                         SEQUENCE LISTING

<110>  UNIVERSITY OF SOUTHERN CALIFORNIA
       WANG, Pin
       HAN, Xiaolu
       BRYSON, Paul
 
<120>  MASKING CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TUMOR-SPECIFIC 
       ACTIVATION

<130>  065715-000066WO00

<150>  62/185,398
<151>  2015-06-26

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Cys Ile Ser Pro Arg Gly Cys Pro Asp Gly Pro Tyr Val Met Tyr 
1               5                   10                  15  


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Leu Ser Gly Arg Ser Asp Asn His 
1               5               


<210>  3
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Gln Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Cys His Tyr Ser Glu Leu 
1               5       


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Asp Val Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Asp Val Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Gln Gly Gln Ser Gly Gln Cys Ile Ser Pro Arg Gly Cys Pro Asp Gly 
1               5                   10                  15      


Pro Tyr Val Met Tyr 
            20      


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Leu Ser Gly Arg Ser Asp Asn His Gly Ser Ser Gly Thr 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10              


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Gly Ser Ser Gly Thr 
1               5   


<210>  12
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gln Gly Gln Ser Gly Gln Cys Ile Ser Pro Arg Gly Cys Pro Asp Gly 
1               5                   10                  15      


Pro Tyr Val Met Tyr Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Leu Ser Gly Arg Ser Asp Asn His Gly Ser Ser Gly Thr 
        35                  40                  45          


<210>  13
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  14
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Tyr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  15
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Leu Leu Gly Pro Tyr Glu Leu Trp Glu Leu Ser His 
1               5                   10          


<210>  18
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
tatgaattcg ccaccatggt attgctgcct gggtcc                                 36


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
gcggaattct taaaggttac cttcgttctc tagggc                                 36


<210>  20
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
tatgtcgaca tgcgaccctc cgggacggcg gaattcttaa aggttacctt cgttctctag       60

ggc                                                                     63


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
tcgtctagac cttcactgtg tctgcaaatc tgcc                                   34


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Arg Cys Asn Pro Asn Met Glu Pro Pro Arg Cys Trp Ala Ala Glu Gly 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Val Cys Asn Pro Leu Thr Gly Ala Leu Leu Cys Ser Ala Ala Glu Gly 
1               5                   10                  15      


Asp 
    


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Leu Ser Thr Ala Phe Ala Arg Val 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu 
1               5                   10      


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Val Leu Val Pro Met Ala Met Met Ala Ser 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Pro Val Gly Leu Ile Gly 
1               5       


<210>  29
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Gln Gly Gln Ser Gly Gln Cys Ile Ser Pro Arg Gly Cys Pro Asp Gly 
1               5                   10                  15      


Pro Tyr Val Met Tyr Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Leu Ser Gly Arg Ser Asp Asn His Ile Leu Leu Thr Gln Ser 
        35                  40                  45              


Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg 
65                  70                  75                  80  


Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile 
                85                  90                  95      


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            100                 105                 110         


Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr 
        115                 120                 125             


Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys 
    130                 135                 140                 


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val 
                165                 170                 175     


Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
            180                 185                 190         


Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly 
        195                 200                 205             


Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 
    210                 215                 220                 


Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser 
225                 230                 235                 240 


Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile 
                245                 250                 255     


Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Tyr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    370                 375                 380                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser 
385                 390                 395                 400 


Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                405                 410                 415     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            420                 425                 430         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
        435                 440                 445             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
465                 470                 475                 480 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                485                 490                 495     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            500                 505                 510         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        515                 520                 525             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    530                 535                 540                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 555     


