                         SEQUENCE LISTING

<110>  UNIVERSITY OF SOUTHERN CALIFORNIA
       ICHIDA, Justin
       LIN, Shaoyu
       LI, Yichen
       SHI, Yingxiao
 
<120>  METHODS TO TREAT NEUROLOGICAL DISEASES

<130>  029680-9026-WO00

<140>  PCT/US2016/039425
<141>  2016-06-24

<150>  US 62/184,732
<151>  2015-06-25

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RP-PCT primer, Forward


<220>
<221>  5'clip
<222>  (1)..(1)
<223>  6FAM

<400>  1
tgtaaaacga cggccagtca aggagggaaa caaccgcagc c                           41


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RP-PCT primer, Reverse-1


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  2
caggaaacag ctatgacc                                                     18


<210>  3
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RP-PCT primer, Reverse-2


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  3
caggaaacag ctatgaccgg gcccgccccg accacgcccc ggccccggcc ccgg             54


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating Southern probe, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  4
agaacaggac aagttgcc                                                     18


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for generating Southern probe, Reverse


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  5
aacacacacc tcctaaacc                                                    19


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Genotyping primers for C9ORF72 exon 2, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  6
cccacacctg ctcttgctag acc                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Genotyping primers for C9ORF72 exon 2, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  7
cccacacctg ctcttgctag acc                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for C9ORF72, transcriptional variants 1,3, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  8
gtaacctacg gtgtcccgct agg                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for C9ORF72, transcriptional variants 1,3, Reverse


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  9
cccacacctg ctcttgctag acc                                               23


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for C9ORF72, transcriptional variants 2, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  10
gtggcgagtg gatatctccg ga                                                22


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for C9ORF72, transcriptional variants 2, Reverse


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  11
tggagcccaa atgtgcctta ctc                                               23


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for GAPDH, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  12
cgagatccct ccaaaatcaa                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for GAPDH, Reverse


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  13
gtcttctggg tggcagtgat                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for NMDAR1, Forward


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  14
ccagcgtgtg gtttgagatg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR primer for NMDAR1, Reverse


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  15
ttctctgcct tggactcacg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-1 targeting upstream of repeat expansion


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  16
guaaccuacg gugucccgcu                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2a targeting downstream of repeat expansion (+ strand)


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  17
gggguucggc ugccgggaag                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2b targeting downstream of repeat expansion (- strand)


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  18
accccaaaca gccacccgcc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-3 targeting C9ORF72 exon 2


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  19
uuaacacaua uaauccggaa                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-4 targeting C9ORF72 exon 2


<220>
<221>  5'clip
<222>  (1)..(1)

<400>  20
caccacucuc ugcauuucga                                                   20


