                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF

<130>  D0504.70089WO00

<140>  PCT/US2016/039312
<141>  2016-06-24

<150>  US 62/185,334
<151>  2015-06-26

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  2
<211>  1490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly 
1               5                   10                  15      


Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser 
            20                  25                  30          


Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys 
        35                  40                  45              


His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly 
    50                  55                  60                  


Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser 
65                  70                  75                  80  


Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn 
                85                  90                  95      


Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg 
            100                 105                 110         


His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr 
        115                 120                 125             


Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys 
    130                 135                 140                 


Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp 
145                 150                 155                 160 


Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser 
                165                 170                 175     


Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser 
            180                 185                 190         


Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys 
        195                 200                 205             


Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His 
    210                 215                 220                 


Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala 
225                 230                 235                 240 


Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser 
                245                 250                 255     


Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg 
            260                 265                 270         


Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser 
        275                 280                 285             


Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro 
    290                 295                 300                 


Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser 
305                 310                 315                 320 


Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe 
                325                 330                 335     


Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser 
            340                 345                 350         


Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser 
        355                 360                 365             


His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile 
    370                 375                 380                 


Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp 
                405                 410                 415     


Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn 
            420                 425                 430         


Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro 
        435                 440                 445             


Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn 
    450                 455                 460                 


Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys 
465                 470                 475                 480 


Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys 
                485                 490                 495     


Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile 
            500                 505                 510         


Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro 
        515                 520                 525             


Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro 
    530                 535                 540                 


Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu 
545                 550                 555                 560 


Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val 
                565                 570                 575     


Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr 
            580                 585                 590         


Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser 
        595                 600                 605             


Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr 
    610                 615                 620                 


Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Asp Asp 
625                 630                 635                 640 


Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys 
                645                 650                 655     


Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro 
            660                 665                 670         


Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro 
        675                 680                 685             


Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile 
    690                 695                 700                 


Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly 
705                 710                 715                 720 


Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly 
                725                 730                 735     


Thr Tyr Gly Gln Val Tyr Lys Ala Lys Asp Lys Asp Thr Gly Glu Leu 
            740                 745                 750         


Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro 
        755                 760                 765             


Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg 
    770                 775                 780                 


Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu 
785                 790                 795                 800 


Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met 
                805                 810                 815     


Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser 
            820                 825                 830         


Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu 
        835                 840                 845             


Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn 
    850                 855                 860                 


Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu 
865                 870                 875                 880 


Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val 
                885                 890                 895     


Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg 
            900                 905                 910         


Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu 
        915                 920                 925             


Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln 
    930                 935                 940                 


Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp 
945                 950                 955                 960 


Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys 
                965                 970                 975     


Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala 
            980                 985                 990         


Ala Leu Asp Leu Leu Asp His Met  Leu Thr Leu Asp Pro  Ser Lys Arg 
        995                 1000                 1005             


Cys Thr  Ala Glu Gln Thr Leu  Gln Ser Asp Phe Leu  Lys Asp Val 
    1010                 1015                 1020             


Glu Leu  Ser Lys Met Ala Pro  Pro Asp Leu Pro His  Trp Gln Asp 
    1025                 1030                 1035             


Cys His  Glu Leu Trp Ser Lys  Lys Arg Arg Arg Gln  Arg Gln Ser 
    1040                 1045                 1050             


Gly Val  Val Val Glu Glu Pro  Pro Pro Ser Lys Thr  Ser Arg Lys 
    1055                 1060                 1065             


Glu Thr  Thr Ser Gly Thr Ser  Thr Glu Pro Val Lys  Asn Ser Ser 
    1070                 1075                 1080             


Pro Ala  Pro Pro Gln Pro Ala  Pro Gly Lys Val Glu  Ser Gly Ala 
    1085                 1090                 1095             


Gly Asp  Ala Ile Gly Leu Ala  Asp Ile Thr Gln Gln  Leu Asn Gln 
    1100                 1105                 1110             


Ser Glu  Leu Ala Val Leu Leu  Asn Leu Leu Gln Ser  Gln Thr Asp 
    1115                 1120                 1125             


Leu Ser  Ile Pro Gln Met Ala  Gln Leu Leu Asn Ile  His Ser Asn 
    1130                 1135                 1140             


Pro Glu  Met Gln Gln Gln Leu  Glu Ala Leu Asn Gln  Ser Ile Ser 
    1145                 1150                 1155             


Ala Leu  Thr Glu Ala Thr Ser  Gln Gln Gln Asp Ser  Glu Thr Met 
    1160                 1165                 1170             


Ala Pro  Glu Glu Ser Leu Lys  Glu Ala Pro Ser Ala  Pro Val Ile 
    1175                 1180                 1185             


Leu Pro  Ser Ala Glu Gln Thr  Thr Leu Glu Ala Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Asp  Met Gln Asn Ile Leu  Ala Val Leu Leu Ser  Gln Leu Met 
    1205                 1210                 1215             


Lys Thr  Gln Glu Pro Ala Gly  Ser Leu Glu Glu Asn  Asn Ser Asp 
    1220                 1225                 1230             


Lys Asn  Ser Gly Pro Gln Gly  Pro Arg Arg Thr Pro  Thr Met Pro 
    1235                 1240                 1245             


Gln Glu  Glu Ala Ala Ala Cys  Pro Pro His Ile Leu  Pro Pro Glu 
    1250                 1255                 1260             


Lys Arg  Pro Pro Glu Pro Pro  Gly Pro Pro Pro Pro  Pro Pro Pro 
    1265                 1270                 1275             


Pro Pro  Leu Val Glu Gly Asp  Leu Ser Ser Ala Pro  Gln Glu Leu 
    1280                 1285                 1290             


Asn Pro  Ala Val Thr Ala Ala  Leu Leu Gln Leu Leu  Ser Gln Pro 
    1295                 1300                 1305             


Glu Ala  Glu Pro Pro Gly His  Leu Pro His Glu His  Gln Ala Leu 
    1310                 1315                 1320             


Arg Pro  Met Glu Tyr Ser Thr  Arg Pro Arg Pro Asn  Arg Thr Tyr 
    1325                 1330                 1335             


Gly Asn  Thr Asp Gly Pro Glu  Thr Gly Phe Ser Ala  Ile Asp Thr 
    1340                 1345                 1350             


Asp Glu  Arg Asn Ser Gly Pro  Ala Leu Thr Glu Ser  Leu Val Gln 
    1355                 1360                 1365             


Thr Leu  Val Lys Asn Arg Thr  Phe Ser Gly Ser Leu  Ser His Leu 
    1370                 1375                 1380             


Gly Glu  Ser Ser Ser Tyr Gln  Gly Thr Gly Ser Val  Gln Phe Pro 
    1385                 1390                 1395             


Gly Asp  Gln Asp Leu Arg Phe  Ala Arg Val Pro Leu  Ala Leu His 
    1400                 1405                 1410             


Pro Val  Val Gly Gln Pro Phe  Leu Lys Ala Glu Gly  Ser Ser Asn 
    1415                 1420                 1425             


Ser Val  Val His Ala Glu Thr  Lys Leu Gln Asn Tyr  Gly Glu Leu 
    1430                 1435                 1440             


Gly Pro  Gly Thr Thr Gly Ala  Ser Ser Ser Gly Ala  Gly Leu His 
    1445                 1450                 1455             


Trp Gly  Gly Pro Thr Gln Ser  Ser Ala Tyr Gly Lys  Leu Tyr Arg 
    1460                 1465                 1470             


Gly Pro  Thr Arg Val Pro Pro  Arg Gly Gly Arg Gly  Arg Gly Val 
    1475                 1480                 1485             


Pro Tyr  
    1490 


<210>  3
<211>  1512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser 
1               5                   10                  15      


Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu 
            20                  25                  30          


Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu 
        35                  40                  45              


Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro 
    50                  55                  60                  


Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys 
65                  70                  75                  80  


Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys 
                85                  90                  95      


Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly 
            100                 105                 110         


Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln 
        115                 120                 125             


Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val 
    130                 135                 140                 


Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu 
            180                 185                 190         


Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg 
        195                 200                 205             


Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly 
    210                 215                 220                 


Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu 
225                 230                 235                 240 


Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly 
                245                 250                 255     


Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys 
            260                 265                 270         


Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu 
        275                 280                 285             


Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys 
    290                 295                 300                 


Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly 
305                 310                 315                 320 


Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg 
                325                 330                 335     


Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser 
            340                 345                 350         


Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro 
        355                 360                 365             


Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro 
    370                 375                 380                 


Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser 
385                 390                 395                 400 


Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser 
                405                 410                 415     


Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg 
            420                 425                 430         


Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser 
        435                 440                 445             


Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala 
    450                 455                 460                 


Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala 
465                 470                 475                 480 


Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr 
                485                 490                 495     


Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val 
            500                 505                 510         


Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser 
        515                 520                 525             


Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln 
    530                 535                 540                 


Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu 
                565                 570                 575     


Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly 
            580                 585                 590         


Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro 
        595                 600                 605             


Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser 
    610                 615                 620                 


Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys 
625                 630                 635                 640 


Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro 
                645                 650                 655     


Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr 
            660                 665                 670         


Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly 
        675                 680                 685             


Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys 
    690                 695                 700                 


Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr 
705                 710                 715                 720 


Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val 
                725                 730                 735     


Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu 
            740                 745                 750         


Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys 
        755                 760                 765             


Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys 
    770                 775                 780                 


Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly 
785                 790                 795                 800 


Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser 
                805                 810                 815     


Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn 
            820                 825                 830         


Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg 
        835                 840                 845             


Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser 
    850                 855                 860                 


Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg 
865                 870                 875                 880 


Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp 
                885                 890                 895     


Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro 
            900                 905                 910         


Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg 
        915                 920                 925             


Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu 
    930                 935                 940                 


Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu 
945                 950                 955                 960 


Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp 
                965                 970                 975     


Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala 
            980                 985                 990         


Leu Gln Cys Glu Phe Leu Arg Asp  Val Glu Pro Ser Lys  Met Pro Pro 
        995                 1000                 1005             


Pro Asp  Leu Pro Leu Trp Gln  Asp Cys His Glu Leu  Trp Ser Lys 
    1010                 1015                 1020             


Lys Arg  Arg Arg Gln Lys Gln  Met Gly Met Thr Asp  Asp Val Ser 
    1025                 1030                 1035             


Thr Ile  Lys Ala Pro Arg Lys  Asp Leu Ser Leu Gly  Leu Asp Asp 
    1040                 1045                 1050             


Ser Arg  Thr Asn Thr Pro Gln  Gly Val Leu Pro Ser  Ser Gln Leu 
    1055                 1060                 1065             


Lys Ser  Gln Gly Ser Ser Asn  Val Ala Pro Val Lys  Thr Gly Pro 
    1070                 1075                 1080             


Gly Gln  His Leu Asn His Ser  Glu Leu Ala Ile Leu  Leu Asn Leu 
    1085                 1090                 1095             


Leu Gln  Ser Lys Thr Ser Val  Asn Met Ala Asp Phe  Val Gln Val 
    1100                 1105                 1110             


Leu Asn  Ile Lys Val Asn Ser  Glu Thr Gln Gln Gln  Leu Asn Lys 
    1115                 1120                 1125             


Ile Asn  Leu Pro Ala Gly Ile  Leu Ala Thr Gly Glu  Lys Gln Thr 
    1130                 1135                 1140             


Asp Pro  Ser Thr Pro Gln Gln  Glu Ser Ser Lys Pro  Leu Gly Gly 
    1145                 1150                 1155             


Ile Gln  Pro Ser Ser Gln Thr  Ile Gln Pro Lys Val  Glu Thr Asp 
    1160                 1165                 1170             


Ala Ala  Gln Ala Ala Val Gln  Ser Ala Phe Ala Val  Leu Leu Thr 
    1175                 1180                 1185             


Gln Leu  Ile Lys Ala Gln Gln  Ser Lys Gln Lys Asp  Val Leu Leu 
    1190                 1195                 1200             


Glu Glu  Arg Glu Asn Gly Ser  Gly His Glu Ala Ser  Leu Gln Leu 
    1205                 1210                 1215             


Arg Pro  Pro Pro Glu Pro Ser  Thr Pro Val Ser Gly  Gln Asp Asp 
    1220                 1225                 1230             


Leu Ile  Gln His Gln Asp Met  Arg Ile Leu Glu Leu  Thr Pro Glu 
    1235                 1240                 1245             


Pro Asp  Arg Pro Arg Ile Leu  Pro Pro Asp Gln Arg  Pro Pro Glu 
    1250                 1255                 1260             


Pro Pro  Glu Pro Pro Pro Val  Thr Glu Glu Asp Leu  Asp Tyr Arg 
    1265                 1270                 1275             


Thr Glu  Asn Gln His Val Pro  Thr Thr Ser Ser Ser  Leu Thr Asp 
    1280                 1285                 1290             


Pro His  Ala Gly Val Lys Ala  Ala Leu Leu Gln Leu  Leu Ala Gln 
    1295                 1300                 1305             


His Gln  Pro Gln Asp Asp Pro  Lys Arg Glu Gly Gly  Ile Asp Tyr 
    1310                 1315                 1320             


Gln Ala  Gly Asp Thr Tyr Val  Ser Thr Ser Asp Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Phe Gly  Ser Ser Ser Phe Ser  Ser Ala Pro Tyr Val  Ser Asn Asp 
    1340                 1345                 1350             


Gly Leu  Gly Ser Ser Ser Ala  Pro Pro Leu Glu Arg  Arg Ser Phe 
    1355                 1360                 1365             


Ile Gly  Asn Ser Asp Ile Gln  Ser Leu Asp Asn Tyr  Ser Thr Ala 
    1370                 1375                 1380             


Ser Ser  His Ser Gly Gly Pro  Pro Gln Pro Ser Ala  Phe Ser Glu 
    1385                 1390                 1395             


Ser Phe  Pro Ser Ser Val Ala  Gly Tyr Gly Asp Ile  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Gly  Pro Met Leu Phe Ser  Gly Asp Lys Asp His  Arg Phe Glu 
    1415                 1420                 1425             


Tyr Ser  His Gly Pro Ile Ala  Val Leu Ala Asn Ser  Ser Asp Pro 
    1430                 1435                 1440             


Ser Thr  Gly Pro Glu Ser Thr  His Pro Leu Pro Ala  Lys Met His 
    1445                 1450                 1455             


Asn Tyr  Asn Tyr Gly Gly Asn  Leu Gln Glu Asn Pro  Ser Gly Pro 
    1460                 1465                 1470             


Ser Leu  Met His Gly Gln Thr  Trp Thr Ser Pro Ala  Gln Gly Pro 
    1475                 1480                 1485             


Gly Tyr  Ser Gln Gly Tyr Arg  Gly His Ile Ser Thr  Ser Thr Gly 
    1490                 1495                 1500             


Arg Gly  Arg Gly Arg Gly Leu  Pro Tyr 
    1505                 1510         


<210>  4
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Ala Thr Pro Gly Asn Leu Gly Ser Ser Val Leu Ala Ser Lys Thr 
1               5                   10                  15      


Lys Thr Lys Lys Lys His Phe Val Ala Gln Lys Val Lys Leu Phe Arg 
            20                  25                  30          


Ala Ser Asp Pro Leu Leu Ser Val Leu Met Trp Gly Val Asn His Ser 
        35                  40                  45              


Ile Asn Glu Leu Ser His Val Gln Ile Pro Val Met Leu Met Pro Asp 
    50                  55                  60                  


Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp Asn His Leu Phe Asn 
65                  70                  75                  80  


Lys Glu Asn Met Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Met 
                85                  90                  95      


Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile Asp Asp Gln Asp Phe 
            100                 105                 110         


Gln Asn Ser Leu Thr Arg Ser Ala Pro Leu Pro Asn Asp Ser Gln Ala 
        115                 120                 125             


Arg Ser Gly Ala Arg Phe His Thr Ser Tyr Asp Lys Arg Tyr Ile Ile 
    130                 135                 140                 


Lys Thr Ile Thr Ser Glu Asp Val Ala Glu Met His Asn Ile Leu Lys 
145                 150                 155                 160 


Lys Tyr His Gln Tyr Ile Val Glu Cys His Gly Ile Thr Leu Leu Pro 
                165                 170                 175     


Gln Phe Leu Gly Met Tyr Arg Leu Asn Val Asp Gly Val Glu Ile Tyr 
            180                 185                 190         


Val Ile Val Thr Arg Asn Val Phe Ser His Arg Leu Ser Val Tyr Arg 
        195                 200                 205             


Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg Glu Ala Ser Asp Lys 
    210                 215                 220                 


Glu Lys Ala Lys Glu Leu Pro Thr Leu Lys Asp Asn Asp Phe Ile Asn 
225                 230                 235                 240 


Glu Gly Gln Lys Ile Tyr Ile Asp Asp Asn Asn Lys Lys Val Phe Leu 
                245                 250                 255     


Glu Lys Leu Lys Lys Asp Val Glu Phe Leu Ala Gln Leu Lys Leu Met 
            260                 265                 270         


Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val Glu Arg Ala Glu Gln 
        275                 280                 285             


Glu Glu Val Glu Cys Glu Glu Asn Asp Gly Glu Glu Glu Gly Glu Ser 
    290                 295                 300                 


Asp Gly Thr His Pro Val Gly Thr Pro Pro Asp Ser Pro Gly Asn Thr 
305                 310                 315                 320 


Leu Asn Ser Ser Pro Pro Leu Ala Pro Gly Glu Phe Asp Pro Asn Ile 
                325                 330                 335     


Asp Val Tyr Gly Ile Lys Cys His Glu Asn Ser Pro Arg Lys Glu Val 
            340                 345                 350         


Tyr Phe Met Ala Ile Ile Asp Ile Leu Thr His Tyr Asp Ala Lys Lys 
        355                 360                 365             


Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu 
    370                 375                 380                 


Ile Ser Thr Val Asn Pro Glu Gln Tyr Ser Lys Arg Phe Leu Asp Phe 
385                 390                 395                 400 


Ile Gly His Ile Leu Thr 
                405     


<210>  5
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Ser Ser Asn Cys Thr Ser Thr Thr Ala Val Ala Val Ala Pro Leu 
1               5                   10                  15      


Ser Ala Ser Lys Thr Lys Thr Lys Lys Lys His Phe Val Cys Gln Lys 
            20                  25                  30          


Val Lys Leu Phe Arg Ala Ser Glu Pro Ile Leu Ser Val Leu Met Trp 
        35                  40                  45              


Gly Val Asn His Thr Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val 
    50                  55                  60                  


Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp 
65                  70                  75                  80  


Asn His Leu Phe Asn Lys Glu Asn Leu Pro Ser Arg Phe Lys Phe Lys 
                85                  90                  95      


Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile 
            100                 105                 110         


Asp Asp Gln Asp Tyr Gln Asn Ser Val Thr Arg Ser Ala Pro Ile Asn 
        115                 120                 125             


Ser Asp Ser Gln Gly Arg Cys Gly Thr Arg Phe Leu Thr Thr Tyr Asp 
    130                 135                 140                 


Arg Arg Phe Val Ile Lys Thr Val Ser Ser Glu Asp Val Ala Glu Met 
145                 150                 155                 160 


His Asn Ile Leu Lys Lys Tyr His Gln Phe Ile Val Glu Cys His Gly 
                165                 170                 175     


Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Thr Val Asp 
            180                 185                 190         


Gly Val Glu Thr Tyr Met Val Val Thr Arg Asn Val Phe Ser His Arg 
        195                 200                 205             


Leu Thr Val His Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg 
    210                 215                 220                 


Glu Ala Ser Asp Lys Glu Lys Ala Lys Asp Leu Pro Thr Phe Lys Asp 
225                 230                 235                 240 


Asn Asp Phe Leu Asn Glu Gly Gln Lys Leu His Val Gly Glu Glu Ser 
                245                 250                 255     


Lys Lys Asn Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Ala 
            260                 265                 270         


Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val 
        275                 280                 285             


Asp Arg Ala Glu Gln Glu Glu Met Glu Val Glu Glu Arg Ala Glu Asp 
    290                 295                 300                 


Glu Glu Cys Glu Asn Asp Gly Val Gly Gly Asn Leu Leu Cys Ser Tyr 
305                 310                 315                 320 


Gly Thr Pro Pro Asp Ser Pro Gly Asn Leu Leu Ser Phe Pro Arg Phe 
                325                 330                 335     


Phe Gly Pro Gly Glu Phe Asp Pro Ser Val Asp Val Tyr Ala Met Lys 
            340                 345                 350         


Ser His Glu Ser Ser Pro Lys Lys Glu Val Tyr Phe Met Ala Ile Ile 
        355                 360                 365             


Asp Ile Leu Thr Pro Tyr Asp Thr Lys Lys Lys Ala Ala His Ala Ala 
    370                 375                 380                 


Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro 
385                 390                 395                 400 


Glu Gln Tyr Ser Lys Arg Phe Asn Glu Phe Met Ser Asn Ile Leu Thr 
                405                 410                 415     


<210>  6
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
225                 230                 235                 240 


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
                245                 250                 255     


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
            260                 265                 270         


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
        275                 280                 285             


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
    290                 295                 300                 


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
305                 310                 315                 320 


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
                325                 330                 335     


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
            340                 345                 350         


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
        355                 360                 365             


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
    370                 375                 380                 


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
385                 390                 395                 400 


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
                405                 410                 415     


Thr Asn Ile Phe Ala 
            420     


<210>  7
<211>  1221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Ala Thr Gly Gly Cys Gly Ala Cys Cys Cys Cys Cys Gly Gly Cys Ala 
1               5                   10                  15      


Ala Cys Cys Thr Ala Gly Gly Gly Thr Cys Cys Thr Cys Thr Gly Thr 
            20                  25                  30          


Cys Cys Thr Gly Gly Cys Gly Ala Gly Cys Ala Ala Gly Ala Cys Cys 
        35                  40                  45              


Ala Ala Gly Ala Cys Cys Ala Ala Gly Ala Ala Gly Ala Ala Gly Cys 
    50                  55                  60                  


Ala Cys Thr Thr Cys Gly Thr Ala Gly Cys Gly Cys Ala Gly Ala Ala 
65                  70                  75                  80  


Ala Gly Thr Gly Ala Ala Gly Cys Thr Gly Thr Thr Thr Cys Gly Gly 
                85                  90                  95      


Gly Cys Cys Ala Gly Cys Gly Ala Cys Cys Cys Gly Cys Thr Gly Cys 
            100                 105                 110         


Thr Cys Ala Gly Cys Gly Thr Cys Cys Thr Cys Ala Thr Gly Thr Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Thr Ala Ala Ala Cys Cys Ala Cys Thr Cys Gly 
    130                 135                 140                 


Ala Thr Cys Ala Ala Thr Gly Ala Ala Cys Thr Gly Ala Gly Cys Cys 
145                 150                 155                 160 


Ala Thr Gly Thr Thr Cys Ala Ala Ala Thr Cys Cys Cys Thr Gly Thr 
                165                 170                 175     


Thr Ala Thr Gly Thr Thr Gly Ala Thr Gly Cys Cys Ala Gly Ala Thr 
            180                 185                 190         


Gly Ala Cys Thr Thr Cys Ala Ala Ala Gly Cys Cys Thr Ala Thr Thr 
        195                 200                 205             


Cys Ala Ala Ala Ala Ala Thr Ala Ala Ala Gly Gly Thr Gly Gly Ala 
    210                 215                 220                 


Cys Ala Ala Thr Cys Ala Cys Cys Thr Thr Thr Thr Thr Ala Ala Cys 
225                 230                 235                 240 


Ala Ala Ala Gly Ala Ala Ala Ala Cys Ala Thr Gly Cys Cys Gly Ala 
                245                 250                 255     


Gly Cys Cys Ala Thr Thr Thr Cys Ala Ala Gly Thr Thr Thr Ala Ala 
            260                 265                 270         


Gly Gly Ala Ala Thr Ala Cys Thr Gly Cys Cys Cys Gly Ala Thr Gly 
        275                 280                 285             


Gly Thr Cys Thr Thr Cys Cys Gly Thr Ala Ala Cys Cys Thr Gly Cys 
    290                 295                 300                 


Gly Gly Gly Ala Gly Ala Gly Gly Thr Thr Thr Gly Gly Ala Ala Thr 
305                 310                 315                 320 


Thr Gly Ala Thr Gly Ala Thr Cys Ala Ala Gly Ala Thr Thr Thr Cys 
                325                 330                 335     


Cys Ala Gly Ala Ala Thr Thr Cys Cys Cys Thr Gly Ala Cys Cys Ala 
            340                 345                 350         


Gly Gly Ala Gly Cys Gly Cys Ala Cys Cys Cys Cys Thr Cys Cys Cys 
        355                 360                 365             


Cys Ala Ala Cys Gly Ala Cys Thr Cys Cys Cys Ala Gly Gly Cys Cys 
    370                 375                 380                 


Cys Gly Cys Ala Gly Thr Gly Gly Ala Gly Cys Thr Cys Gly Thr Thr 
385                 390                 395                 400 


Thr Thr Cys Ala Cys Ala Cys Thr Thr Cys Cys Thr Ala Cys Gly Ala 
                405                 410                 415     


Cys Ala Ala Ala Ala Gly Ala Thr Ala Cys Ala Thr Cys Ala Thr Cys 
            420                 425                 430         


Ala Ala Gly Ala Cys Thr Ala Thr Thr Ala Cys Cys Ala Gly Thr Gly 
        435                 440                 445             


Ala Ala Gly Ala Cys Gly Thr Gly Gly Cys Cys Gly Ala Ala Ala Thr 
    450                 455                 460                 


Gly Cys Ala Cys Ala Ala Cys Ala Thr Cys Cys Thr Gly Ala Ala Gly 
465                 470                 475                 480 


Ala Ala Ala Thr Ala Cys Cys Ala Cys Cys Ala Gly Thr Ala Cys Ala 
                485                 490                 495     


Thr Ala Gly Thr Gly Gly Ala Ala Thr Gly Thr Cys Ala Thr Gly Gly 
            500                 505                 510         


Gly Ala Thr Cys Ala Cys Cys Cys Thr Thr Cys Thr Thr Cys Cys Cys 
        515                 520                 525             


Cys Ala Gly Thr Thr Cys Thr Thr Gly Gly Gly Cys Ala Thr Gly Thr 
    530                 535                 540                 


Ala Cys Cys Gly Gly Cys Thr Thr Ala Ala Thr Gly Thr Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Gly Ala Gly Thr Thr Gly Ala Ala Ala Thr Ala Thr Ala Thr 
                565                 570                 575     


Gly Thr Gly Ala Thr Ala Gly Thr Thr Ala Cys Ala Ala Gly Ala Ala 
            580                 585                 590         


Ala Thr Gly Thr Ala Thr Thr Cys Ala Gly Cys Cys Ala Cys Cys Gly 
        595                 600                 605             


Thr Thr Thr Gly Thr Cys Thr Gly Thr Gly Thr Ala Thr Ala Gly Gly 
    610                 615                 620                 


Ala Ala Ala Thr Ala Cys Gly Ala Cys Thr Thr Ala Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Cys Thr Cys Thr Ala Cys Ala Gly Thr Gly Gly Cys Thr Ala Gly 
                645                 650                 655     


Ala Gly Ala Ala Gly Cys Thr Ala Gly Thr Gly Ala Cys Ala Ala Ala 
            660                 665                 670         


Gly Ala Ala Ala Ala Gly Gly Cys Cys Ala Ala Ala Gly Ala Ala Cys 
        675                 680                 685             


Thr Gly Cys Cys Ala Ala Cys Thr Cys Thr Gly Ala Ala Ala Gly Ala 
    690                 695                 700                 


Thr Ala Ala Thr Gly Ala Thr Thr Thr Cys Ala Thr Thr Ala Ala Thr 
705                 710                 715                 720 


Gly Ala Gly Gly Gly Cys Cys Ala Ala Ala Ala Gly Ala Thr Thr Thr 
                725                 730                 735     


Ala Thr Ala Thr Thr Gly Ala Thr Gly Ala Cys Ala Ala Cys Ala Ala 
            740                 745                 750         


Cys Ala Ala Gly Ala Ala Gly Gly Thr Cys Thr Thr Cys Cys Thr Gly 
        755                 760                 765             


Gly Ala Ala Ala Ala Ala Cys Thr Ala Ala Ala Ala Ala Ala Gly Gly 
    770                 775                 780                 


Ala Thr Gly Thr Thr Gly Ala Gly Thr Thr Thr Cys Thr Gly Gly Cys 
785                 790                 795                 800 


Cys Cys Ala Gly Cys Thr Gly Ala Ala Gly Cys Thr Cys Ala Thr Gly 
                805                 810                 815     


Gly Ala Cys Thr Ala Cys Ala Gly Thr Cys Thr Gly Cys Thr Gly Gly 
            820                 825                 830         


Thr Gly Gly Gly Ala Ala Thr Thr Cys Ala Thr Gly Ala Thr Gly Thr 
        835                 840                 845             


Gly Gly Ala Gly Ala Gly Ala Gly Cys Cys Gly Ala Ala Cys Ala Gly 
    850                 855                 860                 


Gly Ala Gly Gly Ala Ala Gly Thr Gly Gly Ala Gly Thr Gly Thr Gly 
865                 870                 875                 880 


Ala Gly Gly Ala Gly Ala Ala Cys Gly Ala Thr Gly Gly Gly Gly Ala 
                885                 890                 895     


Gly Gly Ala Gly Gly Ala Gly Gly Gly Cys Gly Ala Gly Ala Gly Cys 
            900                 905                 910         


Gly Ala Thr Gly Gly Cys Ala Cys Cys Cys Ala Cys Cys Cys Gly Gly 
        915                 920                 925             


Thr Gly Gly Gly Ala Ala Cys Cys Cys Cys Cys Cys Cys Ala Gly Ala 
    930                 935                 940                 


Thr Ala Gly Cys Cys Cys Cys Gly Gly Gly Ala Ala Thr Ala Cys Ala 
945                 950                 955                 960 


Cys Thr Gly Ala Ala Cys Ala Gly Cys Thr Cys Ala Cys Cys Ala Cys 
                965                 970                 975     


Cys Cys Cys Thr Gly Gly Cys Thr Cys Cys Cys Gly Gly Gly Gly Ala 
            980                 985                 990         


Gly Thr Thr Cys Gly Ala Thr Cys  Cys Gly Ala Ala Cys  Ala Thr Cys 
        995                 1000                 1005             


Gly Ala  Cys Gly Thr Cys Thr  Ala Thr Gly Gly Ala  Ala Thr Thr 
    1010                 1015                 1020             


Ala Ala  Gly Thr Gly Cys Cys  Ala Thr Gly Ala Ala  Ala Ala Cys 
    1025                 1030                 1035             


Thr Cys  Gly Cys Cys Thr Ala  Gly Gly Ala Ala Gly  Gly Ala Gly 
    1040                 1045                 1050             


Gly Thr  Gly Thr Ala Cys Thr  Thr Cys Ala Thr Gly  Gly Cys Ala 
    1055                 1060                 1065             


Ala Thr  Thr Ala Thr Thr Gly  Ala Cys Ala Thr Cys  Cys Thr Thr 
    1070                 1075                 1080             


Ala Cys  Thr Cys Ala Thr Thr  Ala Thr Gly Ala Thr  Gly Cys Ala 
    1085                 1090                 1095             


Ala Ala  Ala Ala Ala Gly Ala  Ala Ala Gly Cys Thr  Gly Cys Cys 
    1100                 1105                 1110             


Cys Ala  Thr Gly Cys Thr Gly  Cys Ala Ala Ala Ala  Ala Cys Thr 
    1115                 1120                 1125             


Gly Thr  Thr Ala Ala Ala Cys  Ala Thr Gly Gly Cys  Gly Cys Thr 
    1130                 1135                 1140             


Gly Gly  Cys Gly Cys Gly Gly  Ala Gly Ala Thr Cys  Thr Cys Cys 
    1145                 1150                 1155             


Ala Cys  Cys Gly Thr Gly Ala  Ala Cys Cys Cys Ala  Gly Ala Ala 
    1160                 1165                 1170             


Cys Ala  Gly Thr Ala Thr Thr  Cys Ala Ala Ala Gly  Cys Gly Cys 
    1175                 1180                 1185             


Thr Thr  Thr Thr Thr Gly Gly  Ala Cys Thr Thr Thr  Ala Thr Thr 
    1190                 1195                 1200             


Gly Gly  Cys Cys Ala Cys Ala  Thr Cys Thr Thr Gly  Ala Cys Gly 
    1205                 1210                 1215             


Thr Ala  Ala 
    1220     


<210>  8
<211>  1251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Ala Thr Gly Thr Cys Gly Thr Cys Cys Ala Ala Cys Thr Gly Cys Ala 
1               5                   10                  15      


Cys Cys Ala Gly Cys Ala Cys Cys Ala Cys Gly Gly Cys Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Cys Cys Gly Cys Thr Cys 
        35                  40                  45              


Ala Gly Cys Gly Cys Cys Ala Gly Cys Ala Ala Gly Ala Cys Cys Ala 
    50                  55                  60                  


Ala Gly Ala Cys Cys Ala Ala Gly Ala Ala Gly Ala Ala Gly Cys Ala 
65                  70                  75                  80  


Thr Thr Thr Cys Gly Thr Gly Thr Gly Cys Cys Ala Gly Ala Ala Ala 
                85                  90                  95      


Gly Thr Gly Ala Ala Gly Cys Thr Ala Thr Thr Cys Cys Gly Gly Gly 
            100                 105                 110         


Cys Cys Ala Gly Cys Gly Ala Gly Cys Cys Gly Ala Thr Cys Cys Thr 
        115                 120                 125             


Cys Ala Gly Cys Gly Thr Cys Cys Thr Gly Ala Thr Gly Thr Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Thr Gly Ala Ala Cys Cys Ala Cys Ala Cys Gly Ala 
145                 150                 155                 160 


Thr Cys Ala Ala Thr Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Ala 
                165                 170                 175     


Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Thr Gly Thr Cys 
            180                 185                 190         


Ala Thr Gly Cys Thr Ala Ala Thr Gly Cys Cys Ala Gly Ala Thr Gly 
        195                 200                 205             


Ala Cys Thr Thr Cys Ala Ala Ala Gly Cys Cys Thr Ala Cys Ala Gly 
    210                 215                 220                 


Cys Ala Ala Gly Ala Thr Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys 
225                 230                 235                 240 


Ala Ala Thr Cys Ala Thr Cys Thr Cys Thr Thr Cys Ala Ala Thr Ala 
                245                 250                 255     


Ala Gly Gly Ala Gly Ala Ala Cys Cys Thr Gly Cys Cys Cys Ala Gly 
            260                 265                 270         


Cys Cys Gly Cys Thr Thr Thr Ala Ala Gly Thr Thr Thr Ala Ala Gly 
        275                 280                 285             


Gly Ala Gly Thr Ala Thr Thr Gly Cys Cys Cys Cys Ala Thr Gly Gly 
    290                 295                 300                 


Thr Gly Thr Thr Cys Cys Gly Ala Ala Ala Cys Cys Thr Thr Cys Gly 
305                 310                 315                 320 


Gly Gly Ala Gly Ala Gly Gly Thr Thr Thr Gly Gly Ala Ala Thr Thr 
                325                 330                 335     


Gly Ala Thr Gly Ala Thr Cys Ala Gly Gly Ala Thr Thr Ala Cys Cys 
            340                 345                 350         


Ala Gly Ala Ala Thr Thr Cys Ala Gly Thr Gly Ala Cys Gly Cys Gly 
        355                 360                 365             


Cys Ala Gly Cys Gly Cys Cys Cys Cys Cys Ala Thr Cys Ala Ala Cys 
    370                 375                 380                 


Ala Gly Thr Gly Ala Cys Ala Gly Cys Cys Ala Gly Gly Gly Thr Cys 
385                 390                 395                 400 


Gly Gly Thr Gly Thr Gly Gly Cys Ala Cys Gly Cys Gly Thr Thr Thr 
                405                 410                 415     


Cys Cys Thr Cys Ala Cys Cys Ala Cys Cys Thr Ala Cys Gly Ala Cys 
            420                 425                 430         


Cys Gly Gly Cys Gly Cys Thr Thr Thr Gly Thr Cys Ala Thr Cys Ala 
        435                 440                 445             


Ala Gly Ala Cys Thr Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Ala 
    450                 455                 460                 


Gly Gly Ala Cys Gly Thr Gly Gly Cys Gly Gly Ala Gly Ala Thr Gly 
465                 470                 475                 480 


Cys Ala Cys Ala Ala Cys Ala Thr Cys Thr Thr Ala Ala Ala Gly Ala 
                485                 490                 495     


Ala Ala Thr Ala Cys Cys Ala Cys Cys Ala Gly Thr Thr Thr Ala Thr 
            500                 505                 510         


Ala Gly Thr Gly Gly Ala Gly Thr Gly Thr Cys Ala Thr Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Ala Cys Gly Cys Thr Thr Thr Thr Gly Cys Cys Ala Cys 
    530                 535                 540                 


Ala Gly Thr Thr Cys Cys Thr Gly Gly Gly Cys Ala Thr Gly Thr Ala 
545                 550                 555                 560 


Cys Cys Gly Cys Cys Thr Gly Ala Cys Cys Gly Thr Gly Gly Ala Thr 
                565                 570                 575     


Gly Gly Thr Gly Thr Gly Gly Ala Ala Ala Cys Cys Thr Ala Cys Ala 
            580                 585                 590         


Thr Gly Gly Thr Gly Gly Thr Thr Ala Cys Cys Ala Gly Gly Ala Ala 
        595                 600                 605             


Cys Gly Thr Gly Thr Thr Cys Ala Gly Cys Cys Ala Thr Cys Gly Gly 
    610                 615                 620                 


Cys Thr Cys Ala Cys Thr Gly Thr Gly Cys Ala Thr Cys Gly Cys Ala 
625                 630                 635                 640 


Ala Gly Thr Ala Thr Gly Ala Cys Cys Thr Cys Ala Ala Gly Gly Gly 
                645                 650                 655     


Thr Thr Cys Thr Ala Cys Gly Gly Thr Thr Gly Cys Cys Ala Gly Ala 
            660                 665                 670         


Gly Ala Ala Gly Cys Gly Ala Gly Cys Gly Ala Cys Ala Ala Gly Gly 
        675                 680                 685             


Ala Gly Ala Ala Gly Gly Cys Cys Ala Ala Gly Gly Ala Cys Thr Thr 
    690                 695                 700                 


Gly Cys Cys Ala Ala Cys Ala Thr Thr Cys Ala Ala Ala Gly Ala Cys 
705                 710                 715                 720 


Ala Ala Thr Gly Ala Cys Thr Thr Cys Cys Thr Cys Ala Ala Thr Gly 
                725                 730                 735     


Ala Ala Gly Gly Gly Cys Ala Gly Ala Ala Gly Cys Thr Gly Cys Ala 
            740                 745                 750         


Thr Gly Thr Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Thr 
        755                 760                 765             


Ala Ala Ala Ala Ala Gly Ala Ala Cys Thr Thr Cys Cys Thr Gly Gly 
    770                 775                 780                 


Ala Gly Ala Ala Ala Cys Thr Gly Ala Ala Gly Cys Gly Gly Gly Ala 
785                 790                 795                 800 


Cys Gly Thr Thr Gly Ala Gly Thr Thr Cys Thr Thr Gly Gly Cys Ala 
                805                 810                 815     


Cys Ala Gly Cys Thr Gly Ala Ala Gly Ala Thr Cys Ala Thr Gly Gly 
            820                 825                 830         


Ala Cys Thr Ala Cys Ala Gly Cys Cys Thr Gly Cys Thr Gly Gly Thr 
        835                 840                 845             


Gly Gly Gly Cys Ala Thr Cys Cys Ala Cys Gly Ala Cys Gly Thr Gly 
    850                 855                 860                 


Gly Ala Cys Cys Gly Gly Gly Cys Ala Gly Ala Gly Cys Ala Gly Gly 
865                 870                 875                 880 


Ala Gly Gly Ala Gly Ala Thr Gly Gly Ala Gly Gly Thr Gly Gly Ala 
                885                 890                 895     


Gly Gly Ala Gly Cys Gly Gly Gly Cys Ala Gly Ala Gly Gly Ala Cys 
            900                 905                 910         


Gly Ala Gly Gly Ala Gly Thr Gly Thr Gly Ala Gly Ala Ala Thr Gly 
        915                 920                 925             


Ala Thr Gly Gly Gly Gly Thr Gly Gly Gly Thr Gly Gly Cys Ala Ala 
    930                 935                 940                 


Cys Cys Thr Ala Cys Thr Cys Thr Gly Cys Thr Cys Cys Thr Ala Thr 
945                 950                 955                 960 


Gly Gly Cys Ala Cys Ala Cys Cys Thr Cys Cys Gly Gly Ala Cys Ala 
                965                 970                 975     


Gly Cys Cys Cys Thr Gly Gly Cys Ala Ala Cys Cys Thr Cys Cys Thr 
            980                 985                 990         


Cys Ala Gly Cys Thr Thr Thr Cys  Cys Thr Cys Gly Gly  Thr Thr Cys 
        995                 1000                 1005             


Thr Thr  Thr Gly Gly Thr Cys  Cys Thr Gly Gly Gly  Gly Ala Ala 
    1010                 1015                 1020             


Thr Thr  Cys Gly Ala Cys Cys  Cys Cys Thr Cys Thr  Gly Thr Thr 
    1025                 1030                 1035             


Gly Ala  Cys Gly Thr Cys Thr  Ala Thr Gly Cys Cys  Ala Thr Gly 
    1040                 1045                 1050             


Ala Ala  Ala Ala Gly Cys Cys  Ala Thr Gly Ala Ala  Ala Gly Thr 
    1055                 1060                 1065             


Thr Cys  Cys Cys Cys Cys Ala  Ala Gly Ala Ala Gly  Gly Ala Gly 
    1070                 1075                 1080             


Gly Thr  Gly Thr Ala Thr Thr  Thr Cys Ala Thr Gly  Gly Cys Cys 
    1085                 1090                 1095             


Ala Thr  Cys Ala Thr Thr Gly  Ala Thr Ala Thr Cys  Cys Thr Cys 
    1100                 1105                 1110             


Ala Cys  Gly Cys Cys Ala Thr  Ala Cys Gly Ala Thr  Ala Cys Ala 
    1115                 1120                 1125             


Ala Ala  Gly Ala Ala Gly Ala  Ala Ala Gly Cys Thr  Gly Cys Ala 
    1130                 1135                 1140             


Cys Ala  Thr Gly Cys Thr Gly  Cys Cys Ala Ala Ala  Ala Cys Gly 
    1145                 1150                 1155             


Gly Thr  Gly Ala Ala Ala Cys  Ala Cys Gly Gly Gly  Gly Cys Ala 
    1160                 1165                 1170             


Gly Gly  Gly Gly Cys Cys Gly  Ala Gly Ala Thr Cys  Thr Cys Gly 
    1175                 1180                 1185             


Ala Cys  Thr Gly Thr Gly Ala  Ala Cys Cys Cys Thr  Gly Ala Gly 
    1190                 1195                 1200             


Cys Ala  Gly Thr Ala Cys Thr  Cys Cys Ala Ala Ala  Cys Gly Cys 
    1205                 1210                 1215             


Thr Thr  Cys Ala Ala Cys Gly  Ala Gly Thr Thr Thr  Ala Thr Gly 
    1220                 1225                 1230             


Thr Cys  Cys Ala Ala Cys Ala  Thr Cys Cys Thr Gly  Ala Cys Gly 
    1235                 1240                 1245             


Thr Ala  Gly 
    1250     


<210>  9
<211>  1266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Ala Thr Gly Gly Cys Gly Thr Cys Cys Thr Cys Cys Thr Cys Gly Gly 
1               5                   10                  15      


Thr Cys Cys Cys Ala Cys Cys Ala Gly Cys Cys Ala Cys Gly Gly Thr 
            20                  25                  30          


Ala Thr Cys Gly Gly Cys Gly Gly Cys Gly Ala Cys Ala Gly Cys Ala 
        35                  40                  45              


Gly Gly Cys Cys Cys Cys Gly Gly Cys Cys Cys Ala Gly Gly Thr Thr 
    50                  55                  60                  


Thr Cys Gly Gly Cys Thr Thr Cys Gly Cys Cys Thr Cys Cys Ala Ala 
65                  70                  75                  80  


Gly Ala Cys Cys Ala Ala Gly Ala Ala Gly Ala Ala Gly Cys Ala Thr 
                85                  90                  95      


Thr Thr Cys Gly Thr Gly Cys Ala Gly Cys Ala Gly Ala Ala Gly Gly 
            100                 105                 110         


Thr Gly Ala Ala Gly Gly Thr Gly Thr Thr Cys Cys Gly Gly Gly Cys 
        115                 120                 125             


Gly Gly Cys Cys Gly Ala Cys Cys Cys Gly Cys Thr Gly Gly Thr Gly 
    130                 135                 140                 


Gly Gly Thr Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Gly Gly Gly 
145                 150                 155                 160 


Gly Cys Gly Thr Ala Gly Cys Cys Cys Ala Cys Thr Cys Gly Ala Thr 
                165                 170                 175     


Cys Ala Ala Thr Gly Ala Gly Cys Thr Cys Ala Gly Cys Cys Ala Gly 
            180                 185                 190         


Gly Thr Gly Cys Cys Thr Cys Cys Cys Cys Cys Gly Gly Thr Gly Ala 
        195                 200                 205             


Thr Gly Cys Thr Gly Cys Thr Gly Cys Cys Ala Gly Ala Thr Gly Ala 
    210                 215                 220                 


Cys Thr Thr Thr Ala Ala Gly Gly Cys Cys Ala Gly Cys Thr Cys Cys 
225                 230                 235                 240 


Ala Ala Gly Ala Thr Cys Ala Ala Gly Gly Thr Cys Ala Ala Cys Ala 
                245                 250                 255     


Ala Thr Cys Ala Cys Cys Thr Thr Thr Thr Cys Cys Ala Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Ala Ala Ala Thr Cys Thr Gly Cys Cys Cys Ala Gly Thr 
        275                 280                 285             


Cys Ala Thr Thr Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Gly Gly 
    290                 295                 300                 


Ala Gly Thr Ala Thr Thr Gly Thr Cys Cys Cys Cys Ala Gly Gly Thr 
305                 310                 315                 320 


Cys Thr Thr Cys Ala Gly Gly Ala Ala Cys Cys Thr Cys Cys Gly Thr 
                325                 330                 335     


Gly Ala Thr Cys Gly Ala Thr Thr Thr Gly Gly Cys Ala Thr Thr Gly 
            340                 345                 350         


Ala Thr Gly Ala Cys Cys Ala Ala Gly Ala Thr Thr Ala Cys Thr Thr 
        355                 360                 365             


Gly Gly Thr Gly Thr Cys Cys Cys Thr Thr Ala Cys Cys Cys Gly Ala 
    370                 375                 380                 


Ala Ala Cys Cys Cys Cys Cys Cys Cys Ala Gly Cys Gly Ala Ala Ala 
385                 390                 395                 400 


Gly Thr Gly Ala Ala Gly Gly Cys Ala Gly Thr Gly Ala Thr Gly Gly 
                405                 410                 415     


Thr Cys Gly Cys Thr Thr Cys Cys Thr Thr Ala Thr Cys Thr Cys Cys 
            420                 425                 430         


Thr Ala Cys Gly Ala Thr Cys Gly Gly Ala Cys Thr Cys Thr Gly Gly 
        435                 440                 445             


Thr Cys Ala Thr Cys Ala Ala Ala Gly Ala Ala Gly Thr Ala Thr Cys 
    450                 455                 460                 


Cys Ala Gly Thr Gly Ala Gly Gly Ala Cys Ala Thr Thr Gly Cys Thr 
465                 470                 475                 480 


Gly Ala Cys Ala Thr Gly Cys Ala Thr Ala Gly Cys Ala Ala Cys Cys 
                485                 490                 495     


Thr Cys Thr Cys Cys Ala Ala Cys Thr Ala Thr Cys Ala Cys Cys Ala 
            500                 505                 510         


Gly Thr Ala Cys Ala Thr Thr Gly Thr Gly Ala Ala Gly Thr Gly Cys 
        515                 520                 525             


Cys Ala Thr Gly Gly Cys Ala Ala Cys Ala Cys Gly Cys Thr Thr Cys 
    530                 535                 540                 


Thr Gly Cys Cys Cys Cys Ala Gly Thr Thr Cys Cys Thr Gly Gly Gly 
545                 550                 555                 560 


Gly Ala Thr Gly Thr Ala Cys Cys Gly Ala Gly Thr Cys Ala Gly Thr 
                565                 570                 575     


Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Ala Ala Gly Ala Cys Ala 
            580                 585                 590         


Gly Cys Thr Ala Cys Ala Thr Gly Cys Thr Thr Gly Thr Gly Ala Thr 
        595                 600                 605             


Gly Cys Gly Cys Ala Ala Thr Ala Thr Gly Thr Thr Thr Ala Gly Cys 
    610                 615                 620                 


Cys Ala Cys Cys Gly Thr Cys Thr Thr Cys Cys Thr Gly Thr Gly Cys 
625                 630                 635                 640 


Ala Cys Ala Gly Gly Ala Ala Gly Thr Ala Thr Gly Ala Cys Cys Thr 
                645                 650                 655     


Cys Ala Ala Gly Gly Gly Thr Thr Cys Cys Cys Thr Ala Gly Thr Gly 
            660                 665                 670         


Thr Cys Cys Cys Gly Gly Gly Ala Ala Gly Cys Cys Ala Gly Cys Gly 
        675                 680                 685             


Ala Thr Ala Ala Gly Gly Ala Ala Ala Ala Gly Gly Thr Thr Ala Ala 
    690                 695                 700                 


Ala Gly Ala Ala Thr Thr Gly Cys Cys Cys Ala Cys Cys Cys Thr Thr 
705                 710                 715                 720 


Ala Ala Gly Gly Ala Thr Ala Thr Gly Gly Ala Cys Thr Thr Thr Cys 
                725                 730                 735     


Thr Cys Ala Ala Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly Ala Ala 
            740                 745                 750         


Ala Gly Thr Ala Thr Ala Thr Ala Thr Thr Gly Gly Thr Gly Ala Ala 
        755                 760                 765             


Gly Ala Gly Gly Ala Gly Ala Ala Gly Ala Ala Ala Ala Thr Ala Thr 
    770                 775                 780                 


Thr Thr Cys Thr Gly Gly Ala Gly Ala Ala Gly Cys Thr Gly Ala Ala 
785                 790                 795                 800 


Gly Ala Gly Ala Gly Ala Thr Gly Thr Gly Gly Ala Gly Thr Thr Thr 
                805                 810                 815     


Cys Thr Ala Gly Thr Gly Cys Ala Gly Cys Thr Gly Ala Ala Gly Ala 
            820                 825                 830         


Thr Cys Ala Thr Gly Gly Ala Cys Thr Ala Cys Ala Gly Cys Cys Thr 
        835                 840                 845             


Thr Cys Thr Gly Cys Thr Ala Gly Gly Cys Ala Thr Cys Cys Ala Cys 
    850                 855                 860                 


Gly Ala Cys Ala Thr Cys Ala Thr Thr Cys Gly Gly Gly Gly Cys Thr 
865                 870                 875                 880 


Cys Thr Gly Ala Ala Cys Cys Ala Gly Ala Gly Gly Ala Gly Gly Ala 
                885                 890                 895     


Ala Gly Cys Gly Cys Cys Cys Gly Thr Gly Cys Gly Gly Gly Ala Gly 
            900                 905                 910         


Gly Ala Thr Gly Ala Gly Thr Cys Ala Gly Ala Gly Gly Thr Gly Gly 
        915                 920                 925             


Ala Thr Gly Gly Gly Gly Ala Cys Thr Gly Cys Ala Gly Cys Cys Thr 
    930                 935                 940                 


Gly Ala Cys Thr Gly Gly Ala Cys Cys Thr Cys Cys Thr Gly Cys Thr 
945                 950                 955                 960 


Cys Thr Gly Gly Thr Gly Gly Gly Cys Thr Cys Cys Thr Ala Thr Gly 
                965                 970                 975     


Gly Cys Ala Cys Cys Thr Cys Cys Cys Cys Ala Gly Ala Gly Gly Gly 
            980                 985                 990         


Thr Ala Thr Cys Gly Gly Ala Gly  Gly Cys Thr Ala Cys  Ala Thr Cys 
        995                 1000                 1005             


Cys Ala  Thr Thr Cys Cys Cys  Ala Thr Cys Gly Gly  Cys Cys Cys 
    1010                 1015                 1020             


Cys Thr  Gly Gly Gly Cys Cys  Cys Ala Gly Gly Ala  Gly Ala Gly 
    1025                 1030                 1035             


Thr Thr  Thr Gly Ala Gly Thr  Cys Cys Thr Thr Cys  Ala Thr Thr 
    1040                 1045                 1050             


Gly Ala  Thr Gly Thr Cys Thr  Ala Thr Gly Cys Cys  Ala Thr Cys 
    1055                 1060                 1065             


Cys Gly  Gly Ala Gly Thr Gly  Cys Thr Gly Ala Ala  Gly Gly Ala 
    1070                 1075                 1080             


Gly Cys  Cys Cys Cys Cys Cys  Ala Gly Ala Ala Gly  Gly Ala Gly 
    1085                 1090                 1095             


Gly Thr  Cys Thr Ala Cys Thr  Thr Cys Ala Thr Gly  Gly Gly Cys 
    1100                 1105                 1110             


Cys Thr  Cys Ala Thr Thr Gly  Ala Thr Ala Thr Cys  Cys Thr Thr 
    1115                 1120                 1125             


Ala Cys  Ala Cys Ala Gly Thr  Ala Thr Gly Ala Thr  Gly Cys Thr 
    1130                 1135                 1140             


Ala Ala  Gly Ala Ala Gly Ala  Ala Ala Gly Cys Ala  Gly Cys Thr 
    1145                 1150                 1155             


Cys Ala  Thr Gly Cys Ala Gly  Cys Cys Ala Ala Ala  Ala Cys Thr 
    1160                 1165                 1170             


Gly Thr  Cys Ala Ala Gly Cys  Ala Thr Gly Gly Gly  Gly Cys Thr 
    1175                 1180                 1185             


Gly Gly  Gly Gly Cys Ala Gly  Ala Gly Ala Thr Cys  Thr Cys Thr 
    1190                 1195                 1200             


Ala Cys  Thr Gly Thr Cys Cys  Ala Thr Cys Cys Gly  Gly Ala Gly 
    1205                 1210                 1215             


Cys Ala  Gly Thr Ala Thr Gly  Cys Thr Ala Ala Gly  Cys Gly Ala 
    1220                 1225                 1230             


Thr Thr  Cys Cys Thr Gly Gly  Ala Thr Thr Thr Thr  Ala Thr Thr 
    1235                 1240                 1245             


Ala Cys  Cys Ala Ala Cys Ala  Thr Cys Thr Thr Thr  Gly Cys Cys 
    1250                 1255                 1260             


Thr Ala  Ala 
    1265     


