP FUSION PROTEIN THERAPEUTICS, METHODS, AND USES

<130>  P1354PC00

<140>  PCT/CA2016/000182
<141>  2016-06-29

<150>  62/185,772
<151>  2015-06-29

<160>  167   

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            20                  25                  30          


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln 
        35                  40          


<210>  2
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1SP Fusion


<220>
<221>  Fusion Protein B1SP
<222>  (1)..(778)

<400>  2

Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      


Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          


Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              


Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  


Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  


Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      


Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         


Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             


Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 


Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 


Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     


Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         


Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             


Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 


Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 


Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     


His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         


Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             


His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 


Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 


Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     


Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         


Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             


Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 


Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 


Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     


Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         


Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             


Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 


His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 


Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             


Pro Glu Leu Gly Cys Leu Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
545                 550                 555                 560 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                565                 570                 575     


Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            580                 585                 590         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        595                 600                 605             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    610                 615                 620                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
625                 630                 635                 640 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                645                 650                 655     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            660                 665                 670         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        675                 680                 685             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    690                 695                 700                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
705                 710                 715                 720 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                725                 730                 735     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            740                 745                 750         


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr 
        755                 760                 765             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775             


<210>  3
<211>  2337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Sequence encoding B1SP fusion protein of SEQ ID NO:2


<220>
<221>  encoding B1SP Fusion DNA
<222>  (1)..(2337)

<400>  3
atgcctgctc tgggcccagc tcttctccag gctctctggg ccgggtgggt cctcaccctc       60

cagccccttc caccaactgc attcactccc aatggcacgt atctgcagca cctggcaagg      120

gaccccacct caggcaccct ctacctgggg gctaccaact tcctgttcca gctgagccct      180

gggctgcagc tggaggccac agtgtccacc ggccctgtgc tagacagcag ggactgcctg      240

ccacctgtga tgcctgatga gtgcccccag gcccagccta ccaacaaccc gaatcagctg      300

ctcctggtga gcccaggggc cctggtggta tgcgggagcg tgcaccaggg ggtctgtgaa      360

cagcggcgcc tggggcagct cgagcagctg ctgctgcggc cagagcggcc tggggacaca      420

caatatgtgg ctgccaatga tcctgcggtc agcacggtgg ggctggtagc ccagggcttg      480

gcaggggagc ccctcctgtt tgtggggcga ggatacacca gcaggggtgt ggggggtggc      540

attccaccca tcacaacccg ggccctgtgg ccgcccgacc cccaagctgc cttctcctat      600

gaggagacag ccaagctggc agtgggccgc ctctccgagt acagccacca cttcgtgagt      660

gcctttgcac gtggggccag cgcctacttc ctgttcctgc ggcgggacct gcaggctcag      720

tctagagctt ttcgtgccta tgtatctcga gtgtgtctcc gggaccagca ctactactcc      780

tatgtggagt tgcctctggc ctgcgaaggt ggccgctacg ggctgatcca ggctgcagct      840

gtggccacgt ccagggaggt ggcgcatggg gaggtgctct ttgcagcttt ctcctcggct      900

gcacccccca ctgtgggccg gcccccatcg gcggctgctg gggcatctgg agcctctgcc      960

ctctgtgcct tccccctgga tgaggtggac cggcttgcta atcgcacgcg agatgcctgc     1020

tacacccggg agggtcgtgc tgaggatggg accgaggtgg cctacatcga gtatgatgtc     1080

aattctgact gtgcacagct gccagtggac accctggatg cttatccctg tggctcagac     1140

cacacgccca gccccatggc cagccgggtc ccgctggaag ccacaccaat tctggagtgg     1200

ccagggattc agctaacagc tgtggcagtc accatggaag atggacacac catcgctttc     1260

ctgggtgata gtcaagggca gctgcacagg gtctacttgg gcccagggag cgatggccac     1320

ccatactcca cacagagcat ccagcagggg tctgcagtga gcagagacct cacctttgat     1380

gggacctttg agcacctgta tgtcatgacc cagagcacac ttctgaaggt tcctgtggct     1440

tcctgtgctc agcacctgga ctgtgcatct tgccttgctc acagggaccc atactgtggg     1500

tggtgcgtgc tccttggcag gtgcagtcgc cgttctgagt gctcgagggg ccagggccca     1560

gagcagtggc tatggagctt ccagcctgag ctgggctgtc tgggatccgg tggcggttcc     1620

ggtggtggag gcggaagcgg cggtggagga tcagacaaaa ctcacacatg cccaccgtgc     1680

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1740

caactgatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1800

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1860

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1920

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1980

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     2040

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     2100

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     2160

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     2220

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgctgcat     2280

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        2337


<210>  4
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB-L-SDPSI or ALB SRGLI


<220>
<221>  Fusion Protein ALB-L-SDPSI Albumin
<222>  (1)..(1182)

<400>  4

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys His His His His His His His His Met Lys Trp Val 
            20                  25                  30          


Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr Ser Arg Gly 
        35                  40                  45              


Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
    50                  55                  60                  


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
65                  70                  75                  80  


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
                85                  90                  95      


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
            100                 105                 110         


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
        115                 120                 125             


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
    130                 135                 140                 


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
145                 150                 155                 160 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
                165                 170                 175     


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
            180                 185                 190         


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
        195                 200                 205             


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
    210                 215                 220                 


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
225                 230                 235                 240 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
                245                 250                 255     


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
            260                 265                 270         


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
        275                 280                 285             


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
    290                 295                 300                 


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
305                 310                 315                 320 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
                325                 330                 335     


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
            340                 345                 350         


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
        355                 360                 365             


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
    370                 375                 380                 


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
385                 390                 395                 400 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
                405                 410                 415     


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
            420                 425                 430         


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
        435                 440                 445             


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
    450                 455                 460                 


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
465                 470                 475                 480 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
                485                 490                 495     


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
            500                 505                 510         


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
        515                 520                 525             


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
    530                 535                 540                 


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
545                 550                 555                 560 


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
                565                 570                 575     


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
            580                 585                 590         


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
        595                 600                 605             


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
    610                 615                 620                 


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
                645                 650                 655     


Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr Phe Asp Glu Leu Arg Glu 
            660                 665                 670         


Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser His His Pro Leu Asp Tyr 
        675                 680                 685             


Arg Ile Leu Leu Met Asp Glu Asp Gln Asp Arg Ile Tyr Val Gly Ser 
    690                 695                 700                 


Lys Asp His Ile Leu Ser Leu Asn Ile Asn Asn Ile Ser Gln Glu Ala 
705                 710                 715                 720 


Leu Ser Val Phe Trp Pro Ala Ser Thr Ile Lys Val Glu Glu Cys Lys 
                725                 730                 735     


Met Ala Gly Lys Asp Pro Thr His Gly Cys Gly Asn Phe Val Arg Val 
            740                 745                 750         


Ile Gln Thr Phe Asn Arg Thr His Leu Tyr Val Cys Gly Ser Gly Ala 
        755                 760                 765             


Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg Gly Arg Arg Ser Glu Asp 
    770                 775                 780                 


Gln Val Phe Met Ile Asp Ser Lys Cys Glu Ser Gly Lys Gly Arg Cys 
785                 790                 795                 800 


Ser Phe Asn Pro Asn Val Asn Thr Val Ser Val Met Ile Asn Glu Glu 
                805                 810                 815     


Leu Phe Ser Gly Met Tyr Ile Asp Phe Met Gly Thr Asp Ala Ala Ile 
            820                 825                 830         


Phe Arg Ser Leu Thr Lys Arg Asn Ala Val Arg Thr Asp Gln His Asn 
        835                 840                 845             


Ser Lys Trp Leu Ser Glu Pro Met Phe Val Asp Ala His Val Ile Pro 
    850                 855                 860                 


Asp Gly Thr Asp Pro Asn Asp Ala Lys Val Tyr Phe Phe Phe Lys Glu 
865                 870                 875                 880 


Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys Gln Ile His Ser Met Ile 
                885                 890                 895     


Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly Leu Arg Ser Leu Val Asn 
            900                 905                 910         


Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Thr Asp 
        915                 920                 925             


Glu Asp Gly Pro Glu Thr His Phe Asp Glu Leu Glu Asp Val Phe Leu 
    930                 935                 940                 


Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu Val Tyr Gly Ile Phe Thr 
945                 950                 955                 960 


Thr Ser Ser Ser Val Phe Lys Gly Ser Ala Val Cys Val Tyr His Leu 
                965                 970                 975     


Ser Asp Ile Gln Thr Val Phe Asn Gly Pro Phe Ala His Lys Glu Gly 
            980                 985                 990         


Pro Asn His Gln Leu Ile Ser Tyr  Gln Gly Arg Ile Pro  Tyr Pro Arg 
        995                 1000                 1005             


Pro Gly  Thr Cys Pro Gly Gly  Ala Phe Thr Pro Asn  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Glu Phe Pro Asp Asp  Val Val Thr Phe Ile  Arg Asn His 
    1025                 1030                 1035             


Pro Leu  Met Tyr Asn Ser Ile  Tyr Pro Ile His Lys  Arg Pro Leu 
    1040                 1045                 1050             


Ile Val  Arg Ile Gly Thr Asp  Tyr Lys Tyr Thr Lys  Ile Ala Val 
    1055                 1060                 1065             


Asp Arg  Val Asn Ala Ala Asp  Gly Arg Tyr His Val  Leu Phe Leu 
    1070                 1075                 1080             


Gly Thr  Asp Arg Gly Thr Val  Gln Lys Val Val Val  Leu Pro Thr 
    1085                 1090                 1095             


Asn Asn  Ser Val Ser Gly Glu  Leu Ile Leu Glu Glu  Leu Glu Val 
    1100                 1105                 1110             


Phe Lys  Asn His Ala Pro Ile  Thr Thr Met Lys Ile  Ser Ser Lys 
    1115                 1120                 1125             


Lys Gln  Gln Leu Tyr Val Ser  Ser Asn Glu Gly Val  Ser Gln Val 
    1130                 1135                 1140             


Ser Leu  His Arg Cys His Ile  Tyr Gly Thr Ala Cys  Ala Asp Cys 
    1145                 1150                 1155             


Cys Leu  Ala Arg Asp Pro Tyr  Cys Ala Trp Asp Gly  His Ser Cys 
    1160                 1165                 1170             


Ser Arg  Phe Tyr Pro Thr Gly  Lys Arg 
    1175                 1180         


<210>  5
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDPSI-L-ALB


<220>
<221>  Fusion Protein SDPSI-L-ALB
<222>  (1)..(1157)

<400>  5

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
                565                 570                 575     


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
            580                 585                 590         


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
        595                 600                 605             


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
    610                 615                 620                 


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
625                 630                 635                 640 


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
                645                 650                 655     


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
            660                 665                 670         


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
        675                 680                 685             


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
    690                 695                 700                 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
705                 710                 715                 720 


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
                725                 730                 735     


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
            740                 745                 750         


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
        755                 760                 765             


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
    770                 775                 780                 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
785                 790                 795                 800 


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
                805                 810                 815     


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
            820                 825                 830         


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
        835                 840                 845             


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
    850                 855                 860                 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
865                 870                 875                 880 


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
                885                 890                 895     


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
            900                 905                 910         


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
        915                 920                 925             


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
    930                 935                 940                 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
945                 950                 955                 960 


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
                965                 970                 975     


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
            980                 985                 990         


Asn Leu Gly Lys Val Gly Ser Lys  Cys Cys Lys His Pro  Glu Ala Lys 
        995                 1000                 1005             


Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
    1010                 1015                 1020             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1025                 1030                 1035             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1040                 1045                 1050             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1055                 1060                 1065             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1070                 1075                 1080             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1085                 1090                 1095             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1100                 1105                 1110             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1115                 1120                 1125             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1130                 1135                 1140             


Gln Ala  Ala Leu Gly Leu His  His His His His His  His His 
    1145                 1150                 1155         


<210>  6
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEMA3C:FC full length SEMA3C with mutations in two furin cleavage
       sites, a linker and Fc region at the C terminus


<220>
<221>  SEMA3C:FC full length SEMA3C with mutations in two furin cleavage
       sites, a linker and Fc region at the C terminus
<222>  (1)..(983)

<400>  6

Met Ala Phe Arg Thr Ile Cys Val Leu Val Gly Val Phe Ile Cys Ser 
1               5                   10                  15      


Ile Cys Val Lys Gly Ser Ser Gln Pro Gln Ala Arg Val Tyr Leu Thr 
            20                  25                  30          


Phe Asp Glu Leu Arg Glu Thr Lys Thr Ser Glu Tyr Phe Ser Leu Ser 
        35                  40                  45              


His His Pro Leu Asp Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp 
    50                  55                  60                  


Arg Ile Tyr Val Gly Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn 
65                  70                  75                  80  


Asn Ile Ser Gln Glu Ala Leu Ser Val Phe Trp Pro Ala Ser Thr Ile 
                85                  90                  95      


Lys Val Glu Glu Cys Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys 
            100                 105                 110         


Gly Asn Phe Val Arg Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr 
        115                 120                 125             


Val Cys Gly Ser Gly Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg 
    130                 135                 140                 


Gly Arg Arg Ser Glu Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu 
145                 150                 155                 160 


Ser Gly Lys Gly Arg Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser 
                165                 170                 175     


Val Met Ile Asn Glu Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met 
            180                 185                 190         


Gly Thr Asp Ala Ala Ile Phe Arg Ser Leu Thr Lys Arg Asn Ala Val 
        195                 200                 205             


Arg Thr Asp Gln His Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val 
    210                 215                 220                 


Asp Ala His Val Ile Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val 
225                 230                 235                 240 


Tyr Phe Phe Phe Lys Glu Lys Leu Thr Asp Asn Asn Arg Ser Thr Lys 
                245                 250                 255     


Gln Ile His Ser Met Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly 
            260                 265                 270         


Leu Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
        275                 280                 285             


Val Cys Ser Val Thr Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu 
    290                 295                 300                 


Leu Glu Asp Val Phe Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu 
305                 310                 315                 320 


Val Tyr Gly Ile Phe Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala 
                325                 330                 335     


Val Cys Val Tyr His Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro 
            340                 345                 350         


Phe Ala His Lys Glu Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly 
        355                 360                 365             


Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr 
    370                 375                 380                 


Pro Asn Met Arg Thr Thr Lys Glu Phe Pro Asp Asp Val Val Thr Phe 
385                 390                 395                 400 


Ile Arg Asn His Pro Leu Met Tyr Asn Ser Ile Tyr Pro Ile His Lys 
                405                 410                 415     


Arg Pro Leu Ile Val Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile 
            420                 425                 430         


Ala Val Asp Arg Val Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe 
        435                 440                 445             


Leu Gly Thr Asp Arg Gly Thr Val Gln Lys Val Val Val Leu Pro Thr 
    450                 455                 460                 


Asn Asn Ser Val Ser Gly Glu Leu Ile Leu Glu Glu Leu Glu Val Phe 
465                 470                 475                 480 


Lys Asn His Ala Pro Ile Thr Thr Met Lys Ile Ser Ser Lys Lys Gln 
                485                 490                 495     


Gln Leu Tyr Val Ser Ser Asn Glu Gly Val Ser Gln Val Ser Leu His 
            500                 505                 510         


Arg Cys His Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
        515                 520                 525             


Asp Pro Tyr Cys Ala Trp Asp Gly His Ser Cys Ser Arg Phe Tyr Pro 
    530                 535                 540                 


Thr Gly Lys Arg Arg Ser Ala Ala Gln Asp Val Arg His Gly Asn Pro 
545                 550                 555                 560 


Leu Thr Gln Cys Arg Gly Phe Asn Leu Lys Ala Tyr Arg Asn Ala Ala 
                565                 570                 575     


Glu Ile Val Gln Tyr Gly Val Lys Asn Asn Thr Thr Phe Leu Glu Cys 
            580                 585                 590         


Ala Pro Lys Ser Pro Gln Ala Ser Ile Lys Trp Leu Leu Gln Lys Asp 
        595                 600                 605             


Lys Asp Ala Ala Lys Glu Val Lys Leu Asn Glu Arg Ile Ile Ala Thr 
    610                 615                 620                 


Ser Gln Gly Leu Leu Ile Arg Ser Val Gln Gly Ser Asp Gln Gly Leu 
625                 630                 635                 640 


Tyr His Cys Ile Ala Thr Glu Asn Ser Phe Lys Gln Thr Ile Ala Lys 
                645                 650                 655     


Ile Asn Phe Lys Val Leu Asp Ser Glu Met Val Ala Val Val Thr Asp 
            660                 665                 670         


Lys Trp Ser Pro Trp Thr Trp Ala Ser Ser Val Arg Ala Leu Pro Phe 
        675                 680                 685             


His Pro Lys Asp Ile Met Gly Ala Phe Ser His Ser Glu Met Gln Met 
    690                 695                 700                 


Ile Asn Gln Tyr Cys Lys Asp Thr Arg Gln Gln His Gln Gln Gly Asp 
705                 710                 715                 720 


Glu Ser Gln Lys Met Arg Gly Asp Tyr Gly Lys Leu Lys Ala Leu Ile 
                725                 730                 735     


Asn Ser Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His 
            740                 745                 750         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        755                 760                 765             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    770                 775                 780                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
785                 790                 795                 800 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                805                 810                 815     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            820                 825                 830         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        835                 840                 845             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    850                 855                 860                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
865                 870                 875                 880 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                885                 890                 895     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            900                 905                 910         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        915                 920                 925             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    930                 935                 940                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
945                 950                 955                 960 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His 
                965                 970                 975     


His His His His His His His 
            980             


<210>  7
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scramble siRNA


<220>
<221>  siRNA scamrable
<222>  (1)..(23)

<400>  7
aucaaacugu ugucagcgcu guu                                               23


<210>  8
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  8
ccggguggaa uuuauccuug auu                                               23


<210>  9
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  9
accacgguca cccggauucu u                                                 21


<210>  10
<211>  1545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1R4 Fusion Protein


<220>
<221>  B1R4 Protein Fusion
<222>  (1)..(1545)

<400>  10

Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      


Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          


Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              


Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  


Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  


Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      


Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         


Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             


Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 


Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 


Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     


Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         


Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             


Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 


Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 


Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     


His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         


Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             


His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 


Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 


Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     


Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         


Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             


Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 


Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 


Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     


Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         


Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             


Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 


His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 


Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             


Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 


Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 


Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     


Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         


Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             


Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 


Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 


Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     


Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         


Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             


Gly Pro Ser Pro Ser Pro Pro Thr Ala Pro Lys Ala Leu Ala Thr Pro 
    690                 695                 700                 


Ala Pro Asp Thr Leu Pro Val Glu Pro Gly Ala Pro Ser Thr Ala Thr 
705                 710                 715                 720 


Ala Ser Asp Ile Ser Pro Gly Ala Ser Pro Ser Leu Leu Ser Pro Trp 
                725                 730                 735     


Gly Pro Trp Ala Gly Ser Gly Ser Ile Ser Ser Pro Gly Ser Thr Gly 
            740                 745                 750         


Ser Pro Leu His Glu Glu Pro Ser Pro Pro Ser Pro Gln Asn Gly Pro 
        755                 760                 765             


Gly Thr Ala Val Pro Ala Pro Thr Asp Phe Arg Pro Ser Ala Thr Pro 
    770                 775                 780                 


Glu Asp Leu Leu Ala Ser Pro Leu Ser Pro Ser Glu Val Ala Ala Val 
785                 790                 795                 800 


Pro Pro Ala Asp Pro Gly Pro Glu Ala Leu His Pro Thr Val Pro Leu 
                805                 810                 815     


Asp Leu Pro Pro Ala Thr Val Pro Ala Thr Thr Phe Pro Gly Ala Met 
            820                 825                 830         


Gly Ser Val Lys Pro Ala Leu Asp Trp Leu Thr Arg Glu Gly Gly Glu 
        835                 840                 845             


Leu Pro Glu Ala Asp Glu Trp Thr Gly Gly Asp Ala Pro Ala Phe Ser 
    850                 855                 860                 


Thr Ser Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu Leu Glu Gly 
865                 870                 875                 880 


Pro Pro Ala Pro Leu Ile Leu Pro Ser Ser Leu Asp Tyr Gln Tyr Asp 
                885                 890                 895     


Thr Pro Gly Leu Trp Glu Leu Glu Glu Ala Thr Leu Gly Ala Ser Ser 
            900                 905                 910         


Cys Pro Cys Val Glu Ser Val Gln Gly Ser Thr Leu Met Pro Val His 
        915                 920                 925             


Val Glu Arg Glu Ile Arg Leu Leu Gly Arg Asn Leu His Leu Phe Gln 
    930                 935                 940                 


Asp Gly Pro Gly Asp Asn Glu Cys Val Met Glu Leu Glu Gly Leu Glu 
945                 950                 955                 960 


Val Val Val Glu Ala Arg Val Glu Cys Glu Pro Pro Pro Asp Thr Gln 
                965                 970                 975     


Cys His Val Thr Cys Gln Gln His Gln Leu Ser Tyr Glu Ala Leu Gln 
            980                 985                 990         


Pro Glu Leu Arg Val Gly Leu Phe  Leu Arg Arg Ala Gly  Arg Leu Arg 
        995                 1000                 1005             


Val Asp  Ser Ala Glu Gly Leu  His Val Val Leu Tyr  Asp Cys Ser 
    1010                 1015                 1020             


Val Gly  His Gly Asp Cys Ser  Arg Cys Gln Thr Ala  Met Pro Gln 
    1025                 1030                 1035             


Tyr Gly  Cys Val Trp Cys Glu  Gly Glu Arg Pro Arg  Cys Val Thr 
    1040                 1045                 1050             


Arg Glu  Ala Cys Gly Glu Ala  Glu Ala Val Ala Thr  Gln Cys Pro 
    1055                 1060                 1065             


Ala Pro  Leu Ile His Ser Val  Glu Pro Leu Thr Gly  Pro Val Asp 
    1070                 1075                 1080             


Gly Gly  Thr Arg Val Thr Ile  Arg Gly Ser Asn Leu  Gly Gln His 
    1085                 1090                 1095             


Val Gln  Asp Val Leu Gly Met  Val Thr Val Ala Gly  Val Pro Cys 
    1100                 1105                 1110             


Ala Val  Asp Ala Gln Glu Tyr  Glu Val Ser Ser Ser  Leu Val Cys 
    1115                 1120                 1125             


Ile Thr  Gly Ala Ser Gly Glu  Glu Val Ala Gly Ala  Thr Ala Val 
    1130                 1135                 1140             


Glu Val  Pro Gly Arg Gly Arg  Gly Val Ser Glu His  Asp Phe Ala 
    1145                 1150                 1155             


Tyr Gln  Asp Pro Lys Val His  Ser Ile Phe Pro Ala  Arg Gly Pro 
    1160                 1165                 1170             


Arg Ala  Gly Gly Thr Arg Leu  Thr Leu Asn Gly Ser  Lys Leu Leu 
    1175                 1180                 1185             


Thr Gly  Arg Leu Glu Asp Ile  Arg Val Val Val Gly  Asp Gln Pro 
    1190                 1195                 1200             


Cys His  Leu Leu Pro Glu Gln  Gln Ser Glu Gln Leu  Arg Cys Glu 
    1205                 1210                 1215             


Thr Ser  Pro Arg Pro Thr Pro  Ala Thr Leu Pro Val  Ala Val Trp 
    1220                 1225                 1230             


Phe Gly  Ala Thr Glu Arg Arg  Leu Gln Arg Gly Gln  Phe Lys Tyr 
    1235                 1240                 1245             


Thr Leu  Asp Pro Asn Ile Thr  Ser Ala Gly Pro Thr  Lys Ser Phe 
    1250                 1255                 1260             


Leu Ser  Gly Gly Arg Glu Ile  Cys Val Arg Gly Gln  Asn Leu Asp 
    1265                 1270                 1275             


Val Val  Gln Thr Pro Arg Ile  Arg Val Thr Val Val  Ser Arg Met 
    1280                 1285                 1290             


Leu Gln  Pro Ser Gln Gly Leu  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1295                 1300                 1305             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Asp Lys  Thr His Thr 
    1310                 1315                 1320             


Cys Pro  Pro Cys Pro Ala Pro  Glu Leu Leu Gly Gly  Pro Ser Val 
    1325                 1330                 1335             


Phe Leu  Phe Pro Pro Lys Pro  Lys Asp Gln Leu Met  Ile Ser Arg 
    1340                 1345                 1350             


Thr Pro  Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
    1355                 1360                 1365             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1370                 1375                 1380             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1385                 1390                 1395             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1400                 1405                 1410             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1415                 1420                 1425             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1430                 1435                 1440             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Glu Glu  Met Thr Lys 
    1445                 1450                 1455             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1460                 1465                 1470             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1475                 1480                 1485             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1490                 1495                 1500             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1505                 1510                 1515             


Asn Val  Phe Ser Cys Ser Val  Leu His Glu Ala Leu  His Asn His 
    1520                 1525                 1530             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1535                 1540                 1545 


<210>  11
<211>  442
<212>  PRT
<213>  Gallus gallus domesticus

<400>  11

Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg Leu Tyr Val Gly 
1               5                   10                  15      


Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn Ile Lys Glu Tyr 
            20                  25                  30          


Gln Lys Ile Val Trp Pro Val Ser His Ser Arg Arg Asp Glu Cys Lys 
        35                  40                  45              


Trp Ala Gly Lys Asp Ile Leu Arg Glu Cys Ala Asn Phe Ile Lys Val 
    50                  55                  60                  


Leu Lys Thr Tyr Asn Gln Thr His Leu Tyr Ala Cys Gly Thr Gly Ala 
65                  70                  75                  80  


Phe His Pro Met Cys Thr Tyr Ile Glu Val Gly Ser His Pro Glu Asp 
                85                  90                  95      


Asn Ile Phe Arg Met Glu Asp Ser His Phe Glu Asn Gly Arg Gly Lys 
            100                 105                 110         


Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu Leu Val Asp Gly 
        115                 120                 125             


Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly Arg Asp Phe Ala 
    130                 135                 140                 


Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg Thr Glu Gln His 
145                 150                 155                 160 


Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser Ala His Leu Ile 
                165                 170                 175     


Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Ile Tyr Phe Phe Phe Arg 
            180                 185                 190         


Glu Asn Ala Ile Asp Gly Glu His Thr Gly Lys Ala Thr His Ala Arg 
        195                 200                 205             


Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His Arg Ser Leu Val 
    210                 215                 220                 


Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Val Pro 
225                 230                 235                 240 


Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu Gln Asp Val Phe 
                245                 250                 255     


Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val Tyr Gly Val Phe 
            260                 265                 270         


Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val Cys Met Tyr Ser 
        275                 280                 285             


Met Thr Asp Val Arg Arg Val Phe Leu Gly Pro Tyr Ala His Arg Asp 
    290                 295                 300                 


Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg Val Pro Tyr Pro 
305                 310                 315                 320 


Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly Phe Asp Ser Thr 
                325                 330                 335     


Lys Asp Leu Pro Asp Glu Val Ile Thr Phe Ala Arg Ser His Pro Ala 
            340                 345                 350         


Met Tyr Asn Pro Val Phe Pro Ile Asn Ser Arg Pro Ile Met Ile Lys 
        355                 360                 365             


Thr Asp Val Asp Tyr Gln Phe Thr Gln Ile Val Val Asp Arg Val Asp 
    370                 375                 380                 


Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly Thr Asp Ile Gly 
385                 390                 395                 400 


Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr Trp His Glu Leu 
                405                 410                 415     


Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg Glu Pro Thr Val 
            420                 425                 430         


Ile Ser Ala Met Lys Ile Ser Thr Lys Gln 
        435                 440         


<210>  12
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu His Thr Met Leu Leu Asp Glu Tyr Gln Glu Arg Leu Phe Val Gly 
1               5                   10                  15      


Gly Arg Asp Leu Val Tyr Ser Leu Ser Leu Glu Arg Ile Ser Asp Gly 
            20                  25                  30          


Tyr Lys Glu Ile His Trp Pro Ser Thr Ala Leu Lys Met Glu Glu Cys 
        35                  40                  45              


Ile Met Lys Gly Lys Asp Ala Gly Glu Cys Ala Asn Tyr Val Arg Val 
    50                  55                  60                  


Leu His His Tyr Asn Arg Thr His Leu Leu Thr Cys Gly Thr Gly Ala 
65                  70                  75                  80  


Phe Asp Pro Val Cys Ala Phe Ile Arg Val Gly Tyr His Leu Glu Asp 
                85                  90                  95      


Pro Leu Phe His Leu Glu Ser Pro Arg Ser Glu Arg Gly Arg Gly Arg 
            100                 105                 110         


Cys Pro Phe Asp Pro Ser Ser Ser Phe Ile Ser Thr Leu Ile Gly Ser 
        115                 120                 125             


Glu Leu Phe Ala Gly Leu Tyr Ser Asp Tyr Trp Ser Arg Asp Ala Ala 
    130                 135                 140                 


Ile Phe Arg Ser Met Gly Arg Leu Ala His Ile Arg Thr Glu His Asp 
145                 150                 155                 160 


Asp Glu Arg Leu Leu Lys Glu Pro Lys Phe Val Gly Ser Tyr Met Ile 
                165                 170                 175     


Pro Asp Asn Glu Asp Arg Asp Asp Asn Lys Val Tyr Phe Phe Phe Thr 
            180                 185                 190         


Glu Lys Ala Leu Glu Ala Glu Asn Asn Ala His Ala Ile Tyr Thr Arg 
        195                 200                 205             


Val Gly Arg Leu Cys Val Asn Asp Val Gly Gly Gln Arg Ile Leu Val 
    210                 215                 220                 


Asn Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Pro 
225                 230                 235                 240 


Gly Met Asn Gly Ile Asp Thr Tyr Phe Asp Glu Leu Glu Asp Val Phe 
                245                 250                 255     


Leu Leu Pro Thr Arg Asp His Lys Asn Pro Val Ile Phe Gly Leu Phe 
            260                 265                 270         


Asn Thr Thr Ser Asn Ile Phe Arg Gly His Ala Ile Cys Val Tyr His 
        275                 280                 285             


Met Ser Ser Ile Arg Ala Ala Phe Asn Gly Pro Tyr Ala His Lys Glu 
    290                 295                 300                 


Gly Pro Glu Tyr His Trp Ser Val Tyr Glu Gly Lys Val Pro Tyr Pro 
305                 310                 315                 320 


Arg Pro Gly Ser Cys Ala Ser Lys Val Asn Gly Gly Arg Tyr Gly Thr 
                325                 330                 335     


Thr Lys Asp Tyr Pro Asp Asp Ala Ile Arg Phe Ala Arg Ser His Pro 
            340                 345                 350         


Leu Met Tyr Gln Ala Ile Lys Pro Ala His Lys Lys Pro Ile Leu Val 
        355                 360                 365             


Lys Thr Asp Gly Lys Tyr Asn Leu Lys Gln Ile Ala Val Asp Arg Val 
    370                 375                 380                 


Glu Ala Glu Asp Gly Gln Tyr Asp Val Leu Phe Ile Gly Thr Asp Asn 
385                 390                 395                 400 


Gly Ile Val Leu Lys Val Ile Thr Ile Tyr Asn Gln Glu Met Glu Ser 
                405                 410                 415     


Met Glu Glu Val Ile Leu Glu Glu Leu Gln Ile Phe Lys Asp Pro Val 
            420                 425                 430         


Pro Ile Ile Ser Met Glu Ile Ser Ser Lys Arg 
        435                 440             


<210>  13
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  13

Tyr Arg Ile Leu Leu Met Asp Glu Asp Gln Asp Arg Ile Tyr Val Gly 
1               5                   10                  15      


Ser Lys Asp His Ile Leu Ser Leu Asn Ile Asn Asn Ile Ser Gln Glu 
            20                  25                  30          


Pro Leu Ser Val Phe Trp Pro Ala Ser Thr Ile Lys Val Glu Glu Cys 
        35                  40                  45              


Lys Met Ala Gly Lys Asp Pro Thr His Gly Cys Gly Asn Phe Val Arg 
    50                  55                  60                  


Val Ile Gln Thr Phe Asn Arg Thr His Leu Tyr Val Cys Gly Ser Gly 
65                  70                  75                  80  


Ala Phe Ser Pro Val Cys Thr Tyr Leu Asn Arg Gly Arg Arg Ser Glu 
                85                  90                  95      


Asp Gln Val Phe Met Ile Asp Ser Lys Cys Glu Ser Gly Lys Gly Arg 
            100                 105                 110         


Cys Ser Phe Asn Pro Asn Val Asn Thr Val Ser Val Met Ile Asn Glu 
        115                 120                 125             


Glu Leu Phe Ser Gly Met Tyr Ile Asp Phe Met Gly Thr Asp Ala Ala 
    130                 135                 140                 


Ile Phe Arg Ser Leu Thr Lys Arg Met Gln Leu Arg Thr Asp Gln His 
145                 150                 155                 160 


Asn Ser Lys Trp Leu Ser Glu Pro Met Phe Val Asp Ala His Val Ile 
                165                 170                 175     


Pro Asp Gly Thr Asp Pro Asn Asp Ala Lys Val Tyr Phe Phe Phe Lys 
            180                 185                 190         


Glu Arg Leu Thr Asp Asn Asn Arg Ser Thr Lys Gln Ile His Ser Met 
        195                 200                 205             


Ile Ala Arg Ile Cys Pro Asn Asp Thr Gly Gly Gln Arg Ser Leu Val 
    210                 215                 220                 


Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Thr 
225                 230                 235                 240 


Asp Glu Asp Gly Pro Glu Thr His Phe Asp Glu Leu Glu Asp Val Phe 
                245                 250                 255     


Leu Leu Glu Thr Asp Asn Pro Arg Thr Thr Leu Val Tyr Gly Ile Phe 
            260                 265                 270         


Thr Thr Ser Ser Ser Val Phe Lys Gly Ser Ala Val Cys Val Tyr His 
        275                 280                 285             


Leu Ser Asp Ile Gln Thr Val Phe Asn Gly Pro Phe Ala His Lys Glu 
    290                 295                 300                 


Gly Pro Asn His Gln Leu Ile Ser Tyr Gln Gly Arg Ile Pro Tyr Pro 
305                 310                 315                 320 


Arg Pro Gly Thr Cys Pro Gly Gly Ala Phe Thr Pro Asn Met Arg Thr 
                325                 330                 335     


Thr Lys Asp Phe Pro Asp Asp Val Val Thr Phe Ile Arg Asn His Pro 
            340                 345                 350         


Leu Met Tyr Asn Ser Ile Ser Pro Ile His Arg Arg Pro Leu Ile Val 
        355                 360                 365             


Arg Ile Gly Thr Asp Tyr Lys Tyr Thr Lys Ile Ala Val Asp Arg Val 
    370                 375                 380                 


Asn Ala Ala Asp Gly Arg Tyr His Val Leu Phe Leu Gly Thr Asp Arg 
385                 390                 395                 400 


Gly Thr Val Gln Lys Val 
                405     


<210>  14
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Gln Ala Met Tyr Leu Asp Glu Tyr Arg Asp Arg Leu Phe Leu Gly 
1               5                   10                  15      


Gly Leu Asp Ala Leu Tyr Ser Leu Arg Leu Asp Gln Ala Trp Pro Asp 
            20                  25                  30          


Pro Arg Glu Val Leu Trp Pro Pro Gln Pro Gly Gln Arg Glu Glu Cys 
        35                  40                  45              


Val Arg Lys Gly Arg Asp Pro Leu Thr Glu Cys Ala Asn Phe Val Arg 
    50                  55                  60                  


Val Leu Gln Pro His Asn Arg Thr His Leu Leu Ala Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Phe Gln Pro Thr Cys Ala Leu Ile Thr Val Gly His Arg Gly Glu 
                85                  90                  95      


His Val Leu His Leu Glu Pro Gly Ser Val Glu Ser Gly Arg Gly Arg 
            100                 105                 110         


Cys Pro His Glu Pro Ser Arg Pro Phe Ala Ser Thr Phe Ile Asp Gly 
        115                 120                 125             


Glu Leu Tyr Thr Gly Leu Thr Ala Asp Phe Leu Gly Arg Glu Ala Met 
    130                 135                 140                 


Ile Phe Arg Ser Gly Gly Pro Arg Pro Ala Leu Arg Ser Asp Ser Asp 
145                 150                 155                 160 


Gln Ser Leu Leu His Asp Pro Arg Phe Val Met Ala Ala Arg Ile Pro 
                165                 170                 175     


Glu Asn Ser Asp Gln Asp Asn Asp Lys Val Tyr Phe Phe Phe Ser Glu 
            180                 185                 190         


Thr Val Pro Ser Pro Asp Gly Gly Ser Asn His Val Thr Val Ser Arg 
        195                 200                 205             


Val Gly Arg Val Cys Val Asn Asp Ala Gly Gly Gln Arg Val Leu Val 
    210                 215                 220                 


Asn Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Pro 
225                 230                 235                 240 


Gly Pro Gly Gly Ala Glu Thr His Phe Asp Gln Leu Glu Asp Val Phe 
                245                 250                 255     


Leu Leu Trp Pro Lys Ala Gly Lys Ser Leu Glu Val Tyr Ala Leu Phe 
            260                 265                 270         


Ser Thr Val Ser Ala Val Phe Gln Gly Phe Ala Val Cys Val Tyr His 
        275                 280                 285             


Met Ala Asp Ile Trp Glu Val Phe Asn Gly Pro Phe Ala His Arg Asp 
    290                 295                 300                 


Gly Pro Gln His Gln Trp Gly Pro Tyr Gly Gly Lys Val Pro Phe Pro 
305                 310                 315                 320 


Arg Pro Gly Val Cys Pro Ser Lys Met Thr Ala Gln Pro Gly Arg Pro 
                325                 330                 335     


Phe Gly Ser Thr Lys Asp Tyr Pro Asp Glu Val Leu Gln Phe Ala Arg 
            340                 345                 350         


Ala His Pro Leu Met Phe Trp Pro Val Arg Pro Arg His Gly Arg Pro 
        355                 360                 365             


Val Leu Val Lys Thr His Leu Ala Gln Gln Leu His Gln Ile Val Val 
    370                 375                 380                 


Asp Arg Val Glu Ala Glu Asp Gly Thr Tyr Asp Val Ile Phe Leu Gly 
385                 390                 395                 400 


Thr Asp Ser Gly Ser Val Leu Lys Val Ile Ala Leu Gln Ala Gly Gly 
                405                 410                 415     


Ser Ala Glu Pro Glu Glu Val Val Leu Glu Glu Leu Gln Val Phe Lys 
            420                 425                 430         


Val Pro Thr Pro Ile Thr Glu Met Glu Ile Ser Val Lys Arg 
        435                 440                 445     


<210>  15
<211>  446
<212>  PRT
<213>  Gallus gallus domesticus

<400>  15

Phe Arg Thr Leu Leu Leu Asp Glu Glu Arg Gly Arg Leu Leu Val Gly 
1               5                   10                  15      


Ala Lys Asp His Ile Phe Leu Leu Asn Leu Val Asp Leu Asn Lys Asn 
            20                  25                  30          


Val Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu Lys Met Glu Leu Cys 
        35                  40                  45              


Lys Leu Ala Gly Lys Asp Ala His Thr Asp Cys Ala Asn Phe Ile Arg 
    50                  55                  60                  


Val Leu Gln Pro Tyr Asn Arg Thr His Val Tyr Val Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Phe His Pro Leu Cys Gly Tyr Ile Glu Leu Gly Thr His Lys Glu 
                85                  90                  95      


Glu Thr Ile Phe Arg Leu Asp Thr Gln Asn Leu Glu Ser Gly Arg Leu 
            100                 105                 110         


Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala Ser Val Met Ala Asp 
        115                 120                 125             


Glu Tyr Leu Tyr Ala Gly Thr Ala Ser Asp Phe Leu Gly Lys Asp Thr 
    130                 135                 140                 


Ala Leu Thr Arg Ser Leu Gly Pro Ser His Asp His His Tyr Ile Arg 
145                 150                 155                 160 


Thr Asp Ile Ser Glu His Tyr Trp Leu Thr Gly Ala Lys Phe Ile Ala 
                165                 170                 175     


Thr Phe Pro Ile Pro Asp Thr Tyr Asn Pro Asp Asp Asp Lys Ile Tyr 
            180                 185                 190         


Phe Phe Phe Arg Glu Ile Ser Gln Asp Ser Ser Thr Ser Asp Lys Thr 
        195                 200                 205             


Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn Asp Met Gly Gly Gln 
    210                 215                 220                 


Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val 
225                 230                 235                 240 


Cys Ser Ile Pro Gly Pro Glu Gly Ala Asp Thr His Phe Asp Glu Leu 
                245                 250                 255     


Gln Asp Ile Phe Leu Leu Ser Thr Arg Asp Glu Arg Asn Pro Leu Val 
            260                 265                 270         


Tyr Gly Val Phe Thr Thr Thr Ser Ser Val Phe Lys Gly Ser Ala Val 
        275                 280                 285             


Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val Phe Asn Gly Pro Tyr 
    290                 295                 300                 


Ala His Lys Glu Ser Ala Asp His Arg Trp Val Gln Tyr Glu Gly Arg 
305                 310                 315                 320 


Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Tyr Asp Pro 
                325                 330                 335     


Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Glu Val Ile Ser Phe Ile 
            340                 345                 350         


Lys Arg His Pro Leu Met Tyr Lys Ser Val Tyr Pro Leu Thr Gly Gly 
        355                 360                 365             


Pro Val Phe Thr Arg Ile Asn Val Asp Tyr Arg Leu Thr Gln Ile Val 
    370                 375                 380                 


Val Asp His Val Met Ala Glu Asp Gly Gln Tyr Asp Val Ile Phe Leu 
385                 390                 395                 400 


Gly Thr Asp Ile Gly Thr Val Leu Lys Ala Val Ser Ile Thr Lys Glu 
                405                 410                 415     


Lys Trp Thr Lys Glu Glu Val Val Leu Glu Glu Leu Gln Ile Phe Lys 
            420                 425                 430         


His Pro Ser Phe Ile Ser Thr Met Glu Ile Ser Gln Lys Gln 
        435                 440                 445     


<210>  16
<211>  446
<212>  PRT
<213>  Danio rerio

<400>  16

Phe Gln Thr Val Leu Leu Asp Glu Glu Arg Ser Arg Leu Leu Leu Gly 
1               5                   10                  15      


Ala Lys Asp His Val Tyr Leu Leu Asp Pro Asp Asn Ile Asn Lys His 
            20                  25                  30          


Pro Lys Lys Leu Ser Trp Pro Ala Ser Arg Asp Arg Val Glu Met Cys 
        35                  40                  45              


Ile Leu Ala Gly Lys Asn Pro Leu Thr Glu Cys Ala Asn Phe Ile Arg 
    50                  55                  60                  


Val Leu His Ser Tyr Asn Arg Thr His Val Tyr Ala Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Phe His Pro Thr Cys Ala Phe Leu Glu Ile Lys Gly His Lys Glu 
                85                  90                  95      


Asp Arg Trp Leu Leu Leu His Ser Asn Thr Met Glu Ser Gly Arg Met 
            100                 105                 110         


Lys Cys Pro Phe Asp Pro Asn Gln Pro Phe Ala Ser Val Leu Thr Asp 
        115                 120                 125             


Gln Tyr Leu Tyr Ala Gly Thr Ala Ser Asp Phe Leu Gly Lys Asp Ser 
    130                 135                 140                 


Thr Phe Thr Arg Ser Leu Gly Pro Pro Pro His Gln Gln Tyr Ile Arg 
145                 150                 155                 160 


Thr Asp Ile Ser Glu Asp Tyr Trp Ile Asn Glu Gly Lys Phe Ile Ser 
                165                 170                 175     


Ala His Pro Ile Ser Asp Thr Tyr Asn Pro Asp Asp Asp Lys Ile Tyr 
            180                 185                 190         


Phe Phe Phe Arg Glu Ala Ser Arg Asp Gly Ser Thr Thr Asp Lys Ser 
        195                 200                 205             


Val Leu Ser Arg Val Ala Arg Ile Cys Arg Asn Asp Val Gly Gly Leu 
    210                 215                 220                 


Arg Ser Leu Thr Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val 
225                 230                 235                 240 


Cys Ser Ile Pro Gly Pro Asp Gly Val Asp Thr His Phe Asp Glu Leu 
                245                 250                 255     


Gln Asp Ile Phe Leu Leu Pro Ser Arg Asp Glu Lys Asn Pro Met Val 
            260                 265                 270         


Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe Lys Gly Ser Ala Val 
        275                 280                 285             


Cys Val Tyr Thr Met Glu Asp Ile Arg Ala Ala Phe Asn Gly Pro Tyr 
    290                 295                 300                 


Ala His Lys Glu Gly Pro Asp His Arg Trp Val Glu Tyr Glu Gly Arg 
305                 310                 315                 320 


Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Arg Thr Tyr Asp Pro 
                325                 330                 335     


His Ile Lys Thr Thr Lys Asp Phe Pro Asp Glu Val Ile Ser Phe Ile 
            340                 345                 350         


Arg Leu His Pro Leu Met Tyr Gln Ser Val His Pro Met Thr Gly Arg 
        355                 360                 365             


Pro Ile Phe Thr Arg Ile Asn Thr Glu Tyr Arg Leu Thr Gln Ile Ile 
    370                 375                 380                 


Val Asp Arg Val Ala Ala Glu Asp Gly Gln Tyr Ala Val Met Phe Leu 
385                 390                 395                 400 


Gly Thr Asp Met Gly Ser Val Leu Lys Val Val Ser Ile Thr Gln Glu 
                405                 410                 415     


Asn Trp Ser Ser Glu Glu Ile Ile Leu Glu Glu Leu Gln Val Phe Lys 
            420                 425                 430         


Asn Pro Ser Pro Ile Leu Asn Met Glu Val Ser Ser Lys Gln 
        435                 440                 445     


<210>  17
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Gln Ala Leu Leu Val Asp Glu Glu Arg Gly Arg Leu Phe Val Gly 
1               5                   10                  15      


Ala Glu Asn His Val Ala Ser Leu Asn Leu Asp Asn Ile Ser Lys Arg 
            20                  25                  30          


Ala Lys Lys Leu Ala Trp Pro Ala Pro Val Glu Trp Arg Glu Glu Cys 
        35                  40                  45              


Asn Trp Ala Gly Lys Asp Ile Gly Thr Glu Cys Met Asn Phe Val Lys 
    50                  55                  60                  


Leu Leu His Ala Tyr Asn Arg Thr His Leu Leu Ala Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Phe His Pro Thr Cys Ala Phe Val Glu Val Gly His Arg Ala Glu 
                85                  90                  95      


Glu Pro Val Leu Arg Leu Asp Pro Gly Arg Ile Glu Asp Gly Lys Gly 
            100                 105                 110         


Lys Ser Pro Tyr Asp Pro Arg His Arg Ala Ala Ser Val Leu Val Gly 
        115                 120                 125             


Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp Leu Met Gly Arg Asp Phe 
    130                 135                 140                 


Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro Ser Leu Arg Thr Glu Pro 
145                 150                 155                 160 


His Asp Ser Arg Trp Leu Asn Glu Pro Lys Phe Val Lys Val Phe Trp 
                165                 170                 175     


Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp Lys Ile Tyr Phe Phe Phe 
            180                 185                 190         


Arg Glu Thr Ala Val Glu Ala Ala Pro Ala Leu Gly Arg Leu Ser Val 
        195                 200                 205             


Ser Arg Val Gly Gln Ile Cys Arg Asn Asp Val Gly Gly Gln Arg Ser 
    210                 215                 220                 


Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Val Cys Ser 
225                 230                 235                 240 


Val Pro Gly Val Glu Gly Asp Thr His Phe Asp Gln Leu Gln Asp Val 
                245                 250                 255     


Phe Leu Leu Ser Ser Arg Asp His Arg Thr Pro Leu Leu Tyr Ala Val 
            260                 265                 270         


Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly Ser Ala Val Cys Val Tyr 
        275                 280                 285             


Ser Met Asn Asp Val Arg Arg Ala Phe Leu Gly Pro Phe Ala His Lys 
    290                 295                 300                 


Glu Gly Pro Met His Gln Trp Val Ser Tyr Gln Gly Arg Val Pro Tyr 
305                 310                 315                 320 


Pro Arg Pro Gly Met Cys Pro Ser Lys Thr Phe Gly Thr Phe Ser Ser 
                325                 330                 335     


Thr Lys Asp Phe Pro Asp Asp Val Ile Gln Phe Ala Arg Asn His Pro 
            340                 345                 350         


Leu Met Tyr Asn Ser Val Leu Pro Thr Gly Gly Arg Pro Leu Phe Leu 
        355                 360                 365             


Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln Ile Ala Ala Asp Arg Val 
    370                 375                 380                 


Ala Ala Ala Asp Gly His Tyr Asp Val Leu Phe Ile Gly Thr Asp Val 
385                 390                 395                 400 


Gly Thr Val Leu Lys Val Ile Ser Val Pro Lys Gly Ser Arg Pro Ser 
                405                 410                 415     


Ala Glu Gly Leu Leu Leu Glu Glu Leu His Val Phe Glu Asp Ser Ala 
            420                 425                 430         


Ala Val Thr Ser Met Gln Ile Ser Ser Lys Arg 
        435                 440             


<210>  18
<211>  443
<212>  PRT
<213>  Danio rerio

<400>  18

Tyr Asp Thr Phe Leu Met Asp Gly Glu Arg Gly Arg Leu Leu Val Gly 
1               5                   10                  15      


Ala Glu Asp His Val Phe Ser Phe Asp Leu Val Asn Ile Asn Arg Asp 
            20                  25                  30          


Val Lys Gln Ile Ala Trp Pro Ala Thr Pro Ser Lys Arg Asp Glu Cys 
        35                  40                  45              


Lys Trp Ala Gly Lys Asp Leu Arg Lys Asp Cys Ser Asn Phe Val Arg 
    50                  55                  60                  


Val Leu Gln Ser Tyr Asn Gln Thr His Ile Tyr Ile Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Phe His Pro Ile Cys Ser Phe Leu Glu Met Gly Lys Arg Ala Glu 
                85                  90                  95      


Asp Asn Ile Phe Arg Leu Asp Ala Asn Tyr Phe Glu Asn Gly Arg Gly 
            100                 105                 110         


Lys Ser Pro Tyr Asp Pro Lys Met Gln Ser Ser Ser Leu Leu Leu Asp 
        115                 120                 125             


Gly Glu Leu Tyr Ser Gly Thr Ser Ala Asp Phe Met Gly Arg Asp Phe 
    130                 135                 140                 


Ala Ile Phe Arg Thr Leu Gly Ser His His Pro Ile Arg Thr Glu Gln 
145                 150                 155                 160 


His Asp Ser Arg Trp Leu Asn Glu Pro Arg Phe Leu Gly Ile His Leu 
                165                 170                 175     


Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Ile Phe Leu Phe Phe 
            180                 185                 190         


Lys Glu Asn Ala Met Asp Gly Glu His Thr Gly Lys Ala Thr Ile Ser 
        195                 200                 205             


Arg Ile Gly Gln Leu Cys Lys Asn Asp Met Gly Gly His Arg Ser Leu 
    210                 215                 220                 


Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Lys Leu Thr Cys Ser Val 
225                 230                 235                 240 


Pro Gly Leu Asn Gly Ile Asp Thr His Phe Asp Glu Leu Gln Asp Val 
                245                 250                 255     


Phe Leu Met Ser Ala Lys Asp Pro Lys Asn Pro Val Ile Tyr Ala Val 
            260                 265                 270         


Phe Thr Thr Ser Ser Asn Ile Phe Arg Gly Ser Ala Ile Cys Met Tyr 
        275                 280                 285             


Ser Met Ala Asp Ile Arg Arg Val Phe Leu Gly Pro Tyr Ala His Arg 
    290                 295                 300                 


Asp Gly Pro Asn Tyr Gln Trp Val Pro Phe Gln Gly Arg Val Pro Tyr 
305                 310                 315                 320 


Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly Phe Asp Ser 
                325                 330                 335     


Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg Leu His Pro 
            340                 345                 350         


Ala Met Tyr Asn Pro Val Gln Pro Met Gly Gly Lys Pro Ile Val Val 
        355                 360                 365             


Arg Thr Asn Val Glu Tyr Gln Phe Thr Gln Leu Val Val Asp Arg Val 
    370                 375                 380                 


Glu Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly Thr Asp Leu 
385                 390                 395                 400 


Gly Thr Val Leu Lys Val Val Thr Ile Pro Arg Glu Ser Trp His Asp 
                405                 410                 415     


Leu Glu Glu Val Val Leu Glu Glu Met Thr Val Phe Arg Glu Pro Thr 
            420                 425                 430         


Pro Ile Thr Ala Met Glu Leu Ser Thr Lys Gln 
        435                 440             


<210>  19
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Arg Ile Leu Leu Lys Asp Glu Asp His Asp Arg Met Tyr Val Gly 
1               5                   10                  15      


Ser Lys Asp Tyr Val Leu Ser Leu Asp Leu His Asp Ile Asn Arg Glu 
            20                  25                  30          


Pro Leu Ile Ile His Trp Ala Ala Ser Pro Gln Arg Ile Glu Glu Cys 
        35                  40                  45              


Val Leu Ser Gly Lys Asp Val Asn Gly Glu Cys Gly Asn Phe Val Arg 
    50                  55                  60                  


Leu Ile Gln Pro Trp Asn Arg Thr His Leu Tyr Val Cys Gly Thr Gly 
65                  70                  75                  80  


Ala Tyr Asn Pro Met Cys Thr Tyr Val Asn Arg Gly Arg Arg Ala Gln 
                85                  90                  95      


Ala Thr Pro Trp Thr Gln Thr Gln Ala Val Arg Gly Arg Gly Ser Arg 
            100                 105                 110         


Ala Thr Asp Gly Ala Leu Arg Pro Met Pro Thr Ala Pro Arg Gln Asp 
        115                 120                 125             


Tyr Ile Phe Tyr Leu Glu Pro Glu Arg Leu Glu Ser Gly Lys Gly Lys 
    130                 135                 140                 


Cys Pro Tyr Asp Pro Lys Leu Asp Thr Ala Ser Ala Leu Ile Asn Glu 
145                 150                 155                 160 


Glu Leu Tyr Ala Gly Val Tyr Ile Asp Phe Met Gly Thr Asp Ala Ala 
                165                 170                 175     


Ile Phe Arg Thr Leu Gly Lys Gln Thr Ala Met Arg Thr Asp Gln Tyr 
            180                 185                 190         


Asn Ser Arg Trp Leu Asn Asp Pro Ser Phe Ile His Ala Glu Leu Ile 
        195                 200                 205             


Pro Asp Ser Ala Glu Arg Asn Asp Asp Lys Leu Tyr Phe Phe Phe Arg 
    210                 215                 220                 


Glu Arg Ser Ala Glu Ala Pro Gln Ser Pro Ala Val Tyr Ala Arg Ile 
225                 230                 235                 240 


Gly Arg Ile Cys Leu Asn Asp Asp Gly Gly His Cys Cys Leu Val Asn 
                245                 250                 255     


Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Pro Gly 
            260                 265                 270         


Glu Asp Gly Ile Glu Thr His Phe Asp Glu Leu Gln Asp Val Phe Val 
        275                 280                 285             


Gln Gln Thr Gln Asp Val Arg Asn Pro Val Ile Tyr Ala Val Phe Thr 
    290                 295                 300                 


Ser Ser Gly Ser Val Phe Arg Gly Ser Ala Val Cys Val Tyr Ser Met 
305                 310                 315                 320 


Ala Asp Ile Arg Met Val Phe Asn Gly Pro Phe Ala His Lys Glu Gly 
                325                 330                 335     


Pro Asn Tyr Gln Trp Met Pro Phe Ser Gly Lys Met Pro Tyr Pro Arg 
            340                 345                 350         


Pro Gly Thr Cys Pro Gly Gly Thr Phe Thr Pro Ser Met Lys Ser Thr 
        355                 360                 365             


Lys Asp Tyr Pro Asp Glu Val Ile Asn Phe Met Arg Ser His Pro Leu 
    370                 375                 380                 


Met Tyr Gln Ala Val Tyr Pro Leu Gln Arg Arg Pro Leu Val Val Arg 
385                 390                 395                 400 


Thr Gly Ala Pro Tyr Arg Leu Thr Thr Ile Ala Val Asp Gln Val Asp 
                405                 410                 415     


Ala Gly Asp Gly Arg Tyr Glu Val Leu Phe Leu Gly Thr Asp Arg Gly 
            420                 425                 430         


Thr Val Gln Lys Val Ile Val Leu Pro Lys Asp Asp Gln Glu Met Glu 
        435                 440                 445             


Glu Leu Met Leu Glu Glu Val Glu Val Phe Lys Asp Pro Ala Pro Val 
    450                 455                 460                 


Lys Thr Met Thr Ile Ser Ser Lys Arg 
465                 470             


<210>  20
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Leu Thr Leu Thr Leu Thr Glu Pro Thr Gly Leu Leu Tyr Val Gly 
1               5                   10                  15      


Ala Arg Glu Ala Leu Phe Ala Phe Ser Met Glu Ala Leu Glu Leu Gln 
            20                  25                  30          


Gly Ala Ile Ser Trp Glu Ala Pro Val Glu Lys Lys Thr Glu Cys Ile 
        35                  40                  45              


Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe Asn Phe Ile Arg Phe 
    50                  55                  60                  


Leu Gln Pro Tyr Asn Ala Ser His Leu Tyr Val Cys Gly Thr Tyr Ala 
65                  70                  75                  80  


Phe Gln Pro Lys Cys Thr Tyr Val Asn Met Leu Thr Phe Thr Arg Phe 
                85                  90                  95      


Leu Gln Pro Tyr Asn Ala Ser His Leu Tyr Val Cys Gly Thr Tyr Ala 
            100                 105                 110         


Phe Gln Pro Lys Cys Thr Tyr Val Asn Met Leu Thr Phe Thr Leu Glu 
        115                 120                 125             


His Gly Glu Phe Glu Asp Gly Lys Gly Lys Cys Pro Tyr Asp Pro Ala 
    130                 135                 140                 


Lys Gly His Ala Gly Leu Leu Val Asp Gly Glu Leu Tyr Ser Ala Thr 
145                 150                 155                 160 


Leu Asn Asn Phe Leu Gly Thr Glu Pro Ile Ile Leu Arg Asn Met Gly 
                165                 170                 175     


Pro His His Ser Met Lys Thr Glu Tyr Leu Ala Phe Trp Leu Asn Glu 
            180                 185                 190         


Pro His Phe Val Gly Ser Ala Tyr Val Pro Glu Ser Val Gly Ser Phe 
        195                 200                 205             


Thr Gly Asp Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Arg Ala Val 
    210                 215                 220                 


Glu Ser Asp Cys Tyr Ala Glu Gln Val Val Ala Arg Val Ala Arg Val 
225                 230                 235                 240 


Cys Lys Gly Asp Met Gly Gly Ala Arg Thr Leu Gln Arg Lys Trp Thr 
                245                 250                 255     


Thr Phe Leu Lys Ala Arg Leu Ala Cys Ser Ala Pro Asn Trp Gln Leu 
            260                 265                 270         


Tyr Phe Asn Gln Leu Gln Ala Met His Thr Leu Gln Asp Thr Ser Trp 
        275                 280                 285             


His Asn Thr Thr Phe Phe Gly Val Phe Gln Ala Gln Trp Gly Asp Met 
    290                 295                 300                 


Tyr Leu Ser Ala Ile Cys Glu Tyr Gln Leu Glu Glu Ile Gln Arg Val 
305                 310                 315                 320 


Phe Glu Gly Pro Tyr Lys Glu Tyr His Glu Glu Ala Gln Lys Trp Asp 
                325                 330                 335     


Arg Tyr Thr Asp Pro Val Pro Ser Pro Arg Pro Gly Ser Cys Ile Asn 
            340                 345                 350         


Asn Trp His Arg Arg His Gly Tyr Thr Ser Ser Leu Glu Leu Pro Asp 
        355                 360                 365             


Asn Ile Leu Asn Phe Val Lys Lys His Pro Leu Met Glu Glu Gln Val 
    370                 375                 380                 


Gly Pro Arg Trp Ser Arg Pro Leu Leu Val Lys Lys Gly Thr Asn Phe 
385                 390                 395                 400 


Thr His Leu Val Ala Asp Arg Val Thr Gly Leu Asp Gly Ala Thr Tyr 
                405                 410                 415     


Thr Val Leu Phe Ile Gly Thr Gly Asp Gly Trp Leu Leu Lys Ala Val 
            420                 425                 430         


Ser Leu Gly Pro Trp Val His Leu Ile Glu Glu Leu Gln Leu Phe Asp 
        435                 440                 445             


Gln Glu Pro Met Arg Ser Leu Val Leu Ser Gln Ser Lys 
    450                 455                 460     


<210>  21
<211>  432
<212>  PRT
<213>  Mus musculus

<400>  21

Tyr Ser Ala Leu Leu Val Asp Pro Ala Ser His Thr Leu Tyr Val Gly 
1               5                   10                  15      


Ala Arg Asp Ser Ile Phe Ala Leu Thr Leu Pro Phe Ser Gly Glu Lys 
            20                  25                  30          


Pro Arg Arg Ile Asp Trp Met Val Pro Glu Thr His Arg Gln Asn Cys 
        35                  40                  45              


Arg Lys Lys Gly Lys Lys Glu Asp Glu Cys His Asn Phe Ile Gln Ile 
    50                  55                  60                  


Leu Ala Ile Ala Asn Ala Ser His Leu Leu Thr Cys Gly Thr Phe Ala 
65                  70                  75                  80  


Phe Asp Pro Lys Cys Gly Val Ile Asp Val Ser Ser Phe Gln Gln Val 
                85                  90                  95      


Glu Arg Leu Glu Ser Gly Arg Gly Lys Cys Pro Phe Glu Pro Ala Gln 
            100                 105                 110         


Arg Ser Ala Ala Val Met Ala Gly Gly Val Leu Tyr Thr Ala Thr Val 
        115                 120                 125             


Lys Asn Phe Leu Gly Thr Glu Pro Ile Ile Ser Arg Ala Val Gly Arg 
    130                 135                 140                 


Ala Glu Asp Trp Ile Arg Thr Glu Thr Leu Ser Ser Trp Leu Asn Ala 
145                 150                 155                 160 


Pro Ala Phe Val Ala Ala Met Val Leu Ser Pro Ala Glu Trp Gly Asp 
                165                 170                 175     


Glu Asp Gly Asp Asp Glu Ile Phe Phe Phe Phe Thr Glu Thr Ser Arg 
            180                 185                 190         


Val Leu Asp Ser Tyr Glu Arg Ile Lys Val Pro Arg Val Ala Arg Val 
        195                 200                 205             


Cys Ala Gly Asp Leu Gly Gly Arg Lys Thr Leu Gln Gln Arg Trp Thr 
    210                 215                 220                 


Thr Phe Leu Lys Ala Asp Leu Leu Cys Pro Gly Pro Glu His Gly Arg 
225                 230                 235                 240 


Ala Ser Gly Val Leu Gln Asp Met Thr Glu Leu Arg Pro Gln Pro Gly 
                245                 250                 255     


Ala Gly Thr Pro Leu Phe Tyr Gly Ile Phe Ser Ser Gln Trp Glu Gly 
            260                 265                 270         


Ala Ala Ile Ser Ala Val Cys Ala Phe Arg Pro Gln Asp Ile Arg Ala 
        275                 280                 285             


Val Leu Asn Gly Pro Phe Arg Glu Leu Lys His Asp Cys Asn Arg Gly 
    290                 295                 300                 


Leu Pro Val Met Asp Asn Glu Val Pro Gln Pro Arg Pro Gly Glu Cys 
305                 310                 315                 320 


Ile Thr Asn Asn Met Lys Phe Gln Gln Phe Gly Ser Ser Leu Ser Leu 
                325                 330                 335     


Pro Asp Arg Val Leu Thr Phe Ile Arg Asp His Pro Leu Met Asp Arg 
            340                 345                 350         


Pro Val Phe Pro Ala Asp Gly Arg Pro Leu Leu Val Thr Thr Asp Thr 
        355                 360                 365             


Ala Tyr Leu Arg Val Val Ala His Arg Val Thr Ser Leu Ser Gly Lys 
    370                 375                 380                 


Glu Tyr Asp Val Leu Tyr Leu Gly Thr Glu Asp Gly His Leu His Arg 
385                 390                 395                 400 


Ala Val Arg Ile Gly Ala Gln Leu Ser Val Leu Glu Asp Leu Ala Leu 
                405                 410                 415     


Phe Pro Glu Pro Gln Pro Val Glu Ser Met Lys Leu Tyr His Asp Trp 
            420                 425                 430         


<210>  22
<211>  433
<212>  PRT
<213>  Mus musculus

<400>  22

Tyr Ser Ala Leu Leu Met Ser Glu Asp Lys Asp Thr Leu Tyr Val Gly 
1               5                   10                  15      


Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu Lys 
            20                  25                  30          


Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ser Lys Cys 
        35                  40                  45              


Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile Arg 
    50                  55                  60                  


Val Leu Gln Pro Leu Ser Ser Thr Ser Leu Tyr Val Cys Gly Thr Asn 
65                  70                  75                  80  


Ala Phe Gln Pro Thr Cys Asp His Leu Asn Leu Thr Ser Phe Lys Phe 
                85                  90                  95      


Leu Gly Lys Ser Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro Ala 
            100                 105                 110         


His Ser Tyr Thr Ser Val Met Val Gly Gly Glu Leu Tyr Ser Gly Thr 
        115                 120                 125             


Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser Ser 
    130                 135                 140                 


His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu Pro 
145                 150                 155                 160 


Ser Phe Val Phe Ala Asp Val Ile Gln Lys Ser Pro Asp Gly Pro Glu 
                165                 170                 175     


Gly Glu Asp Asp Lys Val Tyr Phe Phe Phe Thr Glu Val Ser Val Glu 
            180                 185                 190         


Tyr Glu Phe Val Phe Lys Leu Met Ile Pro Arg Val Ala Arg Val Cys 
        195                 200                 205             


Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr Ser 
    210                 215                 220                 


Phe Leu Lys Ala Arg Leu Ile Cys Ser Lys Pro Asp Ser Gly Leu Val 
225                 230                 235                 240 


Phe Asn Ile Leu Gln Asp Val Phe Val Leu Arg Ala Pro Gly Leu Lys 
                245                 250                 255     


Glu Pro Val Phe Tyr Ala Val Phe Thr Pro Gln Leu Asn Asn Val Gly 
            260                 265                 270         


Leu Ser Ala Val Cys Ala Tyr Thr Leu Ala Thr Val Glu Ala Val Phe 
        275                 280                 285             


Ser Arg Gly Lys Tyr Met Gln Ser Ala Thr Val Glu Gln Ser His Thr 
    290                 295                 300                 


Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Thr Pro Arg Pro Gly Ala 
305                 310                 315                 320 


Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu Asn 
                325                 330                 335     


Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met Asp 
            340                 345                 350         


Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Lys Leu Ile Lys Lys Asp 
        355                 360                 365             


Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp Gly 
    370                 375                 380                 


Thr Phe Tyr Asp Val Met Phe Ile Ser Thr Asp Arg Gly Ala Leu His 
385                 390                 395                 400 


Lys Ala Val Ile Leu Thr Lys Glu Val His Val Ile Glu Glu Thr Gln 
                405                 410                 415     


Leu Phe Arg Asp Phe Glu Pro Val Leu Thr Leu Leu Leu Ser Ser Lys 
            420                 425                 430         


Lys 
    


<210>  23
<211>  431
<212>  PRT
<213>  Danio rerio

<400>  23

Tyr Thr Thr Met Leu Leu Arg Asp Asp Leu Asn Leu Leu Ile Leu Gly 
1               5                   10                  15      


Ala Arg Glu Ala Ile Phe Ala Leu Asp Leu Asp Asp Ile Thr Ile Lys 
            20                  25                  30          


Lys Ala Met Leu Lys Trp Glu Val Thr Arg Asp Gln Gln Asn Asp Cys 
        35                  40                  45              


Ser Asn Lys Gly Lys Asp Ala Thr Asn Asp Cys Lys Asn Tyr Ile Arg 
    50                  55                  60                  


Ile Leu His Lys Lys Asn Asp Gly Arg Met Tyr Val Cys Gly Thr Lys 
65                  70                  75                  80  


Ala Phe Asn Pro Thr Cys Gly Tyr Leu Ser Tyr Ala Asp Gly Lys Leu 
                85                  90                  95      


Thr Leu Glu Ile Leu Gln Glu Asp Thr Lys Gly Lys Cys Pro Phe Asp 
            100                 105                 110         


Pro Phe Gln Arg Tyr Thr Ser Ala Met Val Asp Gly Ala Tyr Tyr Ser 
        115                 120                 125             


Ala Thr Ser Met Asn Phe Arg Gly Ser Glu Pro Val Met Met Arg Ser 
    130                 135                 140                 


Thr Glu Glu Ser Ile Arg Thr Glu Phe Thr Ser Thr Trp Leu Ser Glu 
145                 150                 155                 160 


Pro Asn Phe Ile His Met Ala His Ile Pro Glu Gly Gln Ser Asn Pro 
                165                 170                 175     


Asp Gly Asp Asp Asp Lys Ile Tyr Leu Phe Phe Ser Glu Thr Ala Val 
            180                 185                 190         


Glu Tyr Glu Ser Tyr Thr Lys Val Asp Val Ser Arg Val Ala Arg Val 
        195                 200                 205             


Cys Lys Gly Asp Leu Gly Gly Gln Arg Thr Leu Gln Lys Lys Trp Thr 
    210                 215                 220                 


Ser Phe Leu Lys Ala Arg Leu Asp Cys Gln Val Pro Asn Thr Asn Leu 
225                 230                 235                 240 


Pro Leu Leu Val Gln Asp Val Phe His Leu Cys Pro Asp Asp Trp Thr 
                245                 250                 255     


Thr Cys Val Phe Tyr Ala Val Phe Thr Pro Gln Ser Asp Ser Ser Gln 
            260                 265                 270         


Tyr Ser Ala Val Cys Ser Tyr Lys Ile Glu Asp Ile Lys Thr Val Phe 
        275                 280                 285             


Ser Lys Gly Lys Phe Lys Ala Pro Phe Asn Val Glu Thr Ser Phe Val 
    290                 295                 300                 


Lys Trp Val Met Tyr Ser Gly Glu Leu Pro Asp Pro Arg Pro Gly Ala 
305                 310                 315                 320 


Cys Ile Asp Asn His Ala Arg Glu Lys Gly Ile Thr Lys Ser Leu Glu 
                325                 330                 335     


Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp Lys Pro Leu Met Asp 
            340                 345                 350         


Gln Ala Val Thr Ala Glu Gln Pro Leu Leu Val Lys Arg Gly Ala Ala 
        355                 360                 365             


Phe Thr Arg Ile Val Val Thr Thr Ala Thr Ala Leu Asn Gly Thr Ser 
    370                 375                 380                 


His Gln Val Met Phe Ile Gly Thr Lys Ser Gly Ser Val Leu Lys Ala 
385                 390                 395                 400 


Val Asn Tyr Asn Gly Glu Met Val Ile Met Glu Glu Ile Gln Leu Phe 
                405                 410                 415     


Asp Pro Ser Glu Pro Ile Lys Ile Leu Arg Leu Ser Ser Ser Lys 
            420                 425                 430     


<210>  24
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Ser Thr Leu Leu Leu Glu Glu Ala Ser Ala Arg Leu Leu Val Gly 
1               5                   10                  15      


Ala Arg Gly Ala Leu Phe Ser Leu Ser Ala Asn Asp Ile Gly Asp Gly 
            20                  25                  30          


Ala His Lys Glu Ile His Trp Glu Ala Ser Pro Glu Met Gln Ser Lys 
        35                  40                  45              


Cys His Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe Asn His Val 
    50                  55                  60                  


Arg Phe Leu Gln Arg Leu Asn Ser Thr His Leu Tyr Ala Cys Gly Thr 
65                  70                  75                  80  


His Ala Phe Gln Pro Leu Cys Ala Ala Ile Asp Ala Glu Ala Phe Thr 
                85                  90                  95      


Leu Pro Thr Ser Phe Glu Glu Gly Lys Glu Lys Cys Pro Tyr Asp Pro 
            100                 105                 110         


Ala Arg Gly Phe Thr Gly Leu Ile Ile Asp Gly Gly Leu Tyr Thr Ala 
        115                 120                 125             


Thr Arg Tyr Glu Phe Arg Ser Ile Pro Asp Ile Arg Arg Ser Arg His 
    130                 135                 140                 


Pro His Ser Leu Arg Thr Glu Glu Thr Pro Met His Trp Leu Asn Asp 
145                 150                 155                 160 


Ala Glu Phe Val Phe Ser Val Leu Val Arg Glu Ser Lys Ala Ser Ala 
                165                 170                 175     


Val Gly Asp Asp Asp Lys Val Tyr Tyr Phe Phe Thr Glu Arg Ala Thr 
            180                 185                 190         


Glu Glu Gln Ser Arg Ser Ser His Arg Val Ala Arg Val Ala Arg Val 
        195                 200                 205             


Cys Lys Gly Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Lys Trp Thr 
    210                 215                 220                 


Ser Phe Leu Lys Ala Arg Leu Ile Cys His Ile Pro Leu Tyr Glu Thr 
225                 230                 235                 240 


Leu Arg Gly Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Arg Thr His 
                245                 250                 255     


Phe Tyr Ala Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Leu Glu Ala 
            260                 265                 270         


Ser Ala Ile Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Val Phe Ala 
        275                 280                 285             


Gly Pro Tyr Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gly Arg Tyr 
    290                 295                 300                 


Glu Gly Gly Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Thr Asp Ser 
305                 310                 315                 320 


Leu Arg Ser Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Ser Leu Val 
                325                 330                 335     


Leu Asp Phe Val Lys Leu His Pro Leu Met Ala Arg Pro Val Val Pro 
            340                 345                 350         


Thr Arg Gly Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Tyr Thr His 
        355                 360                 365             


Leu Thr Gly Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Tyr Asp Leu 
    370                 375                 380                 


Leu Phe Leu Gly Thr Ala Asp Gly Trp Ile His Lys Ala Val Val Leu 
385                 390                 395                 400 


Gly Ser Gly Met His Ile Ile Glu Glu Thr Gln Val Phe Arg Glu Ser 
                405                 410                 415     


Gln Ser Val Glu Asn Leu Val Ile Ser Leu Leu Gln 
            420                 425             


<210>  25
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  25

Tyr Thr Ala Leu Leu Leu Ser Arg Asp Gly Arg Thr Leu Tyr Val Gly 
1               5                   10                  15      


Ala Arg Glu Ala Leu Phe Ala Leu Ser Ser Asn Leu Ser Phe Leu Pro 
            20                  25                  30          


Gly Gly Glu Tyr Gln Glu Leu Leu Trp Gly Ala Asp Ala Glu Lys Lys 
        35                  40                  45              


Gln Gln Cys Ser Phe Lys Gly Lys Asp Pro Gln Arg Asp Cys Gln Asn 
    50                  55                  60                  


Tyr Ile Lys Ile Leu Leu Pro Leu Ser Gly Ser His Leu Phe Thr Cys 
65                  70                  75                  80  


Gly Thr Ala Ala Phe Ser Pro Met Cys Thr Tyr Ile Asn Met Glu Asn 
                85                  90                  95      


Phe Thr Leu Ala Arg Asp Glu Lys Gly Asn Val Leu Leu Glu Asp Gly 
            100                 105                 110         


Lys Gly Arg Cys Pro Phe Asp Pro Asn Phe Lys Ser Thr Ala Leu Val 
        115                 120                 125             


Val Asp Gly Glu Leu Tyr Thr Gly Thr Val Ser Ser Phe Gln Gly Asn 
    130                 135                 140                 


Asp Pro Ala Ile Ser Arg Ser Gln Ser Leu Arg Pro Thr Lys Thr Glu 
145                 150                 155                 160 


Ser Ser Leu Asn Trp Leu Gln Asp Pro Ala Phe Val Ala Ser Ala Tyr 
                165                 170                 175     


Ile Pro Glu Ser Leu Gly Ser Leu Gln Gly Asp Asp Asp Lys Ile Tyr 
            180                 185                 190         


Phe Phe Phe Ser Glu Thr Gly Gln Glu Phe Glu Phe Phe Glu Asn Thr 
        195                 200                 205             


Ile Val Ser Arg Ile Ala Arg Ile Cys Lys Gly Asp Glu Gly Gly Glu 
    210                 215                 220                 


Arg Val Leu Gln Gln Arg Trp Thr Ser Phe Leu Lys Ala Gln Leu Leu 
225                 230                 235                 240 


Cys Ser Arg Pro Asp Asp Gly Phe Pro Phe Asn Val Leu Gln Asp Val 
                245                 250                 255     


Phe Thr Leu Ser Pro Ser Pro Gln Asp Trp Arg Asp Thr Leu Phe Tyr 
            260                 265                 270         


Gly Val Phe Thr Ser Gln Trp His Arg Gly Thr Thr Glu Gly Ser Ala 
        275                 280                 285             


Val Cys Val Phe Thr Met Lys Asp Val Gln Arg Val Phe Ser Gly Leu 
    290                 295                 300                 


Tyr Lys Glu Val Asn Arg Glu Thr Gln Gln Trp Tyr Thr Val Thr His 
305                 310                 315                 320 


Pro Val Pro Thr Pro Arg Pro Gly Ala Cys Ile Thr Asn Ser Ala Arg 
                325                 330                 335     


Glu Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro Asp Arg Val Leu Asn 
            340                 345                 350         


Phe Leu Lys Asp His Phe Leu Met Asp Gly Gln Val Arg Ser Arg Met 
        355                 360                 365             


Leu Leu Leu Gln Pro Gln Ala Arg Tyr Gln Arg Val Ala Val His Arg 
    370                 375                 380                 


Val Pro Gly Leu His His Thr Tyr Asp Val Leu Phe Leu Gly Thr Gly 
385                 390                 395                 400 


Asp Gly Arg Leu His Lys Ala Val Ser Val Gly Pro Arg Val His Ile 
                405                 410                 415     


Ile Glu Glu Leu Gln Ile Phe Ser Ser Gly Gln Pro Val Gln Asn Leu 
            420                 425                 430         


Leu Leu Asp Thr His Arg 
        435             


<210>  26
<211>  415
<212>  PRT
<213>  Mus musculus

<400>  26

Phe Asp Thr Leu Leu Leu Ser Asp Asp Gly Asn Thr Leu Tyr Val Gly 
1               5                   10                  15      


Ala Arg Glu Thr Val Leu Ala Leu Asn Ile Gln Asn Pro Gly Ile Pro 
            20                  25                  30          


Arg Leu Lys Asn Met Ile Pro Trp Pro Ala Ser Glu Arg Lys Lys Thr 
        35                  40                  45              


Glu Cys Ala Phe Lys Lys Lys Ser Asn Glu Thr Gln Cys Phe Asn Phe 
    50                  55                  60                  


Ile Arg Val Leu Val Ser Tyr Asn Ala Thr His Leu Tyr Ala Cys Gly 
65                  70                  75                  80  


Thr Phe Ala Phe Ser Pro Ala Cys Thr Phe Ile Glu Leu Gln Asp Ser 
                85                  90                  95      


Leu Leu Leu Pro Ile Leu Ile Asp Lys Val Met Asp Gly Lys Gly Gln 
            100                 105                 110         


Ser Pro Leu Thr Leu Phe Thr Ser Thr Gln Ala Val Leu Val Asp Gly 
        115                 120                 125             


Met Leu Tyr Ser Gly Thr Met Asn Asn Phe Leu Gly Ser Glu Pro Ile 
    130                 135                 140                 


Leu Met Arg Thr Leu Gly Ser His Pro Val Leu Lys Thr Asp Ile Phe 
145                 150                 155                 160 


Leu Arg Trp Leu His Ala Asp Ala Ser Phe Val Ala Ala Ile Pro Ser 
                165                 170                 175     


Thr Gln Val Val Tyr Phe Phe Phe Glu Glu Thr Ala Ser Glu Phe Asp 
            180                 185                 190         


Phe Phe Glu Glu Leu Tyr Ile Ser Arg Val Ala Gln Val Cys Lys Asn 
        195                 200                 205             


Asp Val Gly Gly Glu Lys Leu Leu Gln Lys Lys Trp Thr Thr Phe Leu 
    210                 215                 220                 


Lys Ala Gln Leu Leu Cys Ala Gln Pro Gly Gln Leu Pro Phe Asn Ile 
225                 230                 235                 240 


Ile Arg His Ala Val Leu Leu Pro Ala Asp Ser Pro Ser Val Ser Arg 
                245                 250                 255     


Ile Tyr Ala Val Phe Thr Ser Gln Trp Gln Val Gly Gly Thr Arg Ser 
            260                 265                 270         


Ser Ala Val Cys Ala Phe Ser Leu Thr Asp Ile Glu Arg Val Phe Lys 
        275                 280                 285             


Gly Lys Tyr Lys Glu Leu Asn Lys Glu Thr Ser Arg Trp Thr Thr Tyr 
    290                 295                 300                 


Arg Gly Ser Glu Val Ser Pro Arg Pro Gly Ser Cys Ser Met Gly Pro 
305                 310                 315                 320 


Ser Ser Asp Lys Ala Leu Thr Phe Met Lys Asp His Phe Leu Met Asp 
                325                 330                 335     


Glu His Val Val Gly Thr Pro Leu Leu Val Lys Ser Gly Val Glu Tyr 
            340                 345                 350         


Thr Arg Leu Ala Val Glu Ser Ala Arg Gly Leu Asp Gly Ser Ser His 
        355                 360                 365             


Val Val Met Tyr Leu Gly Thr Ser Thr Gly Pro Leu His Lys Ala Val 
    370                 375                 380                 


Val Pro Gln Asp Ser Ser Ala Tyr Leu Val Glu Glu Ile Gln Leu Ser 
385                 390                 395                 400 


Pro Asp Ser Glu Pro Val Arg Asn Leu Gln Leu Ala Pro Ala Gln 
                405                 410                 415 


<210>  27
<211>  439
<212>  PRT
<213>  Mus musculus

<400>  27

Ile Gln Asn Val Val Leu Tyr Lys His His Val Tyr Ile Gly Ala Val 
1               5                   10                  15      


Asn Lys Ile Tyr Val Leu Asn Glu Thr Leu Gln Asn Ile Ser Val Tyr 
            20                  25                  30          


Lys Thr Gly Pro Ile Leu Glu Ser Pro Gly Cys Ala Pro Cys Glu Asp 
        35                  40                  45              


Cys Lys Asp Lys Ala Asn Leu Ser Asn Ser Val Trp Lys Asp Asn Val 
    50                  55                  60                  


Asn Met Ala Leu Leu Leu Glu Thr Tyr Tyr Asp Asp Gln Leu Ile Ser 
65                  70                  75                  80  


Cys Gly Ser Val Ser Gly Gly Val Cys His Arg His Ile Ile Pro Pro 
                85                  90                  95      


Asp Asn Pro Ala Asp Ile Glu Ser Glu Val His Cys Met Tyr Ser Pro 
            100                 105                 110         


Gln Val Asp Gly Glu Ala Asp Asn Cys Pro Asp Cys Val Val Ser Thr 
        115                 120                 125             


Leu Gly Thr Lys Val Leu Val Thr Glu Lys Asp Arg Phe Val Asn Phe 
    130                 135                 140                 


Phe Val Gly Asn Thr Met Thr Ser Ala Phe Gln Pro Pro His Val Leu 
145                 150                 155                 160 


His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln Asp Gly Phe Glu 
                165                 170                 175     


Phe Leu Thr Asp Gln Ser Tyr Ile Asp Ile Leu Pro Gln Phe Arg Asp 
            180                 185                 190         


Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu His Asp His Phe Val 
        195                 200                 205             


Tyr Phe Leu Thr Val Gln Arg Glu Ser Leu Asp Ser Gln Thr Phe His 
    210                 215                 220                 


Thr Arg Ile Ile Arg Phe Cys Thr Leu Asp Ser Glu Met Arg Ser Tyr 
225                 230                 235                 240 


Met Glu Met Pro Leu Glu Cys Ile Phe Thr Glu Ile Arg Lys Glu Val 
                245                 250                 255     


Phe Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro Gly Ala Ala Leu 
            260                 265                 270         


Ala His Glu Met Gly Leu Gly Leu Ile Asp Asp Ile Leu Tyr Gly Val 
        275                 280                 285             


Phe Ala Gln Thr Asn Gln Ile Pro Gln Glu Pro Thr Asn Arg Ser Ala 
    290                 295                 300                 


Val Cys Ala Val Ser Val Arg Thr Ile Asn Glu Phe Phe Asn Lys Ile 
305                 310                 315                 320 


Val Asp Lys Gln Asn Met Lys Cys Leu Gln His Phe Tyr Gly Lys Asp 
                325                 330                 335     


Ser Lys Tyr Cys Leu Asn Arg Ala Phe Ser Arg Asn Ala Ser Tyr Cys 
            340                 345                 350         


Arg Ala Gln Asp Asp Glu Tyr Arg Leu Glu Val Thr Thr Pro Leu Gln 
        355                 360                 365             


Arg Val Asp Leu Phe Met Gly Gln Phe Asn Asn Ile Leu Leu Thr Ser 
    370                 375                 380                 


Ile Ser Val Phe Thr Lys Gly Asn Leu Thr Ile Ala Asn Leu Gly Thr 
385                 390                 395                 400 


Ser Glu Gly Arg Phe Met Gln Ile Val Val Ser Arg Ser Glu Pro Thr 
                405                 410                 415     


Ala Pro His Val Ser Phe Gln Leu Asp Ser His Ala Val Ser Pro Gln 
            420                 425                 430         


Val Val Val Glu Gln Ser Ala 
        435                 


<210>  28
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  28

Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu Gly Ala Thr 
1               5                   10                  15      


Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys Val Ala Glu 
            20                  25                  30          


Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe Pro Cys Gln 
        35                  40                  45              


Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp Lys Asp Asn 
    50                  55                  60                  


Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His Val Phe Pro 
                85                  90                  95      


His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys Ile Phe Ser 
            100                 105                 110         


Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val Val Ser Ala 
        115                 120                 125             


Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe Ile Asn Phe 
    130                 135                 140                 


Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp His Pro Leu 
145                 150                 155                 160 


His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp Gly Phe Met 
                165                 170                 175     


Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu Phe Arg Asp 
            180                 185                 190         


Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn Asn Phe Ile 
        195                 200                 205             


Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln Thr Phe His 
    210                 215                 220                 


Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu His Ser Tyr 
225                 230                 235                 240 


Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Thr Lys Lys Glu Val 
                245                 250                 255     


Phe Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro Gly Ala Gln Leu 
            260                 265                 270         


Ala Arg Gln Ile Gly Ala Ser Leu Asn Asp Asp Ile Leu Phe Gly Val 
        275                 280                 285             


Phe Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser Ala 
    290                 295                 300                 


Met Cys Ala Phe Pro Ile Lys Tyr Val Asn Asp Phe Phe Asn Lys Ile 
305                 310                 315                 320 


Val Asn Lys Asn Asn Val Arg Cys Leu Gln His Phe Tyr Gly Pro Asn 
                325                 330                 335     


His Glu His Cys Phe Asn Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys 
            340                 345                 350         


Glu Ala Arg Arg Asp Glu Tyr Arg Thr Glu Phe Thr Thr Ala Leu Gln 
        355                 360                 365             


Arg Val Asp Leu Phe Met Gly Gln Phe Ser Glu Val Leu Leu Thr Ser 
    370                 375                 380                 


Ile Ser Thr Phe Ile Lys Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr 
385                 390                 395                 400 


Ser Glu Gly Arg Phe Met Gln Val Val Val Ser Arg Ser Gly Pro Ser 
                405                 410                 415     


Thr Pro His Val Asn Phe Leu Leu Asp Ser His Pro Val Ser Pro Glu 
            420                 425                 430         


Val Ile Val Glu His Thr Leu 
        435                 


<210>  29
<211>  439
<212>  PRT
<213>  Apteryx australis mantelli

<400>  29

Ile Gln Ser Ile Ile Met Phe Lys Gly Tyr Val Tyr Val Gly Ala Val 
1               5                   10                  15      


Asn Lys Ile Tyr Val Leu Asn Glu Asn Leu Thr Lys Ile Ser Glu Tyr 
            20                  25                  30          


Lys Thr Gly Pro Leu Leu Lys His Ser Asp Cys Leu Pro Cys Lys Asn 
        35                  40                  45              


Cys Thr Asp Asn Leu Leu Ser Pro Asn Gly Thr Trp Lys Asp Ser Val 
    50                  55                  60                  


Asn Met Ala Leu Phe Val Gln Asp Phe Tyr Asp Asp Gln Leu Ile Ser 
65                  70                  75                  80  


Cys Gly Asn Ile Arg Lys Gly Glu Cys Gln Arg His Thr Leu His Ser 
                85                  90                  95      


Asp Lys Pro Trp Asp Ile Ala Ser Asp Val His Cys Leu Tyr Ser Ser 
            100                 105                 110         


Gln Met Val Glu Asp Lys Asp Ser Cys Pro Asp Cys Ile Val Ser Thr 
        115                 120                 125             


Ala Gly Ser Lys Ile Leu Val Thr Val Gly Asp Arg Phe Val Lys Phe 
    130                 135                 140                 


Phe Val Gly Ser Thr Leu Thr Gly Gln Pro Ser Thr Ile His Ser Val 
145                 150                 155                 160 


Ser Val Arg Arg Leu Lys Glu Thr Gln Asp Gly Phe Glu Tyr Leu Thr 
                165                 170                 175     


Asp Gln Ser Tyr Ile Asp Val Leu Pro His Leu Arg Asp Ile Tyr Pro 
            180                 185                 190         


Ile Arg Tyr Ile Tyr Thr Phe Glu Ser Asn Asn Phe Val Tyr Phe Leu 
        195                 200                 205             


Thr Val Gln Arg Glu Ser Leu Asp Ser Gln Ala Tyr His Thr Arg Ile 
    210                 215                 220                 


Val Arg Ile Cys Ser Ser Asp Ser Glu Leu Arg Ser Tyr Ile Glu Met 
225                 230                 235                 240 


Pro Leu Glu Cys Ile Phe Thr Glu Lys Arg Arg Lys Arg Ser Thr Ala 
                245                 250                 255     


Ser Ala Val Phe Asn Ile Val Gln Ala Ala Tyr Leu Gly Arg Ala Gly 
            260                 265                 270         


Glu Asp Leu Ala Glu Glu Met Gly Val Lys Pro Asp Asp Asp Ile Leu 
        275                 280                 285             


Tyr Gly Val Phe Ala Gln Ser Lys Pro Asp Ser Pro Glu Pro Asn Asn 
    290                 295                 300                 


Arg Ser Ala Val Cys Ala Val Ser Val Lys Thr Ile Asn Glu Phe Phe 
305                 310                 315                 320 


Asn Ser Ala Ala Asp Lys Gln Asn Thr Lys Cys Leu Glu His Phe Tyr 
                325                 330                 335     


Gly Lys Asp Asn Arg Leu Cys Ile Asn Asn Lys Arg Phe Leu Arg Cys 
            340                 345                 350         


Ser Thr Pro Ile Asp Glu Tyr Arg Val Glu Val Thr Thr Val Leu Arg 
        355                 360                 365             


Arg Leu Asp Leu Phe Met Asp Gln Phe Arg Asn Val Leu Leu Thr Ser 
    370                 375                 380                 


Ile Ser Val Phe Thr Gln Gly Arg Leu Thr Ile Ala Asn Leu Gly Thr 
385                 390                 395                 400 


Ser Glu Gly Arg Phe Met Gln Val Ile Ile Ser Arg Thr Gly Gln Pro 
                405                 410                 415     


Lys Pro His Val Asn Phe Leu Leu Glu Ala Arg Pro Ile Ser Pro Glu 
            420                 425                 430         


Ile Val Ile Asn Thr Ala Ser 
        435                 


<210>  30
<211>  443
<212>  PRT
<213>  Takifugu rubripes

<400>  30

Ile Gln Asn Val Val Thr Leu Asp Gly Ile Ile Tyr Val Gly Ala Thr 
1               5                   10                  15      


Asn Arg Ile Tyr Ala Leu Ala Pro Ser Leu Thr Lys Leu Ser Glu Tyr 
            20                  25                  30          


Arg Thr Gly Pro Leu Leu Ala Asn Gln Thr Cys Gly Gln Lys Val Ala 
        35                  40                  45              


Asn Ala Ser Ser Gly Gly Gly Arg Lys Asp Asn Leu Asn Val Ala Leu 
    50                  55                  60                  


Val Val Glu Asn Ile Tyr Asp Lys Gly Leu Phe Ser Cys Gly Ser Ala 
65                  70                  75                  80  


Asp Asn Gly Val Cys Arg Arg His Val Leu Glu Asp Asp Val Ser Leu 
                85                  90                  95      


Asp Glu Glu Gly Val Asp Glu Phe Thr Asp Leu Lys Gln Asp Lys Gly 
            100                 105                 110         


Gln Pro Arg Asp Ser Asp Val Val Val Ser Pro Ser Gly Ser Gln Val 
        115                 120                 125             


Leu Asn Val Glu Ser Asn Met Ile Met Phe Phe Val Gly Asn Ser Glu 
    130                 135                 140                 


Ile Pro Gly Ser Gly Asn Val Thr Gly Pro Thr Ala Arg Pro His Thr 
145                 150                 155                 160 


Met Ser Leu Arg Lys Met Lys Thr Ser Gln Asn Gly Phe Thr Phe Phe 
                165                 170                 175     


Ser Asn Arg Ser Tyr Met Asp Leu Ile Pro Pro Leu Arg Gly Ser Tyr 
            180                 185                 190         


Tyr Leu Arg Tyr Val Tyr Ser Phe His Ser Gly Pro Phe Thr Tyr Phe 
        195                 200                 205             


Leu Thr Val Gln Gln Val Ser Lys Asp Ser Gln Thr Tyr His Thr Arg 
    210                 215                 220                 


Ile Val Arg Met Cys Ser Ser Asp His Asp Ile Arg Arg Tyr Val Glu 
225                 230                 235                 240 


Met Pro Leu Glu Cys Ile Ser Thr Asp Ser Met Glu Asp Val Lys Val 
                245                 250                 255     


Phe Asn Ile Leu Gln Ala Ala Thr Val Thr Lys Val Gly Ser Asp Val 
            260                 265                 270         


Glu Leu Gln Arg Gln Leu Arg Leu Glu Glu Gly Asp Asp Val Leu Phe 
        275                 280                 285             


Ala Ala Phe Ala Arg Gly Lys Pro Asn Ser Thr Glu Ala Thr Pro Asn 
    290                 295                 300                 


Ser Ala Ile Cys Val Met Ser Leu Lys Leu Ile Asn Ser Met Phe Lys 
305                 310                 315                 320 


Met Tyr Met Gln Lys Cys Asn Thr Val Asp Leu Tyr His Phe Thr Gly 
                325                 330                 335     


Ser Asp Lys Lys Ser Cys Tyr Asn Val Ser Ser Ser Asp Asp Cys Asp 
            340                 345                 350         


Pro His Glu Gly Ile His Glu Gly Lys Glu Gly Lys Tyr Arg Leu Gln 
        355                 360                 365             


Val Thr Gln Phe Val Gln Arg Leu Glu Tyr Trp Gln Lys Val Leu Thr 
    370                 375                 380                 


Asn Thr Leu Val Thr Ser Ile Thr Val Val Thr Val His Gly Arg Ala 
385                 390                 395                 400 


Val Gly Tyr Leu Gly Thr Ala Asp Gly Arg His Ile Gln Val Val Phe 
                405                 410                 415     


Ser Arg Phe Ala Ser Pro His Val Asn Ile Arg Leu Asp Ser Arg Pro 
            420                 425                 430         


Val Ser Gly Ser Val Val Leu Pro Gly Gln Asp 
        435                 440             


<210>  31
<211>  443
<212>  PRT
<213>  Gallus gallus

<400>  31

Val Gln Asn Ile Ala Val Phe Pro Asp Pro Pro Thr Val Phe Val Ala 
1               5                   10                  15      


Val Arg Asn Arg Ile Leu Val Val Asp Pro Glu Leu Arg Leu Arg Ser 
            20                  25                  30          


Val Leu Val Thr Gly Pro Thr Gly Ser Ala Pro Cys Glu Ile Cys Arg 
        35                  40                  45              


Leu Cys Pro Ala Ala Val Asp Ala Pro Gly Pro Glu Asp Val Asp Asn 
    50                  55                  60                  


Val Leu Leu Leu Leu Asp Pro Val Glu Pro Trp Leu Tyr Ser Cys Gly 
65                  70                  75                  80  


Thr Ala Arg Arg Gly Leu Cys Tyr Leu His Gln Leu Asp Val Arg Gly 
                85                  90                  95      


Ser Glu Val Thr Ile Ala Ser Thr Arg Cys Leu Tyr Ser Ala Ala Ala 
            100                 105                 110         


Asn Ser Pro Val Asn Cys Pro Asp Cys Val Ala Ser Pro Leu Gly Ser 
        115                 120                 125             


Thr Ala Thr Val Val Ala Asp Arg Tyr Thr Ala Ser Phe Tyr Leu Gly 
    130                 135                 140                 


Ser Thr Val Asn Ser Ser Val Ala Ala Arg Tyr Ser Pro Arg Ser Val 
145                 150                 155                 160 


Ser Val Arg Arg Leu Lys Gly Thr Arg Asp Gly Phe Ala Asp Pro Phe 
                165                 170                 175     


His Ser Leu Thr Val Leu Pro His Tyr Gln Asp Val Tyr Pro Ile His 
            180                 185                 190         


Tyr Val His Ser Phe Thr Asp Gly Asp His Val Tyr Leu Val Thr Val 
        195                 200                 205             


Gln Pro Glu Phe Pro Gly Ser Ser Thr Phe His Thr Arg Leu Val Arg 
    210                 215                 220                 


Leu Ser Ala His Glu Pro Glu Leu Arg Arg Tyr Arg Glu Ile Val Leu 
225                 230                 235                 240 


Asp Cys Arg Tyr Glu Ser Glu Glu Thr Glu Arg Asp Val Ala Tyr Asn 
                245                 250                 255     


Val Leu Gln Ala Ala His Ala Ala Arg Pro Gly Ala Arg Leu Ala Arg 
            260                 265                 270         


Asp Leu Gly Ile Asp Gly Thr Glu Thr Val Leu Phe Gly Ala Phe Ala 
        275                 280                 285             


Glu Ser His Pro Glu Ser Arg Ala Pro Gln His Asn Ser Ala Val Cys 
    290                 295                 300                 


Ala Phe Pro Leu Arg Leu Leu Asn Gln Ala Ile Arg Glu Gly Met Asp 
305                 310                 315                 320 


Lys Cys Cys Gly Thr Gly Thr Gln Thr Leu Lys Arg Gly Leu Ala Phe 
                325                 330                 335     


Phe Gln Pro Gln Gln Tyr Cys Pro His Ser Val Asn Leu Ser Ala Pro 
            340                 345                 350         


Val Thr Asn Thr Ser Cys Trp Asp Gln Pro Thr Leu Val Pro Ala Ala 
        355                 360                 365             


Ser His Lys Val Asp Leu Phe Asn Gly Arg Leu Ser Gly Thr Leu Leu 
    370                 375                 380                 


Thr Ser Ile Phe Val Thr Val Leu Gln Asn Val Thr Val Ala His Leu 
385                 390                 395                 400 


Gly Thr Ala Gln Gly Arg Val Leu Gln Met Val Leu Gln Arg Ser Ser 
                405                 410                 415     


Ser Tyr Val Val Ala Leu Thr Asn Phe Ser Leu Gly Glu Pro Gly Leu 
            420                 425                 430         


Val Gln His Ala Thr Gly Leu Gln Gly His Ser 
        435                 440             


<210>  32
<211>  405
<212>  PRT
<213>  Takifugu rubripes

<400>  32

Ile Gln Asn Ile Val Asn Asn Ser Phe Tyr Gln Glu Val Tyr Val Ala 
1               5                   10                  15      


Ser Gln Asn Val Ile Glu Ala Val Asn Gln Ser Leu Glu Lys Val Trp 
            20                  25                  30          


Glu Leu Arg Thr Gly Pro Val Gly Ser Pro Glu Cys Lys Ile Cys Asp 
        35                  40                  45              


Leu Cys Asn Thr Asp Lys Asp Pro Ser Leu Glu Asp Thr Asn Asn Glu 
    50                  55                  60                  


Val Leu Leu Leu Asp Thr Leu Phe Met Tyr Leu Tyr Thr Cys Gly Ser 
65                  70                  75                  80  


Ser Gln Tyr Gly Val Cys Tyr Phe His Gln Leu Asn Ser Thr Gly Glu 
                85                  90                  95      


Pro Pro Ser Leu Ser Lys Cys Leu Tyr Arg Lys Lys Ser Asn Ser Ala 
            100                 105                 110         


Ala Tyr Cys Pro Asp Cys Val Ala Ser Ser Leu Gly Thr Lys Val Thr 
        115                 120                 125             


Met Val Glu Glu Gly Gln Thr Val Tyr Phe Phe Val Ala Thr Thr Val 
    130                 135                 140                 


Asn Asp Ser Val Thr Gln Arg Tyr Gly Arg Lys Ser Leu Ser Val Arg 
145                 150                 155                 160 


Arg Pro Leu Ala Thr Glu Asp Gly Phe Tyr Ser Asp Val Arg Gly Leu 
                165                 170                 175     


Thr Val Leu Pro Ser Leu Arg Asn Thr Tyr His Ile Glu Tyr Val Tyr 
            180                 185                 190         


Ser Phe Phe Thr Gln Glu Phe Val Phe Phe Leu Ser Val Gln Arg Glu 
        195                 200                 205             


Ser Pro Asp Gln Glu Ser Ser Pro Phe Gln Thr Arg Leu Gly Arg Leu 
    210                 215                 220                 


Pro Arg Asn Glu Trp Glu Met Lys Arg Tyr Arg Glu Val Ile Leu Glu 
225                 230                 235                 240 


Cys Arg Phe Glu Pro Gly Ser Glu Pro Tyr Lys Asp Val Val Tyr Asn 
                245                 250                 255     


Val Val Gln Ala Ala His Phe Ala Lys Ala Gly Arg Glu Leu Ala Glu 
            260                 265                 270         


Glu Leu Gly Ala Glu Glu Glu Asp Asp Ile Leu Tyr Gly Val Phe Ala 
        275                 280                 285             


Val Thr Asp Asp Asn Gly Val Thr Glu His Asp Ser Ala Leu Cys Ala 
    290                 295                 300                 


Phe Pro Val Asp Asn Val Asn Lys Ala Ile Ala Asp Gly Val Asp Asp 
305                 310                 315                 320 


Cys Cys Gln Ser Gly Pro Glu Gln Leu Ser Arg Gly Leu Cys His Phe 
                325                 330                 335     


Gln Pro Cys Glu Ser Cys Pro His Glu Ser Met Glu Asn Asn Ala Thr 
            340                 345                 350         


Cys Arg Asp Gln Pro Thr Met Val Ser Lys Pro Tyr Tyr Arg Val Asp 
        355                 360                 365             


Leu Phe Asn Arg Gln Met Thr Asp Val Leu Leu Thr Ser Leu Leu Val 
    370                 375                 380                 


Thr Thr Ile Glu Asn Lys Thr Val Ala His Ile Gly Thr Ser Thr Gly 
385                 390                 395                 400 


Arg Leu Leu Gln Leu 
                405 


<210>  33
<211>  435
<212>  PRT
<213>  Takifugu rubripes

<400>  33

Val Gln Asn Ile Ala Val Asn Trp Asp Ser Gln Gln Lys Glu Ile Tyr 
1               5                   10                  15      


Ile Gly Cys Gln Asn Ala Ile Lys Ala Val Ser Gly Thr Leu Glu Glu 
            20                  25                  30          


Met Trp Glu Val Lys Thr Gly Pro Val Gly Ser Pro Asp Cys Glu Thr 
        35                  40                  45              


Cys Lys Leu Cys Asp Val Glu Ala Asp Pro Glu Asp Pro Val Asp Thr 
    50                  55                  60                  


Asp Ser Glu Val Leu Val Leu Asp Pro Ala Gly Ile Leu Leu Pro Tyr 
65                  70                  75                  80  


Leu Tyr Val Cys Gly Ser Thr Gln His Gly Ile Cys Tyr Phe Ile Asp 
                85                  90                  95      


Ile Glu Ser Pro Glu His Ala Pro Gln Cys Leu Tyr Lys Lys Gln Arg 
            100                 105                 110         


Asn Ser Pro Thr Arg Cys Pro Asp Cys Leu Ala Ser Pro Leu Gly Thr 
        115                 120                 125             


Lys Val Ser Ile Ile Glu Asp Gly Ser Thr Thr Tyr Phe Phe Val Ala 
    130                 135                 140                 


Ala Ala Val Asp Asp Arg Val Ala Gln Arg Tyr Pro Arg Arg Ser Ile 
145                 150                 155                 160 


Ser Val Met Arg Pro Leu Ser Thr Glu Asp Gly Phe Glu Met Val Thr 
                165                 170                 175     


Asp Gly Leu Thr Val Leu Pro Ser Arg Ser Thr Tyr Lys Ile Asp Tyr 
            180                 185                 190         


Ile His Ser Phe Ala Thr Lys Glu Tyr Val Tyr Phe Leu Ser Leu Gln 
        195                 200                 205             


Arg Glu Asn Pro Ser Asn Ser Asn Ser Pro Leu Gln Thr Arg Leu Gly 
    210                 215                 220                 


Arg Leu Pro Ile Ser Ile Arg Glu Val Trp Met Tyr Arg Glu Val Val 
225                 230                 235                 240 


Leu Glu Cys His Phe Asn Pro Gly Asp Phe Arg Gly Ile Val Tyr Asn 
                245                 250                 255     


Gly Leu Gln Ala Ala His Phe Gly Arg Ala Gly Lys Asp Leu Ala Glu 
            260                 265                 270         


Glu Leu Arg Val Asp Glu Gln Glu Asp Ile Leu Tyr Gly Val Phe Ala 
        275                 280                 285             


Val Val Asn Glu Leu Gly Glu Thr Gln Arg Asn Ser Ala Leu Cys Ala 
    290                 295                 300                 


Phe Pro Leu Ser Lys Val Asn His Ala Ile Asp Glu Gly Val Glu Ala 
305                 310                 315                 320 


Cys Cys Arg Ser Gly Thr Glu Gln Leu Ser Arg Gly Leu Gly His Phe 
                325                 330                 335     


Gln Pro Leu Glu Ser Cys Pro His Glu Ser Ser Glu Asp Lys Tyr Thr 
            340                 345                 350         


Cys Arg Ser Lys Pro Thr Leu Val Ala Gln Pro His Tyr Arg Leu Asp 
        355                 360                 365             


Leu Phe Asn Arg Lys Met Arg Asp Val Leu Phe Thr Thr Val Met Val 
    370                 375                 380                 


Thr Thr Thr Gly Asn His Thr Leu Gly His Phe Gly Thr Ser Asp Gly 
385                 390                 395                 400 


Arg Ile Leu Gln Val Ile Leu Ser Leu Tyr Arg Pro Ile Val Phe Ala 
                405                 410                 415     


Asn Tyr Ser Leu Gly Asp Gly Glu Val Ser Arg Thr Ala Ala Val Tyr 
            420                 425                 430         


Ser Glu Asp 
        435 


<210>  34
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  34

Val Gln Ala Met Val Thr Tyr Glu Gly Asp Arg Asn Glu Ser Ala Val 
1               5                   10                  15      


Phe Val Ala Ile Arg Asn Arg Leu His Val Leu Gly Pro Asp Leu Lys 
            20                  25                  30          


Ser Val Gln Ser Leu Ala Thr Gly Pro Ala Gly Asp Pro Gly Cys Gln 
        35                  40                  45              


Thr Cys Ala Ala Cys Gly Pro Gly Pro His Gly Pro Pro Gly Asp Thr 
    50                  55                  60                  


Asp Thr Lys Val Leu Val Leu Asp Pro Ala Leu Pro Ala Leu Val Ser 
65                  70                  75                  80  


Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe Leu His Asp Leu Glu Pro 
                85                  90                  95      


Gln Gly Thr Ala Val His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala 
            100                 105                 110         


His His Asn Arg Pro Asp Asp Cys Pro Asp Cys Val Ala Ser Pro Leu 
        115                 120                 125             


Gly Thr Arg Val Thr Val Val Glu Gln Gly Gln Ala Ser Tyr Phe Tyr 
    130                 135                 140                 


Val Ala Ser Ser Leu Asp Ala Ala Val Ala Gly Ser Phe Ser Pro Arg 
145                 150                 155                 160 


Ser Val Ser Ile Arg Arg Leu Lys Ala Asp Ala Ser Gly Phe Ala Pro 
                165                 170                 175     


Gly Phe Val Ala Leu Ser Val Leu Pro Lys His Leu Val Ser Tyr Ser 
            180                 185                 190         


Ile Glu Tyr Val His Ser Phe His Thr Gly Ala Phe Val Tyr Phe Leu 
        195                 200                 205             


Thr Val Gln Pro Ala Ser Val Thr Asp Asp Pro Ser Ala Leu His Thr 
    210                 215                 220                 


Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro Glu Leu Gly Asp Tyr Arg 
225                 230                 235                 240 


Glu Leu Val Leu Asp Cys Arg Phe Ala Pro Gly Ala Pro Glu Gly Gly 
                245                 250                 255     


Gln Pro Tyr Pro Val Leu Gln Val Ala His Ser Ala Pro Val Gly Ala 
            260                 265                 270         


Gln Leu Ala Thr Glu Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe 
        275                 280                 285             


Gly Val Phe Val Thr Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn 
    290                 295                 300                 


Ser Val Val Cys Ala Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp 
305                 310                 315                 320 


Glu Gly Val Glu Arg Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg 
                325                 330                 335     


Arg Gly Leu Asp Phe Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro 
            340                 345                 350         


Gly Leu Glu Ala Leu Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu 
        355                 360                 365             


Leu Val Ser Ser Ser Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu 
    370                 375                 380                 


Gly Pro Val Gln Val Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val 
385                 390                 395                 400 


Thr Val Ala His Met Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu 
                405                 410                 415     


Leu Val Arg Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu 
            420                 425                 430         


Gly Asp Ser Gly Gln Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp 
        435                 440                 445             


His 
    


<210>  35
<211>  444
<212>  PRT
<213>  Mus musculus

<400>  35

Val Gln Ala Thr Ala Ala Tyr Glu Asp Ser Thr Asn Ser Ala Val Phe 
1               5                   10                  15      


Val Ala Thr Arg Asn His Leu His Val Leu Gly Pro Asp Leu Gln Phe 
            20                  25                  30          


Ile Glu Asn Leu Thr Thr Gly Pro Ile Gly Asn Pro Gly Cys Gln Thr 
        35                  40                  45              


Cys Ala Ser Cys Gly Pro Gly Pro His Gly Pro Pro Lys Asp Thr Asp 
    50                  55                  60                  


Thr Leu Val Leu Val Met Glu Pro Gly Leu Pro Ala Leu Val Ser Cys 
65                  70                  75                  80  


Gly Ser Thr Leu Gln Gly Arg Cys Phe Leu His Glu Leu Glu Pro Arg 
                85                  90                  95      


Gly Lys Ala Leu His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala Asn 
            100                 105                 110         


Asn Asn Lys Pro Glu Ala Cys Thr Asp Cys Val Ala Ser Pro Leu Gly 
        115                 120                 125             


Thr Arg Val Thr Val Val Glu Gln Gly His Ala Ser Tyr Phe Tyr Val 
    130                 135                 140                 


Ala Ser Ser Leu Asp Pro Glu Leu Ala Ala Ser Phe Ser Pro Arg Ser 
145                 150                 155                 160 


Val Ser Ile Arg Arg Leu Lys Ser Asp Thr Ser Gly Phe Gln Pro Gly 
                165                 170                 175     


Phe Pro Ser Leu Ser Val Leu Pro Lys Tyr Leu Ala Ser Tyr Leu Ile 
            180                 185                 190         


Lys Tyr Val Tyr Ser Phe His Ser Gly Asp Phe Val Tyr Phe Leu Thr 
        195                 200                 205             


Val Gln Pro Ile Ser Val Thr Ser Pro Pro Ser Ala Leu His Thr Arg 
    210                 215                 220                 


Leu Val Arg Leu Asn Ala Val Glu Pro Glu Ile Gly Asp Tyr Arg Glu 
225                 230                 235                 240 


Leu Val Leu Asp Cys His Phe Ala Pro Ala Pro Glu Gly Thr Gln Pro 
                245                 250                 255     


Tyr Pro Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu 
            260                 265                 270         


Ala Val Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val 
        275                 280                 285             


Phe Val Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val 
    290                 295                 300                 


Val Cys Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly 
305                 310                 315                 320 


Val Glu Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg 
                325                 330                 335     


Gly Leu Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly 
            340                 345                 350         


Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His Ala Ser 
        355                 360                 365             


Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val Lys Val 
    370                 375                 380                 


Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala His Met 
385                 390                 395                 400 


Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg Ser Leu 
                405                 410                 415     


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser Gly Gln 
            420                 425                 430         


Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp 
        435                 440                 


<210>  36
<211>  434
<212>  PRT
<213>  Xenopus laevis

<400>  36

Ile Gln Asn Leu Val Ser Gln Glu Asp Leu Leu Phe Leu Thr Thr Thr 
1               5                   10                  15      


Asn His Leu Tyr Val Leu Thr Gly Asn Glu Leu His Met Leu Gln Asn 
            20                  25                  30          


Leu Thr Thr Gly Pro Thr Asn Ser Gln Cys Thr Leu Cys Ser Lys Cys 
        35                  40                  45              


Gln Met Gly Asn Ala Leu Pro Ser Gln Pro Glu Asp Thr Glu Ser Gln 
    50                  55                  60                  


Val Leu Val Ala Asp Pro Glu Glu Ser Val Ile Tyr Ser Cys Gly Ser 
65                  70                  75                  80  


Ser Leu His Gly Leu Cys Phe Met His Val Ile Ala Ser Ser Lys Ile 
                85                  90                  95      


Val Asp Ser Lys Cys Leu Phe Asn Gln Asn Arg Asn Asn Ala Ser Ser 
            100                 105                 110         


Cys Pro Asp Cys Ile Ala Ser Pro Leu Gly Thr Leu Leu Thr Val Val 
        115                 120                 125             


Thr Gln Ser Arg Val Val Tyr Phe Tyr Thr Ala Ser Ser Leu Asp Ser 
    130                 135                 140                 


Pro Ile Ala Lys Ser Tyr Ser Pro Thr Ser Ile Ser Ile Arg Arg Leu 
145                 150                 155                 160 


Leu Gly Ser Glu Asp Gly Phe Gly Gly Gly Phe His Ser Leu Thr Val 
                165                 170                 175     


Leu Glu Thr Phe Arg Asp Ser Tyr Pro Ile His Tyr Val His Thr Phe 
            180                 185                 190         


Thr Ser Gly Ser Tyr Val Tyr Phe Leu Thr Val Gln Pro Glu His Pro 
        195                 200                 205             


Leu Ser Ser Thr Tyr His Ser Arg Val Val Arg Leu Tyr Lys Lys Glu 
    210                 215                 220                 


Glu Glu Met Arg Ser Tyr Arg Glu Leu Ile Leu Glu Cys Arg Leu Glu 
225                 230                 235                 240 


Pro Arg Arg Arg Ala Glu Pro Arg Ile Phe Asn Val Leu Gln Ala Ala 
                245                 250                 255     


His Val Ala Thr Val Gly Ser Thr Leu Ala Gly Glu Leu Asp Ile Ser 
            260                 265                 270         


Glu Thr Asp Pro Val Leu Phe Ala Val Phe Ala Gln Ser Glu Pro Met 
        275                 280                 285             


Ser Ala Gln Pro Arg Lys Tyr Ser Ala Val Cys Ala Phe Pro Ile Ser 
    290                 295                 300                 


Leu Ile Asp Leu Ser Ile Glu Asp Gly Met Asn Ala Cys Cys Ser Asn 
305                 310                 315                 320 


Thr Asn Ser Val Arg Leu Thr Arg Gly Leu Asn Phe Phe Gln Pro Glu 
                325                 330                 335     


Met Glu Cys Pro Gln Asn Asp Asn Gln Ser Asp Ile Thr Cys Lys Asn 
            340                 345                 350         


Val Pro Thr Leu Val Ser Pro Pro Leu Arg Arg Val Asp Ile Phe Asn 
        355                 360                 365             


Gly Gln Leu Asp Gly Val Leu Leu Thr Ser Met Tyr Val Arg Pro Gln 
    370                 375                 380                 


Glu Asp Leu Thr Ile Gly Phe Leu Gly Thr Ser Val Gly Arg Leu Leu 
385                 390                 395                 400 


Gln Val Val Leu Gln Arg Asn Ser Lys Pro Arg Thr Leu Ser Asn Phe 
                405                 410                 415     


Ser Ile Ser Asp Thr His Pro Val Ser Arg Glu Val Thr Arg Ile Arg 
            420                 425                 430         


Asp Ser 
        


<210>  37
<211>  431
<212>  PRT
<213>  Mus musculus

<400>  37

Leu Thr His Leu Val Val His Asn Lys Thr Gly Glu Val Tyr Val Gly 
1               5                   10                  15      


Ala Ile Asn Arg Ile Tyr Lys Leu Ser Asn Asn Leu Thr Leu Leu Arg 
            20                  25                  30          


Thr His Val Thr Gly Pro Val Glu Asp Asn Glu Lys Cys Tyr Pro Pro 
        35                  40                  45              


Pro Ser Val Gln Ser Cys Pro His Gly Leu Ile Thr Thr Asn Asn Val 
    50                  55                  60                  


Asn Lys Leu Leu Leu Ile Asp Tyr Ser Asp Asn Arg Leu Ile Ala Cys 
65                  70                  75                  80  


Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp Asp Leu 
                85                  90                  95      


Phe Lys Leu Gly Arg Lys Glu His Tyr Leu Ser Ser Val Asn Glu Ser 
            100                 105                 110         


Gly Thr Met Ser Gly Val Ile Ile Glu Val Pro Asn Gly Gln Asn Lys 
        115                 120                 125             


Leu Phe Val Gly Thr Pro Ile Asp Gly Lys Ser Glu Tyr Phe Pro Thr 
    130                 135                 140                 


Leu Ser Ser Arg Lys Leu Leu Gly Asn Glu Glu Asn Ala Glu Met Phe 
145                 150                 155                 160 


Gly Phe Val Tyr Gln Asp Glu Phe Val Ser Ser Gln Leu Lys Ile Pro 
                165                 170                 175     


Ser Phe Pro Thr Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Ser Ser Glu 
            180                 185                 190         


Gln Phe Val Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu Ser Thr 
        195                 200                 205             


Gly Glu Gln Phe Phe Thr Ser Lys Ile Val Arg Leu Cys Val Asp Asp 
    210                 215                 220                 


Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Met Lys Asp 
225                 230                 235                 240 


Gly Val Glu Tyr Arg Leu Ile Gln Asp Ala Tyr Leu Ser Lys Pro Gly 
                245                 250                 255     


Lys Arg Leu Ala Lys Glu Leu Gly Ile Ser Glu Arg Glu Asp Ile Leu 
            260                 265                 270         


Phe Thr Val Phe Ser Gln Gly Gln Lys Asn Arg Ile Lys Pro Pro Lys 
        275                 280                 285             


Glu Ser Val Leu Cys Leu Phe Thr Leu Lys Lys Ile Lys Asp Lys Ile 
    290                 295                 300                 


Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Asp Gly Lys Leu Ser Leu 
305                 310                 315                 320 


Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser Pro Leu Gln 
                325                 330                 335     


Ile Asp Asp Asn Phe Cys Gly Gln Asp Phe Asn Gln Pro Leu Gly Gly 
            340                 345                 350         


Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Leu Asp Lys Glu Asp Gly 
        355                 360                 365             


Met Thr Ser Val Ala Ala Tyr Asp Tyr Arg Gly His Thr Val Val Phe 
    370                 375                 380                 


Ala Gly Thr Arg Ser Gly Arg Val Lys Lys Ile Leu Val Asp Leu Ser 
385                 390                 395                 400 


Ala Ser Ser Ser His Leu Val Gln Gln Tyr Glu Asn Val Val Val His 
                405                 410                 415     


Glu Gly Asn Ala Ile Leu Arg Asp Leu Val Leu Ser Pro Asp Arg 
            420                 425                 430     


<210>  38
<211>  427
<212>  PRT
<213>  Mus musculus

<400>  38

Leu Thr His Leu Ala Val His Arg Val Thr Gly Glu Val Phe Val Gly 
1               5                   10                  15      


Ala Val Asn Arg Val Phe Lys Leu Ala Pro Asn Leu Thr Glu Leu Arg 
            20                  25                  30          


Ala His Val Thr Gly Pro Ile Glu Asp Asn Ala Arg Cys Tyr Pro Pro 
        35                  40                  45              


Pro Ser Met Arg Val Cys Ser His Arg Leu Val Pro Val Asp Asn Val 
    50                  55                  60                  


Asn Lys Leu Leu Leu Ile Asp Tyr Ala Ala Arg Arg Leu Val Ala Cys 
65                  70                  75                  80  


Gly Ser Ile Trp Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp Asp Leu 
                85                  90                  95      


Phe Lys Leu Gly Arg Lys Glu His Tyr Leu Ser Gly Ala Gln Glu Pro 
            100                 105                 110         


Asp Ser Met Ala Gly Val Ile Val Glu Gln Val Gln Gly Pro Ser Lys 
        115                 120                 125             


Leu Phe Val Gly Thr Ala Val Asp Gly Lys Ser Glu Tyr Phe Pro Thr 
    130                 135                 140                 


Leu Ser Ser Arg Lys Leu Ile Asp Asp Glu Asp Ser Gly Asp Met Phe 
145                 150                 155                 160 


Ser Leu Val Tyr Gln Asp Glu Phe Val Ser Ser Gln Ile Lys Ile Pro 
                165                 170                 175     


Ser Tyr Pro Ala Phe Asp Ile Tyr Tyr Ile Tyr Gly Phe Val Ser Ala 
            180                 185                 190         


Ser Phe Val Tyr Phe Leu Thr Leu Gln Leu Asp Thr Gln Gln Thr Ala 
        195                 200                 205             


Gly Glu Lys Phe Phe Thr Ser Lys Ile Val Arg Met Cys Ala Gly Asp 
    210                 215                 220                 


Ser Glu Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Ser Trp Arg 
225                 230                 235                 240 


Gly Val Glu Tyr Arg Leu Val Gln Ser Ala His Leu Ala Lys Pro Gly 
                245                 250                 255     


Leu Leu Leu Ala Gln Ala Leu Gly Val Pro Ala Asp Glu Asp Val Leu 
            260                 265                 270         


Phe Thr Ile Phe Ser Gln Gly Gln Lys Asn Arg Ala Asn Pro Pro Arg 
        275                 280                 285             


Gln Thr Ile Leu Cys Leu Phe Thr Leu Ser Ser Ile Asn Ala His Ile 
    290                 295                 300                 


Arg Arg Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Ala Leu 
305                 310                 315                 320 


Pro Trp Leu Leu Asn Lys Glu Leu Pro Cys Ile Asn Thr Pro Leu Gln 
                325                 330                 335     


Ile Asn Gly Asn Phe Cys Gly Leu Val Leu Asn Gln Pro Leu Gly Gly 
            340                 345                 350         


Leu His Val Ile Glu Gly Leu Pro Leu Leu Ala Asp Ser Thr Asp Gly 
        355                 360                 365             


Met Ala Ser Val Ala Ala Tyr Thr Tyr His Gln His Ser Val Val Phe 
    370                 375                 380                 


Ile Gly Thr Arg Ser Gly Asn Leu Lys Lys Val Arg Val Asp Gly Ser 
385                 390                 395                 400 


Gln Asp Ala Gln Leu Tyr Glu Thr Val Ser Val Val Gln Gly Ser Pro 
                405                 410                 415     


Ile Leu Arg Asp Leu Leu Phe Ser Pro Asp His 
            420                 425         


<210>  39
<211>  433
<212>  PRT
<213>  Mus musculus

<400>  39

Leu Thr His Leu Val Val His Glu Gln Thr Gly Glu Val Tyr Val Gly 
1               5                   10                  15      


Ala Val Asn Arg Ile Tyr Lys Leu Ser Gly Asn Leu Thr Leu Leu Arg 
            20                  25                  30          


Ala His Val Thr Gly Pro Val Glu Asp Asn Glu Lys Cys Tyr Pro Pro 
        35                  40                  45              


Pro Ser Val Gln Ser Cys Pro His Gly Leu Gly Ser Thr Asp Asn Val 
    50                  55                  60                  


Asn Lys Leu Leu Leu Leu Asp Tyr Ala Ala Asn Arg Leu Leu Ala Cys 
65                  70                  75                  80  


Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp Asp Leu 
                85                  90                  95      


Phe Lys Leu Gly Arg Lys Glu His Tyr Leu Ser Ser Val Arg Glu Ala 
            100                 105                 110         


Gly Ser Met Ala Gly Val Leu Ile Ala Gly Pro Pro Gly Gln Gly Gln 
        115                 120                 125             


Ala Lys Leu Phe Val Gly Thr Pro Ile Asp Gly Lys Ser Glu Tyr Phe 
    130                 135                 140                 


Pro Thr Leu Ser Ser Arg Arg Leu Met Ala Asn Glu Glu Asp Ala Asp 
145                 150                 155                 160 


Met Phe Gly Phe Val Tyr Gln Asp Glu Phe Val Ser Ser Gln Leu Lys 
                165                 170                 175     


Ile Pro Ser Phe Pro Ala Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Arg 
            180                 185                 190         


Ser Glu Gln Phe Val Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu 
        195                 200                 205             


Ala Ala Gly Glu His Phe Phe Thr Ser Lys Ile Val Arg Leu Cys Val 
    210                 215                 220                 


Asn Asp Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Glu 
225                 230                 235                 240 


Gln Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala Tyr Leu Ser Arg 
                245                 250                 255     


Pro Gly Gln Ala Leu Ala Lys Gln Leu Gly Leu Ala Glu Asp Glu Glu 
            260                 265                 270         


Val Leu Phe Thr Val Phe Ala Gln Gly Gln Lys Asn Arg Val Lys Pro 
        275                 280                 285             


Pro Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg Ala Ile Lys Glu 
    290                 295                 300                 


Lys Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Lys Leu 
305                 310                 315                 320 


Ser Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser Pro 
                325                 330                 335     


Leu Gln Ile Asp Asp Asp Phe Cys Gly Gln Asp Phe Asn Gln Pro Leu 
            340                 345                 350         


Gly Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Val Asp Lys Glu 
        355                 360                 365             


Asp Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Gln Gly Arg Thr Val 
    370                 375                 380                 


Val Phe Ala Gly Thr Arg Ser Gly Arg Ile Arg Lys Ile Leu Val Asp 
385                 390                 395                 400 


Leu Ala Asn Pro Ser Gly Arg Pro Ala Leu Ala Tyr Glu Ser Val Val 
                405                 410                 415     


Ala Gln Glu Gly Asn Pro Ile Leu Arg Asp Leu Val Leu Ser Pro Asn 
            420                 425                 430         


Arg 
    


<210>  40
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  40

Phe Asn His Leu Thr Val His Gln Gly Thr Gly Ala Val Tyr Val Gly 
1               5                   10                  15      


Ala Ile Asn Arg Val Tyr Lys Leu Thr Gly Asn Leu Thr Ile Gln Val 
            20                  25                  30          


Ala His Lys Thr Gly Pro Glu Glu Asp Asn Lys Ser Cys Tyr Pro Pro 
        35                  40                  45              


Leu Ile Val Gln Pro Cys Ser Glu Val Leu Thr Leu Thr Asn Asn Val 
    50                  55                  60                  


Asn Lys Leu Leu Ile Ile Asp Tyr Ser Glu Asn Arg Leu Leu Ala Cys 
65                  70                  75                  80  


Gly Ser Leu Tyr Gln Gly Val Cys Lys Leu Leu Arg Leu Asp Asp Leu 
                85                  90                  95      


Phe Ile Leu Val Lys Lys Glu His Tyr Leu Ser Ser Val Asn Lys Thr 
            100                 105                 110         


Gly Thr Met Tyr Gly Val Ile Val Arg Ser Glu Gly Glu Asp Gly Lys 
        115                 120                 125             


Leu Phe Ile Gly Thr Ala Val Asp Gly Lys Gln Asp Tyr Phe Pro Thr 
    130                 135                 140                 


Leu Ser Ser Arg Lys Leu Pro Arg Asp Pro Glu Ser Ser Ala Met Leu 
145                 150                 155                 160 


Asp Tyr Glu Leu His Ser Asp Phe Val Ser Ser Leu Ile Lys Ile Pro 
                165                 170                 175     


Ser Val Ser His Phe Asp Ile Phe Tyr Ile Tyr Gly Phe Ala Ser Gly 
            180                 185                 190         


Gly Phe Val Tyr Phe Leu Thr Val Gln Pro Glu Thr Pro Glu Ser Ala 
        195                 200                 205             


Gly Asp Leu Phe Tyr Thr Ser Arg Ile Val Arg Leu Cys Lys Asp Asp 
    210                 215                 220                 


Pro Lys Phe His Ser Tyr Val Ser Leu Pro Phe Gly Cys Thr Arg Ala 
225                 230                 235                 240 


Gly Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ala Lys Pro Gly 
                245                 250                 255     


Asp Ser Leu Ala Gln Ala Phe Asn Ile Thr Ser Gln Asp Asp Val Leu 
            260                 265                 270         


Phe Ala Ile Phe Ser Lys Gly Gln Lys Gln Tyr His His Pro Pro Asp 
        275                 280                 285             


Asp Ser Ala Leu Cys Ala Phe Pro Ile Arg Ala Ile Asn Leu Gln Ile 
    290                 295                 300                 


Lys Gly Arg Leu Gln Ser Cys Tyr Gln Gly Glu Gly Asn Leu Glu Leu 
305                 310                 315                 320 


Asn Trp Leu Leu Gly Lys Asp Val Gln Cys Thr Lys Ala Pro Val Pro 
                325                 330                 335     


Ile Asp Asp Asn Phe Cys Gly Leu Asp Ile Asn Gln Pro Leu Gly Gly 
            340                 345                 350         


Ser Thr Pro Val Glu Gly Leu Thr Leu Tyr Thr Thr Ser Arg Asp Arg 
        355                 360                 365             


Met Thr Ser Val Ala Ser Tyr Val Tyr Asn Gly Tyr Ser Val Val Phe 
    370                 375                 380                 


Val Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Ala Asp Gly Pro 
385                 390                 395                 400 


Pro His Gly Gly Val Gln Tyr Glu Met Val Ser Val Leu Lys Asp Gly 
                405                 410                 415     


Ser Pro Ile Leu Arg Asp Met Ala Phe Ser Ile Asp Gln 
            420                 425                 


<210>  41
<211>  430
<212>  PRT
<213>  Drosophila melanogaster

<400>  41

Leu Asn His Leu Leu Val Asp Thr Ile Thr Gly Arg Val Phe Val Gly 
1               5                   10                  15      


Gly Val Asn Arg Leu Tyr Gln Leu Ser Pro Asp Leu Glu Leu Ser Glu 
            20                  25                  30          


Thr Val Lys Thr Gly Pro Gln Asn Asp Ser Val Glu Cys Ser Ile Leu 
        35                  40                  45              


Asp Cys Pro Leu Asn Ala Val Arg Ser Pro Thr Asp Asn Tyr Asn Lys 
    50                  55                  60                  


Val Leu Leu Ile Asp Arg Ala Thr Ser Arg Leu Ile Ala Cys Gly Ser 
65                  70                  75                  80  


Leu Phe Gln Gly Thr Cys Thr Val Arg Asn Leu Gln Asn Val Ser Ile 
                85                  90                  95      


Ile Glu His Glu Val Pro Asp Ala Val Val Ala Asn Asp Ala Asn Ser 
            100                 105                 110         


Ser Thr Val Ala Phe Ile Ala Pro Gly Pro Pro Gln His Pro Val Thr 
        115                 120                 125             


Asn Val Met Tyr Val Gly Val Thr Tyr Thr Asn Asn Ser Pro Tyr Arg 
    130                 135                 140                 


Ser Glu Ile Pro Ala Val Ala Ser Arg Ser Leu Glu Lys Thr Lys Met 
145                 150                 155                 160 


Phe Gln Ile Ala Ser Ser Ala Val Thr Thr Gly Thr Arg Thr Phe Ile 
                165                 170                 175     


Asn Ser Tyr Ala Arg Glu Thr Tyr Phe Val Asn Tyr Val Tyr Gly Phe 
            180                 185                 190         


Ser Ser Glu Arg Phe Ser Tyr Phe Leu Thr Thr Gln Leu Lys His Ser 
        195                 200                 205             


His His Ser Ser Pro Lys Glu Tyr Ile Thr Lys Leu Val Arg Ile Cys 
    210                 215                 220                 


Gln Glu Asp Ser Asn Tyr Tyr Ser Tyr Thr Glu Ile Pro Val Glu Cys 
225                 230                 235                 240 


Ile Ser Asp Ala Gln Gly Gly Thr Lys Phe Asn Leu Val Gln Ala Gly 
                245                 250                 255     


Phe Leu Gly Lys Pro Ser Ser Asn Leu Ala Gln Ser Leu Gly Ile Ser 
            260                 265                 270         


Ile Gln Asn Asp Val Leu Phe Ala Val Phe Ser Lys Gly Glu Gly Asn 
        275                 280                 285             


Thr Pro Thr Asn Asn Ser Ala Leu Cys Ile Tyr Ser Leu Lys Ser Ile 
    290                 295                 300                 


Arg Arg Lys Phe Met Gln Asn Ile Lys Ser Cys Phe Asn Gly Ser Gly 
305                 310                 315                 320 


Met Arg Gly Leu Asn Phe Ile Ser Pro Ser Met Pro Cys Val Leu Thr 
                325                 330                 335     


Lys Leu Gln Thr Ile Gly Glu Asp Phe Cys Gly Leu Asp Val Asn Ser 
            340                 345                 350         


Pro Leu Gly Gly Glu Thr Pro Ile Thr Ser Val Pro Val Ala Met Phe 
        355                 360                 365             


Asn Thr Lys Leu Thr Ser Val Ala Ala Thr Ser Thr Ser Gly Tyr Thr 
    370                 375                 380                 


Val Val Phe Val Gly Thr Ser Asp Gly Phe Leu Lys Lys Val Val Ile 
385                 390                 395                 400 


Glu Ser Ser Ser Ile Ala Asn Glu Tyr Ala Ser Phe Ala Val Asp Leu 
                405                 410                 415     


Gly Ser Glu Ile Asn Arg Asp Met Gln Phe Asp Asn Gln Asn 
            420                 425                 430 


<210>  42
<211>  431
<212>  PRT
<213>  Drosophila melanogaster

<400>  42

Phe Thr His Met Ser Phe Asp Phe Met His Asn Val Leu Phe Ala Gly 
1               5                   10                  15      


Ala Thr Asn Lys Ile Leu Lys Leu Asn Glu Asn Leu Arg Val Leu Ala 
            20                  25                  30          


Glu Ala Val Thr Gly Pro Leu His Asp Ser Pro Gln Cys His Ala Gly 
        35                  40                  45              


Gly Cys Pro Glu Asp Ile Glu Thr Ser Leu Val Asn Asn Phe Asn Lys 
    50                  55                  60                  


Ile Leu Val Val Ser Tyr Ala His Asp Gly Ile Leu Ile Ala Cys Gly 
65                  70                  75                  80  


Ser Ile Arg Gln Gly Ala Cys Glu Ile Tyr Ser Leu Pro Arg Phe Pro 
                85                  90                  95      


Ala Thr Pro Gln Phe Phe Ala Val Pro Leu Ala Ala Asn Asp Glu Asn 
            100                 105                 110         


Ala Ser Thr Tyr Ala Phe Val Gly Pro Ala Arg Tyr Ala Trp Lys Glu 
        115                 120                 125             


Glu Asp Ile Leu Tyr Val Gly Thr Thr Phe Thr Asn Val Gly Asp Tyr 
    130                 135                 140                 


Arg His Asp Val Pro Ala Ile Ser Ser Arg Arg Leu Asp Asp Leu Asn 
145                 150                 155                 160 


Tyr Ala Glu Phe Ser Ile Gln Gln Ser Ile Ile Asn Ile Asp Val Lys 
                165                 170                 175     


Tyr Arg Asp His Phe Leu Val Asp Tyr Ile Tyr Gly Phe Asn Ser Ser 
            180                 185                 190         


Glu Tyr Ala Tyr Phe Ile Ile Val Gln Lys Lys Ser His Leu Ala Asp 
        195                 200                 205             


Glu Ala Gly Tyr Val Thr Arg Leu Ala Arg Ile Cys Ile Thr Asp Pro 
    210                 215                 220                 


Asn Tyr Asp Ser Tyr Thr Glu Ile Thr Val Gln Cys Thr Ala Thr Glu 
225                 230                 235                 240 


Asn Asn Val Asp Tyr Asn Ile Val Arg Asp Ala Lys Val Thr Pro Ala 
                245                 250                 255     


Ser His Lys Leu Ala Gln Lys Met Gly Ile Lys Lys Asp Asp His Val 
            260                 265                 270         


Leu Val Thr Val Phe Ser Pro Ser Arg Glu Ile Ser Asn Gln Pro Glu 
        275                 280                 285             


Ser Lys Ser Ala Met Cys Ile Tyr Ser Ile Lys Asp Ile Glu Asp Met 
    290                 295                 300                 


Phe Ile Glu Asn Ile His Leu Cys Phe Asn Gly Thr Thr Lys Asp Arg 
305                 310                 315                 320 


Asn Leu Gly Tyr Ile Ser Gly Thr Ile Asn Asp Gly Arg Cys Pro Ile 
                325                 330                 335     


Val Gly Ser Leu Gly Asn Ile Tyr Asn Phe Cys Ser Val Gly Leu Lys 
            340                 345                 350         


Ile Ser Gly Val Ser Pro Ile Thr Ala His Ala Leu Phe His Phe Asp 
        355                 360                 365             


Asn Val Ser Val Thr Ser Val Thr Ala Thr Ser Thr Thr Asp Gln Gln 
    370                 375                 380                 


His Ser Leu Ala Phe Leu Gly Thr Asn Met Gly Val Ile Lys Lys Val 
385                 390                 395                 400 


Leu Leu Ser Gly Gln Ser Pro Gly Glu Tyr Glu Glu Ile Val Val Asp 
                405                 410                 415     


Ala Gly Asn Arg Ile Leu Pro Asn Thr Met Met Ser Pro Lys Lys 
            420                 425                 430     


<210>  43
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr Leu Gly 
1               5                   10                  15      


Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu Glu Ala 
            20                  25                  30          


Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu Pro Pro 
        35                  40                  45              


Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn Pro Asn 
    50                  55                  60                  


Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly Ser Val 
65                  70                  75                  80  


His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu Gln Leu 
                85                  90                  95      


Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala Ala Asn 
            100                 105                 110         


Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu Ala Gly 
        115                 120                 125             


Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly Val Gly 
    130                 135                 140                 


Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro Asp Pro 
145                 150                 155                 160 


Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val Gly Arg 
                165                 170                 175     


Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg Gly Ala 
            180                 185                 190         


Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln Ser Arg 
        195                 200                 205             


Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln His Tyr 
    210                 215                 220                 


Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg Tyr Gly 
225                 230                 235                 240 


Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala His Gly 
                245                 250                 255     


Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Ala Ala Gly 
            260                 265                 270         


Ala Ser Gly Ala Ser Ala Leu Cys Ala Phe Pro Leu Asp Glu Val Asp 
        275                 280                 285             


Arg Leu Ala Asn Arg Thr Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg 
    290                 295                 300                 


Ala Glu Asp Gly Thr Glu Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser 
305                 310                 315                 320 


Asp Cys Ala Gln Leu Pro Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly 
                325                 330                 335     


Ser Asp His Thr Pro Ser Pro Met Ala Ser Arg Val Pro Leu Glu Ala 
            340                 345                 350         


Thr Pro Ile Leu Glu Trp Pro Gly Ile Gln Leu Thr Ala Val Ala Val 
        355                 360                 365             


Thr Met Glu Asp Gly His Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly 
    370                 375                 380                 


Gln Leu His Arg Val Tyr Leu Gly Pro Gly Ser Asp Gly His Pro Tyr 
385                 390                 395                 400 


Ser Thr Gln Ser Ile Gln Gln Gly Ser Ala Val Ser Arg Asp Leu Thr 
                405                 410                 415     


Phe Asp Gly Thr Phe 
            420     


<210>  44
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu Gly 
1               5                   10                  15      


Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu Gln 
            20                  25                  30          


Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr Pro Pro 
        35                  40                  45              


Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val Asn 
    50                  55                  60                  


Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu Cys Gly 
65                  70                  75                  80  


Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn Ile Ser 
                85                  90                  95      


Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe Val Ala 
            100                 105                 110         


Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser Thr Gly 
        115                 120                 125             


Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly Asn Gly Pro His 
    130                 135                 140                 


Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp Arg Thr Asp Ser 
145                 150                 155                 160 


Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr Tyr Lys Ala Gly 
                165                 170                 175     


Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala Phe Glu Asp Gly 
            180                 185                 190         


Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys His Pro Ala Arg 
        195                 200                 205             


Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp Pro Asn Tyr Tyr 
    210                 215                 220                 


Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro Asp Ile His Ala 
225                 230                 235                 240 


Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala Ala Pro Gly Ser 
                245                 250                 255     


Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser Arg Ser Ser Gly 
            260                 265                 270         


Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp Lys Val His Ala 
        275                 280                 285             


Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly Thr Arg Glu Ala 
    290                 295                 300                 


Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile Gln Cys Gly Gly 
305                 310                 315                 320 


His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu His Leu 
                325                 330                 335     


Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala Val Leu 
            340                 345                 350         


Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu Asn 
        355                 360                 365             


Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile Leu Lys 
    370                 375                 380                 


Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr Asp Ser Ile Leu 
385                 390                 395                 400 


Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val Leu Ser Gly Asp 
                405                 410                 415     


Leu 
    


<210>  45
<211>  402
<212>  PRT
<213>  Mus musculus

<400>  45

Phe Asn His Leu Val Leu Ala Pro Asp Gln Gly Lys Leu Tyr Val Gly 
1               5                   10                  15      


Ala Val Asn His Leu Phe Gln Leu Ser Pro Glu Leu Lys Met Glu Ser 
            20                  25                  30          


Val Ala Val Thr Gly Pro Val Ile Asp Ser Pro Asp Cys Val Pro Phe 
        35                  40                  45              


Arg Asp Leu Ala Glu Cys Pro Gln Ala Gln Leu Thr Asp Asn Ala Asn 
    50                  55                  60                  


Gln Leu Leu Leu Val Ser Ser Arg Thr Gln Glu Leu Val Ala Cys Gly 
65                  70                  75                  80  


Gln Val Lys Gln Gly Val Cys Glu Lys Arg Arg Leu Gly Asp Val Thr 
                85                  90                  95      


Gln Val Leu Tyr Gln Ala Glu Asp Pro Gly Asp Gly Gln Phe Val Ala 
            100                 105                 110         


Ala Asn Thr Leu Gly Val Thr Thr Val Gly Leu Val Val Pro Leu Pro 
        115                 120                 125             


Gly Arg Asp Leu Leu Leu Val Ala Arg Gly Leu Ala Gly Lys Leu Ser 
    130                 135                 140                 


Ala Gly Val Pro Pro Leu Thr Val Arg Gln Leu Ala Gly Pro Gln Pro 
145                 150                 155                 160 


Phe Ser Ser Glu Gly Leu Gly Arg Leu Val Val Gly Asp Phe Ser Asp 
                165                 170                 175     


Tyr Asn Asn Ser Tyr Val Gly Ala Phe Ser Asp Ala His Ser Ala Tyr 
            180                 185                 190         


Phe Val Phe Arg Arg Arg Gly Ala Arg Ala Gln Thr Glu Tyr Arg Ser 
        195                 200                 205             


Tyr Val Ala Arg Val Cys Leu Arg Asp Val Asn Leu Tyr Ser Tyr Val 
    210                 215                 220                 


Glu Met Pro Leu Thr Cys His Gly Gln Gly Leu Ile Gln Ala Ala Phe 
225                 230                 235                 240 


Leu Thr Pro Asp Thr Leu Leu Gly Ala Phe Ser Ala Gly Thr Ser Gln 
                245                 250                 255     


Ala Gln Ala Ala Leu Cys Ala Phe Pro Leu Ala Asp Leu Asp Arg Ser 
            260                 265                 270         


Met Glu Gln Ala Arg Arg Leu Cys Tyr Thr Thr Gly Gly Gln Gly Pro 
        275                 280                 285             


Ser Gly Met Glu Glu Ala Thr Val Glu Tyr Gly Val Thr Ser Arg Cys 
    290                 295                 300                 


Val Thr Leu Pro Pro Asp Ser Pro Glu Ser Tyr Pro Cys Gly Asp Glu 
305                 310                 315                 320 


His Thr Pro Ser Pro Ile Ala Gly Arg Gln Pro Leu Glu Ala Gln Pro 
                325                 330                 335     


Leu Leu Gln Leu Gly Gln Ser Ile Ser Ala Val Ala Ala Leu Gln Thr 
            340                 345                 350         


Asp Gly His Thr Ile Ala Phe Leu Gly Asp Thr Gln Gly Gln Leu His 
        355                 360                 365             


Lys Val Phe Leu Asn Ser Ser His Gly Gln Val Tyr His Ser Gln Gln 
    370                 375                 380                 


Val Gly Pro Pro Gly Ser Ala Ile Ser Pro Asp Leu Leu Val Asp Ser 
385                 390                 395                 400 


Asn Gly 
        


<210>  46
<211>  437
<212>  PRT
<213>  Caenorhabditis elegans

<400>  46

Phe Glu Lys Met Ala Ile Asp Pro Ser Thr Thr Arg Val Phe Val Gly 
1               5                   10                  15      


Ala Val Asn Ser Leu Tyr Asp Leu Thr Ser Ala Asp Leu Thr Val Arg 
            20                  25                  30          


Arg His Val Gln Thr Gly Pro Gln Asp Asp Ser Pro Leu Cys Arg Gly 
        35                  40                  45              


Lys Trp Asn Lys Lys Asn Ser Leu Lys Lys Leu Tyr Ser Arg Thr Asn 
    50                  55                  60                  


Ser His Thr Lys Ala Leu Ser Val Tyr Asp Lys Ser Ser Lys Leu Ile 
65                  70                  75                  80  


Glu Cys Ser Asn Leu Tyr Gln Gly Arg Cys Arg Leu Arg Asn Leu His 
                85                  90                  95      


Asn Ile Ser Glu Val Ile Ser Glu Ala Ile Glu Pro Arg Val Ser Asn 
            100                 105                 110         


Asp Thr Ser Ser Ser Val Val Ile Phe Val Gly Ser Gly Pro Ala Asn 
        115                 120                 125             


Leu Ser Ser Glu Pro Val Leu Tyr Val Gly Ala Thr Ile Gly Ser Gly 
    130                 135                 140                 


Asp His Asp Arg Met Ser Val Ser Ser Leu Phe Leu Arg Pro Gln Lys 
145                 150                 155                 160 


Ala Phe Glu Val Val Phe Pro Gly Leu Tyr Gly Gly Thr His Val Ser 
                165                 170                 175     


Leu Asp Tyr Arg Ser Arg Gly Tyr Tyr Lys Tyr Gln Ile Asp Tyr Ile 
            180                 185                 190         


Asn Gly Phe Glu Ser Gly Asp Tyr Ala Tyr Phe Val Thr Arg Gln Arg 
        195                 200                 205             


Val Asn Ile Ala Asp Asp Ser Ser Ile Gln Ser Arg Leu Val Arg Val 
    210                 215                 220                 


Cys Thr Gly Asp Lys Asn Phe His Ser Tyr Thr Glu Val Pro Leu Glu 
225                 230                 235                 240 


Cys Thr Gln Asn Gly Val Glu Phe Asn Leu Val Gln Asp Val Tyr Val 
                245                 250                 255     


Thr Arg Ala Gly Tyr Glu Leu Ala Lys Ser Leu Asp Ile Ser Val Ser 
            260                 265                 270         


Asp Pro Val Leu Tyr Gly Val Phe Trp Glu Gly Asp Lys Asn Ser Tyr 
        275                 280                 285             


Arg Ser Gln Glu Pro Thr Gly Lys Ser Ala Ile Cys Met Phe Thr Met 
    290                 295                 300                 


Arg Glu Ile Glu Thr Ser Phe Lys Gln Asn Ile Met Lys Cys Tyr Lys 
305                 310                 315                 320 


Gly Thr Ser Gly Leu Lys Lys Asn Leu Pro Trp Phe Ser Ser Asn Asp 
                325                 330                 335     


Asp Cys Arg Phe Thr Thr Leu Pro Trp Glu Gly Ile Lys Cys Gly Lys 
            340                 345                 350         


Asp Val Asn Ser Lys Ile Gly Gly Asp Thr Pro Ile Ser Thr Ser Ala 
        355                 360                 365             


Thr Tyr Val Met Glu Asp Ser Ser Asn Leu Leu Thr Ala Ile Ala Ile 
    370                 375                 380                 


Asn Thr Thr Arg Ser Ser Thr Val Ala Phe Val Gly Thr Gln Gly Gly 
385                 390                 395                 400 


Gln Leu His Lys Ile Leu Ile Glu Ser Lys Arg Ser Ala Glu Lys Tyr 
                405                 410                 415     


Ala Thr Glu Met Leu Thr Asp Asn Glu Pro Ile Leu Ser Asp Met Glu 
            420                 425                 430         


Phe Gly Gly Asp Gly 
        435         


<210>  47
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  47

Thr Asn Asn Phe Ala Leu Asp Gly Ala Ala Gly Thr Val Tyr Leu Ala 
1               5                   10                  15      


Ala Val Asn Arg Leu Tyr Gln Leu Ser Gly Ala Asn Leu Ser Leu Glu 
            20                  25                  30          


Ala Glu Ala Ala Val Gly Pro Val Pro Asp Ser Pro Leu Cys His Ala 
        35                  40                  45              


Pro Gln Leu Pro Gln Ala Ser Cys Glu His Pro Arg Arg Leu Thr Asp 
    50                  55                  60                  


Asn Tyr Asn Lys Ile Leu Gln Leu Asp Pro Gly Gln Gly Leu Val Val 
65                  70                  75                  80  


Val Cys Gly Ser Ile Tyr Gln Gly Phe Cys Gln Leu Arg Arg Arg Gly 
                85                  90                  95      


Asn Ile Ser Ala Val Ala Val Arg Phe Pro Pro Ala Glu Pro Val Thr 
            100                 105                 110         


Val Phe Pro Ser Met Leu Asn Val Ala Ala Asn His Pro Asn Ala Ser 
        115                 120                 125             


Thr Val Gly Leu Val Leu Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg 
    130                 135                 140                 


Leu Leu Val Gly Ala Thr Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro 
145                 150                 155                 160 


Arg Asn Arg Ser Leu Glu Asp His Arg Phe Glu Asn Thr Pro Glu Ile 
                165                 170                 175     


Ala Ile Arg Ser Leu Asp Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr 
            180                 185                 190         


Phe Asp Leu Asn Pro Ser Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly 
        195                 200                 205             


Ala Lys Glu Gln His Lys Leu Gly Phe Val Ser Ala Phe Leu His Pro 
    210                 215                 220                 


Ser Asp Pro Pro Pro Gly Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn 
225                 230                 235                 240 


Ser Glu Ala Arg Ala Gly Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu 
                245                 250                 255     


Ala Arg Ile Cys Leu Pro His Gly Ala Gly Gly Asp Ala Lys Lys Leu 
            260                 265                 270         


Thr Glu Ser Tyr Ile Gln Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly 
        275                 280                 285             


Arg Gly Asp Leu Tyr Ser Arg Leu Val Ser Val Phe Pro Ala Arg Glu 
    290                 295                 300                 


Arg Leu Phe Ala Val Phe Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg 
305                 310                 315                 320 


Ala Ala Pro Ala Ala Leu Cys Ala Phe Arg Phe Ala Asp Val Arg Ala 
                325                 330                 335     


Ala Ile Arg Ala Ala Arg Thr Ala Cys Phe Val Glu Pro Ala Pro Asp 
            340                 345                 350         


Val Val Ala Val Leu Asp Ser Val Val Gln Gly Thr Gly Pro Ala Cys 
        355                 360                 365             


Glu Arg Lys Leu Asn Ile Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly 
    370                 375                 380                 


Ala Ala His Leu Gln His Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala 
385                 390                 395                 400 


Thr Pro Val Phe Arg Ala Pro Gly Leu Thr Ser Val Ala Val Ala Ser 
                405                 410                 415     


Val Asn Asn Tyr Thr Ala Val Phe Leu Gly Thr Val Asn Gly Arg Leu 
            420                 425                 430         


Leu Lys Ile Asn Leu Asn Glu Ser Met Gln Val Val Ser Arg Arg Val 
        435                 440                 445             


Val Thr Val Ala Tyr Gly Glu Pro Val His His Val Met Gln Phe Asp 
    450                 455                 460                 


Pro Ala Asp 
465         


<210>  48
<211>  390
<212>  PRT
<213>  Caenorhabditis elegans

<400>  48

Ile Asp Asp Phe Ile Val Ser Arg Asp Gln Gln Thr Ile Tyr Val Ala 
1               5                   10                  15      


Ser Leu Asn Arg Leu Thr Ser Leu Ser Ile Ser Asn Phe Ser Ile Gln 
            20                  25                  30          


His Glu Val Ser Leu Gly Pro Val Gln Asp Ser Pro Trp Cys Ser Ala 
        35                  40                  45              


Asp Gly Lys Ser Cys Leu Lys Leu Val Asn Phe Pro Thr Asp Val Arg 
    50                  55                  60                  


Thr Lys Ile Leu Gln Ile Leu Pro Thr Asn Gln Ile Leu Gln Cys Gly 
65                  70                  75                  80  


Ser Val Lys Leu Gly Ser Cys Ser Thr Phe Asn Ser Lys Leu Ser Leu 
                85                  90                  95      


Ile Thr Glu Ser Thr Ile Ala Val Ala Ala Asn Ser Pro Asp Ala Ser 
            100                 105                 110         


Thr Val Ser Lys Ile Ile Asp Asn Arg Leu Ile Val Ala Ala Ser Ala 
        115                 120                 125             


Thr Lys Glu Ser Pro Tyr Arg Asp Pro Phe Pro Ala Val Ala Ile Arg 
    130                 135                 140                 


Asn Leu Pro Gly Leu Asn Val Glu Asn Ala Gly Asp Leu Glu Gly Glu 
145                 150                 155                 160 


Ala Ala Val Phe Leu Arg Ala Ala Tyr Lys Asn Ala Phe Lys Phe Leu 
                165                 170                 175     


Tyr Thr Phe Thr His Gln His Phe Val Phe Val Val Ala Met Val Thr 
            180                 185                 190         


Pro Arg Glu Ser Arg Leu Pro Met Thr Thr Arg Leu Ile Arg Phe Cys 
        195                 200                 205             


Arg Asn Asp Thr Lys Phe Glu Ser Tyr Ser Glu Ile Glu Leu Gln Cys 
    210                 215                 220                 


Arg Gly Glu Asp Asn Thr Asn Tyr Pro Phe Leu Asn Ala Ile Ile Gln 
225                 230                 235                 240 


Ser Tyr Asp Lys Leu Ile Ala Ser Phe Ser Thr Ser Ser Thr Ser Pro 
                245                 250                 255     


Lys Ser Ser Ile Cys Val Phe Ser Met Gln Lys Val Lys Leu Thr Phe 
            260                 265                 270         


Trp Tyr Asn Val Asp Arg Cys Arg Ser Gly Thr Asp Ser Ile Arg Leu 
        275                 280                 285             


Pro His Ile Gly Arg Asp Thr Lys Cys Lys Ala His Ile Pro Leu Asp 
    290                 295                 300                 


Glu Asp Ser Cys Glu Leu Gly Val Gly Gly Ser Ile Glu Leu Val Glu 
305                 310                 315                 320 


Met Ser Thr Lys Asp Ile Met Gly Lys Val Thr Ser Leu Met Ala Val 
                325                 330                 335     


Asp Gln Lys Ala Ile Phe Ala Gly Thr Thr Thr Ser Gln Ile Val Met 
            340                 345                 350         


Phe Lys Trp Asp Glu His His Ser Asn Gln Leu Glu Glu Tyr Gly Arg 
        355                 360                 365             


Lys Glu Val Gly Asp Gly Arg Thr Gly Ser Glu Val Ser Lys Met Val 
    370                 375                 380                 


Lys Phe Gly Asp Phe Val 
385                 390 


<210>  49
<211>  391
<212>  PRT
<213>  Vaccinia virus

<400>  49

Leu Leu Phe Ile Leu Phe Tyr Phe Ala Asn Gly Ile Glu Trp His Lys 
1               5                   10                  15      


Phe Glu Thr Ser Glu Glu Ile Ile Ser Thr Tyr Leu Leu Asp Asp Val 
            20                  25                  30          


Leu Tyr Thr Gly Val Asn Gly Ala Val Tyr Thr Phe Ser Asn Asn Lys 
        35                  40                  45              


Leu Asn Lys Thr Gly Leu Thr Asn Asn Asn Tyr Ile Thr Thr Ser Ile 
    50                  55                  60                  


Lys Val Glu Asp Ala Asp Lys Asp Thr Leu Val Cys Gly Thr Asn Asn 
65                  70                  75                  80  


Gly Asn Pro Lys Cys Trp Lys Ile Asp Gly Ser Asp Asp Pro Lys His 
                85                  90                  95      


Arg Gly Arg Gly Tyr Ala Pro Tyr Gln Asn Ser Lys Val Thr Ile Ile 
            100                 105                 110         


Ser His Asn Gly Cys Val Leu Ser Asp Ile Asn Ile Ser Lys Glu Gly 
        115                 120                 125             


Ile Lys Arg Trp Arg Arg Phe Asp Gly Pro Cys Gly Tyr Asp Leu Tyr 
    130                 135                 140                 


Thr Ala Asp Asn Val Ile Pro Lys Asp Gly Leu Arg Gly Ala Phe Val 
145                 150                 155                 160 


Asp Lys Asp Gly Thr Tyr Asp Lys Val Tyr Ile Leu Phe Thr Asp Thr 
                165                 170                 175     


Ile Gly Ser Lys Arg Ile Val Lys Ile Pro Tyr Ile Ala Gln Met Cys 
            180                 185                 190         


Leu Asn Asp Glu Gly Gly Pro Ser Ser Leu Ser Ser His Arg Trp Ser 
        195                 200                 205             


Thr Phe Leu Lys Val Glu Leu Glu Cys Asp Ile Asp Gly Arg Ser Tyr 
    210                 215                 220                 


Arg Gln Ile Ile His Ser Arg Thr Ile Lys Thr Asp Asn Asp Thr Ile 
225                 230                 235                 240 


Leu Tyr Val Phe Phe Asp Ser Pro Tyr Ser Lys Ser Ala Leu Cys Thr 
                245                 250                 255     


Tyr Ser Met Asn Thr Ile Lys Gln Ser Phe Ser Thr Ser Lys Leu Glu 
            260                 265                 270         


Gly Tyr Thr Lys Gln Leu Pro Ser Pro Ala Ser Gly Ile Cys Leu Pro 
        275                 280                 285             


Ala Gly Lys Val Val Pro His Thr Thr Phe Glu Val Ile Glu Lys Tyr 
    290                 295                 300                 


Asn Val Leu Asp Asp Ile Ile Lys Pro Leu Ser Asn Gln Pro Ile Phe 
305                 310                 315                 320 


Glu Gly Pro Ser Gly Val Lys Trp Phe Asp Ile Lys Glu Lys Glu Asn 
                325                 330                 335     


Glu His Arg Glu Tyr Arg Ile Tyr Phe Ile Lys Glu Asn Ser Ile Tyr 
            340                 345                 350         


Ser Phe Asp Thr Lys Ser Lys Gln Thr Arg Ser Ser Gln Val Asp Ala 
        355                 360                 365             


Arg Leu Phe Ser Val Met Val Thr Ser Lys Pro Leu Phe Ile Ala Asp 
    370                 375                 380                 


Ile Gly Ile Gly Val Gly Met 
385                 390     


<210>  50
<211>  398
<212>  PRT
<213>  Caenorhabditis elegans

<400>  50

Leu Val Ile Leu His Lys Leu Pro Gly Glu Tyr Val Leu Leu Gly Gly 
1               5                   10                  15      


Arg Asn His Val Tyr Asn Ile Ser Ile Ser Ser Met Leu Glu Ile Ala 
            20                  25                  30          


Arg Tyr Glu Trp Thr Ser Ser Asp Glu Ala Arg Thr Asn Cys Ala Ala 
        35                  40                  45              


Ile Ser Gln Thr Pro Ala Ser Cys Glu Asn Phe Ile Arg Thr Tyr Phe 
    50                  55                  60                  


Glu Leu Thr Asn Asp Thr Leu Ile Leu Cys Gly Thr His Ala Leu Gln 
65                  70                  75                  80  


Pro Thr Cys Ala Glu Phe Arg Lys Gly Asn Ala Lys Pro Gln Arg Leu 
                85                  90                  95      


Ile Ser Ala Val Gly Met Ser Pro Ile Asp Ala Asp Ser Thr Ala Pro 
            100                 105                 110         


Phe Ile Arg Ser Asn Glu Asn Ile Ile Thr Val Asn Val Ala Glu Leu 
        115                 120                 125             


Ser Ser Ser Glu Pro Leu Leu Val Arg Arg Asn Val Ile Lys Met Trp 
    130                 135                 140                 


Lys Gly Ile Glu Asn Asp Val Ile Leu Arg Thr Pro Arg Gly Leu Ser 
145                 150                 155                 160 


Ser Phe Glu Gln Ala Asn Phe Leu Ser Met His Lys Val Lys Lys Val 
                165                 170                 175     


Arg Gly Val Glu Glu Val Leu Phe Phe Phe Ser Glu Ser Pro Met Glu 
            180                 185                 190         


Thr Glu Gly Cys Gly Leu His Lys Val Ala Arg Val Gly Arg Val Cys 
        195                 200                 205             


Glu Asp Asp Pro Gly Gly Arg Leu Ser Tyr Asn Lys Glu Trp Ser Ser 
    210                 215                 220                 


Tyr Glu Lys Ala Arg Ile Glu Cys Ser Ile Glu Glu Thr Asp Thr Asp 
225                 230                 235                 240 


Thr Phe Tyr Phe Asn Gln Phe Ala Gly Val Ala Glu Ser Pro Thr Ser 
                245                 250                 255     


Phe Tyr Gly Ala Phe Arg Ser Gln Leu Ala Gly Ile Gly Ala Ser Ala 
            260                 265                 270         


Ile Cys Lys Tyr Ser Lys Lys Val Ile Ser Gly Ser Phe Ala Ser Gly 
        275                 280                 285             


Tyr Lys Glu Ser Thr Pro Asp Thr Cys Ser Arg Ala Asn Asp Ile Glu 
    290                 295                 300                 


Glu Leu Ser Arg Ile Arg Leu Lys Pro Leu Ile Lys Gln Lys Ile Ser 
305                 310                 315                 320 


Ala Asn Pro Ile Tyr Ile Phe His Gly Lys Asp Arg Phe Val His Val 
                325                 330                 335     


Leu Ala Gln Glu Asp Thr Arg Asp Leu Ser Asn Arg Ala Tyr Asp Ile 
            340                 345                 350         


Leu Tyr Val Ala Thr Asn Leu Gly Asn Ile Leu Lys Ile Val Val Pro 
        355                 360                 365             


Ser Thr Asp Lys Thr Gly Arg His Ala Val Thr Leu Lys Val Leu Pro 
    370                 375                 380                 


Thr Asn Ser Lys Ile Val Asp Met Ser Leu Tyr Ser Lys Asn 
385                 390                 395             


<210>  51
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  51

His Thr Val Leu Phe His Glu Pro Gly Ser Ser Ser Val Trp Val Gly 
1               5                   10                  15      


Gly Arg Gly Lys Val Tyr Leu Phe Asp Phe Pro Glu Gly Lys Asn Ala 
            20                  25                  30          


Ser Val Arg Thr Val Asn Ile Gly Ser Thr Lys Gly Ser Cys Leu Asp 
        35                  40                  45              


Lys Arg Asp Cys Glu Asn Tyr Ile Thr Leu Leu Glu Arg Arg Ser Glu 
    50                  55                  60                  


Gly Leu Leu Ala Cys Gly Thr Asn Ala Arg His Pro Ser Cys Trp Asn 
65                  70                  75                  80  


Leu Val Asn Gly Thr Val Val Pro Leu Gly Glu Met Arg Gly Tyr Ala 
                85                  90                  95      


Pro Phe Ser Pro Asp Glu Asn Ser Leu Val Leu Phe Glu Gly Arg Ala 
            100                 105                 110         


Gly Asp Glu Val Tyr Ser Thr Ile Arg Lys Gln Glu Tyr Asn Gly Lys 
        115                 120                 125             


Ile Arg Arg Phe Arg Arg Ile Arg Gly Glu Ser Glu Leu Tyr Thr Ser 
    130                 135                 140                 


Asp Thr Val Met Gln Asn Pro Gln Phe Ile Lys Ala Thr Ile Val His 
145                 150                 155                 160 


Gln Asp Gln Ala Tyr Asp Asp Lys Ile Tyr Tyr Phe Phe Arg Glu Asp 
                165                 170                 175     


Asn Pro Asp Lys Asn Pro Glu Ala Pro Leu Asn Val Ser Arg Val Ala 
            180                 185                 190         


Gln Leu Cys Arg Gly Asp Gln Gly Gly Glu Ser Ser Leu Ser Val Ser 
        195                 200                 205             


Lys Trp Asn Thr Phe Leu Lys Ala Met Leu Val Cys Ser Asp Ala Ala 
    210                 215                 220                 


Thr Asn Lys Asn Phe Asn Arg Leu Gln Asp Val Phe Leu Leu Pro Asp 
225                 230                 235                 240 


Pro Ser Gly Gln Trp Arg Asp Thr Arg Val Tyr Gly Val Phe Ser Asn 
                245                 250                 255     


Pro Trp Asn Tyr Ser Ala Val Cys Val Tyr Ser Leu Gly Asp Ile Asp 
            260                 265                 270         


Lys Val Phe Arg Thr Ser Ser Leu Lys Gly Tyr His Ser Ser Leu Pro 
        275                 280                 285             


Asn Pro Arg Pro Gly Lys Cys Leu Pro Asp Gln Gln Pro Ile Pro Thr 
    290                 295                 300                 


Glu Thr Phe Gln Val Ala Asp Arg His Pro Glu Val Ala Gln Arg Val 
305                 310                 315                 320 


Glu Pro Met Gly Pro Leu Lys Thr Pro Leu Phe His Ser Lys Tyr His 
                325                 330                 335     


Tyr Gln Lys Val Ala Val His Arg Met Gln Ala Ser His Gly Glu Thr 
            340                 345                 350         


Phe His Val Leu Tyr Leu Thr Thr Asp Arg Gly Thr Ile His Lys Val 
        355                 360                 365             


Val Glu Pro Gly Glu Gln Glu His Ser Phe Ala Phe Asn Ile Met Glu 
    370                 375                 380                 


Ile Gln Pro Phe Arg Arg Ala Ala Ala Ile Gln Thr Met Ser Leu Asp 
385                 390                 395                 400 


Ala Glu Arg 
            


<210>  52
<211>  400
<212>  PRT
<213>  Alcelaphine herpesvirus 1

<400>  52

His Thr Val Leu Phe His Ser Leu Asn Ser Ser Asp Val Tyr Val Gly 
1               5                   10                  15      


Gly Asn Asn Thr Ile Tyr Leu Phe Asp Phe Ala His Ser Ser Asn Ala 
            20                  25                  30          


Ser Thr Ala Leu Ile Asn Ile Thr Ser Thr His Asn Thr His Arg Leu 
        35                  40                  45              


Ser Ser Thr Cys Glu Asn Phe Ile Thr Leu Leu His Asn Gln Thr Asp 
    50                  55                  60                  


Gly Leu Leu Ala Cys Gly Thr Asn Ser Gln Lys Pro Ser Cys Trp Leu 
65                  70                  75                  80  


Ile Asn Asn Leu Thr Thr Gln Phe Leu Gly Pro Lys Leu Gly Leu Ala 
                85                  90                  95      


Pro Phe Ser Pro Ser Ser Gly Asn Leu Val Leu Phe Asp Gln Asn Asp 
            100                 105                 110         


Thr Tyr Ser Thr Ile Asn Leu Tyr Lys Ser Leu Ser Gly Ser His Lys 
        115                 120                 125             


Phe Arg Arg Ile Ala Gly Gln Val Glu Leu Tyr Thr Ser Asp Thr Ala 
    130                 135                 140                 


Met His Arg Pro Gln Phe Val Gln Ala Thr Ala Val His Lys Asn Glu 
145                 150                 155                 160 


Ser Tyr Asp Asp Lys Ile Tyr Phe Phe Phe Gln Glu Asn Ser His Ser 
                165                 170                 175     


Asp Phe Lys Gln Phe Pro His Thr Val Pro Arg Val Gly Gln Val Cys 
            180                 185                 190         


Ser Ser Asp Gln Gly Gly Glu Ser Ser Leu Ser Val Tyr Lys Trp Thr 
        195                 200                 205             


Thr Phe Leu Lys Ala Arg Leu Ala Cys Val Asp Tyr Asp Thr Gly Arg 
    210                 215                 220                 


Ile Tyr Asn Glu Leu Gln Asp Ile Phe Ile Trp Gln Ala Pro Glu Asn 
225                 230                 235                 240 


Ser Trp Glu Glu Thr Leu Ile Tyr Gly Leu Phe Leu Ser Pro Trp Asn 
                245                 250                 255     


Phe Ser Ala Val Cys Val Phe Thr Val Lys Asp Ile Asp His Val Phe 
            260                 265                 270         


Lys Thr Ser Lys Leu Lys Asn Tyr His His Lys Leu Pro Thr Pro Arg 
        275                 280                 285             


Pro Gly Gln Cys Met Lys Asn His Gln His Val Pro Thr Glu Thr Phe 
    290                 295                 300                 


Gln Val Ala Asp Arg Tyr Pro Glu Val Ala Asp Pro Val Tyr Gln Lys 
305                 310                 315                 320 


Asn Asn Ala Met Phe Pro Ile Ile Gln Ser Lys Tyr Ile Tyr Thr Lys 
                325                 330                 335     


Leu Leu Val Tyr Arg Val Glu Tyr Gly Gly Val Phe Trp Ala Thr Ile 
            340                 345                 350         


Phe Tyr Leu Thr Thr Ile Lys Gly Thr Ile His Ile Tyr Val Arg Tyr 
        355                 360                 365             


Glu Asp Ser Asn Ser Thr Thr Ala Leu Asn Ile Leu Glu Ile Asn Pro 
    370                 375                 380                 


Phe Gln Lys Pro Ala Pro Ile Gln Asn Ile Leu Leu Asp Asn Thr Asn 
385                 390                 395                 400 


<210>  53
<211>  370
<212>  PRT
<213>  Fowlpox virus

<400>  53

Val Val Ile Tyr Arg Thr Asp Cys Asn Thr Arg Leu Ile Ile Gly Val 
1               5                   10                  15      


Thr Asn Thr Val Tyr Val Val Asn Thr Thr Asp Lys Ser Asn Ile Thr 
            20                  25                  30          


Val Asp Phe Ser Pro Asp Asn Val Ser Thr Gln Ser Gly Ala Asn Tyr 
        35                  40                  45              


Ile Thr Phe Ile Gly Gly Tyr Asp Asp Lys Ile Leu Val Cys Gly Thr 
    50                  55                  60                  


Asn Ser Ser Ser Pro Thr Cys Trp Tyr Ile Asn Gly Thr Ile Lys Glu 
65                  70                  75                  80  


Pro Thr Pro Tyr Gly Arg Gly Leu Ser Pro Glu Ser Tyr Asp Met Thr 
                85                  90                  95      


Gly Leu Val Leu Ile Asp Gly Lys Glu Ile Tyr Ser Thr Ile Lys Lys 
            100                 105                 110         


Tyr Ser His Leu Ser Thr Gly Phe Ser Arg Ile Val Gly Lys Pro Val 
        115                 120                 125             


Leu Tyr Thr Ser Ser Ser Thr Met Lys Asn Pro Lys Phe Val His Leu 
    130                 135                 140                 


Val Ser Leu Gln Glu Thr Asn Ser Ile Asn Asp Thr Ile Tyr Ile Phe 
145                 150                 155                 160 


Phe Gln Glu Glu Gly Met Ala Lys Val Ser Arg Val Cys Lys His Asp 
                165                 170                 175     


Gln Gly Gly Ser Gly Ser Leu Ser Gly Ser Lys Trp Ser Thr Phe Leu 
            180                 185                 190         


Lys Ser Ile Met Ile Cys Glu Asp Leu Asn Val Arg Phe Asn Tyr Leu 
        195                 200                 205             


Lys Asp Val Val Val Ile Lys Gly Lys Ser Pro Asn Glu Thr Ile Ile 
    210                 215                 220                 


Tyr Gly Leu Phe Phe Asn Glu Trp Asn Tyr Ser Ala Val Cys Met Phe 
225                 230                 235                 240 


Lys Phe Asp Lys Ile Gln Asn Asn Phe Asn Thr Ser Pro Leu Lys Gly 
                245                 250                 255     


Tyr Ser Gly Gly Lys Val Leu Ser Val Arg Pro Gly Thr Cys Leu Asn 
            260                 265                 270         


Thr Ser Thr Pro Arg Asp Thr Phe Glu Val Ile Asp Leu Tyr Pro Glu 
        275                 280                 285             


Thr Leu Tyr Gly Val Lys Gly Asp Phe Ile Phe Lys Thr Lys Tyr Thr 
    290                 295                 300                 


Tyr Thr His Ile Val Ile Asn Thr Ala Val Ile Asn Tyr Gln His Lys 
305                 310                 315                 320 


Asp Tyr Arg Val Thr Thr Phe Tyr Leu Ser Thr Ser Asp Gly Lys Ile 
                325                 330                 335     


His Lys Val Val Val Tyr Glu Asp Gly Val Ile Asn Val Ile Glu Leu 
            340                 345                 350         


Thr Leu Lys Gln Tyr Pro Ser Pro Val Leu Ala Leu Val Ser Asp Glu 
        355                 360                 365             


Arg Ser 
    370 


<210>  54
<211>  422
<212>  PRT
<213>  Caenorhabditis elegans

<400>  54

Phe Arg Glu Leu Leu Ile Asp Pro Lys Ala Gly Ala Leu Phe Val Gly 
1               5                   10                  15      


Ser Glu Gly Ala Ile Phe Arg Leu Trp Ala Tyr Asn Ile Asn Asp Thr 
            20                  25                  30          


Gly Glu Asn Val Phe Ala Lys Lys Gln Leu Val Leu Ser Glu Ser Glu 
        35                  40                  45              


Glu Ser Glu Tyr Arg Ser Thr Ala Ser Asp Glu Arg Leu Cys Arg Pro 
    50                  55                  60                  


Ser Thr Arg Phe Leu Ala Phe Thr Asn Asn Leu Asp Ser Ile Tyr Val 
65                  70                  75                  80  


Cys Ser Ser Val Gly Met Arg Pro Glu Ile Arg Val Leu Asp Ser Leu 
                85                  90                  95      


Ser Leu Arg Asp Gln Gln Glu Pro Arg Thr Glu Ile Gly Ile Cys Val 
            100                 105                 110         


Val Asp Pro Thr Phe Asn Phe Thr Ala Val Val Val Asp Ser Asp Ala 
        115                 120                 125             


Thr Ser Val Tyr Ser Gly Ile Arg Thr Gly Met Gly Gly Glu Asn His 
    130                 135                 140                 


Leu Ile Tyr Arg Pro Pro Leu Thr Lys Asn Gly Lys Gln Leu His Ala 
145                 150                 155                 160 


Ser Ile Arg Thr Ile Tyr Ser Asp Asn Lys Trp Leu Asn Glu Pro Gln 
                165                 170                 175     


Phe Val Gly Ser Phe Asp Val Gly Gln His Val Phe Phe Phe Phe Arg 
            180                 185                 190         


Glu Ile Ala His Asp Asn Ser Phe Gly Glu Arg Ile Val His Ser Arg 
        195                 200                 205             


Val Ala Arg Val Cys Lys Lys Asp Ile Gly Gly Arg Asn Val Leu Arg 
    210                 215                 220                 


Gln Val Trp Thr Ser Phe Val Lys Ala Arg Leu Asn Cys Ser Val Ser 
225                 230                 235                 240 


Ala Asn Phe Pro Phe Tyr Phe Asp His Ile Gln Ser Val Lys Arg Val 
                245                 250                 255     


Asp Lys His Gly Glu Thr Tyr Phe Tyr Ala Thr Phe Ser Thr Ser Glu 
            260                 265                 270         


Thr Ala Phe Thr Ser Ser Ala Ile Cys Met Phe Gln Leu Ser Ser Ile 
        275                 280                 285             


Asn His Leu Leu Asp Thr Gly Leu Leu Met Glu Glu Thr Ala Asn Gly 
    290                 295                 300                 


Gln Phe Ser Val Thr Ala Asp Glu Ile Pro Ala His Arg Pro Gly Thr 
305                 310                 315                 320 


Cys Ser Gln Asn Ser His Ser Ile Ser Asp Thr Asp Leu His Phe Ala 
                325                 330                 335     


Lys Thr His Leu Leu Val Ser Asp Ser Ile Ser Gly Gly Thr Pro Ile 
            340                 345                 350         


Leu Pro Leu Arg Asp His Val Phe Thr His Ile Val Val Asp Gln Leu 
        355                 360                 365             


Pro Asn Gln Asn Val Ile Phe Ala Phe Asp Ser Ala Asn Arg Arg Val 
    370                 375                 380                 


Trp Lys Ile Ser His Trp Lys Glu Gly Asn Glu Trp Lys Ser Asn Leu 
385                 390                 395                 400 


Ile Glu Glu Lys Ser Leu Lys Ile Ala Ala Ser Arg Ile Asn Asp Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Glu 
            420         


<210>  55
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Asp Ile Gln Met Ile Met Ile Met Asn Gly Thr Leu Tyr Ile Ala 
1               5                   10                  15      


Ala Arg Asp His Ile Tyr Thr Val Asp Ile Asp Thr Ser His Thr Glu 
            20                  25                  30          


Glu Ile Tyr Cys Ser Lys Lys Leu Thr Trp Lys Ser Arg Gln Ala Asp 
        35                  40                  45              


Val Asp Thr Cys Arg Met Lys Gly Lys His Lys Asp Glu Cys His Asn 
    50                  55                  60                  


Phe Ile Lys Val Leu Leu Lys Lys Asn Asp Asp Ala Leu Phe Val Cys 
65                  70                  75                  80  


Gly Thr Asn Ala Phe Asn Pro Ser Cys Arg Asn Tyr Lys Met Asp Thr 
                85                  90                  95      


Leu Glu Pro Phe Gly Asp Glu Phe Ser Gly Met Ala Arg Cys Pro Tyr 
            100                 105                 110         


Asp Ala Lys His Ala Asn Val Ala Leu Phe Ala Asp Gly Lys Leu Tyr 
        115                 120                 125             


Ser Ala Thr Val Thr Asp Phe Leu Ala Ile Asp Ala Val Ile Tyr Arg 
    130                 135                 140                 


Ser Leu Gly Glu Ser Pro Thr Leu Arg Thr Val Lys His Asp Ser Lys 
145                 150                 155                 160 


Trp Leu Lys Glu Pro Tyr Phe Val Gln Ala Val Asp Tyr Gly Asp Tyr 
                165                 170                 175     


Ile Tyr Phe Phe Phe Arg Glu Ile Ala Val Glu Tyr Asn Thr Met Gly 
            180                 185                 190         


Lys Val Val Phe Pro Arg Val Ala Gln Val Cys Lys Asn Asp Met Gly 
        195                 200                 205             


Gly Ser Gln Arg Val Leu Glu Lys Gln Trp Thr Ser Phe Leu Lys Ala 
    210                 215                 220                 


Arg Leu Asn Cys Ser Val Pro Gly Asp Ser His Phe Tyr Phe Asn Ile 
225                 230                 235                 240 


Leu Gln Ala Val Thr Asp Val Ile Arg Ile Asn Gly Arg Asp Val Val 
                245                 250                 255     


Leu Ala Thr Phe Ser Thr Pro Tyr Asn Ser Ile Pro Gly Ser Ala Val 
            260                 265                 270         


Cys Ala Tyr Asp Met Leu Asp Ile Ala Ser Val Phe Thr Gly Arg Phe 
        275                 280                 285             


Lys Glu Gln Lys Ser Pro Asp Ser Thr Trp Thr Pro Val Pro Asp Glu 
    290                 295                 300                 


Arg Val Pro Lys Pro Arg Pro Gly Cys Cys Ala Gly Ser Ser Ser Leu 
305                 310                 315                 320 


Glu Arg Tyr Ala Thr Ser Asn Glu Phe Pro Asp Asp Thr Leu Asn Phe 
                325                 330                 335     


Ile Lys Thr His Pro Leu Met Asp Glu Ala Val Pro Ser Ile Phe Asn 
            340                 345                 350         


Arg Pro Trp Phe Leu Arg Thr Met Val Arg Tyr Arg Leu Thr Lys Ile 
        355                 360                 365             


Ala Val Asp Thr Ala Ala Gly Pro Tyr Gln Asn His Thr Val Val Phe 
    370                 375                 380                 


Leu Gly Ser Glu Lys Gly Ile Ile Leu Lys Phe Leu Ala Arg Ile Gly 
385                 390                 395                 400 


Asn Ser Gly Phe Leu Asn Asp Ser Leu Phe Leu Glu Glu Met Ser Val 
                405                 410                 415     


Tyr Asn Ser Glu Lys Cys Ser Tyr Asp Gly Val Glu Asp Lys Arg Ile 
            420                 425                 430         


<210>  56
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Asn Ile Gln Arg Val Leu Arg Val Asn Arg Thr Leu Phe Ile Gly 
1               5                   10                  15      


Asp Arg Asp Asn Leu Tyr Arg Val Glu Leu Glu Pro Pro Thr Ser Thr 
            20                  25                  30          


Glu Leu Arg Tyr Gln Arg Lys Leu Thr Trp Arg Ser Asn Pro Ser Asp 
        35                  40                  45              


Ile Asn Val Cys Arg Met Lys Gly Lys Gln Glu Gly Glu Cys Arg Asn 
    50                  55                  60                  


Phe Val Lys Val Leu Leu Leu Arg Asp Glu Ser Thr Leu Phe Val Cys 
65                  70                  75                  80  


Gly Ser Asn Ala Phe Asn Pro Val Cys Ala Asn Tyr Ser Ile Asp Thr 
                85                  90                  95      


Leu Gln Pro Val Gly Asp Asn Ile Ser Gly Met Ala Arg Cys Pro Tyr 
            100                 105                 110         


Asp Pro Lys His Ala Asn Val Ala Leu Phe Ser Asp Gly Met Leu Phe 
        115                 120                 125             


Thr Ala Thr Val Thr Asp Phe Leu Ala Ile Asp Ala Val Ile Tyr Arg 
    130                 135                 140                 


Ser Leu Gly Asp Arg Pro Thr Leu Arg Thr Val Lys His Asp Ser Lys 
145                 150                 155                 160 


Trp Phe Lys Glu Pro Tyr Phe Val His Ala Val Glu Trp Gly Ser His 
                165                 170                 175     


Val Tyr Phe Phe Phe Arg Glu Ile Ala Met Glu Phe Asn Tyr Leu Glu 
            180                 185                 190         


Lys Val Val Val Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly 
        195                 200                 205             


Gly Ser Pro Arg Val Leu Glu Lys Gln Trp Thr Ser Phe Leu Lys Ala 
    210                 215                 220                 


Arg Leu Asn Cys Ser Val Pro Gly Asp Ser His Phe Tyr Phe Asn Val 
225                 230                 235                 240 


Leu Gln Ala Val Thr Gly Val Val Ser Leu Gly Gly Arg Pro Val Val 
                245                 250                 255     


Leu Ala Val Phe Ser Thr Pro Ser Asn Ser Ile Pro Gly Ser Ala Val 
            260                 265                 270         


Cys Ala Phe Asp Leu Thr Gln Val Ala Ala Val Phe Glu Gly Arg Phe 
        275                 280                 285             


Arg Glu Gln Lys Ser Pro Glu Ser Ile Trp Thr Pro Val Pro Glu Asp 
    290                 295                 300                 


Gln Val Pro Arg Pro Arg Pro Gly Cys Cys Ala Ala Pro Gly Met Gln 
305                 310                 315                 320 


Tyr Asn Ala Ser Ser Ala Leu Pro Asp Asp Ile Leu Asn Phe Val Lys 
                325                 330                 335     


Thr His Pro Leu Met Asp Glu Ala Val Pro Ser Leu Gly His Ala Pro 
            340                 345                 350         


Trp Ile Leu Arg Thr Leu Met Arg His Gln Leu Thr Arg Val Ala Val 
        355                 360                 365             


Asp Val Gly Ala Gly Pro Trp Gly Asn Gln Thr Val Val Phe Leu Gly 
    370                 375                 380                 


Ser Glu Ala Gly Thr Val Leu Lys Phe Leu Val Arg Pro Asn Ala Ser 
385                 390                 395                 400 


Thr Ser Gly Thr Ser Gly Leu Ser Val Phe Leu Glu Glu Phe Glu Thr 
                405                 410                 415     


Tyr Arg Pro Asp Arg Cys Gly Arg Pro Gly Gly Gly Glu Thr Gly Gln 
            420                 425                 430         


<210>  57
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  57

Leu Asp Phe Gln Arg Phe Leu Thr Leu Asn Arg Thr Leu Leu Val Ala 
1               5                   10                  15      


Ala Arg Asp His Val Phe Ser Phe Asp Leu Gln Ala Glu Glu Glu Gly 
            20                  25                  30          


Glu Gly Leu Val Pro Asn Lys Tyr Leu Thr Trp Arg Ser Gln Asp Val 
        35                  40                  45              


Glu Asn Cys Ala Val Arg Gly Lys Leu Thr Asp Glu Cys Tyr Asn Tyr 
    50                  55                  60                  


Ile Arg Val Leu Val Pro Trp Asp Ser Gln Thr Leu Leu Ala Cys Gly 
65                  70                  75                  80  


Thr Asn Ser Phe Ser Pro Val Cys Arg Ser Tyr Gly Ile Thr Ser Leu 
                85                  90                  95      


Gln Gln Glu Gly Glu Glu Leu Ser Gly Gln Ala Arg Cys Pro Phe Asp 
            100                 105                 110         


Ala Thr Gln Ser Asn Val Ala Ile Phe Ala Glu Gly Ser Leu Tyr Ser 
        115                 120                 125             


Ala Thr Ala Ala Asp Phe Gln Ala Ser Asp Ala Val Val Tyr Arg Ser 
    130                 135                 140                 


Leu Gly Pro Gln Pro Pro Leu Arg Ser Ala Lys Tyr Asp Ser Lys Trp 
145                 150                 155                 160 


Leu Arg Glu Pro His Phe Val Gln Ala Leu Glu His Gly Asp His Val 
                165                 170                 175     


Tyr Phe Phe Phe Arg Glu Val Ser Val Glu Asp Ala Arg Leu Gly Lys 
            180                 185                 190         


Val Gln Phe Ser Arg Val Ala Arg Val Cys Lys Arg Asp Met Gly Gly 
        195                 200                 205             


Ser Pro Arg Ala Leu Asp Arg His Trp Thr Ser Phe Leu Lys Leu Arg 
    210                 215                 220                 


Leu Asn Cys Ser Val Pro Gly Asp Ser Thr Phe Tyr Phe Asp Val Leu 
225                 230                 235                 240 


Gln Ala Leu Thr Gly Pro Val Asn Leu His Gly Arg Ser Ala Leu Phe 
                245                 250                 255     


Gly Val Phe Thr Thr Gln Thr Asn Ser Ile Pro Gly Ser Ala Val Cys 
            260                 265                 270         


Ala Phe Tyr Leu Asp Glu Ile Glu Arg Gly Phe Glu Gly Lys Phe Lys 
        275                 280                 285             


Glu Gln Arg Ser Leu Asp Gly Ala Trp Thr Pro Val Ser Glu Asp Arg 
    290                 295                 300                 


Val Pro Ser Pro Arg Pro Gly Ser Cys Ala Gly Val Gly Gly Ala Ala 
305                 310                 315                 320 


Leu Phe Ser Ser Ser Arg Asp Leu Pro Asp Asp Val Leu Thr Phe Ile 
                325                 330                 335     


Lys Ala His Pro Leu Leu Asp Pro Ala Val Pro Pro Val Thr His Gln 
            340                 345                 350         


Pro Leu Leu Thr Leu Thr Ser Arg Ala Leu Leu Thr Gln Val Ala Val 
        355                 360                 365             


Asp Gly Met Ala Gly Pro His Ser Asn Ile Thr Val Met Phe Leu Gly 
    370                 375                 380                 


Ser Asn Asp Gly Thr Val Leu Lys Val Leu Thr Pro Gly Gly Arg Ser 
385                 390                 395                 400 


Gly Gly Pro Glu Pro Ile Leu Leu Glu Glu Ile Asp Ala Tyr Ser Pro 
                405                 410                 415     


Ala Arg Cys Ser Gly Lys Arg Thr Ala Gln Thr Ala Arg 
            420                 425                 


<210>  58
<211>  435
<212>  PRT
<213>  Schistocerca gregaria

<400>  58

Tyr Arg Thr Phe His Leu Asp Glu Lys Arg Glu Ser Leu Tyr Val Gly 
1               5                   10                  15      


Ala Leu Asp Lys Val Tyr Lys Leu Asn Leu Thr Asn Ile Ser Leu Ser 
            20                  25                  30          


Asp Cys Glu Arg Asp Ser Leu Thr Leu Glu Pro Thr Asn Ile Ala Asn 
        35                  40                  45              


Cys Val Ser Lys Gly Lys Ser Ala Asp Phe Asp Cys Lys Asn His Ile 
    50                  55                  60                  


Arg Val Ile Gln Pro Met Gly Asp Gly Ser Arg Leu Tyr Ile Cys Gly 
65                  70                  75                  80  


Thr Asn Ala His Ser Pro Lys Asp Trp Val Val Tyr Ser Asn Leu Thr 
                85                  90                  95      


His Leu Gln Arg His Glu Tyr Val Pro Gly Ile Gly Val Gly Ile Ala 
            100                 105                 110         


Lys Cys Pro Phe Asp Pro Glu Asp Ser Ser Thr Ala Val Trp Val Glu 
        115                 120                 125             


Asn Asp Leu Pro Gly Leu Tyr Ser Gly Thr Asn Ala Glu Phe Thr Lys 
    130                 135                 140                 


Ala Asp Thr Val Ile Phe Arg Thr Asp Leu Tyr Asn Leu Thr Thr Gly 
145                 150                 155                 160 


Arg Arg Glu Tyr Ser Phe Lys Arg Thr Leu Lys Tyr Asp Ser Lys Trp 
                165                 170                 175     


Leu Asp Asn Pro Asn Phe Val Gly Ser Phe Asp Val Gly Glu Tyr Val 
            180                 185                 190         


Leu Phe Phe Phe Arg Glu Thr Ala Val Glu Tyr Ile Asn Cys Gly Lys 
        195                 200                 205             


Ser Val Tyr Ser Arg Val Ala Arg Val Cys Lys Lys Asp Val Gly Gly 
    210                 215                 220                 


Lys Asn Ile Leu Ser Gln Asn Trp Ala Thr Phe Leu Lys Ala Arg Leu 
225                 230                 235                 240 


Asn Cys Ser Ile Pro Gly Glu Phe Pro Phe Tyr Phe Asn Glu Ile Gln 
                245                 250                 255     


Gly Val Tyr Lys Met Pro Asn Thr Asp Lys Phe Phe Gly Val Phe Ser 
            260                 265                 270         


Thr Ser Val Thr Gly Leu Thr Gly Ser Ala Ile Cys Ser Phe Thr Leu 
        275                 280                 285             


Lys Asp Ile Gln Glu Val Phe Ser Gly Lys Phe Lys Glu Gln Ala Thr 
    290                 295                 300                 


Ser Ser Ser Ala Trp Leu Pro Val Leu Pro Ser Arg Val Pro Asp Pro 
305                 310                 315                 320 


Arg Pro Gly Glu Cys Val Asn Asp Thr Glu Leu Leu Pro Asp Thr Val 
                325                 330                 335     


Leu Asn Phe Ile Arg Ser His Pro Leu Met Asp Gly Ala Val Ser His 
            340                 345                 350         


Glu Gly Gly Lys Pro Val Phe Tyr Lys Arg Asp Val Leu Phe Thr Gln 
        355                 360                 365             


Leu Val Val Asp Lys Leu Lys Val Asn Leu Val Gly Lys Asn Met Glu 
    370                 375                 380                 


Tyr Ile Val Tyr Tyr Ala Gly Thr Ser Thr Gly Gln Val Tyr Lys Val 
385                 390                 395                 400 


Val Gln Trp Tyr Asp Ser Gly Gly Leu Pro Gln Ser Leu Leu Val Asp 
                405                 410                 415     


Ile Phe Asp Val Thr Pro Pro Glu Pro Val Gln Ala Leu His Leu Ser 
            420                 425                 430         


Lys Glu Tyr 
        435 


<210>  59
<211>  435
<212>  PRT
<213>  Drosophila melanogaster

<400>  59

Tyr Arg Thr Phe His Met Asn Glu Asp Arg Asp Thr Leu Tyr Val Gly 
1               5                   10                  15      


Ala Met Asp Arg Val Phe Arg Val Asn Leu Gln Asn Ile Ser Ser Ser 
            20                  25                  30          


Asn Cys Asn Arg Asp Ala Ile Asn Leu Glu Pro Thr Arg Asp Asp Val 
        35                  40                  45              


Val Ser Cys Val Ser Lys Gly Lys Ser Gln Ile Phe Asp Cys Lys Asn 
    50                  55                  60                  


His Val Arg Val Ile Gln Ser Met Asp Gln Gly Asp Arg Leu Tyr Val 
65                  70                  75                  80  


Cys Gly Thr Asn Ala His Asn Pro Lys Asp Tyr Val Ile Tyr Ala Asn 
                85                  90                  95      


Leu Thr His Leu Pro Arg Ser Glu Tyr Val Ile Gly Val Gly Leu Gly 
            100                 105                 110         


Ile Ala Lys Cys Pro Tyr Asp Pro Leu Asp Asn Ser Thr Ala Ile Tyr 
        115                 120                 125             


Val Glu Asn Gly Leu Pro Gly Leu Tyr Ser Gly Thr Asn Ala Glu Phe 
    130                 135                 140                 


Thr Lys Ala Asp Thr Val Ile Phe Arg Thr Asp Leu Tyr Asn Thr Ser 
145                 150                 155                 160 


Ala Lys Arg Leu Glu Tyr Lys Phe Lys Arg Thr Leu Lys Tyr Asp Ser 
                165                 170                 175     


Lys Trp Leu Asp Lys Pro Asn Phe Val Gly Ser Phe Asp Ile Gly Glu 
            180                 185                 190         


Tyr Val Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Tyr Ile Asn Cys 
        195                 200                 205             


Gly Lys Ala Val Tyr Ser Arg Ile Ala Arg Val Cys Lys Lys Asp Val 
    210                 215                 220                 


Gly Gly Lys Asn Leu Leu Ala His Asn Trp Ala Thr Tyr Leu Lys Ala 
225                 230                 235                 240 


Arg Leu Asn Cys Ser Ile Ser Gly Glu Phe Pro Phe Tyr Phe Asn Glu 
                245                 250                 255     


Ile Gln Ser Val Tyr Gln Leu Pro Ser Asp Lys Ser Arg Phe Phe Ala 
            260                 265                 270         


Thr Phe Thr Thr Ser Thr Asn Gly Leu Ile Gly Ser Ala Val Cys Ser 
        275                 280                 285             


Phe His Ile Asn Glu Ile Gln Ala Ala Phe Asn Gly Lys Phe Lys Glu 
    290                 295                 300                 


Gln Ser Ser Ser Asn Ser Ala Trp Leu Pro Val Leu Asn Ser Arg Val 
305                 310                 315                 320 


Pro Glu Pro Arg Pro Gly Thr Cys Val Asn Asp Thr Ser Asn Leu Pro 
                325                 330                 335     


Asp Thr Val Leu Asn Phe Ile Arg Ser His Pro Leu Met Asp Lys Ala 
            340                 345                 350         


Val Asn His Glu His Asn Asn Pro Val Tyr Tyr Lys Arg Asp Leu Val 
        355                 360                 365             


Phe Thr Lys Leu Val Val Asp Lys Ile Arg Ile Asp Ile Leu Asn Gln 
    370                 375                 380                 


Glu Tyr Ile Val Tyr Tyr Val Gly Thr Asn Leu Gly Arg Ile Tyr Lys 
385                 390                 395                 400 


Ile Val Gln Tyr Tyr Arg Asn Gly Glu Ser Leu Ser Lys Leu Leu Asp 
                405                 410                 415     


Ile Phe Glu Val Ala Pro Asn Glu Ala Ile Gln Val Met Glu Ile Ser 
            420                 425                 430         


Gln Thr Arg 
        435 


<210>  60
<211>  422
<212>  PRT
<213>  Schistocerca americana

<400>  60

His Phe Lys Leu Leu Glu Lys Asp His Asn Ser Leu Leu Val Gly Ala 
1               5                   10                  15      


Arg Asn Ile Val Tyr Asn Ile Ser Leu Arg Asp Leu Thr Glu Phe Thr 
            20                  25                  30          


Glu Gln Arg Ile Glu Trp His Ser Ser Gly Ala His Arg Glu Leu Cys 
        35                  40                  45              


Tyr Leu Lys Gly Lys Ser Glu Asp Asp Cys Gln Asn Tyr Ile Arg Val 
    50                  55                  60                  


Leu Ala Lys Ile Asp Asp Asp Arg Val Leu Ile Cys Gly Thr Asn Ala 
65                  70                  75                  80  


Tyr Lys Pro Leu Cys Arg His Tyr Ala Leu Lys Asp Gly Asp Tyr Val 
                85                  90                  95      


Val Glu Lys Glu Tyr Glu Gly Arg Gly Leu Cys Pro Phe Asp Pro Asp 
            100                 105                 110         


His Asn Ser Thr Ala Ile Tyr Ser Glu Gly Gln Leu Tyr Ser Ala Thr 
        115                 120                 125             


Val Ala Asp Phe Ser Gly Thr Asp Pro Leu Ile Tyr Arg Gly Pro Leu 
    130                 135                 140                 


Arg Thr Glu Arg Ser Asp Leu Lys Gln Leu Asn Ala Pro Asn Phe Val 
145                 150                 155                 160 


Asn Thr Met Glu Tyr Asn Asp Phe Ile Phe Phe Phe Phe Arg Glu Thr 
                165                 170                 175     


Ala Val Glu Tyr Ile Asn Cys Gly Lys Ala Ile Tyr Ser Arg Val Ala 
            180                 185                 190         


Arg Val Cys Lys His Asp Lys Gly Gly Pro His Gln Phe Gly Asp Arg 
        195                 200                 205             


Trp Thr Ser Phe Leu Lys Ser Arg Leu Asn Cys Ser Val Pro Gly Asp 
    210                 215                 220                 


Tyr Pro Phe Tyr Phe Asn Glu Ile Gln Ser Thr Ser Asp Ile Ile Glu 
225                 230                 235                 240 


Gly Asn Tyr Gly Gly Gln Val Glu Lys Leu Ile Tyr Gly Val Phe Thr 
                245                 250                 255     


Thr Pro Val Asn Ser Ile Gly Gly Ser Ala Val Cys Ala Phe Ser Met 
            260                 265                 270         


Lys Ser Ile Leu Glu Ser Phe Asp Gly Pro Phe Lys Glu Gln Glu Thr 
        275                 280                 285             


Met Asn Ser Asn Trp Leu Ala Val Pro Ser Leu Lys Val Pro Glu Pro 
    290                 295                 300                 


Arg Pro Gly Gln Cys Val Asn Asp Ser Arg Thr Leu Pro Asp Val Ser 
305                 310                 315                 320 


Val Asn Phe Val Lys Ser His Thr Leu Met Asp Glu Ala Val Pro Ala 
                325                 330                 335     


Phe Phe Thr Arg Pro Ile Leu Ile Arg Ile Ser Leu Gln Tyr Arg Phe 
            340                 345                 350         


Thr Lys Ile Ala Val Asp Gln Gln Val Arg Thr Pro Asp Gly Lys Ala 
        355                 360                 365             


Tyr Asp Val Leu Phe Ile Gly Thr Asp Asp Gly Lys Val Ile Lys Ala 
    370                 375                 380                 


Leu Asn Ser Ala Ser Phe Asp Ser Ser Asp Thr Val Asp Ser Val Val 
385                 390                 395                 400 


Ile Glu Glu Leu Gln Val Leu Pro Pro Gly Val Pro Val Lys Asn Leu 
                405                 410                 415     


Tyr Val Val Arg Met Asp 
            420         


<210>  61
<211>  420
<212>  PRT
<213>  Tribolium confusum

<400>  61

His Phe Ile Val Leu Asn Gln Asp Glu Thr Ser Ile Leu Val Gly Gly 
1               5                   10                  15      


Arg Asn Arg Val Tyr Asn Leu Ser Ile Phe Asp Leu Ser Glu Arg Lys 
            20                  25                  30          


Gly Gly Arg Ile Asp Trp Pro Ser Ser Asp Ala His Gly Gln Leu Cys 
        35                  40                  45              


Ile Leu Lys Gly Lys Thr Asp Asp Asp Cys Gln Asn Tyr Ile Arg Ile 
    50                  55                  60                  


Leu Tyr Ser Ser Glu Pro Gly Lys Leu Val Ile Cys Gly Thr Asn Ser 
65                  70                  75                  80  


Tyr Lys Pro Leu Cys Arg Thr Tyr Ala Phe Lys Glu Gly Lys Tyr Leu 
                85                  90                  95      


Val Glu Lys Glu Val Glu Gly Ile Gly Leu Cys Pro Tyr Asn Pro Glu 
            100                 105                 110         


His Asn Ser Thr Ser Val Ser Tyr Asn Gly Gln Leu Phe Ser Ala Thr 
        115                 120                 125             


Val Ala Asp Phe Ser Gly Gly Asp Pro Leu Ile Tyr Arg Glu Pro Gln 
    130                 135                 140                 


Arg Thr Glu Leu Ser Asp Leu Lys Gln Leu Asn Ala Pro Asn Phe Val 
145                 150                 155                 160 


Asn Ser Val Ala Tyr Gly Asp Tyr Ile Phe Phe Phe Tyr Arg Glu Thr 
                165                 170                 175     


Ala Val Glu Tyr Met Asn Cys Gly Lys Val Ile Tyr Ser Arg Val Ala 
            180                 185                 190         


Arg Val Cys Lys Asp Asp Lys Gly Gly Pro His Gln Ser Arg Asp Arg 
        195                 200                 205             


Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Ile Pro Gly Glu 
    210                 215                 220                 


Tyr Pro Phe Tyr Phe Asp Glu Ile Gln Ser Thr Ser Asp Ile Val Glu 
225                 230                 235                 240 


Gly Arg Tyr Asn Ser Asp Asp Ser Lys Lys Ile Ile Tyr Gly Ile Leu 
                245                 250                 255     


Thr Thr Pro Val Asn Ala Ile Gly Gly Ser Ala Ile Cys Ala Tyr Gln 
            260                 265                 270         


Met Ala Asp Ile Leu Arg Val Phe Glu Gly Ser Phe Lys His Gln Glu 
        275                 280                 285             


Thr Ile Asn Ser Asn Trp Leu Pro Val Pro Gln Asn Leu Val Pro Glu 
    290                 295                 300                 


Pro Arg Pro Gly Gln Cys Val Arg Asp Ser Arg Ile Leu Pro Asp Lys 
305                 310                 315                 320 


Asn Val Asn Phe Ile Lys Thr His Ser Leu Met Glu Asp Val Pro Ala 
                325                 330                 335     


Leu Phe Gly Lys Pro Val Leu Val Arg Val Ser Leu Gln Tyr Arg Phe 
            340                 345                 350         


Thr Ala Ile Thr Val Asp Pro Gln Val Lys Thr Ile Asn Asn Gln Tyr 
        355                 360                 365             


Leu Asp Val Leu Tyr Ile Gly Thr Asp Asp Gly Lys Val Leu Lys Ala 
    370                 375                 380                 


Val Asn Ile Pro Lys Arg His Ala Lys Ala Leu Leu Tyr Arg Lys Tyr 
385                 390                 395                 400 


Arg Thr Ser Val His Pro His Gly Ala Pro Val Lys Gln Leu Lys Ile 
                405                 410                 415     


Ala Pro Gly Tyr 
            420 


<210>  62
<211>  420
<212>  PRT
<213>  Drosophila melanogaster

<400>  62

His Phe Lys Leu Val Thr Lys Asp Gly Asn Ser Leu Leu Ile Gly Ala 
1               5                   10                  15      


Arg Asn Thr Val Phe Asn Leu Ser Ile His Asp Leu Val Glu Gln Gln 
            20                  25                  30          


Arg Leu Val Trp Thr Ser Pro Glu Asp Asp Thr Lys Met Cys Leu Val 
        35                  40                  45              


Lys Gly Lys Asp Glu Glu Ala Cys Gln Asn Tyr Ile Arg Ile Met Val 
    50                  55                  60                  


Val Pro Ser Pro Gly Arg Leu Phe Val Cys Gly Thr Asn Ser Phe Arg 
65                  70                  75                  80  


Pro Met Cys Asn Thr Tyr Ile Ile Ser Asp Ser Asn Tyr Thr Leu Glu 
                85                  90                  95      


Ala Thr Lys Asn Gly Gln Ala Val Cys Pro Tyr Asp Pro Arg His Asn 
            100                 105                 110         


Ser Thr Ser Val Leu Ala Asp Asn Glu Leu Tyr Ser Gly Thr Val Ala 
        115                 120                 125             


Asp Phe Ser Gly Ser Asp Pro Ile Ile Tyr Arg Glu Pro Leu Gln Thr 
    130                 135                 140                 


Glu Gln Tyr Asp Ser Leu Ser Leu Asn Ala Pro Asn Phe Val Ser Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Phe Val Tyr Phe Phe Phe Arg Glu Thr Ala Val 
                165                 170                 175     


Glu Phe Ile Asn Cys Gly Lys Ala Ile Tyr Ser Arg Val Ala Arg Val 
            180                 185                 190         


Cys Lys Trp Asp Lys Gly Gly Pro His Arg Phe Arg Asn Arg Trp Thr 
        195                 200                 205             


Ser Phe Leu Lys Ser Arg Leu Asn Cys Ser Ile Pro Gly Asp Tyr Pro 
    210                 215                 220                 


Phe Tyr Phe Asn Glu Ile Gln Ser Ala Ser Asn Leu Val Glu Gly Gln 
225                 230                 235                 240 


Tyr Gly Ser Met Ser Ser Lys Leu Ile Tyr Gly Val Phe Asn Thr Pro 
                245                 250                 255     


Ser Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Ala Leu Gln Asp 
            260                 265                 270         


Ile Ala Asp Thr Phe Glu Gly Gln Phe Lys Glu Gln Thr Gly Ile Asn 
        275                 280                 285             


Ser Asn Trp Leu Pro Val Asn Asn Ala Lys Val Pro Asp Pro Arg Pro 
    290                 295                 300                 


Gly Ser Cys His Asn Asp Ser Arg Ala Leu Pro Asp Pro Thr Leu Asn 
305                 310                 315                 320 


Phe Ile Lys Thr His Ser Leu Met Asp Glu Asn Val Pro Ala Phe Phe 
                325                 330                 335     


Ser Gln Pro Ile Leu Val Arg Thr Ser Thr Ile Tyr Arg Phe Thr Gln 
            340                 345                 350         


Ile Ala Val Asp Ala Gln Ile Lys Thr Pro Gly Gly Lys Thr Tyr Asp 
        355                 360                 365             


Val Ile Phe Val Gly Thr Asp His Gly Lys Ile Ile Lys Ser Val Asn 
    370                 375                 380                 


Ala Glu Ser Ala Asp Ser Ala Asp Lys Val Thr Ser Val Val Ile Glu 
385                 390                 395                 400 


Glu Ile Asp Val Leu Thr Lys Ser Glu Pro Ile Arg Asn Leu Glu Ile 
                405                 410                 415     


Val Arg Thr Met 
            420 


<210>  63
<211>  428
<212>  PRT
<213>  Drosophila melanogaster

<400>  63

Phe Lys Ile Leu Asp His Asn Asp Glu Phe Val Leu Val Gly Ala Lys 
1               5                   10                  15      


Asp Val Ile Tyr Asn Val Ser Leu Asn Gly Leu Lys Glu Ile Ala Arg 
            20                  25                  30          


Leu Glu Trp His Ser Thr Asp Ala Asp Arg Glu Leu Cys Ala Leu Lys 
        35                  40                  45              


Gly Lys His Glu Trp Asp Cys His Asn Tyr Leu Arg Val Tyr Ala Leu 
    50                  55                  60                  


Arg Pro Asn Gly Glu Val Leu Leu Cys Gly Thr Asn Ser Tyr Lys Pro 
65                  70                  75                  80  


Arg Cys Arg His Tyr Thr Ala Val Glu Val Ser Ser Glu Glu Ala Gly 
                85                  90                  95      


Ser Ala Gly His Ala His Ala Met Arg Tyr Glu Val Ser Arg Asp Val 
            100                 105                 110         


Glu Ala Gln Gly Leu Cys Pro Tyr Ser Pro Ala His Asn Ser Thr Tyr 
        115                 120                 125             


Ala Phe Ala Asp Gly His Leu Tyr Ser Ala Thr Val Ala Asp Phe Ser 
    130                 135                 140                 


Gly Gly Asp Pro Leu Ile Tyr Arg Glu Asn Leu Arg Thr Glu Gln Tyr 
145                 150                 155                 160 


Asp Leu Lys Gln Leu Asn Gln Pro Asp Phe Val Gly Ala Ile Glu Arg 
                165                 170                 175     


Asn Gly Tyr Val Leu Phe Phe Phe Arg Glu Leu Ser Met Glu Val Met 
            180                 185                 190         


Asn Phe Gly Lys Ala Val Tyr Ser Arg Val Ala Arg Val Cys Lys Asn 
        195                 200                 205             


Asp Arg Gly Gly Pro Tyr Ser His Gly Lys Ser Trp Thr Ser Phe Leu 
    210                 215                 220                 


Lys Ala Arg Leu Asn Cys Ser Val Pro Gly Glu Phe Pro Phe Tyr Phe 
225                 230                 235                 240 


Asp Glu Ile Gln Ala Ile Ser Pro Ile Val Glu Ser Gly Ser Lys Ser 
                245                 250                 255     


Leu Ile Tyr Ala Val Phe Thr Thr Ser Val Asn Ala Ile Pro Gly Ser 
            260                 265                 270         


Ala Val Cys Ala Phe Asn Val Asp Asp Ile Leu Ala Ala Phe Asp Gly 
        275                 280                 285             


Glu Phe Lys Ser Gln Lys Asp Ser Gln Ser His Trp Leu Pro Val Glu 
    290                 295                 300                 


Arg Glu Gln Val Pro Lys Pro Arg Pro Gly Gln Cys Val Glu Asp Ser 
305                 310                 315                 320 


Arg Thr Leu Thr Ser Ile Ala Val Asn Phe Ile Lys Asn His Pro Leu 
                325                 330                 335     


Met Glu Glu Ala Val Pro Ala Val His Gly Arg Pro Leu Leu Thr Lys 
            340                 345                 350         


Val Asn Leu His His Arg Leu Thr Ala Ile Ala Val His Pro Gln Val 
        355                 360                 365             


Lys Ser Leu Ser Gly Ala Tyr Tyr Asp Val Ile Tyr Ser Gly Thr Asp 
    370                 375                 380                 


Asp Gly Lys Val Thr Lys Phe Ile Asn Ile Leu Ser Thr His Pro Asn 
385                 390                 395                 400 


Arg Leu Lys Thr Val Val Ile Ser Glu Met Gln Val Leu Pro Leu Gly 
                405                 410                 415     


Thr Pro Ile Arg Glu Leu Val Ile Ser Thr Ser Lys 
            420                 425             


<210>  64
<211>  427
<212>  PRT
<213>  Caenorhabditis elegans

<400>  64

His Phe Lys Leu Leu Ala Ala Asp Gly Asp Ser Leu Leu Val Gly Ala 
1               5                   10                  15      


Arg Asn Ala Val Tyr Asn Leu Ser Leu Ser Thr Leu Ser Val Asn His 
            20                  25                  30          


Lys Ile Asp Trp Lys Pro Pro Ala Glu His Ile Glu Glu Cys Ile Met 
        35                  40                  45              


Lys Gly Lys Ser Lys Thr Asp Cys Gln Asn Tyr Ile Arg Val Leu Ala 
    50                  55                  60                  


Arg Lys Ser Ala Gly Val Ser Leu Val Cys Gly Thr His Ala Phe Ser 
65                  70                  75                  80  


Pro Lys Cys Arg Glu Tyr Thr Val Thr Glu Phe Gly Ile Arg Asn Thr 
                85                  90                  95      


Arg Gln Phe Asp Gly Gln Gly Ile Ser Pro Tyr Asp Pro Lys His Asn 
            100                 105                 110         


Ser Ser Ala Leu Tyr Val Pro Gly Thr Asn Gln Leu Phe Val Ala Thr 
        115                 120                 125             


Val Thr Asp Phe Val Gly Asn Asp Ala Leu Ile Tyr Arg Lys Thr Ile 
    130                 135                 140                 


Asp Glu Thr Pro Ser Ser Lys Ser Ala Ala Asn Ile Arg Thr Gln Ser 
145                 150                 155                 160 


Tyr Asp Ala Arg Val Leu Asn Ala Pro Asn Phe Val Ala Thr Phe Ala 
                165                 170                 175     


Tyr Lys Glu His Val Tyr Phe Trp Phe Arg Glu Ile Ala Ser Glu Ala 
            180                 185                 190         


Ile Asp Asn Asn Glu Glu Pro Gln Ile Tyr Ala Arg Val Ala Arg Val 
        195                 200                 205             


Cys Lys Asn Asp Lys Gly Gly Ala Arg Pro Ala Asn Glu Arg Trp Thr 
    210                 215                 220                 


Ser Tyr Leu Lys Ala Arg Leu Asn Cys Ser Leu Pro Ser Gly Ser Ser 
225                 230                 235                 240 


Pro Phe Tyr Phe Asn Glu Leu Lys Ala Val Ser Asp Pro Ile Asp Ala 
                245                 250                 255     


Gly Asn Asn Asn His Val Val Tyr Thr Val Phe Ser Thr Pro Asp Ser 
            260                 265                 270         


Asp Val Arg Met Ser Ala Val Cys Lys Phe Ser Met Lys Lys Ile Arg 
        275                 280                 285             


Glu Glu Phe Asp Asn Gly Thr Phe Lys His Gln Asn Asn Ala Gln Ser 
    290                 295                 300                 


Met Trp Met Ala Phe Asn Arg Asn Glu Val Pro Lys Pro Arg Pro Gly 
305                 310                 315                 320 


Ser Cys Ser Pro Asp Ser Thr Lys Leu Pro Glu Asn Thr Val Ser Phe 
                325                 330                 335     


Ile Leu His His Pro Leu Leu His Arg Pro Ile Pro Ser Val Ala Ala 
            340                 345                 350         


Pro Leu Leu Val Glu Gly Ala Asp Arg Ala Asp Leu Thr Gln Ile Thr 
        355                 360                 365             


Val Leu Pro Arg Val Arg Ala Val Gly Gly His Asn Tyr Asp Ile Leu 
    370                 375                 380                 


Phe Ile Gly Thr Ser Asp Gly Lys Val Leu Lys Val Val Glu Val Asp 
385                 390                 395                 400 


Gly Asn Ala Thr Val Ile Gln Ser Ala Thr Val Phe Gln Arg Gly Val 
                405                 410                 415     


Pro Ile Val Asn Leu Leu Thr Thr Lys Glu Ser 
            420                 425         


<210>  65
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  65

Phe Ser Gln Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile Val Gly 
1               5                   10                  15      


Ala Arg Asn Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Ser Leu Leu 
            20                  25                  30          


Gln Ala Thr Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Ser Cys Gln 
        35                  40                  45              


Ser Lys Gly Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Arg Val Leu 
    50                  55                  60                  


Ile Val Ala Gly Arg Lys Val Phe Met Cys Gly Thr Asn Ala Phe Ser 
65                  70                  75                  80  


Pro Met Cys Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Thr Thr Glu 
                85                  90                  95      


Lys Ile Asn Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg His Asn Ser 
            100                 105                 110         


Thr Ala Val Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Thr Val Ile 
        115                 120                 125             


Asp Phe Ser Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly Ser Gly 
    130                 135                 140                 


Pro Pro Leu Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro 
145                 150                 155                 160 


Asn Phe Val Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Phe Phe Leu 
                165                 170                 175     


Arg Glu Asn Ala Val Glu His Asp Cys Gly Arg Thr Val Tyr Ser Arg 
            180                 185                 190         


Val Ala Arg Val Cys Lys Asn Asp Val Gly Gly Arg Phe Leu Leu Glu 
        195                 200                 205             


Asp Thr Trp Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser Arg Pro 
    210                 215                 220                 


Gly Glu Val Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Phe His Leu 
225                 230                 235                 240 


Pro Glu Gln Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Val Asn Ser 
                245                 250                 255     


Ile Ala Ala Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Ile Ser Gln 
            260                 265                 270         


Ala Phe Asn Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Ala Ala Trp 
        275                 280                 285             


Leu Pro Ile Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Thr Leu Pro 
    290                 295                 300                 


Glu Thr Gly Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gln Asp Ala 
305                 310                 315                 320 


Gln Arg Leu Phe Leu Met Ser Glu Ala Val Gln Pro Val Thr Pro Glu 
                325                 330                 335     


Pro Cys Val Thr Gln Asp Ser Val Arg Phe Ser His Leu Val Val Asp 
            340                 345                 350         


Leu Val Gln Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Ile Gly Thr 
        355                 360                 365             


Glu Ser Gly Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Arg Ser Leu 
    370                 375                 380                 


His Gly Cys Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gly Arg Arg 
385                 390                 395                 400 


Glu Pro Leu Arg Ser Leu Arg Ile Leu His Ser Ala 
                405                 410         


<210>  66
<211>  411
<212>  PRT
<213>  Mus musculus

<400>  66

Phe Ser Arg Leu Thr Phe Asp Pro Gly Gln Lys Glu Leu Val Val Gly 
1               5                   10                  15      


Ala Arg Asn Tyr Leu Phe Arg Leu Glu Leu Glu Asp Leu Ser Leu Ile 
            20                  25                  30          


Gln Ala Val Glu Trp Glu Cys Asp Glu Ala Thr Lys Lys Ala Cys Tyr 
        35                  40                  45              


Ser Lys Gly Lys Ser Lys Glu Glu Cys Gln Asn Tyr Ile Arg Val Leu 
    50                  55                  60                  


Leu Val Gly Gly Asp Arg Leu Phe Thr Cys Gly Thr Asn Ala Phe Thr 
65                  70                  75                  80  


Pro Val Cys Thr Ile Arg Ser Leu Ser Asn Leu Thr Glu Ile His Asp 
                85                  90                  95      


Gln Ile Ser Gly Met Ala Arg Cys Pro Tyr Ser Pro Gln His Asn Ser 
            100                 105                 110         


Thr Ala Leu Leu Thr Ala Ser Gly Glu Leu Tyr Ala Ala Thr Ala Met 
        115                 120                 125             


Asp Phe Pro Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly Thr Leu 
    130                 135                 140                 


Pro Pro Leu Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro 
145                 150                 155                 160 


Asn Phe Val Ser Ser Tyr Asp Ile Gly Asn Phe Thr Tyr Phe Phe Phe 
                165                 170                 175     


Arg Glu Asn Ala Val Glu His Asp Cys Gly Lys Thr Val Phe Ser Arg 
            180                 185                 190         


Pro Ala Arg Val Cys Lys Asn Asp Ile Gly Gly Arg Phe Leu Leu Glu 
        195                 200                 205             


Asp Thr Trp Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser Arg Pro 
    210                 215                 220                 


Gly Glu Val Pro Phe Tyr Tyr Asn Glu Leu Gln Gly Thr Phe Phe Leu 
225                 230                 235                 240 


Pro Glu Leu Asp Leu Ile Tyr Gly Ile Phe Thr Thr Asn Val Asn Ser 
                245                 250                 255     


Ile Ala Ser Ser Ala Val Cys Val Phe Asn Leu Ser Ala Ile Ser Gln 
            260                 265                 270         


Ala Phe Asn Gly Pro Phe Lys Tyr Gln Glu Asn Ser Arg Ser Ala Trp 
        275                 280                 285             


Leu Pro Tyr Pro Asn Pro Asn Pro Asn Phe Gln Cys Gly Thr Met Asp 
    290                 295                 300                 


Gln Gly Leu Tyr Val Asn Leu Thr Glu Arg Asn Leu Gln Asp Ala Gln 
305                 310                 315                 320 


Lys Phe Ile Leu Met His Glu Val Val Gln Pro Val Thr Thr Val Pro 
                325                 330                 335     


Ser Phe Met Glu Asp Asn Ser Arg Phe Ser His Leu Ala Val Asp Val 
            340                 345                 350         


Val Gln Gly Arg Glu Thr Leu Val His Ile Ile Tyr Leu Gly Thr Asp 
        355                 360                 365             


Tyr Gly Thr Ile Lys Lys Val Arg Ala Pro Leu Ser Gln Ser Ser Gly 
    370                 375                 380                 


Ser Cys Leu Leu Glu Glu Ile Glu Leu Phe Pro Glu Arg Arg Ser Glu 
385                 390                 395                 400 


Pro Ile Arg Ser Leu Gln Ile Leu His Ser Gln 
                405                 410     


<210>  67
<211>  407
<212>  PRT
<213>  Drosophila melanogaster

<400>  67

Tyr Ser Glu Met Leu Phe Asp Val Ala Arg Asn Gln Val Ile Val Gly 
1               5                   10                  15      


Ala Arg Asp Thr Leu Tyr Arg Met Ser Phe Asp Leu Glu Pro Leu Glu 
            20                  25                  30          


Arg Ala Ser Trp Gly Ala Thr Pro Ser Glu Ile Ala Met Cys Gln Ala 
        35                  40                  45              


Lys Gly Gln Ser Glu Arg Trp Cys Arg Asn Tyr Val Arg Val Leu His 
    50                  55                  60                  


Ser Tyr Gly Glu Asn Gln Leu Tyr Ala Cys Gly Thr Asn Ala Phe Gln 
65                  70                  75                  80  


Pro Ser Cys Ser Trp Arg Gln Met Glu Asn Leu Thr Val Thr Gly Val 
                85                  90                  95      


Asp Ser Gly Val Val Lys Cys Pro Phe His Pro Gln Ala Asn Ser Thr 
            100                 105                 110         


Ser Leu Leu Gln Ser Asn Gly Gln Leu Phe Val Gly Thr Ala Thr Asp 
        115                 120                 125             


Phe Ser Gly Ser Asp Val Ala Ile Leu Arg Thr Gly Val Glu Ser Asn 
    130                 135                 140                 


Lys Arg Phe Leu Arg Thr Lys Gln Tyr Asn Asn Asn Trp Leu Ser Gly 
145                 150                 155                 160 


Ala Gln Phe Val Gly Ser Phe Glu Ala Gly His Phe Val Tyr Phe Leu 
                165                 170                 175     


Leu Arg Glu Ser Ala Ala Glu His Met Ser Cys Gly Lys Val Ile Tyr 
            180                 185                 190         


Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly Gly Gly Gly Gln 
        195                 200                 205             


Leu Leu Arg Asp Asn Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys 
    210                 215                 220                 


Ser Leu Pro Gly Glu Tyr Pro Tyr Tyr Phe Asp Glu Ile Gln Gly Met 
225                 230                 235                 240 


Thr Tyr Ala Glu Ser Glu Ser Ile Leu Tyr Ala Thr Phe Arg Thr Ser 
                245                 250                 255     


Gly Ser Ser Ile Phe Gly Ser Ala Val Cys Ala Tyr Asn Leu Ser Ser 
            260                 265                 270         


Ile Asn Ala Ala Phe Asp Gly Pro Phe Lys Gln Gln Glu His Ser Asp 
        275                 280                 285             


Ala Ala Trp Lys Thr Val Asn Thr Asn Gln Arg Ser Gln Phe Gln Cys 
    290                 295                 300                 


Gly Thr Ser Ser Ile Gly His Trp Leu Glu Ser Ser Arg Tyr Gln Leu 
305                 310                 315                 320 


Met Asp Glu Ala Val Gln Pro Ile Gly Ala Glu Pro Leu Tyr His Ser 
                325                 330                 335     


Lys Leu Glu Gln Phe Gly Arg Leu Ala Leu Asp Ile Ile Asn Thr Lys 
            340                 345                 350         


Thr Glu Gln Val His Val Leu Phe Val Ala Ser Ser Gly Asn His Ile 
        355                 360                 365             


Lys Lys Leu Ser Val Lys Tyr Asp Gly Asp Gly Val Gln Thr Cys Leu 
    370                 375                 380                 


Val Glu Leu Trp Gln Ala Asp Asp Thr Gly Thr Ser Ser Leu Leu Asn 
385                 390                 395                 400 


Met Ala Tyr Leu Lys Val Ser 
                405         


<210>  68
<211>  386
<212>  PRT
<213>  Mus musculus

<400>  68

Ile Gly Ala Ile Ala Ala Ser Arg Ala Asp Gly Val Phe Val Ala Ser 
1               5                   10                  15      


Gly Ser Cys Leu Asp Gln Leu Asp Tyr Ser Leu Lys Asn Arg Leu Ser 
            20                  25                  30          


Arg Leu Tyr Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu 
        35                  40                  45              


Ala Pro Pro Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu 
    50                  55                  60                  


Leu Pro Tyr Arg Glu Leu Glu Gly Leu Leu Leu Thr Gly Trp Thr Phe 
65                  70                  75                  80  


Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Asn Arg Ser 
                85                  90                  95      


Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly Ser 
            100                 105                 110         


Thr Ala Gly Val Val Tyr Arg Ala Ser Gly Thr Asp Leu Trp Tyr Leu 
        115                 120                 125             


Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Asn Arg 
    130                 135                 140                 


Cys Asn Pro Ala Ala Ser Asp Arg Asp Thr Ala Ile Ala Leu Lys Asn 
145                 150                 155                 160 


Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys Leu 
                165                 170                 175     


Arg Gly Ser Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp Asn 
            180                 185                 190         


Gly Ser Val Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly Ala 
        195                 200                 205             


Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu Val 
    210                 215                 220                 


Leu Phe Gln Gly Gln Ala Ala Leu Asp Cys Asp His Gly His Pro Glu 
225                 230                 235                 240 


Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Val Asp Ile 
                245                 250                 255     


Trp Ala Gly Val Phe Ser Ala Ala Thr Gly Glu Gly Gln Glu Arg Arg 
            260                 265                 270         


Ser Pro Ala Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile Gln 
        275                 280                 285             


Ala His Ala Arg Ser Cys Ser Trp Asp Phe Gln Ala Thr Glu His Asn 
    290                 295                 300                 


Cys Lys Glu Gly Asp Arg Pro Glu Arg Val Gln Pro Ile Ala Ser Ser 
305                 310                 315                 320 


Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val Met 
                325                 330                 335     


Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu Lys 
            340                 345                 350         


Val Val Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile Tyr 
        355                 360                 365             


Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro His Pro 
    370                 375                 380                 


Met Lys 
385     


<210>  69
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  69

Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys Leu Thr Ala Thr Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Cys His Ser Leu Gln Arg Cys Thr Phe Gln Gly 
            20                  25                  30          


Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp Leu Asp Ile Ser Ser 
        35                  40                  45              


Gly Ala Lys Lys Cys Pro 
    50                  


<210>  70
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  70

Arg Cys Asp Val Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Ser Gln Cys Ser Arg Tyr Phe Pro 
            20                  25                  30          


Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro 
        35                  40                  45              


Leu Thr Gln Cys Ser 
    50              


<210>  71
<211>  53
<212>  PRT
<213>  Drosophila melanogaster

<400>  71

Asp Cys Ser Asp Tyr Lys Thr Cys Gly Asp Cys Leu Gly Ala Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Gly Trp Cys Ser Leu Glu Asn Lys Cys Ser Pro Arg Ser 
            20                  25                  30          


Asn Cys Gln Asp Asp Ala Asn Asp Pro Phe Tyr Trp Val Ser Tyr Lys 
        35                  40                  45              


Thr Gly Lys Cys Thr 
    50              


<210>  72
<211>  53
<212>  PRT
<213>  Colius striatus

<400>  72

Arg Cys Arg Ile Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ser Cys Ser Arg Phe Tyr Pro 
            20                  25                  30          


Thr Gly Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
        35                  40                  45              


Leu Thr Gln Cys Arg 
    50              


<210>  73
<211>  52
<212>  PRT
<213>  Caenorhabditis elegans

<400>  73

Asn Cys Ala Gln Gln Thr Ser Cys Ser Lys Cys Val Gln Leu Gln Asp 
1               5                   10                  15      


Pro His Cys Ala Trp Asp Ser Ser Ile Ala Arg Cys Val His Gly Gly 
            20                  25                  30          


Ser Trp Thr Gly Asp Gln Phe Ile Gln Asn Met Val Phe Gly Gln Ser 
        35                  40                  45              


Glu Gln Cys Pro 
    50          


<210>  74
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser Arg Tyr Ala Pro 
            20                  25                  30          


Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys Tyr Gly Asp Pro 
        35                  40                  45              


Ile Thr Gln Cys Trp 
    50              


<210>  75
<211>  52
<212>  PRT
<213>  Mus musculus

<400>  75

Asn Cys Gly Arg Leu Gln Ser Cys Ser Glu Cys Ile Leu Ala Gln Asp 
1               5                   10                  15      


Pro Val Cys Ala Trp Ser Phe Arg Leu Asp Ala Cys Val Ala His Ala 
            20                  25                  30          


Gly Glu His Arg Gly Met Val Gln Asp Ile Glu Ser Ala Asp Val Ser 
        35                  40                  45              


Ser Leu Cys Pro 
    50          


<210>  76
<211>  53
<212>  PRT
<213>  Drosophila melanogaster

<400>  76

His Cys Ser Val Tyr Thr Asn Cys Ser Ala Cys Leu Glu Ser Arg Asp 
1               5                   10                  15      


Pro Phe Cys Gly Trp Cys Ser Leu Glu Lys Arg Cys Thr Val Arg Ser 
            20                  25                  30          


Thr Cys Gln Arg Asp Thr Ser Ala Ser Arg Trp Leu Ser Leu Gly Ser 
        35                  40                  45              


Gly Gln Gln Cys Ile 
    50              


<210>  77
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  77

Ser Cys Glu Gln Tyr Thr Thr Cys Gly Glu Cys Leu Ser Ser Gly Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Cys Ala Leu His Asn Met Cys Ser Arg Arg Asp 
            20                  25                  30          


Lys Cys Gln Gln Ala Trp Glu Pro Asn Arg Phe Ala Ala Ser Ile Ser 
        35                  40                  45              


Gln Cys Val 
    50      


<210>  78
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  78

Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys Val Leu Ala Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr Cys Val Ala Leu His 
            20                  25                  30          


Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln Glu Met Ser Gly Asp 
        35                  40                  45              


Ala Ser Val Cys Pro 
    50              


<210>  79
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  79

Arg Cys Thr Ala Leu Gly Arg Ala Cys Ala Glu Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Thr Arg Phe Gln Pro 
            20                  25                  30          


Thr Ala Lys Arg Arg Phe Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro 
        35                  40                  45              


Ser Thr Leu Cys Ser 
    50              


<210>  80
<211>  53
<212>  PRT
<213>  Danio rerio

<400>  80

Arg Cys Gln Ile Tyr Gly Gln Gly Cys Ala Glu Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Thr Gln Cys Ser Arg Tyr Ile Pro 
            20                  25                  30          


Ala Ser Lys Arg Arg Ala Arg Arg Gln Asp Ile Lys His Gly Asp Pro 
        35                  40                  45              


Ser Ser His Cys Trp 
    50              


<210>  81
<211>  52
<212>  PRT
<213>  Mus musculus

<400>  81

Asn Cys Ser Val Tyr Glu Ser Cys Val Asp Cys Val Leu Ala Arg Asp 
1               5                   10                  15      


Pro His Cys Ala Trp Asp Pro Glu Ser Arg Leu Cys Ser Leu Leu Ser 
            20                  25                  30          


Gly Ser Thr Lys Pro Trp Lys Gln Asp Met Glu Arg Gly Asn Pro Glu 
        35                  40                  45              


Trp Val Cys Thr 
    50          


<210>  82
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Cys Glu Val Tyr Gly Gly Gly Cys His Gly Cys Leu Met Ser Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Gly Trp Asp Gln Gly Arg Cys Ile Ser Ile Tyr Ser 
            20                  25                  30          


Ser Glu Arg Ser Val Leu Gln Ser Ile Asn Pro Ala Glu Pro His Lys 
        35                  40                  45              


Glu Cys Pro 
    50      


<210>  83
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            20                  25                  30          


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        35                  40                  45              


Pro Glu Leu Gly Cys Leu 
    50                  


<210>  84
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  84

Phe Cys Glu Lys His Gly Ser Cys Glu Asp Cys Val Leu Ala Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Ala Trp Ser Pro Ala Ile Lys Ala Cys Val Thr Leu His 
            20                  25                  30          


Gln Glu Glu Ala Ser Ser Arg Gly Trp Ile Gln Asp Met Ser Gly Asp 
        35                  40                  45              


Thr Ser Ser Cys Leu 
    50              


<210>  85
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Cys Gln Ala Tyr Gly Ala Ala Cys Ala Asp Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Gln Ala Cys Ser Arg Tyr Thr Ala 
            20                  25                  30          


Ser Ser Lys Arg Arg Ser Arg Arg Gln Asp Val Arg His Gly Asn Pro 
        35                  40                  45              


Ile Arg Gln Cys Arg 
    50              


<210>  86
<211>  53
<212>  PRT
<213>  Tribolium confusum

<400>  86

His Cys Ala Ser Lys Thr Arg Cys Lys Asp Cys Val Glu Leu Gln Asp 
1               5                   10                  15      


Pro His Cys Ala Trp Asp Ala Lys Gln Asn Leu Cys Val Ser Ile Asp 
            20                  25                  30          


Thr Val Thr Ser Tyr Arg Phe Leu Ile Gln Asp Val Val Arg Gly Asp 
        35                  40                  45              


Asp Asn Lys Cys Trp 
    50              


<210>  87
<211>  55
<212>  PRT
<213>  Danio rerio

<400>  87

Glu Cys Gly Arg Tyr Gln Thr Cys Leu Asp Cys Val Leu Ala Arg Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Asp Leu Asp Thr Glu His Cys Ala Thr Ile Asn 
            20                  25                  30          


Ser Ile His Arg Thr Arg Ser Ser Thr Val Ile Gln Ser Leu Asn Asp 
        35                  40                  45              


Gly Asp Ala Ser Gln Cys Pro 
    50                  55  


<210>  88
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  88

Thr Cys Glu Gln Tyr Gln Ser Cys Ala Ala Cys Leu Gly Ser Gly Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Cys Val Leu Arg His Arg Cys Cys Arg Glu Gly 
            20                  25                  30          


Ala Cys Leu Gly Ala Ser Ala Pro His Gly Phe Ala Glu Glu Leu Ser 
        35                  40                  45              


Lys Cys Val 
    50      


<210>  89
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  89

Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln Cys Arg Asp Ser Gln Asp 
1               5                   10                  15      


Pro Tyr Cys Gly Trp Cys Val Val Glu Gly Arg Cys Thr Arg Lys Ala 
            20                  25                  30          


Glu Cys Pro Arg Ala Glu Glu Ala Ser His Trp Leu Trp Ser Arg Ser 
        35                  40                  45              


Lys Ser Cys Val 
    50          


<210>  90
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  90

Arg Cys Gln Phe Tyr Arg Thr Arg Ser Thr Cys Ile Gly Ala Gln Asp 
1               5                   10                  15      


Pro Tyr Cys Gly Trp Asp Val Val Met Lys Lys Cys Thr Ser Leu Glu 
            20                  25                  30          


Glu Ser Leu Ser Met Thr Gln Trp Glu Gln Ser Ile Ser Ala Cys Pro 
        35                  40                  45              


<210>  91
<211>  51
<212>  PRT
<213>  Xenopus laevis

<400>  91

Ser Cys Glu Gln Tyr Glu Ser Cys Asp Thr Cys Leu Gly Ser Arg Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Cys Val Leu His Asn Met Cys Ser Arg Lys Asp 
            20                  25                  30          


Lys Cys Glu Arg Ala Asp Glu Leu His Arg Phe Thr Ser Asp Gln Arg 
        35                  40                  45              


Gln Cys Val 
    50      


<210>  92
<211>  53
<212>  PRT
<213>  Danio rerio

<400>  92

Gln Cys Asp Leu Tyr Gly Gln Ala Cys Ala Glu Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Thr Trp Asp Gly His Ser Cys Ser Gln Phe Met Pro 
            20                  25                  30          


Thr Gly Arg Arg Arg Asn Ile Arg Gln Val Asn Asp Asp Gly Asn Pro 
        35                  40                  45              


Leu Asn Gln Cys Val 
    50              


<210>  93
<211>  56
<212>  PRT
<213>  Gallus gallus

<400>  93

Gln Cys Asp Met Tyr Gly Thr Ala Cys Ala Asp Cys Cys Leu Ala Arg 
1               5                   10                  15      


Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys Ser Arg Tyr Tyr Pro 
            20                  25                  30          


Thr Gly Met Gln Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg His 
        35                  40                  45              


Gly Asn Ala Ala Gln Gln Cys Phe 
    50                  55      


<210>  94
<211>  51
<212>  PRT
<213>  Mus musculus

<400>  94

Ser Cys Val Gln Tyr Thr Ser Cys Glu Leu Cys Leu Gly Ser Arg Asp 
1               5                   10                  15      


Pro His Cys Gly Trp Cys Val Leu His Ser Ile Cys Ser Arg Gln Asp 
            20                  25                  30          


Ala Cys Glu Arg Ala Glu Glu Pro Gln Arg Phe Ala Ser Asp Leu Leu 
        35                  40                  45              


Gln Cys Val 
    50      


<210>  95
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  95

Asn Cys Ser Val Leu Gln Ser Cys Met Ser Cys Val Gly Ser Pro Tyr 
1               5                   10                  15      


Pro Cys His Trp Cys Lys Tyr Arg His Thr Cys Thr Ser Arg Pro His 
            20                  25                  30          


Glu Cys Ser Phe Gln Glu Gly Arg Val His Ser Pro Glu Gly Cys Pro 
        35                  40                  45              


<210>  96
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp 
1               5                   10                  15      


Ala Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln 
            20                  25                  30          


Asp Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu 
        35                  40                  45              


Gly Pro Ser Arg Cys Pro 
    50                  


<210>  97
<211>  57
<212>  PRT
<213>  Drosophila melanogaster

<400>  97

Arg Cys His Asn Asp Lys Ile Thr Ser Cys Ser Glu Cys Val Ala Leu 
1               5                   10                  15      


Gln Asp Pro Tyr Cys Ala Trp Asp Lys Ile Ala Gly Lys Cys Arg Ser 
            20                  25                  30          


His Gly Ala Pro Arg Trp Leu Glu Glu Asn Tyr Phe Tyr Gln Asn Val 
        35                  40                  45              


Ala Thr Gly Gln His Ala Ala Cys Pro 
    50                  55          


<210>  98
<211>  44
<212>  PRT
<213>  Rattus norvegicus

<400>  98

Gly Cys Gly His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Tyr 
1               5                   10                  15      


Phe Ile Gln Cys Gly Trp Cys His Asn Arg Cys Val His Ser Asn Glu 
            20                  25                  30          


Cys Pro Ser Gly Thr Trp Thr Gln Glu Ile Cys Leu 
        35                  40                  


<210>  99
<211>  54
<212>  PRT
<213>  Xenopus laevis

<400>  99

Lys Cys Ser Ala Leu Arg Glu Ser Cys Gly Leu Cys Leu Lys Ser Asp 
1               5                   10                  15      


Arg Arg Phe Glu Cys Gly Trp Cys Val Ser Glu Lys Lys Cys Thr Leu 
            20                  25                  30          


Arg Gln Asn Cys Pro Thr Leu Glu Asn Pro Trp Met His Ala Ser Thr 
        35                  40                  45              


Ala Asn Ser Arg Cys Thr 
    50                  


<210>  100
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  100

Lys Cys Trp Ala Gln Arg Pro Ser Cys Gly Leu Cys Leu Lys Ala Asp 
1               5                   10                  15      


Pro Arg Phe Asn Cys Gly Trp Cys Ile Ser Glu His Arg Cys Gln Leu 
            20                  25                  30          


Arg Thr His Cys Pro Ala Pro Lys Thr Asn Trp Met His Leu Ser Gln 
        35                  40                  45              


Lys Gly Thr Arg Cys Ser 
    50                  


<210>  101
<211>  55
<212>  PRT
<213>  Mus musculus

<400>  101

Lys Cys Pro Ala Leu Arg Gln Ser Cys Gly Leu Cys Leu Lys Ala Asp 
1               5                   10                  15      


Pro Arg Phe Glu Cys Gly Trp Cys Val Ala Glu Arg Arg Cys Ser Leu 
            20                  25                  30          


Arg His His Cys Pro Ala Asp Ser Pro Ala Ser Trp Met His Ala His 
        35                  40                  45              


His Gly Ser Ser Arg Cys Thr 
    50                  55  


<210>  102
<211>  51
<212>  PRT
<213>  Bos taurus

<400>  102

Glu Cys Thr Asn Tyr Lys Val Ser Thr Cys Arg Asp Cys Ile Glu Ser 
1               5                   10                  15      


Gly Pro Gly Cys Ala Trp Cys Gln Lys Leu Asn Phe Thr Gly Gln Gly 
            20                  25                  30          


Glu Pro Asp Ser Ile Arg Cys Asp Thr Arg Ala Glu Leu Leu Ser Lys 
        35                  40                  45              


Gly Cys Pro 
    50      


<210>  103
<211>  50
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  103

Arg Cys Ala Ser Ser His Ala Val Ser Cys Ser Glu Cys Leu Ala Leu 
1               5                   10                  15      


Gly Pro Asp Cys Gly Trp Cys Val His Glu Asp Phe Ile Ser Gly Gly 
            20                  25                  30          


Pro Arg Ser Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly 
        35                  40                  45              


Cys Pro 
    50  


<210>  104
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Cys Arg His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro 
1               5                   10                  15      


Phe Val Gln Cys Gly Trp Cys His Asp Lys Cys Val Arg Ser Glu Glu 
            20                  25                  30          


Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile Cys Leu 
        35                  40                  


<210>  105
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  105

Asn Cys Ser Leu Tyr Pro Thr Cys Gly Asp Cys Leu Leu Ala Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Ala Trp Thr Gly Ser Ala Cys Arg Leu Ala Ser Leu Val 
            20                  25                  30          


Lys Glu Leu Cys Lys Asn Ser Ser Tyr Lys Ala Arg Phe Leu Val Pro 
        35                  40                  45              


Gly Lys Pro Cys Lys 
    50              


<210>  106
<211>  48
<212>  PRT
<213>  Xenopus laevis

<400>  106

Asn Cys Ser Val His Gln Ser Cys Leu Ser Cys Val Asn Gly Ser Phe 
1               5                   10                  15      


Pro Cys His Trp Cys Lys Tyr Arg His Val Cys Thr His Asn Ala Ala 
            20                  25                  30          


Asp Cys Ser Phe Gln Glu Gly Arg Val Asn Met Ser Glu Asp Cys Pro 
        35                  40                  45              


<210>  107
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  107

Asn Cys Ser Gly Leu Arg Thr Cys Gly Gln Cys Leu Glu Gln Pro Gly 
1               5                   10                  15      


Cys Gly Trp Cys Asn Asp Arg Gly His Cys Ile Glu Gly Ser Ser Asp 
            20                  25                  30          


Thr Asn Leu Cys Pro Lys Glu Lys Asn Tyr Glu Trp Ser Phe Ile Gln 
        35                  40                  45              


Cys Pro 
    50  


<210>  108
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Cys Leu Lys Ala Asn Ala Lys Ser Cys Gly Glu Cys Ile Gln Ala 
1               5                   10                  15      


Gly Pro Asn Cys Gly Trp Cys Thr Asn Ser Thr Phe Leu Gln Glu Gly 
            20                  25                  30          


Met Pro Thr Ser Ala Arg Cys Asp Asp Leu Glu Ala Leu Lys Lys Lys 
        35                  40                  45              


Gly Cys Pro 
    50      


<210>  109
<211>  44
<212>  PRT
<213>  Gallus gallus

<400>  109

Gly Cys His His Phe Gln Ser Cys Ser Gln Cys Leu Leu Ala Pro Ala 
1               5                   10                  15      


Phe Met Arg Cys Gly Trp Cys Gly Gln Gln Cys Leu Arg Ala Pro Glu 
            20                  25                  30          


Cys Asn Gly Gly Thr Trp Thr Gln Glu Thr Cys Leu 
        35                  40                  


<210>  110
<211>  54
<212>  PRT
<213>  Drosophila melanogaster

<400>  110

Arg Cys Arg Glu Met Ala Asp Ser Cys Gly Ile Cys Leu Ala Leu Ser 
1               5                   10                  15      


Glu Lys Tyr Asn Cys Gly Trp Cys Ser Ser Thr Asn Thr Cys Glu Val 
            20                  25                  30          


Glu Glu Gln Cys Asn Lys Asn Lys Glu Gly Lys Thr Asp Trp Leu Asn 
        35                  40                  45              


Arg Ser Glu Ile Cys Pro 
    50                  


<210>  111
<211>  44
<212>  PRT
<213>  Takifugu rubripes

<400>  111

Gly Cys Asp His Leu Thr Thr Cys Thr Ser Cys Leu Val Ser Ser Arg 
1               5                   10                  15      


Val Thr Glu Cys Gly Trp Cys Glu Gly Arg Cys Thr Arg Ala Asn Gln 
            20                  25                  30          


Cys Pro Pro Ser Val Trp Thr Gln Glu Tyr Cys Thr 
        35                  40                  


<210>  112
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  112

Lys Cys Ala Ala Gln Arg Glu Ser Cys Gly Leu Cys Leu Lys Ala Asp 
1               5                   10                  15      


His Lys Phe Glu Cys Gly Trp Cys Ser Gly Glu Arg Arg Cys Thr Leu 
            20                  25                  30          


His Gln His Cys Pro Ser Thr Ser Ser Pro Trp Leu Asp Trp Ser Ser 
        35                  40                  45              


His Asn Val Lys Cys Ser 
    50                  


<210>  113
<211>  43
<212>  PRT
<213>  Caenorhabditis elegans

<400>  113

Thr Cys Ser His His Ser Ser Cys Thr Glu Cys Leu Val Ser Val Asp 
1               5                   10                  15      


Pro Leu Cys Gln Trp Cys His Pro Thr Gln Ser Cys Thr Thr Ser Ala 
            20                  25                  30          


Arg Cys Thr Ser Pro Val Thr Ser Gln Cys Pro 
        35                  40              


<210>  114
<211>  43
<212>  PRT
<213>  Gallus gallus

<400>  114

Gly Cys Arg His Phe Ser Thr Cys Asp Arg Cys Leu Arg Ala Glu Arg 
1               5                   10                  15      


Phe Met Gly Cys Gly Trp Cys Gly Asn Gly Cys Thr Arg His His Glu 
            20                  25                  30          


Cys Ala Gly Pro Trp Val Gln Asp Ser Cys Pro 
        35                  40              


<210>  115
<211>  43
<212>  PRT
<213>  Takifugu rubripes

<400>  115

Gly Cys Ala His Phe Arg Thr Cys Ser Met Cys Leu Met Ala Pro Arg 
1               5                   10                  15      


Phe Met Asn Cys Gly Trp Cys Ser Gly Val Cys Ser Arg Gln His Gln 
            20                  25                  30          


Cys Asp Met Gln Trp Glu Lys Asp Ser Cys Ala 
        35                  40              


<210>  116
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  116

Arg Cys Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn 
1               5                   10                  15      


Asp Cys His Trp Cys Asn Asp His Cys Val Pro Val Asn His Ser Cys 
            20                  25                  30          


Thr Glu Gly Gln Ile Ser Ile Ala Lys Tyr Glu Ser Cys Pro 
        35                  40                  45      


<210>  117
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  117

Asn Cys Ser Ala His Gln Leu Cys Leu Ser Cys Val Asn Ser Ala Phe 
1               5                   10                  15      


Arg Cys His Trp Cys Lys Tyr Arg Asn Leu Cys Thr His Asp Pro Thr 
            20                  25                  30          


Thr Cys Ser Phe Gln Glu Gly Arg Ile Asn Ile Ser Glu Asp Cys Pro 
        35                  40                  45              


<210>  118
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  118

Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His 
1               5                   10                  15      


Phe Met Gly Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu 
            20                  25                  30          


Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro 
        35                  40              


<210>  119
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  119

Asn Cys Ser Gly Tyr Cys Thr Cys Ser His Cys Leu Glu Gln Pro Gly 
1               5                   10                  15      


Cys Gly Trp Cys Thr Asp Lys Gly Lys Cys Ile Glu Gly Ser Tyr Asn 
            20                  25                  30          


Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser Phe Ile His 
        35                  40                  45              


Cys Pro 
    50  


<210>  120
<211>  48
<212>  PRT
<213>  Drosophila melanogaster

<400>  120

Asp Cys Ser His His Gly Asn Cys Gln Glu Cys Leu Gln Ser Ser Trp 
1               5                   10                  15      


Gly Cys Asn Trp Cys Ile Phe Asp Asn Lys Cys Val His Lys Ser Leu 
            20                  25                  30          


Gln Cys Arg Asn Ile Glu Asn Ala Val Ser Thr Val Gly His Cys Pro 
        35                  40                  45              


<210>  121
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  121

Asn Cys Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys 
1               5                   10                  15      


Ala Trp Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys 
            20                  25                  30          


Asp Pro Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro 
        35                  40                  45  


<210>  122
<211>  41
<212>  PRT
<213>  Caenorhabditis elegans

<400>  122

Asp Cys Ser Gly Tyr Gly Thr Cys Ser Ser Cys Met Ser Ser Glu Tyr 
1               5                   10                  15      


Asn Cys Ala Trp Cys Ser Gly Leu His Lys Cys Ser Asn Ser Cys Gly 
            20                  25                  30          


Ala Leu Glu Lys Ser Lys Ala Cys Val 
        35                  40      


<210>  123
<211>  58
<212>  PRT
<213>  Schistocerca americana

<400>  123

Arg Cys Gly Ser Asp Lys Ile Thr Asn Cys Arg Glu Cys Val Ser Leu 
1               5                   10                  15      


Gln Asp Pro Tyr Cys Ala Trp Asp Asn Val Glu Leu Lys Cys Thr Ala 
            20                  25                  30          


Val Gly Ser Pro Asp Trp Ser Ala Gly Lys Arg Arg Phe Ile Gln Asn 
        35                  40                  45              


Ile Ser Leu Gly Glu His Lys Ala Cys Gly 
    50                  55              


<210>  124
<211>  47
<212>  PRT
<213>  Mus musculus

<400>  124

Arg Cys Ser Ala Tyr Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pro 
1               5                   10                  15      


Tyr Cys Gly Trp Asp Gly Lys Arg Gln Leu Cys Ser Thr Leu Glu Asp 
            20                  25                  30          


Ser Ser Asn Met Ser Leu Trp Ile Gln Asn Ile Thr Thr Cys Pro 
        35                  40                  45          


<210>  125
<211>  51
<212>  PRT
<213>  Gallus gallus

<400>  125

Glu Cys Pro Lys Ile Lys Val Gly Thr Cys Lys Asn Cys Ile Gln Ser 
1               5                   10                  15      


Gly Pro Gly Cys Ala Trp Cys Lys Lys Leu Ser Phe Thr Lys Ala Gly 
            20                  25                  30          


Glu Pro Asp Ser Asn Arg Cys Asp Thr Ile Glu Gln Leu Gln Gln Arg 
        35                  40                  45              


Gly Cys Pro 
    50      


<210>  126
<211>  43
<212>  PRT
<213>  Xenopus laevis

<400>  126

Thr Cys Gly His Leu Lys Ser Cys Ser His Cys Leu Ser Ser Pro Ser 
1               5                   10                  15      


Val Asn Cys Gly Trp Ser Lys Asn His Cys Ser Thr Lys Gln Glu Cys 
            20                  25                  30          


Leu Asn Glu Glu Trp Ile Gln Glu Thr Cys Pro 
        35                  40              


<210>  127
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  127

Ser Cys Gln Pro Ala Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro 
1               5                   10                  15      


Ser Cys Ala Trp Cys Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala 
            20                  25                  30          


Glu Ala Arg Arg Cys Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys 
        35                  40                  45              


Pro 
    


<210>  128
<211>  48
<212>  PRT
<213>  Mus musculus

<400>  128

Pro Cys Ala Leu Arg Thr Ala Cys Gly Glu Cys Thr Ser Ser Ser Ser 
1               5                   10                  15      


Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp Ser Asn Ala 
            20                  25                  30          


Phe Pro Phe Gly Gln Cys Met Glu Trp Tyr Thr Met Ser Ser Cys Pro 
        35                  40                  45              


<210>  129
<211>  50
<212>  PRT
<213>  Mus musculus

<400>  129

Ile Cys Thr Ser Gly Ser Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile 
1               5                   10                  15      


His Pro Lys Cys Ala Trp Cys Ser Lys Glu Tyr Phe Gly Asn Pro Arg 
            20                  25                  30          


Ser Ile Thr Ser Arg Cys Asp Leu Lys Ala Asn Leu Ile Arg Asn Gly 
        35                  40                  45              


Cys Glu 
    50  


<210>  130
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  130

Asp Cys Thr Lys Tyr Arg Phe Cys Val Asp Cys Val Leu Ala Arg Asp 
1               5                   10                  15      


Pro Tyr Cys Ala Trp Asn Val Asn Thr Ser Arg Cys Val Ala Thr Thr 
            20                  25                  30          


Ser Gly Arg Ser Gly Ser Phe Leu Val Gln His Val Ala Asn Leu Asp 
        35                  40                  45              


Thr Ser Lys Met Cys Asn 
    50                  


<210>  131
<211>  51
<212>  PRT
<213>  Pan troglodytes

<400>  131

Glu Cys Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu Ser 
1               5                   10                  15      


Gly Pro Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro Gly 
            20                  25                  30          


Asp Pro Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met Arg 
        35                  40                  45              


Gly Cys Ala 
    50      


<210>  132
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  132

Gln Cys Asp Ala His Arg Ser Glu Ala Ala Cys Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Ile Arg Cys Val Trp Asn Thr Gly Ser Ser Gln Cys Ile Ser Trp 
            20                  25                  30          


Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys Leu Lys Ser Glu Cys Phe 
        35                  40                  45              


<210>  133
<211>  48
<212>  PRT
<213>  Mus musculus

<400>  133

Gln Cys Asp Ala His Arg Ser Glu Ala Ala Cys Val Ala Ala Gly Pro 
1               5                   10                  15      


Gly Ile Arg Cys Leu Trp Asp Thr Gln Ser Ser Arg Cys Thr Ser Trp 
            20                  25                  30          


Glu Leu Ala Thr Glu Glu Gln Ala Glu Lys Leu Lys Ser Glu Cys Phe 
        35                  40                  45              


<210>  134
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  134

Asn Cys Ser Phe Gly Arg Ser Asp Cys Ser Leu Cys Arg Ala Ala Asn 
1               5                   10                  15      


Pro Asp Tyr Arg Cys Ala Trp Cys Gly Gly Gln Ser Arg Cys Val Tyr 
            20                  25                  30          


Glu Ala Leu Cys Asn Thr Thr Ser Glu Cys Pro 
        35                  40              


<210>  135
<211>  50
<212>  PRT
<213>  Paramecium tetraurelia

<400>  135

Ile Cys Gln Gln Leu Arg Glu Cys Asp Ser Cys Leu Ser Arg Glu Gly 
1               5                   10                  15      


Cys Ile Trp Cys Thr Glu Glu Gln Thr Cys Gln Glu Gly Asn Ala Arg 
            20                  25                  30          


Asp Gly Ala Phe Phe Asn Ser Cys Asp Ile Trp Val Ser Gly Ser Glu 
        35                  40                  45              


Cys Pro 
    50  


<210>  136
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  136

Asp Cys Ser Val Gly His Gly Asp Cys Ser Arg Cys Gln Thr Ala Met 
1               5                   10                  15      


Pro Gln Tyr Gly Cys Val Trp Cys Glu Gly Glu Arg Pro Arg Cys Val 
            20                  25                  30          


Thr Arg Glu Ala Cys Gly Glu Ala Glu Ala Val Ala Thr Gln Cys Pro 
        35                  40                  45              


<210>  137
<211>  47
<212>  PRT
<213>  Caenorhabditis elegans

<400>  137

Thr Cys Glu Glu Gln Thr Asp Cys Val Ser Cys Ala Ser Lys Ser Gly 
1               5                   10                  15      


Cys Gly Trp Cys Ser Ser Gly Glu Gln Cys Leu Pro Asn Glu Gln Glu 
            20                  25                  30          


Cys Val Asp Gly Pro Gly Met Leu Thr Ser Trp Glu Lys Cys Pro 
        35                  40                  45          


<210>  138
<211>  47
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  138

Ala Cys Ser Asp Ala Lys Thr Cys Gly Glu Cys Ile Ser Leu Asp Ser 
1               5                   10                  15      


Ser Cys Gly Trp Cys Thr Leu Leu Asn Tyr Thr Asp Asp Thr Gly Asn 
            20                  25                  30          


Pro Gln Cys Asp Leu Ala Ser Ser Leu Ser Gln Arg Gly Cys Ser 
        35                  40                  45          


<210>  139
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  139

Gly Cys Ala Gln Ala Thr Gln Cys Ala Leu Cys Leu Arg Arg Pro His 
1               5                   10                  15      


Cys Gly Trp Cys Ala Trp Gly Gly Arg Cys Met Glu Gly Gly Leu Ser 
            20                  25                  30          


Gly Pro Arg Asp Gly Leu Thr Cys Gly Arg Pro Gly Ala Ser Trp Ala 
        35                  40                  45              


Phe Leu Ser Cys Pro 
    50              


<210>  140
<211>  50
<212>  PRT
<213>  Drosophila melanogaster

<400>  140

Lys Cys Asp Val Leu Gly Pro Asp Cys Ser Leu Cys Val Thr Arg Asp 
1               5                   10                  15      


Pro Lys Tyr Lys Cys Ala Trp Cys Ser Asn Asn Glu Thr Cys Ile Ala 
            20                  25                  30          


Asp Lys Asn Ser Ile Ser Ser Gly Ser Lys Ser Ala Ile Glu Asn Glu 
        35                  40                  45              


Cys Pro 
    50  


<210>  141
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  141

Pro Cys Ser Leu Arg Thr Ser Cys Ser Asn Cys Thr Ser Asn Gly Met 
1               5                   10                  15      


Glu Cys Met Trp Cys Ser Ser Thr Lys Arg Cys Val Asp Ser Asn Ala 
            20                  25                  30          


Phe Pro Tyr Gly Gln Cys Leu Glu Trp Gln Thr Ala Thr Cys Ser 
        35                  40                  45          


<210>  142
<211>  47
<212>  PRT
<213>  Lytechinus variegatus

<400>  142

Ser Cys Leu Gln Ala Arg Thr Cys Gly Asp Cys Ile Ile Thr Asp Pro 
1               5                   10                  15      


Ser Cys Ala Trp Cys Ala Gln Pro Asp Phe Gln Asp Ala Glu Asn Tyr 
            20                  25                  30          


Pro Arg Cys Asp Ser Pro Asp Thr Leu Arg Glu Arg Gly Cys Met 
        35                  40                  45          


<210>  143
<211>  50
<212>  PRT
<213>  Caenorhabditis elegans

<400>  143

Val Cys Glu Glu His Lys Thr Cys Gly Glu Cys Gln Arg Asp Pro Gly 
1               5                   10                  15      


Cys Gly Trp Leu Ala Asp Leu Gly Leu Cys Ile Arg Gly Thr Ser Thr 
            20                  25                  30          


Gly Pro Leu Glu Pro Lys Pro Glu Asn Ser Thr Trp Tyr Phe Ile Asp 
        35                  40                  45              


Cys Pro 
    50  


<210>  144
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  144

Asp Cys Ser Arg Thr Ala Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln 
1               5                   10                  15      


Trp Pro Cys Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn Gln 
            20                  25                  30          


Ser Arg Cys Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro 
        35                  40                  45              


<210>  145
<211>  47
<212>  PRT
<213>  Mus musculus

<400>  145

Ile Cys Thr Ala Arg Gly Val Asn Ser Cys Gln Gln Cys Leu Ala Val 
1               5                   10                  15      


Ser Pro Val Cys Ala Trp Cys Ser Asp Glu Thr Leu Ser Gln Gly Ser 
            20                  25                  30          


Pro Arg Cys Asn Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala 
        35                  40                  45          


<210>  146
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  146

Leu Cys Leu Gly Gly Ala Glu Thr Cys Glu Asp Cys Leu Leu Ile Gly 
1               5                   10                  15      


Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn Phe Thr His Pro Ser Gly 
            20                  25                  30          


Val Gly Glu Arg Cys Asp Thr Pro Ala Asn Leu Leu Ala Lys Gly Cys 
        35                  40                  45              


Gln 
    


<210>  147
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  147

Arg Cys Tyr Arg Tyr Ala Asp Cys Ala Ser Cys Thr Ala Asn Thr Asn 
1               5                   10                  15      


Gly Cys Gln Trp Cys Asp Asp Lys Lys Cys Ile Ser Ala Asn Ser Asn 
            20                  25                  30          


Cys Ser Met Ser Val Lys Asn Tyr Thr Lys Cys His 
        35                  40                  


<210>  148
<211>  42
<212>  PRT
<213>  Caenorhabditis elegans

<400>  148

Pro Cys Ala Gln Arg Asn Asn Cys Ser Asp Cys Thr Asp Leu Glu Gln 
1               5                   10                  15      


Cys Met Trp Cys Pro Ser Thr Asn Arg Cys Ile Asn Leu Glu Ala Tyr 
            20                  25                  30          


Thr Leu Ser Phe Ala Tyr Gly Gln Cys His 
        35                  40          


<210>  149
<211>  50
<212>  PRT
<213>  Mus musculus

<400>  149

Gly Cys Ala Trp Gly Gly Ala Glu Ser Cys Ser Asp Cys Leu Leu Thr 
1               5                   10                  15      


Gly Pro His Cys Ala Trp Cys Ser Gln Glu Asn Phe Thr His Leu Ser 
            20                  25                  30          


Gly Ala Gly Glu Arg Cys Asp Thr Pro Ala Asn Leu Leu Ala Lys Gly 
        35                  40                  45              


Cys Gln 
    50  


<210>  150
<211>  42
<212>  PRT
<213>  Caenorhabditis elegans

<400>  150

Ser Cys Thr Asn Leu Ala Ser Asp Cys Ser Ser Cys Leu Ala Leu Ser 
1               5                   10                  15      


Pro Ser Leu Ser Cys Gly Trp Cys Asn Arg Gln Cys Ser His Glu Cys 
            20                  25                  30          


His Glu Ser Lys Ala Thr Ala Val Cys Asp 
        35                  40          


<210>  151
<211>  47
<212>  PRT
<213>  Xenopus laevis

<400>  151

Ile Cys Ala Thr Arg Gly Val Ser Ser Cys Gln Lys Cys Leu Ser Val 
1               5                   10                  15      


Ser Pro Gln Cys Ala Trp Cys Ser Gln Glu Val Phe Gly Lys Gly Ala 
            20                  25                  30          


Pro Arg Cys Asp Leu Lys Ser Glu Leu Leu Ser Asn Gly Cys Glu 
        35                  40                  45          


<210>  152
<211>  42
<212>  PRT
<213>  Acropora millepora

<400>  152

Ala Cys Thr Arg Leu Thr Lys Cys Asn Gln Cys Ile Gly Glu Ala Asn 
1               5                   10                  15      


Cys Ala Trp Cys Ser Asp Lys Asp Phe Gly Ser Ser Arg Cys Asp Ser 
            20                  25                  30          


Gln Lys Ile Leu Glu Leu Asn Gly Cys Ser 
        35                  40          


<210>  153
<211>  36
<212>  PRT
<213>  Drosophila melanogaster

<400>  153

Asp Cys Ser Thr His Ser Ser Cys Thr Arg Cys Val Ser Ser Glu Phe 
1               5                   10                  15      


Pro Cys Asp Trp Cys Val Glu Ala His Arg Cys Thr His Asp Thr Ala 
            20                  25                  30          


Glu Asn Cys Arg 
        35      


<210>  154
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  154

Ala Cys Ser Gln Asn Thr Asn Lys Thr Cys Glu Glu Cys Leu Lys Asn 
1               5                   10                  15      


Val Ser Cys Leu Trp Cys Asn Thr Asn Lys Ala Cys Leu Asp Tyr Pro 
            20                  25                  30          


Val Pro Pro Ala Ser Leu Cys Lys Leu Ser Ser Ala Arg Trp Gly Val 
        35                  40                  45              


Cys Trp 
    50  


<210>  155
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  155

Ile Cys Asn Lys Leu Thr Ser Cys Lys Ser Cys Ser Leu Asn Leu Asn 
1               5                   10                  15      


Cys Gln Trp Asp Gln Arg Gln Gln Glu Cys Gln Ala Leu Pro Ala His 
            20                  25                  30          


Leu Cys Gly Glu Gly Trp Ser His Ile Gly Asp Ala Cys Leu 
        35                  40                  45      


<210>  156
<211>  46
<212>  PRT
<213>  Caenorhabditis elegans

<400>  156

Thr Cys His Leu Ala Ser Asn Cys Ala Glu Cys Leu Ala His Gly Asp 
1               5                   10                  15      


Pro His Cys Ala Trp Ala Asp Gly Val Asp Cys Ile Asp Ile Arg Thr 
            20                  25                  30          


Asp Gln Arg Lys Ser Ala Ser Gln Asp Ser Gly Thr Cys Asp 
        35                  40                  45      


<210>  157
<211>  43
<212>  PRT
<213>  Danio rerio

<400>  157

Gly Cys Gln His Phe Leu Thr Cys Ala Val Cys Leu Thr Ala Pro Lys 
1               5                   10                  15      


Phe Val Gly Cys Gly Trp Cys Ser Gly Val Cys Ser Trp Glu Ser Asp 
            20                  25                  30          


Cys Asp His His Trp Arg Asn Asp Ser Cys Pro 
        35                  40              


<210>  158
<211>  53
<212>  PRT
<213>  Caenorhabditis elegans

<400>  158

Tyr Cys Arg Ile Gly Ser Asn Asp Leu Asn Thr Cys Glu Thr Cys Val 
1               5                   10                  15      


Gly Lys Gly Ser Asn Cys Phe Trp Cys Gly Gly Lys Thr Lys Arg Cys 
            20                  25                  30          


Met Pro Phe Asp Trp Tyr Tyr Pro Asp Cys Asn Ile Lys His Val Lys 
        35                  40                  45              


Tyr Asn Val Cys Trp 
    50              


<210>  159
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  159

Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp Gln Asn 
1               5                   10                  15      


Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro Glu Asn 
            20                  25                  30          


Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
        35                  40                  45      


<210>  160
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  160

Glu Cys Arg Arg Leu Arg Thr Cys Ser Glu Cys Leu Ala Arg His Pro 
1               5                   10                  15      


Arg Thr Leu Cys Lys Trp Cys Thr Asn Cys Pro Glu Gly Ala Cys Ile 
            20                  25                  30          


Gly Arg Asn Gly Ser Cys Thr Ser Glu Asn Asp Cys Arg 
        35                  40                  45  


<210>  161
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  161

Pro Cys His Leu Leu Pro Asn Cys Thr Ser Cys Leu Asp Ser Lys Gly 
1               5                   10                  15      


Ala Asp Gly Gly Trp Gln His Cys Val Trp Ser Ser Ser Leu Gln Gln 
            20                  25                  30          


Cys Leu Ser Pro Ser Tyr Cys Met Ala Gly Gly Cys Gly Arg Leu Leu 
        35                  40                  45              


Arg Gly Pro Glu Ser Cys Ser 
    50                  55  


<210>  162
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  162

Pro Cys Arg Leu Leu Ser Ser Pro Glu Ala Cys Asn Gln Ser Gly Ala 
1               5                   10                  15      


Cys Thr Trp Cys His Gly Ala Cys Leu Ser Gly Asp Gln Ala His Arg 
            20                  25                  30          


Leu Gly Cys Gly Gly Ser Pro Cys Ser 
        35                  40      


<210>  163
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  163

Asp Cys Val Ala Val Thr Ala Gln Cys Gln Ala Cys Val Ser Ser Arg 
1               5                   10                  15      


Trp Gly Cys Asn Trp Cys Val Trp Gln His Leu Cys Thr His Lys Ala 
            20                  25                  30          


Ser Cys Asp Ala Gly Pro Met Val Ala Ser His Gln Ser Pro 
        35                  40                  45      


<210>  164
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  164

Asn Cys Ala Met Gly Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu 
1               5                   10                  15      


Asp Leu Gly His Leu Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly 
            20                  25                  30          


Pro Leu Gln Pro Met Ala Gly Thr Cys Pro 
        35                  40          


<210>  165
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  165

Asp Cys Arg Gln Ala Met Leu Pro Cys Ile Ser Cys Val Ser Asn Arg 
1               5                   10                  15      


Trp Thr Cys Gln Trp Asp Leu Arg Tyr His Glu Cys Arg Glu Ala Ser 
            20                  25                  30          


Pro Asn Pro Glu Asp Gly Ile Val Arg Ala His Met Glu Asp Ser Cys 
        35                  40                  45              


Pro 
    


<210>  166
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  166

Glu Cys Arg Arg Leu Arg Thr Cys Ser Glu Cys Leu Ala Arg His Pro 
1               5                   10                  15      


Arg Thr Leu Gln Pro Gly Asp Gly Glu Ala Ser Ile Pro Arg Cys Lys 
            20                  25                  30          


Trp Cys Thr Asn Cys Pro Glu Gly Ala Cys Ile Gly Arg Asn Gly Ser 
        35                  40                  45              


Cys Thr 
    50  


<210>  167
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  167

Arg Cys Lys Lys Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val 
1               5                   10                  15      


Asp Lys Asp Cys Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg 
            20                  25                  30          


Cys Asn Thr Gln Ala Glu Leu Leu Ala Ala Gly Cys Gln 
        35                  40                  45  


